MCID: RFL001
MIFTS: 52

Reflex Sympathetic Dystrophy malady

Neuronal diseases category
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Summaries for Reflex Sympathetic Dystrophy

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NINDS:43 Complex regional pain syndrome (CRPS) is a chronic pain condition. The key symptom of CRPS is continuous, intense pain out of proportion to the severity of the injury, which gets worse rather than better over time. CRPS most often affects one of the arms, legs, hands, or feet. Often the pain spreads to include the entire arm or leg. Typical features include dramatic changes in the color and temperature of the skin over the affected limb or body part, accompanied by intense burning pain, skin sensitivity, sweating, and swelling. Doctors aren?t sure what causes CRPS. In some cases the sympathetic nervous system plays an important role in sustaining the pain. Another theory is that CRPS is caused by a triggering of the immune response, which leads to the characteristic inflammatory symptoms of redness, warmth, and swelling in the affected area.

MalaCards based summary: Reflex Sympathetic Dystrophy, also known as syndrome, reflex sympathetic dystrophy, is related to osteomalacia and vascular disease. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Adipocytokine signaling pathway. The compounds calcitonin gene-related peptide and tiludronate have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and spinal cord, and related mouse phenotypes are renal/urinary system and adipose tissue.

Wikipedia:65 Complex regional pain syndrome (CRPS) formerly reflex sympathetic dystrophy (RSD), \"causalgia\", or... more...

Description from OMIM:46 604335

Aliases & Classifications for Reflex Sympathetic Dystrophy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 43NINDS, 57SNOMED-CT, 27ICD9CM, 46OMIM, 39NCIt, 34MeSH
See all sources

Reflex Sympathetic Dystrophy, Aliases & Descriptions:

Name: Reflex Sympathetic Dystrophy 8 10 44 62
Syndrome, Reflex Sympathetic Dystrophy 62
 
Reflex Sympathetic Dystrophy Syndrome 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:1811
OMIM46 604335
NCIt39 C85042
MeSH34 D012019

Related Diseases for Reflex Sympathetic Dystrophy

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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Symptoms for Reflex Sympathetic Dystrophy

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Clinical features from OMIM:

604335

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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Drug clinical trials:

Search ClinicalTrials for Reflex Sympathetic Dystrophy

Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

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Anatomical Context for Reflex Sympathetic Dystrophy

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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

32
Skin, Bone, Spinal cord, Testes, Bone marrow, Brain, Breast

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

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MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053679.0CD36, NPY, CALCA
2MP:00053758.9GABBR1, NPY, CD36
3MP:00053868.4CALCA, GABBR1, NPY, CD36
4MP:00053708.3APOA1, NPY, CD36
5MP:00036318.3CD36, NPY, GABBR1, CALCA
6MP:00053767.6CD36, NPY, GABBR1, CALCA, APOA1

Publications for Reflex Sympathetic Dystrophy

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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
2
Psychiatric approach in the treatment of reflex sympathetic dystrophy in an adolescent girl: a case report. (17290576)
2006
3
The role of the pain psychologist, trigger point injections, reflex sympathetic dystrophy. (17182517)
2006
4
Segmental reflex sympathetic dystrophy. (16319634)
2005
5
Reflex sympathetic dystrophy and pancoast tumor. (15365437)
2004
6
Reflex sympathetic dystrophy of the foot: MRI with fat suppression is essential (letter with the drafting). (15474404)
2004
7
Stress infrared telethermography is useful in the diagnosis of complex regional pain syndrome, Type I (formerly reflex sympathetic dystrophy). (17271895)
2004
8
Reflex sympathetic dystrophy: a multidisciplinary approach. (15077274)
2004
9
Surgical sympathectomy for reflex sympathetic dystrophy syndromes. (11854724)
2002
10
Acupuncture improves peripheral perfusion in patients with reflex sympathetic dystrophy. (17039194)
2002
11
Re: The sequelae of reflex sympathetic dystrophy. (11895359)
2002
12
Reflex sympathetic dystrophy of the left hand and motor impairments of the unaffected right hand: impaired central motor processing? (11782836)
2002
13
Calcitonin in reflex sympathetic dystrophy syndrome and other painful conditions. (12008165)
2002
14
Technetium-99m sestamibi limb scintigraphy in post-traumatic reflex sympathetic dystrophy: preliminary results. (11685495)
2001
15
Thalamic perfusion in reflex sympathetic dystrophy syndrome. (10841150)
2000
16
Reflex sympathetic dystrophy, sympathetically maintained pain, and complex regional pain syndrome: diagnoses of inclusion, exclusion, or confusion? (11129251)
2000
17
Trans-tibial amputation for reflex sympathetic dystrophy: postoperative management. (10855442)
2000
18
Reflex sympathetic dystrophy following transbrachial cardiac catheterization. (10973376)
2000
19
Vitamin C prevents reflex sympathetic dystrophy. (10735491)
2000
20
Management of reflex sympathetic dystrophy. (10445091)
1999
21
Reflex sympathetic dystrophy in children. (10385843)
1999
22
Reflex sympathetic dystrophy in children: review of a clinical series and description of the particularities in children. (10217008)
1999
23
Clinical signs and symptoms of acute reflex sympathetic dystrophy in one hindlimb of the rat, induced by infusion of a free-radical donor. (9689763)
1998
24
Radiologic case study. Reflex sympathetic dystrophy. (9642714)
1998
25
Interrupting the sympathetic outflow in causalgia and reflex sympathetic dystrophy. Intravenous regional guanethidine blockage is a safe and effective treatment. (9841006)
1998
26
Reflex sympathetic dystrophy. Outcome and measurement studies. Introduction. (9614808)
1998
27
Reflex sympathetic dystrophy: diagnostic controversies. (9467196)
1998
28
Reflex Sympathetic Dystrophy in the Upper Extremity. (10795066)
1997
29
Osteopenia, bone fragility and reflex sympathetic dystrophy syndrome in a man with ureterosigmoidostomy. (9373571)
1997
30
Somatic or sympathetic block for reflex sympathetic dystrophy. Which is indicated? (9279551)
1997
31
Osteopathic medical considerations of reflex sympathetic dystrophy. (9195791)
1997
32
Dual energy X-ray absorptiometry in reflex sympathetic dystrophy. (9101532)
1997
33
Extensive reflex sympathetic dystrophy syndrome of the lower limbs leading to a diagnosis of osteomalacia due to Fanconi syndrome. (9338939)
1997
34
Multiple reflex sympathetic dystrophy. Which patients are at risk for developing a recurrence of reflex sympathetic dystrophy in the same or another limb. (8783310)
1996
35
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8777019)
1996
36
Reflex sympathetic dystrophy syndrome following acute gouty arthritis. (8871842)
1996
37
Reflex sympathetic dystrophy with mutilating ulcerations suspicious of a factitial origin. (8912601)
1996
38
Prediction of reflex sympathetic dystrophy in hemiplegic patients by electromyographic study. (7491650)
1995
39
Sympathetic skin response in patients with reflex sympathetic dystrophy. (8520215)
1995
40
Reflex sympathetic dystrophy revisited: MR imaging findings before and after infusion of contrast material. (7892471)
1995
41
Reflex sympathetic dystrophy syndrome: a longitudinal study. (7812335)
1994
42
Electromotive administration of guanethidine for treatment of reflex sympathetic dystrophy: a pilot study in eight patients. (8169459)
1994
43
Reflex sympathetic dystrophy. (8124658)
1994
44
A review of the autonomic nervous system and exploration of diagnoses associated with reflex sympathetic dystrophy. (7874244)
1994
45
Signs and symptoms of reflex sympathetic dystrophy: prospective study of 829 patients. (8105263)
1993
46
Reflex sympathetic dystrophy. (8468902)
1993
47
Quantitative bone scintigraphy in reflex sympathetic dystrophy. (8422558)
1993
48
Is hyperlipidaemia a contributing factor to algodystrophy (reflex sympathetic dystrophy)? (1486745)
1992
49
The use of 99Tcm-HSA dynamic vascular examination in the staging and therapy monitoring of reflex sympathetic dystrophy. (1780112)
1991
50
Burning and pain after injury. Is it causalgia or reflex sympathetic dystrophy? (3340606)
1988

Variations for Reflex Sympathetic Dystrophy

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Expression for genes affiliated with Reflex Sympathetic Dystrophy

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Expression patterns in normal tissues for genes affiliated with Reflex Sympathetic Dystrophy

Search GEO for disease gene expression data for Reflex Sympathetic Dystrophy.

Pathways for genes affiliated with Reflex Sympathetic Dystrophy

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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5CALCA, NPY
29.4NPY, CD36
3
Show member pathways
fatty acid beta-oxidation VI (peroxisome)37
9.1APOA1, CD36
4
Show member pathways
9.1APOA1, CD36
5
Show member pathways
9.1APOA1, CD36
6
Show member pathways
9.1APOA1, CD36
7
Show member pathways
8.9GABBR1, CALCA, NPY
8
Show member pathways
8.7APOA1, CALCA, NPY
9
Show member pathways
8.1NPY, GABBR1, CALCA, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 81)
idCompoundScoreTop Affiliating Genes
1calcitonin gene-related peptide449.9NPY, CALCA
2tiludronate44 50 1111.9CD36, CALCA
3helospectin449.9NPY, CALCA
4etidronate449.9CD36, CALCA
5teriparatide44 1110.9CALCA, CD36
6ibandronate44 1110.9CD36, CALCA
7silver nitrate449.9CD36, CALCA
8guanethidine44 1110.9NPY, CALCA
9calcium carbonate449.9CD36, CALCA
10vitamin k2449.9CALCA, CD36
11tartrate449.9CALCA, CD36
12pamidronate44 50 1111.9CD36, CALCA
13risedronate44 50 28 61 1113.9CALCA, CD36
14clodronate44 50 1111.8CALCA, CD36
15pyridinoline449.8CALCA, CD36
16zoledronic acid449.8CALCA, CD36
17deoxypyridinoline449.8CALCA, CD36
18isoflurane50 44 1111.8NPY, CALCA
19phosphoramidon44 1110.8NPY, CALCA
20pentylenetetrazol449.8GABBR1, NPY
21alendronate44 50 1111.7CALCA, CD36
22baclofen44 1110.7NPY, GABBR1
23muscimol44 61 2811.6GABBR1, NPY
24nandrolone decanoate44 1110.6APOA1, CALCA
25tibolone449.5CALCA, APOA1
26amphetamine44 50 1111.4GABBR1, NPY
275-hydroxytryptamine449.3CALCA, GABBR1, NPY
28norepinephrine44 24 1111.2NPY, GABBR1, CALCA
29histamine44 28 2411.2NPY, CALCA, GABBR1
30gnrh449.2GABBR1, NPY, CD36
31glibenclamide44 28 50 6112.2APOA1, CALCA
32hydroxyproline44 24 1111.2CD36, CALCA
33valproate449.2APOA1, GABBR1
34forskolin44 50 1111.1CALCA, NPY, GABBR1
3525-hydroxyvitamin d449.1CALCA, CD36, APOA1
36captopril44 61 50 28 1113.1CD36, CALCA, APOA1
37raloxifene44 50 28 1112.1CALCA, CD36, APOA1
38thyroxine44 2410.1CALCA, NPY, APOA1
39dopamine44 28 24 1112.1GABBR1, CALCA, NPY
40indomethacin44 28 61 1112.0CALCA, NPY, APOA1
41dextran sulfate449.0CD36, APOA1
42adenylate448.9CALCA, NPY, GABBR1
43pge2448.9CD36, CALCA, APOA1
44cyclic amp44 249.9NPY, GABBR1, CALCA
45lactate448.9CALCA, APOA1, NPY
46creatinine448.6CALCA, CD36, NPY, APOA1
47estrogen448.5CD36, NPY, CALCA, APOA1
48clonidine44 50 28 1111.5NPY, GABBR1, CALCA, APOA1
49acetylcholine44 50 28 24 1112.5APOA1, CALCA, NPY, GABBR1
50glutamate448.5APOA1, NPY, GABBR1, CALCA

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

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Cellular components related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:0056158.7NPY, CALCA, APOA1
2extracellular regionGO:0055767.8NPY, GABBR1, CALCA, APOA1

Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1feeding behaviorGO:0076319.6NPY, CALCA
2regulation of blood pressureGO:0082179.5CALCA, NPY
3endothelial cell proliferationGO:0019359.4CALCA, APOA1
4cholesterol transportGO:0303019.3APOA1, CD36
5lipid storageGO:0199159.2APOA1, CD36
6neuropeptide signaling pathwayGO:0072189.2CALCA, NPY
7cellular lipid metabolic processGO:0442559.1CD36, APOA1
8platelet degranulationGO:0025769.0APOA1, CD36

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:0080359.1CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

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Sources for Reflex Sympathetic Dystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet