MCID: RGL001
MIFTS: 27

Regular Astigmatism

Categories: Eye diseases

Aliases & Classifications for Regular Astigmatism

MalaCards integrated aliases for Regular Astigmatism:

Name: Regular Astigmatism 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11781
ICD10 32 H52.22
ICD9CM 34 367.21
SNOMED-CT 64 68905002
UMLS 69 C0152193

Summaries for Regular Astigmatism

MalaCards based summary : Regular Astigmatism is related to astigmatism and preretinal fibrosis. An important gene associated with Regular Astigmatism is INSRR (Insulin Receptor Related Receptor), and among its related pathways/superpathways is Tyrosine Kinases / Adaptors. Affiliated tissues include eye and endothelial, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Related Diseases for Regular Astigmatism

Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 astigmatism 30.3 DPT FLNA NBL1
2 preretinal fibrosis 10.1 DPT LCK
3 cataract 9.9
4 keratoconus 9.9
5 refractive error 9.9
6 endotheliitis 9.9
7 ametropic amblyopia 9.7 CYLC1 DPT

Graphical network of the top 20 diseases related to Regular Astigmatism:



Diseases related to Regular Astigmatism

Symptoms & Phenotypes for Regular Astigmatism

GenomeRNAi Phenotypes related to Regular Astigmatism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.5 MATK
2 Decreased substrate adherent cell growth GR00193-A-2 9.5 JAK2 LCK MATK
3 Decreased substrate adherent cell growth GR00193-A-3 9.5 JAK2 LCK
4 Decreased substrate adherent cell growth GR00193-A-4 9.5 LCK
5 Decreased viability GR00221-A-1 9.4 CYLD INSRR LCK MATK
6 Decreased viability GR00221-A-2 9.4 CYLD LCK
7 Decreased viability GR00221-A-3 9.4 LCK
8 Decreased viability GR00301-A 9.4 CYLD INSRR LCK
9 Decreased viability GR00342-S-1 9.4 LCK
10 Decreased viability GR00342-S-3 9.4 LCK

MGI Mouse Phenotypes related to Regular Astigmatism:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ASPH CER1 CYLD DPT FLNA JAK2
2 normal MP:0002873 9.28 CER1 CYLD FLNA INSRR JAK2 MATK

Drugs & Therapeutics for Regular Astigmatism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observational Study of Keratoconus and Post-keratoplasty Eyes Unknown status NCT02109848
2 Measurement Repeatability in Contemporary Aberrometry Unknown status NCT02687022
3 Study of Clinical Performance of Corneal Topography Measurement Using an Optical Biometer Completed NCT01861925
4 Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus Completed NCT02617368
5 Manually Performed Limbal Relaxing Incisions vs Femtosecond Laser-guided Astigmatic Keratotomy Not yet recruiting NCT03264534

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

Anatomical Context for Regular Astigmatism

MalaCards organs/tissues related to Regular Astigmatism:

38
Eye, Endothelial

Publications for Regular Astigmatism

Articles related to Regular Astigmatism:

# Title Authors Year
1
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. ( 27660920 )
2016
2
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. ( 26435831 )
2015
3
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. ( 25954510 )
2015
4
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. ( 25116780 )
2014
5
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. ( 22296843 )
2012
6
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. ( 10615439 )
1999

Variations for Regular Astigmatism

Expression for Regular Astigmatism

Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for Regular Astigmatism

Pathways related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 JAK2 LCK MATK

GO Terms for Regular Astigmatism

Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic component of cytoplasmic side of plasma membrane GO:0031234 8.92 CYLD JAK2 LCK MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.77 ASPH CER1 DPT JAK2 ZEB1
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.61 INSRR LCK MATK
3 negative regulation of BMP signaling pathway GO:0030514 9.43 CER1 NBL1 SOST
4 positive regulation of T cell receptor signaling pathway GO:0050862 9.4 CYLD LCK
5 peptidyl-tyrosine autophosphorylation GO:0038083 9.33 JAK2 LCK MATK
6 determination of dorsal identity GO:0048263 9.32 CER1 NBL1
7 peptidyl-tyrosine phosphorylation GO:0018108 9.26 INSRR JAK2 LCK MATK
8 sequestering of BMP in extracellular matrix GO:0035582 8.62 CER1 NBL1

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SH2 domain binding GO:0042169 9.4 JAK2 LCK
2 insulin receptor substrate binding GO:0043560 9.37 INSRR JAK2
3 non-membrane spanning protein tyrosine kinase activity GO:0004715 9.33 JAK2 LCK MATK
4 BMP binding GO:0036122 9.32 CER1 NBL1
5 morphogen activity GO:0016015 9.26 CER1 NBL1
6 protein tyrosine kinase activity GO:0004713 9.26 INSRR JAK2 LCK MATK
7 phosphatidylinositol 3-kinase binding GO:0043548 8.8 INSRR JAK2 LCK

Sources for Regular Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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