MCID: RMS001
MIFTS: 35

Rem Sleep Behavior Disorder malady

Summaries for Rem Sleep Behavior Disorder

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Disease Ontology:9 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards based summary: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to dementia and pure autonomic failure. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds atropine and 1-benzyl-1,2,3,4-tetrahydroisoquinoline have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Aliases & Classifications for Rem Sleep Behavior Disorder

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH
See all sources

Rem Sleep Behavior Disorder, Aliases & Descriptions:

Name: Rem Sleep Behavior Disorder 9 43 60
 
Rapid Eye Movement Sleep Behavior Disorder 9


External Ids:

Disease Ontology9 DOID:9091
ICD9CM27 327.42
SNOMED-CT55 415238003
MeSH33 D020187

Related Diseases for Rem Sleep Behavior Disorder

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Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1dementia30.8SNCA, ACHE, SLC6A3, RPS27A
2pure autonomic failure30.7ACHE, SNCA
3tauopathy30.7SNCA, RPS27A
4machado-joseph disease30.6SLC6A3, SNCA, RPS27A
5multiple system atrophy30.5RPS27A, SLC6A3, SNCA
6alzheimer disease29.8SLC6A3, RPS27A, SNCA, ACHE
7narcolepsy10.8
8sleep apnea10.7
9synucleinopathy10.7
10obstructive sleep apnea10.7
11bruxism10.6
12limbic encephalitis10.6
13sleep disorder10.6
14rheumatoid arthritis10.5
15arthritis10.5
16corticobasal degeneration10.5
17hypersomnia10.4
18myoclonus10.4
19supranuclear palsy, progressive10.3SLC6A3
20obsessive-compulsive disorder10.3
21alexithymia10.3
22cerebritis10.3
23restless legs syndrome10.3
24encephalitis10.3
25impulse control disorder10.3
26leukodystrophy10.3
27pancreatitis10.3
28neurologic diseases10.3
29chiari malformation10.3
30ataxia10.3
31autonomic dysfunction10.3
32neuronal intranuclear inclusion disease10.3RPS27A
33essential tremor10.1SNCA, SLC6A3
34dementia, lewy body10.1SLC6A3, SNCA
35neurilemmoma10.1ACHE, SNCA
36cerebrovascular disease10.1SLC6A3, ACHE
37psychotic disorder10.1SLC6A3, ACHE
38down syndrome10.0SNCA, ACHE
39neuroaxonal dystrophy10.0RPS27A, SNCA
40alcohol dependence10.0SNCA, SLC6A3
41creutzfeldt-jakob disease10.0SNCA, RPS27A
42spinocerebellar ataxia10.0RPS27A, SNCA
43motor neuron disease10.0RPS27A, SNCA
44alcohol abuse10.0RPS27A, SLC6A3
45pheochromocytoma10.0SLC6A3, SNCA
46epilepsy syndrome10.0ACHE, SLC6A3
47myositis10.0SNCA, RPS27A
48amyloidosis9.9SNCA, RPS27A
49brain cancer9.9ACHE, SNCA
50schizophrenia9.8SLC6A3, SNCA, ACHE

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Symptoms for Rem Sleep Behavior Disorder

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Drugs & Therapeutics for Rem Sleep Behavior Disorder

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Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

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Anatomical Context for Rem Sleep Behavior Disorder

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MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

31
Eye, Brain, Testes, Heart, Pons

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

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MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

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Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 307)
idTitleAuthorsYear
1
Parkinson disease with REM sleep behavior disorder: features, I+-synuclein, and inflammation. (25663225)
2015
2
Validation study of REM sleep behavior disorder questionnaire-Hong Kong (RBDQ-HK) in east China. (24938584)
2014
3
Brainstem infarcts predict REM sleep behavior disorder in acute ischemic stroke. (24758223)
2014
4
From bench to bed: putative animal models of REM sleep behavior disorder (RBD). (23338670)
2013
5
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. (22989561)
2013
6
Characteristics of REM sleep behavior disorder in childhood. (22505856)
2012
7
I+-Synuclein and anti-I+-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls. (23284971)
2012
8
Environmental risk factors for REM sleep behavior disorder: a multicenter case-control study. (22744670)
2012
9
Challenging the myth of REM sleep behavior disorder: no evidence of heightened aggressiveness in dreams. (22503942)
2012
10
A motor signature of REM sleep behavior disorder. (22173891)
2012
11
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it? (22136900)
2011
12
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
13
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
14
Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder. (21538520)
2011
15
Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. (22205591)
2011
16
Does idiopathic REM sleep behavior disorder (iRBD) really exist? What are the potential markers of neurodegeneration in iRBD? (22136899)
2011
17
Automatic REM sleep detection associated with idiopathic rem sleep Behavior Disorder. (22255722)
2011
18
REM sleep behavior disorder in psychiatric populations. (20797385)
2010
19
REM sleep behavior disorder is not linked to postural instability and gait dysfunction in Parkinson. (20629146)
2010
20
The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. (19968708)
2010
21
REM sleep behavior disorder in 703 sleep-disorder patients: the importance of eliciting a comprehensive sleep history. (20022299)
2010
22
Cardiac 123I-MIBG uptake is reduced more markedly in patients with REM sleep behavior disorder than in those with early stage Parkinson's disease. (20097595)
2010
23
Video-clinical corners. Snoring, penile erection and loss of reflexive consciousness during REM sleep behavior disorder. (20817552)
2010
24
Three-year follow-up on the accumulation of cardiac (123)I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (19307152)
2009
25
The relation between abnormal behaviors and REM sleep microstructure in patients with REM sleep behavior disorder. (18359665)
2009
26
Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. (19204265)
2009
27
A brainstem inflammatory lesion causing REM sleep behavior disorder and sleepwalking (parasomnia overlap disorder). (19345142)
2009
28
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
29
Video analysis of motor events in REM sleep behavior disorder. (17516467)
2007
30
REM sleep behavior disorder and narcoleptic features in anti-Ma2-associated encephalitis. (17580598)
2007
31
Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. (17702272)
2007
32
Relationship between visual hallucinations and REM sleep behavior disorder in patients with Parkinson's disease. (17913346)
2007
33
Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (17230453)
2007
34
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
35
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
36
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (17101893)
2006
37
REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson's disease. (16228998)
2006
38
Aggressive dream content without daytime aggressiveness in REM sleep behavior disorder. (16217051)
2005
39
A case of marital discord and secondary depression with attempted suicide resulting from REM sleep behavior disorder in a 35-year-old woman. (15033135)
2004
40
REM sleep behavior disorder: clinical, developmental, and neuroscience perspectives 16 years after its formal identification in SLEEP. (11902423)
2002
41
Article reviewed: REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (14592242)
2002
42
Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder. (12489892)
2002
43
Dementia with Lewy bodies may present as dementia and REM sleep behavior disorder without parkinsonism or hallucinations. (12405541)
2002
44
REM sleep behavior disorder in sleep-disordered patients with versus without Parkinson's disease: is there a need for polysomnography? (11412865)
2001
45
Treatment of REM sleep behavior disorder with donepezil: a report of three cases. (10994012)
2000
46
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. (10646174)
1999
47
REM sleep behavior disorder and degenerative dementia: an association likely reflecting Lewy body disease. (9710004)
1998
48
REM sleep behavior disorder. (8114229)
1994
49
Carbamazepine in REM sleep behavior disorder. (8456232)
1993
50
Polysomnographic features of REM sleep behavior disorder: development of a scoring method. (1620348)
1992

Variations for Rem Sleep Behavior Disorder

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Expression for genes affiliated with Rem Sleep Behavior Disorder

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Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

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Pathways related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SLC6A3, SNCA
29.3SLC6A3, SNCA
3
Show member pathways
Serotonin Transporter Activity36
9.3SLC6A3, ACHE
4
Show member pathways
Proteasome Degradation36
Immune response Antigen presentation by MHC class I58
8.5SLC6A3, RPS27A, SNCA

Compounds for genes affiliated with Rem Sleep Behavior Disorder

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Compounds related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

(show all 40)
idCompoundScoreTop Affiliating Genes
1atropine43 28 1211.8SNCA, ACHE
21-benzyl-1,2,3,4-tetrahydroisoquinoline439.7SLC6A3, SNCA
3ephedrine43 28 1211.7SLC6A3, ACHE
4piperidine439.7SLC6A3, ACHE
51 methyl 4 phenylpyridinium439.7SLC6A3, SNCA
6apomorphine28 43 1211.7SLC6A3, SNCA
7amphetamine43 49 1211.7SNCA, SLC6A3
8carbachol43 28 1211.5ACHE, SNCA
9thioflavine s439.5RPS27A, SNCA
10cocaine43 1210.5SLC6A3, SNCA
11formate439.5RPS27A, SNCA
12guanidine hydrochloride439.4SNCA, RPS27A
134-hydroxynonenal43 2410.4SNCA, RPS27A
14silver439.4SNCA, RPS27A
15geldanamycin43 49 59 1212.4SNCA, RPS27A
16lactacystin439.4RPS27A, SNCA
17sodium dodecylsulfate439.4RPS27A, SNCA
18selegiline43 1210.2SLC6A3, SNCA, ACHE
19biotin43 24 1211.2RPS27A, SLC6A3
20nicotine43 28 49 1212.2ACHE, SLC6A3
21mg 13243 5910.2RPS27A, SNCA
22choline43 24 1211.2SLC6A3, SNCA, ACHE
23carbon439.0SLC6A3, RPS27A
24gaba439.0SLC6A3, RPS27A
25rotenone438.9SNCA, RPS27A, SLC6A3
26methamphetamine43 49 1210.9SLC6A3, RPS27A, SNCA
276-hydroxydopamine438.9SNCA, RPS27A, SLC6A3
28mptp438.9SLC6A3, RPS27A, SNCA
29levodopa43 129.9SNCA, RPS27A, SLC6A3
30valine438.9SNCA, RPS27A, SLC6A3
31nmda43 289.9ACHE, RPS27A, SLC6A3
32h2o2438.8SNCA, RPS27A, SLC6A3
33tacrolimus43 49 1210.8RPS27A, SNCA
34arginine438.8SLC6A3, RPS27A, SNCA
35alanine438.8SLC6A3, RPS27A, SNCA
36cysteine438.7SLC6A3, RPS27A, SNCA
37acetylcholine43 49 28 24 1212.4SLC6A3, RPS27A, SNCA, ACHE
38dopamine43 28 24 1211.4ACHE, SNCA, RPS27A, SLC6A3
39glutamate438.4ACHE, SNCA, RPS27A, SLC6A3
40serine438.3ACHE, SNCA, RPS27A, SLC6A3

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

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Cellular components related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axonGO:00304248.5SLC6A3, SNCA, ACHE
2plasma membraneGO:00058868.0SLC6A3, RPS27A, SNCA, ACHE

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1phospholipid metabolic processGO:00066449.4ACHE, SNCA
2dopamine biosynthetic processGO:00424169.4SNCA, SLC6A3
3receptor internalizationGO:00316239.3ACHE, SNCA
4neurotransmitter biosynthetic processGO:00421369.3ACHE, SLC6A3
5agingGO:00075689.0SNCA, SLC6A3

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:00474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

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Sources for Rem Sleep Behavior Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet