MCID: RMS001
MIFTS: 43

Rem Sleep Behavior Disorder malady

Mental diseases category
Download this MalaCard

Summaries for Rem Sleep Behavior Disorder

About this section


Fully expand this MalaCard
Disease Ontology:8 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to parkinson's disease and progressive supranuclear palsy. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds atropine and 1-benzyl-1,2,3,4-tetrahydroisoquinoline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Wikipedia:65 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Aliases & Classifications for Rem Sleep Behavior Disorder

About this section
Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Rem Sleep Behavior Disorder, Aliases & Descriptions:

Name: Rem Sleep Behavior Disorder 8 44 62
 
Rapid Eye Movement Sleep Behavior Disorder 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:9091
MeSH34 D020187
SNOMED-CT57 415238003
ICD9CM27 327.42

Related Diseases for Rem Sleep Behavior Disorder

About this section

Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.4SLC6A3, RPS27A, SNCA
2progressive supranuclear palsy31.3SLC6A3
3dementia30.8SNCA, ACHE, SLC6A3, RPS27A
4pure autonomic failure30.7ACHE, SNCA
5tauopathy30.7SNCA, RPS27A
6lewy body dementia30.6SLC6A3, SNCA
7machado-joseph disease30.6SLC6A3, SNCA, RPS27A
8multiple system atrophy30.4RPS27A, SLC6A3, SNCA
9memory impairment30.3SNCA, SLC6A3, ACHE
10frontotemporal dementia30.2ACHE, RPS27A, SNCA
11alzheimer's disease30.2SLC6A3, RPS27A, SNCA, ACHE
12narcolepsy10.8
13sleep apnea10.7
14synucleinopathy10.7
15obstructive sleep apnea10.7
16bruxism10.6
17limbic encephalitis10.6
18multiple sclerosis10.6
19sleep disorder10.6
20arthritis10.5
21rheumatoid arthritis10.5
22corticobasal degeneration10.5
23hypersomnia10.4
24myoclonus10.4
25restless legs syndrome10.3
26obsessive-compulsive disorder10.3
27alexithymia10.3
28cerebritis10.3
29encephalitis10.3
30impulse control disorder10.3
31leukodystrophy10.3
32pancreatitis10.3
33neurologic diseases10.3
34chiari malformation10.3
35autonomic dysfunction10.3
36neuronal intranuclear inclusion disease10.3RPS27A
37essential tremor10.1SNCA, SLC6A3
38neurilemmoma10.1ACHE, SNCA
39cerebrovascular disease10.1SLC6A3, ACHE
40psychotic disorder10.1SLC6A3, ACHE
41down syndrome10.0SNCA, ACHE
42neuroaxonal dystrophy10.0RPS27A, SNCA
43creutzfeldt-jakob disease10.0SNCA, RPS27A
44spinocerebellar ataxia10.0RPS27A, SNCA
45amyloid tumor10.0RPS27A, ACHE
46motor neuron disease10.0RPS27A, SNCA
47alcohol abuse10.0RPS27A, SLC6A3
48pheochromocytoma10.0SLC6A3, SNCA
49epilepsy syndrome10.0ACHE, SLC6A3
50myositis9.9SNCA, RPS27A

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Symptoms for Rem Sleep Behavior Disorder

About this section

Drugs & Therapeutics for Rem Sleep Behavior Disorder

About this section

Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

About this section

Anatomical Context for Rem Sleep Behavior Disorder

About this section

MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

32
Eye, Brain, Testes, Heart, Pons

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

About this section

MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

About this section

Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 292)
idTitleAuthorsYear
1
Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China. (24938584)
2014
2
Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. (24758223)
2014
3
Antidepressants trigger an early clinical presentation of REM sleep behavior disorder: the jury is still out. (25083020)
2014
4
From bench to bed: putative animal models of REM sleep behavior disorder (RBD). (23338670)
2013
5
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. (22989561)
2013
6
Characteristics of REM sleep behavior disorder in childhood. (22505856)
2012
7
I+-Synuclein and anti-I+-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. (23284971)
2012
8
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. (22744670)
2012
9
Challenging the myth of REM sleep behavior disorder: no evidence of heightened aggressiveness in dreams. (22503942)
2012
10
A motor signature of REM sleep behavior disorder. (22173891)
2012
11
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it? (22136900)
2011
12
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
13
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
14
Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (21538520)
2011
15
Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. (22205591)
2011
16
Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD? (22136899)
2011
17
Automatic REM sleep detection associated with idiopathic rem sleep Behavior Disorder. (22255722)
2011
18
REM sleep behavior disorder in psychiatric populations. (20797385)
2010
19
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. (20629146)
2010
20
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. (19968708)
2010
21
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
22
Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. (20097595)
2010
23
Video-clinical corners. Snoring, penile erection and loss of reflexive consciousness during REM sleep behavior disorder. (20817552)
2010
24
Three-year follow-up on the accumulation of cardiac (123)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (19307152)
2009
25
The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. (18359665)
2009
26
Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. (19204265)
2009
27
A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). (19345142)
2009
28
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
29
Video analysis of motor events in REM sleep behavior disorder. (17516467)
2007
30
REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis. (17580598)
2007
31
Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. (17702272)
2007
32
Relationship between visual hallucinations and REM sleep behavior disorder in patients with Parkinson's disease. (17913346)
2007
33
Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (17230453)
2007
34
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
35
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
36
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (17101893)
2006
37
REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. (16228998)
2006
38
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. (16217051)
2005
39
A case of marital discord and secondary depression with attempted suicide resulting from REM sleep behavior disorder in a 35-year-old woman. (15033135)
2004
40
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. (11902423)
2002
41
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
42
Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder. (12489892)
2002
43
Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. (12405541)
2002
44
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
45
Treatment of REM sleep behavior disorder with donepezil: a report of three cases. (10994012)
2000
46
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. (10646174)
1999
47
REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. (9710004)
1998
48
REM sleep behavior disorder. (8114229)
1994
49
Carbamazepine in REM sleep behavior disorder. (8456232)
1993
50
Polysomnographic features of REM sleep behavior disorder: development of a scoring method. (1620348)
1992

Variations for Rem Sleep Behavior Disorder

About this section

Expression for genes affiliated with Rem Sleep Behavior Disorder

About this section
Expression patterns in normal tissues for genes affiliated with Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

About this section

Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SLC6A3, SNCA
29.3SLC6A3, SNCA
3
Show member pathways
Serotonin Transporter Activity37
9.3SLC6A3, ACHE
4
Show member pathways
Proteasome Degradation37
Immune response Antigen presentation by MHC class I60
8.5SLC6A3, RPS27A, SNCA

Compounds for genes affiliated with Rem Sleep Behavior Disorder

About this section

Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1atropine44 28 1111.8SNCA, ACHE
21-benzyl-1,2,3,4-tetrahydroisoquinoline449.7SLC6A3, SNCA
3ephedrine44 28 1111.7SLC6A3, ACHE
4piperidine449.7SLC6A3, ACHE
51 methyl 4 phenylpyridinium449.7SLC6A3, SNCA
6apomorphine28 44 1111.7SLC6A3, SNCA
7amphetamine44 50 1111.7SNCA, SLC6A3
8carbachol44 28 1111.5ACHE, SNCA
9thioflavine s449.5RPS27A, SNCA
10cocaine44 1110.5SLC6A3, SNCA
11formate449.5RPS27A, SNCA
12guanidine hydrochloride449.4SNCA, RPS27A
134-hydroxynonenal44 2410.4SNCA, RPS27A
14silver449.4SNCA, RPS27A
15geldanamycin44 50 61 1112.4SNCA, RPS27A
16lactacystin449.4RPS27A, SNCA
17sodium dodecylsulfate449.4RPS27A, SNCA
18selegiline44 1110.2SLC6A3, SNCA, ACHE
19biotin44 24 1111.2RPS27A, SLC6A3
20nicotine44 28 50 1112.2ACHE, SLC6A3
21mg 13244 6110.2RPS27A, SNCA
22choline44 24 1111.2SLC6A3, SNCA, ACHE
23carbon449.0SLC6A3, RPS27A
24gaba449.0SLC6A3, RPS27A
25rotenone448.9SNCA, RPS27A, SLC6A3
26methamphetamine44 50 1110.9SLC6A3, RPS27A, SNCA
276-hydroxydopamine448.9SNCA, RPS27A, SLC6A3
28mptp448.9SLC6A3, RPS27A, SNCA
29levodopa44 119.9SNCA, RPS27A, SLC6A3
30valine448.9SNCA, RPS27A, SLC6A3
31nmda44 289.9ACHE, RPS27A, SLC6A3
32h2o2448.8SNCA, RPS27A, SLC6A3
33tacrolimus44 50 1110.8RPS27A, SNCA
34arginine448.8SLC6A3, RPS27A, SNCA
35alanine448.8SLC6A3, RPS27A, SNCA
36cysteine448.7SLC6A3, RPS27A, SNCA
37acetylcholine44 50 28 24 1112.4SLC6A3, RPS27A, SNCA, ACHE
38dopamine44 28 24 1111.4ACHE, SNCA, RPS27A, SLC6A3
39glutamate448.4ACHE, SNCA, RPS27A, SLC6A3
40serine448.3ACHE, SNCA, RPS27A, SLC6A3

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

About this section

Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.5SLC6A3, SNCA, ACHE
2plasma membraneGO:0058868.0SLC6A3, RPS27A, SNCA, ACHE

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid metabolic processGO:0066449.4SNCA, ACHE
2dopamine biosynthetic processGO:0424169.4SLC6A3, SNCA
3receptor internalizationGO:0316239.3ACHE, SNCA
4neurotransmitter biosynthetic processGO:0421369.3SLC6A3, ACHE
5agingGO:0075689.0SLC6A3, SNCA

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Rem Sleep Behavior Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet