MCID: RFL001
MIFTS: 43

Reflex Sympathetic Dystrophy malady

Summaries for Reflex Sympathetic Dystrophy

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46OMIM, 32MalaCards
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MalaCards: Reflex Sympathetic Dystrophy is related to complex regional pain syndrome and neuropathy. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Fat digestion and absorption. The compounds gnrh and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 604335

Aliases & Classifications for Reflex Sympathetic Dystrophy

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Sources:
8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 46OMIM, 34MeSH
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Aliases & Descriptions:

reflex sympathetic dystrophy 8 60


External Ids:

Disease Ontology8 DOID:1811
NCIt39 C85042
OMIM46 604335
MeSH34 D012019

Related Diseases for Reflex Sympathetic Dystrophy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Clinical Features for Reflex Sympathetic Dystrophy

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46OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Reflex Sympathetic Dystrophy

Drug clinical trials:

Search ClinicalTrials for Reflex Sympathetic Dystrophy

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Search CenterWatch for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

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Anatomical Context for Reflex Sympathetic Dystrophy

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32MalaCards
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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

32
Bone, Skin, Spinal cord, Testes, Brain, Kidney, Bone marrow, Breast

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CD36, PRSS50, GABBR1, NPY, APOA1, CALCA

Publications for Reflex Sympathetic Dystrophy

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50PubMed
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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Unilateral Beau's lines in a case of complex regional pain syndrome (reflex sympathetic dystrophy). (23075662)
2012
2
Lawsuit verdicts and settlements involving reflex sympathetic dystrophy and complex regional pain syndrome. (22214139)
2011
3
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. (17182517)
2006
4
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
5
Magnetic resonance imaging in reflex sympathetic dystrophy syndrome of the foot. (14667563)
2003
6
Self-induced hypoxia to mimic the clinical symptoms of reflex sympathetic dystrophy. (11805486)
2002
7
Neurophysiologic aspects of patients with generalized or multifocal tonic dystonia of reflex sympathetic dystrophy. (11896357)
2002
8
Successful treatment of a nine-year case of complex regional pain syndrome type-I (reflex sympathetic dystrophy) with intravenous ketamine-infusion therapy in a warfarin-anticoagulated adult female patient. (15102163)
2002
9
Which patients with chronic reflex sympathetic dystrophy are most likely to benefit from physical therapy? (11353938)
2001
10
Intra-arterial Tc-99m MDP injection mimicking reflex sympathetic dystrophy. (11201479)
2001
11
Trans-tibial amputation for reflex sympathetic dystrophy: postoperative management. (10855442)
2000
12
Use of gabapentin in the treatment of childhood reflex sympathetic dystrophy. (10734253)
2000
13
Sympathetic innervation and function in reflex sympathetic dystrophy. (10894215)
2000
14
The Radboud skills questionnaire: construction and reliability in patients with reflex sympathetic dystrophy of one upper extremity. (10813562)
2000
15
Leg muscle reflexes mediated by cutaneous A-beta fibres are normal during gait in reflex sympathetic dystrophy. (10727919)
2000
16
Successful treatment of reflex sympathetic dystrophy by bier block with lidocaine and clonidine. (10697705)
1999
17
Cost-effectiveness analysis of adjuvant physical or occupational therapy for patients with reflex sympathetic dystrophy. (10489005)
1999
18
Reflex sympathetic dystrophy syndrome: an update. (9735732)
1998
19
Leuconychia in reflex sympathetic dystrophy: a chance association? (9767268)
1998
20
Motor dysfunction and reflex sympathetic dystrophy. Bilateral motor denervation in an experimental model. (9689764)
1998
21
Synovial effusion in reflex sympathetic dystrophy: an additional sign for diagnosis and staging. (9638836)
1998
22
Complex regional pain syndrome type I (reflex sympathetic dystrophy): more than a myth. (9674766)
1998
23
Reflex sympathetic dystrophy in children. (9655669)
1998
24
Reflex sympathetic dystrophy associated with deep peroneal nerve entrapment. (9545176)
1998
25
Experimental pressure pain in patients with complex regional pain syndrome, Type I (reflex sympathetic dystrophy). (9798828)
1998
26
The natural history of post-traumatic reflex sympathetic dystrophy. (9571473)
1998
27
Reflex Sympathetic Dystrophy in the Upper Extremity. (10795066)
1997
28
Somatic or sympathetic block for reflex sympathetic dystrophy. Which is indicated? (9279551)
1997
29
Complex regional pain syndrome (reflex sympathetic dystrophy and causalgia): management with the calcium channel blocker nifedipine and/or the alpha-sympathetic blocker phenoxybenzamine in 59 patients. (9107464)
1997
30
Phantom pain with probable reflex sympathetic dystrophy: efficacy of fentanyl infiltration of the stellate ganglion. (9168224)
1997
31
An X-ray absorptiometry study of reflex sympathetic dystrophy syndrome. (9085445)
1997
32
Dual energy X-ray absorptiometry in patients with lower limb reflex sympathetic dystrophy syndrome. (8877925)
1996
33
Reflex sympathetic dystrophy: does sympathetic dysfunction originate from peripheral neuropathy? (8619184)
1996
34
Reflex sympathetic dystrophy. (8879643)
1996
35
Reflex sympathetic dystrophy: changing concepts and taxonomy. (8577483)
1995
36
Reflex sympathetic dystrophy: evolution of microcirculatory disturbances in time. (7596630)
1995
37
Reflex sympathetic dystrophy: an adverse reaction to immunotherapy. (7897164)
1995
38
Intravenous regional sympathetic blockade for pain relief in reflex sympathetic dystrophy: a systematic review and a randomized, double-blind crossover study. (7536227)
1995
39
EMLA cream for venipuncture in patients with reflex sympathetic dystrophy. (7618753)
1995
40
Recurrent reflex sympathetic dystrophy as a manifestation of systemic lupus erythematosus. (7966092)
1994
41
Gastric irritation after ketorolac Bier block for treating reflex sympathetic dystrophy. (7880521)
1994
42
Reflex sympathetic dystrophy. A review of the literature and a long-term outcome study. (7997348)
1994
43
Reflex sympathetic dystrophy syndrome secondary to organophosphate intoxication induced neuropathy. (7535551)
1994
44
Reflex sympathetic dystrophy. (8468902)
1993
45
Acupuncture for reflex sympathetic dystrophy. (8439229)
1993
46
Epidural clonidine treatment for refractory reflex sympathetic dystrophy. (8267190)
1993
47
Increased venous alpha-adrenoceptor responsiveness in patients with reflex sympathetic dystrophy. (8383935)
1993
48
Reflex sympathetic dystrophy syndrome and osteogenesis imperfecta. A report and review of the literature. (8441151)
1993
49
Epithelioid sarcoma presenting as the reflex sympathetic dystrophy syndrome. (3671265)
1987
50
Eosinophilic fasciitis and reflex sympathetic dystrophy syndrome. (7288776)
1981

Genetic Variations for Reflex Sympathetic Dystrophy

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Expression for genes affiliated with Reflex Sympathetic Dystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reflex Sympathetic Dystrophy

Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.

Pathways for genes affiliated with Reflex Sympathetic Dystrophy

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPY, CALCA
29.4CD36, APOA1
39.4CD36, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3GABBR1
2pamidronate44 49 1112.2CD36
3calcitonin gene-related peptide4410.2NPY, CALCA
4helospectin4410.2NPY, CALCA
5guanethidine44 1111.2NPY, CALCA
6nandrolone decanoate44 1111.1CALCA, APOA1
7isoflurane44 1111.1CALCA, NPY
8tibolone4410.0CALCA, APOA1
9phosphoramidon44 1111.0CALCA, NPY
10pentylenetetrazol4410.0NPY, GABBR1
11baclofen44 1110.9NPY, GABBR1
12tiludronate44 49 1111.9CALCA, CD36
13teriparatide44 1110.9CALCA, CD36
14etidronate449.9CALCA, CD36
15silver nitrate449.9CALCA, CD36
16ibandronate44 1110.9CALCA, CD36
17calcium carbonate449.9CD36, CALCA
18muscimol44 59 2811.9GABBR1, NPY
19tartrate449.9CD36, CALCA
20vitamin k2449.9CD36, CALCA
21risedronate44 59 49 28 1113.9CD36, CALCA
22clodronate44 49 1111.9CD36, CALCA
23pyridinoline449.8CD36, CALCA
24zoledronic acid449.8CALCA, CD36
25deoxypyridinoline449.8CALCA, CD36
26alendronate44 49 1111.7CD36, CALCA
27thyroxine44 2410.7CALCA, APOA1, NPY
28glibenclamide44 28 49 5912.7APOA1, CALCA
29amphetamine44 1110.6GABBR1, NPY
305-hydroxytryptamine449.6GABBR1, NPY, CALCA
31valproate449.6APOA1, GABBR1
32indomethacin44 59 28 1112.6NPY, APOA1, CALCA
3325-hydroxyvitamin d449.5CALCA, APOA1, CD36
34captopril44 28 49 59 1113.5CD36, APOA1, CALCA
35raloxifene44 28 49 1112.5CALCA, APOA1, CD36
36norepinephrine44 11 2411.4GABBR1, NPY, CALCA
37histamine44 28 2411.4CALCA, NPY, GABBR1
38dextran sulfate449.3APOA1, CD36
39forskolin44 49 1111.2GABBR1, NPY, CALCA
40clonidine44 28 1111.2GABBR1, NPY, APOA1, CALCA
41hydroxyproline44 11 2411.2CD36, CALCA
42acetylcholine44 49 28 11 2413.2GABBR1, NPY, APOA1, CALCA
43glutamate449.1GABBR1, NPY, APOA1, CALCA
44creatinine449.1CALCA, APOA1, NPY, CD36
45estrogen448.8CD36, NPY, APOA1, CALCA

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

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16Gene Ontology
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Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.8NPY, CALCA
2endothelial cell proliferationGO:0019359.7APOA1, CALCA
3feeding behaviorGO:0076319.5NPY, CALCA
4cholesterol transportGO:0303019.4CD36, APOA1
5lipid storageGO:0199159.3APOA1, CD36

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:0080359.4CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

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  • Antibodies
  • Proteins
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Sources for Reflex Sympathetic Dystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet