MCID: RMS001
MIFTS: 28

Rem Sleep Behavior Disorder malady

Summaries for Rem Sleep Behavior Disorder

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to parkinson's disease and alzheimer's disease. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Related mouse phenotype taste/olfaction.

Wikipedia:64 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Aliases & Classifications for Rem Sleep Behavior Disorder

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM
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Aliases & Descriptions:

rem sleep behavior disorder 8 45 61
rapid eye movement sleep behavior disorder 8


External Ids:

Disease Ontology8 DOID:9091
MeSH35 D020187
SNOMED-CT57 415238003
ICD9CM27 327.42

Related Diseases for Rem Sleep Behavior Disorder

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.7RPS27A, SNCA, SLC6A3
2alzheimer's disease30.8RPS27A, SNCA, SLC6A3, ACHE
3progressive supranuclear palsy30.8SLC6A3
4lewy body dementia30.6SNCA, SLC6A3
5spinocerebellar ataxia type 330.6RPS27A, SNCA, SLC6A3
6tauopathy30.4SNCA, RPS27A
7pure autonomic failure30.4ACHE, SNCA
8frontotemporal dementia30.4ACHE, SNCA, RPS27A
9memory impairment30.4ACHE, SLC6A3, SNCA
10sleep disorder11.5
11narcolepsy10.8
12sleep apnea10.6
13bruxism10.6
14limbic encephalitis10.6
15brain disease10.5
16machado-joseph disease10.5
17corticobasal degeneration10.5
18parkinson disease 110.5
19parkinson disease 1210.5
20hypersomnia10.4
21myoclonus10.4
22restless legs syndrome10.3
23obsessive-compulsive disorder10.3
24alexithymia10.3
25n syndrome10.3
26arthritis10.3
27speech disorder10.3
28chiari malformations10.3
29leukodystrophy, adult-onset, autosomal dominant10.3
30autonomic dysfunction10.3
31neuronal intranuclear inclusion disease10.0RPS27A
32cocaine abuse10.0SLC6A3
33cocaine dependence10.0SLC6A3
34drug dependence10.0SLC6A3
35neuroaxonal dystrophy10.0SNCA, RPS27A
36creutzfeldt-jakob syndrome10.0RPS27A, SNCA
37spinocerebellar ataxia10.0RPS27A, SNCA
38ischemia10.0SLC6A3, SNCA
39essential tremor10.0SLC6A3, SNCA
40amyloid tumor10.0ACHE, RPS27A
41neurilemmoma10.0SNCA, ACHE
42alcohol abuse10.0RPS27A, SLC6A3
43down syndrome10.0SNCA, ACHE
44psychotic disorder10.0SLC6A3, ACHE
45striatonigral degeneration10.0RPS27A, SNCA, SLC6A3
46movement disease10.0RPS27A, SNCA, SLC6A3
47amyotrophic lateral sclerosis10.0SLC6A3, SNCA, RPS27A
48multiple system atrophy10.0RPS27A, SNCA, SLC6A3
49motor neuron disease10.0RPS27A, SNCA
50cerebrovascular disease10.0ACHE, SLC6A3

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Clinical Features for Rem Sleep Behavior Disorder

Drugs & Therapeutics for Rem Sleep Behavior Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Rem Sleep Behavior Disorder

Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Search CenterWatch for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

Anatomical Context for Rem Sleep Behavior Disorder

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

Sources:
51PubMed
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Articles related to Rem Sleep Behavior Disorder:

idTitleAuthorsYear
1
Remitting REM sleep behavior disorder as the initial sign of multiple sclerosis. (14592179)
2002

Genetic Variations for Rem Sleep Behavior Disorder

Expression for genes affiliated with Rem Sleep Behavior Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN
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Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SNCA, SLC6A3
29.3SLC6A3, SNCA
39.0SLC6A3, ACHE
4
Hide members
9.0ACHE, SLC6A3
5
Hide members
8.8SLC6A3, SNCA, RPS27A

Compounds for genes affiliated with Rem Sleep Behavior Disorder

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
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Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thioflavine s459.8RPS27A, SNCA
2formate459.8SNCA, RPS27A
31-benzyl-1,2,3,4-tetrahydroisoquinoline459.7SNCA, SLC6A3
4guanidine hydrochloride459.7SNCA, RPS27A
5silver459.7RPS27A, SNCA
64-hydroxynonenal45 2410.7RPS27A, SNCA
71 methyl 4 phenylpyridinium459.7SLC6A3, SNCA
8apomorphine45 29 1111.7SNCA, SLC6A3
9geldanamycin45 50 60 1112.7SNCA, RPS27A
10amphetamine45 1110.6SLC6A3, SNCA
11lactacystin459.6SNCA, RPS27A
12sodium dodecylsulfate459.6SNCA, RPS27A
13biotin45 11 2411.4RPS27A, SLC6A3
14atropine45 29 1111.4ACHE, SNCA
15ephedrine29 45 1111.4ACHE, SLC6A3
16cocaine45 1110.4SLC6A3, SNCA
17piperidine459.4ACHE, SLC6A3
18mg 13245 6010.3RPS27A, SNCA
19carbon459.3SLC6A3, RPS27A
20rotenone459.2SLC6A3, SNCA, RPS27A
21methamphetamine45 50 1111.2RPS27A, SNCA, SLC6A3
226-hydroxydopamine459.2SLC6A3, SNCA, RPS27A
23mptp459.2SLC6A3, SNCA, RPS27A
24levodopa45 1110.2SLC6A3, SNCA, RPS27A
25valine459.2RPS27A, SNCA, SLC6A3
26carbachol45 29 1111.1ACHE, SNCA
27h2o2459.1RPS27A, SNCA, SLC6A3
28arginine459.0RPS27A, SNCA, SLC6A3
29alanine459.0RPS27A, SNCA, SLC6A3
30selegiline45 119.9ACHE, SLC6A3, SNCA
31choline45 11 2410.9ACHE, SLC6A3, SNCA
32nmda45 299.9RPS27A, SLC6A3, ACHE
33cysteine458.5SLC6A3, SNCA, RPS27A
34acetylcholine45 50 29 11 2412.4RPS27A, SNCA, SLC6A3, ACHE
35dopamine45 29 11 2411.4RPS27A, SNCA, SLC6A3, ACHE
36glutamate458.4RPS27A, SNCA, SLC6A3, ACHE
37serine458.3ACHE, SLC6A3, SNCA, RPS27A

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

Sources:
16Gene Ontology
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Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.5ACHE, SLC6A3, SNCA

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine biosynthetic processGO:0424169.4SLC6A3, SNCA
2phospholipid metabolic processGO:0066449.1ACHE, SNCA
3agingGO:0075689.0SLC6A3, SNCA
4receptor internalizationGO:0316239.0SNCA, ACHE
5neurotransmitter biosynthetic processGO:0421369.0ACHE, SLC6A3

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

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  • Antibodies

Sources for Rem Sleep Behavior Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet