MCID: RMS001
MIFTS: 40

Rem Sleep Behavior Disorder malady

Summaries for Rem Sleep Behavior Disorder

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement.

MalaCards: Rem Sleep Behavior Disorder, also known as rapid eye movement sleep behavior disorder, is related to parkinson's disease and dementia. An important gene associated with Rem Sleep Behavior Disorder is SNCA (synuclein, alpha (non A4 component of amyloid precursor)), and among its related pathways are Alpha-synuclein signaling and Parkinsons Disease Pathway. The compounds thioflavine s and formate have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and testes, and related mouse phenotype taste/olfaction.

Wikipedia:63 Rapid eye movement sleep behavior disorder (RBD) is a sleep disorder (more specifically a parasomnia)... more...

Aliases & Classifications for Rem Sleep Behavior Disorder

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM
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Aliases & Descriptions:

rem sleep behavior disorder 8 44 60
rapid eye movement sleep behavior disorder 8


External Ids:

Disease Ontology8 DOID:9091
MeSH34 D020187
SNOMED-CT56 415238003
ICD9CM27 327.42

Related Diseases for Rem Sleep Behavior Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rem Sleep Behavior Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.6RPS27A, SNCA, SLC6A3
2dementia31.3ACHE, SLC6A3, SNCA, RPS27A
3lewy body dementia31.0SNCA, SLC6A3
4progressive supranuclear palsy30.7SLC6A3
5alzheimer's disease30.7RPS27A, SNCA, SLC6A3, ACHE
6tauopathy30.6SNCA, RPS27A
7movement disease30.6RPS27A, SNCA, SLC6A3
8spinocerebellar ataxia type 330.6RPS27A, SNCA, SLC6A3
9multiple system atrophy30.6RPS27A, SNCA, SLC6A3
10frontotemporal dementia30.4ACHE, SNCA, RPS27A
11sleep disorder11.5
12narcolepsy10.8
13bruxism10.5
14multiple sclerosis10.5
15machado-joseph disease10.4
16eye disease10.4
17cerebritis10.3
18restless legs syndrome10.3
19obsessive-compulsive disorder10.3
20alexithymia10.3
21arthritis10.3
22brain disease10.3
23encephalitis10.3
24leukodystrophy10.3
25pancreatitis10.3
26rheumatoid arthritis10.3
27speech disorder10.3
28neurologic diseases10.3
29neuronal intranuclear inclusion disease10.0RPS27A
30cocaine abuse10.0SLC6A3
31cocaine dependence10.0SLC6A3
32drug dependence10.0SLC6A3
33neuroaxonal dystrophy10.0SNCA, RPS27A
34creutzfeldt-jakob syndrome10.0RPS27A, SNCA
35spinocerebellar ataxia10.0RPS27A, SNCA
36ischemia10.0SLC6A3, SNCA
37essential tremor10.0SLC6A3, SNCA
38pure autonomic failure10.0ACHE, SNCA
39amyloid tumor10.0ACHE, RPS27A
40neurilemmoma10.0SNCA, ACHE
41alcohol abuse10.0RPS27A, SLC6A3
42down syndrome10.0SNCA, ACHE
43psychotic disorder10.0SLC6A3, ACHE
44striatonigral degeneration10.0RPS27A, SNCA, SLC6A3
45amyotrophic lateral sclerosis10.0SLC6A3, SNCA, RPS27A
46motor neuron disease10.0RPS27A, SNCA
47cerebrovascular disease10.0ACHE, SLC6A3
48myopathy10.0RPS27A, ACHE
49vascular dementia10.0ACHE, SNCA, RPS27A
50pick's disease10.0RPS27A, SNCA, ACHE

Graphical network of the top 20 diseases related to Rem Sleep Behavior Disorder:



Diseases related to rem sleep behavior disorder

Clinical Features for Rem Sleep Behavior Disorder

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Drugs & Therapeutics for Rem Sleep Behavior Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rem Sleep Behavior Disorder

Drug clinical trials:

Search ClinicalTrials for Rem Sleep Behavior Disorder

Search NIH Clinical Center for Rem Sleep Behavior Disorder

Search CenterWatch for Rem Sleep Behavior Disorder

Genetic Tests for Rem Sleep Behavior Disorder

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Anatomical Context for Rem Sleep Behavior Disorder

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32MalaCards
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MalaCards organs/tissues related to Rem Sleep Behavior Disorder:

32
Eye, Brain, Testes, Heart

Animal Models for Rem Sleep Behavior Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Rem Sleep Behavior Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053949.3SLC6A3, SNCA

Publications for Rem Sleep Behavior Disorder

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Sources:
50PubMed
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Articles related to Rem Sleep Behavior Disorder:

(show top 50)    (show all 275)
idTitleAuthorsYear
1
Factors associated with the effect of pramipexole on symptoms of idiopathic REM sleep behavior disorder. (22989561)
2013
2
Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorder. (23239509)
2013
3
Clinical significance of REM sleep behavior disorder in Parkinson's disease. (23218532)
2013
4
Comparison study of olfactory function and substantia nigra hyperechogenicity in idiopathic REM sleep behavior disorder, Parkinson's disease and normal control. (22843227)
2013
5
Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in a community-based sample. (23674939)
2013
6
Alexithymia associated with nightmare distress in idiopathic REM sleep behavior disorder. (24293771)
2013
7
Adult-onset autosomal dominant leukodystrophy presenting with REM sleep behavior disorder. (23243074)
2013
8
Normative EMG values during REM sleep for the diagnosis of REM sleep behavior disorder. (22654203)
2012
9
REM sleep behavior disorder and REM sleep without atonia as an early manifestation of degenerative neurological disease. (22328094)
2012
10
Validation of the Innsbruck REM sleep behavior disorder inventory. (23192924)
2012
11
Attenuated heart rate response in REM sleep behavior disorder and Parkinson's disease. (22555939)
2012
12
Amelioration of obstructive sleep apnea in REM sleep behavior disorder: implications for the neuromuscular control of OSA. (21731141)
2011
13
Clinical features associated with REM sleep behavior disorder symptoms in the early stages of Parkinson's disease. (20694845)
2011
14
REM sleep behavior disorder in psychiatric populations. (20797385)
2010
15
REM sleep behavior disorder. (20451035)
2010
16
Improved computation of the atonia index in normal controls and patients with REM sleep behavior disorder. (20817596)
2010
17
Idiopathic REM sleep behavior disorder and Parkinson's disease--two sides of one coin? (20550010)
2010
18
Rivastigmine-induced REM sleep behavior disorder (RBD) in a 88-year-old man with Alzheimer's disease. (20411699)
2010
19
Nonviolent elaborate behaviors may also occur in REM sleep behavior disorder. (19204265)
2009
20
Successful treatment of REM sleep behavior disorder with sodium oxybate. (19483483)
2009
21
The REM sleep behavior disorder screening questionnaire: validation study of a Japanese version. (19604719)
2009
22
The REM sleep behavior disorder odyssey. (19394252)
2009
23
Searching for a marker of REM sleep behavior disorder: submentalis muscle EMG amplitude analysis during sleep in patients with narcolepsy/cataplexy. (18853938)
2008
24
Cognition in REM sleep behavior disorder - A window into preclinical dementia? (17869575)
2008
25
Video analysis of motor events in REM sleep behavior disorder. (17516467)
2007
26
Testosterone not associated with violent dreams or REM sleep behavior disorder in men with Parkinson's. (17230453)
2007
27
EMG variance during polysomnography as an assessment for REM sleep behavior disorder. (18246986)
2007
28
Insights into REM sleep behavior disorder pathophysiology in brainstem-predominant Lewy body disease. (17157062)
2007
29
The REM sleep behavior disorder screening questionnaire--a new diagnostic instrument. (17894337)
2007
30
Absence of alterations in serum sex hormone levels in idiopathic REM sleep behavior disorder. (17580603)
2007
31
REM sleep behavior disorder initiated by acute brainstem multiple sclerosis. (16636256)
2006
32
Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. (17101893)
2006
33
Update on the pharmacology of REM sleep behavior disorder. (16966533)
2006
34
REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease. (17068986)
2006
35
Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder. (17190953)
2006
36
Brainstem 1H-MR spectroscopy in patients with Parkinson's disease with REM sleep behavior disorder and IPD patients without dream enactment behavior. (15936138)
2006
37
Severe obstructive sleep apnea/hypopnea mimicking REM sleep behavior disorder. (16171244)
2005
38
Idiopathic REM sleep behavior disorder: toward a better nosologic definition. (15753409)
2005
39
Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD. (16043794)
2005
40
Mirtazapine induces REM sleep behavior disorder (RBD) in parkinsonism. (12525729)
2003
41
Physiological and anatomical link between Parkinson-like disease and REM sleep behavior disorder. (12777684)
2003
42
REM sleep behavior disorder: a dopaminergic deficiency disorder? (14638948)
2003
43
REM sleep behavior disorder and vocal cord paralysis in Machado-Joseph disease. (14534924)
2003
44
Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy. (11481685)
2001
45
Presumed REM sleep behavior disorder arising from cataplexy and wakeful dreaming. (10767654)
2000
46
Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. (10646174)
1999
47
A controlled study of serum anti-locus ceruleus antibodies in REM sleep behavior disorder. (9381056)
1997
48
A parasomnia overlap disorder involving sleepwalking, sleep terrors, and REM sleep behavior disorder in 33 polysomnographically confirmed cases. (9456462)
1997
49
Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations. (9396020)
1997
50
Activation by selegiline (Eldepryle) of REM sleep behavior disorder in parkinsonism. (7747490)
1995

Genetic Variations for Rem Sleep Behavior Disorder

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Expression for genes affiliated with Rem Sleep Behavior Disorder

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rem Sleep Behavior Disorder

Search GEO for disease gene expression data for Rem Sleep Behavior Disorder.

Pathways for genes affiliated with Rem Sleep Behavior Disorder

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN
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Pathways related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3SNCA, SLC6A3
29.3SLC6A3, SNCA
39.0SLC6A3, ACHE
4
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9.0ACHE, SLC6A3
5
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8.8SLC6A3, SNCA, RPS27A

Compounds for genes affiliated with Rem Sleep Behavior Disorder

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

(show all 37)
idCompoundScoreTop Affiliating Genes
1thioflavine s449.8RPS27A, SNCA
2formate449.8SNCA, RPS27A
31-benzyl-1,2,3,4-tetrahydroisoquinoline449.7SNCA, SLC6A3
4guanidine hydrochloride449.7SNCA, RPS27A
5silver449.7RPS27A, SNCA
64-hydroxynonenal44 2410.7RPS27A, SNCA
71 methyl 4 phenylpyridinium449.7SLC6A3, SNCA
8apomorphine44 28 1111.7SNCA, SLC6A3
9geldanamycin44 49 59 1112.7SNCA, RPS27A
10amphetamine44 1110.6SLC6A3, SNCA
11lactacystin449.6SNCA, RPS27A
12sodium dodecylsulfate449.6SNCA, RPS27A
13biotin44 11 2411.4RPS27A, SLC6A3
14atropine44 28 1111.4ACHE, SNCA
15ephedrine28 44 1111.4ACHE, SLC6A3
16cocaine44 1110.4SLC6A3, SNCA
17piperidine449.4ACHE, SLC6A3
18mg 13244 5910.3RPS27A, SNCA
19carbon449.3SLC6A3, RPS27A
20rotenone449.2SLC6A3, SNCA, RPS27A
21methamphetamine44 49 1111.2RPS27A, SNCA, SLC6A3
226-hydroxydopamine449.2SLC6A3, SNCA, RPS27A
23mptp449.2SLC6A3, SNCA, RPS27A
24levodopa44 1110.2SLC6A3, SNCA, RPS27A
25valine449.2RPS27A, SNCA, SLC6A3
26carbachol44 28 1111.1ACHE, SNCA
27h2o2449.1RPS27A, SNCA, SLC6A3
28arginine449.0RPS27A, SNCA, SLC6A3
29alanine449.0RPS27A, SNCA, SLC6A3
30selegiline44 119.9ACHE, SLC6A3, SNCA
31choline44 11 2410.9ACHE, SLC6A3, SNCA
32nmda44 289.9RPS27A, SLC6A3, ACHE
33cysteine448.5SLC6A3, SNCA, RPS27A
34acetylcholine44 49 28 11 2412.4RPS27A, SNCA, SLC6A3, ACHE
35dopamine44 28 11 2411.4RPS27A, SNCA, SLC6A3, ACHE
36glutamate448.4RPS27A, SNCA, SLC6A3, ACHE
37serine448.3ACHE, SLC6A3, SNCA, RPS27A

GO Terms for genes affiliated with Rem Sleep Behavior Disorder

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16Gene Ontology
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Cellular components related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:0304248.5ACHE, SLC6A3, SNCA

Biological processes related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine biosynthetic processGO:0424169.4SLC6A3, SNCA
2phospholipid metabolic processGO:0066449.1ACHE, SNCA
3agingGO:0075689.0SLC6A3, SNCA
4receptor internalizationGO:0316239.0SNCA, ACHE
5neurotransmitter biosynthetic processGO:0421369.0ACHE, SLC6A3

Molecular functions related to Rem Sleep Behavior Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.3SLC6A3, SNCA

Products for genes affiliated with Rem Sleep Behavior Disorder

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Sources for Rem Sleep Behavior Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet