MCID: RLP003
MIFTS: 43

Relapsing Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Relapsing Fever

MalaCards integrated aliases for Relapsing Fever:

Name: Relapsing Fever 12 55 51 41 14 69

Characteristics:

Orphanet epidemiological data:

55
relapsing fever
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:13034
ICD10 32 A68 A68.9
ICD9CM 34 087 087.9
MeSH 41 D012061
Orphanet 55 ORPHA91547
MESH via Orphanet 42 D012061
UMLS via Orphanet 70 C0035021
ICD10 via Orphanet 33 A68.0 A68.1 A68.9
UMLS 69 C0035021

Summaries for Relapsing Fever

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection, has material basis in Borrelia, which is transmitted_by tick or transmitted_by body louse.

MalaCards based summary : Relapsing Fever is related to louse-borne relapsing fever and tick-borne relapsing fever, and has symptoms including recurrent fevers An important gene associated with Relapsing Fever is MVK (Mevalonate Kinase), and among its related pathways/superpathways are Photodynamic therapy-induced AP-1 survival signaling. and Cellular Transformation by HTLV1. The drugs Doxycycline and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spleen.

Related Diseases for Relapsing Fever

Diseases related to Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 louse-borne relapsing fever 34.0 ARSI CRP TNF
2 tick-borne relapsing fever 33.8 AKAP13 CLPX
3 lyme disease 30.6 CFH CRP TNF
4 leptospirosis 29.9 CRP TNF
5 peritonitis 29.6 CRP MEFV TNF
6 vasculitis 29.3 CRP MEFV TNF
7 epidemic typhus 11.4
8 trench fever 11.2
9 pediculus humanus corporis infestation 11.2
10 sodoku disease 10.9
11 tick infestation 10.9
12 multifocal choroiditis 10.4 CFH TNF
13 choroiditis 10.4 CFH TNF
14 haemophilus influenzae 10.4 CFH TNF
15 anterior uveitis 10.4 CFH TNF
16 posterior uveitis 10.4 CFH TNF
17 melancholia 10.4 CRP TNF
18 central nervous system vasculitis 10.4 CRP TNF
19 tuberculous peritonitis 10.4 CRP TNF
20 diverticulitis 10.4 CRP TNF
21 ischemic heart disease 10.4 CRP TNF
22 cellulitis 10.3 CRP TNF
23 streptococcal meningitis 10.3 CRP TNF
24 scrub typhus 10.3 CRP TNF
25 chronic gonococcal salpingitis 10.3 TNF TNFRSF1A
26 retinitis pigmentosa 75 10.3 TNF TNFRSF1A
27 proctitis 10.3 CRP TNF
28 paratyphoid fever 10.3 TNF TNFRSF1A
29 dystrophinopathies 10.3 TNF TNFRSF1A
30 pleural disease 10.3 CRP TNF
31 apnea, obstructive sleep 10.3 CRP TNF
32 pericoronitis 10.3 CRP TNFRSF1A
33 perinatal necrotizing enterocolitis 10.3 CRP TNF
34 systemic onset juvenile idiopathic arthritis 10.3 MEFV TNF
35 autoinflammation, panniculitis, and dermatosis syndrome 10.3 MEFV TNF
36 acute salpingitis 10.3 TNF TNFRSF1A
37 lymph node disease 10.3 CRP TNF
38 post-transplant lymphoproliferative disease 10.3 TNF TNFRSF1A
39 infective endocarditis 10.3 CRP TNF
40 hemorrhagic fever with renal syndrome 10.3 CRP TNF
41 erysipelas 10.3 MEFV TNF
42 suppurative cholangitis 10.3 CRP TNF
43 uterine anomalies 10.3 CRP TNF
44 chronic salpingitis 10.2 TNF TNFRSF1A
45 amyloidosis aa 10.2 CRP MEFV
46 hypersensitivity vasculitis 10.2 CRP MEFV
47 cervical adenitis 10.2 MEFV MVK
48 hypersensitivity reaction type iii disease 10.2 CRP MEFV
49 pancreas disease 10.2 CRP TNF
50 inflammatory myopathy with abundant macrophages 10.2 MEFV TNFRSF1A

Graphical network of the top 20 diseases related to Relapsing Fever:



Diseases related to Relapsing Fever

Symptoms & Phenotypes for Relapsing Fever

UMLS symptoms related to Relapsing Fever:


recurrent fevers

Drugs & Therapeutics for Relapsing Fever

Drugs for Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Anti-Bacterial Agents Phase 2, Phase 3
3 Anti-Infective Agents Phase 2, Phase 3
4 Antimalarials Phase 2, Phase 3
5 Antiparasitic Agents Phase 2, Phase 3
6 Antiprotozoal Agents Phase 2, Phase 3
7
Amphotericin B Approved, Investigational Phase 2 1397-89-3 5280965 14956
8
Caspofungin Approved Phase 2 162808-62-0, 179463-17-3 2826718 468682
9
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
10 Antifungal Agents Phase 2
11 Echinocandins Phase 2
12 Liposomal amphotericin B Phase 2
13 Antibodies
14 Immunoglobulins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment
2 A Study of Caspofungin, Liposomal Amphotericin B or the Combination of Both for Patients After Stem-Cell Transplantation Completed NCT00148148 Phase 2 caspofungin;liposomal amphotericin B
3 Tocilizumab in Patients With Schnitzler's Syndrome Recruiting NCT03046381 Phase 2 Tocilizumab
4 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Factors Completed NCT00933296
5 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases In Patients With Persistent Fever in Cambodia, Nepal, Democratic Republic of the Congo and Sudan (NIDIAG-Fever) Completed NCT01766830
6 Life Quality Study for PFAPA Patient Recruiting NCT02811705
7 Exercise Capacity and Physical Activity Levels in Newly Diagnosed Hematologic Malignant Patients Recruiting NCT03212560

Search NIH Clinical Center for Relapsing Fever

Cochrane evidence based reviews: relapsing fever

Genetic Tests for Relapsing Fever

Anatomical Context for Relapsing Fever

MalaCards organs/tissues related to Relapsing Fever:

38
Brain, Testes, Spleen, Neutrophil, Heart, Salivary Gland, B Cells

Publications for Relapsing Fever

Articles related to Relapsing Fever:

(show top 50) (show all 561)
# Title Authors Year
1
Colony formation in solid medium by the relapsing fever spirochetes Borrelia hermsii and Borrelia turicatae. ( 29169853 )
2018
2
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29333799 )
2018
3
Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. ( 27859692 )
2017
4
Identification and characterization of a histamine-binding lipocalin-like molecule from the relapsing fever tick Ornithodoros turicata. ( 29164729 )
2017
5
Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )
2017
6
Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated A gene in the tick-mammalian transmission cycle of relapsing fever spirochetes. ( 29127407 )
2017
7
Louse-borne relapsing fever in a refugee from Mali. ( 28161771 )
2017
8
Division of the genus Borrelia into two genera (corresponding to Lyme disease and relapsing fever groups) reflects their genetic and phenotypic distinctiveness and will lead to a better understanding of these two groups of microbes (Margos et al. (2016) There is inadequate evidence to support the division of the genus Borrelia. Int. J. Syst. Evol. Microbiol. doi: 10.1099/ijsem.0.001717). ( 28141502 )
2017
9
Relapsing Fever ( 28722942 )
2017
10
Detection of relapsing fever Borrelia spp., Bartonella spp. and Anaplasmataceae bacteria in argasid ticks in Algeria. ( 29145396 )
2017
11
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
12
Epidemiological study of relapsing fever borreliae detected in Haemaphysalis ticks and wild animals in the western part of Japan. ( 28362864 )
2017
13
In Vitro Susceptibility of the Relapsing-Fever Spirochete Borrelia miyamotoi to Antimicrobial Agents. ( 28674060 )
2017
14
Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )
2017
15
Development and optimization of an inA vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )
2017
16
Diagnosis of Louse-Borne Relapsing Fever despite Negative Microscopy in Two Asylum Seekers from Eastern Africa. ( 29016302 )
2017
17
Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies for Borrelia miyamotoi. ( 28154563 )
2017
18
A relapsing fever group Borrelia sp. is widely distributed among wild deer in Japan. ( 29329785 )
2017
19
Transmission of Borrelia miyamotoi sensu lato relapsing fever group spirochetes in relation to duration of attachment by Ixodes scapularis nymphs. ( 28501504 )
2017
20
There Is a Method to the Madness: Strategies to Study Host Complement Evasion by Lyme Disease and Relapsing Fever Spirochetes. ( 28303129 )
2017
21
Relapsing fever causative agent in Southern Iran is a closely related species to East African borreliae. ( 28736193 )
2017
22
Relapsing fever in young refugees from East Africa. ( 28774320 )
2017
23
Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. ( 27417836 )
2016
24
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. ( 27430539 )
2016
25
Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )
2016
26
Relapsing fever in asylum seekers from Somalia arriving in Belgium in August 2015. ( 27112219 )
2016
27
Louse-borne relapsing fever in a refugee from Somalia arriving in Belgium. ( 27356309 )
2016
28
Louse-Borne Relapsing Fever (Borrelia recurrentis) in a Somali Refugee Arriving in Italy: A Re-emerging Infection in Europe? ( 27149282 )
2016
29
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. ( 27100337 )
2016
30
Hard Tick Relapsing Fever Due to Borrelia Miyamotoi in a Child. ( 27626914 )
2016
31
Lyme disease and relapsing fever Borrelia elongate through zones of peptidoglycan synthesis that mark division sites of daughter cells. ( 27506799 )
2016
32
Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. ( 27284141 )
2016
33
Detection and Characterization of the Emerging Relapsing Fever Pathogen, Borrelia miyamotoi, from the Ixodes ricinus Tick in the Rural Trakya (Thrace) Region of Northwestern Turkey. ( 27788060 )
2016
34
Louse-borne relapsing fever - report of four cases in Switzerland, June-December 2015. ( 27188655 )
2016
35
Correction: Expression of the Tick-Associated Vtp Protein of Borrelia hermsii in a Murine Model of Relapsing Fever. ( 27074024 )
2016
36
Louse-borne relapsing fever among East African refugees in Europe. ( 26872415 )
2016
37
Louseborne Relapsing Fever in Young Migrants, Sicily, Italy, July-September 2015. ( 26690334 )
2016
38
Where Are the Ticks? Solving the Mystery of a Tickborne Relapsing Fever Outbreak at a Youth Camp. ( 27188066 )
2016
39
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. ( 27832805 )
2016
40
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. ( 27430543 )
2016
41
Borrelia sp. phylogenetically different from Lyme disease- and relapsing fever-related Borrelia spp. in Amblyomma varanense from Python reticulatus. ( 27342652 )
2016
42
Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )
2016
43
Expression of the Tick-Associated Vtp Protein of Borrelia hermsii in a Murine Model of Relapsing Fever. ( 26918760 )
2016
44
Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions. ( 27852620 )
2016
45
Louseborne Relapsing Fever among East African Refugees, Italy, 2015. ( 26812354 )
2016
46
Molecular identification of Borrelia genus in questing hard ticks from Portugal: Phylogenetic characterization of two novel Relapsing Fever-like Borrelia sp. ( 26976475 )
2016
47
Louse-Borne Relapsing Fever with Meningeal Involvement in an Immigrant from Somalia to Italy, October 2015. ( 26938933 )
2016
48
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. ( 27650717 )
2016
49
Epidemiological Study of Endemic Relapsing Fever in Hamadan Province, West of Iran. ( 28032111 )
2016
50
Insights into Borrelia miyamotoi infection from an untreated case demonstrating relapsing fever, monocytosis and a positive C6 Lyme serology. ( 27412815 )
2016

Variations for Relapsing Fever

Expression for Relapsing Fever

Search GEO for disease gene expression data for Relapsing Fever.

Pathways for Relapsing Fever

GO Terms for Relapsing Fever

Biological processes related to Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CRP MEFV TNF TNFRSF1A
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.58 AKAP13 TNF TNFRSF1A
3 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 TNF TNFRSF1A
4 regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 9.46 TNF TNFRSF1A
5 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.43 TNF TNFRSF1A
6 negative regulation of inflammatory response GO:0050728 9.33 MEFV MVK TNFRSF1A
7 positive regulation of ceramide biosynthetic process GO:2000304 9.32 TNF TNFRSF1A
8 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
9 death-inducing signaling complex assembly GO:0071550 8.96 TNF TNFRSF1A
10 regulation of establishment of endothelial barrier GO:1903140 8.62 TNF TNFRSF1A

Sources for Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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