MCID: RGL001
MIFTS: 26

Regular Astigmatism malady

Category: Eye diseases

Aliases & Classifications for Regular Astigmatism

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Aliases & Descriptions for Regular Astigmatism:

Name: Regular Astigmatism 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:11781
ICD1030 H52.22
SNOMED-CT62 68905002
ICD9CM32 367.21

Summaries for Regular Astigmatism

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MalaCards based summary: Regular Astigmatism is related to astigmatism and maxillary sinusitis. An important gene associated with Regular Astigmatism is CER1 (Cerberus 1, DAN Family BMP Antagonist), and among its related pathways Affiliated tissues include eye and endothelial, and related mouse phenotypes are Decreased viability and limbs/digits/tail.

Related Diseases for Regular Astigmatism

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Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1astigmatism10.2
2maxillary sinusitis10.2FLNA, SOST
3ankylosis10.1CDKN2A, FLNA
4malignant histiocytic disease10.0CDKN2A, FLNA
5amyotrophic neuralgia9.9CYLC1, DPT
6cataract9.8
7keratoconus9.8
8refractive error9.8
9endotheliitis9.8
10connective tissue cancer9.6DPT, LCK, MATK
11ametropic amblyopia9.5DPT, NBL1
12necrosis of ear ossicle6.1ASPH, CDKN2A, CER1, CYLC1, CYLD, DPT

Graphical network of diseases related to Regular Astigmatism:



Diseases related to regular astigmatism

Symptoms & Phenotypes for Regular Astigmatism

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GenomeRNAi Phenotypes related to Regular Astigmatism according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00381-A-19.8CDKN2A, CYLD, LCK, MATK

MGI Mouse Phenotypes related to Regular Astigmatism according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053719.7ASPH, CER1, CYLD, SOST, ZEB1
2MP:00028738.9CER1, CYLD, FLNA, MATK, NBL1, SOST
3MP:00053788.5ASPH, CDKN2A, CER1, CYLD, DPT, FLNA
4MP:00053908.2CDKN2A, CER1, FLNA, NBL1, SOST, ZEB1

Drugs & Therapeutics for Regular Astigmatism

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Interventional clinical trials:

idNameStatusNCT IDPhase
1SUPRACOR for Myopia and Myopic AstigmatismActive, not recruitingNCT01404884Phase 3
2Limbal Relaxing Incision Versus Toric Intraocular Lens for Corneal Astigmatism During Cataract Surgery.Unknown statusNCT02067429
3A Trial of Toric Versus Non-toric Intraocular Lenses in Phacoemulsification Cataract SurgeryUnknown statusNCT01712503
4Study of Clinical Performance of Corneal Topography Measurement Using an Optical BiometerCompletedNCT01861925
5Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste KeratoconusCompletedNCT02617368
6ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)CompletedNCT00967473
7Observational Study of Keratoconus and Post-keratoplasty EyesRecruitingNCT02109848
8Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive KeratoconusRecruitingNCT02857881
9Measurement Repeatability in Contemporary AberrometryNot yet recruitingNCT02687022

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

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Anatomical Context for Regular Astigmatism

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MalaCards organs/tissues related to Regular Astigmatism:

36
Eye, Endothelial

Publications for Regular Astigmatism

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Articles related to Regular Astigmatism:

idTitleAuthorsYear
1
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. (27660920)
2016
2
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. (25954510)
2015
3
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. (26435831)
2015
4
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. (25116780)
2014
5
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. (22296843)
2012
6
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. (10615439)
1999

Variations for Regular Astigmatism

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Expression for genes affiliated with Regular Astigmatism

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Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for genes affiliated with Regular Astigmatism

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Pathways related to Regular Astigmatism according to GeneCards Suite gene sharing:

   (show less)
idSuper pathwaysTop Affiliating Genes

GO Terms for genes affiliated with Regular Astigmatism

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Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:00312349.4CYLD, LCK, MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1determination of dorsal identityGO:004826310.3CER1, NBL1
2negative regulation of BMP signaling pathwayGO:00305149.9CER1, NBL1, SOST
3peptidyl-tyrosine autophosphorylationGO:00380839.7LCK, MATK
4sequestering of BMP in extracellular matrixGO:00355829.6CER1, NBL1
5negative regulation of cell proliferationGO:00082859.1ASPH, CDKN2A, CER1, DPT, ZEB1

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BMP bindingGO:003612210.1CER1, NBL1
2morphogen activityGO:001601510.0CER1, NBL1
3non-membrane spanning protein tyrosine kinase activityGO:00047159.6LCK, MATK

Sources for Regular Astigmatism

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet