MCID: RLP003
MIFTS: 40

Relapsing Fever malady

Infectious category

Summaries for Relapsing Fever

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Relapsing fever is bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea. It is caused by certain species of Borrelia spirochetes. There are two types of relapsing fever:

MalaCards: Relapsing Fever, also known as relapsing fever, unspecified, is related to tick-borne relapsing fever and lyme disease. An important gene associated with Relapsing Fever is MVK (mevalonate kinase). The compounds mevalonate and colchicine have been mentioned in the context of this disorder. Related mouse phenotype hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in borrelia, which is transmitted by tick or transmitted by body louse.

Wikipedia:64 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

Aliases & Classifications for Relapsing Fever

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
relapsing fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

relapsing fever 8 10 45 49 61
relapsing fever, unspecified 8
relapsing fever nos 8


External Ids:

Disease Ontology8 DOID:13034
ICD9CM27 087, 087.9
MeSH35 D012061
MESH via Orphanet36 D012061
ICD10 via Orphanet26 A68
SNOMED-CT via Orphanet58 420079008
UMLS via Orphanet62 C0035021
ICD1025 A68, A68.9

Related Diseases for Relapsing Fever

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 48)
idRelated DiseaseScoreTop Affiliating Genes
1tick-borne relapsing fever31.4PURB, PURA, ELK3
2lyme disease30.8CXCL13, CFH, CFHR1, ELK3
3louse-borne relapsing fever10.9
4typhus10.4
5q fever10.3
6spirochetes disease10.3
7trench fever10.3
8relapsing epidemic typhus10.2
9leptospirosis10.1
10meningoencephalitis10.1
11sodoku disease10.1
12colorado tick fever10.1
13tick infestation10.1
14atypical hemolytic-uremic syndrome10.0CFH
15hyper-igd syndrome10.0MVK
16palindromic rheumatism10.0MEFV
17retinal drusen10.0CFH
18glomerulonephritis10.0CFH
19familial cold autoinflammatory syndrome10.0MEFV, TNFRSF1A
20blau syndrome10.0MEFV, MVK
21tumor necrosis factor receptor-associated periodic syndrome10.0MEFV, TNFRSF1A, MVK
22chronic infantile neurological cutaneous articular syndrome10.0MVK, TNFRSF1A, MEFV
23muckle-wells syndrome10.0MEFV, TNFRSF1A
24age related macular degeneration10.0CFHR1, CFH
25familial mediterranean fever10.0MEFV, TNFRSF1A, MVK
26pediculus humanus corporis infestation10.0
27severe acute respiratory syndrome10.0
28radiculopathy10.0
29glanders10.0
30chagas disease10.0
31splenic abscess10.0
32protein s deficiency10.0
33babesiosis10.0
34typhoid fever10.0
35brain disease10.0
36spotted fever10.0
37syphilis10.0
38thrombocytopenia10.0
39thrombophlebitis10.0
40tic disorder10.0
41toxoplasmosis10.0
42trypanosomiasis10.0
43uveitis10.0
44vasculitis10.0
45protein r deficiency10.0
46headache10.0
47nephritis10.0
48arthritis10.0MEFV, TNFRSF1A, MVK

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to relapsing fever

Clinical Features for Relapsing Fever

Drugs & Therapeutics for Relapsing Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Relapsing Fever

Drug clinical trials:

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Search NIH Clinical Center for Relapsing Fever

Search CenterWatch for Relapsing Fever

Genetic Tests for Relapsing Fever

Anatomical Context for Relapsing Fever

Animal Models for Relapsing Fever or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Relapsing Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CFH, CXCL13, NTRK1, MEFV, ARSI, GAB2

Publications for Relapsing Fever

Sources:
51PubMed
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Articles related to Relapsing Fever:

(show top 50)    (show all 480)
idTitleAuthorsYear
1
Genome Sequence of the Relapsing Fever Borreliosis Species Borrelia hispanica. (24435869)
2014
2
First isolation of the relapsing fever spirochete, Borrelia hermsii, from a domestic dog. (24252262)
2013
3
Tickborne relapsing fever caused by Borrelia persica, Uzbekistan and Tajikistan. (21762608)
2011
4
Relapsing uveitis and optic neuritis due to chronic Q fever. (20733024)
2011
5
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. (20382883)
2010
6
A novel surface antigen of relapsing fever spirochetes can discriminate between relapsing fever and Lyme borreliosis. (20147497)
2010
7
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
8
Borrelia hispanica relapsing fever, Morocco. (19861058)
2009
9
Tick-borne relapsing fever in a new highland endemic focus of western Iran. (19695158)
2009
10
Identification of conserved antigens for early serodiagnosis of relapsing fever Borrelia. (19443544)
2009
11
Relapsing fever borreliosis in interleukin-10-deficient mice. (18794280)
2008
12
Acute respiratory distress syndrome in persons with tickborne relapsing fever--three states, 2004-2005. (17947965)
2007
13
Relapsing fever in a traveller from Senegal: determination of Borrelia species using molecular methods. (16455121)
2006
14
Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils. (16629672)
2006
15
Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis. (17054065)
2006
16
Identifying relapsing fever Borrelia, Senegal. (15757570)
2005
17
Tick-borne relapsing fever during pregnancy: a case report. (16363764)
2005
18
Cross-species hybridization of a Borrelia burgdorferi DNA array reveals infection- and culture-associated genes of the unsequenced genome of the relapsing fever agent Borrelia hermsii. (14731275)
2004
19
Vector interactions and molecular adaptations of lyme disease and relapsing fever spirochetes associated with transmission by ticks. (11897061)
2002
20
The epidemiology of tick-borne relapsing fever in the United States. (12224586)
2002
21
Tick-borne relapsing fever caused by Borrelia turicatae. (12237608)
2002
22
The relapsing fever spirochete Borrelia hermsii contains multiple, antigen-encoding circular plasmids that are homologous to the cp32 plasmids of Lyme disease spirochetes. (10858201)
2000
23
A focus of tick-borne relapsing fever in southern Zaire. (9243047)
1997
24
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
25
Hydrochlorothiazide-induced relapsing fever. (1286960)
1992
26
Outbreak of relapsing fever--Grand Canyon National Park, Arizona, 1990. (1902280)
1991
27
The variable antigens Vmp7 and Vmp21 of the relapsing fever bacterium Borrelia hermsii are structurally analogous to the VSG proteins of the African trypanosome. (1706456)
1990
28
Common source outbreak of relapsing fever--California. (2117241)
1990
29
Louse-borne relapsing fever: I. A clinical and laboratory study of 363 cases in the Sudan. (871032)
1977
30
Tropical thrombophlebitis. The role of relapsing fever in its causation. (1198239)
1975
31
Experimental louse-borne relapsing fever in the grivet monkey, Cercopithecus aethiops. III. Crisis following therapy. (4217572)
1974
32
Lipid catabolism of relapsing fever borreliae. (4361292)
1974
33
Bleeding in louse-borne relapsing fever. I. Clinical studies in 37 patients. (5157439)
1971
34
Susceptibility of Various Species of Rodents to the Relapsing Fever Spirochete, Borrelia hermsii. (16557828)
1970
35
Separation of relapsing fever spirochaetes from blood by DEAE cellulose anion exchanger. (5500541)
1970
36
Tick-borne relapsing fever in Kashmir: mice inoculation--a diagnostic method of choice. (4964791)
1967
37
Infections of Ornithodoros ticks with relapsing fever spirochaetes, and the mechanisms of their transmission. (13303098)
1956
38
Focus of relapsing fever transmitted by lice in Ethiopia]. (13284980)
1955
39
Treatment of relapsing fever with antibiotics. (13139204)
1952
40
Tick-borne relapsing fever on the Witwatersrand gold mines; its treatment with aureomycin. (15442582)
1950
41
Prevention of tick-borne relapsing fever. (15411885)
1950
42
Relapsing fever with hemorrhage into the skin, spleen, peritoneal cavity, and wall of bowel and congestion of the pia-arachnoid]. (20239131)
1947
43
Weil-Felix and typhus complement-fixation tests in relapsing fever, with special reference to B. proteus OX-K agglutination. (21018821)
1946
44
Penicillin therapy in relapsing fever. (20996632)
1946
45
Relapsing fever with nephritis and subarachnoid haemorrhage. (21003842)
1945
46
The effect of low temperature on the spirochetes of relapsing fever. (21005566)
1945
47
Effect of Intracranial Penicillin Therapy on Brain Involvement in Experimental Relapsing Fever. (16560924)
1945
48
OCULAR COMPLICATIONS IN RELAPSING FEVER. (18169904)
1943
49
Relapsing Fever: A New Etiological Observation: With Case Report of a Field Worker. (18742514)
1933
50
THE PART PLAYED BY PEDICULUS CORPORIS IN THE TRANSMISSION OF RELAPSING FEVER. (20763589)
1907

Genetic Variations for Relapsing Fever

Expression for genes affiliated with Relapsing Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Relapsing Fever

Search GEO for disease gene expression data for Relapsing Fever.

Pathways for genes affiliated with Relapsing Fever

Compounds for genes affiliated with Relapsing Fever

Sources:
45Novoseek, 60Tocris Bioscience, 2BitterDB, 29IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Relapsing Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mevalonate459.9MEFV, TNFRSF1A, MVK
2colchicine60 45 2 29 1113.6NTRK1, MEFV, TNFRSF1A
3phenylalanine459.5MVK, TNFRSF1A, CPA1, NTRK1
4zinc45 249.6FHL1, TNFRSF1A, NTRK1, REST, CFH, CPA1
5tyrosine458.3TNFRSF1A, GAB2, MEFV, NTRK1, REST, CFH

GO Terms for genes affiliated with Relapsing Fever

Sources:
16Gene Ontology
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Cellular components related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:0056629.9PURA, PURB

Biological processes related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:0507289.8MEFV, MVK, TNFRSF1A
2cellular response to electrical stimulusGO:0712579.1ADSS, REST
3negative regulation of transcription, DNA-dependentGO:0458928.0ELK3, CCDC85B, PURB, PURA, REST

Molecular functions related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1purine-rich negative regulatory element bindingGO:0324229.8ELK3, PURA

Products for genes affiliated with Relapsing Fever

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  • Lysates
  • Antibodies

Sources for Relapsing Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet