MCID: RGL001
MIFTS: 25

Regular Astigmatism malady

Categories: Eye diseases

Aliases & Classifications for Regular Astigmatism

Aliases & Descriptions for Regular Astigmatism:

Name: Regular Astigmatism 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11781
ICD10 33 H52.22
ICD9CM 35 367.21
SNOMED-CT 64 68905002
UMLS 69 C0152193

Summaries for Regular Astigmatism

MalaCards based summary : Regular Astigmatism is related to astigmatism and vulvovaginal candidiasis. An important gene associated with Regular Astigmatism is CER1 (Cerberus 1, DAN Family BMP Antagonist). Affiliated tissues include eye and endothelial, and related phenotypes are Decreased viability and growth/size/body region

Related Diseases for Regular Astigmatism

Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 astigmatism 10.2
2 vulvovaginal candidiasis 10.1 CDKN2A FLNA
3 prolymphocytic leukemia 10.0 CYLC1 DPT
4 barbiturate dependence 9.9 CDKN2A FLNA
5 cataract 9.8
6 keratoconus 9.8
7 refractive error 9.8
8 endotheliitis 9.8
9 chronic congestive splenomegaly 9.8 CER1 DPT FLNA LCK SOST
10 splenic sequestration 8.2 ASPH CDKN2A CER1 CYLC1 CYLD DPT

Graphical network of the top 20 diseases related to Regular Astigmatism:



Diseases related to Regular Astigmatism

Symptoms & Phenotypes for Regular Astigmatism

GenomeRNAi Phenotypes related to Regular Astigmatism according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.44 CDKN2A CYLD LCK MATK
2 Decreased viability GR00221-A-2 9.44 CYLD LCK
3 Decreased viability GR00221-A-3 9.44 CDKN2A LCK
4 Decreased viability GR00221-A-4 9.44 CDKN2A
5 Decreased viability GR00301-A 9.44 CYLD LCK
6 Decreased viability GR00342-S-1 9.44 LCK
7 Decreased viability GR00342-S-3 9.44 LCK

MGI Mouse Phenotypes related to Regular Astigmatism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.81 ASPH CDKN2A CER1 CYLD DPT FLNA
2 limbs/digits/tail MP:0005371 9.35 ASPH CER1 CYLD SOST ZEB1
3 normal MP:0002873 9.1 CER1 CYLD FLNA MATK NBL1 SOST

Drugs & Therapeutics for Regular Astigmatism

Interventional clinical trials:


id Name Status NCT ID Phase
1 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
2 Observational Study of Keratoconus and Post-keratoplasty Eyes Unknown status NCT02109848
3 Limbal Relaxing Incision Versus Toric Intraocular Lens for Corneal Astigmatism During Cataract Surgery. Unknown status NCT02067429
4 A Trial of Toric Versus Non-toric Intraocular Lenses in Phacoemulsification Cataract Surgery Unknown status NCT01712503
5 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
6 Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus Completed NCT02617368
7 ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL) Completed NCT00967473
8 Visual Outcomes of Topography Guided Photorefractive Keratectomy (PRK) for Treatment of Patients With Irregular Cornea Recruiting NCT03140046
9 Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconus Recruiting NCT02857881
10 Measurement Repeatability in Contemporary Aberrometry Not yet recruiting NCT02687022

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

Anatomical Context for Regular Astigmatism

MalaCards organs/tissues related to Regular Astigmatism:

39
Eye, Endothelial

Publications for Regular Astigmatism

Articles related to Regular Astigmatism:

id Title Authors Year
1
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. ( 27660920 )
2016
2
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. ( 25954510 )
2015
3
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. ( 26435831 )
2015
4
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. ( 25116780 )
2014
5
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. ( 22296843 )
2012
6
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. ( 10615439 )
1999

Variations for Regular Astigmatism

Expression for Regular Astigmatism

Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for Regular Astigmatism

GO Terms for Regular Astigmatism

Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.8 CYLD LCK MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine autophosphorylation GO:0038083 9.37 LCK MATK
2 negative regulation of cell proliferation GO:0008285 9.35 ASPH CDKN2A CER1 DPT ZEB1
3 positive regulation of T cell receptor signaling pathway GO:0050862 9.32 CYLD LCK
4 determination of dorsal identity GO:0048263 9.26 CER1 NBL1
5 sequestering of BMP in extracellular matrix GO:0035582 9.16 CER1 NBL1
6 negative regulation of BMP signaling pathway GO:0030514 8.8 CER1 NBL1 SOST

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.46 CDKN2A FLNA SOST ZEB1
2 BMP binding GO:0036122 8.96 CER1 NBL1
3 morphogen activity GO:0016015 8.62 CER1 NBL1

Sources for Regular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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