MCID: RGL001
MIFTS: 23

Regular Astigmatism malady

Category: Eye diseases

Aliases & Classifications for Regular Astigmatism

About this section

Aliases & Descriptions for Regular Astigmatism:

Name: Regular Astigmatism 11 13 66

Classifications:



External Ids:

Disease Ontology11 DOID:11781
ICD1028 H52.22
SNOMED-CT60 68905002
ICD9CM30 367.21

Summaries for Regular Astigmatism

About this section
MalaCards based summary: Regular Astigmatism is related to astigmatism and maxillary sinusitis. An important gene associated with Regular Astigmatism is CER1 (Cerberus 1, DAN Family BMP Antagonist), and among its related pathways is TGF-beta Signaling Pathway (sino). Affiliated tissues include eye and endothelial, and related mouse phenotypes are limbs/digits/tail and skeleton.

Related Diseases for Regular Astigmatism

About this section

Diseases related to Regular Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
idRelated DiseaseScoreTop Affiliating Genes
1astigmatism10.3
2maxillary sinusitis10.2FLNA, SOST
3ankylosis10.1CDKN2A, FLNA
4malignant histiocytic disease10.0CDKN2A, FLNA
5amyotrophic neuralgia9.9CYLC1, DPT
6cataract9.9
7keratoconus9.9
8refractive error9.9
9endotheliitis9.9
10ametropic amblyopia9.5DPT, NBL1
11connective tissue cancer9.5DPT, LCK, MATK
12necrosis of ear ossicle5.6ASPH, CDKN2A, CER1, CYLC1, CYLD, DPT

Graphical network of diseases related to Regular Astigmatism:



Diseases related to regular astigmatism

Symptoms for Regular Astigmatism

About this section

Drugs & Therapeutics for Regular Astigmatism

About this section

Interventional clinical trials:

idNameStatusNCT IDPhase
1SUPRACOR for Myopia and Myopic AstigmatismActive, not recruitingNCT01404884Phase 3
2Study of Clinical Performance of Corneal Topography Measurement Using an Optical BiometerCompletedNCT01861925
3Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste KeratoconusCompletedNCT02617368
4ACRYSOF® Toric NATURAL T9 Intraocular Lens (IOL)CompletedNCT00967473
5Observational Study of Keratoconus and Post-keratoplasty EyesRecruitingNCT02109848
6Limbal Relaxing Incision Versus Toric Intraocular Lens for Corneal Astigmatism During Cataract Surgery.RecruitingNCT02067429
7Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive KeratoconusRecruitingNCT02857881
8Measurement Repeatability in Contemporary AberrometryNot yet recruitingNCT02687022
9A Trial of Toric Versus Non-toric Intraocular Lenses in Phacoemulsification Cataract SurgeryNot yet recruitingNCT01712503

Search NIH Clinical Center for Regular Astigmatism

Genetic Tests for Regular Astigmatism

About this section

Anatomical Context for Regular Astigmatism

About this section

MalaCards organs/tissues related to Regular Astigmatism:

34
Eye, Endothelial

Animal Models for Regular Astigmatism or affiliated genes

About this section

MGI Mouse Phenotypes related to Regular Astigmatism:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.7ASPH, CER1, CYLD, SOST, ZEB1
2MP:00053908.3CDKN2A, CER1, FLNA, NBL1, SOST, ZEB1
3MP:00028738.2CER1, CYLD, FLNA, MATK, NBL1, SOST
4MP:00053787.6ASPH, CDKN2A, CER1, CYLD, DPT, FLNA

Publications for Regular Astigmatism

About this section

Articles related to Regular Astigmatism:

idTitleAuthorsYear
1
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. (27660920)
2016
2
Comparison of two different scheimpflug devices in the detection of keratoconus, regular astigmatism, and healthy corneas. (25954510)
2015
3
Evaluation of the orientation of the steepest meridian of regular astigmatism among highly myopic Egyptian patients seeking non-ablative surgical correction of the refractive error. (26435831)
2015
4
Combined special capsular tension ring and toric IOL implantation for management of post-DALK high regular astigmatism with subluxated traumatic cataract. (25116780)
2014
5
Combined Descemet-stripping automated endothelial keratoplasty and phacoemulsification with toric intraocular lens implantation for treatment of failed penetrating keratoplasty with high regular astigmatism. (22296843)
2012
6
Bivariate analysis of surgically induced regular astigmatism. Mathematical analysis and graphical display. (10615439)
1999

Variations for Regular Astigmatism

About this section

Expression for genes affiliated with Regular Astigmatism

About this section
Search GEO for disease gene expression data for Regular Astigmatism.

Pathways for genes affiliated with Regular Astigmatism

About this section

Pathways related to Regular Astigmatism according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
8.8CER1, DPT, NBL1, SOST

GO Terms for genes affiliated with Regular Astigmatism

About this section

Cellular components related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extrinsic component of cytoplasmic side of plasma membraneGO:00312349.2CYLD, LCK, MATK

Biological processes related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1determination of dorsal identityGO:004826310.2CER1, NBL1
2sequestering of BMP in extracellular matrixGO:003558210.1CER1, NBL1
3peptidyl-tyrosine autophosphorylationGO:00380839.8LCK, MATK
4negative regulation of BMP signaling pathwayGO:00305149.6CER1, NBL1, SOST
5negative regulation of cell proliferationGO:00082858.6ASPH, CDKN2A, CER1, DPT, ZEB1

Molecular functions related to Regular Astigmatism according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1BMP bindingGO:00361229.7CER1, NBL1
2morphogen activityGO:00160159.7CER1, NBL1
3non-membrane spanning protein tyrosine kinase activityGO:00047159.2LCK, MATK

Sources for Regular Astigmatism

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet