MCID: RFR003
MIFTS: 48

Refractive Error malady

Eye diseases category

Summaries for Refractive Error

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 The cornea and lens of your eye helps you focus. refractive errors are vision problems that happen when the shape of the eye keeps you from focusing well. the cause could be the length of the eyeball (longer or shorter), changes in the shape of the cornea, or aging of the lens. four common refractive errors are myopia, or nearsightedness - clear vision close up but blurry in the distance hyperopia, or farsightedness - clear vision in the distance but blurry close up presbyopia - inability to focus close up as a result of aging astigmatism - focus problems caused by the cornea the most common symptom is blurred vision. other symptoms may include double vision, haziness, glare or halos around bright lights, squinting, headaches, or eye strain. glasses or contact lenses can usually correct refractive errors. laser eye surgery may also be a possibility. nih: national eye institute

MalaCards: Refractive Error, also known as refractive errors, is related to myopia and strabismus. An important gene associated with Refractive Error is PRSS56 (protease, serine, 56), and among its related pathways are Vitamin A and carotenoid metabolism and Chemical carcinogenesis. The compounds n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:66 A refractive error, or refraction error, is an error in the focusing of light by the eye and a frequent... more...

Aliases & Classifications for Refractive Error

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9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

refractive error 9 11
refractive errors 46 35 63
eye refraction disorder 9
disorder of refraction 9


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Disease Ontology9 DOID:9835
MeSH36 D012030
NCIt41 C87145
ICD1026 H52.6

Related Diseases for Refractive Error

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Refractive Error:



Diseases related to refractive error

Symptoms for Refractive Error

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Drugs & Therapeutics for Refractive Error

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Refractive Error

Genetic Tests for Refractive Error

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Anatomical Context for Refractive Error

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34MalaCards
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MalaCards organs/tissues related to Refractive Error:

34
Eye, Testes, Endothelial, Retina

Animal Models for Refractive Error or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Refractive Error:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9RDH5, GJD2, SIX6, PRSS56
2MP:00053888.2CHRNG, MMP10, MMP12, KCNJ2
3MP:00053908.1CYP26A1, KCNJ2, BMP3, ZIC2
4MP:00036317.8CYP26A1, GJD2, SIX6, ZIC2, PRSS56, CHRNG
5MP:00053857.7CYP26A1, KCNJ2, MMP12, MMP10, ZIC2

Publications for Refractive Error

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53PubMed
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Articles related to Refractive Error:

(show top 50)    (show all 527)
idTitleAuthorsYear
1
Psychometric properties of the national eye institute refractive error correction quality-of-life questionnaire among Iranian patients. (23772124)
2013
2
Prevalence of vision impairment and refractive error in school children in Ba Ria - Yung Tau province, Vietnam. (24299145)
2013
3
An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. (22509102)
2012
4
Crystalline lens power and refractive error. (22199240)
2012
5
Blindness and visual impairment due to uncorrected refractive error in sub-Saharan Africa: review of recent population-based studies. (22317912)
2012
6
Different refractive errors in triplets with retinopathy of prematurity treated with bevacizumab. (22881829)
2012
7
Nature and nurture: the complex genetics of myopia and refractive error. (21155761)
2011
8
Calculating the error in refractive error. (21779015)
2011
9
Corrective lens use and refractive error among United States Air Force aircrew. (20358711)
2010
10
Refractive error in central India: the Central India Eye and Medical Study. (20045569)
2010
11
Sampling and measurement methods for a study of childhood refractive error in a UK population. (20558427)
2010
12
Success rates of retinal buckling surgery: relationship to refractive error and lens status: results from a large German case series. (20207006)
2010
13
Prevalence and associations of refractive error in indigenous Australians within central Australia: the Central Australian Ocular Health Study. (20491802)
2010
14
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
15
Uncorrected refractive errors, presbyopia and spectacle coverage: results from a rapid assessment of refractive error survey. (19874105)
2009
16
The hepatocyte growth factor receptor (MET) gene is not associated with refractive error and ocular biometrics in a Caucasian population. (20011629)
2009
17
Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36. (19626131)
2009
18
Prevalence of uncorrected refractive error and other eye problems among urban and rural school children. (20142964)
2009
19
Individual variations in human cone photoreceptor packing density: variations with refractive error. (18552378)
2008
20
Useful resources: refractive error. (17971918)
2007
21
Necessity of cycloplegia for assessing refractive error in 12-year-old children: a population-based study. (17659966)
2007
22
Overestimation of uncorrected refractive error in Singapore teenagers. (17510488)
2007
23
Relations between age, weight, refractive error and eye shape by computerized tomography in children. (17804923)
2007
24
Implantation of verisyse phakic intraocular lens to correct myopic refractive error after penetrating keratoplasty in pseudophakic eyes. (16331051)
2006
25
Uncorrected refractive error in Singapore teenagers. (16424534)
2006
26
Effect of postoperative refractive error on visual acuity and patient satisfaction after implantation of the Array multifocal intraocular lens. (16338567)
2005
27
Refractive error and visual impairment in school-age children in Gombak District, Malaysia. (15808262)
2005
28
The correlations between Central Corneal Thickness and age, gender, intraocular pressure and refractive error of aged 12-60 years old in rural Thai community. (16858956)
2005
29
Laser in situ keratomileusis for refractive error after cataract surgery. (15975465)
2005
30
Long-term changes in visual acuity and refractive error in amblyopes. (15252350)
2004
31
Recovery of refractive error after corneal refractive therapy. (15499264)
2004
32
Myopia and models and mechanisms of refractive error control. (12064076)
2002
33
Refractive error in children in a rural population in India. (11867575)
2002
34
Axial length and refractive error in X-linked retinoschisis. (11384589)
2001
35
Refractive Error Study in Children: sampling and measurement methods for a multi-country survey. (10764848)
2000
36
Refractive error changes in mixed astigmatism. (10768025)
1999
37
Tonic accommodation, age, and refractive error in children. (10235538)
1999
38
Pulsatile ocular blood flow variations with axial length and refractive error. (9286800)
1997
39
Change in postoperative refractive error when vitrectomy is added to intraocular lens implantation. (9368168)
1997
40
Effects of refractive error on detection acuity and resolution acuity in peripheral vision. (9331277)
1997
41
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
42
Relation between spherical refractive error and visual acuity. (1923335)
1991
43
Snellen acuity, refractive error, and the Scheerer phenomenon. (2082237)
1990
44
Effects of intraocular lens position errors on postoperative refractive error. (2355315)
1990
45
A comparison of cycloplegic refraction to the near retinoscopy technique for refractive error determination. (2212460)
1990
46
The influence of refractive error and lattice degeneration on the incidence of retinal detachment. (2562517)
1989
47
The accommodative response, refractive error and mental effort: 1. The sympathetic nervous system. (3203603)
1988
48
Visual acuity improvement following fading and feedback training--II. Relationship to changes in refractive error. (3240229)
1988
49
Refractive error changes in law students. (3631215)
1987
50
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985

Variations for Refractive Error

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Expression for genes affiliated with Refractive Error

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Refractive Error

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Pathways for genes affiliated with Refractive Error

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 61Thomson Reuters, 52PharmGKB, 13EMD Millipore, 54QIAGEN
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Compounds for genes affiliated with Refractive Error

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46Novoseek, 12DrugBank, 62Tocris Bioscience
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Compounds related to Refractive Error according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid46 1210.6MMP12, MMP10
2uk 383367629.6MMP12, MMP10
3gi 254023x629.5MMP12, MMP10
4batimastat46 62 1211.5MMP12, MMP10
5gm 6001629.4MMP12, MMP10
6marimastat46 62 1211.2MMP12, MMP10

GO Terms for genes affiliated with Refractive Error

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17Gene Ontology
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Biological processes related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.5MMP10, MMP12
2proteolysisGO:0065089.2PRSS56, MMP12, MMP10
3collagen catabolic processGO:0305749.2MMP10, MMP12
4visual perceptionGO:0076019.1GJD2, ZIC2, SIX6, RDH5
5synaptic transmissionGO:0072688.9KCNJ2, CHRNG, GJD2

Molecular functions related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.5MMP10, MMP12

Products for genes affiliated with Refractive Error

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Refractive Error

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet