MCID: RFL001
MIFTS: 48

Reflex Sympathetic Dystrophy malady

Neuronal diseases category

Summaries for Reflex Sympathetic Dystrophy

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48OMIM, 34MalaCards
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MalaCards: Reflex Sympathetic Dystrophy is related to complex regional pain syndrome and osteomalacia. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Adipocytokine signaling pathway. The compounds calcitonin gene-related peptide and tiludronate have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and spinal cord, and related mouse phenotypes are renal/urinary system and adipose tissue.

Description from OMIM:48 604335

Aliases & Classifications for Reflex Sympathetic Dystrophy

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Sources:
9Disease Ontology, 63UMLS, 28ICD9CM, 48OMIM, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

reflex sympathetic dystrophy 9 63


External Ids:

Disease Ontology9 DOID:1811
OMIM48 604335
MeSH36 D012019
NCIt41 C85042

Related Diseases for Reflex Sympathetic Dystrophy

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Sources:
18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Symptoms for Reflex Sympathetic Dystrophy

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Sources:
48OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Reflex Sympathetic Dystrophy

Drug clinical trials:

Search ClinicalTrials for Reflex Sympathetic Dystrophy

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Search CenterWatch for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

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Anatomical Context for Reflex Sympathetic Dystrophy

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Sources:
34MalaCards
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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

34
Bone, Skin, Spinal cord, Testes, Brain, Kidney, Breast

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CD36, NPY, CALCA
2MP:00053758.9GABBR1, NPY, CD36
3MP:00053868.4CALCA, GABBR1, NPY, CD36
4MP:00053708.3APOA1, NPY, CD36
5MP:00036318.3CD36, NPY, GABBR1, CALCA
6MP:00053767.6CD36, NPY, GABBR1, CALCA, APOA1

Publications for Reflex Sympathetic Dystrophy

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Sources:
53PubMed
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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
2
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. (17290576)
2006
3
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. (17182517)
2006
4
Segmental reflex sympathetic dystrophy. (16319634)
2005
5
Reflex sympathetic dystrophy and pancoast tumor. (15365437)
2004
6
Reflex sympathetic dystrophy of the foot: MRI with fat suppression is essential (letter with the drafting). (15474404)
2004
7
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
8
Reflex sympathetic dystrophy: a multidisciplinary approach. (15077274)
2004
9
Surgical sympathectomy for reflex sympathetic dystrophy syndromes. (11854724)
2002
10
Acupuncture improves peripheral perfusion in patients with reflex sympathetic dystrophy. (17039194)
2002
11
Re: The sequelae of reflex sympathetic dystrophy. (11895359)
2002
12
Reflex sympathetic dystrophy of the left hand and motor impairments of the unaffected right hand: impaired central motor processing? (11782836)
2002
13
Calcitonin in reflex sympathetic dystrophy syndrome and other painful conditions. (12008165)
2002
14
Technetium-99m sestamibi limb scintigraphy in post-traumatic reflex sympathetic dystrophy: preliminary results. (11685495)
2001
15
Thalamic perfusion in reflex sympathetic dystrophy syndrome. (10841150)
2000
16
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
17
Trans-tibial amputation for reflex sympathetic dystrophy: postoperative management. (10855442)
2000
18
Reflex sympathetic dystrophy following transbrachial cardiac catheterization. (10973376)
2000
19
Vitamin C prevents reflex sympathetic dystrophy. (10735491)
2000
20
Management of reflex sympathetic dystrophy. (10445091)
1999
21
Reflex sympathetic dystrophy in children. (10385843)
1999
22
Reflex sympathetic dystrophy in children: review of a clinical series and description of the particularities in children. (10217008)
1999
23
Clinical signs and symptoms of acute reflex sympathetic dystrophy in one hindlimb of the rat, induced by infusion of a free-radical donor. (9689763)
1998
24
Radiologic case study. Reflex sympathetic dystrophy. (9642714)
1998
25
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
26
Reflex sympathetic dystrophy. Outcome and measurement studies. Introduction. (9614808)
1998
27
Reflex sympathetic dystrophy: diagnostic controversies. (9467196)
1998
28
Reflex Sympathetic Dystrophy in the Upper Extremity. (10795066)
1997
29
Osteopenia, bone fragility and reflex sympathetic dystrophy syndrome in a man with ureterosigmoidostomy. (9373571)
1997
30
Somatic or sympathetic block for reflex sympathetic dystrophy. Which is indicated? (9279551)
1997
31
Osteopathic medical considerations of reflex sympathetic dystrophy. (9195791)
1997
32
Dual energy X-ray absorptiometry in reflex sympathetic dystrophy. (9101532)
1997
33
Extensive reflex sympathetic dystrophy syndrome of the lower limbs leading to a diagnosis of osteomalacia due to Fanconi syndrome. (9338939)
1997
34
Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb. (8783310)
1996
35
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8777019)
1996
36
Reflex sympathetic dystrophy syndrome following acute gouty arthritis. (8871842)
1996
37
Reflex sympathetic dystrophy with mutilating ulcerations suspicious of a factitial origin. (8912601)
1996
38
Prediction of reflex sympathetic dystrophy in hemiplegic patients by electromyographic study. (7491650)
1995
39
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8520215)
1995
40
Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material. (7892471)
1995
41
Contracture of the patellar tendon: an infrequently recognized complication of reflex sympathetic dystrophy of the knee. (7655874)
1995
42
Reflex sympathetic dystrophy syndrome: a longitudinal study. (7812335)
1994
43
Electromotive administration of guanethidine for treatment of reflex sympathetic dystrophy: a pilot study in eight patients. (8169459)
1994
44
Reflex sympathetic dystrophy. (8124658)
1994
45
A review of the autonomic nervous system and exploration of diagnoses associated with reflex sympathetic dystrophy. (7874244)
1994
46
Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. (8105263)
1993
47
Reflex sympathetic dystrophy. (8468902)
1993
48
Quantitative bone scintigraphy in reflex sympathetic dystrophy. (8422558)
1993
49
The use of 99Tcm-HSA dynamic vascular examination in the staging and therapy monitoring of reflex sympathetic dystrophy. (1780112)
1991
50
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988

Variations for Reflex Sympathetic Dystrophy

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Expression for genes affiliated with Reflex Sympathetic Dystrophy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reflex Sympathetic Dystrophy

Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.

Pathways for genes affiliated with Reflex Sympathetic Dystrophy

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CALCA, NPY
29.4NPY, CD36
3
Show member pathways
fatty acid beta-oxidation VI (peroxisome)39
9.1APOA1, CD36
4
Show member pathways
9.1APOA1, CD36
5
Show member pathways
9.1APOA1, CD36
6
Show member pathways
9.1APOA1, CD36
7
Show member pathways
8.9GABBR1, CALCA, NPY
8
Show member pathways
8.7APOA1, CALCA, NPY
9
Show member pathways
8.1NPY, GABBR1, CALCA, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 25HMDB
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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1calcitonin gene-related peptide469.9NPY, CALCA
2tiludronate46 52 1211.9CALCA, CD36
3helospectin469.9NPY, CALCA
4teriparatide46 1210.9CALCA, CD36
5etidronate469.9CALCA, CD36
6silver nitrate469.9CALCA, CD36
7ibandronate46 1210.9CALCA, CD36
8guanethidine46 1210.9NPY, CALCA
9calcium carbonate469.9CD36, CALCA
10tartrate469.9CALCA, CD36
11vitamin k2469.9CALCA, CD36
12pamidronate46 52 1211.9CD36, CALCA
13risedronate46 52 30 62 1213.9CD36, CALCA
14clodronate46 52 1211.8CD36, CALCA
15pyridinoline469.8CD36, CALCA
16isoflurane52 46 1211.8NPY, CALCA
17zoledronic acid469.8CD36, CALCA
18deoxypyridinoline469.8CD36, CALCA
19phosphoramidon46 1210.8CALCA, NPY
20pentylenetetrazol469.8GABBR1, NPY
21alendronate46 52 1211.7CD36, CALCA
22baclofen46 1210.7NPY, GABBR1
23muscimol46 62 3011.6GABBR1, NPY
24nandrolone decanoate46 1210.6APOA1, CALCA
25tibolone469.5CALCA, APOA1
26amphetamine46 52 1211.4NPY, GABBR1
275-hydroxytryptamine469.3NPY, GABBR1, CALCA
28norepinephrine46 25 1211.2CALCA, GABBR1, NPY
29histamine46 30 2511.2NPY, GABBR1, CALCA
30gnrh469.2GABBR1, NPY, CD36
31glibenclamide46 30 52 6212.2CALCA, APOA1
32hydroxyproline46 25 1211.2CD36, CALCA
33valproate469.2APOA1, GABBR1
34forskolin46 52 1211.1NPY, GABBR1, CALCA
3525-hydroxyvitamin d469.1CD36, CALCA, APOA1
36captopril46 62 52 30 1213.1CD36, CALCA, APOA1
37raloxifene46 52 30 1212.1APOA1, CALCA, CD36
38thyroxine46 2510.1APOA1, CALCA, NPY
39dopamine46 30 25 1212.1NPY, GABBR1, CALCA
40indomethacin46 30 62 1212.0APOA1, CALCA, NPY
41dextran sulfate469.0CD36, APOA1
42adenylate468.9NPY, GABBR1, CALCA
43pge2468.9APOA1, CALCA, CD36
44lactate468.9NPY, CALCA, APOA1
45cyclic amp46 259.9CALCA, GABBR1, NPY
46creatinine468.6CD36, NPY, CALCA, APOA1
47estrogen468.5CD36, NPY, CALCA, APOA1
48clonidine46 52 30 1211.5NPY, GABBR1, CALCA, APOA1
49acetylcholine46 52 30 25 1212.5APOA1, CALCA, GABBR1, NPY
50glutamate468.5APOA1, CALCA, GABBR1, NPY

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

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Sources:
17Gene Ontology
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Cellular components related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7NPY, CALCA, APOA1
2extracellular regionGO:0055767.8NPY, GABBR1, CALCA, APOA1

Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.6NPY, CALCA
2regulation of blood pressureGO:0082179.5CALCA, NPY
3endothelial cell proliferationGO:0019359.4CALCA, APOA1
4cholesterol transportGO:0303019.3APOA1, CD36
5lipid storageGO:0199159.2APOA1, CD36
6neuropeptide signaling pathwayGO:0072189.2CALCA, NPY
7cellular lipid metabolic processGO:0442559.1CD36, APOA1
8platelet degranulationGO:0025769.0APOA1, CD36

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:0080359.1CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

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  • Antibodies
  • Proteins
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Sources for Reflex Sympathetic Dystrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet