MCID: RFR003
MIFTS: 40

Refractive Error malady

Eye diseases category

Summaries for Refractive Error

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MedlinePlus:32 The cornea and lens of your eye helps you focus. refractive errors are vision problems that happen when the shape of the eye keeps you from focusing well. the cause could be the length of the eyeball (longer or shorter), changes in the shape of the cornea, or aging of the lens. four common refractive errors are myopia, or nearsightedness - clear vision close up but blurry in the distance hyperopia, or farsightedness - clear vision in the distance but blurry close up presbyopia - inability to focus close up as a result of aging astigmatism - focus problems caused by the cornea the most common symptom is blurred vision. other symptoms may include double vision, haziness, glare or halos around bright lights, squinting, headaches, or eye strain. glasses or contact lenses can usually correct refractive errors. laser eye surgery may also be a possibility. nih: national eye institute

MalaCards based summary: Refractive Error, also known as refractive errors, is related to myopia and strabismus. An important gene associated with Refractive Error is PRSS56 (protease, serine, 56), and among its related pathways are Vitamin A and carotenoid metabolism and Chemical carcinogenesis. The compounds n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:63 A refractive error, or refraction error, is an error in the focusing of light by the eye and a frequent... more...

Aliases & Classifications for Refractive Error

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Refractive Error, Aliases & Descriptions:

Name: Refractive Error 9 11
Refractive Errors 43 32 60
 
Eye Refraction Disorder 9
Disorder of Refraction 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:9835
MeSH33 D012030
NCIt38 C87145
ICD1025 H52.6

Related Diseases for Refractive Error

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Graphical network of the top 20 diseases related to Refractive Error:



Diseases related to refractive error

Symptoms for Refractive Error

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Drugs & Therapeutics for Refractive Error

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Drug clinical trials:

Search ClinicalTrials for Refractive Error

Search NIH Clinical Center for Refractive Error

Genetic Tests for Refractive Error

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Anatomical Context for Refractive Error

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MalaCards organs/tissues related to Refractive Error:

31
Eye, Testes, Endothelial, Retina

Animal Models for Refractive Error or affiliated genes

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MGI Mouse Phenotypes related to Refractive Error:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9PRSS56, SIX6, GJD2, RDH5
2MP:00053888.2KCNJ2, MMP12, MMP10, CHRNG
3MP:00053908.1ZIC2, BMP3, KCNJ2, CYP26A1
4MP:00036317.8GJD2, SIX6, ZIC2, PRSS56, CHRNG, MMP12
5MP:00053857.7CYP26A1, KCNJ2, MMP12, MMP10, ZIC2

Publications for Refractive Error

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Articles related to Refractive Error:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Using femtosecond laser to create customized corneal flaps for patients with low and moderate refractive error differing in corneal thickness. (25807232)
2015
2
Screening for significant refractive error using a combination of distance visual acuity and near visual acuity. (25689600)
2015
3
Refractive error, binocular vision and accommodation of children with Down syndrome. (25395109)
2014
4
Effect of myopic refractive error on the glaucoma diagnostic ability of cirrus high-definition optical coherence tomography. (25175669)
2014
5
Toward eliminating blindness due to uncorrected refractive errors: assessment of refractive services in the northern and central regions of Ghana. (25331076)
2014
6
Generational difference of refractive error and risk factors in the Handan Offspring Myopia Study. (25097244)
2014
7
Psychometric properties of the national eye institute refractive error correction quality-of-life questionnaire among Iranian patients. (23772124)
2013
8
Prevalence of vision impairment and refractive error in school children in Ba Ria - Yung Tau province, Vietnam. (24299145)
2013
9
An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. (22509102)
2012
10
Crystalline lens power and refractive error. (22199240)
2012
11
Blindness and visual impairment due to uncorrected refractive error in sub-Saharan Africa: review of recent population-based studies. (22317912)
2012
12
Different refractive errors in triplets with retinopathy of prematurity treated with bevacizumab. (22881829)
2012
13
Nature and nurture: the complex genetics of myopia and refractive error. (21155761)
2011
14
Calculating the error in refractive error. (21779015)
2011
15
Corrective lens use and refractive error among United States Air Force aircrew. (20358711)
2010
16
Refractive error in central India: the Central India Eye and Medical Study. (20045569)
2010
17
Sampling and measurement methods for a study of childhood refractive error in a UK population. (20558427)
2010
18
Success rates of retinal buckling surgery: relationship to refractive error and lens status: results from a large German case series. (20207006)
2010
19
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
20
Uncorrected refractive errors, presbyopia and spectacle coverage: results from a rapid assessment of refractive error survey. (19874105)
2009
21
The hepatocyte growth factor receptor (MET) gene is not associated with refractive error and ocular biometrics in a Caucasian population. (20011629)
2009
22
Individual variations in human cone photoreceptor packing density: variations with refractive error. (18552378)
2008
23
Useful resources: refractive error. (17971918)
2007
24
Necessity of cycloplegia for assessing refractive error in 12-year-old children: a population-based study. (17659966)
2007
25
Overestimation of uncorrected refractive error in Singapore teenagers. (17510488)
2007
26
Relations between age, weight, refractive error and eye shape by computerized tomography in children. (17804923)
2007
27
Implantation of verisyse phakic intraocular lens to correct myopic refractive error after penetrating keratoplasty in pseudophakic eyes. (16331051)
2006
28
Uncorrected refractive error in Singapore teenagers. (16424534)
2006
29
Effect of postoperative refractive error on visual acuity and patient satisfaction after implantation of the Array multifocal intraocular lens. (16338567)
2005
30
Refractive error and visual impairment in school-age children in Gombak District, Malaysia. (15808262)
2005
31
The correlations between Central Corneal Thickness and age, gender, intraocular pressure and refractive error of aged 12-60 years old in rural Thai community. (16858956)
2005
32
Laser in situ keratomileusis for refractive error after cataract surgery. (15975465)
2005
33
Long-term changes in visual acuity and refractive error in amblyopes. (15252350)
2004
34
Recovery of refractive error after corneal refractive therapy. (15499264)
2004
35
Myopia and models and mechanisms of refractive error control. (12064076)
2002
36
Axial length and refractive error in X-linked retinoschisis. (11384589)
2001
37
Refractive Error Study in Children: sampling and measurement methods for a multi-country survey. (10764848)
2000
38
Refractive error changes in mixed astigmatism. (10768025)
1999
39
Tonic accommodation, age, and refractive error in children. (10235538)
1999
40
Pulsatile ocular blood flow variations with axial length and refractive error. (9286800)
1997
41
Change in postoperative refractive error when vitrectomy is added to intraocular lens implantation. (9368168)
1997
42
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
43
Relation between spherical refractive error and visual acuity. (1923335)
1991
44
Snellen acuity, refractive error, and the Scheerer phenomenon. (2082237)
1990
45
Effects of intraocular lens position errors on postoperative refractive error. (2355315)
1990
46
A comparison of cycloplegic refraction to the near retinoscopy technique for refractive error determination. (2212460)
1990
47
The influence of refractive error and lattice degeneration on the incidence of retinal detachment. (2562517)
1989
48
The accommodative response, refractive error and mental effort: 1. The sympathetic nervous system. (3203603)
1988
49
Refractive error changes in law students. (3631215)
1987
50
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985

Variations for Refractive Error

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Expression for genes affiliated with Refractive Error

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Search GEO for disease gene expression data for Refractive Error.

Pathways for genes affiliated with Refractive Error

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Compounds for genes affiliated with Refractive Error

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Compounds related to Refractive Error according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid43 1210.6MMP10, MMP12
2uk 383367599.6MMP12, MMP10
3gi 254023x599.5MMP12, MMP10
4batimastat43 59 1211.5MMP10, MMP12
5gm 6001599.4MMP12, MMP10
6marimastat43 59 1211.2MMP10, MMP12

GO Terms for genes affiliated with Refractive Error

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Biological processes related to Refractive Error according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:00226179.5MMP10, MMP12
2proteolysisGO:00065089.2PRSS56, MMP10, MMP12
3collagen catabolic processGO:00305749.2MMP10, MMP12
4visual perceptionGO:00076019.1RDH5, GJD2, SIX6, ZIC2
5synaptic transmissionGO:00072688.9KCNJ2, CHRNG, GJD2

Molecular functions related to Refractive Error according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00042229.5MMP10, MMP12

Products for genes affiliated with Refractive Error

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  • Antibodies
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  • Proteins
  • Kits and Assays

Sources for Refractive Error

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet