RCC
MCID: RNL014
MIFTS: 59

Renal Cell Carcinoma (RCC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Cell Carcinoma

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45Novus Biologicals, 32MalaCards
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Novus Biologicals:45 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards: Renal Cell Carcinoma, also known as renal cell carcinoma, stage unspecified, is related to renal clear cell carcinoma and renal oncocytoma. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways is Transcriptional misregulation in cancer. The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells.

Aliases & Classifications for Renal Cell Carcinoma

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60UMLS, 8Disease Ontology, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal cell carcinoma 8 60
renal cell carcinoma, stage unspecified 8
conventional renal cell carcinoma 60
adenocarcinoma of kidney 8
hypernephroma 8
rcc 8


External Ids:

Disease Ontology8 DOID:4450
MeSH34 D002292
SNOMED-CT56 41607009, 254915003
NCIt39 C9385

Related Diseases for Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Familial Renal Cell Carcinoma
Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma32.1VHL, CA9, MET, MME, KRT7
2renal oncocytoma31.4KRT7, CLDN8, PRCC
3melanoma31.2CA9, MET, MME
4von hippel-lindau disease31.2VHL, MET
5kidney cancer31.0PRCC, MET, TFE3, GAL3ST1, APEH, CA9
6adenoma31.0KRT7, MET, VHL
7hemangioblastoma30.9VHL
8sarcoma30.8CA9, TFE3, MET
9papillary adenoma30.7PRCC
10adenocarcinoma30.6KRT7, MME, MET, CA9, VHL
11metanephric adenoma30.6KRT7, KANK1
12renal cell carcinoma, papillary, 130.5PRCC, TFE3
13alveolar soft part sarcoma30.4TFE3, PRCC, ASPSCR1
14cystadenoma30.3VHL, MME, KRT7
15endometrial carcinoma30.2KRT7, MME, CA9
16lung cancer30.0KRT7, MET
17papillary renal cell carcinoma11.2
18papillary carcinoma11.2
19sarcomatoid renal cell carcinoma11.0
20hereditary renal cell carcinoma10.8
21angiomyolipoma10.8
22bone carcinoma10.8
23kidney disease10.7
24cystic kidney10.7
25thyroiditis10.7
26small cell carcinoma10.7
27renal adenoma10.6
28renal cell carcinoma, clear cell, somatic10.6
29parathyroid carcinoma10.6
30adrenal carcinoma10.6
31transitional cell carcinoma10.6
32tuberous sclerosis10.6
33nonpapillary renal cell carcinoma10.6
34leiomyomatosis10.6
35clear cell renal cell carcinoma10.6
36large cell carcinoma10.5
37bladder carcinoma10.5
38xanthogranulomatous pyelonephritis10.5
39collecting duct carcinoma10.5
40glomerulonephritis10.5
41in situ carcinoma10.5
42pyelonephritis10.5
43neuroendocrine carcinoma10.5
44multilocular clear cell renal cell carcinoma10.5
45thrombocytosis10.5
46hypercalcemia10.5
47chromophobe renal cell carcinoma10.5
48mucinous tubular and spindle renal cell carcinoma10.5
49eosinophilic variant of chromophobe renal cell carcinoma10.5
50adrenocortical carcinoma10.5

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Clinical Features for Renal Cell Carcinoma

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Drugs & Therapeutics for Renal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Renal Cell Carcinoma:

32
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Prostate, Liver, Lymph node, Skin, Breast, Colon, Testes, Monocytes, Brain, Myeloid, Pituitary, Smooth muscle, Pancreas, Tongue, Cortex, Heart, Ovary, B cells, Nk cells, Bone marrow, Small intestine, Spinal cord, Salivary gland, Adrenal gland, Testis, Skeletal muscle, Spleen, Placenta, Whole blood

Animal Models for Renal Cell Carcinoma or affiliated genes

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Publications for Renal Cell Carcinoma

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50PubMed
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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4568)
idTitleAuthorsYear
1
Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. (23982215)
2013
2
Detection of Merkel cell polyomavirus in oral samples of renal transplant recipients without Merkel cell carcinoma. (23852888)
2013
3
STAT3 polymorphism can predict the response to interferon-I+ therapy in patients with metastatic renal cell carcinoma. (23063454)
2013
4
Improved overall survival after implementation of targeted therapy for patients with metastatic renal cell carcinoma: Results from the Danish Renal Cancer Group (DARENCA) study-2. (24215846)
2013
5
Sex and the clinical value of body mass index in patients with clear cell renal cell carcinoma. (24002606)
2013
6
Xp11.2 translocation renal cell carcinoma associated with non-neoplastic osteoclast-like giant cells. (23782337)
2013
7
Thyroid-like metastases to the scalp from a papillary renal cell carcinoma: a case report. (22825524)
2012
8
Integrative genomic analyses of sporadic clear cell renal cell carcinoma define disease subtypes and potential new therapeutic targets. (22094876)
2012
9
Renal cell carcinoma arising from a horseshoe kidney in a chronic hemodialysis patient. (22740237)
2012
10
Chromophobe renal cell carcinoma: analysis of 53 cases. (22179197)
2012
11
Metastatic renal cell carcinoma with radiologic appearance of a meningioma. (22332182)
2012
12
CD146 gene expression in clear cell renal cell carcinoma: a potential marker for prediction of early recurrence after nephrectomy. (22826148)
2012
13
Application of simplified Fuhrman grading system in clear-cell renal cell carcinoma. (20804473)
2011
14
Macrophage infiltration and its prognostic relevance in clear cell renal cell carcinoma. (21453387)
2011
15
Male infertility associated with hereditary leiomyomatosis and renal cell carcinoma. (20056206)
2010
16
Editorial comment on: hybrid renal cell carcinomas containing histopathologic features of chromophobe renal cell carcinoma and oncocytoma have excellent oncologic outcomes. (19477584)
2010
17
Xp11 translocation renal cell carcinoma (RCC): extended immunohistochemical profile emphasizing novel RCC markers. (20679884)
2010
18
Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: bevacizumab in combination with interferon-alpha2a compared with sunitinib. (19920817)
2010
19
Apolipoprotein E/C1 locus variants modify renal cell carcinoma risk. (19808960)
2009
20
Thymidine kinase activity in serum of renal cell carcinoma patients is a useful prognostic marker. (19282758)
2009
21
Systemic therapy of metastatic renal cell carcinoma: from many options to the therapeutic strategy]. (19806342)
2009
22
The von Hippel-Lindau protein sensitizes renal carcinoma cells to apoptotic stimuli through stabilization of BIM(EL). (19305426)
2009
23
Sequential sorafenib and sunitinib for renal cell carcinoma. (19447417)
2009
24
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. (19549898)
2009
25
Carbonic anhydrase IX as a predictive biomarker for clear cell renal cell carcinoma. (18565906)
2008
26
Renal cell carcinoma with unusual metastasis to the gallbladder. (18392717)
2008
27
Renal cell carcinoma in children and young adults: analysis of clinicopathological, immunohistochemical and molecular characteristics with an emphasis on the spectrum of Xp11.2 translocation-associated and unusual clear cell subtypes. (18983462)
2008
28
5-Aza-2'-deoxycytidine suppresses human renal carcinoma cell growth in a xenograft model via up-regulation of the connexin 32 gene. (18264126)
2008
29
Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. (17908959)
2007
30
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. (16985214)
2007
31
Connexin 32 potentiates vinblastine-induced cytotoxicity in renal cell carcinoma cells. (17186540)
2007
32
Pathology case of the month. Young woman with abdominal pain and a right upper quadrant mass. Papillary renal cell carcinoma, type 2. (16774031)
2006
33
Stromal derived factor-1 (SDF-1/CXCL12) and CXCR4 in renal cell carcinoma metastasis. (17083723)
2006
34
Immunohistochemical analysis of mucinous tubular and spindle cell carcinoma and papillary renal cell carcinoma of the kidney: significant immunophenotypic overlap warrants diagnostic caution. (16330937)
2006
35
An interleukin-10 promoter polymorphism may influence tumor development in renal cell carcinoma. (15711248)
2005
36
Chromophobe renal cell carcinoma with microcystic and adenomatous arrangement and pigmentation--a diagnostic pitfall. Morphological, immunohistochemical, ultrastructural and molecular genetic report of 20 cases. (15756595)
2005
37
Re: Chromophobe renal cell carcinoma in a patient with the Birt-Hogg-Dube syndrome. (12771781)
2003
38
Expression of cyclooxygenase-2 in renal cell carcinoma: correlation with tumor cell proliferation, apoptosis, angiogenesis, expression of matrix metalloproteinase-2, and survival. (12738729)
2003
39
Sarcomatoid renal cell carcinoma with massive osteosarcomatous differentiation: an unusual image in clinical urology. (12736033)
2003
40
Chromophobe renal cell carcinoma with sarcomatoid transformation. (14571432)
2003
41
Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. (12209602)
2002
42
A phase II trial of intravenous gemcitabine and 5-fluorouracil with subcutaneous interleukin-2 and interferon-alpha in patients with metastatic renal cell carcinoma. (12173327)
2002
43
A novel t(1;8)(p13;p11) in a thymic carcinoma with unusual giant cell features and renal metastasis. (11172906)
2001
44
A case of concurrent uterine cervical adenocarcinoma and renal-cell carcinoma, and subsequent vaginal metastasis from the renal-cell carcinoma. (9564104)
1998
45
Low density lipoprotein receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels are coordinately reduced in human renal cell carcinoma. (8555255)
1996
46
Sarcomatoid renal cell carcinoma. An immunohistochemical and ultrastructural study. (8514474)
1993
47
Tumor markers in human renal cell carcinoma. (1871509)
1991
48
Human renal clear cell carcinoma: establishment and characterization of a new cell line (G-2101). (2453501)
1988
49
Abnormal cholesterol metabolism in renal clear cell carcinoma. (3681141)
1987
50
Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation. (2995998)
1985

Genetic Variations for Renal Cell Carcinoma

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Expression for genes affiliated with Renal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

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29KEGG
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Pathways related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2ASPSCR1, PRCC, MET, TFE3

Compounds for genes affiliated with Renal Cell Carcinoma

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44Novoseek
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Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen4411.7PTPRG, KRT7, MME, MET, CA9, VHL
2glucose4411.6VHL, CA9, TFE3, MET, MME, KRT7
3proline4411.2MET, TFE3, CA9, VHL
4paraffin4411.1CA9, MET, MME, KRT7
5vegf4411.1VHL, CA9, MET, MME, KRT7

GO Terms for genes affiliated with Renal Cell Carcinoma

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Products for genes affiliated with Renal Cell Carcinoma

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  • Antibodies
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Sources for Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet