RCC
MCID: RNL014
MIFTS: 64

Renal Cell Carcinoma (RCC) malady

Genetic diseases, Cancer diseases, Nephrological diseases, Rare diseases categories
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Summaries for Renal Cell Carcinoma

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Novus Biologicals:45 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards based summary: Renal Cell Carcinoma, also known as adenocarcinoma of kidney, is related to renal oncocytoma and von hippel-lindau disease. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways are Regulation of Hypoxia-inducible Factor (HIF) by Oxygen and Renal cell carcinoma. The drugs medroxyprogesterone and medroxyprogesterone acetate and the compounds crcs and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells.

Disease Ontology:8 A renal carcinoma that has material basis in the lining of the proximal convoluted renal tubule of the kidney.

Aliases & Classifications for Renal Cell Carcinoma

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Renal Cell Carcinoma, Aliases & Descriptions:

Name: Renal Cell Carcinoma 30 8 62
Adenocarcinoma of Kidney 8 62
Conventional Renal Cell Carcinoma 62
 
Hypernephroma 8
Rcc 8


Classifications:



External Ids:

Disease Ontology8 DOID:4450
MeSH34 D002292
SNOMED-CT57 41607009, 254915003
NCIt39 C9385

Related Diseases for Renal Cell Carcinoma

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Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 384)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma31.9PRCC, FLCN, CLDN8
2von hippel-lindau disease31.5VHL, MET
3kidney cancer31.5VHL, FLCN
4sarcoma31.3CA9, MET, TFE3
5alveolar soft part sarcoma31.1ASPSCR1, PRCC, TFE3
6renal clear cell carcinoma31.0VHL, CA9, MME, MET
7cystadenoma30.9MME, VHL
8clear cell renal cell carcinoma11.4
9papillary renal cell carcinoma11.3
10chromophobe renal cell carcinoma11.2
11sarcomatoid renal cell carcinoma11.0
12endotheliitis11.0
13multilocular cystic renal cell carcinoma10.9
14hypoxia10.9
15clear cell papillary renal cell carcinoma10.9
16melanoma10.9
17angiomyolipoma10.8
18kidney disease10.8
19familial renal cell carcinoma10.8
20thyroiditis10.7
21hereditary renal cell carcinoma10.7
22horseshoe kidney10.7
23adenoma10.7
24renal cell carcinoma, clear cell, somatic10.7
25hemangioblastoma10.7
26leiomyomatosis10.7
27cystic kidney10.7
28tuberous sclerosis10.6
29pyelonephritis10.6
30nonpapillary renal cell carcinoma10.6
31xanthogranulomatous pyelonephritis10.6
32chromophil renal cell carcinoma10.6
33glomerulonephritis10.6
34collecting duct carcinoma10.6
35thrombocytosis10.5
36hypercalcemia10.5
37pancreatitis10.5
38hepatitis10.5
39leukemia10.5
40paraneoplastic syndromes10.5
41wilms tumor10.5
42adenocarcinoma10.5
43prostatitis10.5
44renal cell carcinoma 410.5
45metanephric adenoma10.5
46polycystic kidney disease10.5
47adrenocortical carcinoma10.5
48mucinous tubular and spindle cell carcinoma10.5
49spindle cell carcinoma10.4
50transitional cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Symptoms for Renal Cell Carcinoma

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Drugs & Therapeutics for Renal Cell Carcinoma

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Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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MalaCards organs/tissues related to Renal Cell Carcinoma:

32
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Lymph node, Liver, Skin, Prostate, Monocytes, Breast, Testes, Brain, Neutrophil, Cortex, Colon, Myeloid, Smooth muscle, Bone marrow, Heart, Pancreas, Nk cells, Spinal cord, Small intestine, Adrenal gland, B cells, Tongue, Pituitary, Whole blood, Spleen, Skeletal muscle, Salivary gland, Ovary, Placenta, Testis

Animal Models for Renal Cell Carcinoma or affiliated genes

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Publications for Renal Cell Carcinoma

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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4259)
idTitleAuthorsYear
1
Urologic Pathology: CBS25-1 CLEAR CELL PAPILLARY RENAL CELL CARCINOMA. (25188173)
2014
2
Small tumour size is associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. (24060356)
2014
3
The molecular biology of renal cell carcinoma. (23972705)
2013
4
Comparative expression profiling for human endoplasmic reticulum-resident aminopeptidases 1 and 2 in normal kidney versus distinct renal cell carcinoma subtypes. (23696916)
2013
5
Words of wisdom: re: multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. (23272732)
2013
6
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
7
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
8
Double jeopardy? Renal-sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma. (23914271)
2013
9
Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas. (23799843)
2013
10
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
11
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
12
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
13
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. (21632985)
2011
14
Progress in nephron sparing therapy for renal cell carcinoma and von Hippel-Lindau disease. (21496837)
2011
15
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. (20103651)
2010
16
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. (20121140)
2010
17
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
18
Increased activated Akt expression in renal cell carcinomas and prognosis. (18774962)
2009
19
Imprint cytologic features in renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in an adult: a case report. (20014561)
2009
20
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
21
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. (18709334)
2008
22
Renal cell carcinoma and antiangiogenic therapies]. (18035517)
2008
23
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
24
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. (17605814)
2007
25
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)
2006
26
Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features. (17121199)
2006
27
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
28
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. (15625368)
2005
29
Experimental study on induction of renal cell carcinoma apoptosis by antisense oligonucleotide targeting survivin. (15641694)
2004
30
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. (14654968)
2004
31
Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma. (14981959)
2003
32
Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma. (12963978)
2003
33
Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. (11369057)
2001
34
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. (11139287)
2000
35
Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma. (10537342)
1999
36
Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma. (9205056)
1997
37
Temporal arteritis presenting with concomitant renal cell carcinoma. (19078210)
1997
38
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (8660841)
1996
39
Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal cell carcinomas and effects on expression of interleukin-6 or interleukin-6 receptor. (7861551)
1995
40
Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. (8198979)
1994
41
Sarcomatoid renal cell carcinoma. A study of its proliferative activity. (8095849)
1993
42
Immunological study of interferon-gamma therapy for advanced renal cell carcinoma]. (1288223)
1992
43
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
44
Immune modulating effects of low doses of cyclophosphamide and keyhole limpet hemocyanin on peripheral blood immune parameters in patients with metastatic renal cell carcinoma. (1598724)
1992
45
Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma. (1795011)
1991
46
In vivo antiproliferative effects of gamma-interferon and tumor necrosis factor alpha in a rat renal cell carcinoma model system. (2111411)
1990
47
Comparative biochemical and immunological studies on gamma-glutamyltransferases from human kidney and renal cell carcinoma applying monoclonal antibodies. (1979761)
1990
48
Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma. A randomized trial. (2185803)
1990
49
Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. (2894030)
1988
50
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977

Variations for Renal Cell Carcinoma

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Expression for genes affiliated with Renal Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

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Compounds for genes affiliated with Renal Cell Carcinoma

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Sources:
44Novoseek, 24HMDB
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Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs4410.2MET, MME
2rapamycin4410.0FLCN, MET, VHL, CA9
3proline4410.0MET, CA9, VHL, TFE3
4oxygen44 2410.7VHL, CA9, APEH, MET, MME
5estrogen449.6CA9, VHL, MET, MME, PTPRG
6glucose449.5CA9, VHL, MET, MME, TFE3

GO Terms for genes affiliated with Renal Cell Carcinoma

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Biological processes related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of Rho protein signal transductionGO:03502410.3FLCN, KANK1
2beta-amyloid metabolic processGO:05043510.3MME, APEH
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3CA9, VHL
4positive regulation of cell adhesionGO:04578510.2FLCN, TFE3
5negative regulation of neuron projection developmentGO:01097710.1KANK1, PTPRG
6proteolysisGO:0065089.9VHL, MME, APEH
7placenta developmentGO:0018909.9MET, PBRM1

Molecular functions related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.8NONO, PTPRG, FLCN, RNF139, MME, ASPSCR1

Products for genes affiliated with Renal Cell Carcinoma

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  • Antibodies
  • Proteins
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Sources for Renal Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet