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RCC
MCID: RNL014

Renal Cell Carcinoma malady
24 drugs, 1055 genes, 30 tissues, 1778 related diseases, 29 phenotypes, 2182 articles, clinical trials.

Summaries for Renal Cell Carcinoma

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44Wikipedia, 33OMIM, 22MalaCards
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Wikipedia: Renal cell carcinoma (RCC, also known as hypernephroma) is a kidney cancer that originates in the lining...44 more...

MalaCards: Renal Cell Carcinoma, also known as conventional (clear cell) renal cell carcinoma, is related to carcinoma and prostatitis. An important gene associated with Renal Cell Carcinoma is PRCC (papillary renal cell carcinoma (translocation-associated)), and among its related pathways are ERK Signaling and Cellular Apoptosis Pathway. The drugs carmustine and interferon alfa-2b,recombinant and the compounds calcium and paraffin have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and spleen, and related mouse phenotypes are homeostasis/metabolism and cellular.

OMIM: 144700

Aliases & Descriptions for Renal Cell Carcinoma

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43UMLS, 6Disease Ontology, 7diseasecard, 8DISEASES, 33OMIM, 32Novoseek , 40SNOMED-CT, 24MeSH, 27NCIt
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Aliases & Descriptions:

renal cell carcinoma 6 7 8 33 43
conventional (clear cell) renal cell carcinoma 43
renal cell carcinoma (morphologic abnormality) 6
renal cell carcinoma, stage unspecified 6
adenocarcinoma of kidney 6
hypernephroma (disorder) 6
carcinoma renal cell 32
adenocarcinoma 43
carcinoma 43
rcc 6

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NCIt27 C9385

Related Diseases for Renal Cell Carcinoma

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13GeneCards, 14GeneDecks
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Disease types for renal cell carcinoma family:

renal cell carcinoma 4

Diseases related to renal cell carcinoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1774)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma213.7ZNF608, ZNF673, ZNF354A, ZNF202, PIK3CB, PIK3CD
2prostatitis145.4ZNF608, ZNF673, PIK3CB, PIK3CD, PIK3CA, PIK3R3
3leukemia129.9ZNF673, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
4pancreatitis124.9PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5melanoma123.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
6adenocarcinoma119.6PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
7neuronitis118.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8colorectal cancer117.1PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
9hepatocellular carcinoma116.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, KL
10ovarian cancer110.8ZNF673, ZNF354A, PIK3CB, PIK3CD, PIK3CA, PIK3R3
11esophagitis110.2ZNF673, PIK3CB, PIK3CA, PIK3C2A, PIK3CG, NCAM1
12thyroiditis109.9PIK3CB, PIGF, PIK3CA, PIK3R1, PIK3C2A, PIK3CG
13gastric cancer107.7PIK3CB, PIK3CA, PIK3R1, PIK3CG, RELA, KIT
14hypoxia104.6ZNF354A, PIK3CB, PIK3CD, PIGF, PIK3CA, PIK3R1
15cervicitis102.1PIK3CA, PIK3CG, LRIG1, KL, PDCD1, RELA
16colon cancer99.3PIK3CB, PIK3CA, PIK3R3, PIK3R1, PIK3CG, NCAM1
17breast carcinoma96.8ZNF202, PIK3CA, PIK3R1, PIK3CG, LRP1, KIT
18sarcoma93.5PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
19neuroblastoma91.2PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
20arthritis89.1PIK3CD, PIK3CG, LRP1, KL, PDCD1, RELA
21adenoma88.4PIK3CA, NCAM1, NCOA1, CNR1, KIT, KISS1
22ovarian carcinoma88.2PIGF, PIK3CA, PIK3CG, RELA, KIT, KISS1
23rheumatoid arthritis83.3PIK3CD, PIK3CG, LRP1, KL, PDCD1, RELA
24fibrosis82.7PIK3CA, PIK3CG, LRP1, KL, RELA, CNR1
25myeloma80.3PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, NCAM1
26cervical cancer79.8PIK3CA, PIK3CG, LRIG1, PDCD1, RELA, KIAA1524
27retinitis79.3PIGF, PIK3CA, PIK3C2A, PIK3CG, LRP1, SGCB
28cerebritis78.0PIGF, PIK3R1, PIK3C2A, PIK3CG, LRP1, NCAM1
29clear cell renal cell carcinoma78.0LRRC2, RELA, KIT, SFRP1, BTG2, SETD2
30myeloid leukemia77.6ZNF673, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
31lung carcinoma76.6PIK3CA, PIK3R1, PIK3CG, NCAM1, PCNA, BTG2
32alzheimer's disease76.3PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3CG, LRP1
33lung adenocarcinoma75.8PIK3CA, PIK3CG, LRP1, PCNA, RB1, SELE
34colon carcinoma74.9PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, KL
35lymphocytic leukemia74.5PIK3CD, PIK3CA, PIK3CG, NCAM1, RELA, KIT
36cholesterol73.5ZNF202, PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1
37laryngitis73.2PIK3CA, RELA, KIR3DL1, PCNA, BTG2, RB1
38hypertension72.9PIK3CB, PIK3R1, PIK3C2A, PIK3CG, LRP1, KL
39esophageal squamous cell carcinoma72.4ZNF673, PIK3CA, NCAM1, RELA, KIT, KISS1
40multiple myeloma72.0PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, NCAM1
41oral squamous cell carcinoma70.7PIK3CA, PIK3C2A, PDCD1, SFRP1, SFRP2, PCNA
42astrocytoma70.0PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, RELA
43osteosarcoma69.4PIK3CB, PIK3CA, PIK3CG, NCOA1, RELA, CNR1
44ischemia69.0ZNF354A, PIGF, PIK3CA, PIK3C2A, PIK3CG, NCAM1
45endometrial carcinoma68.7PIK3CB, PIK3CA, PIK3C2A, PIK3CG, LRP1, NCOA1
46renal carcinoma68.5ZNF608, PIK3CG, NCOA1, KIF21A, PCNA, GCC2
47acute myeloid leukemia68.3ZNF673, PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2
48nasopharyngitis68.1PIK3CA, PIK3CG, PDCD1, RELA, KIT, KIR2DL3
49peritonitis67.6PIK3C2A, LRP1, RELA, KIT, KIR2DL3, KITLG
50esophageal cancer66.4PIK3CB, PIK3CA, PIK3CG, CNR1, KITLG, SFRP1

Graphical network of the top 20 diseases related to renal cell carcinoma:



Graphical network of diseases related to renal cell carcinoma

Clinical Features for Renal Cell Carcinoma

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33OMIM
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Clinical features from OMIM: 144700

Drugs & Therapeutics for Renal Cell Carcinoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for renal cell carcinoma

Drug clinical trials:

Search ClinicalTrials for renal cell carcinoma

Search NIH Clinical Center for renal cell carcinoma

Search CenterWatch for renal cell carcinoma

Inferred drug relations via UMLS/NDF-RT:

43 28 aldesleukin, carmustine, diethylstilbestrol, diethylstilbestrol diphosphate, hydroxyurea, interferon, interferon alfa 2-b, interferon alfa-2a, interferon alfa-2a,recombinant, interferon alfa-2b, interferon alfa-2b,recombinant, interferon alfa-3n,human leukocyte derived, interferon alfacon-1, interferon beta-1a,recombinant, interferon beta-1b,recombinant, interferon gamma-1b, medroxyprogesterone, medroxyprogesterone acetate, mitomycin, nilutamide, peginterferon alfa-2a, peginterferon alfa-2b, thalidomide, thiotepa

Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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22MalaCards
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MalaCards organs/tissues related to renal cell carcinoma:

22
Whole blood, Lymph node, Spleen, Brain, Cortex, Smooth muscle, Small intestine, Kidney, Liver, Lung, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Placenta, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Adrenal cortex

Phenotypes for genes affiliated with Renal Cell Carcinoma

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25MGI
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MGI Mouse Phenotypes related to renal cell carcinoma:

25 (show all 29)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1homeostasis/metabolism phenotypeMP:000537659.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3C2A
2cellular phenotypeMP:000538454.7PIK3CB, PIK3CD, PIK3CA, PIK3R1, PIK3R5, PIK3CG
3mortality/agingMP:001076851.1PIK3CB, PIK3CA, PIK3C2A, LRP1, KL, NCAM1
4growth/size phenotypeMP:000537847.6PIK3CB, PIK3CA, PIK3R1, PIK3C2A, PIK3CG, LRP1
5cardiovascular system phenotypeMP:000538544.9PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
6nervous system phenotypeMP:000363137.1LRIG1, LRP1, KL, NCOA1, PDCD1, RELA
7behavior/neurological phenotypeMP:000538634.7PIK3CA, LRP1, KL, NCAM1, NCOA1, CNR1
8hematopoietic system phenotypeMP:000539734.7PDCD1, KIT, KISS1R, VTCN1, SFRP1, PCNA
9tumorigenesisMP:000200634.1PIK3CB, PIK3CA, PIK3R2, PIK3R1, LRIG1, KIT
10normal phenotypeMP:000287332.7PIK3R1, LRIG1, LRP1, RELA, KISS1R, VTCN1
11reproductive system phenotypeMP:000538931.3PIK3CA, NCOA1, KISS1, KISS1R, SF1, SFRP2
12integument phenotypeMP:001077131.2PIK3CG, LRIG1, KL, NCOA1, RELA, CNR1
13muscle phenotypeMP:000536930.2PIK3CA, PIK3R2, PIK3R1, PIK3CG, LRP1, KL
14vision/eye phenotypeMP:000539130.1PIK3CA, NCAM1, PDCD1, RELA, KIT, KITLG
15skeleton phenotypeMP:000539027.8PIK3CD, PIK3CG, LRP1, NCOA1, RELA, CNR1
16embryogenesis phenotypeMP:000538026.8PIK3CB, PIK3CA, NCOA1, KIT, SFRP1, SFRP2
17renal/urinary system phenotypeMP:000536725.5KL, NCOA1, PDCD1, KIT, KISS1, KISS1R
18adipose tissue phenotypeMP:000537521.4PIK3CA, PIK3R1, PIK3C2A, LRP1, KL, CNR1
19no phenotypic analysisMP:000301220.8PIK3CD, PIK3R1, CNR1, SFRP1, SFRP2, PCNA
20limbs/digits/tail phenotypeMP:000537120.4LRIG1, KL, RELA, KIT, KITLG, SFRP1
21endocrine/exocrine gland phenotypeMP:000537919.8LRIG1, KL, NCOA1, KISS1, KISS1R, SF1
22hearing/vestibular/ear phenotypeMP:000537719.3KIT, KITLG, RB1, NAGLU, VDR, LMNA
23craniofacial phenotypeMP:000538218.5LRIG1, KIT, KITLG, NBN, NAGLU, MYO6
24pigmentation phenotypeMP:000118615.3KIT, KITLG, RB1, RBPJ, SERPINF1, NAGLU
25other phenotypeMP:000539514.4KL, CNR1, RARA, RARB, CLU, KDR
26respiratory system phenotypeMP:000538814.2KL, RBPJ, SELL, SELP, BMPR2, PBRM1
27liver/biliary system phenotypeMP:000537013.7KIT, VHL, VEGFA, MET, IL2, IL6
28immune system phenotypeMP:0005387INFPIK3CD, PIK3R5, LRP1, KL, NCOA1, SGCB
29digestive/alimentary phenotypeMP:0005381INFLRIG1, KL, KIT, KISS1, KITLG, KISS1R

Publications for genes affiliated with Renal Cell Carcinoma

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35PubMed
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Articles related to renal cell carcinoma:

(show top 50)    (show all 2182)
idTitleAuthorsYearAffiliating Genes
1Clear cell papillary renal cell carcinoma and clear c ell renal cell carcinoma arising in acquired cystic disease of the kidney: an i mmunohistochemical and genetic study. (20952286)Kuroda N.... Pan C.C.2011VHL
2Combination therapy of interleukin-2 and sorafenib im proves survival benefits and prevents spontaneous pulmonary metastasis in murin e renal cell carcinoma models. (20106881)Amagai Y.... Abe K.2010IL2
3IL-16 polymorphism and risk of renal cell carcinoma: association in a Chinese population. (20529140)Zhu J.... Yin C.2010IL16
4Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma. (20572163)Zhu J.... Yin C.2010CASP8, FAS, FASLG
5Upregulation of GRP78 in renal cell carcinoma and its significance. (19616278)Fu W.... Ding Q.2010HSPA5
6MYC pathway is activated in clear cell renal cell carcinoma and essential for proliferation of clear cell renal cell carcinoma cells. (18809243)Tang S.W.... Lin J.Y.2009PGK1, MYC
7Effect of temsirolimus versus interferon-alpha on outcome of patients with advanced renal cell carcinoma of different tumor histologies. (19229667)Dutcher J.P.... Hudes G.2009IFNA1
8Fas-induced apoptosis of renal cell carcinoma is medi ated by apoptosis signal-regulating kinase 1 via mitochondrial damage-dependent caspase-8 activation. (19940360)Hassan M.... Grinstein E.2009MAPK8, MAPK14, FAS
9Systemic therapy of metastatic renal cell carcinoma: from many options to the therapeutic strategy (19806342)Ringhoffer M.... Greiner J.2009MTOR
10Expression of erythropoietin and its receptor in huma n renal cell carcinoma. (19407488)Papworth K.... Rasmuson T.2009EPOR, EPO
11The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker. (18685487)Gokden N.... McKenney J.K.2008PAX2, MOK
12Useful markers for differential diagnosis of oncocytoma, chromophobe renal cell carcinoma and conventional renal cell carcinoma. (18603673)Geramizadeh B.... Rahsaz M.2008VIM, MME, MUC1
13Phase II study of combination thalidomide/interleukin-2 therapy plus granulocyte macrophage-colony stimulating factor in patients with metastatic renal cell carcinoma. (18525301)Amato R.J.... Rawat A.2008IL2
14Multidrug resistance proteins in renal cell carcinoma. (19393132)HodorovA! I.... KluchovA! D.2008LRP1, ABCC1, ABCB1
15High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT-PCR mRNA expression profile. (17505508)Baldewijns M.M.... Vermeulen P.B.2007CA9
16Immunohistochemical expression of vascular endothelial growth factor (VEGF) does not correlate with microvessel density in renal cell carcinoma. (17822316)Raica M.... Anghel A.2007VEGFA, ENG, PECAM1
17Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. (17908959)Morikawa T.... Aburatani H.2007TLR3
18Immunohistochemical analysis of chromophobe renal cell carcinoma, renal oncocytoma, and clear cell carcinoma: an optimal and practical panel for differential diagnosis. (17683191)Liu L.... Bostwick D.G.2007KIT, VIM, KRT7
19HLA-G as a target molecule in specific immunotherapy against renal cell carcinoma. (17982631)Komohara Y.... Itoh K.2007HLA-G
20Metastasis from papillary renal cell carcinoma masquerading as primary ovarian clear cell tumor. (17905525)Stolnicu S.... Nogales F.F.2007AMACR
21Present strategies in the treatment of metastatic renal cell carcinoma: an update on molecular targeting agents. (17092282)Bellmunt J.... Orsola A.2007MTOR
22Muscle and small intestinal metastasis of renal cell carcinoma markedly responsive to interferon-alpha therapy: a case report. (17933140)Sano F.... Kitami K.2007IFNA1
23Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma. (16964377)Hirota E.... Katagiri T.2006SEMA5B
24Expression of renal cell carcinoma-associated markers erythropoietin, CD10, and renal cell carcinoma marker in diffuse malignant mesothelioma and metastatic renal cell carcinoma. (16740034)Butnor K.J.... Cagle P.T.2006MME
25Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. (16510593)Krishnamachary B.... Semenza G.L.2006CDH1, VHL, SETD2
26Interferon-alpha plus capecitabine and thalidomide in patients with metastatic renal cell carcinoma: a pilot study. (16086096)Amato R.J.... Rawat A.2006IFNA1
27Interleukin-2, interferon-alpha and 5-fluorouracil immunotherapy for metastatic renal cell carcinoma: the all Ireland experience. (15082204)O'Brien M.F.... Thornhill J.2004IL2, IFNA1
28Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. (14961590)Nagy A.... Kovacs G.2004FLCN
29Renal cell carcinoma bone metastasis: epidermal growth factor receptor targeting. (14600596)Weber K.L.... Price J.E.2003EGFR
30Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma. (11957150)Ikeda R.... Suzuki K.2002PCNA
31Expression of CD44 protein in renal cell carcinomas: association with p53 expression. (12474536)Zolota V.... Scopa C.2002CD44
32Histopathologic analysis of angiogenic factors in localized renal cell carcinoma: the influence of neoadjuvant treatment. (11389742)Kawata N.... Takimoto Y.2001TYMP
33Sequential administration of interferon gamma and interleukin-2 in metastatic renal cell carcinoma: results of a phase II trial. Austrian Renal Cell Carcinoma Study Group. (10999466)Schmidinger M.... Zielinski C.C.2000IFNG
34Tumor M2 pyruvate kinase in renal cell carcinoma. Studies of plasma in patients (11138278)Roigas J.... Loening S.A.2000PKM
35Pathology and proliferative activity of renal-cell carcinomas (RCCS) and renal oncocytomas in patients with different radiation exposure after the Chernobyl accident in Ukraine. (10956401)Romanenko A.... Llombart-Bosch A.2000PCNA
36Intranuclear localization of proliferating cell nuclear antigen during the cell cycle in renal cell carcinoma. (10800611)Kawamura K.... Suzuki K.2000PCNA
37GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. (14606586)North P.E.... Mrak R.E.2000SLC2A1
38Protein kinase C in human renal cell carcinomas: role in invasion and differential isoenzyme expression. (10737390)Engers R.... Gabbert H.E.2000DYT10
39Cytotoxicity of adenoviral-mediated cytosine deaminase plus 5-fluorocytosine gene therapy is superior to thymidine kinase plus acyclovir in a human renal cell carcinoma model. (10458414)Shirakawa T.... Kao C.1999GJA1, TKT
40The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8. (9689122)Gemmill R.M.... Drabkin H.A.1998FHIT, RNF139
41Epidermal growth factor family and renal cell carcinoma: expression and prognostic impact. (9187911)Hofmockel G.... DAommrich J.1997EGF
42Altered expression of transforming growth factor-alpha: an early event in renal cell carcinoma development. (9254888)Everitt J.I.... Wolf D.C.1997EGFR, TGFA
43Transforming growth factor-alpha expression in human renal cell carcinoma: TGF-alpha expression in renal cell carcinoma. (8560658)Hise M.K.... Drachenberg C.I.1996TGFA
44Impaired production of interferon-alpha in whole-blood cultures from patients with renal cell carcinoma. (8653314)Kuo J.Y.... Yoshida O.1996IFNA1
45Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma. (8600309)Selvanayagam P.... Rajaraman S.1996MT-ND3
46Tenascin and fibronectin isoforms in human renal cell carcinomas, renal cell carcinoma cell lines and xenografts in nude mice. (7591246)Lohi J.... Virtanen I.1995FN1, TNC
47Basic fibroblast growth factor (FGF-2) in renal cell carcinoma, which is indistinguishable from that in normal kidney, is involved in renal cell carcinoma growth. (7523715)Emoto N.... Toma H.1994FGF2
48Bellini duct carcinoma: further evidence for this rare variant of renal cell carcinoma. (1707029)Rumpelt H.J.... Thoenes W.1991VIM, KRT13
49Study on adoptive immunotherapy on patients with renal cell carcinoma. I. Functional characteristics of peripheral blood mononuclear cells and serum immunosuppressive factors in patients with renal cell carcinoma (2214468)Usui A.1990IL2, IL2RB
50Clinical effects and immunological changes in interf eron therapy for advanced renal cell carcinoma (2109026)Kudo T.... Suzuki T.1990IFNG

Expression for genes affiliated with Renal Cell Carcinoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Pathways for genes affiliated with Renal Cell Carcinoma

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36QIAGEN, 20KEGG, 38Reactome, 41Thomson Reuters, 10EMD Millipore, 34PharmGKB
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Pathways related to renal cell carcinoma according to GeneDecks:

(show top 50)    (show all 390)
idPathwayScoreTop Affiliating Genes
1ERK Signaling3622.3PIK3R3, PIK3R2, PIK3R1, KIT, KITLG, SEMA4G
2Cellular Apoptosis Pathway3619.7PIK3R3, PIK3R2, PIK3R1, KIT, KITLG, SEMA4G
3p53 Mediated Apoptosis3618.4PIK3R3, PIK3R2, PIK3R1, KIT, KITLG, SEMA4G
4Estrogen Pathway3618.0PIK3R3, PIK3R2, PIK3R1, NCOA1, KIT, KITLG
5Rac1 Pathway3616.7PIK3R3, PIK3R2, PIK3R1, KITLG, SEMA4G, VEGFB
6IL-6 Pathway3616.5PIK3R3, PIK3R2, PIK3R1, BRAF, BMP6, BMP7
7Prostate cancer2016.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
8Rap1 Pathway3616.4KITLG, SEMA4G, BRAF, VEGFB, VEGFC, BMP6
9Immune System3815.9NCAM1, PDCD1, KIR2DL3, KIR3DL1, VCAM1, RAP1GAP
10Glucocorticoid Receptor Signaling3615.6NCOA1, BMP6, BMP7, BCL2, BAX, CEBPB
11Tuberculosis2015.6RELA, VDR, RAF1, BCL2, CIITA, BAD
12MAPK signaling pathway2015.3RELA, BRAF, MYC, RAP1A, RAF1, RAP1B
13Development_IGF-1 receptor signaling4115.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
14P2Y Receptor Signaling3615.2PIK3R3, PIK3R2, PIK3R1, KIT, BRAF, VEGFB
15FAK1 Signaling3614.8PIK3R3, PIK3R2, PIK3R1, BRAF, VCL, RAF1
16Glioma2014.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
17Integrin Pathway3614.6PIK3R3, PIK3R2, PIK3R1, BRAF, VCL, MYC
18Hematopoietic cell lineage2014.3KIT, KITLG, CD24, CD3G, CD34, CD1A
19Insulin signaling pathway2014.0PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
20Leukocyte transendothelial migration2013.9PIK3CB, PIK3CD, PIK3R3, PIK3R2, PIK3R1, PIK3R5
21Development PDGF signaling via STATs and NF-kB1013.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
22Signaling Involved in Cardiac Hypertrophy3613.6PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, RAC1
23Immune response_IL-4 signaling pathway4113.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
24HIF1Alpha Pathway3613.5NCOA1, RBX1, VHL, VEGFB, VEGFC, LDHA
25Cell adhesion_PLAU signaling4113.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
26Apoptosis and survival Apoptotic TNF-family pathways1013.3BIRC2, BCL2, BCL2L1, BAX, XIAP, CD27
27Development_Prolactin receptor signaling4113.3PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RELA
28IL-4 Pathway3613.2PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BCL2
29Development_EGFR signaling pathway4113.1PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, MYC
30Apoptosis and survival FAS signaling cascades1012.9LMNA, BIRC2, PARP1, PAK2, BCL2, BCL2L11
31Immune response IL-9 signaling pathway1012.8PIK3CB, PIK3CD, PIK3R3, PIK3R2, RELA, RAF1
32Apoptosis and survival_FAS signaling cascades4112.8LMNA, BIRC2, PARP1, PAK2, BCL2, BCL2L11
33IL-3 Pathway3612.7PIK3R3, PIK3R2, PIK3R1, BRAF, RAF1, BCL2L1
34Cytoskeleton remodeling_Integrin outside-in signaling4112.7VCL, RAF1, RAC1, LIMS1, PAK1, JUN
35Development Neurotrophin family signaling1012.7PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
36Development HGF signaling pathway1012.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
37Development Endothelin-1/EDNRA transactivation of EGFR1012.6PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
38Development EPO-induced Jak-STAT pathway1012.5MYC, RAF1, BCL2, BCL2L1, XIAP, JAK2
39Development Endothelin-1/EDNRA signaling1012.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
40TCR Signaling3612.5PIK3R3, PIK3R2, PIK3R1, RAF1, RAC1, PAK1
41Development A2A receptor signaling1012.5PIK3CB, PIK3CD, PIK3CA, RELA, BRAF, RAP1A
42Development Flt3 signaling1012.4PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, RAF1
43Sorafenib Pharmacodynamics3412.4PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3C2A
44Development_VEGF signaling and activation4112.3PIK3CB, PIK3CA, PIK3R3, PIK3R2, RELA, SELE
45Immune response_IFN gamma signaling pathway4112.3PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
46Immune response_IL-6 signaling pathway4112.0RELA, RAF1, CEBPB, JUN, JAK1, FOS
47Signal transduction_PTEN pathway4111.7PCNA, ITGB1, IGF1R, CASP9, TSC2, PXN
48EGFR Inhibitor Pathway, Pharmacodynamics3411.2HRAS, NRAS, NFKB2, KRAS, STAT5B
49Apoptosis and survival_Anti-apoptotic action of nuclear ESR1 and ESR24111.1RELA, MYC, RAF1, BCL2, BAX, JUN
50Immune response_Oncostatin M signaling via MAPK in human cells4111.0RAF1, RAC1, LDLR, CEBPB, JUN, JAK1

Compounds for genes affiliated with Renal Cell Carcinoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to renal cell carcinoma according to GeneDecks:

(show top 50)    (show all 398)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 46.6PIK3CD, PIK3C2A, LRP1, KL, RELA, SGCB
2paraffin32 32.5NCAM1, RELA, KIT, KITLG, PCNA, RB1
3thymidine32 18 33.1PIK3CA, PIK3R1, KIT, KITLG, PCNA, RB1
4nitric oxide32 9 18 9 34.8PIK3CB, PIGF, NCAM1, SGCB, KIT, KITLG
5atp32 30.9ZNF202, PIK3CB, PIK3CA, PIK3C2A, NCAM1, SGCB
6cholesterol32 9 18 9 31.1ZNF202, PIK3CB, PIK3CA, PIK3R1, PIK3C2A, LRP1
7pd 98,05932 24.7PIK3CA, PIK3R1, PIK3CG, KIT, KITLG, RB1
8glucose32 22.6KIT, KISS1, SETD2, SERPINF1, BRAF, VHL
9proline32 22.0PIK3R1, KISS1R, SETD2, VIM, BSG, VHL
10iron32 18 22.1PIK3C2A, SGCB, KITLG, SETD2, VIM, NAGLU
11indomethacin32 9 9 22.1NCOA1, CNR1, PCNA, SELL, VIM, MYC
12estradiol32 9 18 9 22.5NCOA1, KITLG, PCNA, RB1, SERPINE1, VIM
13adriamycin32 18.6RB1, VIM, VDR, MYC, BIRC2, BIRC3
14calcitriol32 42 9 18 9 22.3PIK3CB, NCOA1, KITLG, RB1, VDR, MYC
15ascorbic acid32 18 19.2PIK3CG, SGCB, PCNA, SETD2, SERPINB2, NAT1
16retinoid32 18.0NCOA1, SELL, VIM, VDR, MYC, BMP6
17aspartate32 17.8PIK3R1, PIK3C2A, CNR1, PCNA, SELP, VIM
18sodium32 18 18.7PIK3CA, PIK3C2A, NCAM1, SGCB, NAGLU, BRAF
19methionine32 17.6KIT, SERPINF1, SERPINB2, VIM, VCL, RASSF1
20phosphotyrosine32 17.4PIK3CB, PIK3CA, PIK3R1, PIK3CG, KIT, KIR3DL1
21folate32 16.8SELE, VIM, NAT1, NAT2, VHL, VDR
22docetaxel32 34 9 9 19.8KIT, SETD2, VEGFA, VDR, MYC, RAF1
23chloramphenicol32 9 9 18.3SELE, SETD2, SERPINE1, VIM, VDR, MYC
24gold32 16.3PIK3C2A, KIT, KITLG, NAGLU, BRAF, VCL
25camptothecin32 42 9 9 19.1PIK3CG, PCNA, RB1, NBN, SETD2, MYC
26azathioprine32 34 9 9 19.0PCNA, VIM, RARB, RASSF1, RAC1, CHKB
27norepinephrine32 9 18 9 18.9PIK3C2A, CNR1, KITLG, SELE, SELL, SELP
28cytochalasin d32 42 16.9PIK3CG, KITLG, SELE, SELL, VIM, VCAM1
29hematoxylin32 15.7NCAM1, KIT, PCNA, VIM, LGALS3, MUC1
30histidine32 15.5KITLG, VHL, RARA, KHDRBS1, KCNH2, LGALS1
31dihydrotestosterone32 9 18 9 18.2NCOA1, SETD2, SERPINE1, VIM, VDR, BMP6
32chloroquine32 34 9 9 17.4KIT, BMP6, RAF1, KCNH2, CIITA, LDLR
33rosiglitazone32 9 18 9 17.4PIK3CA, PIK3CG, LRP1, NCOA1, SELE, SERPINE1
34allergens32 14.3PDCD1, LGALS3, CIITA, CD79A, CD40LG, CD80
35daunorubicin32 9 9 16.2RELA, KITLG, MYC, RAF1, BIRC5, BCL2
365-hydroxytryptamine32 14.0SGCB, CNR1, SERPINE1, VIM, BMP6, RAF1
37ccl432 14.0S100B, MMP13, MET, IL12B, IL13, IL16
38ceramide32 13.9PIK3CA, PIK3R1, CNR1, RB1, RAF1, PAWR
39nadph32 18 14.7PIK3CA, SGCB, PAK1, SDHB, XRCC1, XPC
40manganese superoxide32 13.7SERPINB2, VCAM1, BCL2L1, XRCC1, CD40, FOXO1
41homocysteine32 18 14.5PIK3C2A, SELE, SELP, SERPINE1, NAGLU, NAT1
42cytochalasin b32 13.3VIM, BSG, VCL, BIRC5, BCR, MPO
43mevalonate32 13.2SERPINE1, VCAM1, RAP1A, RAC1, BCL2L1, LDLR
44alpha tocopherol32 13.0VCAM1, RARB, PAK2, SCARB1, LEP, CHKB
45ibuprofen32 9 18 9 15.8VCAM1, BMP6, LEP, CHUK, MMP1, MMP2
46vincristine32 34 9 9 15.5NCAM1, KIT, UGCG, CGB, FGF2, ANXA5
47ciglitazone32 12.3SERPINE1, RARA, RARB, PARP1, BCL2L1, BAX
48c2ceramide32 12.0PIK3CG, PARP1, BCL2L1, CHUK, UGCG, BAX
49ndga32 11.8VCAM1, JUN, MMP13, MMP3, FOS, IL1B
50tpck32 11.6PIK3CG, PARP1, BCHE, BCL2L1, BAK1, JUN

GO Terms for genes affiliated with Renal Cell Carcinoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to renal cell carcinoma according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573745.4PIK3R5, PIK3C2A, PIK3CG, LRP1, RELA, SGCB
2nucleusGO:00563445.1ZNF354A, ZNF202, PIK3CB, PIK3R5, PIK3C2A, LRP1
3plasma membraneGO:00588640.4PIK3CD, PIK3R1, PIK3C2A, PIK3CG, KL, NCAM1
4cytosolGO:00582935.5PIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1
5extracellular spaceGO:00561530.2KL, KIT, KITLG, SFRP1, SFRP2, SELE
6integral to plasma membraneGO:00588723.8LRP1, KL, SGCB, CNR1, KIR2DL3, KIR3DL1
7nucleoplasmGO:00565421.6NCOA1, RELA, SFPQ, PCNA, RB1, RBM5
8cell surfaceGO:00998617.3NCAM1, KISS1R, SFRP1, BST2, VEGFA, VCAM1
9perinuclear region of cytoplasmGO:04847116.8SELE, LMNA, MYO6, LIMS1, CLU, PARK2
10external side of plasma membraneGO:00989716.1NCAM1, KIT, SELL, SELP, SERPINA5, VCAM1
11platelet alpha granule lumenGO:03109313.5SERPINE1, VEGFA, VEGFB, VEGFC, CLU, FN1
12extracellular regionGO:005576INFKL, NCAM1, KISS1, KITLG, SERPINA5, SEMA3B

Biological processes related to renal cell carcinoma according to GeneDecks:

(show top 50)    (show all 72)
idNameGO IDScoreTop Affiliating Genes
1signal transductionGO:00716525.9PIK3CB, PIK3CD, PDCD1, KIT, KITLG, BST2
2apoptotic processGO:00691522.9PDCD1, RBM5, NBN, VIM, LMNA, RASSF5
3positive regulation of cell proliferationGO:00828421.0KIT, SFRP1, SFRP2, NBN, VEGFA, VEGFC
4negative regulation of apoptotic processGO:04306620.5PIK3CG, RELA, SFRP1, BTG2, SERPINE1, BRAF
5response to drugGO:04249320.2SFRP1, SFRP2, NBN, VEGFC, MYC, PARK7
6positive regulation of transcription from RNA polymerase II promoterGO:04594419.9NCOA1, RELA, SFRP2, RB1, RBPJ, SERPINE1
7negative regulation of cell proliferationGO:00828519.5KISS1R, SFRP1, SFRP2, BTG2, RBM5, VHL
8positive regulation of transcription, DNA-dependentGO:04589319.4NCOA1, RELA, SFRP1, RB1, VHL, MYC
9blood coagulationGO:00759619.4PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3R5
10cell proliferationGO:00828318.0KITLG, PCNA, NBN, SERPINF1, BST2, RAF1
11inflammatory responseGO:00695418.0PIK3CD, PIK3CG, RELA, KIT, SELE, SELP
12cell adhesionGO:00715518.0NCAM1, KITLG, SELL, SELP, VCAM1, VCL
13cell-cell signalingGO:00726717.2SFRP2, SEMA3B, BST2, LHX1, CGB, CD70
14anti-apoptosisGO:00691617.0PIK3CA, RELA, SERPINB2, BRAF, VHL, VEGFB
15immune responseGO:00695517.0KIR2DL3, KIR3DL1, BMP6, CIITA, CHUK, CEBPB
16virus-host interactionGO:01904816.6PIK3R1, RELA, RB1, RBX1, VIM, VCAM1
17response to hypoxiaGO:00166616.6VEGFA, VCAM1, RAF1, PAK1, BCL2, SCNN1B
18positive regulation of apoptotic processGO:04306516.3NCOA1, CNR1, SFRP1, SFRP2, RBM5, RARB
19angiogenesisGO:00152516.0PIK3CA, PIK3CG, SETD2, SERPINE1, VEGFA, VEGFC
20induction of apoptosisGO:00691715.7BIK, PAWR, BCL2L11, LCK, BAD, BAX
21cytokine-mediated signaling pathwayGO:01922115.1NCAM1, RELA, KIT, VCAM1, CIITA, UBC
22cell migrationGO:01647714.6PIK3CB, PAK4, PAK7, CEACAM1, JUP, FSCN1
23activation of cysteine-type endopeptidase activity involved in apoptotic processGO:00691914.6MYC, BCL2L11, LCK, BAD, BAX, JAK2
24platelet degranulationGO:00257614.5SELP, SERPINE1, VEGFA, VEGFB, VEGFC, VCL
25cell cycle arrestGO:00705014.4RB1, NBN, MYC, RASSF1, KHDRBS1, SART1
26positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312313.9RELA, BST2, BIRC2, BIRC3, PARK2, LGALS1
27positive regulation of cell migrationGO:03033513.9VEGFA, KDR, JAK2, CDH13, ITGB1, MMP14
28epidermal growth factor receptor signaling pathwayGO:00717313.8PIK3CA, PIK3R1, PIK3C2A, RAF1, CHUK, YWHAB
29response to organic cyclic compoundGO:01407013.8SFRP1, BTG2, SELP, BAK1, MSH2, JUN
30positive regulation of angiogenesisGO:04576613.8SFRP2, SERPINE1, VEGFA, KDR, CHI3L1, MTDH
31insulin receptor signaling pathwayGO:00828613.7PIK3CB, PIK3CA, PIK3R3, PIK3R2, PIK3R1, PIK3C2A
32cellular response to stressGO:03355413.7RBX1, VHL, VEGFA, PAK1, UBC, ARNT
33fibroblast growth factor receptor signaling pathwayGO:00854313.7PIK3CA, PIK3R1, KL, BRAF, RAF1, CHUK
34nerve growth factor receptor signaling pathwayGO:04801113.6PIK3CB, PIK3CA, PIK3R2, PIK3R1, RELA, BRAF
35leukocyte migrationGO:05090013.5PIK3CB, PIK3CA, PIK3R2, PIK3R1, SELL, SELP
36induction of apoptosis by intracellular signalsGO:00862913.5MYC, CLU, BCL2, BCL2L1, BCL2L11, YWHAB
37phosphatidylinositol-mediated signalingGO:04801513.4PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2A, PCNA
38response to estradiol stimulusGO:03235513.4NCOA1, VDR, RARA, UCN, AURKA, MMP9
39T cell costimulationGO:03129513.4PIK3CA, PIK3R3, PIK3R2, PIK3R1, PDCD1, RAC1
40MAPK cascadeGO:00016513.4BRAP, MYC, RAF1, PAK1, PAK3, YWHAB
41positive regulation of protein kinase B signaling cascadeGO:05189713.4PIK3R5, PIK3CG, VEGFB, CHI3L1, MTDH, MTOR
42positive regulation of ERK1 and ERK2 cascadeGO:07037413.3BRAF, VEGFB, KDR, CHI3L1, MT3, CD74
43positive regulation of MAPK cascadeGO:04341013.2KIT, KDR, LEP, CDH2, ITGB1, FLT1
44agingGO:00756813.1KL, CNR1, SERPINF1, VDR, VCAM1, BAK1
45positive regulation of NF-kappaB transcription factor activityGO:05109212.9RELA, CLU, CHUK, UBC, MTDH, CD40
46positive regulation of MAP kinase activityGO:04340612.9PIK3R5, PIK3CG, KITLG, VEGFA, CD24, CD40
47positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406812.9KIT, SELP, KDR, UBE3A, JAK2, FLT1
48regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141812.5RBX1, VHL, VEGFA, UBC, ARNT, CA9
49positive regulation of protein phosphorylationGO:00193412.4VEGFA, MT3, MTOR, CD40, ITGB3, FLT4
50small molecule metabolic processGO:044281INFPIK3CB, PIK3CD, PIK3CA, PIK3R3, PIK3R2, PIK3R1

Molecular functions related to renal cell carcinoma according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551571.7PIK3CB, PIK3CD, PIK3CA, PIK3R2, PIK3R1, PIK3CG
2ATP bindingGO:00552420.2PIK3CB, PIK3CD, PIK3CA, PIK3C2A, PIK3CG, KIT
3protein homodimerization activityGO:04280319.0KIT, BST2, VEGFA, VEGFB, RAP1GAP, RABEP1
4identical protein bindingGO:04280218.0RELA, SFRP1, PCNA, GCC2, VIM, RAF1
5receptor bindingGO:00510217.1SERPINE1, RARA, LAMA4, S100A10, JAK2, CD276
6protein heterodimerization activityGO:04698216.5BRAF, VEGFA, VEGFB, MYC, BMP6, RARA
7growth factor activityGO:00808316.3KITLG, VEGFA, VEGFB, VEGFC, BMP6, BMP7
8cytokine activityGO:00512515.0KITLG, VEGFA, BMP6, BMP7, CD70, CD40LG
9enzyme bindingGO:01989914.4NCOA1, VHL, RARA, RAC1, BIRC5, BIRC7
10protein kinase bindingGO:01990113.3RELA, VIM, PAK1, PARK2, PAK2, BCL2L1

Sources for Renal Cell Carcinoma

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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