Reflex Sympathetic Dystrophy malady
Categories: Neuronal diseases, Rare diseases
Aliases & Descriptions for Reflex Sympathetic Dystrophy:
Orphanet epidemiological data:52
complex regional pain syndrome:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Netherlands); Age of onset: All ages; Age of death: normal life expectancy
reflex sympathetic dystrophy:
Age of onset: All ages
Global: Rare diseases
Anatomical: Neuronal diseases
ICD10: 29 28
Rare neurological diseases
NINDS:47 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.
MalaCards based summary: Reflex Sympathetic Dystrophy, also known as algodystrophy, is related to complex regional pain syndrome and algoneurodystrophy, and has symptoms including pain and chronic pain. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (Calcitonin Related Polypeptide Alpha), and among its related pathways are Endothelin and Adipocytokine signaling pathway. Affiliated tissues include skin, spinal cord and bone.
Wikipedia:69 Complex regional pain syndrome (CRPS), also known as reflex sympathetic dystrophy (RSD), is a long term... more...
Description from OMIM:50 604335
Clinical features from OMIM:604335
UMLS symptoms related to Reflex Sympathetic Dystrophy:pain, chronic pain
Drugs for Reflex Sympathetic Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):(show all 50)
Interventional clinical trials:(show top 50) (show all 101)
Search NIH Clinical Center for Reflex Sympathetic Dystrophy
MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:34
Skin, Spinal cord, Bone, Cortex, Dorsal root ganglion, Heart, Testes
Articles related to Reflex Sympathetic Dystrophy:(show top 50) (show all 509)
Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.
Cellular components related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:
Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards Suite gene sharing:
29ICD10 via Orphanet
38MESH via Orphanet
51OMIM via Orphanet
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
67UMLS via Orphanet