MCID: RMS001
MIFTS: 40

Rem Sleep Behavior Disorder malady

Summaries for Rem Sleep Behavior Disorder

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to parkinson's disease and dementia. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Wikipedia:63 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Aliases & Classifications for Rem Sleep Behavior Disorder

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
See all sources

Aliases & Descriptions:

rem sleep behavior disorder 8 44 60
rapid eye movement sleep behavior disorder 8


External Ids:

Disease Ontology8 DOID:9091
MeSH34 D020187
SNOMED-CT56 415238003
ICD9CM27 327.42

Related Diseases for Rem Sleep Behavior Disorder

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.6RPS27A, SNCA, SLC6A3
2dementia31.3ACHE, SLC6A3, SNCA, RPS27A
3lewy body dementia31.0SNCA, SLC6A3
4progressive supranuclear palsy30.7SLC6A3
5alzheimer's disease30.7RPS27A, SNCA, SLC6A3, ACHE
6tauopathy30.6SNCA, RPS27A
7movement disease30.6RPS27A, SNCA, SLC6A3
8spinocerebellar ataxia type 330.6RPS27A, SNCA, SLC6A3
9multiple system atrophy30.6RPS27A, SNCA, SLC6A3
10frontotemporal dementia30.4ACHE, SNCA, RPS27A
11sleep disorder11.5
12narcolepsy10.8
13bruxism10.5
14multiple sclerosis10.5
15machado-joseph disease10.4
16eye disease10.4
17cerebritis10.3
18restless legs syndrome10.3
19obsessive-compulsive disorder10.3
20alexithymia10.3
21arthritis10.3
22brain disease10.3
23encephalitis10.3
24leukodystrophy10.3
25pancreatitis10.3
26rheumatoid arthritis10.3
27speech disorder10.3
28neurologic diseases10.3
29neuronal intranuclear inclusion disease10.0RPS27A
30cocaine abuse10.0SLC6A3
31cocaine dependence10.0SLC6A3
32drug dependence10.0SLC6A3
33neuroaxonal dystrophy10.0SNCA, RPS27A
34creutzfeldt-jakob syndrome10.0RPS27A, SNCA
35spinocerebellar ataxia10.0RPS27A, SNCA
36ischemia10.0SLC6A3, SNCA
37essential tremor10.0SLC6A3, SNCA
38pure autonomic failure10.0ACHE, SNCA
39amyloid tumor10.0ACHE, RPS27A
40neurilemmoma10.0SNCA, ACHE
41alcohol abuse10.0RPS27A, SLC6A3
42down syndrome10.0SNCA, ACHE
43psychotic disorder10.0SLC6A3, ACHE
44striatonigral degeneration10.0RPS27A, SNCA, SLC6A3
45amyotrophic lateral sclerosis10.0SLC6A3, SNCA, RPS27A
46motor neuron disease10.0RPS27A, SNCA
47cerebrovascular disease10.0ACHE, SLC6A3
48myopathy10.0RPS27A, ACHE
49vascular dementia10.0ACHE, SNCA, RPS27A
50pick's disease10.0RPS27A, SNCA, ACHE

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Clinical Features for Rem Sleep Behavior Disorder

About this section

Drugs & Therapeutics for Rem Sleep Behavior Disorder

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rem Sleep Behavior Disorder

Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Search CenterWatch for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

About this section

Anatomical Context for Rem Sleep Behavior Disorder

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

32
Eye, Brain, Testes, Heart

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

About this section
Sources:
50PubMed
See all sources

Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 275)
idTitleAuthorsYear
1
Prodromal Parkinson's disease--using REM sleep behavior disorder as a window. (24262156)
2014
2
REM sleep behavior disorder in Parkinson's disease: a questionnaire-based survey. (23319905)
2013
3
REM sleep behavior disorder: from epidemiology to heterogeneity. (23904667)
2013
4
MRI and pathology of REM sleep behavior disorder in dementia with Lewy bodies. (24107861)
2013
5
Cyclic alternating pattern analysis in REM sleep behavior disorder. (22367462)
2013
6
REM sleep behavior disorder in Parkinson's disease--is there a gender difference? (22726815)
2013
7
Ethical considerations in REM sleep behavior disorder. (23385702)
2013
8
A motor signature of REM sleep behavior disorder. (22173891)
2012
9
A preliminary quantitative analysis of REM sleep chin EMG in Parkinson's disease with or without REM sleep behavior disorder. (22440085)
2012
10
Hiding in plain sight: risk factors for REM sleep behavior disorder. (22744669)
2012
11
REM sleep behavior disorder: from dreams to neurodegeneration. (22019718)
2012
12
Secondary ''incidental'' REM sleep behavior disorder: do we ever think of it? (22136900)
2011
13
Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder. (21714973)
2011
14
Changing demographics in REM sleep behavior disorder: possible effect of autoimmunity and antidepressants. (21317035)
2011
15
Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy. (22205591)
2011
16
The strong presence of REM sleep behavior disorder in PD: clinical and research implications. (21832232)
2011
17
Longitudinal study of cognitive function in idiopathic REM sleep behavior disorder. (21532955)
2011
18
Best practice guide for the treatment of REM sleep behavior disorder (RBD). (20191945)
2010
19
REM sleep behavior disorder: Updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. (20146689)
2010
20
Olfactory dysfunction in Japanese patients with idiopathic REM sleep behavior disorder: comparison of data using the university of Pennsylvania smell identification test and odor stick identification test for Japanese. (20568095)
2010
21
Relationship between (123)I-MIBG scintigrams and REM sleep behavior disorder in Parkinson's disease. (20846893)
2010
22
Severity of REM atonia loss in idiopathic REM sleep behavior disorder predicts Parkinson disease. (20083800)
2010
23
Diffuse occipital hypometabolism on [18 F]-FDG PET scans in patients with idiopathic REM sleep behavior disorder: prodromal dementia with Lewy bodies? (20860570)
2010
24
Idiopathic REM sleep behavior disorder in the transition to degenerative disease. (19768814)
2009
25
The clinical and pathophysiological relevance of REM sleep behavior disorder in neurodegenerative diseases. (19362028)
2009
26
A lesson from anatomy: focal brain lesions causing REM sleep behavior disorder. (18606568)
2009
27
Excessive muscle activity increases over time in idiopathic REM sleep behavior disorder. (19750919)
2009
28
Sleep apnea and REM sleep behavior disorder in patients with Chiari malformations. (18641869)
2008
29
Quantification of electromyographic activity during REM sleep in multiple muscles in REM sleep behavior disorder. (18517042)
2008
30
Quantification of tonic and phasic muscle activity in REM sleep behavior disorder. (18303560)
2008
31
123I-MIBG cardiac scintigraphy provides clues to the underlying neurodegenerative disorder in idiopathic REM sleep behavior disorder. (18517041)
2008
32
Visual hallucinations and symptoms of REM sleep behavior disorder in Parkinsonian tauopathies. (18023069)
2008
33
Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder. (17702272)
2007
34
Decreased myocardial (123)I-MIBG uptake and impaired facial expression recognition in a patient with REM sleep behavior disorder. (17357134)
2007
35
Rhythmic movements in idiopathic REM sleep behavior disorder. (17580329)
2007
36
Pathophysiologic mechanisms in REM sleep behavior disorder. (17355839)
2007
37
A unique episode of REM sleep behavior disorder triggered during surgery for Parkinson's disease. (17196620)
2007
38
REM sleep behavior disorder and epileptic phenomena: clinical aspects of the comorbidity. (17239112)
2006
39
REM sleep behavior disorder--psychiatric presentations: a case series from the United Kingdom. (17561615)
2005
40
Clinical and research implications of a validated polysomnographic scoring method for REM sleep behavior disorder. (16218073)
2005
41
Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): does the idiopathic form of RBD really exist? (14718695)
2004
42
Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. (14872020)
2004
43
The effects of pramipexole in REM sleep behavior disorder. (14638967)
2003
44
Brainstem proton magnetic resonance spectroscopy in idopathic REM sleep behavior disorder. (12489892)
2002
45
The importance of sleep medicine consultation for diagnosis of REM sleep behavior disorder in most patients with Parkinson's disease. (14592156)
2002
46
REM sleep behavior disorder. (10996567)
2000
47
Subclinical REM sleep behavior disorder in a patient with corticobasal degeneration. (9415950)
1997
48
Cardiac autonomic activity during wakefulness and sleep in REM sleep behavior disorder. (8843526)
1996
49
A first case of progressive supranuclear palsy and pre-clinical REM sleep behavior disorder presenting as inhibition of speech during wakefulness and somniloquy with phasic muscle twitching during REM sleep. (8950864)
1996
50
Carbamazepine in REM sleep behavior disorder. (8456232)
1993

Genetic Variations for Rem Sleep Behavior Disorder

About this section

Expression for genes affiliated with Rem Sleep Behavior Disorder

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 51QIAGEN
See all sources

Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SNCA, SLC6A3
29.3SLC6A3, SNCA
39.0SLC6A3, ACHE
4
Hide members
9.0ACHE, SLC6A3
5
Hide members
8.8SLC6A3, SNCA, RPS27A

Compounds for genes affiliated with Rem Sleep Behavior Disorder

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.8RPS27A, SNCA
2formate449.8SNCA, RPS27A
31-benzyl-1,2,3,4-tetrahydroisoquinoline449.7SNCA, SLC6A3
4guanidine hydrochloride449.7SNCA, RPS27A
5silver449.7RPS27A, SNCA
64-hydroxynonenal44 2410.7RPS27A, SNCA
71 methyl 4 phenylpyridinium449.7SLC6A3, SNCA
8apomorphine44 28 1111.7SNCA, SLC6A3
9geldanamycin44 49 59 1112.7SNCA, RPS27A
10amphetamine44 1110.6SLC6A3, SNCA
11lactacystin449.6SNCA, RPS27A
12sodium dodecylsulfate449.6SNCA, RPS27A
13biotin44 11 2411.4RPS27A, SLC6A3
14atropine44 28 1111.4ACHE, SNCA
15ephedrine28 44 1111.4ACHE, SLC6A3
16cocaine44 1110.4SLC6A3, SNCA
17piperidine449.4ACHE, SLC6A3
18mg 13244 5910.3RPS27A, SNCA
19carbon449.3SLC6A3, RPS27A
20rotenone449.2SLC6A3, SNCA, RPS27A
21methamphetamine44 49 1111.2RPS27A, SNCA, SLC6A3
226-hydroxydopamine449.2SLC6A3, SNCA, RPS27A
23mptp449.2SLC6A3, SNCA, RPS27A
24levodopa44 1110.2SLC6A3, SNCA, RPS27A
25valine449.2RPS27A, SNCA, SLC6A3
26carbachol44 28 1111.1ACHE, SNCA
27h2o2449.1RPS27A, SNCA, SLC6A3
28arginine449.0RPS27A, SNCA, SLC6A3
29alanine449.0RPS27A, SNCA, SLC6A3
30selegiline44 119.9ACHE, SLC6A3, SNCA
31choline44 11 2410.9ACHE, SLC6A3, SNCA
32nmda44 289.9RPS27A, SLC6A3, ACHE
33cysteine448.5SLC6A3, SNCA, RPS27A
34acetylcholine44 49 28 11 2412.4RPS27A, SNCA, SLC6A3, ACHE
35dopamine44 28 11 2411.4RPS27A, SNCA, SLC6A3, ACHE
36glutamate448.4RPS27A, SNCA, SLC6A3, ACHE
37serine448.3ACHE, SLC6A3, SNCA, RPS27A

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.5ACHE, SLC6A3, SNCA

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine biosynthetic processGO:0424169.4SLC6A3, SNCA
2phospholipid metabolic processGO:0066449.1ACHE, SNCA
3agingGO:0075689.0SLC6A3, SNCA
4receptor internalizationGO:0316239.0SNCA, ACHE
5neurotransmitter biosynthetic processGO:0421369.0ACHE, SLC6A3

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rem Sleep Behavior Disorder

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet