MCID: RFR003
MIFTS: 48

Refractive Error malady

Eye diseases category
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Summaries for Refractive Error

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MedlinePlus:33 The cornea and lens of your eye helps you focus. refractive errors are vision problems that happen when the shape of the eye keeps you from focusing well. the cause could be the length of the eyeball (longer or shorter), changes in the shape of the cornea, or aging of the lens. four common refractive errors are myopia, or nearsightedness - clear vision close up but blurry in the distance hyperopia, or farsightedness - clear vision in the distance but blurry close up presbyopia - inability to focus close up as a result of aging astigmatism - focus problems caused by the cornea the most common symptom is blurred vision. other symptoms may include double vision, haziness, glare or halos around bright lights, squinting, headaches, or eye strain. glasses or contact lenses can usually correct refractive errors. laser eye surgery may also be a possibility. nih: national eye institute

MalaCards based summary: Refractive Error, also known as refractive errors, is related to myopia and strabismus. An important gene associated with Refractive Error is PRSS56 (protease, serine, 56), and among its related pathways are Vitamin A and carotenoid metabolism and Chemical carcinogenesis. The compounds n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid and uk 383367 have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and endothelial, and related mouse phenotypes are vision/eye and respiratory system.

Wikipedia:65 A refractive error, or refraction error, is an error in the focusing of light by the eye and a frequent... more...

Aliases & Classifications for Refractive Error

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Refractive Error, Aliases & Descriptions:

Name: Refractive Error 8 10
Refractive Errors 44 33 62
 
Eye Refraction Disorder 8 62
Disorder of Refraction 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:9835
MeSH34 D012030
NCIt39 C87145
ICD1025 H52.6

Related Diseases for Refractive Error

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Graphical network of the top 20 diseases related to Refractive Error:



Diseases related to refractive error

Symptoms for Refractive Error

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Drugs & Therapeutics for Refractive Error

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Drug clinical trials:

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Genetic Tests for Refractive Error

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Anatomical Context for Refractive Error

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MalaCards organs/tissues related to Refractive Error:

32
Eye, Testes, Endothelial, Retina

Animal Models for Refractive Error or affiliated genes

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MGI Mouse Phenotypes related to Refractive Error:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.9PRSS56, SIX6, GJD2, RDH5
2MP:00053888.2KCNJ2, MMP12, MMP10, CHRNG
3MP:00053908.1ZIC2, BMP3, KCNJ2, CYP26A1
4MP:00036317.8GJD2, SIX6, ZIC2, PRSS56, CHRNG, MMP12
5MP:00053857.7CYP26A1, KCNJ2, MMP12, MMP10, ZIC2

Publications for Refractive Error

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Articles related to Refractive Error:

(show top 50)    (show all 560)
idTitleAuthorsYear
1
Refractive error, binocular vision and accommodation of children with Down syndrome. (25395109)
2014
2
Effect of myopic refractive error on the glaucoma diagnostic ability of cirrus high-definition optical coherence tomography. (25175669)
2014
3
Toward eliminating blindness due to uncorrected refractive errors: assessment of refractive services in the northern and central regions of Ghana. (25331076)
2014
4
Generational difference of refractive error and risk factors in the Handan Offspring Myopia Study. (25097244)
2014
5
Psychometric properties of the national eye institute refractive error correction quality-of-life questionnaire among Iranian patients. (23772124)
2013
6
Prevalence of vision impairment and refractive error in school children in Ba Ria - Yung Tau province, Vietnam. (24299145)
2013
7
An international collaborative family-based whole genome quantitative trait linkage scan for myopic refractive error. (22509102)
2012
8
Crystalline lens power and refractive error. (22199240)
2012
9
Blindness and visual impairment due to uncorrected refractive error in sub-Saharan Africa: review of recent population-based studies. (22317912)
2012
10
Different refractive errors in triplets with retinopathy of prematurity treated with bevacizumab. (22881829)
2012
11
Nature and nurture: the complex genetics of myopia and refractive error. (21155761)
2011
12
Calculating the error in refractive error. (21779015)
2011
13
Corrective lens use and refractive error among United States Air Force aircrew. (20358711)
2010
14
Refractive error in central India: the Central India Eye and Medical Study. (20045569)
2010
15
Sampling and measurement methods for a study of childhood refractive error in a UK population. (20558427)
2010
16
Success rates of retinal buckling surgery: relationship to refractive error and lens status: results from a large German case series. (20207006)
2010
17
Trachoma, cataracts and uncorrected refractive error are still important contributors to visual morbidity in two remote indigenous communities of the Northern Territory, Australia. (19702703)
2009
18
Uncorrected refractive errors, presbyopia and spectacle coverage: results from a rapid assessment of refractive error survey. (19874105)
2009
19
The hepatocyte growth factor receptor (MET) gene is not associated with refractive error and ocular biometrics in a Caucasian population. (20011629)
2009
20
Individual variations in human cone photoreceptor packing density: variations with refractive error. (18552378)
2008
21
Useful resources: refractive error. (17971918)
2007
22
Necessity of cycloplegia for assessing refractive error in 12-year-old children: a population-based study. (17659966)
2007
23
Overestimation of uncorrected refractive error in Singapore teenagers. (17510488)
2007
24
Relations between age, weight, refractive error and eye shape by computerized tomography in children. (17804923)
2007
25
Implantation of verisyse phakic intraocular lens to correct myopic refractive error after penetrating keratoplasty in pseudophakic eyes. (16331051)
2006
26
Uncorrected refractive error in Singapore teenagers. (16424534)
2006
27
Effect of postoperative refractive error on visual acuity and patient satisfaction after implantation of the Array multifocal intraocular lens. (16338567)
2005
28
Refractive error and visual impairment in school-age children in Gombak District, Malaysia. (15808262)
2005
29
The correlations between Central Corneal Thickness and age, gender, intraocular pressure and refractive error of aged 12-60 years old in rural Thai community. (16858956)
2005
30
Laser in situ keratomileusis for refractive error after cataract surgery. (15975465)
2005
31
Long-term changes in visual acuity and refractive error in amblyopes. (15252350)
2004
32
Recovery of refractive error after corneal refractive therapy. (15499264)
2004
33
Myopia and models and mechanisms of refractive error control. (12064076)
2002
34
Refractive error in children in a rural population in India. (11867575)
2002
35
Axial length and refractive error in X-linked retinoschisis. (11384589)
2001
36
Refractive Error Study in Children: sampling and measurement methods for a multi-country survey. (10764848)
2000
37
Refractive error changes in mixed astigmatism. (10768025)
1999
38
Tonic accommodation, age, and refractive error in children. (10235538)
1999
39
Pulsatile ocular blood flow variations with axial length and refractive error. (9286800)
1997
40
Change in postoperative refractive error when vitrectomy is added to intraocular lens implantation. (9368168)
1997
41
Refractive error and ocular motility in plagiocephaly. (7923229)
1994
42
Relation between spherical refractive error and visual acuity. (1923335)
1991
43
Snellen acuity, refractive error, and the Scheerer phenomenon. (2082237)
1990
44
Effects of intraocular lens position errors on postoperative refractive error. (2355315)
1990
45
A comparison of cycloplegic refraction to the near retinoscopy technique for refractive error determination. (2212460)
1990
46
The influence of refractive error and lattice degeneration on the incidence of retinal detachment. (2562517)
1989
47
The accommodative response, refractive error and mental effort: 1. The sympathetic nervous system. (3203603)
1988
48
Visual acuity improvement following fading and feedback training--II. Relationship to changes in refractive error. (3240229)
1988
49
Refractive error changes in law students. (3631215)
1987
50
Visual acuity, refractive error, and astigmatism following corneal transplantation for pseudophakic bullous keratopathy. (3909036)
1985

Variations for Refractive Error

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Expression for genes affiliated with Refractive Error

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Expression patterns in normal tissues for genes affiliated with Refractive Error

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Pathways for genes affiliated with Refractive Error

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Compounds for genes affiliated with Refractive Error

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Compounds related to Refractive Error according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1110.6MMP10, MMP12
2uk 383367619.6MMP12, MMP10
3gi 254023x619.5MMP12, MMP10
4batimastat44 61 1111.5MMP10, MMP12
5gm 6001619.4MMP12, MMP10
6marimastat44 61 1111.2MMP10, MMP12

GO Terms for genes affiliated with Refractive Error

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Biological processes related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix disassemblyGO:0226179.5MMP10, MMP12
2proteolysisGO:0065089.2PRSS56, MMP10, MMP12
3collagen catabolic processGO:0305749.2MMP10, MMP12
4visual perceptionGO:0076019.1RDH5, GJD2, SIX6, ZIC2
5synaptic transmissionGO:0072688.9KCNJ2, CHRNG, GJD2

Molecular functions related to Refractive Error according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:0042229.5MMP10, MMP12

Products for genes affiliated with Refractive Error

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  • Antibodies
  • Proteins
  • Lysates

Sources for Refractive Error

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet