RCC
MCID: RNL014
MIFTS: 51

Renal Cell Carcinoma (RCC) malady

Summaries for Renal Cell Carcinoma

Sources:
46Novus Biologicals, 33MalaCards
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Novus Biologicals:46 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards: Renal Cell Carcinoma, also known as renal cell carcinoma, stage unspecified, is related to renal clear cell carcinoma and adenoma. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways is Transcriptional misregulation in cancer. The drugs hydroxyurea and interferon alfa-2a and the compounds estrogen and glucose have been mentioned in the context of this disorder.

Aliases & Classifications for Renal Cell Carcinoma

Sources:
8Disease Ontology, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
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Aliases & Descriptions:

renal cell carcinoma 8 61
renal cell carcinoma, stage unspecified 8
conventional renal cell carcinoma 61
adenocarcinoma of kidney 8
hypernephroma 8
rcc 8


External Ids:

Disease Ontology8 DOID:4450
MeSH35 D002292
SNOMED-CT57 41607009, 254915003
NCIt40 C9385

Related Diseases for Renal Cell Carcinoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma32.1VHL, CA9, MET, MME, KRT7
2adenoma31.0KRT7, MET, VHL
3papillary adenoma30.8PRCC
4renal cell carcinoma, papillary, 130.7PRCC, TFE3
5adenocarcinoma30.7KRT7, MME, MET, CA9, VHL
6wilms tumor30.7KRT7, MME, VHL
7metanephric adenoma30.6KRT7, KANK1
8alveolar soft part sarcoma30.4TFE3, PRCC, ASPSCR1
9von hippel-lindau disease30.4VHL, MET
10cystadenoma30.3VHL, MME, KRT7
11teratoma30.2KRT7
12clear cell renal cell carcinoma11.4
13papillary renal cell carcinoma11.3
14papillary carcinoma11.2
15papillary renal carcinoma11.2
16chromophobe renal cell carcinoma11.2
17sarcomatoid renal cell carcinoma11.0
18hypoxia10.8
19multilocular cystic renal cell carcinoma10.8
20angiomyolipoma10.8
21bone carcinoma10.8
22familial renal cell carcinoma10.8
23renal cell carcinoma, clear cell, somatic10.7
24small cell carcinoma10.7
25horseshoe kidney10.7
26parathyroid carcinoma10.6
27adrenal carcinoma10.6
28tuberous sclerosis10.6
29nonpapillary renal cell carcinoma10.6
30large cell carcinoma10.6
31renal cell carcinoma, somatic10.6
32chromophil renal cell carcinoma10.6
33bladder carcinoma10.5
34xanthogranulomatous pyelonephritis10.5
35collecting duct carcinoma10.5
36neuroendocrine carcinoma10.5
37multilocular clear cell renal cell carcinoma10.5
38thrombocytosis10.5
39hypercalcemia10.5
40adrenocortical carcinoma10.5
41renal wilms' tumor10.5
42spindle cell carcinoma10.4
43n syndrome10.4
44transitional cell carcinoma10.4
45polycystic kidney disease10.4
46autosomal dominant disease10.4
47squamous cell carcinoma10.4
48polycystic kidney disease, autosomal dominant10.4
49tubulocystic carcinoma10.4
50hereditary leiomyomatosis and renal cell cancer10.4

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Clinical Features for Renal Cell Carcinoma

Drugs & Therapeutics for Renal Cell Carcinoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Genetic Tests for Renal Cell Carcinoma

Anatomical Context for Renal Cell Carcinoma

Animal Models for Renal Cell Carcinoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Renal Cell Carcinoma

Sources:
51PubMed
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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4571)
idTitleAuthorsYear
1
Local tumor destruction in renal cell carcinoma-An inpatient population-based study. (24360664)
2014
2
Prevention of Hepatitis B Virus Reactivation With Lamivudine in a Patient With Advanced Renal Cell Carcinoma Treated With Everolimus. (24368609)
2013
3
JAK3 in clear cell renal cell carcinoma: mutational screening and clinical implications. (21868263)
2013
4
Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. (23633458)
2013
5
Presurgical downstaging of vena caval tumor thrombus in advanced clear cell renal cell carcinoma using temsirolimus. (23186017)
2013
6
Prognostic significance of tumor thrombus consistency in patients with renal cell carcinoma. (24053185)
2013
7
Successful percutaneous radiologic management of renal cell carcinoma tumor seeding caused by percutaneous biopsy performed before ablation. (23973027)
2013
8
Reply to 'Distinct ALK-rearranged and VCL-negative papillary renal cell carcinoma variants in two adults without sickle cell trait'. (23542521)
2013
9
RALY RNA binding protein-like reduced expression is associated with poor prognosis in clear cell renal cell carcinoma. (22994768)
2012
10
Axitinib Induced Recurrent Pneumothorax following Near-Complete Response of Renal Cell Carcinoma Lung Metastasis: An Unexpected Complication. (23326741)
2012
11
Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. (22101383)
2012
12
Incidence and risk of congestive heart failure in patients with renal and nonrenal cell carcinoma treated with sunitinib. (21810682)
2011
13
Glucose-regulated protein 78 positivity as a predictor of poor survival in patients with renal cell carcinoma. (22076227)
2011
14
Copy number profiling in von Hippel-Lindau disease renal cell carcinoma. (21456047)
2011
15
Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma. (21717314)
2011
16
Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinib. (20602135)
2010
17
Vitamin d pathway genes, diet, and risk of renal cell carcinoma. (20049159)
2010
18
Re: Absolute preoperative C-reactive protein predicts metastasis and mortality in the first year following potentially curative nephrectomy for clear cell renal cell carcinoma: T. V. Johnson, A. Abbasi, A. Owen-Smith, A. Young, K. Ogan, J. Pattaras, P. Nieh, F. F. Marshall and V. A. Master J Urol 2010; 183: 480-485. (20728182)
2010
19
Loss of type III transforming growth factor-beta receptor expression is due to methylation silencing of the transcription factor GATA3 in renal cell carcinoma. (20208565)
2010
20
Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. (19150565)
2009
21
EGCG inhibits growth and induces apoptosis in renal cell carcinoma through TFPI-2 overexpression. (19212621)
2009
22
A case of tubulocystic carcinoma simultaneously occurring with clear cell type renal cell carcinoma and micropapillary urothelial carcinoma of bladder. (19488016)
2009
23
Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cells. (18787400)
2008
24
Carbonic anhydrase IX expression in clear cell renal cell carcinoma and normal tissues: experiences from (radio) immunotherapy. (18669472)
2008
25
Effect of retroperitoneal laparoscopic radical nephrectomy of renal carcinoma (nephroma) on perioperative cell immunity. (18811573)
2008
26
Phase II study of combination thalidomide/interleukin-2 therapy plus granulocyte macrophage-colony stimulating factor in patients with metastatic renal cell carcinoma. (18525301)
2008
27
Dynamic outcome prediction in patients with clear cell renal cell carcinoma treated with radical nephrectomy: the D-SSIGN score. (17222614)
2007
28
Synergistic in vivo antitumor effect of the histone deacetylase inhibitor MS-275 in combination with interleukin 2 in a murine model of renal cell carcinoma. (17671140)
2007
29
Targeting growth factor and antiangiogenic pathways in clear-cell renal cell carcinoma: rationale and ongoing trials. (17239282)
2006
30
Adjuvant subcutaneous interleukin-2 in patients with resected renal cell carcinoma: a pilot study. (16859579)
2006
31
Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors. (16820093)
2006
32
Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinoma. (15682460)
2005
33
Nevoid basal cell carcinoma syndrome associated with unilateral renal agenesis: acceleration of basal cell carcinomas following radiotherapy. (15987311)
2005
34
Renal cell carcinoma as a second malignant neoplasm in a patient with non-syndromic hemihypertrophy and previous Wilms tumor. (16010526)
2005
35
RAR-beta(1) overexpression in chromophobe renal cell carcinoma: a novel target for therapeutic intervention? (16244585)
2005
36
Clear cell papillary cystadenoma of the epididymis and mesosalpinx: immunohistochemical differentiation from metastatic clear cell renal cell carcinoma. (15767808)
2005
37
Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis. (15534102)
2004
38
Polymorphisms in the hypoxia inducible factor-1alpha gene (HIF1A) are associated with the renal cell carcinoma phenotype. (15350301)
2004
39
Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6--from the Groupe Francais d'Immunotherapie. (15197198)
2004
40
Melan A (A103) is expressed in adrenocortical neoplasms but not in renal cell and hepatocellular carcinomas. (14663359)
2003
41
Outpatient treatment with subcutaneous histamine dihydrochloride in combination with interleukin-2 and interferon-alpha in patients with metastatic renal cell carcinoma: results of an open single-armed multicentre phase II study. (11996477)
2002
42
FHIT expression in clear cell renal carcinomas: versatility of protein levels and correlation with survival. (11920739)
2002
43
Vascular endothelial growth factor expression, angiogenesis, and necrosis in renal cell carcinomas. (11764385)
2001
44
Establishment and characterization of renal cell carcinoma cell lines with multidrug resistance. (10850629)
2000
45
Rapidly progressive glomerulonephritis in a patient with advanced renal cell carcinoma. (9719175)
1998
46
Progelatinase A mRNA expression in cell lines derived from tumors in patients with metastatic renal cell carcinoma correlates inversely with survival. (9255309)
1997
47
Determination of in vitro drug sensitivity to a panel of cystostatic drugs and interferon alpha-2b in patients with renal cell carcinoma. (9405998)
1997
48
Immunological effect of recombinant interferon-gamma on tumor infiltrating lymphocytes of renal cell carcinoma--relationship with clinical stage]. (8686575)
1996
49
Stimulation of the expression and the enzyme activity of aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 on human renal cell carcinoma cells and renal tubular epithelial cells by T cell-derived cytokines, such as IL-4 and IL-13. (7743667)
1995
50
Papillary renal cell carcinoma: CT and sonographic evaluation. (6385668)
1984

Genetic Variations for Renal Cell Carcinoma

Expression for genes affiliated with Renal Cell Carcinoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

Sources:
30KEGG
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Pathways related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2ASPSCR1, PRCC, MET, TFE3

Compounds for genes affiliated with Renal Cell Carcinoma

Sources:
45Novoseek
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Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen4511.7MET, VHL, MME, KRT7, PTPRG, CA9
2glucose4511.6KRT7, VHL, MET, TFE3, MME, CA9
3proline4511.2MET, TFE3, CA9, VHL
4paraffin4511.1KRT7, MME, MET, CA9
5vegf4511.1KRT7, VHL, CA9, MET, MME

GO Terms for genes affiliated with Renal Cell Carcinoma

Products for genes affiliated with Renal Cell Carcinoma

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Sources for Renal Cell Carcinoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet