MCID: RMS001
MIFTS: 42

Rem Sleep Behavior Disorder malady

Mental diseases category

Summaries for Rem Sleep Behavior Disorder

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to parkinson's disease and dementia. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds atropine and 1-benzyl-1,2,3,4-tetrahydroisoquinoline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Wikipedia:66 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Aliases & Classifications for Rem Sleep Behavior Disorder

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


Aliases & Descriptions:

rem sleep behavior disorder 9 46 63
rapid eye movement sleep behavior disorder 9


External Ids:

Disease Ontology9 DOID:9091
MeSH36 D020187
SNOMED-CT59 415238003
ICD9CM28 327.42

Related Diseases for Rem Sleep Behavior Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.6SLC6A3, RPS27A, SNCA
2dementia31.2SNCA, ACHE, SLC6A3, RPS27A
3progressive supranuclear palsy30.8SLC6A3
4tauopathy30.7SNCA, RPS27A
5alzheimer's disease30.7SLC6A3, RPS27A, SNCA, ACHE
6multiple system atrophy30.6RPS27A, SLC6A3, SNCA
7pure autonomic failure30.5ACHE, SNCA
8lewy body dementia30.5SLC6A3, SNCA
9memory impairment30.4SNCA, SLC6A3, ACHE
10frontotemporal dementia30.4ACHE, RPS27A, SNCA
11narcolepsy10.8
12sleep apnea10.7
13obstructive sleep apnea10.6
14bruxism10.6
15limbic encephalitis10.6
16multiple sclerosis10.5
17sleep disorder10.5
18machado-joseph disease10.5
19hypersomnia10.4
20myoclonus10.4
21obsessive-compulsive disorder10.3
22alexithymia10.3
23cerebritis10.3
24restless legs syndrome10.3
25arthritis10.3
26encephalitis10.3
27leukodystrophy10.3
28pancreatitis10.3
29rheumatoid arthritis10.3
30neurologic diseases10.3
31chiari malformation10.3
32corticobasal degeneration10.3
33autonomic dysfunction10.3
34neuronal intranuclear inclusion disease10.1RPS27A
35essential tremor10.0SNCA, SLC6A3
36neurilemmoma10.0ACHE, SNCA
37cerebrovascular disease10.0SLC6A3, ACHE
38psychotic disorder10.0SLC6A3, ACHE
39down syndrome10.0SNCA, ACHE
40neuroaxonal dystrophy10.0RPS27A, SNCA
41creutzfeldt-jakob disease10.0SNCA, RPS27A
42spinocerebellar ataxia10.0RPS27A, SNCA
43amyloid tumor10.0RPS27A, ACHE
44motor neuron disease10.0RPS27A, SNCA
45alcohol abuse10.0RPS27A, SLC6A3
46pheochromocytoma10.0SLC6A3, SNCA
47epilepsy syndrome10.0ACHE, SLC6A3
48myositis10.0SNCA, RPS27A
49amyloidosis10.0SNCA, RPS27A
50brain cancer10.0ACHE, SNCA

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Symptoms for Rem Sleep Behavior Disorder

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Drugs & Therapeutics for Rem Sleep Behavior Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Rem Sleep Behavior Disorder

Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Search CenterWatch for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

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Anatomical Context for Rem Sleep Behavior Disorder

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Sources:
34MalaCards
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MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

34
Eye, Brain, Testes, Heart

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

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Sources:
53PubMed
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Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 268)
idTitleAuthorsYear
1
From bench to bed: putative animal models of REM sleep behavior disorder (RBD). (23338670)
2013
2
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. (22989561)
2013
3
Characteristics of REM sleep behavior disorder in childhood. (22505856)
2012
4
I+-Synuclein and anti-I+-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. (23284971)
2012
5
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. (22744670)
2012
6
Challenging the myth of REM sleep behavior disorder: no evidence of heightened aggressiveness in dreams. (22503942)
2012
7
A motor signature of REM sleep behavior disorder. (22173891)
2012
8
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it? (22136900)
2011
9
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
10
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
11
Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (21538520)
2011
12
Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. (22205591)
2011
13
Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD? (22136899)
2011
14
Automatic REM sleep detection associated with idiopathic rem sleep Behavior Disorder. (22255722)
2011
15
REM sleep behavior disorder in psychiatric populations. (20797385)
2010
16
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. (20629146)
2010
17
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. (19968708)
2010
18
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
19
Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. (20097595)
2010
20
Video-clinical corners. Snoring, penile erection and loss of reflexive consciousness during REM sleep behavior disorder. (20817552)
2010
21
Three-year follow-up on the accumulation of cardiac (123)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (19307152)
2009
22
The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. (18359665)
2009
23
Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. (19204265)
2009
24
A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). (19345142)
2009
25
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
26
Subclinical REM sleep behavior disorder and its clinical and research implications. (19090317)
2008
27
Video analysis of motor events in REM sleep behavior disorder. (17516467)
2007
28
REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis. (17580598)
2007
29
Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. (17702272)
2007
30
Relationship between visual hallucinations and REM sleep behavior disorder in patients with Parkinson's disease. (17913346)
2007
31
Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (17230453)
2007
32
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
33
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
34
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (17101893)
2006
35
REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. (16228998)
2006
36
Update on the pharmacology of REM sleep behavior disorder. (16966533)
2006
37
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. (16217051)
2005
38
A case of marital discord and secondary depression with attempted suicide resulting from REM sleep behavior disorder in a 35-year-old woman. (15033135)
2004
39
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. (11902423)
2002
40
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
41
Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder. (12489892)
2002
42
Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. (12405541)
2002
43
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
44
Treatment of REM sleep behavior disorder with donepezil: a report of three cases. (10994012)
2000
45
Presumed REM sleep behavior disorder arising from cataplexy and wakeful dreaming. (10767654)
2000
46
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. (10646174)
1999
47
REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. (9710004)
1998
48
REM sleep behavior disorder. (8114229)
1994
49
Carbamazepine in REM sleep behavior disorder. (8456232)
1993
50
Polysomnographic features of REM sleep behavior disorder: development of a scoring method. (1620348)
1992

Variations for Rem Sleep Behavior Disorder

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Expression for genes affiliated with Rem Sleep Behavior Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters, 31KEGG, 54QIAGEN
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Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SLC6A3, SNCA
29.3SLC6A3, SNCA
3
Show member pathways
Serotonin Transporter Activity39
9.3SLC6A3, ACHE
4
Show member pathways
Proteasome Degradation39
Immune response Antigen presentation by MHC class I61
8.5SLC6A3, RPS27A, SNCA

Compounds for genes affiliated with Rem Sleep Behavior Disorder

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 25HMDB, 62Tocris Bioscience
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Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1atropine46 30 1211.8SNCA, ACHE
21-benzyl-1,2,3,4-tetrahydroisoquinoline469.7SLC6A3, SNCA
3ephedrine46 30 1211.7SLC6A3, ACHE
4piperidine469.7SLC6A3, ACHE
51 methyl 4 phenylpyridinium469.7SLC6A3, SNCA
6apomorphine30 46 1211.7SLC6A3, SNCA
7amphetamine46 52 1211.7SNCA, SLC6A3
8carbachol46 30 1211.5ACHE, SNCA
9thioflavine s469.5RPS27A, SNCA
10cocaine46 1210.5SLC6A3, SNCA
11formate469.5RPS27A, SNCA
12guanidine hydrochloride469.4SNCA, RPS27A
134-hydroxynonenal46 2510.4SNCA, RPS27A
14silver469.4SNCA, RPS27A
15geldanamycin46 52 62 1212.4SNCA, RPS27A
16lactacystin469.4RPS27A, SNCA
17sodium dodecylsulfate469.4RPS27A, SNCA
18selegiline46 1210.2SLC6A3, SNCA, ACHE
19biotin46 25 1211.2RPS27A, SLC6A3
20nicotine46 30 52 1212.2ACHE, SLC6A3
21mg 13246 6210.2RPS27A, SNCA
22choline46 25 1211.2SLC6A3, SNCA, ACHE
23carbon469.0SLC6A3, RPS27A
24gaba469.0SLC6A3, RPS27A
25rotenone468.9SNCA, RPS27A, SLC6A3
26methamphetamine46 52 1210.9SLC6A3, RPS27A, SNCA
276-hydroxydopamine468.9SNCA, RPS27A, SLC6A3
28mptp468.9SLC6A3, RPS27A, SNCA
29levodopa46 129.9SNCA, RPS27A, SLC6A3
30valine468.9SNCA, RPS27A, SLC6A3
31nmda46 309.9ACHE, RPS27A, SLC6A3
32h2o2468.8SNCA, RPS27A, SLC6A3
33tacrolimus46 52 1210.8RPS27A, SNCA
34arginine468.8SLC6A3, RPS27A, SNCA
35alanine468.8SLC6A3, RPS27A, SNCA
36cysteine468.7SLC6A3, RPS27A, SNCA
37acetylcholine46 52 30 25 1212.4SLC6A3, RPS27A, SNCA, ACHE
38dopamine46 30 25 1211.4ACHE, SNCA, RPS27A, SLC6A3
39glutamate468.4ACHE, SNCA, RPS27A, SLC6A3
40serine468.3ACHE, SNCA, RPS27A, SLC6A3

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

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17Gene Ontology
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Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.5SLC6A3, SNCA, ACHE
2plasma membraneGO:0058868.0SLC6A3, RPS27A, SNCA, ACHE

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid metabolic processGO:0066449.4SNCA, ACHE
2dopamine biosynthetic processGO:0424169.4SLC6A3, SNCA
3receptor internalizationGO:0316239.3ACHE, SNCA
4neurotransmitter biosynthetic processGO:0421369.3SLC6A3, ACHE
5agingGO:0075689.0SLC6A3, SNCA

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

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  • Antibodies
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Sources for Rem Sleep Behavior Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet