MCID: RLP001
MIFTS: 69

Relapsing Polychondritis malady

Nephrological diseases, Bone diseases categories

Summaries for Relapsing Polychondritis

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Relapsing polychondritis is a condition that affects connective tissue, particularly cartilage. cartilage is a tough but flexible tissue that covers the ends of your bones at a joint, and gives shape and support to other parts of your body. early symptoms of relapsing polychondritis may include irritation, redness, and swelling (inflammation) of the ears, nose, and/or eye. a person may experience arthritis involving multiple joints as well.  relapsing polychondritis may affect the inner ear, heart, and skin and can cause sensorineural deafness, vertigo, aortic valve regurgitation, mitral valve regurgitation, and aneurysms. last updated: 1/6/2010

MalaCards: Relapsing Polychondritis, also known as chronic atrophic polychondritis, is related to pancreatitis and breast cancer, and has symptoms including renal glomerular defect/glomerulopathy, renal failure and proteinuria. An important gene associated with Relapsing Polychondritis is COMP (cartilage oligomeric matrix protein), and among its related pathways are Rho Family GTPases and Spinal Cord Injury. The drug dapsone and the compounds cycloheximide and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, bone and eye, and related mouse phenotypes are skeleton and immune system.

Wikipedia:63 Relapsing polychondritis (also known as \"Atrophic polychondritis,\" and \"Systemic chondromalacia\") is... more...

Aliases & Classifications for Relapsing Polychondritis

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 48Orphanet, 44Novoseek, 60UMLS, 34MeSH, 56SNOMED-CT, 61UMLS via Orphanet, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
relapsing polychondritis:
Age of onset: Variable


Aliases & Descriptions:

relapsing polychondritis 8 42 10 48
chronic atrophic polychondritis 42
polychondritis, relapsing 60
chondromalacia, systemic 8
polychondritis relapsing 44
recurrent polychondritis 42
recurrence 60


External Ids:

Disease Ontology8 DOID:2556
MeSH34 D011081
UMLS via Orphanet61 C0032453
MESH via Orphanet35 D011081
ICD10 via Orphanet26 M94.1
SNOMED-CT via Orphanet57 72275000
ICD1025 M94.1

Related Diseases for Relapsing Polychondritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Relapsing Polychondritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 2426)
idRelated DiseaseScoreTop Affiliating Genes
1pancreatitis31.1CRP, IL10
2breast cancer31.1IL1RAPL2, IL7, PRTN3, S100A8, CCL4
3prostate cancer31.0S100A8, IL7
4hepatocellular carcinoma31.0S100A8, IL1RAPL2
5osteomyelitis30.9CRP
6adenocarcinoma30.9IL1RAPL2, S100A8
7tonsillitis30.9CD79A, CRP
8acute pancreatitis30.9IL8, IL1RAPL2, IL10, CRP
9adenoma30.9S100A8
10ovarian cancer30.8IL1RAPL2
11arthritis30.8IL8, IL1RAPL2, IL10, MATN1, PRTN3, CRP
12colorectal cancer30.8S100A8
13candidiasis30.8IFNG, CD79A
14vasculitis30.8IL1RAPL2, CD79A, PRTN3, CRP, APOH, CCL2
15encephalitis30.7CCL2, CCL4
16acute leukemia30.7PRTN3, IL7
17esophagitis30.7S100A8
18herpes simplex30.7CD79A, IL7, IL1RAPL2
19peritonitis30.7CCL2, CRP, PRTN3
20melanoma30.7COL2A1, CCL4, IFNG, PRTN3, IL10, IL7
21meningitis30.7CCL4, CRP, CD79A, IL8
22otitis media30.6CD79A
23rheumatoid arthritis30.6CD1D, PRTN3, CRP, APOH, S100A8, IFNG
24scleritis30.6PRTN3
25astrocytoma30.6CCL4
26dementia30.6IL1RAPL2
27duodenitis30.5S100A8
28wegener's granulomatosis30.5PRTN3
29antiphospholipid syndrome30.5APOH, CD79A
30uveitis30.5IL10, IFNG, CCL2, CCL4
31myocardial infarction30.5IL1RAPL2, CRP
32cervical cancer30.5IL7
33myeloid leukemia30.4PRTN3
34bacterial vaginosis30.4IL8
35psoriasis30.4S100A8, IFNG, CCL2, CCL4, IL10, IL7
36alopecia areata30.4IFNG
37lupus erythematosus30.4CD79A, APOH
38hepatitis b30.4CD79A, IFNG
39ankylosing spondylitis30.4CRP, PRTN3, CD79A, IL1RAPL2
40glioblastoma multiforme30.4IL8
41peptic ulcer30.4IL8, S100A8
42tuberculosis30.3CCL4, IFNG, CRP, CD79A, IL10, IL7
43asthma30.3CCL4, CCL2, IFNG, S100A8, PRTN3, CD79A
44hypertension30.3CD79A, CRP, CCL2
45cystic fibrosis30.3IL8, PRTN3, S100A8
46infertility30.3CD79A
47crohn's disease30.3CRP
48systemic lupus erythematosus30.3CRP
49familial mediterranean fever30.3CRP
50neuropathy30.3CD79A

Graphical network of the top 20 diseases related to Relapsing Polychondritis:



Diseases related to relapsing polychondritis

Clinical Features for Relapsing Polychondritis

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 34)
  • renal glomerular defect/glomerulopathy
  • renal failure
  • proteinuria
  • hematuria/microhematuria
  • cranial nerves palsy
  • articular/joint pain/arthralgia
  • fever/chilling
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • gangrena/necrosis
  • arterial aneurism (excluding aorta)
  • arterial embolism/thrombosis
  • restricted joint mobility/joint stiffness/ankylosis
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • atelectasia/pulmonary collapse
  • cough
  • dizziness
  • arthritis/synovitis/synovial proliferation
  • vascularitis/vasculitides/arteritis
  • pinnae chondritis
  • nasal chondritis/nose chondritis
  • chronic uveitis/blepharitis/episcleritis/scleritis/conjonctivitis/keratitis
  • sensorineural deafness/hearing loss
  • endocardium anomalies/fibroelastosis/endocarditis
  • myocardium anomalies/myocarditis
  • respiratory rhythm disorder
  • laryngomalacia
  • hepatitis/icterus/cholestasis
  • alopecia
  • purpura/petichiae
  • enanthema/aphtosa/aphta/leukoplakia
  • macules
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cataract/lens opacification

Drugs & Therapeutics for Relapsing Polychondritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Relapsing Polychondritis

Drug clinical trials:

Search ClinicalTrials for Relapsing Polychondritis

Search NIH Clinical Center for Relapsing Polychondritis

Search CenterWatch for Relapsing Polychondritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Relapsing Polychondritis

About this section

Anatomical Context for Relapsing Polychondritis

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Relapsing Polychondritis:

32
Heart, Bone, Eye, Skin, Lung, Bone marrow, Myeloid, Trachea, Brain, Pituitary, Kidney, Thyroid, Prostate, Testes, Monocytes, T cells

Animal Models for Relapsing Polychondritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Relapsing Polychondritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053909.6COMP, COL2A1, MATN1
2MP:00053876.3COMP, COL2A1, CCL2, IFNG, CRP, PRTN3

Publications for Relapsing Polychondritis

About this section
Sources:
50PubMed
See all sources

Articles related to Relapsing Polychondritis:

(show top 50)    (show all 501)
idTitleAuthorsYear
1
Pathogenesis of relapsing polychondritis: a 2013 update. (24051104)
2014
2
Case of relapsing polychondritis showing elevation of anti-type II collagen antibody titer. (23855351)
2013
3
Clinical characteristics and treatment outcomes of patients with relapsing polychondritis with airway involvement. (23624590)
2013
4
From relapsing polychondritis to extracorporeal membrane oxygenation. (23993319)
2013
5
A case of saddle nose deformity caused by relapsing polychondritis: a long-term follow-up report after iliac bone grafting. (23759716)
2013
6
Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. (23404524)
2013
7
Recurrent anterior uveitis with hypopyon revealing relapsing polychondritis. (23154727)
2012
8
Surgical reconstruction of auricular relapsing polychondritis. (21629081)
2012
9
Relapsing polychondritis on PET/CT. (22876362)
2012
10
Case of recurrent Sweet's syndrome in a patient with relapsing polychondritis and myelodysplastic syndrome. (22077478)
2012
11
A case of relapsing polychondritis associated with auricular cartilage infiltration of immunoglobulin G4-positive plasma cells and lung cancer. (21547700)
2011
12
Relapsing polychondritis-associated refractory airway stenosis. (22045933)
2011
13
Keratouveitis as a first presentation of relapsing polychondritis. (21052558)
2010
14
Coexisting relapsing polychondritis and sarcoidosis: an unusual association. (19714334)
2010
15
Relapsing polychondritis following alopecia areata. (20672055)
2010
16
F-fluorodeoxyglucose positron emission tomography for relapsing polychondritis as a diagnostic approach and evaluation of disease activity. (21789107)
2009
17
The development of trigeminal neuralgia related to auricular chondritis in a patient with rheumatoid arthritis-relapsing polychondritis and its treatment with etanercept. Description of the first case. (19327242)
2009
18
Annular eruption preceding relapsing polychondritis: case report and review of the literature. (19335419)
2009
19
Crohn's disease, relapsing polychondritis and epidermolysis bullosa acquisita: an immune-mediated inflammatory syndrome. (18238795)
2008
20
Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis. (19119133)
2008
21
Relapsing polychondritis: a rare disease of multisystem involvement. (18094743)
2007
22
Relapsing polychondritis in North India: a report of 10 patients. (18092269)
2007
23
Relapsing polychondritis with features of dementia with Lewy bodies. (16832629)
2006
24
Otologic manifestations of relapsing polychondritis. Review of literature and report of nine cases. (16427754)
2006
25
Multiple cardiovascular involvement in a case of relapsing polychondritis. (17214281)
2006
26
A case of relapsing polychondritis preceded by inner ear involvement. (15882830)
2005
27
Syncope in a patient with relapsing polychondritis. (14644874)
2003
28
Relapsing polychondritis: commentary. (12563363)
2002
29
Relapsing polychondritis: a pediatric case. (11860574)
2002
30
Orbital mucosa-associated lymphoid tissue (MALT)-type lymphoma in a patient with relapsing polychondritis. (11465724)
2001
31
Serum level of macrophage migration inhibitory factor as a useful parameter of clinical course in patients with Wegener's granulomatosis and relapsing polychondritis. (11713914)
2001
32
Recurrent glomerulonephritis in relapsing polychondritis. (11244318)
2001
33
Diagnostic role of inspiration and expiration CT in a child with relapsing polychondritis. (11133539)
2001
34
A case of relapsing polychondritis with coronary ostial stenosis and severe aortic incompetence. (11071587)
2000
35
Relapsing polychondritis in childhood--case report and short review. (11063294)
2000
36
Testicular ischemia in a patient with relapsing polychondritis. Contribution of color flow Doppler to the diagnosis. (9670338)
1998
37
Relapsing polychondritis. (9699388)
1998
38
Recurrent aseptic purulent meningitis in a patient with relapsing polychondritis. (8838202)
1996
39
Steroid sparing effect of methotrexate in relapsing polychondritis. (8724312)
1996
40
Recurrent pneumonia in relapsing polychondritis. (7941542)
1994
41
Relapsing polychondritis responding to colchicine. (8056483)
1994
42
Myelodysplastic syndrome associated with relapsing polychondritis: unusual transformation from refractory anemia to chronic myelomonocytic leukemia. (8334199)
1993
43
Computed tomography of relapsing polychondritis. (8518993)
1993
44
Relapsing polychondritis presenting with stridor from bilateral vocal cord palsy. (1761956)
1991
45
Relapsing polychondritis. (2642680)
1989
46
Thymoma, myasthenia gravis, and relapsing polychondritis. (3382108)
1988
47
Relapsing polychondritis and cardiac valvular involvement. (3395043)
1988
48
Relapsing polychondritis. (3522446)
1986
49
Relapsing polychondritis studied by computed tomography. (4048461)
1985
50
Relapsing polychondritis. (4055328)
1985

Genetic Variations for Relapsing Polychondritis

About this section

Expression for genes affiliated with Relapsing Polychondritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Relapsing Polychondritis

Search GEO for disease gene expression data for Relapsing Polychondritis.

Pathways for genes affiliated with Relapsing Polychondritis

About this section
Sources:
51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 29KEGG, 52R&D Systems
See all sources

Compounds for genes affiliated with Relapsing Polychondritis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show top 50)    (show all 141)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.2COL2A1, IL1RAPL2
2cyclophosphamide44 49 1112.1CRP, IL7, APOH
3endotoxin4410.1S100A8, APOH
4gm-csf44 2810.8IL10, IFNG
5amphotericin b449.7CCL4, IL1RAPL2
6cyclosporin a44 28 5911.6IFNG, CD79A, IL1RAPL2
7azithromycin44 1110.6CD79A, CRP, IL10, IL8
8alpha-galactosylceramide449.4IFNG, CD1D, IL10, IL7
9allergens449.4IL10, CCL4, IL7, IFNG
10toxin-1449.4CCL2, IL8, IL10, CCL4
11okt3449.4IL7, CD79A, CRP, IFNG, IL10
128-isoprostane449.4IL8, CCL2, APOH, IL10, CRP
13polymyxin b449.4CCL2, IFNG, IL10, IL8
14mcp 1449.4IL8, CCL2, CCL4, IL10
15alginate449.3COMP, MATN1, COL2A1, CD79A
16mip 1alpha449.3IL8, IL10, CCL4, CCL2
17p00001449.3COMP, S100A8, IL1RAPL2
18il-12449.3IL7, IL8, IL10, IFNG, CCL2
19imiquimod44 28 59 1112.2IL8, IL10, IFNG, IL1RAPL2
20sulfasalazine44 28 49 1112.2CD79A, CRP, IL8, CCL2, IL1RAPL2
21superoxide44 2410.2IL1RAPL2, CCL2, CCL4, APOH
22lipoteichoic acid449.2IL10, IL8, CCL2, APOH
23groalpha449.1IL10, IL8, CCL4, CCL2
24triptolide449.0IL8, IFNG, CCL2, CCL4
25dexamethasone44 49 28 1112.0S100A8, IL7, CD79A, COL2A1, IL1RAPL2
26tarc449.0CCL4, IL10, IFNG, CCL2, IL8
27ccl344 2810.0IL8, IL10, CCL2, IFNG, CCL4
28adalimumab44 49 1110.9COMP, CRP, IFNG, CD79A, IL10, IL1RAPL2
29prednisolone44 28 1110.8CD79A, COMP, IL1RAPL2, APOH, CCL4, CRP
30rituximab44 49 1110.8CD79A, PRTN3, APOH, IL10, CRP
31glycosaminoglycan448.8COMP, COL2A1, CCL4, MATN1, IL1RAPL2
32neopterin448.8CRP, CD79A, IL10, IL1RAPL2, IFNG, IL8
33azathioprine44 49 2 1111.8CRP, CD79A, IL10, APOH, PRTN3
34rantes448.6IL1RAPL2, IL7, S100A8, IFNG, CCL4
35etanercept44 49 1110.6IL8, IL1RAPL2, IL10, CRP, APOH, IFNG
36sb 20358044 599.4CCL2, IFNG, CRP, IL10, IL8, CCL4
37methotrexate44 49 1110.4IL1RAPL2, S100A8, IL10, CRP, APOH, CD79A
38ivig448.3CD79A, CCL4, IFNG, IL10, APOH, CRP
39fibrinogen448.3IL1RAPL2, IL7, CD79A, CRP, APOH, CCL2
40il 10448.3IL1RAPL2, IL7, IL10, IFNG, CCL2, CCL4
41simvastatin44 49 59 28 11 2413.2IL1RAPL2, IL8, CCL4, IL10, CRP, IFNG
42infliximab44 49 1110.1CRP, PRTN3, IL10, IL1RAPL2, APOH, IFNG
43oxygen44 249.0PRTN3, CCL2, COL2A1, IL8, IL1RAPL2, S100A8
44creatinine447.9CD79A, S100A8, APOH, CRP, CCL4, IL1RAPL2
45vegf447.5CCL4, CD79A, CRP, IL8, APOH, IFNG
46histamine44 28 249.4CCL2, IL7, IL8, S100A8, IL10, CD79A
47lipid447.2IL7, CD1D, PRTN3, CRP, COMP, COL2A1
48nitric oxide44 11 248.8S100A8, COL2A1, CCL4, CCL2, IFNG, APOH
49calcium44 49 11 249.3CRP, PRTN3, IL1RAPL2, IL7, S100A8, CCL4
50retinoic acid44 247.2COMP, IFNG, S100A8, PRTN3, CCL4, COL2A1

GO Terms for genes affiliated with Relapsing Polychondritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.0COL2A1, CCL4, CCL2, IFNG, S100A8, CRP
2extracellular spaceGO:0056156.5IL8, COMP, COL2A1, CCL4, CCL2, IFNG

Biological processes related to Relapsing Polychondritis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.0IFNG, IL10
2response to molecule of bacterial originGO:00223710.0IL10, IL8
3regulation of gene expressionGO:0104689.9IL7, IL10, COL2A1
4humoral immune responseGO:0069599.8IL7, IFNG, CCL2
5organ morphogenesisGO:0098879.8COMP, CCL2, IL7
6B cell proliferationGO:0421009.8CD79A, IL10
7negative regulation of growth of symbiont in hostGO:0441309.8IL10, IFNG
8endoplasmic reticulum unfolded protein responseGO:0309689.6IL8, IFNG, CCL2
9response to ethanolGO:0454719.4CRP, S100A8, CCL2
10cellular response to lipopolysaccharideGO:0712229.4CCL2, IFNG, IL10, IL8
11cellular component movementGO:0069289.3IL8, IFNG, CCL4
12neutrophil chemotaxisGO:0305939.1IL8, S100A8, IFNG, CCL2
13defense response to bacteriumGO:0427428.8IL10, S100A8, IFNG
14inflammatory responseGO:0069548.4CCL4, CCL2, S100A8, CRP, IL10, IL8

Molecular functions related to Relapsing Polychondritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.3IL8, CCL2, CCL4
2cytokine activityGO:0051258.7IL7, IL10, IFNG, CCL4

Products for genes affiliated with Relapsing Polychondritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Relapsing Polychondritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet