RCC
MCID: RNL014
MIFTS: 63

Renal Cell Carcinoma (RCC) malady

Genetic diseases, Cancer diseases, Nephrological diseases, Rare diseases categories

Summaries for Renal Cell Carcinoma

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Novus Biologicals:45 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards based summary: Renal Cell Carcinoma, also known as adenocarcinoma of kidney, is related to renal oncocytoma and von hippel-lindau disease. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways are Regulation of Hypoxia-inducible Factor (HIF) by Oxygen and Renal cell carcinoma. The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds crcs and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells.

Disease Ontology:9 A renal carcinoma that has material basis in the lining of the proximal convoluted renal tubule of the kidney.

Aliases & Classifications for Renal Cell Carcinoma

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Renal Cell Carcinoma, Aliases & Descriptions:

Name: Renal Cell Carcinoma 31 9 61
Adenocarcinoma of Kidney 9 61
Conventional Renal Cell Carcinoma 61
 
Hypernephroma 9
Rcc 9


Classifications:



External Ids:

Disease Ontology9 DOID:4450
MeSH34 D002292
SNOMED-CT56 41607009, 254915003
NCIt39 C9385

Related Diseases for Renal Cell Carcinoma

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Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma31.9PRCC, FLCN, CLDN8
2von hippel-lindau disease31.7VHL, MET
3kidney cancer31.5VHL, FLCN
4sarcoma31.3TFE3, MET, CA9
5alveolar soft part sarcoma31.1TFE3, ASPSCR1, PRCC
6renal clear cell carcinoma31.0MME, MET, VHL, CA9
7cystadenoma30.9VHL, MME
8clear cell renal cell carcinoma11.4
9papillary renal cell carcinoma11.3
10chromophobe renal cell carcinoma11.2
11sarcomatoid renal cell carcinoma11.0
12endotheliitis11.0
13multilocular cystic renal cell carcinoma10.9
14hypoxia10.9
15clear cell papillary renal cell carcinoma10.9
16melanoma10.9
17angiomyolipoma10.8
18kidney disease10.8
19familial renal cell carcinoma10.8
20thyroiditis10.7
21hereditary renal cell carcinoma10.7
22horseshoe kidney10.7
23adenoma10.7
24renal cell carcinoma, clear cell, somatic10.7
25hemangioblastoma10.7
26leiomyomatosis10.7
27cystic kidney10.7
28tuberous sclerosis10.6
29pyelonephritis10.6
30nonpapillary renal cell carcinoma10.6
31xanthogranulomatous pyelonephritis10.6
32chromophil renal cell carcinoma10.6
33glomerulonephritis10.6
34collecting duct carcinoma10.6
35thrombocytosis10.5
36hypercalcemia10.5
37pancreatitis10.5
38hepatitis10.5
39leukemia10.5
40paraneoplastic syndromes10.5
41wilms tumor10.5
42adenocarcinoma10.5
43prostatitis10.5
44renal cell carcinoma 410.5
45metanephric adenoma10.5
46polycystic kidney disease10.5
47adrenocortical carcinoma10.5
48mucinous tubular and spindle cell carcinoma10.5
49spindle cell carcinoma10.4
50transitional cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Symptoms for Renal Cell Carcinoma

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Drugs & Therapeutics for Renal Cell Carcinoma

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Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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MalaCards organs/tissues related to Renal Cell Carcinoma:

32
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Lymph node, Liver, Skin, Prostate, Monocytes, Breast, Testes, Brain, Neutrophil, Cortex, Colon, Myeloid, Smooth muscle, Bone marrow, Heart, Pancreas, Nk cells, Spinal cord, Small intestine, Adrenal gland, B cells, Tongue, Pituitary, Whole blood, Spleen, Skeletal muscle, Salivary gland, Ovary, Placenta, Testis

Animal Models for Renal Cell Carcinoma or affiliated genes

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Publications for Renal Cell Carcinoma

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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4259)
idTitleAuthorsYear
1
Urologic Pathology: CBS25-1 CLEAR CELL PAPILLARY RENAL CELL CARCINOMA. (25188173)
2014
2
Small tumour size is associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. (24060356)
2014
3
The molecular biology of renal cell carcinoma. (23972705)
2013
4
Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes. (23696916)
2013
5
Words of wisdom: re: multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. (23272732)
2013
6
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
7
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
8
Double jeopardy? Renal-sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma. (23914271)
2013
9
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. (23799843)
2013
10
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
11
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
12
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
13
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. (21632985)
2011
14
Progress in nephron sparing therapy for renal cell carcinoma and von Hippel-Lindau disease. (21496837)
2011
15
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. (20103651)
2010
16
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. (20121140)
2010
17
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
18
Increased activated Akt expression in renal cell carcinomas and prognosis. (18774962)
2009
19
Imprint cytologic features in renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in an adult: a case report. (20014561)
2009
20
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
21
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. (18709334)
2008
22
Renal cell carcinoma and antiangiogenic therapies]. (18035517)
2008
23
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
24
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. (17605814)
2007
25
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)
2006
26
Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features. (17121199)
2006
27
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
28
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. (15625368)
2005
29
Experimental study on induction of renal cell carcinoma apoptosis by antisense oligonucleotide targeting survivin. (15641694)
2004
30
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. (14654968)
2004
31
Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma. (14981959)
2003
32
Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma. (12963978)
2003
33
Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. (11369057)
2001
34
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. (11139287)
2000
35
Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma. (10537342)
1999
36
Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma. (9205056)
1997
37
Temporal arteritis presenting with concomitant renal cell carcinoma. (19078210)
1997
38
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (8660841)
1996
39
Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal cell carcinomas and effects on expression of interleukin-6 or interleukin-6 receptor. (7861551)
1995
40
Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. (8198979)
1994
41
Sarcomatoid renal cell carcinoma. A study of its proliferative activity. (8095849)
1993
42
Immunological study of interferon-gamma therapy for advanced renal cell carcinoma]. (1288223)
1992
43
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
44
Immune modulating effects of low doses of cyclophosphamide and keyhole limpet hemocyanin on peripheral blood immune parameters in patients with metastatic renal cell carcinoma. (1598724)
1992
45
Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma. (1795011)
1991
46
In vivo antiproliferative effects of gamma-interferon and tumor necrosis factor alpha in a rat renal cell carcinoma model system. (2111411)
1990
47
Comparative biochemical and immunological studies on gamma-glutamyltransferases from human kidney and renal cell carcinoma applying monoclonal antibodies. (1979761)
1990
48
Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma. A randomized trial. (2185803)
1990
49
Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. (2894030)
1988
50
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977

Variations for Renal Cell Carcinoma

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Expression for genes affiliated with Renal Cell Carcinoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets, 31LifeMap Discovery®
See all sources
LifeMap Discovery
Genes differentially expressed in tissues of Renal Cell Carcinoma patients vs. healthy controls: 31 (show all 320)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SLC12A1solute carrier family 12 (sodium/potassium/chloride transporter), member 1Kidney-9.350.000
2CALB1calbindin 1, 28kDaKidney-8.950.000
3FXYD4FXYD domain containing ion transport regulator 4Kidney-8.290.000
4CLDN8claudin 8Kidney-8.200.000
5KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1Kidney-8.200.000
6NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin)Kidney-8.180.000
7MUC15mucin 15, cell surface associatedKidney-7.960.000
8SCNN1Gsodium channel, non-voltage-gated 1, gamma subunitKidney-7.910.000
9HPD4-hydroxyphenylpyruvate dioxygenaseKidney-7.780.000
10FABP1fatty acid binding protein 1, liverKidney-7.740.000
11DNASE1deoxyribonuclease IKidney-7.590.000
12SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13Kidney-7.290.000
13ANGPTL4angiopoietin-like 4Kidney+7.250.000
14TNFAIP6tumor necrosis factor, alpha-induced protein 6Kidney+7.160.000
15ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Kidney-7.130.000
16PCP4Purkinje cell protein 4Kidney-7.130.000
17KNG1kininogen 1Kidney-7.120.000
18TYRP1tyrosinase-related protein 1Kidney-7.100.000
19FGF9fibroblast growth factor 9Kidney-6.990.000
20EGFepidermal growth factorKidney-6.920.000
21RALYLRALY RNA binding protein-likeKidney-6.810.000
22PVALBparvalbuminKidney-6.730.000
23KCNJ10potassium inwardly-rectifying channel, subfamily J, member 10Kidney-6.690.000
24TMEM213transmembrane protein 213Kidney-6.640.000
25SLC22A8solute carrier family 22 (organic anion transporter), member 8Kidney-6.580.000
26IRX2iroquois homeobox 2Kidney-6.560.000
27SLC26A7solute carrier family 26 (anion exchanger), member 7Kidney-6.560.000
28SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Kidney-6.530.000
29GPC5glypican 5Kidney-6.530.000
30RHCGRh family, C glycoproteinKidney-6.520.000
31SOSTsclerostinKidney-6.510.000
32SFRP1secreted frizzled-related protein 1Kidney-6.490.000
33HEPACAM2HEPACAM family member 2Kidney-6.450.000
34NELL1NEL-like 1 (chicken)Kidney-6.380.000
35SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Kidney-6.340.000
36RAB25RAB25, member RAS oncogene familyKidney-6.320.000
37TMPRSS2transmembrane protease, serine 2Kidney-6.310.000
38TMEM52Btransmembrane protein 52BKidney-6.280.000
39ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4Kidney-6.260.000
40SOSTDC1sclerostin domain containing 1Kidney-6.250.000
41SH3GL2SH3-domain GRB2-like 2Kidney-6.160.000
42ALDOBaldolase B, fructose-bisphosphateKidney-6.130.003
43APOC1apolipoprotein C-IKidney+6.110.000
44UMODuromodulinKidney-6.070.000
45NPTX2neuronal pentraxin IIKidney+6.050.000
46LOC284578uncharacterized LOC284578Kidney-6.020.000
47ESRRBestrogen-related receptor betaKidney-5.990.000
48SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Kidney-5.960.001
49TSPAN8tetraspanin 8Kidney-5.960.000
50WNK4WNK lysine deficient protein kinase 4Kidney-5.940.000
51DIO1deiodinase, iodothyronine, type IKidney-5.930.000
52PTHLHparathyroid hormone-like hormoneKidney+5.880.001
53NDUFA4L2NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2Kidney+5.760.000
54ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3Kidney-5.730.000
55NOS1nitric oxide synthase 1 (neuronal)Kidney-5.730.000
56FABP7fatty acid binding protein 7, brainKidney+5.710.042
57SIM2single-minded family bHLH transcription factor 2Kidney-5.660.000
58XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundKidney-5.650.000
59G6PCglucose-6-phosphatase, catalytic subunitKidney-5.640.013
60SCNN1Asodium channel, non-voltage-gated 1 alpha subunitKidney-5.630.002
61ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1Kidney-5.620.000
62HSD11B2hydroxysteroid (11-beta) dehydrogenase 2Kidney-5.600.000
63CCL20chemokine (C-C motif) ligand 20Kidney+5.550.007
64HS6ST2heparan sulfate 6-O-sulfotransferase 2Kidney-5.520.000
65CDCA2cell division cycle associated 2Kidney+5.520.000
66DPEP1dipeptidase 1 (renal)Kidney-5.490.000
67SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9Kidney-5.490.000
68C16orf89chromosome 16 open reading frame 89Kidney-5.480.000
69CTXN3cortexin 3Kidney-5.470.001
70LOC285556uncharacterized LOC285556Kidney-5.470.000
71FAM3Bfamily with sequence similarity 3, member BKidney-5.430.000
72HRGhistidine-rich glycoproteinKidney-5.400.000
73PLGplasminogenKidney-5.400.000
74STC2stanniocalcin 2Kidney+5.390.000
75ENPP6ectonucleotide pyrophosphatase/phosphodiesterase 6Kidney-5.380.000
76MST1Lmacrophage stimulating 1-likeKidney-5.340.000
77PAHphenylalanine hydroxylaseKidney-5.320.003
78MFSD4major facilitator superfamily domain containing 4Kidney-5.310.000
79SCNN1Bsodium channel, non-voltage-gated 1, beta subunitKidney-5.290.000
80PRDM16PR domain containing 16Kidney-5.290.000
81FAM151Afamily with sequence similarity 151, member AKidney-5.290.004
82MALmal, T-cell differentiation proteinKidney-5.290.001
83CA10carbonic anhydrase XKidney-5.290.000
84GRM1glutamate receptor, metabotropic 1Kidney-5.280.000
85RANBP3LRAN binding protein 3-likeKidney-5.270.000
86CLCNKBchloride channel, voltage-sensitive KbKidney-5.260.000
87NRKNik related kinaseKidney-5.260.000
88VTCN1V-set domain containing T cell activation inhibitor 1Kidney-5.260.000
89ESRP1epithelial splicing regulatory protein 1Kidney-5.250.001
90TOP2Atopoisomerase (DNA) II alpha 170kDaKidney+5.240.000
91CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Kidney-5.210.000
92ZNF44zinc finger protein 44Kidney-5.190.000
93DUSP9dual specificity phosphatase 9Kidney-5.150.000
94AQP2aquaporin 2 (collecting duct)Kidney-5.150.000
95SLC22A7solute carrier family 22 (organic anion transporter), member 7Kidney-5.130.008
96VGLL1vestigial-like family member 1Kidney-5.120.000
97EGLN3egl-9 family hypoxia-inducible factor 3Kidney+5.120.000
98DMRT2doublesex and mab-3 related transcription factor 2Kidney-5.110.000
99TACSTD2tumor-associated calcium signal transducer 2Kidney-5.110.000
100CASRcalcium-sensing receptorKidney-5.110.000
101SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2Kidney-5.110.000
102UPP2uridine phosphorylase 2Kidney-5.100.000
103LPPR1lipid phosphate phosphatase-related protein type 1Kidney-5.080.000
104CRYAAcrystallin, alpha AKidney-5.080.000
105NKG7natural killer cell granule protein 7Kidney+5.070.000
106C7complement component 7Kidney-5.070.002
107RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Kidney-5.050.000
108NNMTnicotinamide N-methyltransferaseKidney+5.050.000
109MYO3Bmyosin IIIBKidney-5.050.001
110CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)Kidney-5.030.002
111ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideKidney-5.020.001
112TMEM61transmembrane protein 61Kidney-4.990.000
113SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12Kidney-4.970.001
114ELF5E74-like factor 5 (ets domain transcription factor)Kidney-4.960.000
115TOX3TOX high mobility group box family member 3Kidney-4.940.019
116FLJ22763uncharacterized LOC401081Kidney-4.940.006
117FABP6fatty acid binding protein 6, ilealKidney+4.940.005
118TCEAL2transcription elongation factor A (SII)-like 2Kidney-4.920.003
119CA9carbonic anhydrase IXKidney+4.920.000
120LOC149703uncharacterized LOC149703Kidney-4.920.001
121TMEM45Btransmembrane protein 45BKidney-4.920.003
122EHFets homologous factorKidney-4.900.000
123ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2Kidney-4.900.000
124ISG20interferon stimulated exonuclease gene 20kDaKidney+4.890.000
125BMPR1Bbone morphogenetic protein receptor, type IBKidney-4.880.001
126SLC22A6solute carrier family 22 (organic anion transporter), member 6Kidney-4.870.011
127SCN2Asodium channel, voltage-gated, type II, alpha subunitKidney-4.870.001
128SLC7A8solute carrier family 7 (amino acid transporter light chain, L system), member 8Kidney-4.860.000
129KLRG2killer cell lectin-like receptor subfamily G, member 2Kidney-4.840.000
130GGT6gamma-glutamyltransferase 6Kidney-4.830.000
131ACPPacid phosphatase, prostateKidney-4.830.000
132PROM2prominin 2Kidney-4.770.000
133PLCXD3phosphatidylinositol-specific phospholipase C, X domain containing 3Kidney-4.770.000
134CLDN16claudin 16Kidney-4.770.000
135AFMafaminKidney-4.760.001
136KCNE1potassium voltage-gated channel, Isk-related family, member 1Kidney-4.760.000
137CLIC5chloride intracellular channel 5Kidney-4.730.000
138GPR110G protein-coupled receptor 110Kidney-4.720.000
139GATA3GATA binding protein 3Kidney-4.720.002
140ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney-4.710.000
141HK2hexokinase 2Kidney+4.710.000
142TFCP2L1transcription factor CP2-like 1Kidney-4.710.000
143GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2Kidney-4.700.000
144CLDN19claudin 19Kidney-4.680.000
145PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AKidney-4.670.021
146KISS1RKISS1 receptorKidney+4.670.001
147ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideKidney-4.650.000
148TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Kidney-4.630.000
149PTGER1prostaglandin E receptor 1 (subtype EP1), 42kDaKidney-4.620.000
150STAP1signal transducing adaptor family member 1Kidney-4.610.000
151ARL11ADP-ribosylation factor-like 11Kidney+4.600.000
152LINC00982long intergenic non-protein coding RNA 982Kidney-4.600.000
153CHL1cell adhesion molecule L1-likeKidney-4.600.001
154FOXI1forkhead box I1Kidney-4.590.000
155C5orf46chromosome 5 open reading frame 46Kidney+4.590.016
156ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)Kidney-4.580.001
157ALBalbuminKidney-4.570.000
158L1CAML1 cell adhesion moleculeKidney-4.570.004
159PDGFRAplatelet-derived growth factor receptor, alpha polypeptideKidney-4.560.009
160FGF1fibroblast growth factor 1 (acidic)Kidney-4.560.000
161C3complement component 3Kidney+4.550.000
162TMEM207transmembrane protein 207Kidney-4.550.000
163CTHRC1collagen triple helix repeat containing 1Kidney+4.540.000
164KLHL14kelch-like family member 14Kidney-4.530.001
165ANGPTL1angiopoietin-like 1Kidney-4.530.002
166SLC12A3solute carrier family 12 (sodium/chloride transporter), member 3Kidney-4.500.000
167CD300ACD300a moleculeKidney+4.490.001
168TMEM178Atransmembrane protein 178AKidney-4.480.000
169SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DKidney-4.470.000
170CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)Kidney+4.450.012
171TCF21transcription factor 21Kidney-4.450.002
172SLAMF7SLAM family member 7Kidney+4.450.001
173PDE1Aphosphodiesterase 1A, calmodulin-dependentKidney-4.440.000
174MIR155HGMIR155 host gene (non-protein coding)Kidney+4.440.001
175SOWAHAsosondowah ankyrin repeat domain family member AKidney-4.440.007
176HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)Kidney-4.430.036
177RBP4retinol binding protein 4, plasmaKidney-4.430.009
178SLFN13schlafen family member 13Kidney+4.320.000
179SLC16A3solute carrier family 16 (monocarboxylate transporter), member 3Kidney+4.240.000
180FAM26Ffamily with sequence similarity 26, member FKidney+4.180.000
181SPAG4sperm associated antigen 4Kidney+4.130.000
182EHD2EH-domain containing 2Kidney+4.120.000
183CXCL9chemokine (C-X-C motif) ligand 9Kidney+4.110.001
184LOXlysyl oxidaseKidney+4.100.000
185CCNE2cyclin E2Kidney+4.080.000
186ENO2enolase 2 (gamma, neuronal)Kidney+4.080.000
187COL23A1collagen, type XXIII, alpha 1Kidney+4.030.003
188RGS1regulator of G-protein signaling 1Kidney+4.030.000
189CD86CD86 moleculeKidney+3.990.000
190CYP2J2cytochrome P450, family 2, subfamily J, polypeptide 2Kidney+3.990.023
191HAPLN1hyaluronan and proteoglycan link protein 1Kidney+3.980.009
192TLR8toll-like receptor 8Kidney+3.980.000
193ST8SIA4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4Kidney+3.900.000
194AHNAK2AHNAK nucleoprotein 2Kidney+3.900.000
195BIRC3baculoviral IAP repeat containing 3Kidney+3.880.000
196TTKTTK protein kinaseKidney+3.880.000
197HIST1H2AGhistone cluster 1, H2agKidney+3.870.007
198LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2Kidney+3.870.000
199LOC100289026putative uncharacterized protein FLJ00310-likeKidney+3.860.006
200C4orf47chromosome 4 open reading frame 47Kidney+3.850.000
201INHBBinhibin, beta BKidney+3.840.001
202PLA2G7phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)Kidney+3.840.003
203CPceruloplasmin (ferroxidase)Kidney+3.830.021
204BRIP1BRCA1 interacting protein C-terminal helicase 1Kidney+3.830.003
205HMHA1histocompatibility (minor) HA-1Kidney+3.830.000
206GAS2L3growth arrest-specific 2 like 3Kidney+3.830.000
207TEX11testis expressed 11Kidney+3.790.029
208HILPDAhypoxia inducible lipid droplet-associatedKidney+3.790.000
209TREM2triggering receptor expressed on myeloid cells 2Kidney+3.790.000
210BHLHE41basic helix-loop-helix family, member e41Kidney+3.720.000
211TMCC1transmembrane and coiled-coil domain family 1Kidney+3.720.000
212KIF20Akinesin family member 20AKidney+3.720.000
213TPX2TPX2, microtubule-associatedKidney+3.700.000
214SEC16BSEC16 homolog B (S. cerevisiae)Kidney+3.700.000
215PVT1Pvt1 oncogene (non-protein coding)Kidney+3.690.000
216TRDV3T cell receptor delta variable 3Kidney+3.640.000
217HTRA4HtrA serine peptidase 4Kidney+3.630.005
218TMEM45Atransmembrane protein 45AKidney+3.630.016
219SLC6A3solute carrier family 6 (neurotransmitter transporter), member 3Kidney+3.620.012
220CDKN2Acyclin-dependent kinase inhibitor 2AKidney+3.590.000
221RHOHras homolog family member HKidney+3.590.000
222PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Kidney+3.590.003
223NETO2neuropilin (NRP) and tolloid (TLL)-like 2Kidney+3.570.001
224NEK2NIMA-related kinase 2Kidney+3.570.000
225P2RX7purinergic receptor P2X, ligand-gated ion channel, 7Kidney+3.570.000
226SIRPGsignal-regulatory protein gammaKidney+3.540.015
227ALOX5arachidonate 5-lipoxygenaseKidney+3.530.000
228TRDT cell receptor delta locusKidney+3.520.000
229TEN1TEN1 CST complex subunitKidney+3.500.000
230SLAMF8SLAM family member 8Kidney+3.500.001
231CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Kidney+3.490.000
232BIN2bridging integrator 2Kidney+3.460.000
233TNFRSF4tumor necrosis factor receptor superfamily, member 4Kidney+3.440.001
234FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)Kidney+3.420.000
235BRCA2breast cancer 2, early onsetKidney+3.390.000
236SLC17A4solute carrier family 17, member 4Kidney+3.380.019
237CXCL10chemokine (C-X-C motif) ligand 10Kidney+3.380.007
238PIK3R5phosphoinositide-3-kinase, regulatory subunit 5Kidney+3.370.000
239IGFBP3insulin-like growth factor binding protein 3Kidney+3.360.000
240VSIG1V-set and immunoglobulin domain containing 1Kidney+3.350.013
241ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Kidney+3.330.004
242HIST1H3Hhistone cluster 1, H3hKidney+3.320.012
243GIT2G protein-coupled receptor kinase interacting ArfGAP 2Kidney+3.300.000
244CDKN3cyclin-dependent kinase inhibitor 3Kidney+3.290.000
245FANCIFanconi anemia, complementation group IKidney+3.270.000
246CDC25Ccell division cycle 25CKidney+3.260.010
247DUSP4dual specificity phosphatase 4Kidney+3.260.003
248CCL5chemokine (C-C motif) ligand 5Kidney+3.240.003
249DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Kidney+3.230.000
250CXCL11chemokine (C-X-C motif) ligand 11Kidney+3.210.010
251CST7cystatin F (leukocystatin)Kidney+3.200.004
252TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bKidney+3.190.000
253RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Kidney+3.190.002
254PARVGparvin, gammaKidney+3.180.000
255BUB1BUB1 mitotic checkpoint serine/threonine kinaseKidney+3.180.012
256ZNF395zinc finger protein 395Kidney+3.170.021
257MCM10minichromosome maintenance complex component 10Kidney+3.170.007
258TMEM44transmembrane protein 44Kidney+3.150.000
259LOXL2lysyl oxidase-like 2Kidney+3.140.003
260CD8ACD8a moleculeKidney+3.140.011
261XCL1chemokine (C motif) ligand 1Kidney+3.120.002
262VNN2vanin 2Kidney+3.110.005
263CENPKcentromere protein KKidney+3.110.001
264RRM2ribonucleotide reductase M2Kidney+3.090.006
265CHPF2chondroitin polymerizing factor 2Kidney+3.090.000
266CRTAMcytotoxic and regulatory T cell moleculeKidney+3.080.012
267SCDstearoyl-CoA desaturase (delta-9-desaturase)Kidney+3.080.001
268IL7Rinterleukin 7 receptorKidney+3.070.018
269LPCAT1lysophosphatidylcholine acyltransferase 1Kidney+3.050.000
270LCKlymphocyte-specific protein tyrosine kinaseKidney+3.050.000
271SAP30Sin3A-associated protein, 30kDaKidney+3.050.000
272PCSK6proprotein convertase subtilisin/kexin type 6Kidney+3.050.025
273TEAD4TEA domain family member 4Kidney+3.050.000
274SCARB1scavenger receptor class B, member 1Kidney+3.040.001
275CLEC12AC-type lectin domain family 12, member AKidney+3.030.003
276MYO9Bmyosin IXBKidney+3.010.001
277LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1Kidney+3.010.002
278PRR11proline rich 11Kidney+3.000.001
279CTSScathepsin SKidney+3.000.000
280IKBIPIKBKB interacting proteinKidney+3.000.001
281CARScysteinyl-tRNA synthetaseKidney+2.990.009
282BCAP29B-cell receptor-associated protein 29Kidney+2.990.000
283BTN3A2butyrophilin, subfamily 3, member A2Kidney+2.990.001
284EGFRepidermal growth factor receptorKidney+2.990.017
285STK10serine/threonine kinase 10Kidney+2.990.000
286CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)Kidney+2.990.000
287PCDH17protocadherin 17Kidney+2.990.002
288ANLNanillin, actin binding proteinKidney+2.980.007
289EFCAB3EF-hand calcium binding domain 3Kidney+2.980.031
290ENPP3ectonucleotide pyrophosphatase/phosphodiesterase 3Kidney+2.970.047
291VWFvon Willebrand factorKidney+2.960.005
292SIGLEC10sialic acid binding Ig-like lectin 10Kidney+2.950.003
293ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)Kidney+2.950.000
294ADAM28ADAM metallopeptidase domain 28Kidney+2.930.001
295CXCR4chemokine (C-X-C motif) receptor 4Kidney+2.930.000
296TMEM91transmembrane protein 91Kidney+2.920.001
297LRRC25leucine rich repeat containing 25Kidney+2.890.005
298RFPL3SRFPL3 antisenseKidney+2.890.028
299UHRF1ubiquitin-like with PHD and ring finger domains 1Kidney+2.890.002
300DDB2damage-specific DNA binding protein 2, 48kDaKidney+2.890.000
301SIGLEC8sialic acid binding Ig-like lectin 8Kidney+2.890.001
302LAT2linker for activation of T cells family, member 2Kidney+2.890.000
303SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesinKidney+2.890.014
304BIRC5baculoviral IAP repeat containing 5Kidney+2.860.005
305CD1DCD1d moleculeKidney+2.860.000
306FAPfibroblast activation protein, alphaKidney+2.860.014
307KIF14kinesin family member 14Kidney+2.850.015
308CORO1Acoronin, actin binding protein, 1AKidney+2.850.000
309TIGITT cell immunoreceptor with Ig and ITIM domainsKidney+2.850.020
310IL21Rinterleukin 21 receptorKidney+2.850.029
311PLEKpleckstrinKidney+2.850.010
312ANGPT2angiopoietin 2Kidney+2.850.011
313IL4I1interleukin 4 induced 1Kidney+2.840.001
314SELPLGselectin P ligandKidney+2.840.001
315TYMPthymidine phosphorylaseKidney+2.830.000
316LRRC20leucine rich repeat containing 20Kidney+2.830.000
317ABCB4ATP-binding cassette, sub-family B (MDR/TAP), member 4Kidney+2.830.029
318MYBL1v-myb avian myeloblastosis viral oncogene homolog-like 1Kidney+2.830.012
319NCKAP1LNCK-associated protein 1-likeKidney+2.820.000
320MKI67marker of proliferation Ki-67Kidney+2.820.007

Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

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Compounds for genes affiliated with Renal Cell Carcinoma

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Sources:
44Novoseek, 25HMDB
See all sources

Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs4410.2MET, MME
2rapamycin4410.0CA9, VHL, MET, FLCN
3proline4410.0TFE3, MET, VHL, CA9
4oxygen44 2510.7APEH, MME, MET, VHL, CA9
5estrogen449.6CA9, VHL, MET, MME, PTPRG
6glucose449.5TFE3, MME, MET, VHL, CA9

GO Terms for genes affiliated with Renal Cell Carcinoma

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Biological processes related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of Rho protein signal transductionGO:03502410.3FLCN, KANK1
2beta-amyloid metabolic processGO:05043510.3MME, APEH
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3CA9, VHL
4positive regulation of cell adhesionGO:04578510.2FLCN, TFE3
5negative regulation of neuron projection developmentGO:01097710.1KANK1, PTPRG
6proteolysisGO:0065089.9VHL, MME, APEH
7placenta developmentGO:0018909.9MET, PBRM1

Molecular functions related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.8NONO, PTPRG, FLCN, RNF139, MME, ASPSCR1

Products for genes affiliated with Renal Cell Carcinoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Renal Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet