MCID: RFL001
MIFTS: 43

Reflex Sympathetic Dystrophy malady

Summaries for Reflex Sympathetic Dystrophy

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46OMIM, 32MalaCards
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MalaCards: Reflex Sympathetic Dystrophy is related to complex regional pain syndrome and neuropathy. An important gene associated with Reflex Sympathetic Dystrophy is CALCA (calcitonin-related polypeptide alpha), and among its related pathways are Endothelin and Fat digestion and absorption. The compounds gnrh and pamidronate have been mentioned in the context of this disorder. Affiliated tissues include bone, spinal cord and skin, and related mouse phenotype homeostasis/metabolism.

Description from OMIM:46 604335

Aliases & Classifications for Reflex Sympathetic Dystrophy

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 46OMIM, 34MeSH
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Aliases & Descriptions:

reflex sympathetic dystrophy 8 60


External Ids:

Disease Ontology8 DOID:1811
NCIt39 C85042
OMIM46 604335
MeSH34 D012019

Related Diseases for Reflex Sympathetic Dystrophy

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Reflex Sympathetic Dystrophy:



Diseases related to reflex sympathetic dystrophy

Clinical Features for Reflex Sympathetic Dystrophy

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46OMIM
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Clinical features from OMIM:

604335

Drugs & Therapeutics for Reflex Sympathetic Dystrophy

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Reflex Sympathetic Dystrophy

Drug clinical trials:

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Search NIH Clinical Center for Reflex Sympathetic Dystrophy

Search CenterWatch for Reflex Sympathetic Dystrophy

Genetic Tests for Reflex Sympathetic Dystrophy

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Anatomical Context for Reflex Sympathetic Dystrophy

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32MalaCards
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MalaCards organs/tissues related to Reflex Sympathetic Dystrophy:

32
Bone, Spinal cord, Skin, Testes, Bone marrow, Brain, Kidney, Breast

Animal Models for Reflex Sympathetic Dystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Reflex Sympathetic Dystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.3CD36, PRSS50, GABBR1, NPY, APOA1, CALCA

Publications for Reflex Sympathetic Dystrophy

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50PubMed
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Articles related to Reflex Sympathetic Dystrophy:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Reply: Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? (20583223)
2010
2
Complex regional pain syndrome/reflex sympathetic dystrophy. (20504141)
2010
3
Reflex sympathetic dystrophy secondary to deep venous thrombosis mimicking post-thrombotic syndrome. (19363611)
2009
4
Reflex sympathetic dystrophy: a retrospective epidemiological study of 168 patients. (17221145)
2007
5
Reflex sympathetic dystrophy: reflections from a clinician. (18605399)
2007
6
Interobserver reproducibility in the interpretation of bone scans from patients suspected of having reflex sympathetic dystrophy. (15604958)
2005
7
A new clinical severity scoring system for reflex sympathetic dystrophy of the upper limb. (15142707)
2004
8
Reflex sympathetic dystrophy after routine venipuncture. (15473597)
2004
9
Radiologic case study. Reflex sympathetic dystrophy syndrome. (15058446)
2004
10
Scoring system in the assessment of the clinical severity of reflex sympathetic dystrophy of the hand. (12945650)
2003
11
Ureaplasma urealyticum as a possible cause of reflex sympathetic dystrophy syndrome. (12109655)
2002
12
Twitch-obtaining intramuscular stimulation in reflex sympathetic dystrophy. (12168246)
2002
13
Is fibromyalgia a generalized reflex sympathetic dystrophy? (11247309)
2001
14
Reflex sympathetic dystrophy. (11511699)
2001
15
Thalamic perfusion in reflex sympathetic dystrophy syndrome. (10841150)
2000
16
Vitamin C prevents reflex sympathetic dystrophy. (10735491)
2000
17
Recurrent and migratory reflex sympathetic dystrophy in children. (11469747)
2000
18
Reflex sympathetic dystrophy: misdiagnosis in patients with dysfunctional postures of the upper extremity. (11119678)
2000
19
Explaining reflex sympathetic dystrophy. (10328244)
1999
20
HLA-DQ1 associated with reflex sympathetic dystrophy. (10522900)
1999
21
Clinical signs and symptoms of acute reflex sympathetic dystrophy in one hindlimb of the rat, induced by infusion of a free-radical donor. (9689763)
1998
22
Radiologic case study. Reflex sympathetic dystrophy. (9642714)
1998
23
Reflex sympathetic dystrophy: diagnostic controversies. (9467196)
1998
24
The reasons for poor response to treatment of posttraumatic reflex sympathetic dystrophy. (9828479)
1998
25
Traumatic neuralgias: complex regional pain syndromes (reflex sympathetic dystrophy and causalgia): clinical characteristics, pathophysiological mechanisms and therapy. (9767066)
1998
26
Reflex sympathetic dystrophy following vascular access surgery for haemodialysis: influence of peripheral ischaemia? (9550671)
1998
27
Variation in measurements of range of motion: a study in reflex sympathetic dystrophy patients. (9688042)
1998
28
Reflex sympathetic dystrophy and pain dysfunction in the lower extremity. (9384438)
1997
29
Reflex sympathetic dystrophy of the upper extremity. Clinical features and response to multimodal management. (9279539)
1997
30
Movement disorder in reflex sympathetic dystrophy: a case proven to be psychogenic by surveillance video monitoring. (9087986)
1997
31
Axillary brachial plexus blockade for the reflex sympathetic dystrophy syndrome. (9459103)
1997
32
Urological symptomatology in patients with reflex sympathetic dystrophy. (8558679)
1996
33
Psychological differences between reflex sympathetic dystrophy and non-RSD chronic pain patients. (8895237)
1996
34
Long-term use of subarachnoid clonidine for analgesia in refractory reflex sympathetic dystrophy. Case report. (8744669)
1996
35
Re: Long-term treatment of intractable reflex sympathetic dystrophy with intrathecal morphine. (8738931)
1996
36
Reflex sympathetic dystrophy. (7783904)
1995
37
Value of autonomic testing in reflex sympathetic dystrophy. (7475332)
1995
38
The clenched fist syndrome. A psychiatric syndrome mimicking reflex sympathetic dystrophy. (7818573)
1995
39
Lesson of the week. Reflex sympathetic dystrophy in children. (7795455)
1995
40
Case reports and hypothesis: a neglect-like syndrome may be responsible for the motor disturbance in reflex sympathetic dystrophy (Complex Regional Pain Syndrome-1). (7673771)
1995
41
Case report: short tau inversion recovery (STIR) sequence MRI appearances of reflex sympathetic dystrophy. (7889713)
1995
42
Reflex sympathetic dystrophy syndrome: a longitudinal study. (7812335)
1994
43
Stability of temperature asymmetries in reflex sympathetic dystrophy over time and changes in pain. (8193447)
1994
44
Laboratory findings in reflex sympathetic dystrophy: a preliminary report. (7833582)
1994
45
Reflex sympathetic dystrophy of the head: case report and discussion of diagnostic criteria. (8295237)
1994
46
Reflex sympathetic dystrophy following total knee replacement. (10150250)
1994
47
Reflex sympathetic dystrophy after bone marrow transplantation. (8241348)
1993
48
The association of peripheral nerve compression and reflex sympathetic dystrophy. (8345262)
1993
49
Ketorolac in reflex sympathetic dystrophy. (8422662)
1993
50
Epithelioid hemangioendothelioma associated with reflex sympathetic dystrophy. (1569252)
1992

Genetic Variations for Reflex Sympathetic Dystrophy

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Expression for genes affiliated with Reflex Sympathetic Dystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reflex Sympathetic Dystrophy

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Pathways for genes affiliated with Reflex Sympathetic Dystrophy

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37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8NPY, CALCA
29.4CD36, APOA1
39.4CD36, APOA1

Compounds for genes affiliated with Reflex Sympathetic Dystrophy

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44Novoseek, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB
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Compounds related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1gnrh4410.3GABBR1
2pamidronate44 49 1112.2CD36
3calcitonin gene-related peptide4410.2NPY, CALCA
4helospectin4410.2NPY, CALCA
5guanethidine44 1111.2NPY, CALCA
6nandrolone decanoate44 1111.1CALCA, APOA1
7isoflurane44 1111.1CALCA, NPY
8tibolone4410.0CALCA, APOA1
9phosphoramidon44 1111.0CALCA, NPY
10pentylenetetrazol4410.0NPY, GABBR1
11baclofen44 1110.9NPY, GABBR1
12tiludronate44 49 1111.9CALCA, CD36
13teriparatide44 1110.9CALCA, CD36
14etidronate449.9CALCA, CD36
15silver nitrate449.9CALCA, CD36
16ibandronate44 1110.9CALCA, CD36
17calcium carbonate449.9CD36, CALCA
18muscimol44 59 2811.9GABBR1, NPY
19tartrate449.9CD36, CALCA
20vitamin k2449.9CD36, CALCA
21risedronate44 59 49 28 1113.9CD36, CALCA
22clodronate44 49 1111.9CD36, CALCA
23pyridinoline449.8CD36, CALCA
24zoledronic acid449.8CALCA, CD36
25deoxypyridinoline449.8CALCA, CD36
26alendronate44 49 1111.7CD36, CALCA
27thyroxine44 2410.7CALCA, APOA1, NPY
28glibenclamide44 28 49 5912.7APOA1, CALCA
29amphetamine44 1110.6GABBR1, NPY
305-hydroxytryptamine449.6GABBR1, NPY, CALCA
31valproate449.6APOA1, GABBR1
32indomethacin44 59 28 1112.6NPY, APOA1, CALCA
3325-hydroxyvitamin d449.5CALCA, APOA1, CD36
34captopril44 28 49 59 1113.5CD36, APOA1, CALCA
35raloxifene44 28 49 1112.5CALCA, APOA1, CD36
36norepinephrine44 11 2411.4GABBR1, NPY, CALCA
37histamine44 28 2411.4CALCA, NPY, GABBR1
38dextran sulfate449.3APOA1, CD36
39forskolin44 49 1111.2GABBR1, NPY, CALCA
40clonidine44 28 1111.2GABBR1, NPY, APOA1, CALCA
41hydroxyproline44 11 2411.2CD36, CALCA
42acetylcholine44 49 28 11 2413.2GABBR1, NPY, APOA1, CALCA
43glutamate449.1GABBR1, NPY, APOA1, CALCA
44creatinine449.1CALCA, APOA1, NPY, CD36
45estrogen448.8CD36, NPY, APOA1, CALCA

GO Terms for genes affiliated with Reflex Sympathetic Dystrophy

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16Gene Ontology
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Biological processes related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:0082179.8NPY, CALCA
2endothelial cell proliferationGO:0019359.7APOA1, CALCA
3feeding behaviorGO:0076319.5NPY, CALCA
4cholesterol transportGO:0303019.4CD36, APOA1
5lipid storageGO:0199159.3APOA1, CD36

Molecular functions related to Reflex Sympathetic Dystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1high-density lipoprotein particle bindingGO:0080359.4CD36, APOA1

Products for genes affiliated with Reflex Sympathetic Dystrophy

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  • Antibodies
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Sources for Reflex Sympathetic Dystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet