RCC
MCID: RNL014
MIFTS: 62

Renal Cell Carcinoma (RCC) malady

Genetic diseases, Cancer diseases, Nephrological diseases, Rare diseases categories
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Summaries for Renal Cell Carcinoma

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46Novus Biologicals, 33MalaCards
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Novus Biologicals:46 Renal cell carcinoma originates in the proximal renal tube and is the most common form of kidney cancer. Renal cell carcinoma is resistant to radiation therapy and chemotherapy, however some cases respond to immunotherapy. Interleukin-2 has produced remission in some patients, as has functional restoration of the VHL gene.

MalaCards: Renal Cell Carcinoma, also known as renal cell carcinoma, stage unspecified, is related to renal oncocytoma and von hippel-lindau disease. An important gene associated with Renal Cell Carcinoma is DIRC2 (disrupted in renal carcinoma 2), and among its related pathways are Regulation of Hypoxia-inducible Factor (HIF) by Oxygen and Renal cell carcinoma. The drugs hydroxyurea and interferon alfa-2a and the compounds crcs and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and t cells.

Aliases & Classifications for Renal Cell Carcinoma

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8Disease Ontology, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:



Aliases & Descriptions:

renal cell carcinoma 8 62
renal cell carcinoma, stage unspecified 8
conventional renal cell carcinoma 62
adenocarcinoma of kidney 8
hypernephroma 8
rcc 8


External Ids:

Disease Ontology8 DOID:4450
MeSH35 D002292
SNOMED-CT58 41607009, 254915003
NCIt40 C9385

Related Diseases for Renal Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases in the Renal Cell Carcinoma family:

Renal Clear Cell Carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 373)
idRelated DiseaseScoreTop Affiliating Genes
1renal oncocytoma31.5PRCC, FLCN, CLDN8
2von hippel-lindau disease31.3VHL, MET
3kidney cancer31.1VHL, FLCN
4sarcoma30.9CA9, MET, TFE3
5renal clear cell carcinoma30.7VHL, CA9, MME, MET
6alveolar soft part sarcoma30.6ASPSCR1, PRCC, TFE3
7cystadenoma30.5MME, VHL
8clear cell renal cell carcinoma11.4
9papillary renal cell carcinoma11.3
10chromophobe renal cell carcinoma11.2
11endotheliitis11.0
12sarcomatoid renal cell carcinoma11.0
13hypoxia10.9
14multilocular cystic renal cell carcinoma10.9
15melanoma10.8
16angiomyolipoma10.8
17clear cell papillary renal cell carcinoma10.8
18familial renal cell carcinoma10.7
19kidney disease10.7
20thyroiditis10.7
21horseshoe kidney10.7
22adenoma10.7
23renal cell carcinoma, clear cell, somatic10.7
24hereditary renal cell carcinoma10.7
25cystic kidney10.6
26hemangioblastoma10.6
27tuberous sclerosis10.6
28leiomyomatosis10.6
29nonpapillary renal cell carcinoma10.6
30chromophil renal cell carcinoma10.6
31xanthogranulomatous pyelonephritis10.5
32glomerulonephritis10.5
33pyelonephritis10.5
34thrombocytosis10.5
35hypercalcemia10.5
36collecting duct carcinoma10.5
37hepatitis10.5
38leukemia10.5
39pancreatitis10.5
40paraneoplastic syndromes10.5
41adenocarcinoma10.5
42prostatitis10.5
43wilms tumor10.5
44renal cell carcinoma 410.5
45metanephric adenoma10.4
46mucinous tubular and spindle cell carcinoma10.4
47spindle cell carcinoma10.4
48polycystic kidney disease10.4
49adrenocortical carcinoma10.4
50transitional cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Cell Carcinoma:



Diseases related to renal cell carcinoma

Symptoms for Renal Cell Carcinoma

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Drugs & Therapeutics for Renal Cell Carcinoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Genetic Tests for Renal Cell Carcinoma

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Anatomical Context for Renal Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Renal Cell Carcinoma:

33
Kidney, Endothelial, T cells, Bone, Thyroid, Lung, Liver, Lymph node, Prostate, Skin, Testes, Breast, Monocytes, Brain, Colon, Myeloid, Cortex, Smooth muscle, Pituitary, Bone marrow, Pancreas, Heart, Spinal cord, B cells, Small intestine, Tongue, Adrenal gland, Nk cells, Whole blood, Spleen, Skeletal muscle, Testis, Placenta, Ovary, Salivary gland

Animal Models for Renal Cell Carcinoma or affiliated genes

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Publications for Renal Cell Carcinoma

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52PubMed
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Articles related to Renal Cell Carcinoma:

(show top 50)    (show all 4105)
idTitleAuthorsYear
1
Small tumour size is associated with new-onset chronic kidney disease after radical nephrectomy in patients with renal cell carcinoma. (24060356)
2014
2
The molecular biology of renal cell carcinoma. (23972705)
2013
3
Words of wisdom: re: multilocular cystic renal cell carcinoma with focus on clinical and pathobiological aspects. (23272732)
2013
4
Attenuation of krA1ppel-like factor 4 facilitates carcinogenesis by inducing g1/s phase arrest in clear cell renal cell carcinoma. (23861801)
2013
5
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
6
Double jeopardy? Renal-sparing management of simultaneous ipsilateral renal cell carcinoma and urothelial carcinoma. (23914271)
2013
7
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
8
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
9
Specific miRNA signatures are associated with metastasis and poor prognosis in clear cell renal cell carcinoma. (21229250)
2011
10
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinoma. (21632985)
2011
11
Progress in nephron sparing therapy for renal cell carcinoma and von Hippel-Lindau disease. (21496837)
2011
12
Preliminary study of whole-body diffusion-weighted imaging in detecting pulmonary metastatic lesions from clear cell renal cell carcinoma: comparison with CT. (21903870)
2011
13
Interleukin-8 mediates resistance to antiangiogenic agent sunitinib in renal cell carcinoma. (20103651)
2010
14
Combined blood/tissue analysis for cancer biomarker discovery: application to renal cell carcinoma. (20121140)
2010
15
A proposal for reclassification of the Fuhrman grading system in patients with clear cell renal cell carcinoma. (19573980)
2009
16
Increased activated Akt expression in renal cell carcinomas and prognosis. (18774962)
2009
17
Imprint cytologic features in renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in an adult: a case report. (20014561)
2009
18
Onconeuronal cerebellar degeneration-related antigen, Cdr2, is strongly expressed in papillary renal cell carcinoma and leads to attenuated hypoxic response. (19581925)
2009
19
MMP-13 is over-expressed in renal cell carcinoma bone metastasis and is induced by TGF-beta1. (18709334)
2008
20
Renal cell carcinoma and antiangiogenic therapies]. (18035517)
2008
21
Organ-confined clear cell renal cell carcinoma: the prognostic impact of microvascular invasion, nuclear grade and tumour size. (19133004)
2008
22
Activation of PI3K is associated with reduced survival in renal cell carcinoma. (18587247)
2008
23
Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins. (17605814)
2007
24
Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element. (16644575)
2006
25
Renal cell carcinoma with an Xp11.2 translocation in a 16-year-old girl: a case report with cytological features. (17121199)
2006
26
Chromophobe renal cell carcinoma with focal papillary configuration, nuclear basaloid arrangement and stromal osseous metaplasia containing fatty bone marrow element. (15910607)
2005
27
Randomized phase III trial of high-dose interleukin-2 versus subcutaneous interleukin-2 and interferon in patients with metastatic renal cell carcinoma. (15625368)
2005
28
Experimental study on induction of renal cell carcinoma apoptosis by antisense oligonucleotide targeting survivin. (15641694)
2004
29
Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor. (14654968)
2004
30
Disruption of basement membrane, extracellular matrix metalloproteinases and E-cadherin in renal-cell carcinoma. (14981959)
2003
31
Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma. (12963978)
2003
32
Interleukin-6, tumour necrosis factor alpha and interleukin-1beta in patients with renal cell carcinoma. (11986770)
2002
33
Proliferating cell nuclear antigen and epidermal growth factor receptor (EGFr) status in renal cell carcinoma patients with polysomy of chromosome 7. (11369057)
2001
34
Sensitivity to TRAIL/APO-2L-mediated apoptosis in human renal cell carcinomas and its enhancement by topotecan. (11139287)
2000
35
Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma. (10537342)
1999
36
Loss of imprinting of the insulin-like growth factor II gene in renal cell carcinoma. (9205056)
1997
37
Temporal arteritis presenting with concomitant renal cell carcinoma. (19078210)
1997
38
An improved circularly permuted interleukin 4-toxin is highly cytotoxic to human renal cell carcinoma cells. Introduction of gamma c chain in RCC cells does not improve sensitivity. (8660841)
1996
39
Inhibitory effect of dexamethasone and progesterone in vitro on proliferation of human renal cell carcinomas and effects on expression of interleukin-6 or interleukin-6 receptor. (7861551)
1995
40
Subcutaneous low-dose recombinant interleukin 2 and alpha-interferon in patients with metastatic renal cell carcinoma. (8198979)
1994
41
Sarcomatoid renal cell carcinoma. A study of its proliferative activity. (8095849)
1993
42
Immunological study of interferon-gamma therapy for advanced renal cell carcinoma]. (1288223)
1992
43
Cytokine-induced gene expression of interleukin-8 in human transitional cell carcinomas and renal cell carcinomas. (1739130)
1992
44
Immune modulating effects of low doses of cyclophosphamide and keyhole limpet hemocyanin on peripheral blood immune parameters in patients with metastatic renal cell carcinoma. (1598724)
1992
45
Ifosfamide, vindesine and recombinant alpha-interferon combination chemotherapy for metastatic renal cell carcinoma. (1795011)
1991
46
In vivo antiproliferative effects of gamma-interferon and tumor necrosis factor alpha in a rat renal cell carcinoma model system. (2111411)
1990
47
Comparative biochemical and immunological studies on gamma-glutamyltransferases from human kidney and renal cell carcinoma applying monoclonal antibodies. (1979761)
1990
48
Recombinant leukocyte interferon alpha-2a and medroxyprogesterone in advanced renal cell carcinoma. A randomized trial. (2185803)
1990
49
Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma. (2894030)
1988
50
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977

Variations for Renal Cell Carcinoma

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Expression for genes affiliated with Renal Cell Carcinoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Cell Carcinoma

Search GEO for disease gene expression data for Renal Cell Carcinoma.

Pathways for genes affiliated with Renal Cell Carcinoma

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50PathCards, 55Reactome, 30KEGG
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Compounds for genes affiliated with Renal Cell Carcinoma

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45Novoseek, 24HMDB
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Compounds related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1crcs4510.2MET, MME
2rapamycin4510.0CA9, VHL, MET, FLCN
3proline4510.0TFE3, MET, VHL, CA9
4oxygen45 2410.7APEH, MME, MET, VHL, CA9
5estrogen459.6CA9, VHL, MET, MME, PTPRG
6glucose459.5TFE3, MME, MET, VHL, CA9

GO Terms for genes affiliated with Renal Cell Carcinoma

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16Gene Ontology
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Biological processes related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of Rho protein signal transductionGO:03502410.3FLCN, KANK1
2beta-amyloid metabolic processGO:05043510.3MME, APEH
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.3CA9, VHL
4positive regulation of cell adhesionGO:04578510.2FLCN, TFE3
5negative regulation of neuron projection developmentGO:01097710.1KANK1, PTPRG
6proteolysisGO:0065089.9VHL, MME, APEH
7placenta developmentGO:0018909.9MET, PBRM1

Molecular functions related to Renal Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055158.8NONO, PTPRG, FLCN, RNF139, MME, ASPSCR1

Products for genes affiliated with Renal Cell Carcinoma

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Sources for Renal Cell Carcinoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet