MCID: RMS001
MIFTS: 41

Rem Sleep Behavior Disorder malady

Summaries for Rem Sleep Behavior Disorder

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Disease Ontology:10 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to dementia and machado-joseph disease. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds atropine and 1-benzyl-1,2,3,4-tetrahydroisoquinoline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Aliases & Classifications for Rem Sleep Behavior Disorder

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 57SNOMED-CT, 29ICD9CM, 35MeSH
See all sources

Rem Sleep Behavior Disorder, Aliases & Descriptions:

Name: Rem Sleep Behavior Disorder 10 45 62
 
Rapid Eye Movement Sleep Behavior Disorder 10 62


External Ids:

Disease Ontology10 DOID:9091
ICD9CM29 327.42
SNOMED-CT57 415238003
MeSH35 D020187

Related Diseases for Rem Sleep Behavior Disorder

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Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.4SLC6A3, RPS27A, SNCA, ACHE
2machado-joseph disease30.9SNCA, RPS27A, SLC6A3
3multiple system atrophy30.8SNCA, RPS27A, SLC6A3
4tauopathy30.7SNCA, RPS27A
5pure autonomic failure30.5ACHE, SNCA
6alzheimer disease30.4SLC6A3, RPS27A, SNCA, ACHE
7narcolepsy10.8
8sleep apnea10.7
9synucleinopathy10.7
10obstructive sleep apnea10.7
11bruxism10.6
12limbic encephalitis10.6
13sleep disorder10.6
14rheumatoid arthritis10.5
15arthritis10.5
16corticobasal degeneration10.5
17hypersomnia10.4
18myoclonus10.4
19obsessive-compulsive disorder10.3
20alexithymia10.3
21cerebritis10.3
22restless legs syndrome10.3
23encephalitis10.3
24impulse control disorder10.3
25leukodystrophy10.3
26pancreatitis10.3
27neurologic diseases10.3
28chiari malformation10.3
29ataxia10.3
30autonomic dysfunction10.3
31supranuclear palsy, progressive10.0SLC6A3
32neuronal intranuclear inclusion disease10.0RPS27A
33essential tremor10.0SNCA, SLC6A3
34dementia, lewy body10.0SLC6A3, SNCA
35neurilemmoma10.0ACHE, SNCA
36cerebrovascular disease10.0SLC6A3, ACHE
37psychotic disorder10.0ACHE, SLC6A3
38neuroaxonal dystrophy10.0RPS27A, SNCA
39down syndrome10.0SNCA, ACHE
40alcohol dependence10.0SNCA, SLC6A3
41creutzfeldt-jakob disease10.0SNCA, RPS27A
42spinocerebellar ataxia10.0RPS27A, SNCA
43amyloid tumor10.0RPS27A, ACHE
44motor neuron disease10.0SNCA, RPS27A
45alcohol abuse10.0RPS27A, SLC6A3
46pheochromocytoma10.0SLC6A3, SNCA
47epilepsy syndrome10.0SLC6A3, ACHE
48myositis10.0RPS27A, SNCA
49amyloidosis10.0RPS27A, SNCA
50brain cancer10.0ACHE, SNCA

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Symptoms for Rem Sleep Behavior Disorder

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Drugs & Therapeutics for Rem Sleep Behavior Disorder

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Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

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Anatomical Context for Rem Sleep Behavior Disorder

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MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

33
Eye, Brain, Testes, Heart, Pons

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

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MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

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Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Parkinson disease with REM sleep behavior disorder: features, I+-synuclein, and inflammation. (25663225)
2015
2
Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China. (24938584)
2014
3
Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. (24758223)
2014
4
From bench to bed: putative animal models of REM sleep behavior disorder (RBD). (23338670)
2013
5
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. (22989561)
2013
6
Characteristics of REM sleep behavior disorder in childhood. (22505856)
2012
7
I+-Synuclein and anti-I+-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. (23284971)
2012
8
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. (22744670)
2012
9
Challenging the myth of REM sleep behavior disorder: no evidence of heightened aggressiveness in dreams. (22503942)
2012
10
A motor signature of REM sleep behavior disorder. (22173891)
2012
11
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it? (22136900)
2011
12
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
13
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
14
Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (21538520)
2011
15
Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. (22205591)
2011
16
Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD? (22136899)
2011
17
Automatic REM sleep detection associated with idiopathic rem sleep Behavior Disorder. (22255722)
2011
18
REM sleep behavior disorder in psychiatric populations. (20797385)
2010
19
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. (20629146)
2010
20
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. (19968708)
2010
21
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
22
Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. (20097595)
2010
23
Video-clinical corners. Snoring, penile erection and loss of reflexive consciousness during REM sleep behavior disorder. (20817552)
2010
24
Three-year follow-up on the accumulation of cardiac (123)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (19307152)
2009
25
The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. (18359665)
2009
26
Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. (19204265)
2009
27
A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). (19345142)
2009
28
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
29
Video analysis of motor events in REM sleep behavior disorder. (17516467)
2007
30
REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis. (17580598)
2007
31
Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. (17702272)
2007
32
Relationship between visual hallucinations and REM sleep behavior disorder in patients with Parkinson's disease. (17913346)
2007
33
Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (17230453)
2007
34
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
35
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
36
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (17101893)
2006
37
REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. (16228998)
2006
38
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. (16217051)
2005
39
A case of marital discord and secondary depression with attempted suicide resulting from REM sleep behavior disorder in a 35-year-old woman. (15033135)
2004
40
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. (11902423)
2002
41
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
42
Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder. (12489892)
2002
43
Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. (12405541)
2002
44
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
45
Treatment of REM sleep behavior disorder with donepezil: a report of three cases. (10994012)
2000
46
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. (10646174)
1999
47
REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. (9710004)
1998
48
REM sleep behavior disorder. (8114229)
1994
49
Carbamazepine in REM sleep behavior disorder. (8456232)
1993
50
Polysomnographic features of REM sleep behavior disorder: development of a scoring method. (1620348)
1992

Variations for Rem Sleep Behavior Disorder

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Expression for genes affiliated with Rem Sleep Behavior Disorder

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Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

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Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SLC6A3, SNCA
29.3SLC6A3, SNCA
3
Show member pathways
Serotonin Transporter Activity38
9.3SLC6A3, ACHE
4
Show member pathways
Proteasome Degradation38
Immune response Antigen presentation by MHC class I60
8.5SLC6A3, RPS27A, SNCA

Compounds for genes affiliated with Rem Sleep Behavior Disorder

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Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1atropine45 30 1311.8SNCA, ACHE
21-benzyl-1,2,3,4-tetrahydroisoquinoline459.7SLC6A3, SNCA
3ephedrine45 30 1311.7SLC6A3, ACHE
4piperidine459.7SLC6A3, ACHE
51 methyl 4 phenylpyridinium459.7SLC6A3, SNCA
6apomorphine30 45 1311.7SLC6A3, SNCA
7amphetamine45 51 1311.7SNCA, SLC6A3
8carbachol45 30 1311.5ACHE, SNCA
9thioflavine s459.5RPS27A, SNCA
10cocaine45 1310.5SLC6A3, SNCA
11formate459.5RPS27A, SNCA
12guanidine hydrochloride459.4SNCA, RPS27A
134-hydroxynonenal45 2610.4SNCA, RPS27A
14silver459.4SNCA, RPS27A
15geldanamycin45 51 61 1312.4SNCA, RPS27A
16lactacystin459.4RPS27A, SNCA
17sodium dodecylsulfate459.4RPS27A, SNCA
18selegiline45 1310.2SLC6A3, SNCA, ACHE
19biotin45 26 1311.2RPS27A, SLC6A3
20nicotine45 30 51 1312.2ACHE, SLC6A3
21mg 13245 6110.2RPS27A, SNCA
22choline45 26 1311.2SLC6A3, SNCA, ACHE
23carbon459.0SLC6A3, RPS27A
24gaba459.0SLC6A3, RPS27A
25rotenone458.9SNCA, RPS27A, SLC6A3
26methamphetamine45 51 1310.9SLC6A3, RPS27A, SNCA
276-hydroxydopamine458.9SNCA, RPS27A, SLC6A3
28mptp458.9SLC6A3, RPS27A, SNCA
29levodopa45 139.9SNCA, RPS27A, SLC6A3
30valine458.9SNCA, RPS27A, SLC6A3
31nmda45 309.9ACHE, RPS27A, SLC6A3
32h2o2458.8SNCA, RPS27A, SLC6A3
33tacrolimus45 51 1310.8RPS27A, SNCA
34arginine458.8SLC6A3, RPS27A, SNCA
35alanine458.8SLC6A3, RPS27A, SNCA
36cysteine458.7SLC6A3, RPS27A, SNCA
37acetylcholine45 51 30 26 1312.4SLC6A3, RPS27A, SNCA, ACHE
38dopamine45 30 26 1311.4ACHE, SNCA, RPS27A, SLC6A3
39glutamate458.4ACHE, SNCA, RPS27A, SLC6A3
40serine458.3ACHE, SNCA, RPS27A, SLC6A3

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

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Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.5SLC6A3, SNCA, ACHE
2plasma membraneGO:00058868.0SLC6A3, RPS27A, SNCA, ACHE

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1phospholipid metabolic processGO:00066449.4SNCA, ACHE
2dopamine biosynthetic processGO:00424169.4SLC6A3, SNCA
3receptor internalizationGO:00316239.3ACHE, SNCA
4neurotransmitter biosynthetic processGO:00421369.3SLC6A3, ACHE
5agingGO:00075689.0SLC6A3, SNCA

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:00474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

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Sources for Rem Sleep Behavior Disorder

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet