Rem Sleep Behavior Disorder malady

Disease Ontology: A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.⁶

MalaCards: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to spinocerebellar ataxia type 3 and alzheimer's disease. An important gene associated with Rem Sleep Behavior Disorder is SLC6A3 (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3), and among its related pathways are Parkinsons disease and Parkinsons Disease Pathway. The compounds ephedrine and piperidine have been mentioned in the context of this disorder. Related mouse phenotype taste/olfaction.

Wikipedia: Rapid eye movement sleep behaviour disorder (RBD) is a sleep disorder (more specifically a parasomnia)...⁴⁴ more...

Aliases & Descriptions:

rem sleep behavior disorder 6 32 43 rapid eye movement sleep behavior disorder 6

rem sleep behavior disease 8

Diseases related to rem sleep behavior disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 68)

id	Related Disease	Score	Top Affiliating Genes
1	spinocerebellar ataxia type 3	31.1	SLC6A3, RPS27A, SNCA
2	alzheimer's disease	30.0	SLC6A3, ACHE, SNCA, RPS27A
3	parkinson's disease	28.9	SLC6A3, SNCA, RPS27A, ACHE
4	cocaine dependence	12.8	SLC6A3, ACHE
5	ppm-x syndrome	12.8	ACHE, SLC6A3
6	orthostatic hypotension	12.8	SNCA, ACHE
7	phenylketonuria	12.8	ACHE, SLC6A3
8	tardive dyskinesia	12.7	SLC6A3, ACHE
9	cocaine abuse	12.7	SNCA, SLC6A3
10	restless legs syndrome	12.7	SNCA, SLC6A3
11	essential tremor	12.7	SLC6A3, SNCA
12	neurilemmoma	12.7	SNCA, ACHE
13	drug dependence	12.7	SNCA, SLC6A3
14	amyloid tumor	12.5	RPS27A, ACHE
15	alcoholism	12.5	SLC6A3, SNCA
16	chorea	12.5	ACHE, RPS27A
17	neuronal intranuclear inclusion disease	12.5	SNCA, RPS27A
18	neuroaxonal dystrophy	12.5	SNCA, RPS27A
19	corticobasal degeneration	12.5	RPS27A, SNCA
20	inclusion body myopathy	12.5	RPS27A, SNCA
21	creutzfeldt-jakob syndrome	12.5	SNCA, RPS27A
22	olivopontocerebellar atrophy	12.4	RPS27A, SNCA
23	lymphopenia	12.4	RPS27A, ACHE
24	hydrocephalus	12.4	ACHE, SLC6A3
25	aphasia	12.4	SNCA, RPS27A
26	alcohol abuse	12.4	SLC6A3, RPS27A
27	autonomic dysfunction	12.4	RPS27A, SNCA
28	tremor	12.4	SLC6A3, SNCA
29	paget's disease of bone	12.4	RPS27A, SNCA
30	vascular dementia	12.3	ACHE, RPS27A
31	albinism	12.3	ACHE, SNCA
32	gliosis	12.3	SNCA, RPS27A
33	cognitive disease	12.3	SNCA, ACHE, SLC6A3
34	memory impairment	12.3	ACHE, SLC6A3, SNCA
35	tauopathy	12.3	SNCA, RPS27A
36	inclusion body myositis	12.3	RPS27A, SNCA
37	alcohol dependence	12.2	ACHE, SLC6A3, SNCA
38	anorexia nervosa	12.2	SLC6A3, SNCA, ACHE
39	differentiating neuroblastoma	12.2	RPS27A, SNCA
40	motor neuron disease	12.1	SNCA, RPS27A
41	cerebrovascular disease	12.1	SLC6A3, ACHE
42	oculomotor apraxia cogan type	12.0	SLC6A3, RPS27A, ACHE
43	striatonigral degeneration	12.0	SLC6A3, RPS27A, SNCA
44	movement disease	12.0	SLC6A3, RPS27A, SNCA
45	pick's disease	12.0	SNCA, RPS27A, ACHE
46	frontotemporal dementia	12.0	RPS27A, ACHE, SNCA
47	multiple system atrophy	12.0	SNCA, SLC6A3, RPS27A
48	paralysis	12.0	SNCA, RPS27A, ACHE
49	down syndrome	11.8	SNCA, RPS27A, ACHE
50	myopathy	11.7	RPS27A, ACHE, SNCA

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to rem sleep behavior disorder:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.3	SNCA, SLC6A3

Articles related to rem sleep behavior disorder:

id	Title	Authors	Year	Affiliating Genes
1	REM sleep behavior disorder preceding other aspects o f synucleinopathies by up to half a century. (20668263)	Claassen D.O.... Boeve B.F.	2010	SNCA
2	Rivastigmine-induced REM sleep behavior disorder (RBD ) in a 88-year-old man with Alzheimer's disease. (20411699)	Yeh S.B.... Schenck C.H.	2010	ACHE
3	Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder. (12777684)	Lai Y.Y.... Siegel J.M.	2003	SNCA
4	Increased muscle activity during rapid eye movement sleep correlates with decrease of striatal presynaptic dopamine transporters. IPT and IBZM SPECT imaging in subclinical and clinically manifest idiopathic REM sleep behavior disorder, Parkinson's disease, and controls. (12938802)	Eisensehr I.... Noachtar S.	2003	SLC6A3
5	Lewy body variant of Alzheimer's disease (AD) identif ied by postmortem ubiquitin staining in a previously reported case of AD associ ated with REM sleep behavior disorder. (9285091)	Schenck C.H.... Parisi J.E.	1997	RPS27A

Genes related to rem sleep behavior disorder according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.1	Publications
2	SNCA	synuclein, alpha (non A4 component of amyloid precursor)	11.1	Publications
3	RPS27A	ribosomal protein S27a	11.0	Publications
4	ACHE	acetylcholinesterase	11.0	Publications

Pathways related to rem sleep behavior disorder according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Parkinsons disease20	9.3	SNCA, SLC6A3
2	Parkinsons Disease Pathway36	9.0	SNCA, SLC6A3

Compounds related to rem sleep behavior disorder according to GeneDecks:

(show all 34)

id	Compound	Score	Top Affiliating Genes
1	ephedrine32 9 9	11.8	ACHE, SLC6A3
2	piperidine32	9.8	SLC6A3, ACHE
3	1-benzyl-1,2,3,4-tetrahydroisoquinoline32	9.7	SNCA, SLC6A3
4	1 methyl 4 phenylpyridinium32	9.7	SNCA, SLC6A3
5	apomorphine32 9 9	11.6	SLC6A3, SNCA
6	amphetamine32 9 9	11.6	SNCA, SLC6A3
7	atropine32 9 9	11.6	SNCA, ACHE
8	thioflavine s32	9.4	RPS27A, SNCA
9	formate32	9.3	SNCA, RPS27A
10	guanidine hydrochloride32	9.3	SNCA, RPS27A
11	silver32	9.3	SNCA, RPS27A
12	cocaine32 9 9	11.2	SLC6A3, SNCA
13	4-hydroxynonenal32 18	10.2	SNCA, RPS27A
14	selegiline32 9 9	11.2	SNCA, ACHE, SLC6A3
15	geldanamycin32 9 9	11.2	RPS27A, SNCA
16	lactacystin32	9.2	SNCA, RPS27A
17	choline32 9 18 9	12.2	SLC6A3, ACHE, SNCA
18	biotin32 9 18 9	12.1	RPS27A, SLC6A3
19	sodium dodecylsulfate32	9.1	SNCA, RPS27A
20	carbachol32 9 9	11.0	SNCA, ACHE
21	mg 13232 42	10.0	SNCA, RPS27A
22	nmda32 42	9.9	RPS27A, ACHE, SLC6A3
23	methamphetamine32 9 9	10.9	SNCA, RPS27A, SLC6A3
24	rotenone32	8.9	SLC6A3, RPS27A, SNCA
25	6-hydroxydopamine32	8.9	SLC6A3, RPS27A, SNCA
26	mptp32	8.9	SNCA, RPS27A, SLC6A3
27	levodopa32 9 9	10.9	SNCA, RPS27A, SLC6A3
28	valine32	8.9	SNCA, RPS27A, SLC6A3
29	h2o232	8.8	SLC6A3, RPS27A, SNCA
30	arginine32	8.6	SLC6A3, RPS27A, SNCA
31	acetylcholine32 9 18 9	11.4	SLC6A3, ACHE, RPS27A, SNCA
32	dopamine32 9 18 9	11.4	SLC6A3, ACHE, RPS27A, SNCA
33	glutamate32	8.3	SNCA, RPS27A, ACHE, SLC6A3
34	serine32	8.3	SLC6A3, ACHE, RPS27A, SNCA

Cellular components related to rem sleep behavior disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	9.3	SNCA, SLC6A3
2	synapse	GO:045202	9.0	SNCA, ACHE

Biological processes related to rem sleep behavior disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	receptor internalization	GO:031623	9.3	SNCA, ACHE
2	dopamine biosynthetic process	GO:042416	9.2	SNCA, SLC6A3
3	neurotransmitter biosynthetic process	GO:042136	9.1	ACHE, SLC6A3