RCC
MCID: RNL014
MIFTS: 59

Renal Cell Carcinoma (RCC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Cell Carcinoma

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45Novus Biologicals, 32MalaCards
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Novus Biologicals:45 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards: Renal Cell Carcinoma, also known as renal cell carcinoma, stage unspecified, is related to renal clear cell carcinoma and renal oncocytoma. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways is Transcriptional misregulation in cancer. The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds estrogen and glucose have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells.

Aliases & Classifications for Renal Cell Carcinoma

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60UMLS, 8Disease Ontology, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal cell carcinoma 8 60
renal cell carcinoma, stage unspecified 8
conventional renal cell carcinoma 60
adenocarcinoma of kidney 8
hypernephroma 8
rcc 8


External Ids:

Disease Ontology8 DOID:4450
MeSH34 D002292
SNOMED-CT56 41607009, 254915003
NCIt39 C9385

Related Diseases for Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Familial Renal Cell Carcinoma
Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 370)
idRelated DiseaseScoreTop Affiliating Genes
1renal clear cell carcinoma32.1VHL, CA9, MET, MME, KRT7
2renal oncocytoma31.4KRT7, CLDN8, PRCC
3melanoma31.2CA9, MET, MME
4von hippel-lindau disease31.2VHL, MET
5kidney cancer31.0PRCC, MET, TFE3, GAL3ST1, APEH, CA9
6adenoma31.0KRT7, MET, VHL
7hemangioblastoma30.9VHL
8sarcoma30.8CA9, TFE3, MET
9papillary adenoma30.7PRCC
10adenocarcinoma30.6KRT7, MME, MET, CA9, VHL
11metanephric adenoma30.6KRT7, KANK1
12renal cell carcinoma, papillary, 130.5PRCC, TFE3
13alveolar soft part sarcoma30.4TFE3, PRCC, ASPSCR1
14cystadenoma30.3VHL, MME, KRT7
15endometrial carcinoma30.2KRT7, MME, CA9
16lung cancer30.0KRT7, MET
17papillary renal cell carcinoma11.2
18papillary carcinoma11.2
19sarcomatoid renal cell carcinoma11.0
20hereditary renal cell carcinoma10.8
21angiomyolipoma10.8
22bone carcinoma10.8
23kidney disease10.7
24cystic kidney10.7
25thyroiditis10.7
26small cell carcinoma10.7
27renal adenoma10.6
28renal cell carcinoma, clear cell, somatic10.6
29parathyroid carcinoma10.6
30adrenal carcinoma10.6
31transitional cell carcinoma10.6
32tuberous sclerosis10.6
33nonpapillary renal cell carcinoma10.6
34leiomyomatosis10.6
35clear cell renal cell carcinoma10.6
36large cell carcinoma10.5
37bladder carcinoma10.5
38xanthogranulomatous pyelonephritis10.5
39collecting duct carcinoma10.5
40glomerulonephritis10.5
41in situ carcinoma10.5
42pyelonephritis10.5
43neuroendocrine carcinoma10.5
44multilocular clear cell renal cell carcinoma10.5
45thrombocytosis10.5
46hypercalcemia10.5
47chromophobe renal cell carcinoma10.5
48mucinous tubular and spindle renal cell carcinoma10.5
49eosinophilic variant of chromophobe renal cell carcinoma10.5
50adrenocortical carcinoma10.5

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Clinical Features for Renal Cell Carcinoma

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Drugs & Therapeutics for Renal Cell Carcinoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Renal Cell Carcinoma:

32
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Liver, Prostate, Skin, Lymph node, Breast, Colon, Monocytes, Testes, Brain, Pituitary, Myeloid, Smooth muscle, Pancreas, Tongue, Heart, Cortex, B cells, Nk cells, Bone marrow, Ovary, Salivary gland, Small intestine, Spinal cord, Adrenal gland, Placenta, Skeletal muscle, Whole blood, Testis, Spleen

Animal Models for Renal Cell Carcinoma or affiliated genes

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Publications for Renal Cell Carcinoma

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50PubMed
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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4568)
idTitleAuthorsYear
1
External validation of the RENAL nephrometry score nomogram for predicting high-grade renal cell carcinoma in solid, enhancing, and small renal masses. (24013182)
2014
2
Thermal Versus Impedance-Based Ablation of Renal Cell Carcinoma: A Meta-analysis. (24091755)
2014
3
Dicer is down-regulated in clear cell renal cell carcinoma and in vitro Dicer knockdown enhances malignant phenotype transformation. (24094887)
2014
4
Fibulin-1 is down-regulated through promoter hypermethylation and suppresses renal cell carcinoma progression. (23391467)
2013
5
Diagnostic and Prognostic Role of Immunohistochemical Expression of Napsin-A Aspartic Peptidase in Clear Cell and Papillary Renal Cell Carcinoma: A Study Including 233 Primary and Metastatic Cases. (23702650)
2013
6
Resection of Isolated Renal Cell Carcinoma Metastases of the Pancreas: Outcomes from the Johns Hopkins Hospital. (24163138)
2013
7
Axitinib with or without dose titration for first-line metastatic renal-cell carcinoma: a randomised double-blind phase 2 trial. (24140184)
2013
8
Clear cell renal cell carcinoma associated microRNA expression signatures identified by an integrated bioinformatics analysis. (23841900)
2013
9
Diffusion-weighted and multiphase contrast-enhanced MRI as surrogate markers of response to neoadjuvant sunitinib in metastatic renal cell carcinoma. (24366299)
2013
10
Contemporary management of renal cell carcinoma (RCC) in Victoria: implications for longer term outcomes and costs. (24127675)
2013
11
Mayer-Rokitansky-KA1ster-Hauser syndrome accompanied by renal cell carcinoma: a case report. (23042009)
2013
12
Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma. (23967283)
2013
13
Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. (21644050)
2012
14
Centrally infiltrating renal masses on CT: differentiating intrarenal transitional cell carcinoma from centrally located renal cell carcinoma. (22451550)
2012
15
Sarcomatoid renal cell carcinoma: a comprehensive review of the biology and current treatment strategies. (22234634)
2012
16
Downregulation of SAV1 plays a role in pathogenesis of high-grade clear cell renal cell carcinoma. (22185343)
2011
17
Editorial comment on: External validation of the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score for clear-cell renal cell carcinoma in a single European centre applying routine pathology. (19062156)
2010
18
Phase I trial of metastatic renal cell carcinoma with oral capecitabine and thalidomide. (19675744)
2009
19
Favorable response to combination treatment of cimetidine, cyclooxygenase-2 inhibitor and renin-angiotensin system inhibitor in metastatic renal cell carcinoma: Report of three cases. (18786206)
2008
20
Expression of kidney-specific cadherin in chromophobe renal cell carcinoma and renal oncocytoma. (16753598)
2006
21
Pathological characterization of Kank in renal cell carcinoma. (15596059)
2005
22
Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. (15863510)
2005
23
Response of papillary renal cell carcinoma in a solitary kidney to high dose interleukin therapy. (16351658)
2005
24
Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. (15682440)
2005
25
Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma. (14981959)
2003
26
A phase I trial of CD3/CD28-activated T cells (Xcellerated T cells) and interleukin-2 in patients with metastatic renal cell carcinoma. (14506142)
2003
27
Neural cell adhesion molecule expression in renal cell carcinomas: relation to metastatic behavior. (12827605)
2003
28
MAGE-6 encodes HLA-DRbeta1*0401-presented epitopes recognized by CD4+ T cells from patients with melanoma or renal cell carcinoma. (12631591)
2003
29
VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. (12124351)
2002
30
Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma. (12202944)
2002
31
Prognostic significance of matrix metalloproteinases-2 activation ratio in renal cell carcinoma. (12445230)
2002
32
Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. (11171960)
2001
33
Molecular cloning and immunogenicity of renal cell carcinoma- associated antigen G250. (10709109)
2000
34
Sarcomatoid renal cell carcinoma of papillary origin. A case report and cytogenic evaluation. (11100068)
2000
35
Renal cell carcinoma with rhabdoid features. (11023094)
2000
36
Bilateral non-familial renal cell carcinoma. (9754765)
1998
37
Analysis of multiple renal cell adenomas and carcinomas suggests allelic loss at 3p21 to be a prerequisite for malignant development. (9258657)
1997
38
Inhalation of interleukin-2 combined with subcutaneous administration of interferon for the treatment of pulmonary metastases from renal cell carcinoma. (9256321)
1997
39
Expression of the interleukin 6 receptor in primary renal cell carcinoma. (9462266)
1997
40
Tumor localization by tumor infiltrating lymphocytes labeled with indium-111 in patients with metastatic renal cell carcinoma, melanoma, and colorectal cancer. (10851449)
1997
41
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (8660841)
1996
42
Re: Hereditary papillary renal cell carcinoma: clinical studies in 10 families. (8863608)
1996
43
Alpha-fetoprotein-producing renal cell carcinoma with increased activity of N-acetylglucosaminyl-transferase III. (8893165)
1996
44
Mapping of 29 YAC clones and identification of 3 YACs spanning the translocation t(3;8)(p14.2;q24.1) breakpoint at 8q24.1 in hereditary renal cell carcinoma. (9040788)
1996
45
Integrin expression on cell adhesion function and up-regulation of P125FAK and paxillin in metastatic renal carcinoma cells. (9023046)
1996
46
Expression patterns of multidrug-resistance (MDR1), multidrug resistance-associated protein (MRP),glutathione-S-transferase-pi (GST-pi) and DNA topoisomerase II (Topo II) genes in renal cell carcinomas and normal kidney. (8683726)
1996
47
Treatment of sarcomatoid renal cell carcinoma: is there a role for chemotherapy? (7744156)
1995
48
Sarcomatoid renal cell carcinoma. A study of its proliferative activity. (8095849)
1993
49
Benign retroperitoneal fibrosis and renal cell carcinoma. (8501806)
1993
50
Immunoreactive low-molecular-weight epidermal growth factor in urine of patients with renal cell carcinoma. (1509636)
1992

Genetic Variations for Renal Cell Carcinoma

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Expression for genes affiliated with Renal Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

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29KEGG
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Pathways related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
111.2ASPSCR1, PRCC, MET, TFE3

Compounds for genes affiliated with Renal Cell Carcinoma

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44Novoseek
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Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1estrogen4411.7PTPRG, KRT7, MME, MET, CA9, VHL
2glucose4411.6VHL, CA9, TFE3, MET, MME, KRT7
3proline4411.2MET, TFE3, CA9, VHL
4paraffin4411.1CA9, MET, MME, KRT7
5vegf4411.1VHL, CA9, MET, MME, KRT7

GO Terms for genes affiliated with Renal Cell Carcinoma

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Products for genes affiliated with Renal Cell Carcinoma

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  • Antibodies
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Sources for Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet