MCID: RLP001
MIFTS: 72

Relapsing Polychondritis malady

Rare diseases, Nephrological diseases, Bone diseases categories

Summaries for Relapsing Polychondritis

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NIH Rare Diseases:43 Relapsing polychondritis is a condition that affects connective tissue, particularly cartilage. cartilage is a tough but flexible tissue that covers the ends of your bones at a joint, and gives shape and support to other parts of your body. early symptoms of relapsing polychondritis may include irritation, redness, and swelling (inflammation) of the ears, nose, and/or eye. a person may experience arthritis involving multiple joints as well.  relapsing polychondritis may affect the inner ear, heart, and skin and can cause sensorineural deafness, vertigo, aortic valve regurgitation, mitral valve regurgitation, and aneurysms. last updated: 1/6/2010

MalaCards based summary: Relapsing Polychondritis, also known as polychondritis, chronic atrophic, is related to arthritis and encephalitis, and has symptoms including abnormality of the nose, arthritis and arthralgia. An important gene associated with Relapsing Polychondritis is COMP (cartilage oligomeric matrix protein), and among its related pathways are PERK regulated gene expression and Cytokines and Inflammatory Response. The drug dapsone and the compounds azithromycin and alpha-galactosylceramide have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and skin, and related mouse phenotypes are normal and liver/biliary system.

Wikipedia:65 Relapsing polychondritis, also known as atrophic polychondritis,systemic chondromalacia) chronic... more...

Aliases & Classifications for Relapsing Polychondritis

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Sources:
10Disease Ontology, 43NIH Rare Diseases, 12DISEASES, 49Orphanet, 45Novoseek, 62UMLS, 57SNOMED-CT, 35MeSH, 36MESH via Orphanet, 28ICD10 via Orphanet, 63UMLS via Orphanet, 27ICD10
See all sources

Relapsing Polychondritis, Aliases & Descriptions:

Name: Relapsing Polychondritis 10 43 12 49
Polychondritis, Chronic Atrophic 62
Chronic Atrophic Polychondritis 43
Polychondritis, Relapsing 62
 
Polychondritis Relapsing 45
Chondromalacia, Systemic 10
Recurrent Polychondritis 43
Recurrence 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

49
relapsing polychondritis:
Prevalence: 1-9/1000000 (United States),1-9/1000000 (Worldwide); Age of onset: Adult; Age of death: adult


External Ids:

Disease Ontology10 DOID:2556
MeSH35 D011081
Orphanet49 728
MESH via Orphanet36 D011081
ICD10 via Orphanet28 M94.1
UMLS via Orphanet63 C0032453
ICD1027 M94.1

Related Diseases for Relapsing Polychondritis

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Diseases related to Relapsing Polychondritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0IL8, COL2A1
2encephalitis31.0CCL4, CCL2
3vasculitis30.9CD79A, CRP, IL1RAPL2, CCL2, APOH
4meningitis30.8CCL4, IL8, CRP, CD79A
5uveitis30.6CCL2, CCL4, IFNG, IL10
6rheumatoid arthritis30.5APOH, CCL2, CCL4, IFNG, IL7, IL1RAPL2
7epidermolysis bullosa acquisita30.4MATN1, CD79A
8psoriasis30.4CCL2, CCL4, IFNG, IL7, IL1RAPL2, IL10
9hepatitis c30.4IL10, IFNG, CCL4
10psoriatic arthritis30.4IL1RAPL2, COMP, CRP
11asthma30.4CCL2, CCL4, IFNG, IL7, IL10, IL8
12colitis30.3IFNG, IL7, IL1RAPL2, IL10, IL8
13prostatitis30.2CD79A
14purpura30.2CD79A
15thyroiditis30.2CD79A
16cryoglobulinemia30.2APOH, CD79A
17common variable immunodeficiency30.2CD79A, IL10
18glomerulonephritis30.2CD79A, CCL4, CCL2
19bacterial meningitis30.2CCL4, IL8, CRP
20vascular disease30.2APOH, CCL2, CRP
21pulmonary fibrosis30.2IL8, CCL4, CCL2
22systemic lupus erythematosus30.1APOH, CCL2, CCL4, IFNG, IL1RAPL2, IL10
23amyloidosis30.1IL1RAPL2, CRP, CD79A
24myeloma30.1CD79A, IL1RAPL2, IL7, CCL4
25eosinophilia30.1IFNG, IL10, IL8, CD79A
26arthropathy30.1IL1RAPL2, COMP, COL2A1, CRP, S100A8
27synovitis30.1IL7, IL8, COMP, COL2A1, MATN1, CRP
28leukemia30.1CCL4, IFNG, IL7, IL1RAPL2, S100A8, CD79A
29pneumonia30.0CCL2, IL1RAPL2, IL10, IL8, CRP, S100A8
30ulcerative colitis30.0CCL4, IFNG, IL7, IL1RAPL2, IL10, IL8
31myelodysplastic syndrome10.7
32aortitis10.6
33limbic encephalitis10.5
34laryngotracheitis10.5
35scleritis10.5
36cerebritis10.5
37dementia10.5
38spondylitis10.5
39antiphospholipid syndrome10.4
40respiratory failure10.4
41aneurysm10.4
42alopecia10.3
43orchitis10.3
44pyoderma gangrenosum10.3
45tracheal stenosis10.3
46aseptic meningitis10.3
47alopecia areata10.3
48hypopyon10.3
49laryngitis10.3
50lupus erythematosus10.3

Graphical network of the top 20 diseases related to Relapsing Polychondritis:



Diseases related to relapsing polychondritis

Symptoms for Relapsing Polychondritis

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Symptoms:

 49 (show all 63)
  • anomalies of nose and olfaction
  • nasal chondritis/nose chondritis
  • external ear anomalies
  • pinnae chondritis
  • articular/joint pain/arthralgia
  • arthritis/synovitis/synovial proliferation
  • chondritis/cartilage inflammation
  • asthenia/fatigue/weakness
  • proptosis/exophthalmos
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • cataract/lens opacification
  • palpebral edema/periorbital edema
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • dizziness
  • cough
  • abnormal cry/voice/phonation disorder/nasal speech
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • aortic root dilatation/dilation/aneurysm
  • arterial aneurism (excluding aorta)
  • vascularitis/vasculitides/arteritis
  • osteolysis/osteoclasia/bone destruction/erosions
  • restricted joint mobility/joint stiffness/ankylosis
  • cartilage destruction/chondrolysis
  • autoimmunity/autoimmune reaction/autoantibodies
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • tinnitus
  • sensorineural deafness/hearing loss
  • conductive deafness/hearing loss
  • chronic skin infection/ulcerations/ulcers/cancrum
  • urticaria
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • enanthema/aphtosa/aphta/leukoplakia
  • purpura/petichiae
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • hepatitis/icterus/cholestasis
  • laryngomalacia
  • tracheal atresia/stenosis
  • tracheomalacia/tracheobronchomalacia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • repeat respiratory infections
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • angor pectoris/myocardial infarction
  • heart/cardiac failure
  • arterial embolism/thrombosis
  • venous thrombosis/phlebitis/thrombophlebitis
  • gangrena/necrosis
  • renal glomerular defect/glomerulopathy
  • renal failure
  • proteinuria
  • hematuria/microhematuria
  • cranial nerves palsy
  • encephalitis
  • ataxia/incoordination/trouble of the equilibrium
  • hemiplegia/diplegia/hemiparesia/limb palsy
  • anaemia
  • myelodysplastic syndrome
  • early death/lethality

HPO human phenotypes related to Relapsing Polychondritis:

(show all 56)
id Description Frequency HPO Source Accession
1 abnormality of the nose hallmark (90%) HP:0000366
2 arthritis hallmark (90%) HP:0001369
3 arthralgia hallmark (90%) HP:0002829
4 external ear malformation hallmark (90%) HP:0008572
5 chondritis hallmark (90%) HP:0100662
6 chondritis of pinna hallmark (90%) HP:0200047
7 sinusitis typical (50%) HP:0000246
8 cataract typical (50%) HP:0000518
9 proptosis typical (50%) HP:0000520
10 limitation of joint mobility typical (50%) HP:0001376
11 abnormality of the voice typical (50%) HP:0001608
12 abnormality of the aortic valve typical (50%) HP:0001646
13 abnormality of the pericardium typical (50%) HP:0001697
14 vertigo typical (50%) HP:0002321
15 aneurysm typical (50%) HP:0002617
16 vasculitis typical (50%) HP:0002633
17 osteolysis typical (50%) HP:0002797
18 autoimmunity typical (50%) HP:0002960
19 abnormality of temperature regulation typical (50%) HP:0004370
20 dilatation of the ascending aorta typical (50%) HP:0005111
21 inflammatory abnormality of the eye typical (50%) HP:0100533
22 periorbital edema typical (50%) HP:0100539
23 cartilage destruction typical (50%) HP:0100773
24 renal insufficiency occasional (7.5%) HP:0000083
25 proteinuria occasional (7.5%) HP:0000093
26 abnormality of the oral cavity occasional (7.5%) HP:0000163
27 tinnitus occasional (7.5%) HP:0000360
28 conductive hearing impairment occasional (7.5%) HP:0000405
29 sensorineural hearing impairment occasional (7.5%) HP:0000407
30 hematuria occasional (7.5%) HP:0000790
31 urticaria occasional (7.5%) HP:0001025
32 hypermelanotic macule occasional (7.5%) HP:0001034
33 abnormality of the liver occasional (7.5%) HP:0001392
34 laryngomalacia occasional (7.5%) HP:0001601
35 abnormality of the mitral valve occasional (7.5%) HP:0001633
36 congestive heart failure occasional (7.5%) HP:0001635
37 abnormality of the myocardium occasional (7.5%) HP:0001637
38 coronary artery disease occasional (7.5%) HP:0001677
39 anemia occasional (7.5%) HP:0001903
40 subcutaneous hemorrhage occasional (7.5%) HP:0001933
41 respiratory insufficiency occasional (7.5%) HP:0002093
42 recurrent respiratory infections occasional (7.5%) HP:0002205
43 incoordination occasional (7.5%) HP:0002311
44 encephalitis occasional (7.5%) HP:0002383
45 tracheal stenosis occasional (7.5%) HP:0002777
46 tracheomalacia occasional (7.5%) HP:0002779
47 myelodysplasia occasional (7.5%) HP:0002863
48 abnormality of the endocardium occasional (7.5%) HP:0004306
49 hemiplegia/hemiparesis occasional (7.5%) HP:0004374
50 thrombophlebitis occasional (7.5%) HP:0004418
51 arterial thrombosis occasional (7.5%) HP:0004420
52 cranial nerve paralysis occasional (7.5%) HP:0006824
53 arrhythmia occasional (7.5%) HP:0011675
54 gangrene occasional (7.5%) HP:0100758
55 glomerulopathy occasional (7.5%) HP:0100820
56 skin ulcer occasional (7.5%) HP:0200042

Drugs & Therapeutics for Relapsing Polychondritis

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Drug clinical trials:

Search ClinicalTrials for Relapsing Polychondritis

Search NIH Clinical Center for Relapsing Polychondritis

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Relapsing Polychondritis

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Anatomical Context for Relapsing Polychondritis

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MalaCards organs/tissues related to Relapsing Polychondritis:

33
Heart, Bone, Skin, Eye, Lung, Liver, Neutrophil, Bone marrow, Myeloid, Trachea, Brain, Kidney, Thyroid, Prostate, Testes, Monocytes, T cells, B cells, Pituitary

Animal Models for Relapsing Polychondritis or affiliated genes

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MGI Mouse Phenotypes related to Relapsing Polychondritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.6CCL2, IFNG, IL10, COMP, COL2A1, CD79A
2MP:00053708.5CCL2, IFNG, IL10, COL2A1, CD1D
3MP:00030128.4IFNG, IL7, IL10, MATN1, CD79A
4MP:00053858.3CD1D, CRP, COL2A1, IL10, IFNG, CCL2
5MP:00053908.1CCL2, IFNG, IL10, COMP, COL2A1, MATN1
6MP:00053978.0CCL2, IFNG, IL7, IL10, IL8, CD1D
7MP:00053877.3CD79A, CCL2, IFNG, IL7, IL10, IL8

Publications for Relapsing Polychondritis

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Articles related to Relapsing Polychondritis:

(show top 50)    (show all 533)
idTitleAuthorsYear
1
Limbic encephalitis associated with relapsing polychondritis responded to infliximab and maintained its condition without recurrence after discontinuation: a case report and review of the literature. (25741046)
2014
2
Cardiac involvement in relapsing polychondritis. (24917640)
2014
3
Tracheobronchial involvement in relapsing polychondritis diagnosed on endobronchial ultrasound. (23545679)
2013
4
Case of relapsing polychondritis showing elevation of anti-type II collagen antibody titer. (23855351)
2013
5
Relapsing polychondritis: response to tocilizumab and association with colitis. (24048111)
2013
6
Abatacept in relapsing polychondritis. (23956250)
2013
7
Relapsing polychondritis coexisting with immune thrombocytopenic purpura: an unusual association. (23024116)
2013
8
Repair of a complex thoracic aneurysm from relapsing polychondritis. (23657635)
2013
9
18F]fluorodeoxyglucose positron emission tomography imaging in a case of relapsing polychondritis. (22829695)
2012
10
Red eyes and red ears: relapsing polychondritis. (23254506)
2012
11
Sustained response to tocilizumab, anti-IL-6 antibody, following anti-TNF-I+ failure in a patient with relapsing polychondritis complicated by aortitis. (22298790)
2012
12
Meningoencephalitis or meningitis in relapsing polychondritis: four case reports and a literature review. (22051026)
2011
13
Treatment of relapsing polychondritis with the TNF-alpha antagonist adalimumab. (20495939)
2010
14
Relapsing polychondritis and airway involvement. (19017885)
2009
15
Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis. (19106169)
2009
16
Autoantibodies to glutamate receptor GluRepsilon2 in a patient with limbic encephalitis associated with relapsing polychondritis. (19716567)
2009
17
Fluorodeoxyglucose PET in relapsing polychondritis. (18234765)
2008
18
Relapsing polychondritis in a patient with lupus erythematosus: another manifestation of neutrophilic lupus? (18594144)
2008
19
"Prominent ear sign" on diffusion-weighted magnetic resonance imaging in relapsing polychondritis. (18770003)
2008
20
Crohn's disease, relapsing polychondritis and epidermolysis bullosa acquisita: an immune-mediated inflammatory syndrome. (18238795)
2008
21
Proteomic surveillance of autoantigens in relapsing polychondritis. (16490929)
2006
22
Uncommon CT findings in relapsing polychondritis. (16155171)
2005
23
Chronic lymphocytic leukaemia and concomitant relapsing polychondritis: a report on one treatment for the combined manifestation of two diseases. (15855184)
2005
24
Brain magnetic resonance imaging and single photon emission computerized tomography findings in a case of relapsing polychondritis showing cognitive impairment and personality changes. (15694246)
2005
25
Relapsing polychondritis. (15454129)
2004
26
Cardiac manifestations of relapsing polychondritis--a case report. (15378125)
2004
27
Bilateral ear swelling and cough. Relapsing polychondritis. (15171083)
2004
28
Obstructive sleep apnoea/hypopnoea as the initial presentation of relapsing polychondritis. (14994981)
2004
29
Relapsing polychondritis in an elderly male. (15260398)
2003
30
Syncope in a patient with relapsing polychondritis. (14644874)
2003
31
Identification of type II collagen peptide 261-273-specific T cell clones in a patient with relapsing polychondritis. (11817597)
2002
32
Cartilage-specific autoimmunity in animal models and clinical aspects in patients - focus on relapsing polychondritis. (12223103)
2002
33
Colchicine and indomethacin for the treatment of relapsing polychondritis. (11807462)
2002
34
Concurrence of relapsing polychondritis and psoriatic arthritis. (17041338)
2002
35
Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis. (11465724)
2001
36
Microscopic polyangiitis in a patient with relapsing polychondritis. (11257169)
2001
37
Anesthetic management of a patient with relapsing polychondritis. (10392683)
1999
38
Pulmonary manifestations of ankylosing spondylitis and relapsing polychondritis. (9917964)
1998
39
Pregnancy in relapsing polychondritis: twenty-five pregnancies in eleven patients. (9214424)
1997
40
Tc-99m MDP bone scintigraphy in relapsing polychondritis. (9099491)
1997
41
Relapsing polychondritis: clinical and immunogenetic analysis of 62 patients. (9002018)
1997
42
Joint symptoms in relapsing polychondritis. (7586772)
1995
43
Relapsing polychondritis associated with rheumatoid arthritis. (8683835)
1995
44
A diagnostic dilemma: Wegener's granulomatosis, relapsing polychondritis or both? (8258052)
1993
45
Relapsing polychondritis as a secondary phenomenon of primary systemic vasculitis. (8311544)
1993
46
Preferential cellular and humoral immune reactivities to native and denatured collagen types IX and XI in a patient with fatal relapsing polychondritis. (8230032)
1993
47
Cryptococcal epididymo-orchitis complicating steroid therapy for relapsing polychondritis. (1780194)
1991
48
Relapsing polychondritis. (2916981)
1989
49
Relapsing polychondritis. (3522446)
1986
50
Relapsing polychondritis studied by computed tomography. (4048461)
1985

Variations for Relapsing Polychondritis

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Expression for genes affiliated with Relapsing Polychondritis

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Search GEO for disease gene expression data for Relapsing Polychondritis.

Pathways for genes affiliated with Relapsing Polychondritis

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Pathways related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8IL8, CCL2
29.7IL10, IFNG
39.7IL10, IFNG
49.7IL8, IFNG
5
Show member pathways
Type III interferon signaling38
9.5IL10, IL7, IFNG
6
Show member pathways
thioredoxin pathway38
9.4CCL2, IFNG, CRP
7
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.4IFNG, IL10, CD79A
8
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.4CCL2, IFNG, IL10
99.4IL8, IFNG, CCL2
109.3IFNG, IL10, IL8
11
Show member pathways
9.2IL8, CCL4, CCL2
129.1CCL2, IFNG, IL8, COL2A1
13
Show member pathways
9.1IL10, IFNG, CCL4
14
Show member pathways
9.1IL8, IFNG, CCL4
15
Show member pathways
8.9COL2A1, IL8, CCL4, CCL2
168.8COMP, IL8, IL10, IFNG, CCL2
178.6IFNG, IL10, IL8, COL2A1, CD1D
18
Show member pathways
8.6CCL2, CCL4, IL7, IL10, IL8
19
Show member pathways
8.6CCL2, CCL4, IL7, IL10, IL8
20
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
8.4CCL2, CCL4, IFNG, IL10, IL8
21
Show member pathways
8.3CCL2, CCL4, IL7, IL10, IL8, COL2A1
22
Show member pathways
8.1CCL2, CCL4, IFNG, IL7, IL10, IL8
23
Show member pathways
8.1CCL2, CCL4, IFNG, IL7, IL10, IL8

Compounds for genes affiliated with Relapsing Polychondritis

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Compounds related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1azithromycin45 1310.5IL10, IL8, CRP, CD79A
2alpha-galactosylceramide459.3CD1D, IL10, IFNG, IL7
3okt3459.3CRP, IL10, IL7, IFNG, CD79A
4polymyxin b459.3IL8, IFNG, CCL2, IL10
58-isoprostane459.2CCL2, CRP, APOH, IL8, IL10
6il-12459.2IL8, IL10, IL7, IFNG, CCL2
7toxin-1459.2IL8, IL10, CCL4, CCL2
8mcp 1459.2IL10, CCL2, IL8, CCL4
9mip 1alpha459.2CCL2, CCL4, IL10, IL8
10gm-csf45 3010.1IL10, IFNG, CCL2, IL8
11imiquimod45 61 30 1312.1IL8, IFNG, IL10, IL1RAPL2
12lipoteichoic acid459.1IL8, IL10, CCL2, APOH
13sulfasalazine30 45 51 1312.1CCL2, IL1RAPL2, CD79A, CRP, IL8
14alginate459.0COMP, MATN1, COL2A1, CD79A
15groalpha459.0CCL4, IL8, CCL2, IL10
16amphotericin b458.9CRP, IL1RAPL2, CCL4, IFNG
17cyclophosphamide45 51 1310.8APOH, CCL2, IL7, IL1RAPL2, CRP, IL10
18infliximab45 51 1310.8IFNG, IL1RAPL2, IL10, COMP, CRP, APOH
19adalimumab45 51 1310.8COMP, IFNG, IL1RAPL2, IL10, CRP, CD79A
20triptolide458.8CCL4, IL8, CCL2, IFNG
21p00001458.8S100A8, CRP, COMP, IL1RAPL2
22tarc458.8CCL2, IFNG, CCL4, IL10, IL8
23ccl345 309.8IL10, IL8, IFNG, CCL4, CCL2
24fibrinogen458.7CD79A, IL7, APOH, CCL2, IL1RAPL2, CRP
25glycosaminoglycan458.7IL1RAPL2, COL2A1, CCL4, COMP, MATN1
26neopterin458.7IFNG, CD79A, CRP, IL8, IL10, IL1RAPL2
27etanercept45 51 1310.5IL1RAPL2, IFNG, APOH, IL8, CRP, COMP
28sb 20358045 619.4CCL2, CRP, IL8, CCL4, IL10, IFNG
29ivig458.2IL1RAPL2, IL10, CRP, CD79A, IFNG, CCL4
30allergens458.1S100A8, IL10, IL7, IFNG, CCL4, CD79A
31methotrexate51 45 1310.1CD79A, IL10, COMP, CRP, S100A8, APOH
32il 10458.1CCL2, IFNG, CCL4, IL1RAPL2, IL10, IL7
33simvastatin45 51 61 30 26 1313.0CCL4, CRP, IL8, IL10, IFNG, IL1RAPL2
34cyclosporin a45 30 6110.0IFNG, IL10, IL1RAPL2, IL8, CD79A, CCL4
35prednisolone45 30 139.9APOH, IL10, IL1RAPL2, IFNG, CCL4, COMP
36pge2457.7IL10, IL1RAPL2, IL7, CCL4, IL8, IFNG
37lipid457.5CCL2, IL7, COL2A1, CRP, S100A8, CD1D
38cycloheximide457.5CCL2, IFNG, IL7, CCL4, CRP, COL2A1
39cysteine457.5IL7, CCL4, COMP, S100A8, IL8, CD79A
40creatinine457.5APOH, CCL2, CCL4, IL1RAPL2, COMP, CRP
41cholesterol45 30 26 1310.4CCL4, S100A8, APOH, CRP, IL1RAPL2, IL7
42oxygen45 268.3COL2A1, APOH, S100A8, CCL2, CCL4, IL8
43rantes457.2IL10, IL8, IL1RAPL2, IL7, IFNG, S100A8
44vegf457.2CRP, IL7, IL1RAPL2, IL10, IL8, CD79A
45histamine45 30 269.0CCL2, IL7, IL1RAPL2, CCL4, IL10, IL8
46endotoxin456.9APOH, CCL2, CCL4, IFNG, IL1RAPL2, IL10
47dexamethasone45 51 30 139.7COL2A1, CCL2, S100A8, IL8, IL10, IL1RAPL2
48calcium45 51 26 139.6COL2A1, MATN1, COMP, IL1RAPL2, CRP, S100A8
49retinoic acid45 267.5COL2A1, COMP, IL1RAPL2, MATN1, CD1D, CD79A
50nitric oxide45 26 138.3APOH, IL10, IL1RAPL2, COL2A1, IL7, IFNG

GO Terms for genes affiliated with Relapsing Polychondritis

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Cellular components related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.4CCL2, CRP, MATN1, COL2A1, COMP, IL8
2extracellular spaceGO:00056156.0APOH, COL2A1, COMP, IL8, IL10, IL7

Biological processes related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:004534810.0IL10, IFNG
2response to molecule of bacterial originGO:00022379.9IL8, IL10
3regulation of gene expressionGO:00104689.9COL2A1, IL10, IL7
4organ morphogenesisGO:00098879.8CCL2, IL7, COMP
5B cell proliferationGO:00421009.8CD79A, IL10
6humoral immune responseGO:00069599.7CCL2, IFNG, IL7
7negative regulation of growth of symbiont in hostGO:00441309.7IL10, IFNG
8cellular response to fibroblast growth factor stimulusGO:00443449.7CCL2, IL8
9endoplasmic reticulum unfolded protein responseGO:00309689.6CCL2, IFNG, IL8
10response to activityGO:00148239.5IL10, CCL2
11cellular response to lipopolysaccharideGO:00712229.3CCL2, IFNG, IL10, IL8
12response to ethanolGO:00454719.2S100A8, CRP, CCL2
13cellular component movementGO:00069289.2CCL4, IFNG, IL8
14defense response to bacteriumGO:00427429.0S100A8, IL10, IFNG
15neutrophil chemotaxisGO:00305938.8CCL2, IFNG, IL8, S100A8
16inflammatory responseGO:00069548.0S100A8, CRP, IL8, IL10, CCL4, CCL2

Molecular functions related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00082019.7COMP, CCL2, APOH
2chemokine activityGO:00080098.9CCL2, CCL4, IL8
3cytokine activityGO:00051258.7IL10, IL7, IFNG, CCL4

Products for genes affiliated with Relapsing Polychondritis

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Sources for Relapsing Polychondritis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
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45Novoseek
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