MCID: RLP001
MIFTS: 70

Relapsing Polychondritis malady

Rare diseases, Nephrological diseases, Bone diseases categories

Summaries for Relapsing Polychondritis

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Relapsing polychondritis is a condition that affects connective tissue, particularly cartilage. cartilage is a tough but flexible tissue that covers the ends of your bones at a joint, and gives shape and support to other parts of your body. early symptoms of relapsing polychondritis may include irritation, redness, and swelling (inflammation) of the ears, nose, and/or eye. a person may experience arthritis involving multiple joints as well.  relapsing polychondritis may affect the inner ear, heart, and skin and can cause sensorineural deafness, vertigo, aortic valve regurgitation, mitral valve regurgitation, and aneurysms. last updated: 1/6/2010

MalaCards: Relapsing Polychondritis, also known as chronic atrophic polychondritis, is related to arthritis and encephalitis, and has symptoms including conductive deafness/hearing loss, biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp and chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis. An important gene associated with Relapsing Polychondritis is COMP (cartilage oligomeric matrix protein), and among its related pathways are PERK regulated gene expression and Cytokines and Inflammatory Response. The drug dapsone and the compounds azithromycin and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and skin, and related mouse phenotypes are normal and liver/biliary system.

Wikipedia:66 Relapsing polychondritis (also known as \"Atrophic polychondritis,\" and \"Systemic chondromalacia\") is... more...

Aliases & Classifications for Relapsing Polychondritis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 50Orphanet, 63UMLS, 59SNOMED-CT, 36MeSH, 64UMLS via Orphanet, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

50
relapsing polychondritis:
Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

relapsing polychondritis 9 44 11 50
chronic atrophic polychondritis 44
polychondritis, relapsing 63
chondromalacia, systemic 9
polychondritis relapsing 46
recurrent polychondritis 44
recurrence 63


External Ids:

Disease Ontology9 DOID:2556
MeSH36 D011081
UMLS via Orphanet64 C0032453
MESH via Orphanet37 D011081
ICD10 via Orphanet27 M94.1
SNOMED-CT via Orphanet60 72275000
ICD1026 M94.1

Related Diseases for Relapsing Polychondritis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Relapsing Polychondritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 253)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0IL8, COL2A1
2encephalitis30.9CCL2, CCL4
3vasculitis30.7CRP, APOH, IL1RAPL2, CCL2, CD79A
4meningitis30.7CCL4, IL8, CRP, CD79A
5ankylosing spondylitis30.6CD79A, CRP
6uveitis30.5CCL2, IFNG, IL10, CCL4
7epidermolysis bullosa acquisita30.5CD79A, MATN1
8hepatitis c30.4IL10, IFNG, CCL4
9psoriatic arthritis30.4CRP, COMP, IL1RAPL2
10prostatitis30.3CD79A
11purpura30.3CD79A
12sarcoidosis30.3IL1RAPL2, IFNG, CCL2, CCL4
13thyroiditis30.3CD79A
14cryoglobulinemia30.2APOH, CD79A
15psoriasis30.2IFNG, IL7, IL1RAPL2, IL10, IL8, S100A8
16asthma30.2IL8, CD79A, S100A8, IL10, CCL4, CCL2
17glomerulonephritis30.2CD79A, CCL2, CCL4
18bacterial meningitis30.2IL8, CRP, CCL4
19rheumatoid arthritis30.2CCL2, CCL4, IFNG, IL7, IL1RAPL2, CD79A
20vascular disease30.2CRP, CCL2, APOH
21pulmonary fibrosis30.2CCL4, CCL2, IL8
22amyloidosis30.1CD79A, CRP, IL1RAPL2
23myeloma30.1CCL4, CD79A, IL1RAPL2, IL7
24eosinophilia30.1IFNG, IL10, IL8, CD79A
25arthropathy30.1CRP, IL1RAPL2, COMP, S100A8, COL2A1
26synovitis30.0IL7, IL8, COMP, MATN1, CRP, COL2A1
27leukemia30.0CCL4, IFNG, S100A8, IL1RAPL2, IL7, CD79A
28systemic lupus erythematosus29.9CD79A, S100A8, CRP, COMP, IL10, IL1RAPL2
29pneumonia29.8CRP, S100A8, IL10, CD79A, IL8, IL1RAPL2
30ulcerative colitis29.8CRP, IL8, IL10, IL1RAPL2, IL7, CD79A
31myelodysplastic syndromes10.7
32laryngotracheitis10.5
33scleritis10.5
34limbic encephalitis10.5
35aortitis10.4
36cerebritis10.4
37dementia10.4
38antiphospholipid syndrome10.4
39wegener's granulomatosis10.4
40spondylitis10.4
41aneurysm10.4
42orchitis10.3
43pyoderma gangrenosum10.3
44tracheal stenosis10.3
45aseptic meningitis10.3
46alopecia10.3
47alopecia areata10.3
48hypopyon10.3
49laryngitis10.3
50lupus erythematosus10.3

Graphical network of the top 20 diseases related to Relapsing Polychondritis:



Diseases related to relapsing polychondritis

Symptoms for Relapsing Polychondritis

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50Orphanet
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Symptoms:

50 (show all 63)
  • conductive deafness/hearing loss
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • tracheal atresia/stenosis
  • arterial aneurism (excluding aorta)
  • aortic root dilatation/dilation/aneurysm
  • external ear anomalies
  • endocardium anomalies/fibroelastosis/endocarditis
  • dizziness
  • chondritis/cartilage inflammation
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • vascularitis/vasculitides/arteritis
  • palpebral edema/periorbital edema
  • sensorineural deafness/hearing loss
  • pinnae chondritis
  • nasal chondritis/nose chondritis
  • cartilage destruction/chondrolysis
  • anomalies of nose and olfaction
  • enanthema/aphtosa/aphta/leukoplakia
  • tracheomalacia/tracheobronchomalacia
  • tinnitus
  • arterial embolism/thrombosis
  • proptosis/exophthalmos
  • renal glomerular defect/glomerulopathy
  • purpura/petichiae
  • abnormal cry/voice/phonation disorder/nasal speech
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • articular/joint pain/arthralgia
  • laryngomalacia
  • fever/chilling
  • cranial nerves palsy
  • renal failure
  • asthenia/fatigue/weakness
  • proteinuria
  • restricted joint mobility/joint stiffness/ankylosis
  • arthritis/synovitis/synovial proliferation
  • repeat respiratory infections
  • cataract/lens opacification
  • early death/lethality
  • encephalitis
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • cardiac rhythm disorder/arrhythmia
  • hepatitis/icterus/cholestasis
  • anaemia
  • myelodysplastic syndrome
  • venous thrombosis/phlebitis/thrombophlebitis
  • osteolysis/osteoclasia/bone destruction/erosions
  • hematuria/microhematuria
  • myocardium anomalies/myocarditis
  • angor pectoris/myocardial infarction
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • urticaria
  • autoimmunity/autoimmune reaction/autoantibodies
  • gangrena/necrosis
  • cough
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • heart/cardiac failure
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • macules
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • chronic skin infection/ulcerations/ulcers/cancrum
  • ataxia/incoordination/trouble of the equilibrium

Drugs & Therapeutics for Relapsing Polychondritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Relapsing Polychondritis

Drug clinical trials:

Search ClinicalTrials for Relapsing Polychondritis

Search NIH Clinical Center for Relapsing Polychondritis

Search CenterWatch for Relapsing Polychondritis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Relapsing Polychondritis

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Anatomical Context for Relapsing Polychondritis

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34MalaCards
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MalaCards organs/tissues related to Relapsing Polychondritis:

34
Heart, Bone, Skin, Eye, Lung, Bone marrow, Myeloid, Trachea, Brain, Kidney, Pituitary, Testes, Prostate, Thyroid, Monocytes, T cells

Animal Models for Relapsing Polychondritis or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Relapsing Polychondritis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6CCL2, IL10, CD79A, COL2A1, COMP, IFNG
2MP:00053708.5IFNG, CCL2, IL10, COL2A1, CD1D
3MP:00030128.4IL7, IL10, MATN1, CD79A, IFNG
4MP:00053858.3CD1D, CRP, COL2A1, IL10, CCL2, IFNG
5MP:00053908.1IFNG, COMP, CCL2, COL2A1, MATN1, CD1D
6MP:00053978.0IL8, CD79A, IL10, IL7, IFNG, CCL2
7MP:00053877.3IFNG, CD79A, CD1D, CRP, COL2A1, COMP

Publications for Relapsing Polychondritis

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Sources:
53PubMed
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Articles related to Relapsing Polychondritis:

(show top 50)    (show all 497)
idTitleAuthorsYear
1
Tracheobronchial involvement in relapsing polychondritis diagnosed on endobronchial ultrasound. (23545679)
2013
2
Case of relapsing polychondritis showing elevation of anti-type II collagen antibody titer. (23855351)
2013
3
Relapsing polychondritis: response to tocilizumab and association with colitis. (24048111)
2013
4
Abatacept in relapsing polychondritis. (23956250)
2013
5
Relapsing polychondritis coexisting with immune thrombocytopenic purpura: an unusual association. (23024116)
2013
6
Repair of a complex thoracic aneurysm from relapsing polychondritis. (23657635)
2013
7
Occurrence of relapsing polychondritis with a rising cANCA titre in a cANCA-positive systemic and cerebral vasculitis patient. (23417970)
2013
8
18F]fluorodeoxyglucose positron emission tomography imaging in a case of relapsing polychondritis. (22829695)
2012
9
Red eyes and red ears: relapsing polychondritis. (23254506)
2012
10
Sustained response to tocilizumab, anti-IL-6 antibody, following anti-TNF-I+ failure in a patient with relapsing polychondritis complicated by aortitis. (22298790)
2012
11
Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. (22051026)
2011
12
Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab. (20495939)
2010
13
Relapsing polychondritis and airway involvement. (19017885)
2009
14
Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis. (19106169)
2009
15
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
16
Fluorodeoxyglucose PET in relapsing polychondritis. (18234765)
2008
17
Relapsing polychondritis in a patient with lupus erythematosus: another manifestation of neutrophilic lupus? (18594144)
2008
18
"Prominent ear sign" on diffusion-weighted magnetic resonance imaging in relapsing polychondritis. (18770003)
2008
19
Crohn's disease, relapsing polychondritis and epidermolysis bullosa acquisita: an immune-mediated inflammatory syndrome. (18238795)
2008
20
Proteomic surveillance of autoantigens in relapsing polychondritis. (16490929)
2006
21
Uncommon CT findings in relapsing polychondritis. (16155171)
2005
22
Chronic lymphocytic leukaemia and concomitant relapsing polychondritis: a report on one treatment for the combined manifestation of two diseases. (15855184)
2005
23
Brain magnetic resonance imaging and single photon emission computerized tomography findings in a case of relapsing polychondritis showing cognitive impairment and personality changes. (15694246)
2005
24
Relapsing polychondritis. (15454129)
2004
25
Cardiac manifestations of relapsing polychondritis--a case report. (15378125)
2004
26
Bilateral ear swelling and cough. Relapsing polychondritis. (15171083)
2004
27
Obstructive sleep apnoea/hypopnoea as the initial presentation of relapsing polychondritis. (14994981)
2004
28
Relapsing polychondritis in an elderly male. (15260398)
2003
29
Syncope in a patient with relapsing polychondritis. (14644874)
2003
30
Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. (11817597)
2002
31
Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis. (12223103)
2002
32
Colchicine and indomethacin for the treatment of relapsing polychondritis. (11807462)
2002
33
Concurrence of relapsing polychondritis and psoriatic arthritis. (17041338)
2002
34
Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis. (11465724)
2001
35
Microscopic polyangiitis in a patient with relapsing polychondritis. (11257169)
2001
36
Anesthetic management of a patient with relapsing polychondritis. (10392683)
1999
37
Pulmonary manifestations of ankylosing spondylitis and relapsing polychondritis. (9917964)
1998
38
Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. (9214424)
1997
39
Tc-99m MDP bone scintigraphy in relapsing polychondritis. (9099491)
1997
40
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. (9002018)
1997
41
Joint symptoms in relapsing polychondritis. (7586772)
1995
42
Relapsing polychondritis associated with rheumatoid arthritis. (8683835)
1995
43
A diagnostic dilemma: Wegener's granulomatosis, relapsing polychondritis or both? (8258052)
1993
44
Relapsing polychondritis as a secondary phenomenon of primary systemic vasculitis. (8311544)
1993
45
Preferential cellular and humoral immune reactivities to native and denatured collagen types IX and XI in a patient with fatal relapsing polychondritis. (8230032)
1993
46
Cryptococcal epididymo-orchitis complicating steroid therapy for relapsing polychondritis. (1780194)
1991
47
Relapsing polychondritis and Reiter's syndrome. (1895275)
1991
48
Relapsing polychondritis. (2916981)
1989
49
Relapsing polychondritis. (3522446)
1986
50
Relapsing polychondritis studied by computed tomography. (4048461)
1985

Variations for Relapsing Polychondritis

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Expression for genes affiliated with Relapsing Polychondritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Relapsing Polychondritis

Search GEO for disease gene expression data for Relapsing Polychondritis.

Pathways for genes affiliated with Relapsing Polychondritis

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 54QIAGEN, 61Thomson Reuters, 31KEGG, 55R&D Systems
See all sources

Pathways related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8IL8, CCL2
29.7IL10, IFNG
39.7IL10, IFNG
49.7IL8, IFNG
5
Show member pathways
Type III interferon signaling39
9.5IL10, IL7, IFNG
6
Show member pathways
thioredoxin pathway39
9.4CCL2, IFNG, CRP
7
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.4IFNG, IL10, CD79A
8
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
9.4CCL2, IFNG, IL10
99.4IL8, IFNG, CCL2
109.3IFNG, IL10, IL8
11
Show member pathways
9.2IL8, CCL4, CCL2
129.1CCL2, IFNG, IL8, COL2A1
13
Show member pathways
9.1IL10, IFNG, CCL4
14
Show member pathways
9.1IL8, IFNG, CCL4
15
Show member pathways
8.9COL2A1, IL8, CCL4, CCL2
168.8COMP, IL8, IL10, IFNG, CCL2
178.6IFNG, IL10, IL8, COL2A1, CD1D
18
Show member pathways
8.6CCL2, CCL4, IL7, IL10, IL8
19
Show member pathways
8.6CCL2, CCL4, IL7, IL10, IL8
20
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.4CCL2, CCL4, IFNG, IL10, IL8
21
Show member pathways
8.3CCL2, CCL4, IL7, IL10, IL8, COL2A1
22
Show member pathways
8.1CCL2, CCL4, IFNG, IL7, IL10, IL8
23
Show member pathways
8.1CCL2, CCL4, IFNG, IL7, IL10, IL8

Compounds for genes affiliated with Relapsing Polychondritis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 25HMDB
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Compounds related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1azithromycin46 1210.5IL10, IL8, CRP, CD79A
2alpha-galactosylceramide469.3CD1D, IL10, IFNG, IL7
3okt3469.3CRP, IL10, IL7, IFNG, CD79A
4polymyxin b469.3IL8, IFNG, CCL2, IL10
58-isoprostane469.2CCL2, CRP, APOH, IL8, IL10
6il-12469.2IL8, IL10, IL7, IFNG, CCL2
7toxin-1469.2IL8, IL10, CCL4, CCL2
8mcp 1469.2IL10, CCL2, IL8, CCL4
9mip 1alpha469.2CCL2, CCL4, IL10, IL8
10gm-csf46 3010.1IL10, IFNG, CCL2, IL8
11imiquimod46 62 30 1212.1IL8, IFNG, IL10, IL1RAPL2
12lipoteichoic acid469.1IL8, IL10, CCL2, APOH
13sulfasalazine30 46 52 1212.1CCL2, IL1RAPL2, CD79A, CRP, IL8
14alginate469.0COMP, MATN1, COL2A1, CD79A
15groalpha469.0CCL4, IL8, CCL2, IL10
16amphotericin b468.9CRP, IL1RAPL2, CCL4, IFNG
17cyclophosphamide46 52 1210.8APOH, CCL2, IL7, IL1RAPL2, CRP, IL10
18infliximab46 52 1210.8IFNG, IL1RAPL2, IL10, COMP, CRP, APOH
19adalimumab46 52 1210.8COMP, IFNG, IL1RAPL2, IL10, CRP, CD79A
20triptolide468.8CCL4, IL8, CCL2, IFNG
21p00001468.8S100A8, CRP, COMP, IL1RAPL2
22tarc468.8CCL2, IFNG, CCL4, IL10, IL8
23ccl346 309.8IL10, IL8, IFNG, CCL4, CCL2
24fibrinogen468.7CD79A, IL7, APOH, CCL2, IL1RAPL2, CRP
25glycosaminoglycan468.7IL1RAPL2, COL2A1, CCL4, COMP, MATN1
26neopterin468.7IFNG, CD79A, CRP, IL8, IL10, IL1RAPL2
27etanercept46 52 1210.5IL1RAPL2, IFNG, APOH, IL8, CRP, COMP
28sb 20358046 629.4CCL2, CRP, IL8, CCL4, IL10, IFNG
29ivig468.2IL1RAPL2, IL10, CRP, CD79A, IFNG, CCL4
30allergens468.1S100A8, IL10, IL7, IFNG, CCL4, CD79A
31methotrexate52 46 1210.1CD79A, IL10, COMP, CRP, S100A8, APOH
32il 10468.1CCL2, IFNG, CCL4, IL1RAPL2, IL10, IL7
33simvastatin46 52 62 30 25 1213.0CCL4, CRP, IL8, IL10, IFNG, IL1RAPL2
34cyclosporin a46 30 6210.0IFNG, IL10, IL1RAPL2, IL8, CD79A, CCL4
35prednisolone46 30 129.9APOH, IL10, IL1RAPL2, IFNG, CCL4, COMP
36pge2467.7IL10, IL1RAPL2, IL7, CCL4, IL8, IFNG
37lipid467.5CCL2, IL7, COL2A1, CRP, S100A8, CD1D
38cycloheximide467.5CCL2, IFNG, IL7, CCL4, CRP, COL2A1
39cysteine467.5IL7, CCL4, COMP, S100A8, IL8, CD79A
40creatinine467.5APOH, CCL2, CCL4, IL1RAPL2, COMP, CRP
41cholesterol46 30 25 1210.4CCL4, S100A8, APOH, CRP, IL1RAPL2, IL7
42oxygen46 258.3COL2A1, APOH, S100A8, CCL2, CCL4, IL8
43rantes467.2IL10, IL8, IL1RAPL2, IL7, IFNG, S100A8
44vegf467.2CRP, IL7, IL1RAPL2, IL10, IL8, CD79A
45histamine46 30 259.0CCL2, IL7, IL1RAPL2, CCL4, IL10, IL8
46endotoxin466.9APOH, CCL2, CCL4, IFNG, IL1RAPL2, IL10
47dexamethasone46 52 30 129.7COL2A1, CCL2, S100A8, IL8, IL10, IL1RAPL2
48calcium46 52 25 129.6COL2A1, MATN1, COMP, IL1RAPL2, CRP, S100A8
49retinoic acid46 257.5COL2A1, COMP, IL1RAPL2, MATN1, CD1D, CD79A
50nitric oxide46 25 128.3APOH, IL10, IL1RAPL2, COL2A1, IL7, IFNG

GO Terms for genes affiliated with Relapsing Polychondritis

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Sources:
17Gene Ontology
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Cellular components related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055766.4CCL4, IFNG, IL7, IL8, COMP, COL2A1
2extracellular spaceGO:0056156.0S100A8, APOH, CCL2, CCL4, IFNG, IL7

Biological processes related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.0IL10, IFNG
2response to molecule of bacterial originGO:0022379.9IL8, IL10
3regulation of gene expressionGO:0104689.9COL2A1, IL10, IL7
4organ morphogenesisGO:0098879.8CCL2, IL7, COMP
5B cell proliferationGO:0421009.8CD79A, IL10
6humoral immune responseGO:0069599.7CCL2, IFNG, IL7
7negative regulation of growth of symbiont in hostGO:0441309.7IL10, IFNG
8cellular response to fibroblast growth factor stimulusGO:0443449.7CCL2, IL8
9endoplasmic reticulum unfolded protein responseGO:0309689.6CCL2, IFNG, IL8
10response to activityGO:0148239.5IL10, CCL2
11cellular response to lipopolysaccharideGO:0712229.3CCL2, IFNG, IL10, IL8
12response to ethanolGO:0454719.2S100A8, CRP, CCL2
13cellular component movementGO:0069289.2CCL4, IFNG, IL8
14defense response to bacteriumGO:0427429.0S100A8, IL10, IFNG
15neutrophil chemotaxisGO:0305938.8CCL2, IFNG, IL8, S100A8
16inflammatory responseGO:0069548.0S100A8, CRP, IL8, IL10, CCL4, CCL2

Molecular functions related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:0082019.7COMP, CCL2, APOH
2chemokine activityGO:0080098.9CCL2, CCL4, IL8
3cytokine activityGO:0051258.7IL10, IL7, IFNG, CCL4

Products for genes affiliated with Relapsing Polychondritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Relapsing Polychondritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet