MCID: RLP003
MIFTS: 42

Relapsing Fever malady

Infectious diseases, Rare diseases categories

Summaries for Relapsing Fever

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Disease Ontology:9 A primary bacterial infectious disease that results in infection, has material basis in borrelia, which is transmitted by tick or transmitted by body louse.

MalaCards based summary: Relapsing Fever is related to tick-borne relapsing fever and lyme disease. An important gene associated with Relapsing Fever is PURA (purine-rich element binding protein A). The compounds dutp and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Wikipedia:63 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

Aliases & Classifications for Relapsing Fever

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 3CDC, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Relapsing Fever, Aliases & Descriptions:

Name: Relapsing Fever 9 11 43 47 3 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

47
relapsing fever:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

Disease Ontology9 DOID:13034
MeSH33 D012061
ICD9CM27 087, 087.9
Orphanet47 91547
MESH via Orphanet34 D012061
ICD10 via Orphanet26 A68.0, A68.1, A68.9
UMLS via Orphanet61 C0035021
ICD1025 A68

Related Diseases for Relapsing Fever

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Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to relapsing fever

Symptoms for Relapsing Fever

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Drugs & Therapeutics for Relapsing Fever

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Drug clinical trials:

Search ClinicalTrials for Relapsing Fever

Search NIH Clinical Center for Relapsing Fever

Genetic Tests for Relapsing Fever

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Anatomical Context for Relapsing Fever

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MalaCards organs/tissues related to Relapsing Fever:

31
Brain, Testes, Spleen, Heart, Neutrophil, Salivary gland, Kidney, Liver, Thyroid, Skin, B cells, Endothelial

Animal Models for Relapsing Fever or affiliated genes

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MGI Mouse Phenotypes related to Relapsing Fever:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MEFV, ELK3, AKAP13, TNFRSF1A, CFH, PURA
2MP:00053978.0ARSI, PURA, CFH, TNFRSF1A, AKAP13, MEFV
3MP:00053877.8PURA, CFH, TNFRSF1A, AKAP13, ELK3, MEFV
4MP:00107687.6PURA, CFH, TNFRSF1A, AKAP13, ELK3, MEFV

Publications for Relapsing Fever

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Articles related to Relapsing Fever:

(show top 50)    (show all 491)
idTitleAuthorsYear
1
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. (25892254)
2015
2
The relapsing fever spirochete Borrelia miyamotoi is cultivable in a modified Kelly-Pettenkofer medium, and is resistant to human complement. (25189195)
2014
3
Trench fever: a relapsing fever occurring among the British troops in France and Salonica. (24845898)
2014
4
Inactivation of genes for antigenic variation in the relapsing fever spirochete Borrelia hermsii reduces infectivity in mice and transmission by ticks. (24699793)
2014
5
Tick-borne relapsing fever in pregnancy. (23939208)
2013
6
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. (23953389)
2013
7
Detection of relapsing fever spirochetes (Borrelia hermsii and Borrelia coriaceae) in free-ranging mule deer (Odocoileus hemionus) from Nevada, United States. (21995265)
2012
8
A novel relapsing fever Borrelia sp. infects the salivary glands of the molted hard tick, Amblyomma geoemydae. (22910061)
2012
9
Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. (21803390)
2011
10
Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. (22000350)
2011
11
Genetic transformation of the relapsing fever spirochete Borrelia hermsii: stable integration and expression of green fluorescent protein from linear plasmid 200. (21551306)
2011
12
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
13
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. (20382883)
2010
14
Phylogenetic analysis of a virulent Borrelia species isolated from patients with relapsing fever. (20463158)
2010
15
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
16
Characterization of a novel relapsing fever spirochete in the midgut, coxal fluid, and salivary glands of the bat tick Carios kelleyi. (19281412)
2009
17
Results of a 10-year survey of louse-borne relapsing fever in southern Ethiopia: a decline in endemicity. (18577339)
2008
18
Relapsing fever spirochetes retain infectivity after prolonged in vitro cultivation. (18637723)
2008
19
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
20
Dr Osler's relapsing fever. (16804156)
2006
21
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. (16815378)
2006
22
Vasculitis of the aortic arch and cardiac valves as the cause of relapsing fever of unknown origin in an elderly, white man. (16267601)
2006
23
Imported tickborne relapsing fever, France. (16422011)
2005
24
Typing of Borrelia relapsing fever group strains. (15498172)
2004
25
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. (12646649)
2003
26
Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a northern spotted owl. (11838214)
2002
27
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
28
Images in clinical medicine. Relapsing fever. (8815942)
1996
29
An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. (7778052)
1995
30
Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial. (7784810)
1995
31
Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody. (1572965)
1992
32
UTHSCSA scientists study relapsing fever. (1962294)
1991
33
Relapsing fever in the US Virgin Islands: a previously unrecognized focus of infection. (2037807)
1991
34
Lyme borreliosis: a relapsing fever-like disease? (1947807)
1991
35
Relapsing fever in Sichili. (6335941)
1984
36
Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever. (6132178)
1983
37
Bleeding in louse-borne relapsing fever. I. Clinical studies in 37 patients. (5157439)
1971
38
Tick-borne relapsing fever in Kashmir: mice inoculation--a diagnostic method of choice. (4964791)
1967
39
Experimental relapsing fever initiated by Borrelia hermsi. II. Sequential appearance of major serotypes in the rat. (5338694)
1967
40
International Sanitary Conventions and Regulations, plague and relapsing fever. (20604049)
1959
41
Antibiotic resistance of relapsing fever spirochetes. (13425439)
1956-1957
42
Infections of Ornithodoros ticks with relapsing fever spirochaetes, and the mechanisms of their transmission. (13303098)
1956
43
The effect of protein deficiency on the resistance of rats to infection with spirochetes of relapsing fever. (14832488)
1951
44
Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. (18138841)
1949
45
Activation of latent kala-azar by malaria and relapsing fever. (18891450)
1948
46
Sterile splenic abscess after relapsing fever. (18909674)
1948
47
Comparative effectiveness of penicillins G, F, K, and X in experimental relapsing fever. (20262378)
1947
48
Penicillin in the treatment of experimental relapsing fever in rats. (20998614)
1946
49
Relapsing fever. (21065367)
1945
50
Relapsing fever; report of a sporadic outbreak, including treatment with penicillin. (21003743)
1945

Variations for Relapsing Fever

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Expression for genes affiliated with Relapsing Fever

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Search GEO for disease gene expression data for Relapsing Fever.

Pathways for genes affiliated with Relapsing Fever

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Compounds for genes affiliated with Relapsing Fever

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Compounds related to Relapsing Fever according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1dutp439.8NTRK1, TNFRSF1A
2mevalonate439.8MVK, MEFV, TNFRSF1A
3c2ceramide439.8NTRK1, TNFRSF1A
4colchicine43 59 2 28 1213.7NTRK1, MEFV, TNFRSF1A
5phenylalanine439.6NTRK1, MVK, TNFRSF1A
6alanine439.2CFH, TNFRSF1A, MVK, NTRK1
7threonine439.2TNFRSF1A, AKAP13, MVK, NTRK1
8estradiol43 24 1211.0NTRK1, AKAP13, TNFRSF1A
9serine438.9CFH, TNFRSF1A, AKAP13, MVK, NTRK1
10atp43 289.7TNFRSF1A, ADSS, AKAP13, MVK, NTRK1
11tyrosine438.6CFH, TNFRSF1A, AKAP13, MEFV, NTRK1

GO Terms for genes affiliated with Relapsing Fever

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Cellular components related to Relapsing Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:00056629.4PURA, PURB
2nucleusGO:00056347.2CCDC85B, MEFV, ELK3, AKAP13, TNFRSF1A, PURA

Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:00507289.2MVK, MEFV, TNFRSF1A
2negative regulation of transcription, DNA-templatedGO:00458928.2CCDC85B, ELK3, PURA, PURB

Molecular functions related to Relapsing Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:00036979.7PURA, PURB
2purine-rich negative regulatory element bindingGO:00324229.6ELK3, PURA
3SMAD bindingGO:00463329.4PURA, PURB
4protein bindingGO:00055156.7PURA, CFH, TNFRSF1A, ADSS, AKAP13, ELK3

Products for genes affiliated with Relapsing Fever

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Sources for Relapsing Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet