MCID: RFL001
MIFTS: 42

Reflex Sympathetic Dystrophy malady

Summaries for Reflex Sympathetic Dystrophy

Sources:
47OMIM, 33MalaCards
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MalaCards: Reflex Sympathetic Dystrophy is related to arthritis and osteomalacia. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Fat digestion and absorption. The compounds gnrh and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and spinal cord, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:47 604335

Aliases & Classifications for Reflex Sympathetic Dystrophy

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 47OMIM, 35MeSH
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Aliases & Descriptions:

reflex sympathetic dystrophy 8 61


External Ids:

Disease Ontology8 DOID:1811
NCIt40 C85042
OMIM47 604335
MeSH35 D012019

Related Diseases for Reflex Sympathetic Dystrophy

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Clinical Features for Reflex Sympathetic Dystrophy

Sources:
47OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Reflex Sympathetic Dystrophy

Drug clinical trials:

Search ClinicalTrials for Reflex Sympathetic Dystrophy

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Search CenterWatch for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

Anatomical Context for Reflex Sympathetic Dystrophy

Sources:
33MalaCards
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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

33
Bone marrow, Brain, Spinal cord, Kidney, Breast, Skin

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CD36, PRSS50, GABBR1, NPY, APOA1, CALCA

Publications for Reflex Sympathetic Dystrophy

Sources:
51PubMed
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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Reflex sympathetic dystrophy/complex regional pain syndrome. (18306652)
2008
2
Unusual cases of acquired leukonychia totalis and partialis secondary to reflex sympathetic dystrophy. (17958875)
2007
3
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. (17290576)
2006
4
The challenge to manage reflex sympathetic dystrophy/complex regional pain syndrome. (16139630)
2005
5
Reflex sympathetic dystrophy and causalgia. (16106603)
2004
6
Spinal-cord stimulation for reflex sympathetic dystrophy. (14980526)
2004
7
Doppler sonographic assessment of posttraumatic reflex sympathetic dystrophy. (12693623)
2003
8
Proprioceptive reflexes in patients with reflex sympathetic dystrophy. (12743675)
2003
9
Surgical sympathectomy for reflex sympathetic dystrophy syndromes. (11854724)
2002
10
Complex regional pain syndrome I (reflex sympathetic dystrophy). (11981168)
2002
11
Intra-arterial injection of Tc-99m mimicking reflex sympathetic dystrophy (RSD). (11507313)
2001
12
Complete resolution of reflex sympathetic dystrophy with thalidomide treatment. (11700165)
2001
13
Clinical aspects of multifocal or generalized tonic dystonia in reflex sympathetic dystrophy. (11425951)
2001
14
Reflex sympathetic dystrophy with hidradenitis suppurativa exacerbation: a case report. (11245766)
2001
15
Morbidity in reflex sympathetic dystrophy. (10685927)
2000
16
Vitamin C reduced the incidence of reflex sympathetic dystrophy after wrist fracture. (10859108)
2000
17
HLA-DQ1 associated with reflex sympathetic dystrophy. (10932297)
2000
18
Sudomotor abnormalities in reflex sympathetic dystrophy. (10746414)
2000
19
Reflex sympathetic dystrophy: a sympathetically mediated pain syndrome or not? (10953274)
2000
20
Adjuvant physical therapy versus occupational therapy in patients with reflex sympathetic dystrophy/complex regional pain syndrome type I. (10638876)
2000
21
Reflex sympathetic dystrophy: alternative modalities for pain management. (10829209)
2000
22
Management of reflex sympathetic dystrophy. (10445091)
1999
23
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
24
Osteopenia, bone fragility and reflex sympathetic dystrophy syndrome in a man with ureterosigmoidostomy. (9373571)
1997
25
Dual energy X-ray absorptiometry in reflex sympathetic dystrophy. (9101532)
1997
26
Spinal cord stimulation is effective in the management of reflex sympathetic dystrophy. (9055289)
1997
27
Phosphate excretion in reflex sympathetic dystrophy syndrome before and after a single infusion of pamidronate. (9090766)
1997
28
Bisphosphonates for pain relief in reflex sympathetic dystrophy? (9343496)
1997
29
Reflex sympathetic dystrophy in childhood: a case report. (9447759)
1997
30
Quantitative evaluation of sympathetic nervous system dysfunction in patients with reflex sympathetic dystrophy. (9061540)
1997
31
"Cold" reflex sympathetic dystrophy in an adult. (8697698)
1996
32
MA1nchausen's syndrome simulating reflex sympathetic dystrophy. (8782150)
1996
33
Upper limb reflex sympathetic dystrophy associated with occult malignancy. (8670004)
1996
34
Psychological characteristics of reflex sympathetic dystrophy versus myofascial pain syndromes. (8744661)
1996
35
Nerve entrapment and reflex sympathetic dystrophy after fractures of the distal radius. (7597391)
1995
36
Reflex sympathetic dystrophy. (7594306)
1995
37
The influence of local skin heating and reactive hyperaemia on skin blood flow abnormalities in patients with reflex sympathetic dystrophy (RSD). (7628522)
1995
38
Profile of Caucasian women with possible genetic predisposition to reflex sympathetic dystrophy: a pilot study. (7833579)
1994
39
Reflex sympathetic dystrophy syndrome. (8024969)
1994
40
Guanethidine for reflex sympathetic dystrophy. (8193423)
1994
41
Reflex sympathetic dystrophy in hemiplegia--two case reports and review of the literature. (7944257)
1994
42
Treatment of reflex sympathetic dystrophy with EMLA cream. (7848960)
1994
43
Reflex sympathetic dystrophy: a multimodality pain-management treatment. (8438034)
1993
44
Three-phase bone scintigraphy. Asymmetric patterns in the upper extremities of asymptomatic normals and reflex sympathetic dystrophy patients. (8242973)
1993
45
Radiological case of the month. Reflex sympathetic dystrophy. (8322753)
1993
46
Prognostic value of triple phase bone scanning for reflex sympathetic dystrophy in hemiplegia. (8328893)
1993
47
Is hyperlipidaemia a contributing factor to algodystrophy (reflex sympathetic dystrophy)? (1486745)
1992
48
Reflex sympathetic dystrophy: a disease of medical understanding. (1493348)
1992
49
Reflex sympathetic dystrophy in central cord syndrome: case report and review of the literature. (2152393)
1990
50
Reflex sympathetic dystrophy in quadriplegia: case report. (6691796)
1984

Genetic Variations for Reflex Sympathetic Dystrophy

Expression for genes affiliated with Reflex Sympathetic Dystrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reflex Sympathetic Dystrophy

Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.

Pathways for genes affiliated with Reflex Sympathetic Dystrophy

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome
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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPY, CALCA
29.4CD36, APOA1
39.4CD36, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB
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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1gnrh4510.3GABBR1
2pamidronate45 50 1112.2CD36
3calcitonin gene-related peptide4510.2NPY, CALCA
4helospectin4510.2NPY, CALCA
5guanethidine45 1111.2NPY, CALCA
6nandrolone decanoate45 1111.1CALCA, APOA1
7isoflurane45 1111.1CALCA, NPY
8tibolone4510.0CALCA, APOA1
9phosphoramidon45 1111.0CALCA, NPY
10pentylenetetrazol4510.0NPY, GABBR1
11baclofen45 1110.9NPY, GABBR1
12tiludronate45 50 1111.9CALCA, CD36
13teriparatide45 1110.9CALCA, CD36
14etidronate459.9CALCA, CD36
15silver nitrate459.9CALCA, CD36
16ibandronate45 1110.9CALCA, CD36
17calcium carbonate459.9CD36, CALCA
18muscimol45 60 2911.9GABBR1, NPY
19tartrate459.9CD36, CALCA
20vitamin k2459.9CD36, CALCA
21risedronate45 60 50 29 1113.9CD36, CALCA
22clodronate45 50 1111.9CD36, CALCA
23pyridinoline459.8CD36, CALCA
24zoledronic acid459.8CALCA, CD36
25deoxypyridinoline459.8CALCA, CD36
26alendronate45 50 1111.7CD36, CALCA
27thyroxine45 2410.7CALCA, APOA1, NPY
28glibenclamide45 29 50 6012.7APOA1, CALCA
29amphetamine45 1110.6GABBR1, NPY
305-hydroxytryptamine459.6GABBR1, NPY, CALCA
31valproate459.6APOA1, GABBR1
32indomethacin45 60 29 1112.6NPY, APOA1, CALCA
3325-hydroxyvitamin d459.5CALCA, APOA1, CD36
34captopril45 29 50 60 1113.5CD36, APOA1, CALCA
35raloxifene45 29 50 1112.5CALCA, APOA1, CD36
36norepinephrine45 11 2411.4GABBR1, NPY, CALCA
37histamine45 29 2411.4CALCA, NPY, GABBR1
38dextran sulfate459.3APOA1, CD36
39forskolin45 50 1111.2GABBR1, NPY, CALCA
40clonidine45 29 1111.2GABBR1, NPY, APOA1, CALCA
41hydroxyproline45 11 2411.2CD36, CALCA
42acetylcholine45 50 29 11 2413.2GABBR1, NPY, APOA1, CALCA
43glutamate459.1GABBR1, NPY, APOA1, CALCA
44creatinine459.1CALCA, APOA1, NPY, CD36
45estrogen458.8CD36, NPY, APOA1, CALCA

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

Sources:
16Gene Ontology
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Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.8NPY, CALCA
2endothelial cell proliferationGO:0019359.7APOA1, CALCA
3feeding behaviorGO:0076319.5NPY, CALCA
4cholesterol transportGO:0303019.4CD36, APOA1
5lipid storageGO:0199159.3APOA1, CD36

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:0080359.4CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Reflex Sympathetic Dystrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet