MCID: RFL001
MIFTS: 51

Reflex Sympathetic Dystrophy malady

Summaries for Reflex Sympathetic Dystrophy

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NINDS:44 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards based summary: Reflex Sympathetic Dystrophy, also known as syndrome, reflex sympathetic dystrophy, is related to osteomalacia and vascular disease. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Adipocytokine signaling pathway. The compounds calcitonin gene-related peptide and tiludronate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:65 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Aliases & Classifications for Reflex Sympathetic Dystrophy

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Sources:
10Disease Ontology, 12DISEASES, 45Novoseek, 62UMLS, 44NINDS, 57SNOMED-CT, 29ICD9CM, 40NCIt, 35MeSH
See all sources

Reflex Sympathetic Dystrophy, Aliases & Descriptions:

Name: Reflex Sympathetic Dystrophy 10 12 45 62
Syndrome, Reflex Sympathetic Dystrophy 62
 
Reflex Sympathetic Dystrophy Syndrome 44


External Ids:

Disease Ontology10 DOID:1811
NCIt40 C85042
MeSH35 D012019

Related Diseases for Reflex Sympathetic Dystrophy

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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Symptoms for Reflex Sympathetic Dystrophy

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Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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Drug clinical trials:

Search ClinicalTrials for Reflex Sympathetic Dystrophy

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

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Anatomical Context for Reflex Sympathetic Dystrophy

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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

33
Skin, Bone, Spinal cord, Testes, Bone marrow, Brain, Kidney, Breast

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CD36, NPY, CALCA
2MP:00053758.9GABBR1, NPY, CD36
3MP:00053868.4CALCA, GABBR1, NPY, CD36
4MP:00053708.3APOA1, NPY, CD36
5MP:00036318.3CD36, NPY, GABBR1, CALCA
6MP:00053767.6CD36, NPY, GABBR1, CALCA, APOA1

Publications for Reflex Sympathetic Dystrophy

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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
2
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. (17290576)
2006
3
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. (17182517)
2006
4
Segmental reflex sympathetic dystrophy. (16319634)
2005
5
Reflex sympathetic dystrophy and pancoast tumor. (15365437)
2004
6
Reflex sympathetic dystrophy of the foot: MRI with fat suppression is essential (letter with the drafting). (15474404)
2004
7
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
8
Reflex sympathetic dystrophy: a multidisciplinary approach. (15077274)
2004
9
Surgical sympathectomy for reflex sympathetic dystrophy syndromes. (11854724)
2002
10
Acupuncture improves peripheral perfusion in patients with reflex sympathetic dystrophy. (17039194)
2002
11
Re: The sequelae of reflex sympathetic dystrophy. (11895359)
2002
12
Reflex sympathetic dystrophy of the left hand and motor impairments of the unaffected right hand: impaired central motor processing? (11782836)
2002
13
Calcitonin in reflex sympathetic dystrophy syndrome and other painful conditions. (12008165)
2002
14
Technetium-99m sestamibi limb scintigraphy in post-traumatic reflex sympathetic dystrophy: preliminary results. (11685495)
2001
15
Thalamic perfusion in reflex sympathetic dystrophy syndrome. (10841150)
2000
16
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
17
Trans-tibial amputation for reflex sympathetic dystrophy: postoperative management. (10855442)
2000
18
Reflex sympathetic dystrophy following transbrachial cardiac catheterization. (10973376)
2000
19
Vitamin C prevents reflex sympathetic dystrophy. (10735491)
2000
20
Management of reflex sympathetic dystrophy. (10445091)
1999
21
Reflex sympathetic dystrophy in children. (10385843)
1999
22
Reflex sympathetic dystrophy in children: review of a clinical series and description of the particularities in children. (10217008)
1999
23
Clinical signs and symptoms of acute reflex sympathetic dystrophy in one hindlimb of the rat, induced by infusion of a free-radical donor. (9689763)
1998
24
Radiologic case study. Reflex sympathetic dystrophy. (9642714)
1998
25
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
26
Reflex sympathetic dystrophy. Outcome and measurement studies. Introduction. (9614808)
1998
27
Reflex sympathetic dystrophy: diagnostic controversies. (9467196)
1998
28
Reflex Sympathetic Dystrophy in the Upper Extremity. (10795066)
1997
29
Osteopenia, bone fragility and reflex sympathetic dystrophy syndrome in a man with ureterosigmoidostomy. (9373571)
1997
30
Somatic or sympathetic block for reflex sympathetic dystrophy. Which is indicated? (9279551)
1997
31
Osteopathic medical considerations of reflex sympathetic dystrophy. (9195791)
1997
32
Dual energy X-ray absorptiometry in reflex sympathetic dystrophy. (9101532)
1997
33
Extensive reflex sympathetic dystrophy syndrome of the lower limbs leading to a diagnosis of osteomalacia due to Fanconi syndrome. (9338939)
1997
34
Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb. (8783310)
1996
35
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8777019)
1996
36
Reflex sympathetic dystrophy syndrome following acute gouty arthritis. (8871842)
1996
37
Reflex sympathetic dystrophy with mutilating ulcerations suspicious of a factitial origin. (8912601)
1996
38
Prediction of reflex sympathetic dystrophy in hemiplegic patients by electromyographic study. (7491650)
1995
39
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8520215)
1995
40
Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material. (7892471)
1995
41
Contracture of the patellar tendon: an infrequently recognized complication of reflex sympathetic dystrophy of the knee. (7655874)
1995
42
Reflex sympathetic dystrophy syndrome: a longitudinal study. (7812335)
1994
43
Electromotive administration of guanethidine for treatment of reflex sympathetic dystrophy: a pilot study in eight patients. (8169459)
1994
44
Reflex sympathetic dystrophy. (8124658)
1994
45
A review of the autonomic nervous system and exploration of diagnoses associated with reflex sympathetic dystrophy. (7874244)
1994
46
Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. (8105263)
1993
47
Reflex sympathetic dystrophy. (8468902)
1993
48
Quantitative bone scintigraphy in reflex sympathetic dystrophy. (8422558)
1993
49
The use of 99Tcm-HSA dynamic vascular examination in the staging and therapy monitoring of reflex sympathetic dystrophy. (1780112)
1991
50
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988

Variations for Reflex Sympathetic Dystrophy

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Expression for genes affiliated with Reflex Sympathetic Dystrophy

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Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.

Pathways for genes affiliated with Reflex Sympathetic Dystrophy

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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NPY, CALCA
29.4CD36, NPY
3
Show member pathways
9.1CD36, APOA1
4
Show member pathways
fatty acid beta-oxidation VI (peroxisome)38
9.1CD36, APOA1
5
Show member pathways
9.1APOA1, CD36
6
Show member pathways
9.1CD36, APOA1
7
Show member pathways
8.9CALCA, GABBR1, NPY
8
Show member pathways
8.7APOA1, CALCA, NPY
9
Show member pathways
8.1NPY, GABBR1, CALCA, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1calcitonin gene-related peptide459.9NPY, CALCA
2tiludronate45 51 1311.9CALCA, CD36
3helospectin459.9NPY, CALCA
4teriparatide45 1310.9CALCA, CD36
5etidronate459.9CALCA, CD36
6silver nitrate459.9CALCA, CD36
7ibandronate45 1310.9CALCA, CD36
8guanethidine45 1310.9NPY, CALCA
9calcium carbonate459.9CD36, CALCA
10tartrate459.9CALCA, CD36
11vitamin k2459.9CALCA, CD36
12pamidronate45 51 1311.9CD36, CALCA
13risedronate45 51 30 61 1313.9CD36, CALCA
14clodronate45 51 1311.8CD36, CALCA
15pyridinoline459.8CD36, CALCA
16isoflurane51 45 1311.8NPY, CALCA
17zoledronic acid459.8CD36, CALCA
18deoxypyridinoline459.8CD36, CALCA
19phosphoramidon45 1310.8CALCA, NPY
20pentylenetetrazol459.8GABBR1, NPY
21alendronate45 51 1311.7CD36, CALCA
22baclofen45 1310.7NPY, GABBR1
23muscimol45 61 3011.6GABBR1, NPY
24nandrolone decanoate45 1310.6APOA1, CALCA
25tibolone459.5CALCA, APOA1
26amphetamine45 51 1311.4NPY, GABBR1
275-hydroxytryptamine459.3NPY, GABBR1, CALCA
28norepinephrine45 26 1311.2CALCA, GABBR1, NPY
29histamine45 30 2611.2NPY, GABBR1, CALCA
30gnrh459.2GABBR1, NPY, CD36
31glibenclamide45 30 51 6112.2CALCA, APOA1
32hydroxyproline45 26 1311.2CD36, CALCA
33valproate459.2APOA1, GABBR1
34forskolin45 51 1311.1NPY, GABBR1, CALCA
3525-hydroxyvitamin d459.1CD36, CALCA, APOA1
36captopril45 61 51 30 1313.1CD36, CALCA, APOA1
37raloxifene45 51 30 1312.1APOA1, CALCA, CD36
38thyroxine45 2610.1APOA1, CALCA, NPY
39dopamine45 30 26 1312.1NPY, GABBR1, CALCA
40indomethacin45 30 61 1312.0APOA1, CALCA, NPY
41dextran sulfate459.0CD36, APOA1
42adenylate458.9NPY, GABBR1, CALCA
43pge2458.9APOA1, CALCA, CD36
44lactate458.9NPY, CALCA, APOA1
45cyclic amp45 269.9CALCA, GABBR1, NPY
46creatinine458.6CD36, NPY, CALCA, APOA1
47estrogen458.5CD36, NPY, CALCA, APOA1
48clonidine45 51 30 1311.5NPY, GABBR1, CALCA, APOA1
49acetylcholine45 51 30 26 1312.5APOA1, CALCA, GABBR1, NPY
50glutamate458.5APOA1, CALCA, GABBR1, NPY

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

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Cellular components related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056158.7NPY, CALCA, APOA1
2extracellular regionGO:00055767.8NPY, GABBR1, CALCA, APOA1

Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:00076319.6NPY, CALCA
2regulation of blood pressureGO:00082179.5CALCA, NPY
3endothelial cell proliferationGO:00019359.4CALCA, APOA1
4cholesterol transportGO:00303019.3CD36, APOA1
5lipid storageGO:00199159.2CD36, APOA1
6neuropeptide signaling pathwayGO:00072189.2NPY, CALCA
7cellular lipid metabolic processGO:00442559.1CD36, APOA1
8platelet degranulationGO:00025769.0CD36, APOA1

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:00080359.1CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

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Sources for Reflex Sympathetic Dystrophy

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet