MCID: RMS001
MIFTS: 40

Rem Sleep Behavior Disorder

Categories: Mental diseases

Aliases & Classifications for Rem Sleep Behavior Disorder

MalaCards integrated aliases for Rem Sleep Behavior Disorder:

Name: Rem Sleep Behavior Disorder 12 52 42 14 69
Rapid Eye Movement Sleep Behavior Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9091
ICD10 33 G47.52
ICD9CM 35 327.42
MeSH 42 D020187
SNOMED-CT 64 415238003
UMLS 69 C0751772

Summaries for Rem Sleep Behavior Disorder

Disease Ontology : 12 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary : Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to machado-joseph disease and 13q12.3 microdeletion syndrome. An important gene associated with Rem Sleep Behavior Disorder is SNCA (Synuclein Alpha), and among its related pathways/superpathways are Neuroscience and Monoamine Transport. The drugs Histamine and Mianserin have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and heart, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 72 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Related Diseases for Rem Sleep Behavior Disorder

Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
id Related Disease Score Top Affiliating Genes
1 machado-joseph disease 11.5
2 13q12.3 microdeletion syndrome 10.6 LRRK2 SNCA
3 dementia 10.5
4 parkinson disease 10 10.5 LRRK2 SNCA
5 celiac disease 12 10.5 LRRK2 SNCA
6 sparc-related osteogenesis imperfecta 10.5 LRRK2 SNCA
7 microcephaly 18, primary, autosomal dominant 10.4 SLC6A3 SNCA
8 riedel's fibrosing thyroiditis 10.4 LRRK2 SNCA
9 waldenstroem's macroglobulinemia 10.4 LRRK2 SNCA
10 narcolepsy 10.4
11 piebald trait, kit-related 10.4 LRRK2 SNCA
12 sleep apnea 10.3
13 hyperekplexia, hereditary 1, autosomal dominant or recessive 10.3 RPS27A SNCA
14 basilar impression, primary 10.3 RPS27A SNCA
15 obstructive sleep apnea 10.3
16 synucleinopathy 10.3
17 ectodermal dysplasia 13, hair/tooth type 10.3 LRRK2 SNCA
18 corneal endothelial dystrophy, autosomal recessive 10.2 SNCA VPS13A
19 multiple system atrophy 10.2
20 subungual glomus tumor 10.2 HCRT SNCA
21 bladder hepatoid adenocarcinoma 10.2 SLC6A3 SNCA
22 pyogenic arthritis, pyoderma gangrenosum and acne 10.2 ACHE SNCA
23 sleep disorder 10.1
24 fastkd2-related infantile mitochondrial encephalomyopathy 10.1 LRRK2 SNCA
25 thyrotropin-releasing hormone deficiency 10.1 LRRK2 SLC6A3 SNCA
26 atrioventricular septal defect 5 10.1 HCRT SNCA
27 ganglioneuroma 10.1 LRRK2 SLC6A3 SNCA
28 mast syndrome 10.1 LRRK2 RPS27A SNCA
29 nosophobia 10.0 LRRK2 SNCA
30 proteus syndrome, somatic 10.0 RPS27A SLC6A3 SNCA
31 rheumatoid arthritis 10.0
32 arthritis 10.0
33 corticobasal degeneration 10.0
34 pure autonomic failure 10.0
35 autonomic dysfunction 10.0
36 hereditary spastic paraplegia 3a 10.0 SNCA VPS13A
37 myopathy, distal, with early respiratory failure, autosomal dominant 10.0 HCRT SLC6A3
38 ovarian cystadenocarcinoma 9.9 ACHE SLC6A3 SNCA
39 perry syndrome 9.9 HCRT SLC6A3 SNCA
40 alzheimer disease 9.8
41 obsessive-compulsive disorder 9.8
42 restless legs syndrome 9.8
43 alexithymia 9.8
44 leukodystrophy 9.8
45 impulse control disorder 9.8
46 melanoma 9.8
47 cerebritis 9.8
48 pancreatitis 9.8
49 periodic limb movement disorder 9.8
50 encephalitis 9.8

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to Rem Sleep Behavior Disorder

Symptoms & Phenotypes for Rem Sleep Behavior Disorder

MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.5 ACHE HCRT LRRK2 SLC17A5 SLC6A3 SNCA
2 nervous system MP:0003631 9.17 ACHE HCRT LRRK2 SLC17A5 SLC6A3 SNCA

Drugs & Therapeutics for Rem Sleep Behavior Disorder

Drugs for Rem Sleep Behavior Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
2
Mianserin Approved Phase 4 24219-97-4 4184
3
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 73-31-4 896
4
Iodine Investigational Phase 4 7553-56-2 807
5 Protective Agents Phase 4,Phase 3,Phase 2
6 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
7 Antioxidants Phase 4,Phase 2
8 Central Nervous System Depressants Phase 4,Phase 2
9 Adrenergic Agents Phase 4
10 Adrenergic alpha-Antagonists Phase 4
11 Adrenergic Antagonists Phase 4
12 Antidepressive Agents Phase 4
13 Antidepressive Agents, Second-Generation Phase 4
14 Histamine Antagonists Phase 4
15 Histamine H1 Antagonists Phase 4
16
Histamine Phosphate Phase 4 51-74-1 65513
17 Psychotropic Drugs Phase 4
18
Serotonin Phase 4 50-67-9 5202
19 Serotonin Agents Phase 4
20 Serotonin Antagonists Phase 4
21 Pharmaceutical Solutions Phase 4,Phase 2
22 cadexomer iodine Phase 4
23 Calamus Nutraceutical Phase 4
24
Acetylcholine Approved Phase 3 51-84-3 187
25
Rivastigmine Approved, Investigational Phase 3 123441-03-2 77991
26 Cholinergic Agents Phase 3,Phase 1,Phase 2
27 Cholinesterase Inhibitors Phase 3,Phase 1,Phase 2
28 Neuroprotective Agents Phase 3
29
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
30
Donepezil Approved Phase 1, Phase 2 120014-06-4 3152
31
Ethanol Approved Phase 2 64-17-5 702
32 Strawberry Approved, Nutraceutical Phase 2
33 Anticonvulsants Phase 2
34 GABA Agents Phase 2
35 GABA Modulators Phase 2
36 Nootropic Agents Phase 1, Phase 2
37 Anti-Anxiety Agents Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Antipsychotic Agents Phase 2
40
Dopamine Approved 51-61-6, 62-31-7 681
41
Levodopa Approved 59-92-7 6047
42 Dopamine Agents
43 Dopamine agonists
44 Antiparkinson Agents
45 Dihydroxyphenylalanine
46 insulin
47 Insulin, Globin Zinc

Interventional clinical trials:

(show all 36)

id Name Status NCT ID Phase Drugs
1 Study to Determine Whether Ramelteon Helps People With REM Sleep Behavior Disorder Completed NCT01401413 Phase 4 ramelteon;placebo
2 Effect of Slow-release Melatonin (Circadin®) Therapy on Idiopathic RBD: a Pilot Study Recruiting NCT02836743 Phase 4 Circadin;Placebo
3 Treatment of Sleep Disturbances in Trauma-affected Refugees Recruiting NCT02761161 Phase 4 Mianserin
4 DaTSCAN Imaging in Aging and Neurodegenerative Disease Enrolling by invitation NCT01453127 Phase 4 I-123 Ioflupane solution injection prior to SPECT scan (DaTscan)
5 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Enrolling by invitation NCT03258294 Phase 4 Melatonin(Circadin®);Placebo Oral Tablet
6 Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease Enrolling by invitation NCT02768077 Phase 4 Melatonin(Circadin®);Placebo
7 Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia Completed NCT00767091 Phase 3 rivastigmine;placebo
8 Effect of Clonazepam on REM Sleep Behavior Disorder in Patients With Parkinsonism Completed NCT02312908 Phase 2 Clonazepam;Placebo
9 The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism Completed NCT00695136 Phase 1, Phase 2 Donepezil hydrochloride
10 Study Evaluating Nelotanserin for Treatment of REM Sleep Behavior Disorder in Subjects With Dementia (DLB or PDD) Recruiting NCT02708186 Phase 2 Nelotanserin;Placebo
11 A Study of Tolerability and Efficacy of Cannabidiol on Tremor in Parkinson's Disease Recruiting NCT02818777 Phase 2 cannabidiol;placebo
12 Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder Enrolling by invitation NCT02871427 Phase 2 Nelotanserin
13 Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease Not yet recruiting NCT02789592 Phase 2 Melatonin PR;Clonazepam;Melatonin PR placebo;Clonazepam placebo
14 Understanding the Natural History of REM Sleep Behavior Disorder Unknown status NCT01674998
15 Gait and REM Sleep Behavior Disorder Unknown status NCT02554331
16 Exploring the Relationship Between Alpha-synucleinopathy Related Non-motor Symptom and Post-op. Delirium in Elderly Patients With Spine Surgery Unknown status NCT02550626
17 Brain Imaging in the Idiopathic REM Sleep Behavior Disorder (ALICE) Completed NCT03072940
18 MRI Study of Brain Activity in Healthy Adults and Individuals With Parkinsonism and Rapid Eye Movement Disorder. Completed NCT01547481
19 Cognitive Benefits of Treating Sleep Apnea in Parkinson's Disease Completed NCT00492115
20 Exploration of the Reward System by Functional MRI in Parkinson's Disease Patients With and Without REM Sleep Behavior Disorder Recruiting NCT02824341
21 Detecting Parkinson's Disease Through Speech Analysis Recruiting NCT03133611
22 Prospective Neuroimaging Investigation of Idiopathic REM Sleep Behavior Disorder Recruiting NCT02984137
23 RBD Longitudinal as Prognostic for PD Recruiting NCT00817726
24 Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease Recruiting NCT03288909
25 Exploration of the Mechanism of Movement Improvement During RBD in Parkinson's Disease Using NIRS Recruiting NCT03060239
26 Natural History Study of Synucleinopathies Recruiting NCT01799915
27 Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease Recruiting NCT02640339
28 Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease Recruiting NCT02305147
29 Identification of Predictors for Early Cognitive Decline in Men Recruiting NCT03290040
30 SudoScan as a Biomarker of Parkinson's Disease Active, not recruiting NCT02767037
31 Biomarkers of Risk of Parkinson Disease Active, not recruiting NCT00775853
32 Evolution of RBD in PD Not yet recruiting NCT03047408
33 Efficacy and Safety of Melatonin and Clonazepam for IRBD: Cross-over Study Not yet recruiting NCT03255642 Melatonin 2mg;ClonazePAM 0.5 MG
34 Sleep Disturbances and Biomarkers of Sarcopenic OBesity Not yet recruiting NCT03175601
35 Motor Control During Rapid Eye Movement (REM) Sleep Behaviour Disorder Terminated NCT01886131
36 Efficacy and Tolerability of Ramelteon in Patients With Rapid Eye Movement (REM) Behavior Disorder and Parkinsonism Terminated NCT00745030 Rozerem;Placebo

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Cochrane evidence based reviews: rem sleep behavior disorder

Genetic Tests for Rem Sleep Behavior Disorder

Anatomical Context for Rem Sleep Behavior Disorder

MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

39
Eye, Brain, Heart, Testes, Pons, Colon, Skin

Publications for Rem Sleep Behavior Disorder

Articles related to Rem Sleep Behavior Disorder:

(show top 50) (show all 383)
id Title Authors Year
1
REM Sleep Behavior Disorder and Cognitive Impairment in Parkinson's Disease. ( 28645156 )
2017
2
Alterations of awake EEG in idiopathic REM sleep behavior disorder without cognitive impairment. ( 27894921 )
2017
3
REM sleep behavior disorder, autonomic dysfunction and synuclein-related neurodegeneration: where do we stand? ( 28871332 )
2017
4
A patient with childhood-onset aggressive parasomnia diagnosed 50 years later with idiopathic REM sleep behavior disorder and a history of sleepwalking. ( 28709007 )
2017
5
FDG PET, dopamine transporter SPECT, and olfaction: Combining biomarkers in REM sleep behavior disorder. ( 28734065 )
2017
6
Clinical Overview of REM Sleep Behavior Disorder. ( 28837993 )
2017
7
Diagnostic REM sleep muscle activity thresholds in patients with idiopathic REM sleep behavior disorder with and without obstructive sleep apnea. ( 28449901 )
2017
8
Skin nerve phosphorylated I+-synuclein deposits in idiopathic REM sleep behavior disorder. ( 28468843 )
2017
9
Two polysomnographic features of REM sleep behavior disorder: Clinical variations insight for Parkinson's disease. ( 28923293 )
2017
10
REM sleep behavior disorder and obstructive sleep apnea: does one "evil" make the other less or more "evil"? ( 28754242 )
2017
11
The influence of sleep disordered breathing in REM sleep behavior disorder. ( 28673760 )
2017
12
Characterization of motor events in REM sleep behavior disorder. ( 28721577 )
2017
13
Melatonin Effects in REM Sleep Behavior Disorder Associated with Obstructive Sleep Apnea Syndrome: A case series. ( 28545360 )
2017
14
REM Sleep Behavior Disorder in Parkinson's Disease and Other Synucleinopathies. ( 28513079 )
2017
15
Characterization of patients with longstanding idiopathic REM sleep behavior disorder. ( 28615430 )
2017
16
REM Sleep Behavior Disorder Is Not Associated with a More Rapid Cognitive Decline in Mild Dementia. ( 28824532 )
2017
17
REM sleep behavior disorder is related to enteric neuropathology in Parkinson disease. ( 28887374 )
2017
18
REM Sleep EEG Instability in REM Sleep Behavior Disorder and Clonazepam Effects. ( 28482056 )
2017
19
Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder. ( 28472425 )
2017
20
Heart rate changes according to the complexity of motor events in REM sleep behavior disorder. ( 28558316 )
2017
21
Colonic Oxidative and Mitochondrial Function in Parkinson's Disease and Idiopathic REM Sleep Behavior Disorder. ( 28660090 )
2017
22
Periodic Limb Movements During Sleep Mimicking REM Sleep Behavior Disorder: A New Form of Periodic Limb Movement Disorder. ( 28364416 )
2017
23
The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder. ( 27131830 )
2016
24
Metabolic abnormality of pontine tegmentum in patients with REM sleep behavior disorder analyzed using magnetic resonance spectroscopy. ( 27448046 )
2016
25
Seeking Good Alternatives to Clonazepam: Suggestions for Future Treatment Trials in REM Sleep Behavior Disorder. ( 27448419 )
2016
26
Risk Factor Profile in Parkinson's Disease Subtype with REM Sleep Behavior Disorder. ( 26889635 )
2016
27
Prediction of later clinical course by a specific glucose metabolic pattern in non-demented patients with probable REM sleep behavior disorder admitted to a memory clinic: A case study. ( 26754469 )
2016
28
Caring burden of REM sleep behavior disorder - spouses' health and marital relationship. ( 27810184 )
2016
29
Increased Motor Activity During REM Sleep Is Linked with Dopamine Function in Idiopathic REM Sleep Behavior Disorder and Parkinson Disease. ( 27070245 )
2016
30
Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? ( 28082168 )
2016
31
The Evolution of REM Sleep Behavior Disorder in Early Parkinson Disease. ( 27306265 )
2016
32
Screening for REM sleep behavior disorder in the general population. ( 27697450 )
2016
33
National validation and proposed revision of REM sleep behavior disorder screening questionnaire (RBDSQ). ( 27671482 )
2016
34
Comparison between Automatic and Visual Scorings of REM Sleep without Atonia for the Diagnosis of REM Sleep Behavior Disorder in Parkinson Disease. ( 27923423 )
2016
35
Brain pathway differences between Parkinson's disease patients with and without REM sleep behavior disorder. ( 27853964 )
2016
36
Loss of REM sleep features across nighttime in REM sleep behavior disorder. ( 26847988 )
2016
37
Longitudinal changes in cognition in early Parkinson's disease patients with REM sleep behavior disorder. ( 27010070 )
2016
38
Periodic Limb Movements during Sleep Mimicking REM Sleep Behavior Disorder. ( 27923426 )
2016
39
A case series of REM sleep behavior disorder in pure autonomic failure. ( 27757562 )
2016
40
Many faces of REM sleep behavior disorder: an editorial. ( 26750738 )
2016
41
The combined effect of REM sleep behavior disorder and hyposmia on cognition and motor phenotype in Parkinson's disease. ( 27538667 )
2016
42
Severe Brain Metabolic Decreases Associated with REM Sleep Behavior Disorder in Dementia with Lewy Bodies. ( 27060952 )
2016
43
REM sleep behavior disorder was associated with Parkinson's disease: a community-based study. ( 27484952 )
2016
44
REM sleep behavior disorder and periodic leg movements during sleep in ALS. ( 27027974 )
2016
45
Effects of Rotigotine on REM Sleep Behavior Disorder in Parkinson Disease. ( 27568909 )
2016
46
Absence of LRRK2 mutations in a cohort of patients with idiopathic REM sleep behavior disorder. ( 26747879 )
2016
47
Brain imaging findings in idiopathic REM sleep behavior disorder (RBD) - A systematic review on potential biomarkers for neurodegeneration. ( 27542516 )
2016
48
Efficacy of sodium oxybate on REM sleep behavior disorder in a patient with narcolepsy type 1. ( 27807183 )
2016
49
Treatment of REM Sleep Behavior Disorder. ( 27752878 )
2016
50
Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones. ( 27081385 )
2016

Variations for Rem Sleep Behavior Disorder

Expression for Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for Rem Sleep Behavior Disorder

GO Terms for Rem Sleep Behavior Disorder

Cellular components related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.65 LRRK2 SLC6A3 SNCA
2 lysosome GO:0005764 9.61 LRRK2 SLC17A5 SNCA
3 cell junction GO:0030054 9.55 ACHE HCRT LRRK2 SLC17A5 SNCA
4 axon GO:0030424 9.54 LRRK2 SLC6A3 SNCA
5 synaptic vesicle membrane GO:0030672 9.49 LRRK2 SLC17A5
6 terminal bouton GO:0043195 9.46 LRRK2 SNCA
7 synaptic vesicle GO:0008021 9.43 HCRT LRRK2 SNCA
8 rough endoplasmic reticulum GO:0005791 9.4 HCRT SNCA
9 inclusion body GO:0016234 9.32 LRRK2 SNCA
10 postsynapse GO:0098794 9.13 HCRT LRRK2 SNCA
11 synapse GO:0045202 9.02 ACHE HCRT LRRK2 SLC17A5 SNCA

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of protein phosphorylation GO:0001933 9.49 LRRK2 SNCA
2 negative regulation of neuron death GO:1901215 9.48 LRRK2 SNCA
3 receptor internalization GO:0031623 9.46 ACHE SNCA
4 response to cocaine GO:0042220 9.43 SLC6A3 SNCA
5 regulation of neuron death GO:1901214 9.4 LRRK2 SNCA
6 regulation of neurotransmitter secretion GO:0046928 9.37 HCRT SNCA
7 neurotransmitter biosynthetic process GO:0042136 9.32 ACHE SLC6A3
8 dopamine biosynthetic process GO:0042416 9.26 SLC6A3 SNCA
9 regulation of locomotion GO:0040012 9.16 LRRK2 SNCA
10 dopamine uptake involved in synaptic transmission GO:0051583 8.96 SLC6A3 SNCA
11 excitatory postsynaptic potential GO:0060079 8.8 HCRT LRRK2 SNCA

Sources for Rem Sleep Behavior Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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