MCID: RNL014
MIFTS: 83

Renal Cell Carcinoma malady

Genetic diseases, Nephrological diseases, Cancer diseases, Rare diseases categories

Summaries for Renal Cell Carcinoma

About this section


OMIM:45 The Heidelberg histologic classification of renal cell tumors subdivides renal cell tumors into benign and malignant... (144700) more...

MalaCards based summary: Renal Cell Carcinoma, also known as renal carcinoma, chromophobe, somatic, is related to renal oncocytoma and kidney cancer, and has symptoms including sporadicand renal cell carcinoma. An important gene associated with Renal Cell Carcinoma is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase), and among its related pathways are Regulation of beta-cell development and Renal cell carcinoma. The drugs thalidomide and interferon alfa-2a and the compounds nnmt and glucose have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Disease Ontology:9 A renal carcinoma that has material basis in the lining of the proximal convoluted renal tubule of the kidney.

Novus Biologicals:44 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

Wikipedia:63 Renal cell carcinoma (RCC, also known as hypernephroma, Grawitz tumor, renal adenocarcinoma) is a kidney... more...

Aliases & Classifications for Renal Cell Carcinoma

About this section
Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 11DISEASES, 47Orphanet, 60UMLS, 10diseasecard, 22GTR, 33MeSH, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet
See all sources

Renal Cell Carcinoma, Aliases & Descriptions:

Name: Renal Cell Carcinoma 45 30 9 11 47 60
Renal Carcinoma, Chromophobe, Somatic 45 10
Nonpapillary Renal Cell Carcinoma 9 22
Rcc 9 47
Renal Cell Carcinoma, Clear Cell, Somatic 45
 
Conventional Renal Cell Carcinoma 60
Renal Cell Carcinoma, Nonpapillary 60
Renal Cell Carcinoma, Somatic 45
Adenocarcinoma of Kidney 9
Hypernephroma 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
renal cell carcinoma:
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Adult


External Ids:

OMIM45 144700
Disease Ontology9 DOID:0050387, DOID:4450
MeSH33 D002292
NCIt38 C9385
SNOMED-CT55 41607009, 254915003
Orphanet47 217071
ICD10 via Orphanet26 C64
UMLS via Orphanet61 C0007134
MESH via Orphanet34 D002292

Related Diseases for Renal Cell Carcinoma

About this section

Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 369)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma32.3FLCN, PRCC
2kidney cancer31.9FLCN, MET, VHL, CA9
3sarcoma31.8CA9, MET, TFE3
4cystic kidney31.5VHL, HNF1B
5von hippel-lindau syndrome31.5MET, VHL
6renal clear cell carcinoma31.5CA9, VHL, MET, MME
7alveolar soft-part sarcoma31.4TFE3, ASPSCR1, PRCC
8papillary adenoma31.4PRCC
9cystadenoma31.3MME, VHL
10adenocarcinoma31.3MME, MET, VHL, CA9, HNF1B, OGG1
11birt-hogg-dube syndrome31.3FLCN
12adenoma31.3MET, VHL, HNF1A, OGG1
13colorectal cancer31.0MET, CA9, HNF1A, OGG1
14cholangiocarcinoma30.9MME, MET, OGG1
15polycystic kidney disease30.8HNF1B, VHL
16breast cancer30.7MME, MET, VHL, CA9, HNF1A, OGG1
17hepatocellular carcinoma30.7MME, MET, HNF1B, HNF1A, OGG1
18clear cell renal cell carcinoma11.4
19chromophobe renal cell carcinoma11.2
20sarcomatoid renal cell carcinoma11.1
21endotheliitis11.0
22clear cell papillary renal cell carcinoma10.9
23hypoxia10.9
24multilocular cystic renal cell carcinoma10.9
25angiomyolipoma10.9
26melanoma10.9
27renal cell carcinoma, papillary10.8
28translocation renal cell carcinoma10.8
29kidney disease10.8
30familial renal cell carcinoma10.8
31hereditary renal cell carcinoma10.7
32thyroiditis10.7
33horseshoe kidney10.7
34leiomyomatosis10.7
35hemangioblastoma10.7
36tuberous sclerosis10.6
37pyelonephritis10.6
38oxyphilic adenoma10.6FLCN, MME, VHL, CA9
39xanthogranulomatous pyelonephritis10.6
40chromophil renal cell carcinoma10.6
41glomerulonephritis10.6
42thrombocytosis10.6
43collecting duct carcinoma10.6
44cerebral palsy10.6ASPSCR1
45lung cancer10.5OGG1, CA9, VHL, MET
46hypercalcemia10.5
47pancreatitis10.5
48hepatitis10.5
49leukemia10.5
50renal cell carcinoma 410.5

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Symptoms for Renal Cell Carcinoma

About this section


Clinical features from OMIM:

144700

HPO human phenotypes related to Renal Cell Carcinoma:

id Description Frequency HPO Source Accession
1 sporadic HP:0003745
2 renal cell carcinoma HP:0005584

Drugs & Therapeutics for Renal Cell Carcinoma

About this section

Genetic Tests for Renal Cell Carcinoma

About this section

Genetic tests related to Renal Cell Carcinoma:

id Genetic test Affiliating Genes
1 Renal Cell Carcinoma, Nonpapillary22

Anatomical Context for Renal Cell Carcinoma

About this section

MalaCards organs/tissues related to Renal Cell Carcinoma:

31
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Prostate, Brain, Lymph node, Liver, Myeloid, Skin, Monocytes, Breast, Testes, B cells, Testis, Neutrophil, Cortex, Pituitary, Smooth muscle, Bone marrow, Heart, Colon, Pancreas, Nk cells, Spinal cord, Small intestine, Adrenal gland, Tongue, Whole blood, Spleen, Skeletal muscle, Salivary gland, Ovary, Placenta

Animal Models for Renal Cell Carcinoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Renal Cell Carcinoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.5OGG1, MME, PBRM1, MET, VHL, HNF1B
2MP:000536710.5HNF1A, HNF1B, VHL, MET, FLCN
3MP:001076810.4TFE3, FLCN, PBRM1, MET, VHL, CA9
4MP:000538010.3FLCN, PBRM1, MET, VHL, HNF1B, NONO
5MP:000537610.1FLCN, MME, MET, VHL, HNF1B, HNF1A

Publications for Renal Cell Carcinoma

About this section

Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4337)
idTitleAuthorsYear
1
Urologic Pathology: CBS25-1 CLEAR CELL PAPILLARY RENAL CELL CARCINOMA. (25188173)
2014
2
Small tumour size is associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. (24060356)
2014
3
Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes. (23696916)
2013
4
Words of wisdom: re: multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. (23272732)
2013
5
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
6
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
7
Double jeopardy? Renal-sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma. (23914271)
2013
8
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. (23799843)
2013
9
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
10
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
11
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
12
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. (21632985)
2011
13
Progress in nephron sparing therapy for renal cell carcinoma and von Hippel-Lindau disease. (21496837)
2011
14
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. (20103651)
2010
15
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. (20121140)
2010
16
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
17
Increased activated Akt expression in renal cell carcinomas and prognosis. (18774962)
2009
18
Imprint cytologic features in renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in an adult: a case report. (20014561)
2009
19
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
20
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. (18709334)
2008
21
Renal cell carcinoma and antiangiogenic therapies]. (18035517)
2008
22
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
23
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. (17605814)
2007
24
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)
2006
25
Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features. (17121199)
2006
26
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
27
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. (15625368)
2005
28
Experimental study on induction of renal cell carcinoma apoptosis by antisense oligonucleotide targeting survivin. (15641694)
2004
29
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. (14654968)
2004
30
Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma. (14981959)
2003
31
Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma. (12963978)
2003
32
Interleukin-6, tumour necrosis factor alpha and interleukin-1beta in patients with renal cell carcinoma. (11986770)
2002
33
Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. (11369057)
2001
34
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. (11139287)
2000
35
Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma. (10537342)
1999
36
Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma. (9205056)
1997
37
Temporal arteritis presenting with concomitant renal cell carcinoma. (19078210)
1997
38
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (8660841)
1996
39
Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal cell carcinomas and effects on expression of interleukin-6 or interleukin-6 receptor. (7861551)
1995
40
Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. (8198979)
1994
41
Sarcomatoid renal cell carcinoma. A study of its proliferative activity. (8095849)
1993
42
Immunological study of interferon-gamma therapy for advanced renal cell carcinoma]. (1288223)
1992
43
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
44
Immune modulating effects of low doses of cyclophosphamide and keyhole limpet hemocyanin on peripheral blood immune parameters in patients with metastatic renal cell carcinoma. (1598724)
1992
45
Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma. (1795011)
1991
46
In vivo antiproliferative effects of gamma-interferon and tumor necrosis factor alpha in a rat renal cell carcinoma model system. (2111411)
1990
47
Comparative biochemical and immunological studies on gamma-glutamyltransferases from human kidney and renal cell carcinoma applying monoclonal antibodies. (1979761)
1990
48
Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma. A randomized trial. (2185803)
1990
49
Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. (2894030)
1988
50
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977

Variations for Renal Cell Carcinoma

About this section

UniProtKB/Swiss-Prot genetic disease variations for Renal Cell Carcinoma:

62
id Symbol AA change Variation ID SNP ID
1FLCNp.Arg239CysVAR_066026rs78683075
2VHLp.Leu163ProVAR_034998rs28940297

Cosmic variations for Renal Cell Carcinoma:

7 (show all 51)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1690METkidney,NS,carcinoma,papillary renal cell carcinoma3
2704METkidney,NS,carcinoma,papillary renal cell carcinoma3
3698METkidney,NS,carcinoma,papillary renal cell carcinoma3
4689METkidney,NS,carcinoma,papillary renal cell carcinoma3
5484661METkidney,NS,carcinoma,papillary renal cell carcinoma3
6697METkidney,NS,carcinoma,papillary renal cell carcinoma3
7696METkidney,NS,carcinoma,papillary renal cell carcinoma3
8688METkidney,NS,carcinoma,papillary renal cell carcinoma3
9691METkidney,NS,carcinoma,papillary renal cell carcinoma3
1010670TP53kidney,NS,carcinoma,chromophobe renal cell carcinoma3
1110659TP53kidney,NS,carcinoma,chromophobe renal cell carcinoma3
1210709TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
1345322TP53kidney,NS,carcinoma,chromophobe renal cell carcinoma3
1411450TP53kidney,NS,carcinoma,chromophobe renal cell carcinoma3
1543697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
1611071TP53kidney,NS,carcinoma,chromophobe renal cell carcinoma3
1743850TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
1817807VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1914311VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
2018346VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
2118028VHLkidney,NS,carcinoma,chromophobe renal cell carcinoma3
2230286VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
2317808VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
2425673VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
25760PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
26763PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
27718FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
283993568FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
29462BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
301131BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
3121945EGFRkidney,NS,carcinoma,papillary renal cell carcinoma3
3214060ERBB2kidney,NS,carcinoma,papillary renal cell carcinoma3
331583146DNMT3Akidney,NS,carcinoma,papillary renal cell carcinoma3
341181978ADARB1kidney,NS,carcinoma,papillary renal cell carcinoma3
35742462GFRALkidney,NS,carcinoma,papillary renal cell carcinoma3
36375283ANKHD1-EIF4EBP3kidney,NS,carcinoma,papillary renal cell carcinoma3
37274461CDC73kidney,NS,carcinoma,papillary renal cell carcinoma3
38302052DHX9kidney,NS,carcinoma,papillary renal cell carcinoma3
39375284ANKHD1kidney,NS,carcinoma,papillary renal cell carcinoma3
40964299MAP2K5kidney,NS,carcinoma,papillary renal cell carcinoma3
41485065RHEBkidney,NS,carcinoma,papillary renal cell carcinoma3
421222993RAD23Bkidney,NS,carcinoma,papillary renal cell carcinoma3
43487039SCAIkidney,NS,carcinoma,papillary renal cell carcinoma3
44110414SMARCB1kidney,NS,carcinoma,papillary renal cell carcinoma3
451268384TP63kidney,NS,carcinoma,papillary renal cell carcinoma3
461360764SOX5kidney,NS,carcinoma,papillary renal cell carcinoma3
475260PTENkidney,NS,carcinoma,papillary renal cell carcinoma3
48485575PMS2P11kidney,NS,carcinoma,papillary renal cell carcinoma3
49521KRASkidney,NS,carcinoma,papillary renal cell carcinoma3
50188258HIVEP3kidney,NS,carcinoma,papillary renal cell carcinoma3
51163384PDGFRAkidney,NS,carcinoma,papillary renal cell carcinoma3

Expression for genes affiliated with Renal Cell Carcinoma

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Renal Cell Carcinoma patients vs. healthy controls: 30 (show all 89)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ANGPTL4angiopoietin-like 4Kidney+7.250.000
2TNFAIP6tumor necrosis factor, alpha-induced protein 6Kidney+7.160.000
3APOC1apolipoprotein C-IKidney+6.110.000
4NPTX2neuronal pentraxin IIKidney+6.050.000
5PTHLHparathyroid hormone-like hormoneKidney+5.880.001
6NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2Kidney+5.760.000
7FABP7fatty acid binding protein 7, brainKidney+5.710.042
8CCL20chemokine (C-C motif) ligand 20Kidney+5.550.007
9CDCA2cell division cycle associated 2Kidney+5.520.000
10STC2stanniocalcin 2Kidney+5.390.000
11TOP2Atopoisomerase (DNA) II alpha 170kDaKidney+5.240.000
12EGLN3egl-9 family hypoxia-inducible factor 3Kidney+5.120.000
13NKG7natural killer cell granule protein 7Kidney+5.070.000
14NNMTnicotinamide N-methyltransferaseKidney+5.050.000
15FABP6fatty acid binding protein 6, ilealKidney+4.940.005
16CA9carbonic anhydrase IXKidney+4.920.000
17ISG20interferon stimulated exonuclease gene 20kDaKidney+4.890.000
18HK2hexokinase 2Kidney+4.710.000
19KISS1RKISS1 receptorKidney+4.670.001
20ARL11ADP-ribosylation factor-like 11Kidney+4.600.000
21C5orf46chromosome 5 open reading frame 46Kidney+4.590.016
22C3complement component 3Kidney+4.550.000
23CTHRC1collagen triple helix repeat containing 1Kidney+4.540.000
24CD300ACD300a moleculeKidney+4.490.001
25CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Kidney+4.450.012
26SLAMF7SLAM family member 7Kidney+4.450.001
27MIR155HGMIR155 host gene (non-protein coding)Kidney+4.440.001
28SLFN13schlafen family member 13Kidney+4.320.000
29SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Kidney+4.240.000
30FAM26Ffamily with sequence similarity 26, member FKidney+4.180.000
31SPAG4sperm associated antigen 4Kidney+4.130.000
32EHD2EH-domain containing 2Kidney+4.120.000
33CXCL9chemokine (C-X-C motif) ligand 9Kidney+4.110.001
34LOXlysyl oxidaseKidney+4.100.000
35CCNE2cyclin E2Kidney+4.080.000
36ENO2enolase 2 (gamma, neuronal)Kidney+4.080.000
37COL23A1collagen, type XXIII, alpha 1Kidney+4.030.003
38RGS1regulator of G-protein signaling 1Kidney+4.030.000
39CD86CD86 moleculeKidney+3.990.000
40CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 2Kidney+3.990.023
41HAPLN1hyaluronan and proteoglycan link protein 1Kidney+3.980.009
42TLR8toll-like receptor 8Kidney+3.980.000
43ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4Kidney+3.900.000
44AHNAK2AHNAK nucleoprotein 2Kidney+3.900.000
45RLTPRRGD motif, leucine rich repeats, tropomodulin domain and proline-rich containingBlood-3.890.000
46BIRC3baculoviral IAP repeat containing 3Kidney+3.880.000
47TTKTTK protein kinaseKidney+3.880.000
48HIST1H2AGhistone cluster 1, H2agKidney+3.870.007
49LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Kidney+3.870.000
50LOC100289026putative uncharacterized protein FLJ00310-likeKidney+3.860.006
51C4orf47chromosome 4 open reading frame 47Kidney+3.850.000
52CD248CD248 molecule, endosialinBlood-3.840.000
53INHBBinhibin, beta BKidney+3.840.001
54PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Kidney+3.840.003
55CPceruloplasmin (ferroxidase)Kidney+3.830.021
56BRIP1BRCA1 interacting protein C-terminal helicase 1Kidney+3.830.003
57HMHA1histocompatibility (minor) HA-1Kidney+3.830.000
58GAS2L3growth arrest-specific 2 like 3Kidney+3.830.000
59SPIBSpi-B transcription factor (Spi-1/PU.1 related)Blood-3.810.000
60TEX11testis expressed 11Kidney+3.790.029
61HILPDAhypoxia inducible lipid droplet-associatedKidney+3.790.000
62TREM2triggering receptor expressed on myeloid cells 2Kidney+3.790.000
63BHLHE41basic helix-loop-helix family, member e41Kidney+3.720.000
64TMCC1transmembrane and coiled-coil domain family 1Kidney+3.720.000
65KIF20Akinesin family member 20AKidney+3.720.000
66TPX2TPX2, microtubule-associatedKidney+3.700.000
67LRRN3leucine rich repeat neuronal 3Blood-3.610.000
68AEBP1AE binding protein 1Blood-3.530.000
69LGALSLlectin, galactoside-binding-likeBlood-3.430.000
70PLEKHB1pleckstrin homology domain containing, family B (evectins) member 1Blood-3.400.000
71CD22CD22 moleculeBlood-3.380.000
72EPHB6EPH receptor B6Blood-3.300.000
73MVDmevalonate (diphospho) decarboxylaseBlood-3.260.000
74FBLN2fibulin 2Blood-3.260.000
75FBXL16F-box and leucine-rich repeat protein 16Blood-3.230.000
76CR2complement component (3d/Epstein Barr virus) receptor 2Blood-3.210.000
77PRSS33protease, serine, 33Blood-3.210.000
78GNPNAT1glucosamine-phosphate N-acetyltransferase 1Blood-3.190.000
79RTKN2rhotekin 2Blood-3.190.000
80EPHA1EPH receptor A1Blood-3.160.000
81CRIP2cysteine-rich protein 2Blood-3.150.000
82SERINC5serine incorporator 5Blood-3.120.000
83HKDC1hexokinase domain containing 1Blood-3.110.000
84NT5E5'-nucleotidase, ecto (CD73)Blood-3.100.000
85PMEPA1prostate transmembrane protein, androgen induced 1Blood-3.090.000
86FCGBPFc fragment of IgG binding proteinBlood-3.070.000
87SALL2spalt-like transcription factor 2Blood-3.060.000
88GPA33glycoprotein A33 (transmembrane)Blood-3.020.000
89SLC27A5solute carrier family 27 (fatty acid transporter), member 5Blood-3.000.000

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Compounds for genes affiliated with Renal Cell Carcinoma

About this section
Sources:
43Novoseek, 24HMDB
See all sources

Compounds related to Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1nnmt4310.7HNF1A, HNF1B
2glucose4310.7HNF1A, HNF1B, CA9, VHL, MET, MME
3proline4310.7TFE3, MET, VHL, CA9, HNF1A
4pyrimidine43 2411.6HNF1A, OGG1, NONO
5rapamycin4310.6CA9, VHL, MET, FLCN
6oligonucleotide4310.6MET, VHL, HNF1B, HNF1A, OGG1
7adriamycin4310.5OGG1, MET, MME
8crcs4310.5MET, MME
9thymidine43 2411.5MME, MET, HNF1A, OGG1
10oxygen43 2411.3MME, MET, VHL, CA9, OGG1
11estrogen4310.1HNF1A, CA9, VHL, MET, MME

GO Terms for genes affiliated with Renal Cell Carcinoma

About this section

Cellular components related to Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:000563410.4KANK1, FLCN, FAM107A, ASPSCR1, PRCC, VHL
2nucleolusGO:000573010.1NONO, TFE3, PRCC, VHL, CA9, HNF1B

Biological processes related to Renal Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1regulation of pronephros sizeGO:003556510.7HNF1A, HNF1B
2positive regulation of transcription initiation from RNA polymerase II promoterGO:006026110.7HNF1A, HNF1B
3glucose homeostasisGO:004259310.6ASPSCR1, MET, HNF1A
4negative regulation of Rho protein signal transductionGO:003502410.6FLCN, KANK1
5positive regulation of transcription from RNA polymerase II promoterGO:004594410.6TFE3, FLCN, MET, HNF1B, HNF1A
6regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:006141810.5CA9, VHL
7branching morphogenesis of an epithelial tubeGO:004875410.5HNF1B, MET
8positive regulation of cell adhesionGO:004578510.5FLCN, TFE3
9insulin secretionGO:003007310.4HNF1B, HNF1A
10placenta developmentGO:000189010.2MET, PBRM1

Molecular functions related to Renal Cell Carcinoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:004421210.5HNF1A, HNF1B, TFE3
2protein bindingGO:000551510.1NONO, KANK1, FLCN, RNF139, MME, ASPSCR1

Products for genes affiliated with Renal Cell Carcinoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Renal Cell Carcinoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet