MCID: RLP003
MIFTS: 49

Relapsing Fever malady

Infectious diseases category

Summaries for Relapsing Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Relapsing fever is bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea. It is caused by certain species of Borrelia spirochetes. There are two types of relapsing fever:

MalaCards: Relapsing Fever, also known as relapsing fever, unspecified, is related to tick-borne relapsing fever and lyme disease. An important gene associated with Relapsing Fever is MVK (mevalonate kinase). The compounds mevalonate and colchicine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related mouse phenotype hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in borrelia, which is transmitted by tick or transmitted by body louse.

Wikipedia:63 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

Aliases & Classifications for Relapsing Fever

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8Disease Ontology, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
relapsing fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

relapsing fever 8 10 44 48 60
relapsing fever, unspecified 8
relapsing fever nos 8


External Ids:

Disease Ontology8 DOID:13034
ICD9CM27 087, 087.9
MeSH34 D012061
MESH via Orphanet35 D012061
ICD10 via Orphanet26 A68.0, A68.1, A68.9
SNOMED-CT via Orphanet57 420079008
UMLS via Orphanet61 C0035021
ICD1025 A68, A68.9

Related Diseases for Relapsing Fever

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17GeneCards, 18GeneDecks
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Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 55)
idRelated DiseaseScoreTop Affiliating Genes
1tick-borne relapsing fever31.4PURB, PURA, ELK3
2lyme disease30.8CXCL13, CFH, CFHR1, ELK3
3louse-borne relapsing fever10.9
4malaria10.4
5typhus10.4
6trench fever10.2
7epidemic typhus10.2
8leptospirosis10.1
9meningoencephalitis10.1
10sodoku disease10.1
11peritonitis10.1
12plague10.1
13tick infestation10.1
14atypical hemolytic-uremic syndrome10.0CFH
15hyper-igd syndrome10.0MVK
16palindromic rheumatism10.0MEFV
17retinal drusen10.0CFH
18glomerulonephritis10.0CFH
19familial cold autoinflammatory syndrome10.0MEFV, TNFRSF1A
20blau syndrome10.0MEFV, MVK
21tumor necrosis factor receptor-associated periodic syndrome10.0MEFV, TNFRSF1A, MVK
22chronic infantile neurological cutaneous articular syndrome10.0MVK, TNFRSF1A, MEFV
23muckle-wells syndrome10.0MEFV, TNFRSF1A
24age related macular degeneration10.0CFHR1, CFH
25familial mediterranean fever10.0MEFV, TNFRSF1A, MVK
26arthritis10.0MEFV, TNFRSF1A, MVK
27pediculus humanus corporis infestation9.9
28severe acute respiratory syndrome9.9
29radiculopathy9.9
30glanders9.9
31chagas disease9.9
32arachnoiditis9.9
33splenic abscess9.9
34babesiosis9.9
35typhoid fever9.9
36colorado tick fever9.9
37brain disease9.9
38ehrlichiosis9.9
39leishmaniasis9.9
40liver disease9.9
41multiple sclerosis9.9
42myocarditis9.9
43neuropathy9.9
44pneumonia9.9
45poliomyelitis9.9
46spotted fever9.9
47syphilis9.9
48thrombocytopenia9.9
49thrombophlebitis9.9
50thyroiditis9.9

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to relapsing fever

Clinical Features for Relapsing Fever

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Drugs & Therapeutics for Relapsing Fever

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Relapsing Fever

Search CenterWatch for Relapsing Fever

Genetic Tests for Relapsing Fever

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Anatomical Context for Relapsing Fever

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32MalaCards
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MalaCards organs/tissues related to Relapsing Fever:

32
Brain, Testes, Spleen, Heart, B cells, Salivary gland, Skin, Thyroid, Liver, Kidney, Endothelial

Animal Models for Relapsing Fever or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Relapsing Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.2CFH, CXCL13, NTRK1, MEFV, ARSI, GAB2

Publications for Relapsing Fever

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50PubMed
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Articles related to Relapsing Fever:

(show top 50)    (show all 492)
idTitleAuthorsYear
1
Genome Sequence of the Relapsing Fever Borreliosis Species Borrelia hispanica. (24435869)
2014
2
First isolation of the relapsing fever spirochete, Borrelia hermsii, from a domestic dog. (24252262)
2013
3
Novel relapsing fever Borrelia detected in African penguins (Spheniscus demersus) admitted to two rehabilitation centers in South Africa. (21870246)
2012
4
Tick-borne relapsing fever in a new highland endemic focus of western Iran. (19695158)
2009
5
Identification of conserved antigens for early serodiagnosis of relapsing fever Borrelia. (19443544)
2009
6
Complement factor H binding by different Lyme disease and relapsing fever Borrelia in animals and human. (19604355)
2009
7
The genome of Borrelia recurrentis, the agent of deadly louse-borne relapsing fever, is a degraded subset of tick-borne Borrelia duttonii. (18787695)
2008
8
High production of CXCL13 in blood and brain during persistent infection with the relapsing fever spirochete Borrelia turicatae. (17356382)
2007
9
Dr Osler's relapsing fever. (16804156)
2006
10
Possibilities for relapsing fever reemergence. (16704771)
2006
11
Relapsing fever in a traveller from Senegal: determination of Borrelia species using molecular methods. (16455121)
2006
12
Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils. (16629672)
2006
13
Complications of pregnancy and transplacental transmission of relapsing-fever borreliosis. (17054065)
2006
14
Information from your family doctor. Tick-borne relapsing fever: what you should know. (16342835)
2005
15
Tick-borne relapsing fever. (16342834)
2005
16
Identifying relapsing fever Borrelia, Senegal. (15757570)
2005
17
Relapsing fever spirochetes contain chromosomal genes with unique direct tandemly repeated sequences. (15845510)
2005
18
Forgotten diseases: relapsing fever. (15881316)
2004
19
Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a northern spotted owl. (11838214)
2002
20
Relapsing fever in Gondar, Ethiopia. (12380884)
2002
21
Tick-borne relapsing fever caused by Borrelia turicatae. (12237608)
2002
22
Equine abortion associated with the Borrelia parkeri-B. turicatae tick-borne relapsing fever spirochete group. (11923397)
2002
23
Tick-borne relapsing fever in the northwestern United States and southwestern Canada. (9455520)
1998
24
Tick-borne relapsing fever in British Columbia, Canada: first isolation of Borrelia hermsii. (9817862)
1998
25
Population structure of the relapsing fever spirochete Borrelia hermsii as indicated by polymorphism of two multigene families that encode immunogenic outer surface lipoproteins. (9453591)
1998
26
Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial. (7784810)
1995
27
Relapsing fever in Saudi Arabia: Report of two cases. (17587930)
1995
28
Late relapse of tick-borne relapsing fever following treatment with doxycycline. (8434483)
1993
29
Experimental infection of the mouse brain by a relapsing fever Borrelia species: a molecular analysis. (8515101)
1993
30
Epidemic of louse-borne relapsing fever in Ethiopia. (7901534)
1993
31
Lyme disease acquired in Israel: report of a case and studies of serological cross reactivity in relapsing fever. (8407274)
1993
32
Relapsing fever in the US Virgin Islands: a previously unrecognized focus of infection. (2037807)
1991
33
Molecular biology of antigenic variation in Lyme borreliosis and relapsing fever: a comparative analysis. (1947817)
1991
34
Outbreak of relapsing fever--Grand Canyon National Park, Arizona, 1990. (1902280)
1991
35
Congenital tick-borne relapsing fever: report of a case with first documentation of transplacental transmission. (7126796)
1982
36
Relapsing Fever revisited. (18748834)
1981
37
Louse-borne relapsing fever: II. Combined penicillin and tetracycline therapy in 160 Sudanese patients. (871033)
1977
38
Relapsing fever, 1973, in Grand Canyon National Park. (4827140)
1974
39
Leucopenia and fever in the "Jarisch-Herxheimer" reaction of louse-borne relapsing fever. (4169111)
1968
40
Studies on Ornithodorus moubata Murray (Argasidae) in East Africa. I. Observations on distribution, food and climatic requirements in relation to relapsing fever as evidence of biological variation. (13524140)
1958
41
Observations on the epidemiology of relapsing fever in Kashmir. (14937746)
1951
42
Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. (18138841)
1949
43
Activation of latent kala-azar by malaria and relapsing fever. (18891450)
1948
44
Relapsing fever in Cyprus. (18110345)
1948
45
Epidemiological Study on Relapsing Fever in North Africa (1943-1945). (20603922)
1948
46
Tick-borne Relapsing Fever. (20786348)
1945
47
Relapsing Fever: Comments on Its Incidence in Nevada. (18744208)
1937
48
Relapsing Fever. (18743245)
1935
49
The Serbian Epidemics of Typhus and Relapsing Fever in 1915: Their Origin, Course, and Preventive Measures employed for their Arrest : (An A8tiological and Preventive Study based on Records of British Military Sanitary Mission to Serbia, 1915.). (20905688)
1920
50
Rash in Relapsing Fever. (20745845)
1870

Genetic Variations for Relapsing Fever

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Expression for genes affiliated with Relapsing Fever

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Relapsing Fever

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Pathways for genes affiliated with Relapsing Fever

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Compounds for genes affiliated with Relapsing Fever

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44Novoseek, 59Tocris Bioscience, 2BitterDB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Relapsing Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1mevalonate449.9MEFV, TNFRSF1A, MVK
2colchicine59 44 2 28 1113.6NTRK1, MEFV, TNFRSF1A
3phenylalanine449.5MVK, TNFRSF1A, NTRK1, CPA1
4zinc44 249.6CPA1, TNFRSF1A, FHL1, NTRK1, REST, CFH
5tyrosine448.3GAB2, MEFV, NTRK1, REST, CFH, CPA1

GO Terms for genes affiliated with Relapsing Fever

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16Gene Ontology
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Cellular components related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:0056629.9PURA, PURB

Biological processes related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:0507289.8MEFV, TNFRSF1A, MVK
2cellular response to electrical stimulusGO:0712579.1ADSS, REST
3negative regulation of transcription, DNA-dependentGO:0458928.0CCDC85B, PURB, PURA, REST, ELK3

Molecular functions related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1purine-rich negative regulatory element bindingGO:0324229.8ELK3, PURA

Products for genes affiliated with Relapsing Fever

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Relapsing Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet