MCID: RNL097
MIFTS: 41

Renal Artery Disease malady

Nephrological diseases, Cardiovascular diseases categories

Aliases & Classifications for Renal Artery Disease

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Aliases & Descriptions for Renal Artery Disease:

Name: Renal Artery Disease 8 61
Renal Vascular Disease 8 10
 
Vascular Disorder of Kidney 8
Renal Vascular Disorder 61


Classifications:



External Ids:

Disease Ontology8 DOID:2388
NCIt39 C35338
ICD9CM27 593.81

Summaries for Renal Artery Disease

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MalaCards based summary: Renal Artery Disease, also known as renal vascular disease, is related to malignant hypertension and renovascular hypertension. An important gene associated with Renal Artery Disease is REN (renin), and among its related pathways are Angiogenesis and HIF1Alpha Pathway. The compounds remikiren and ibopamine have been mentioned in the context of this disorder. Affiliated tissues include kidney and heart, and related mouse phenotypes are muscle and liver/biliary system.

Related Diseases for Renal Artery Disease

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Diseases related to Renal Artery Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1malignant hypertension30.3REN, ACE
2renovascular hypertension29.7AGTR1, NPPA, ACE, REN
3hyperaldosteronism29.7REN, ACE, NPPA, AGTR1
4vascular disease29.6AGTR1, AGT, NOS3, ACE
5artery disease10.7
6fibromuscular dysplasia10.5REN
7hypoaldosteronism10.5REN
8congestive heart failure10.5REN
9mitral valve disease10.5NPPA
10orthostatic intolerance10.4AGTR1
11sick sinus syndrome10.4NPPA
12gitelman syndrome10.3REN, AGT
13oligohydramnios10.3ACE
14hypertensive encephalopathy10.3EPO
15hepatorenal syndrome10.3REN, NPPA
16conn's syndrome10.2REN, NPPA
17vesicoureteral reflux10.2AGTR1, AGT
18hypertension, diastolic10.2REN, ACE
19cor pulmonale10.2AGTR1, NPPA
20aortic valve disease 210.2NPPA, AGT
21renal hypertension10.2ACE, REN
22portal hypertension10.1NOS3, AGTR1
23nephrosclerosis10.1ACE, AGTR1
24end stage renal failure10.1
25neurofibromatosis10.1
26adrenal cortical adenoma10.1AGTR1, REN
27renal tubular dysgenesis10.1REN, AGT, AGTR1
28acute kidney failure10.1NPPA, REN
29renal fibrosis10.1REN, AGT, AGTR1
30hypokalemia10.1ACE, REN
31angioedema10.1AGT, ACE
32idiopathic edema10.1ACE, NPPA
33focal segmental glomerulosclerosis10.1ACE, AGTR1
34pulmonary fibrosis10.1AGTR1, AGT
35cerebrovascular disease10.1AGTR1, ACE
36autonomic neuropathy10.0EPO, REN
37pulmonary hypertension10.0NOS3, NPPA, AGT
38hyperinsulinism10.0NOS3, AGT, AGTR1
39obesity10.0
40neurofibromatosis, type 110.0
41neurofibromatosis, type 210.0
42retinitis10.0
43endotheliitis10.0
44iga glomerulonephritis10.0AGTR1, AGT, ACE
45peripheral vascular disease10.0
46polycystic kidney disease, autosomal dominant10.0REN, ACE, NOS3
47familial hyperlipidemia10.0AGTR1, AGT, ACE
48hypertensive heart disease10.0AGTR1, NPPA, ACE
49nephrotic syndrome9.9ACE, NPPA, AGT
50atrial fibrillation9.9AGTR1, NPPA, ACE

Graphical network of the top 20 diseases related to Renal Artery Disease:



Diseases related to renal artery disease

Symptoms for Renal Artery Disease

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Drugs & Therapeutics for Renal Artery Disease

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Drug clinical trials:

Search ClinicalTrials for Renal Artery Disease

Search NIH Clinical Center for Renal Artery Disease

Genetic Tests for Renal Artery Disease

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Anatomical Context for Renal Artery Disease

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MalaCards organs/tissues related to Renal Artery Disease:

31
Kidney, Heart

Animal Models for Renal Artery Disease or affiliated genes

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MGI Mouse Phenotypes related to Renal Artery Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3REN, NOS3, NPPA, AGT
2MP:00053708.2AGT, NOS3, ACE, EPO
3MP:00053788.1AGTR1, AGT, NOS3, ACE, REN
4MP:00053878.0REN, ACE, NOS3, AGT, AGTR1
5MP:00053677.7REN, ACE, NOS3, NPPA, AGT, AGTR1
6MP:00053977.6EPO, REN, ACE, NOS3, NPPA
7MP:00107687.4EPO, REN, ACE, NOS3, AGT, AGTR1
8MP:00053856.9AGTR1, EPO, REN, ACE, NOS3, NPPA
9MP:00053766.9EPO, REN, ACE, NOS3, NPPA, AGT

Publications for Renal Artery Disease

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Articles related to Renal Artery Disease:

(show all 24)
idTitleAuthorsYear
1
Ex vivo renal artery reconstruction for complex renal artery disease. (24594447)
2014
2
Prevalence of renal artery disease and its prognostic significance in patients undergoing coronary bypass grafting. (25150754)
2014
3
Our preoccupation with renal artery disease in patients undergoing cardiac surgery: much ado about nothing? (24161327)
2014
4
Long-term follow-up of patients with atherosclerotic renal artery disease. (23321402)
2013
5
MD CT angiography and MR angiography of nonatherosclerotic renal artery disease. (21681628)
2011
6
Vanishing renal artery disease: a segmental arterial mediolysis story. (21997510)
2011
7
Endovascular and open revascularization for nonatherosclerotic renal artery disease. (21249718)
2011
8
Atherosclerotic renal artery disease and heart failure: questions in mind. (20466691)
2010
9
Late outcomes of endovascular and open revascularization for nonatherosclerotic renal artery disease. (20855752)
2010
10
Update on the management of atherosclerotic renal artery disease. (19202521)
2009
11
Low frequency of renal artery disease in young ischemic stroke patients. (18564822)
2008
12
A multi-center, comparative, phase 3 study to determine the efficacy of gadofosveset-enhanced magnetic resonance angiography for evaluation of renal artery disease. (17499952)
2008
13
Atherosclerotic Peripheral Vascular Disease Symposium II: intervention for renal artery disease. (19106410)
2008
14
Relationship between coronary and renal artery disease and associated risk factors in hypertensive and diabetic patients undergoing coronary angiography. (19110812)
2008
15
Novel stent system for accurate placement in aorto-ostial renal artery disease: preclinical study in porcine renal artery model. (17574168)
2007
16
Usefulness of translesional pressure gradient and pharmacological provocation for the assessment of intermediate renal artery disease. (16892443)
2006
17
Clinical insights into the diagnosis and management of atherosclerotic renal artery disease. (16901412)
2006
18
Primary hyperaldosteronism: a frequent cause of residual hypertension after successful endovascular treatment of renal artery disease. (16208147)
2005
19
Surgical revascularization for renal artery disease: current status. (15720339)
2005
20
Factors predicting outcome in a cohort of patients with atherosclerotic renal artery disease diagnosed by magnetic resonance angiography. (16310572)
2005
21
Genetic risk of atherosclerotic renal artery disease: the candidate gene approach in a renal angiography cohort. (15326089)
2004
22
Effect of captopril on renal extraction of renin, angiotensin II, atrial natriuretic peptide and vasopressin, and renal vein renin ratio in patients with arterial hypertension and unilateral renal artery disease. (8272217)
1993
23
Effect of captopril on the renal veno-arterial gradient of erythropoietin and oxygen in unilateral renal artery disease. (8140397)
1993
24
The effect of caffeine on renal vein renin concentration in patients with renal arterial disease. (1815652)
1991

Variations for Renal Artery Disease

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Expression for genes affiliated with Renal Artery Disease

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Search GEO for disease gene expression data for Renal Artery Disease.

Pathways for genes affiliated with Renal Artery Disease

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Pathways related to Renal Artery Disease according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6NOS3, REN
29.1EPO, NOS3
3
Show member pathways
9.1AGT, ACE, REN
4
Show member pathways
8.8AGTR1, AGT, EPO
5
Show member pathways
Development EDNRB signaling59
Development ACM2 and ACM4 activation of ERK59
Cell adhesion Integrin inside out signaling59
Development G Proteins mediated regulation MARK ERK signaling59
Signal transduction IP3 signaling59
Development Angiotensin signaling via PYK259
Development EPO induced MAPK pathway59
8.7AGTR1, NOS3, EPO
6
Show member pathways
8.6REN, ACE, AGT, AGTR1
78.6EPO, NOS3, NPPA
8
Show member pathways
8.1AGTR1, AGT, NOS3, ACE, REN

Compounds for genes affiliated with Renal Artery Disease

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Compounds related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1remikiren44 1110.4ACE, AGT, REN
2ibopamine449.3NPPA, ACE, REN
3lacidipine449.2REN, AGTR1, ACE
4alacepril449.2NPPA, REN, ACE
5aliskiren44 1110.0REN, ACE, AGT, AGTR1
6saralasin449.0AGT, AGTR1, ACE, REN
7eprosartan44 28 1111.0AGTR1, AGT, ACE, REN
8olmesartan44 28 1111.0AGT, REN, ACE, AGTR1
9chymostatin449.0REN, ACE, AGT, AGTR1
10valsartan44 60 28 1112.0REN, AGTR1, AGT, ACE
11telmisartan44 28 1111.0ACE, AGT, AGTR1, REN
12atenolol44 50 28 24 1113.0AGTR1, AGT, REN, ACE
13irbesartan44 28 50 1112.0AGT, AGTR1, ACE, REN
14bisoprolol44 50 1111.0REN, NPPA, ACE
15omapatrilat449.0ACE, REN, NPPA
16enalaprilat448.9AGT, REN, ACE, NPPA
17diltiazem44 28 50 1111.9REN, AGTR1, AGT, ACE
18hydrochlorothiazide44 28 50 24 1112.9REN, AGTR1, AGT, ACE
19cilazapril44 119.9ACE, REN, NPPA, AGTR1
20trandolapril44 119.9AGTR1, NPPA, ACE, REN
21fosinopril44 119.9ACE, AGTR1, NPPA, REN
22quinapril44 50 1110.9ACE, NPPA, AGTR1, REN
23ramipril44 119.9REN, ACE, NPPA, AGTR1
24felodipine44 28 1110.9AGTR1, NPPA, ACE, REN
25metoprolol44 50 28 24 1112.8REN, NOS3, NPPA, ACE
26spironolactone44 60 28 50 1112.8AGTR1, NPPA, ACE, REN
27l-nmma448.8NOS3, AGTR1, NPPA, AGT
28digoxin44 60 50 24 1112.8AGTR1, ACE, REN, NPPA
29furosemide44 60 28 50 24 1113.7REN, AGTR1, NPPA, ACE
30pd12331944 289.7AGT, AGTR1, ACE
31phenylephrine44 28 24 1111.7AGT, NOS3, AGTR1, NPPA
32fludrocortisone44 28 1110.7REN, NPPA, EPO
33benazepril44 50 1110.5NPPA, REN, AGTR1, AGT, ACE
34lisinopril44 50 24 1111.5AGTR1, AGT, NPPA, ACE, REN
35candesartan44 50 28 1111.5REN, ACE, AGT, NOS3, AGTR1
36cgmp44 289.5NPPA, AGT, NOS3, AGTR1, REN
37captopril44 60 50 28 1112.5AGTR1, REN, NPPA, ACE, AGT
38losartan44 50 28 1111.5REN, ACE, NPPA, AGT, AGTR1
39nifedipine44 28 50 1111.4NPPA, AGTR1, AGT, ACE, REN
40carvedilol44 50 28 1111.4AGTR1, REN, ACE, NOS3, NPPA
41nitroglycerin44 119.4REN, ACE, NOS3, NPPA, AGTR1
42norepinephrine44 24 1110.2ACE, REN, NPPA, AGT, AGTR1
43ang ii448.0ACE, REN, NPPA, NOS3, AGT, AGTR1
44perindopril44 50 1110.0ACE, NOS3, NPPA, AGT, AGTR1, REN
45amlodipine44 50 24 1111.0REN, ACE, NPPA, AGT, NOS3, AGTR1
46prostacyclin448.0REN, AGTR1, ACE, NOS3, AGT, NPPA
47nitric oxide44 24 119.7ACE, REN, NPPA, AGTR1, AGT, NOS3
48enalapril44 50 119.7AGTR1, AGT, NPPA, ACE, EPO, REN
49creatinine447.6REN, ACE, NPPA, AGT, AGTR1, EPO
50vegf447.5NPPA, REN, AGTR1, EPO, NOS3, AGT

GO Terms for genes affiliated with Renal Artery Disease

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Cellular components related to Renal Artery Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7REN, ACE, NPPA, AGT, EPO
2extracellular spaceGO:00056157.4AGT, NPPA, ACE, REN, EPO

Biological processes related to Renal Artery Disease according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of NAD(P)H oxidase activityGO:00338649.9AGT, AGTR1
2regulation of blood vessel size by renin-angiotensinGO:00020349.9AGT, AGTR1
3regulation of renal sodium excretionGO:00358139.9AGTR1, AGT
4positive regulation of cholesterol esterificationGO:00108739.9AGT, AGTR1
5low-density lipoprotein particle remodelingGO:00343749.9AGTR1, AGT
6positive regulation of cellular protein metabolic processGO:00322709.9AGTR1, AGT
7positive regulation of macrophage derived foam cell differentiationGO:00107449.8AGT, AGTR1
8regulation of renal output by angiotensinGO:00020199.8ACE, AGT
9positive regulation of reactive oxygen species metabolic processGO:020003799.7AGTR1, AGT
10nitric oxide mediated signal transductionGO:00072639.7NOS3, AGT
11regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.7AGTR1, ACE
12phospholipase C-activating G-protein coupled receptor signaling pathwayGO:00072009.7AGTR1, AGT
13regulation of vasodilationGO:00423129.7AGTR1, ACE
14regulation of blood vessel sizeGO:00508809.7NPPA, NOS3
15positive regulation of inflammatory responseGO:00507299.6AGT, AGTR1
16renin-angiotensin regulation of aldosterone productionGO:00020189.6REN, AGT, AGTR1
17response to salt stressGO:00096519.4EPO, AGT
18cellular response to mechanical stimulusGO:00712609.4AGT, NPPA
19angiotensin maturationGO:00020039.4AGT, ACE, REN
20regulation of vasoconstrictionGO:00192299.3AGTR1, ACE, AGT
21regulation of cell growthGO:00015589.3AGTR1, AGT
22blood vessel remodelingGO:00019749.3AGT, ACE, NOS3
23cellular protein metabolic processGO:00442679.1REN, AGT, ACE
24kidney developmentGO:00018229.0ACE, AGT, REN, AGTR1
25regulation of blood pressureGO:00082178.8NOS3, NPPA, REN, ACE

Molecular functions related to Renal Artery Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:00317119.1AGTR1, ACE
2hormone activityGO:00051798.7AGT, NPPA, EPO

Sources for Renal Artery Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet