MCID: RFR003
MIFTS: 53

Refractive Error malady

Eye diseases category

Summaries for Refractive Error

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The cornea and lens of your eye helps you focus. refractive errors are vision problems that happen when the shape of the eye keeps you from focusing well. the cause could be the length of the eyeball (longer or shorter), changes in the shape of the cornea, or aging of the lens. four common refractive errors are myopia, or nearsightedness - clear vision close up but blurry in the distance hyperopia, or farsightedness - clear vision in the distance but blurry close up presbyopia - inability to focus close up as a result of aging astigmatism - focus problems caused by the cornea the most common symptom is blurred vision. other symptoms may include double vision, haziness, glare or halos around bright lights, squinting, headaches, or eye strain. glasses or contact lenses can usually correct refractive errors. laser eye surgery may also be a possibility. nih: national eye institute

MalaCards: Refractive Error, also known as refractive errors, is related to retinitis and keratoconus. An important gene associated with Refractive Error is RHO (rhodopsin), and among its related pathways are Degradation of collagen and Syndecan-1-mediated signaling events. The compounds procollagen and n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

Wikipedia:63 A refractive error, or refraction error, is an error in the focusing of light by the eye and a frequent... more...

Aliases & Classifications for Refractive Error

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

refractive error 8 10
refractive errors 44 33 60
eye refraction disorder 8
disorder of refraction 8


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Disease Ontology8 DOID:9835
MeSH34 D012030
NCIt39 C87145
ICD1025 H52.6

Related Diseases for Refractive Error

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Refractive Error:



Diseases related to refractive error

Clinical Features for Refractive Error

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Drugs & Therapeutics for Refractive Error

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Refractive Error

Search CenterWatch for Refractive Error

Genetic Tests for Refractive Error

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Anatomical Context for Refractive Error

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32MalaCards
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MalaCards organs/tissues related to Refractive Error:

32
Eye, Testes, Endothelial, Retina

Animal Models for Refractive Error or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Refractive Error:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.1GJD2, NF2
2MP:000538810.0VIP, TIMP3, MET, NF2, MMP14, MMP10
3MP:000539110.0TIMP3, FMOD, MET, RHO, NF2, MMP14
4MP:00053789.9FMOD, MET, NF2, MMP13, MMP14, MMP7
5MP:00053859.9ACTC1, VIP, TIMP4, TIMP3, FMOD, MET
6MP:00053879.9RHO, MET, FMOD, TIMP3, VIP, NF2
7MP:00053769.8RHO, MET, TIMP3, TIMP4, VIP, NF2

Publications for Refractive Error

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50PubMed
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Articles related to Refractive Error:

(show top 50)    (show all 538)
idTitleAuthorsYear
1
Matrix metalloproteinases and educational attainment in refractive error: evidence of gene-environment interactions in the Age-Related Eye Disease Study. (23098370)
2013
2
Development of refractive error in individual children with regressed retinopathy of prematurity. (23920368)
2013
3
Postoperative refractive error following cataract surgery after the first attack of acute primary angle closure. (24234424)
2013
4
Diurnal rhythms of spherical refractive error, optical axial length, and power in the chick. (22893678)
2012
5
To avoid post-operative refractive error in cataract surgery. (23960979)
2012
6
Relative peripheral refractive error and the risk of onset and progression of myopia in children. (20739476)
2011
7
A perfluoropolyether corneal inlay for the correction of refractive error. (21306775)
2011
8
Relationship between conjunctivochalasis and refractive error. (21301349)
2011
9
Shorter axial length and increased astigmatic refractive error are associated With socio-economic deprivation in an adult UK cohort. (21091202)
2011
10
Effects of the intraocular lens type on refractive error following phacovitrectomy with gas tamponade. (22029869)
2011
11
Correlation between refractive error, corneal power, and thickness in a large population with a wide range of ametropia. (21051694)
2011
12
Success rates of retinal buckling surgery: relationship to refractive error and lens status: results from a large German case series. (20207006)
2010
13
Frequency, course, and impact of correctable visual impairment (uncorrected refractive error). (20850856)
2010
14
A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. (20835236)
2010
15
Correction of residual refractive error in pseudophakic eyes with the use of a secondary piggyback toricImplantable Collamer Lens. (20506959)
2010
16
Validation of a visual function and quality of life instrument in an urban Indian population with uncorrected refractive error using Rasch analysis. (20868254)
2010
17
Uncorrected refractive errors, presbyopia and spectacle coverage: results from a rapid assessment of refractive error survey. (19874105)
2009
18
Standardized patient methodology to assess refractive error reproducibility. (19319010)
2009
19
Refractive error changes in children with intermittent exotropia under overminus lens therapy. (20098893)
2009
20
Epithelial removal and phototherapeutic keratectomy for residual refractive error following LASIK in eyes with corneal epithelial basement membrane degeneration. (19714797)
2009
21
Screening for refractive error and fitting with spectacles in rural and urban India: cost-effectiveness. (19995203)
2009
22
Strategies to improve the accuracy of vision measurement by teachers in rural Chinese secondary schoolchildren: Xichang Pediatric Refractive Error Study (X-PRES) report no. 6. (18852423)
2008
23
Visual disability, visual function, and myopia among rural chinese secondary school children: the Xichang Pediatric Refractive Error Study (X-PRES)--report 1. (18378579)
2008
24
Prediction of refractive error in combined vitrectomy and cataract surgery with one-piece acrylic intraocular lens. (19096237)
2008
25
Prevalence of refractive error in school children of Karachi. (18988392)
2008
26
Useful resources: refractive error. (17971918)
2007
27
Prevalence of refractive error and attitude to spectacle use among drivers of public institutions in Ibadan, Nigeria. (18240488)
2007
28
The effect of overnight contact lens corneal reshaping on refractive error-specific quality of life. (16772893)
2006
29
The association of astigmatism and spherical refractive error in a high myopia cohort. (15829852)
2005
30
Optic disk size correlated with refractive error. (16310499)
2005
31
Use of refractive direct ophthalmoscopy for estimation of refractive error. (15853857)
2005
32
Photorefractive keratectomy for pediatric anisometropia: safety and impact on refractive error, visual acuity, and stereopsis. (15234284)
2004
33
Undercorrected refractive error in Singaporean Chinese adults: the Tanjong Pagar survey. (15582070)
2004
34
Development of the National Eye Institute refractive error correction quality of life questionnaire: focus groups. (14644709)
2003
35
Refractive error and ethnicity in children. (12912692)
2003
36
Population-based assessment of refractive error in India: the Andhra Pradesh eye disease study. (11886410)
2002
37
Artificial cornea: towards a synthetic onlay for correction of refractive error. (11900325)
2001
38
Aggregation of refractive error and 5-year changes in refractive error among families in the Beaver Dam Eye Study. (11709020)
2001
39
Does cryotherapy affect refractive error? Results from treated versus control eyes in the cryotherapy for retinopathy of prematurity trial. (11158812)
2001
40
Refractive error in cataract surgery after previous refractive surgery. (10646161)
2000
41
Disparity between refractive error and visual acuity after photorefractive keratectomy: multifocal corneal effects. (9379373)
1997
42
Power vectors: an application of Fourier analysis to the description and statistical analysis of refractive error. (9255814)
1997
43
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
44
Optic nerve crescents and refractive error. (1565418)
1992
45
Exploring the optometric application of expert computer systems: refractive error correction. (1813572)
1991
46
Effects of intraocular lens position errors on postoperative refractive error. (2355315)
1990
47
Survey of spectacle wear and refractive error prevalence in USAF pilots and navigators. (2250892)
1990
48
The effect of test proximity and induced refractive error on stereoacuity. (3688183)
1987
49
Screening of infants for strabismus and refractive errors with two-flash photorefraction with and without cycloplegia. (3811870)
1986
50
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985

Genetic Variations for Refractive Error

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Expression for genes affiliated with Refractive Error

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Refractive Error

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Pathways for genes affiliated with Refractive Error

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53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Refractive Error

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44Novoseek, 11DrugBank, 49PharmGKB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Refractive Error according to GeneCards/GeneDecks:

(show all 42)
idCompoundScoreTop Affiliating Genes
1procollagen4410.7FMOD
2n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1111.7MMP10, MMP12, MMP20
3(4-aminophenyl)mercuric acetate4410.7MMP13, MMP10, MMP8, MMP7
4barbiturate4410.6MMP8, MMP13
5clodronate44 49 1112.6MMP13, MMP14, MMP8
6fluoroaluminate4410.6RHO, VIP
7tetracycline44 1111.6MMP8, MMP14, MMP13, RHO
8hydroxamate4410.6TIMP4, MMP13, MMP14, MMP8, MMP12
91,10-phenanthroline44 211.5TIMP4, TIMP3, MMP14
10p0024410.5MET, MMP13, MMP14, MMP8, MMP7
11glycosaminoglycan4410.5TIMP3, FMOD, MET, MMP13, MMP8, ACTC1
12fibrinogen4410.5MMP13, MMP14, MMP8, MMP12, MMP7
1312-o-tetradecanoylphorbol 13-acetate4410.5MMP10, MMP14, MMP13, MET, TIMP3
14ribonucleic acid4410.5TIMP3, MET, MMP13, MMP14, MMP7, ACTC1
15serine4410.5VIP, NF2, MMP13, MMP14, MMP10, MMP8
16genistein44 28 59 2 11 2415.4TIMP3, MET, MMP13, MMP14, MMP8, MMP12
17uk 3833675910.4MMP13, MMP14, MMP10, MMP8, MMP12, MMP20
18gi 254023x5910.4MMP8, MMP12, MMP20, MMP27, MMP7, MMP10
19ag 14784410.4MET, MMP14, MMP7
20gm 60015910.4MMP13, MMP14, MMP10, MMP8, MMP12, MMP20
21dexamethasone44 49 28 1113.4VIP, TIMP3, MMP13, MMP14, MMP12
22marimastat44 59 1112.4MMP7, MMP27, MMP13, MMP14, MMP10, MMP8
23paraffin4410.4TIMP3, MET, NF2, MMP13, MMP14, MMP7
24matrigel4410.4TIMP3, MET, MMP13, MMP14, MMP10, MMP12
25proline4410.4FMOD, MET, RHO, MMP8, MMP20
26chondroitin sulfate44 2411.4MMP13, FMOD, TIMP3
27progesterone44 59 28 11 2414.4TIMP3, MET, NF2, MMP14, MMP8, MMP7
28oligonucleotide4410.4TIMP3, MET, MMP13, MMP14, MMP10, MMP8
29batimastat44 59 1112.4MMP13, MMP14, MMP10, MMP8, MMP12, MMP20
30hocl4410.4MMP7, MMP8
31retinoic acid44 2411.3TIMP3, MET, RHO, MMP13, MMP8, MMP7
32oxygen44 2411.3TIMP3, MET, MMP13, MMP14, MMP8, MMP12
33phosphatidylinositol4410.3TIMP3, MET, MMP13, MMP14, MMP12, MMP7
34cysteine4410.3VIP, TIMP3, MET, RHO, NF2, MMP13
35nitric oxide44 11 2412.3VIP, MET, MMP13, MMP8, MMP12, MMP7
36vegf4410.2VIP, TIMP3, MET, RHO, MMP13, MMP14
37glucose4410.2TIMP3, MET, MMP8, MMP7, ACTC1
38pd 98,0594410.2MMP14, MMP13, MET, TIMP3
39tyrosine4410.2VIP, TIMP3, FMOD, MET, NF2, MMP13
40ly2940024410.1TIMP3, MET, RHO, MMP14
41calcium44 49 11 2413.1VIP, TIMP3, MET, MMP13, MMP14, MMP10
42piperidine4410.1MMP13, RHO

GO Terms for genes affiliated with Refractive Error

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16Gene Ontology
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Cellular components related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.0FMOD, MMP13, MMP10, MMP8, MMP20, MMP7
2proteinaceous extracellular matrixGO:0055789.9MMP7, FMOD, MMP13, MMP10, MMP8, MMP12
3extracellular regionGO:0055769.6VIP, TIMP4, FMOD, MET, MMP13, MMP10

Biological processes related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagen catabolic processGO:03057410.0MMP7, MMP13, MMP14, MMP10, MMP8, MMP12
2proteolysisGO:00650810.0MMP14, MMP10, MMP8, MMP12, MMP20, MMP27
3extracellular matrix disassemblyGO:02261710.0MMP13, MMP14, MMP10, MMP8, MMP12, MMP20
4extracellular matrix organizationGO:0301989.7FMOD, MMP13, MMP14, MMP10, MMP8, MMP12

Molecular functions related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase inhibitor activityGO:00819110.3TIMP3, TIMP4
2metalloendopeptidase activityGO:00422210.0MMP7, MMP13, MMP14, MMP10, MMP8, MMP12
3calcium ion bindingGO:00550910.0MMP13, MMP14, MMP10, MMP8, MMP12, MMP20
4zinc ion bindingGO:0082709.7MMP13, MMP14, MMP10, MMP8, MMP12, MMP20

Products for genes affiliated with Refractive Error

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Refractive Error

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet