MCID: RLP003
MIFTS: 53

Relapsing Fever malady

Infectious diseases, Rare diseases categories
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Summaries for Relapsing Fever

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8Disease Ontology, 4CDC, 65Wikipedia, 33MalaCards
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CDC:4 Relapsing fever is bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea. It is caused by certain species of Borrelia spirochetes. There are two types of relapsing fever:

MalaCards: Relapsing Fever, also known as relapsing fever, unspecified, is related to tick-borne relapsing fever and lyme disease. An important gene associated with Relapsing Fever is PURA (purine-rich element binding protein A). The compounds dutp and mevalonate have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology:8 A primary bacterial infectious disease that results in infection, has material basis in borrelia, which is transmitted by tick or transmitted by body louse.

Wikipedia:65 Relapsing fever is a vector-borne disease caused by infection with certain bacteria in the genus... more...

Aliases & Classifications for Relapsing Fever

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8Disease Ontology, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases, Rare diseases


Characteristics (Orphanet epidemiological data):

49
relapsing fever:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

relapsing fever 8 10 45 49 62
relapsing fever, unspecified 8
relapsing fever nos 8


External Ids:

Disease Ontology8 DOID:13034
MeSH35 D012061
ICD9CM27 087, 087.9
MESH via Orphanet36 D012061
ICD10 via Orphanet26 A68.0, A68.1, A68.9
SNOMED-CT via Orphanet59 420079008
UMLS via Orphanet63 C0035021
ICD1025 A68, A68.9

Related Diseases for Relapsing Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to relapsing fever

Symptoms for Relapsing Fever

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Drugs & Therapeutics for Relapsing Fever

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

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Genetic Tests for Relapsing Fever

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Anatomical Context for Relapsing Fever

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33MalaCards
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MalaCards organs/tissues related to Relapsing Fever:

33
Brain, Testes, Spleen, Heart, Salivary gland, B cells, Skin, Thyroid, Liver, Kidney, Endothelial

Animal Models for Relapsing Fever or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Relapsing Fever:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053768.2MEFV, ELK3, AKAP13, TNFRSF1A, CFH, PURA
2MP:00053978.0PURA, ARSI, NTRK1, MEFV, AKAP13, TNFRSF1A
3MP:00053877.8PURA, CFH, TNFRSF1A, AKAP13, ELK3, MEFV
4MP:00107687.6NTRK1, MEFV, ELK3, AKAP13, TNFRSF1A, CFH

Publications for Relapsing Fever

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52PubMed
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Articles related to Relapsing Fever:

(show top 50)    (show all 470)
idTitleAuthorsYear
1
Tick-borne relapsing fever in pregnancy. (23939208)
2013
2
A case of meningoencephalitis by the relapsing fever spirochaete Borrelia miyamotoi in Europe. (23953389)
2013
3
Detection of relapsing fever spirochetes (Borrelia hermsii and Borrelia coriaceae) in free-ranging mule deer (Odocoileus hemionus) from Nevada, United States. (21995265)
2012
4
A novel relapsing fever Borrelia sp. infects the salivary glands of the molted hard tick, Amblyomma geoemydae. (22910061)
2012
5
Comparison of antibiotic regimens for treating louse-borne relapsing fever: a meta-analysis. (21803390)
2011
6
Humans infected with relapsing fever spirochete Borrelia miyamotoi, Russia. (22000350)
2011
7
Genetic transformation of the relapsing fever spirochete Borrelia hermsii: stable integration and expression of green fluorescent protein from linear plasmid 200. (21551306)
2011
8
Concomitant infection decreases the malaria burden but escalates relapsing fever borreliosis. (20145098)
2010
9
Induction of distinct neurologic disease manifestations during relapsing fever requires T lymphocytes. (20382883)
2010
10
Phylogenetic analysis of a virulent Borrelia species isolated from patients with relapsing fever. (20463158)
2010
11
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. (19411042)
2009
12
Characterization of a novel relapsing fever spirochete in the midgut, coxal fluid, and salivary glands of the bat tick Carios kelleyi. (19281412)
2009
13
Results of a 10-year survey of louse-borne relapsing fever in southern Ethiopia: a decline in endemicity. (18577339)
2008
14
Relapsing fever spirochetes retain infectivity after prolonged in vitro cultivation. (18637723)
2008
15
Louse-borne relapsing fever and malaria co-infection in Ethiopia. (17540107)
2007
16
Dr Osler's relapsing fever. (16804156)
2006
17
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. (16815378)
2006
18
Vasculitis of the aortic arch and cardiac valves as the cause of relapsing fever of unknown origin in an elderly, white man. (16267601)
2006
19
Imported tickborne relapsing fever, France. (16422011)
2005
20
Typing of Borrelia relapsing fever group strains. (15498172)
2004
21
The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes. (12646649)
2003
22
Fatal spirochetosis due to a relapsing fever-like Borrelia sp. in a northern spotted owl. (11838214)
2002
23
Erythrocyte-aggregating relapsing fever spirochete Borrelia crocidurae induces formation of microemboli. (10558950)
1999
24
Uptake and killing of Lyme disease and relapsing fever borreliae in the perfused rat liver and by isolated Kupffer cells. (8613404)
1996
25
Images in clinical medicine. Relapsing fever. (8815942)
1996
26
An overview of tick-borne relapsing fever with emphasis on outbreaks in Texas. (7778052)
1995
27
Treatment of louse-borne relapsing fever with low dose penicillin or tetracycline: a clinical trial. (7784810)
1995
28
Identification of the tick-borne relapsing fever spirochete Borrelia hermsii by using a species-specific monoclonal antibody. (1572965)
1992
29
UTHSCSA scientists study relapsing fever. (1962294)
1991
30
Relapsing fever in the US Virgin Islands: a previously unrecognized focus of infection. (2037807)
1991
31
Lyme borreliosis: a relapsing fever-like disease? (1947807)
1991
32
Relapsing fever in Sichili. (6335941)
1984
33
Meptazinol diminishes the Jarisch-Herxheimer reaction of relapsing fever. (6132178)
1983
34
Bleeding in louse-borne relapsing fever. I. Clinical studies in 37 patients. (5157439)
1971
35
Tick-borne relapsing fever in Kashmir: mice inoculation--a diagnostic method of choice. (4964791)
1967
36
Experimental relapsing fever initiated by Borrelia hermsi. II. Sequential appearance of major serotypes in the rat. (5338694)
1967
37
International Sanitary Conventions and Regulations, plague and relapsing fever. (20604049)
1959
38
Antibiotic resistance of relapsing fever spirochetes. (13425439)
1956-1957
39
Infections of Ornithodoros ticks with relapsing fever spirochaetes, and the mechanisms of their transmission. (13303098)
1956
40
On the susceptibility of the guinea pig to the relapsing fever spirochete Borrelia duttonii. (13230801)
1954
41
The effect of protein deficiency on the resistance of rats to infection with spirochetes of relapsing fever. (14832488)
1951
42
Clinical manifestations of tick-borne relapsing fever with special reference to the disease in Cyprus. (18138841)
1949
43
Activation of latent kala-azar by malaria and relapsing fever. (18891450)
1948
44
Sterile splenic abscess after relapsing fever. (18909674)
1948
45
Comparative effectiveness of penicillins G, F, K, and X in experimental relapsing fever. (20262378)
1947
46
A case for diagnosis [relapsing fever?]. (20250491)
1947
47
Penicillin in the treatment of experimental relapsing fever in rats. (20998614)
1946
48
Weil-Felix and typhus complement-fixation tests in relapsing fever, with special reference to B. proteus OX-K agglutination. (21018821)
1946
49
Relapsing fever. (21065367)
1945
50
Relapsing fever; report of a sporadic outbreak, including treatment with penicillin. (21003743)
1945

Variations for Relapsing Fever

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Expression for genes affiliated with Relapsing Fever

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Relapsing Fever

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Pathways for genes affiliated with Relapsing Fever

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Compounds for genes affiliated with Relapsing Fever

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45Novoseek, 61Tocris Bioscience, 3BitterDB, 29IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Relapsing Fever according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1dutp459.8NTRK1, TNFRSF1A
2mevalonate459.8TNFRSF1A, MEFV, MVK
3c2ceramide459.8TNFRSF1A, NTRK1
4colchicine45 61 3 29 1113.7TNFRSF1A, MEFV, NTRK1
5phenylalanine459.6TNFRSF1A, MVK, NTRK1
6alanine459.2CFH, TNFRSF1A, MVK, NTRK1
7threonine459.2TNFRSF1A, NTRK1, MVK, AKAP13
8estradiol45 24 1111.0TNFRSF1A, NTRK1, AKAP13
9serine458.9CFH, TNFRSF1A, AKAP13, MVK, NTRK1
10atp45 299.7MVK, AKAP13, TNFRSF1A, ADSS, NTRK1
11tyrosine458.6CFH, MEFV, NTRK1, AKAP13, TNFRSF1A

GO Terms for genes affiliated with Relapsing Fever

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16Gene Ontology
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Cellular components related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:0056629.4PURA, PURB
2nucleusGO:0056347.2CCDC85B, MEFV, ELK3, AKAP13, TNFRSF1A, PURA

Biological processes related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of inflammatory responseGO:0507289.2MVK, MEFV, TNFRSF1A
2negative regulation of transcription, DNA-templatedGO:0458928.2CCDC85B, ELK3, PURA, PURB

Molecular functions related to Relapsing Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single-stranded DNA bindingGO:0036979.7PURB, PURA
2purine-rich negative regulatory element bindingGO:0324229.6ELK3, PURA
3SMAD bindingGO:0463329.4PURA, PURB
4protein bindingGO:0055156.7PURA, CFH, ADSS, AKAP13, ELK3, CCDC85B

Products for genes affiliated with Relapsing Fever

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Sources for Relapsing Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet