MCID: RGL001
MIFTS: 21

Regular Astigmatism malady

Eye diseases category

Aliases & Classifications for Regular Astigmatism

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Aliases & Descriptions for Regular Astigmatism:

Name: Regular Astigmatism 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:11781
SNOMED-CT59 68905002
ICD9CM29 367.21

Summaries for Regular Astigmatism

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MalaCards based summary: Regular Astigmatism is related to astigmatism and cataract. An important gene associated with Regular Astigmatism is CER1 (Cerberus 1, DAN Family BMP Antagonist), and among its related pathways are HTLV-I infection and . Affiliated tissues include eye and endothelial.

Related Diseases for Regular Astigmatism

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Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1astigmatism10.5
2cataract10.2
3keratoconus10.2
4refractive error10.2
5endotheliitis10.2
6melanotic neuroectodermal tumor10.1LCK, ZEB1
7posterior mediastinum cancer9.9CYLC1, DPT
8apocrine adenosis of breast9.8DPT, LCK, MATK
9acquired hemangioma9.8DPT, NBL1
10mixed lacrimal gland cancer8.3ASPH, CDKN2A, CER1, CYLC1, CYLD, DPT

Graphical network of diseases related to Regular Astigmatism:



Diseases related to regular astigmatism

Symptoms for Regular Astigmatism

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Drugs & Therapeutics for Regular Astigmatism

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Interventional clinical trials:

idNameStatusNCT IDPhase
1SUPRACOR for Myopia and Myopic AstigmatismActive, not recruitingNCT01404884Phase 3
2Study of Clinical Performance of Corneal Topography Measurement Using an Optical BiometerCompletedNCT01861925
3Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste KeratoconusCompletedNCT02617368
4ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)CompletedNCT00967473
5Observational Study of Keratoconus and Post-keratoplasty EyesRecruitingNCT02109848
6Limbal Relaxing Incision Versus Toric Intraocular Lens for Corneal Astigmatism During Cataract Surgery.RecruitingNCT02067429
7Measurement Repeatability in Contemporary AberrometryNot yet recruitingNCT02687022
8A Trial of Toric Versus Non-toric Intraocular Lenses in Phacoemulsification Cataract SurgeryNot yet recruitingNCT01712503

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

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Anatomical Context for Regular Astigmatism

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MalaCards organs/tissues related to Regular Astigmatism:

33
Eye, Endothelial

Animal Models for Regular Astigmatism or affiliated genes

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MGI Mouse Phenotypes related to Regular Astigmatism:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Regular Astigmatism

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Articles related to Regular Astigmatism:

idTitleAuthorsYear
1
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. (26435831)
2015
2
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. (25954510)
2015
3
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. (25116780)
2014
4
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. (22296843)
2012
5
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. (10615439)
1999

Variations for Regular Astigmatism

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Expression for genes affiliated with Regular Astigmatism

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Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for genes affiliated with Regular Astigmatism

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Pathways related to Regular Astigmatism according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3CDKN2A, HLA-G, LCK
2
TGF-beta Signaling Pathway (sino)
Show member pathways
9.1CDKN2A, HLA-G, LCK

GO Terms for genes affiliated with Regular Astigmatism

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Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:00312349.3CYLD, LCK, MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1pattern specification processGO:000738910.2ASPH, ZEB1
2sequestering of BMP in extracellular matrixGO:003558210.2CER1, NBL1
3regulation of protein stabilityGO:003164710.1ASPH, CDKN2A
4determination of dorsal identityGO:004826310.0CER1, NBL1
5negative regulation of BMP signaling pathwayGO:00305149.9CER1, NBL1
6peptidyl-tyrosine autophosphorylationGO:00380839.3LCK, MATK
7negative regulation of cell proliferationGO:00082858.7ASPH, CDKN2A, CER1, DPT, ZEB1

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1morphogen activityGO:00160159.9CER1, NBL1
2non-membrane spanning protein tyrosine kinase activityGO:00047159.6LCK, MATK
3BMP bindingGO:00361229.3CER1, NBL1

Sources for Regular Astigmatism

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet