Aliases & Classifications for Red Color Blindness

MalaCards integrated aliases for Red Color Blindness:

Name: Red Color Blindness 12 14
Protan Defect 12 29
Color Blindness, Red 69
Protanopia 12


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Disease Ontology 12 DOID:13910
ICD10 33 H53.54
ICD9CM 35 368.51
MeSH 42 D003117
SNOMED-CT 64 51445007
UMLS 69 C0155015

Summaries for Red Color Blindness

MalaCards based summary : Red Color Blindness, also known as protan defect, is related to colorblindness, protan and colorblindness, deutan, and has symptoms including visual disturbance An important gene associated with Red Color Blindness is OPN1LW (Opsin 1, Long Wave Sensitive), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Retinoid cycle disease events. The drugs Zinc and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and testes.

Related Diseases for Red Color Blindness

Graphical network of the top 20 diseases related to Red Color Blindness:

Diseases related to Red Color Blindness

Symptoms & Phenotypes for Red Color Blindness

UMLS symptoms related to Red Color Blindness:

visual disturbance

Drugs & Therapeutics for Red Color Blindness

Drugs for Red Color Blindness (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Zinc Approved Phase 4 7440-66-6 32051 23994
2 Analgesics Phase 4
3 Analgesics, Non-Narcotic Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Antirheumatic Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Hypoglycemic Agents Phase 4
9 insulin Phase 4
10 Insulin, Globin Zinc Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Salicylates Phase 4
13 Salicylsalicylic acid Phase 4
14 Sodium salicylate Phase 4 54-21-7
Epinephrine Approved, Vet_approved 51-43-4 5816
16 Racepinephrine Approved
Iron Approved 7439-89-6 23925
Bevacizumab Approved, Investigational 216974-75-3
Blueberry Approved, Nutraceutical
B-Carotene Approved, Nutraceutical 7235-40-7 5280489
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
Glucosamine Approved, Nutraceutical 3416-24-8 439213
24 Epinephryl borate
25 Antioxidants
26 Carotenoids
27 Micronutrients
28 Protective Agents
29 Retinol palmitate
30 Trace Elements
31 Vitamins
32 Anticoagulants
33 Antimetabolites
34 Fibrinolytic Agents
35 Glucuronyl glucosamine glycan sulfate
36 Hypolipidemic Agents
37 Lipid Regulating Agents
38 Angiogenesis Inhibitors
39 Angiogenesis Modulating Agents
40 Endothelial Growth Factors
41 Mitogens
42 Anthocyanidin Nutraceutical
43 Citrate Nutraceutical
Citric Acid Nutraceutical, Vet_approved 77-92-9 311
45 Cassava Nutraceutical
46 retinol Nutraceutical

Interventional clinical trials:

(show all 13)

id Name Status NCT ID Phase Drugs
1 The Effects of Anti-Inflammatory Treatment on Insulin Resistance in Healthy Volunteers Completed NCT00339833 Phase 4 Salsalate;Placebo
2 Premature Infants in Need of Transfusion (PINT) Completed NCT00182390 Phase 3
3 Blueberry Effects on Dark Vision and Glare Recovery Completed NCT01942746
4 Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari Completed NCT02210507
5 Long Term Follow-Up of Diabetic Retinopathy Completed NCT00001395
6 The Effects of Genetic Differences Among AIDS Patients on Cytomegalovirus Retinitis Completed NCT00341172
7 Evaluating Color Perception Under LED Red/Green and Green Dominant Light Recruiting NCT01927536
8 Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes Recruiting NCT02107976
9 Assessment of Retinal Vessel Diameters and Red Blood Velocities in Patients With BRVO and Healthy Subjects Recruiting NCT01746615
10 The Effects of Biscuits Containing Red Palm Oil on School Children With Vitamin A Deficiency in West and East Malaysia Recruiting NCT03256123
11 Rod and Cone Mediated Function in Retinal Disease Recruiting NCT02617966
12 Natural History and Genetic Studies of Usher Syndrome Active, not recruiting NCT00106743
13 Genetic Biomarkers for the Response to Anti-VEGF (Vascular Endothelial Growth Factor).Treatment in Wet Age-related Macular Degeneration (Wet ARMD) Active, not recruiting NCT02762188

Search NIH Clinical Center for Red Color Blindness

Genetic Tests for Red Color Blindness

Genetic tests related to Red Color Blindness:

id Genetic test Affiliating Genes
1 Protan Defect 29

Anatomical Context for Red Color Blindness

MalaCards organs/tissues related to Red Color Blindness:

Endothelial, Eye, Testes

Publications for Red Color Blindness

Articles related to Red Color Blindness:

id Title Authors Year
Protanopia (red color-blindness) in medaka: a simple system for producing color-blind fish and testing their spectral sensitivity. ( 28166717 )
Red color blindness. ( 100181 )

Variations for Red Color Blindness

ClinVar genetic disease variations for Red Color Blindness:

id Gene Variation Type Significance SNP ID Assembly Location
1 OPN1LW NM_020061.5(OPN1LW): c.1013G> A (p.Gly338Glu) single nucleotide variant Pathogenic rs104894913 GRCh37 Chromosome X, 153424319: 153424319

Expression for Red Color Blindness

Search GEO for disease gene expression data for Red Color Blindness.

Pathways for Red Color Blindness

GO Terms for Red Color Blindness

Cellular components related to Red Color Blindness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.55 CNGB3 OPN1LW OPN1MW RHO XG
2 photoreceptor disc membrane GO:0097381 9.13 OPN1LW OPN1MW RHO
3 photoreceptor outer segment GO:0001750 8.92 CNGB3 OPN1LW OPN1MW RHO

Biological processes related to Red Color Blindness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to stimulus GO:0050896 9.62 CNGB3 OPN1LW OPN1MW RHO
2 visual perception GO:0007601 9.46 CNGB3 OPN1LW OPN1MW RHO
3 retinoid metabolic process GO:0001523 9.43 OPN1LW OPN1MW RHO
4 positive regulation of cytokinesis GO:0032467 9.37 OPN1LW OPN1MW
5 phototransduction GO:0007602 9.13 OPN1LW OPN1MW RHO
6 protein-chromophore linkage GO:0018298 8.8 OPN1LW OPN1MW RHO

Molecular functions related to Red Color Blindness according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 photoreceptor activity GO:0009881 8.8 OPN1LW OPN1MW RHO

Sources for Red Color Blindness

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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