MCID: RNL101
MIFTS: 59

Renal Cell Carcinoma, Papillary malady

Genetic diseases, Rare diseases, Nephrological diseases, Cancer diseases categories

Aliases & Classifications for Renal Cell Carcinoma, Papillary

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Sources:
45OMIM, 30LifeMap Discovery®, 9Disease Ontology, 10diseasecard, 41NIH Rare Diseases, 20GeneTests, 11DISEASES, 47Orphanet, 22GTR, 60UMLS, 33MeSH, 55SNOMED-CT, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Renal Cell Carcinoma, Papillary, Aliases & Descriptions:

Name: Renal Cell Carcinoma, Papillary 45 10
Papillary Renal Cell Carcinoma 30 9 41 11 47 60
Renal Cell Carcinoma, Papillary, 1 45 10 22
Papillary Kidney Carcinoma 9 20
Renal Cell Carcinoma, Papillary, 1, Familial and Somatic 45
Papillary Renal Cell Carcinoma, Bilateral - 41
Papillary Renal Cell Carcinoma, Sporadic - 41
Papillary Renal Cell Carcinoma, Multiple - 41
Papillary Renal Cell Carcinoma, Familial - 41
Papillary Renal Cell Carcinoma, Familial 60
 
Papillary Renal Cell Carcinoma, Sporadic 60
Familial Papillary Renal Cell Carcinoma 41
Sporadic Papillary Renal Cell Carcinoma 9
Papillary Renal Carcinoma, Malignant - 41
Renal Cell Carcinoma, Xp11-Associated 45
Papillary Renal Cell Adenocarcinoma 47
Chromophil Carcinoma of Kidney 9
Renal Cell Carcinoma 60
Renal Adenocarcinoma 41
Rccp 41


Classifications:



External Ids:

Disease Ontology9 DOID:4465
NCIt38 C6975
SNOMED-CT55 4797003
Orphanet47 319298
ICD10 via Orphanet26 C64
UMLS via Orphanet61 C1306837

Summaries for Renal Cell Carcinoma, Papillary

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OMIM:45 Xp11 translocation renal cell carcinomas (RCCX1) are a group of neoplasms distinguished by chromosomal translocations... (300854) more...

MalaCards based summary: Renal Cell Carcinoma, Papillary, also known as papillary renal cell carcinoma, is related to renal cell carcinoma and sarcoma, and has symptoms including somatic mutation, renal cell carcinoma and autosomal dominant inheritance. An important gene associated with Renal Cell Carcinoma, Papillary is MET (met proto-oncogene), and among its related pathways are Glioma and Regulation of retinoblastoma protein. The drugs thalidomide and interferon alfa-2a have been mentioned in the context of this disorder. Affiliated tissues include kidney, t cells and bone, and related mouse phenotype craniofacial.

Disease Ontology:9 A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors.

Description from OMIM:45 605074

Related Diseases for Renal Cell Carcinoma, Papillary

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Diseases in the Renal Cell Carcinoma, Papillary family:

Hereditary Papillary Renal Cell Carcinoma

Diseases related to Renal Cell Carcinoma, Papillary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma31.1MET, PRCC, TFE3
2sarcoma30.0MET, TFE3
3kidney cancer29.5TFE3, PRCC, MET, MITF
4hereditary papillary renal cell carcinoma10.7
5adenoma10.7
6metanephric adenoma10.6
7clear cell renal cell carcinoma10.6
8spindle cell carcinoma10.6
9mucinous tubular and spindle cell carcinoma10.6
10leiomyomatosis and renal cell cancer10.5
11angiomyolipoma10.5
12gastrointestinal stromal tumor10.5
13kidney disease10.5
14thyroiditis10.5
15tubulocystic carcinoma10.5
16polycystic kidney disease10.4
17papillary adenoma10.4
18pyelonephritis10.4
19endotheliitis10.4
20von hippel-lindau syndrome10.2
21hyperparathyroidism-jaw tumor syndrome10.2
22chromophobe renal cell carcinoma10.2
23glomerulonephritis10.2
24renal oncocytoma10.2
25cystadenoma10.2
26adenoiditis10.2
27xanthogranulomatous pyelonephritis10.2
28collecting duct carcinoma10.2
29crescentic glomerulonephritis10.2
30adenocarcinoma10.2
31cervicitis10.2
32cystic kidney10.2
33glomerulosclerosis10.2
34leiomyomatosis10.2
35lipomatosis10.2
36lymphopenia10.2
37neuropathy10.2
38vaginitis10.2
39pten hamartoma tumor syndrome10.2
40castleman's disease10.2
41cerebellar degeneration10.2
42chromophil renal cell carcinoma10.2
43horseshoe kidney10.2
44retroperitoneal fibrosis10.2
45hypoxia10.2
46teratoma10.2
47translocation renal cell carcinoma10.2
48clear cell papillary renal cell carcinoma10.2
49renal clear cell carcinoma10.2MET
50oxyphilic adenoma10.0PRCC, TFE3

Graphical network of the top 20 diseases related to Renal Cell Carcinoma, Papillary:



Diseases related to renal cell carcinoma, papillary

Symptoms for Renal Cell Carcinoma, Papillary

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Clinical features from OMIM:

605074,300854

HPO human phenotypes related to Renal Cell Carcinoma, Papillary:

id Description Frequency HPO Source Accession
1 somatic mutation HP:0001428
2 renal cell carcinoma HP:0005584
3 autosomal dominant inheritance HP:0000006
4 incomplete penetrance HP:0003829
5 papillary renal cell carcinoma HP:0006766

Drugs & Therapeutics for Renal Cell Carcinoma, Papillary

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Genetic Tests for Renal Cell Carcinoma, Papillary

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Genetic tests related to Renal Cell Carcinoma, Papillary:

id Genetic test Affiliating Genes
1 Papillary Renal Carcinoma20 MET
2 Renal Cell Carcinoma, Papillary, 122

Anatomical Context for Renal Cell Carcinoma, Papillary

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MalaCards organs/tissues related to Renal Cell Carcinoma, Papillary:

31
Kidney, T cells, Bone, Brain, Liver, Breast, Prostate, B cells

Animal Models for Renal Cell Carcinoma, Papillary or affiliated genes

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MGI Mouse Phenotypes related to Renal Cell Carcinoma, Papillary:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9MITF, MET, TFE3

Publications for Renal Cell Carcinoma, Papillary

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Variations for Renal Cell Carcinoma, Papillary

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UniProtKB/Swiss-Prot genetic disease variations for Renal Cell Carcinoma, Papillary:

62 (show all 15)
id Symbol AA change Variation ID SNP ID
1METp.Met1131ThrVAR_006286
2METp.Val1188LeuVAR_006287
3METp.Leu1195ValVAR_006288
4METp.Val1220IleVAR_006289
5METp.Asp1228AsnVAR_006290
6METp.Asp1228HisVAR_006291
7METp.Tyr1230CysVAR_006292
8METp.Tyr1230HisVAR_006293
9METp.Met1250ThrVAR_006294
10METp.Val1092IleVAR_032485
11METp.His1094LeuVAR_032486
12METp.His1094ArgVAR_032487
13METp.His1094TyrVAR_032488
14METp.His1106AspVAR_032489
15METp.Tyr1230AspVAR_032491

Clinvar genetic disease variations for Renal Cell Carcinoma, Papillary:

6
id Gene Variation Type Significance SNP ID Assembly Location
1METNM_001127500.1(MET): c.3446T> C (p.Met1149Thr)single nucleotide variantPathogenicrs121913668GRCh37Chr 7, 116418881: 116418881
2METNM_001127500.1(MET): c.3616G> T (p.Val1206Leu)single nucleotide variantPathogenicrs121913669GRCh37Chr 7, 116422081: 116422081
3METNM_001127500.1(MET): c.3712G> A (p.Val1238Ile)single nucleotide variantPathogenicrs121913670GRCh37Chr 7, 116423383: 116423383
4METNM_001127500.1(MET): c.3736G> A (p.Asp1246Asn)single nucleotide variantPathogenicrs121913671GRCh37Chr 7, 116423407: 116423407
5METNM_001127500.1(MET): c.3743A> G (p.Tyr1248Cys)single nucleotide variantPathogenicrs121913246GRCh37Chr 7, 116423414: 116423414
6METNM_001127500.1(MET): c.3637C> G (p.Leu1213Val)single nucleotide variantPathogenicrs121913673GRCh37Chr 7, 116422102: 116422102
7METNM_001127500.1(MET): c.3335A> G (p.His1112Arg)single nucleotide variantPathogenicrs121913243GRCh37Chr 7, 116417464: 116417464

Cosmic variations for Renal Cell Carcinoma, Papillary:

7 (show all 45)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
1690METkidney,NS,carcinoma,papillary renal cell carcinoma3
2704METkidney,NS,carcinoma,papillary renal cell carcinoma3
3698METkidney,NS,carcinoma,papillary renal cell carcinoma3
4689METkidney,NS,carcinoma,papillary renal cell carcinoma3
5484661METkidney,NS,carcinoma,papillary renal cell carcinoma3
6697METkidney,NS,carcinoma,papillary renal cell carcinoma3
7696METkidney,NS,carcinoma,papillary renal cell carcinoma3
8688METkidney,NS,carcinoma,papillary renal cell carcinoma3
9691METkidney,NS,carcinoma,papillary renal cell carcinoma3
1017807VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1114311VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1218346VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1317808VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1430286VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1525673VHLkidney,NS,carcinoma,papillary renal cell carcinoma3
1610709TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
1743697TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
1843850TP53kidney,NS,carcinoma,papillary renal cell carcinoma3
19760PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
20763PIK3CAkidney,NS,carcinoma,papillary renal cell carcinoma3
21718FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
223993568FGFR3kidney,NS,carcinoma,papillary renal cell carcinoma3
23462BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
241131BRAFkidney,NS,carcinoma,papillary renal cell carcinoma3
2521945EGFRkidney,NS,carcinoma,papillary renal cell carcinoma3
2614060ERBB2kidney,NS,carcinoma,papillary renal cell carcinoma3
271583146DNMT3Akidney,NS,carcinoma,papillary renal cell carcinoma3
281181978ADARB1kidney,NS,carcinoma,papillary renal cell carcinoma3
29742462GFRALkidney,NS,carcinoma,papillary renal cell carcinoma3
30375283ANKHD1-EIF4EBP3kidney,NS,carcinoma,papillary renal cell carcinoma3
31274461CDC73kidney,NS,carcinoma,papillary renal cell carcinoma3
32302052DHX9kidney,NS,carcinoma,papillary renal cell carcinoma3
33375284ANKHD1kidney,NS,carcinoma,papillary renal cell carcinoma3
34964299MAP2K5kidney,NS,carcinoma,papillary renal cell carcinoma3
35485065RHEBkidney,NS,carcinoma,papillary renal cell carcinoma3
361222993RAD23Bkidney,NS,carcinoma,papillary renal cell carcinoma3
37487039SCAIkidney,NS,carcinoma,papillary renal cell carcinoma3
38110414SMARCB1kidney,NS,carcinoma,papillary renal cell carcinoma3
391268384TP63kidney,NS,carcinoma,papillary renal cell carcinoma3
401360764SOX5kidney,NS,carcinoma,papillary renal cell carcinoma3
415260PTENkidney,NS,carcinoma,papillary renal cell carcinoma3
42485575PMS2P11kidney,NS,carcinoma,papillary renal cell carcinoma3
43521KRASkidney,NS,carcinoma,papillary renal cell carcinoma3
44188258HIVEP3kidney,NS,carcinoma,papillary renal cell carcinoma3
45163384PDGFRAkidney,NS,carcinoma,papillary renal cell carcinoma3

Expression for genes affiliated with Renal Cell Carcinoma, Papillary

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LifeMap Discovery
Genes differentially expressed in tissues of Renal Cell Carcinoma, Papillary patients vs. healthy controls: 30 (show all 276)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1SLC12A1solute carrier family 12 (sodium/potassium/chloride transporter), member 1Kidney-9.350.000
2CALB1calbindin 1, 28kDaKidney-8.950.000
3FXYD4FXYD domain containing ion transport regulator 4Kidney-8.290.000
4CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)Kidney+8.250.000
5CLDN8claudin 8Kidney-8.200.000
6KCNJ1potassium inwardly-rectifying channel, subfamily J, member 1Kidney-8.200.000
7NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin)Kidney-8.180.000
8MUC15mucin 15, cell surface associatedKidney-7.960.000
9SCNN1Gsodium channel, non-voltage-gated 1, gamma subunitKidney-7.910.000
10HPD4-hydroxyphenylpyruvate dioxygenaseKidney-7.780.000
11FABP1fatty acid binding protein 1, liverKidney-7.740.000
12DNASE1deoxyribonuclease IKidney-7.590.000
13AQP6aquaporin 6, kidney specificKidney+7.570.000
14SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13Kidney-7.290.000
15ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Kidney-7.130.000
16PCP4Purkinje cell protein 4Kidney-7.130.000
17KNG1kininogen 1Kidney-7.120.000
18TYRP1tyrosinase-related protein 1Kidney-7.100.000
19FGF9fibroblast growth factor 9Kidney-6.990.000
20EGFepidermal growth factorKidney-6.920.000
21TMEM255Atransmembrane protein 255AKidney+6.840.000
22RALYLRALY RNA binding protein-likeKidney-6.810.000
23PVALBparvalbuminKidney-6.730.000
24KCNJ10potassium inwardly-rectifying channel, subfamily J, member 10Kidney-6.690.000
25TMEM213transmembrane protein 213Kidney-6.640.000
26SLC22A8solute carrier family 22 (organic anion transporter), member 8Kidney-6.580.000
27IRX2iroquois homeobox 2Kidney-6.560.000
28SLC26A7solute carrier family 26 (anion exchanger), member 7Kidney-6.560.000
29SLC4A1solute carrier family 4 (anion exchanger), member 1 (Diego blood group)Kidney-6.530.000
30GPC5glypican 5Kidney-6.530.000
31RHCGRh family, C glycoproteinKidney-6.520.000
32SOSTsclerostinKidney-6.510.000
33SFRP1secreted frizzled-related protein 1Kidney-6.490.000
34HEPACAM2HEPACAM family member 2Kidney-6.450.000
35HHATLhedgehog acyltransferase-likeKidney+6.410.000
36NELL1NEL-like 1 (chicken)Kidney-6.380.000
37SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Kidney-6.340.000
38RAB25RAB25, member RAS oncogene familyKidney-6.320.000
39TMPRSS2transmembrane protease, serine 2Kidney-6.310.000
40TMEM52Btransmembrane protein 52BKidney-6.280.000
41ERBB4v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4Kidney-6.260.000
42SOSTDC1sclerostin domain containing 1Kidney-6.250.000
43SH3GL2SH3-domain GRB2-like 2Kidney-6.160.000
44ALDOBaldolase B, fructose-bisphosphateKidney-6.130.003
45UMODuromodulinKidney-6.070.000
46LOC284578uncharacterized LOC284578Kidney-6.020.000
47ESRRBestrogen-related receptor betaKidney-5.990.000
48SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Kidney-5.960.001
49TSPAN8tetraspanin 8Kidney-5.960.000
50WNK4WNK lysine deficient protein kinase 4Kidney-5.940.000
51DIO1deiodinase, iodothyronine, type IKidney-5.930.000
52SFTPBsurfactant protein BKidney+5.770.000
53ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3Kidney-5.730.000
54NOS1nitric oxide synthase 1 (neuronal)Kidney-5.730.000
55BAALCbrain and acute leukemia, cytoplasmicKidney+5.690.000
56SIM2single-minded family bHLH transcription factor 2Kidney-5.660.000
57XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundKidney-5.650.000
58G6PCglucose-6-phosphatase, catalytic subunitKidney-5.640.013
59SCNN1Asodium channel, non-voltage-gated 1 alpha subunitKidney-5.630.002
60ATP6V1B1ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1Kidney-5.620.000
61HSD11B2hydroxysteroid (11-beta) dehydrogenase 2Kidney-5.600.000
62ANO4anoctamin 4Kidney+5.560.000
63LIMS3LIM and senescent cell antigen-like domains 3Kidney+5.530.000
64HS6ST2heparan sulfate 6-O-sulfotransferase 2Kidney-5.520.000
65DPEP1dipeptidase 1 (renal)Kidney-5.490.000
66SLC4A9solute carrier family 4, sodium bicarbonate cotransporter, member 9Kidney-5.490.000
67GPSM2G-protein signaling modulator 2Kidney+5.480.000
68C16orf89chromosome 16 open reading frame 89Kidney-5.480.000
69CTXN3cortexin 3Kidney-5.470.001
70LOC285556uncharacterized LOC285556Kidney-5.470.000
71FAM3Bfamily with sequence similarity 3, member BKidney-5.430.000
72HRGhistidine-rich glycoproteinKidney-5.400.000
73PLGplasminogenKidney-5.400.000
74ENPP6ectonucleotide pyrophosphatase/phosphodiesterase 6Kidney-5.380.000
75MST1Lmacrophage stimulating 1-likeKidney-5.340.000
76KCNG1potassium voltage-gated channel, subfamily G, member 1Kidney+5.330.000
77PAHphenylalanine hydroxylaseKidney-5.320.003
78MFSD4major facilitator superfamily domain containing 4Kidney-5.310.000
79SCNN1Bsodium channel, non-voltage-gated 1, beta subunitKidney-5.290.000
80PRDM16PR domain containing 16Kidney-5.290.000
81FAM151Afamily with sequence similarity 151, member AKidney-5.290.004
82MALmal, T-cell differentiation proteinKidney-5.290.001
83CA10carbonic anhydrase XKidney-5.290.000
84GRM1glutamate receptor, metabotropic 1Kidney-5.280.000
85RANBP3LRAN binding protein 3-likeKidney-5.270.000
86CLCNKBchloride channel, voltage-sensitive KbKidney-5.260.000
87NRKNik related kinaseKidney-5.260.000
88VTCN1V-set domain containing T cell activation inhibitor 1Kidney-5.260.000
89ESRP1epithelial splicing regulatory protein 1Kidney-5.250.001
90MAPRE3microtubule-associated protein, RP/EB family, member 3Kidney+5.220.000
91CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 2Kidney-5.210.000
92ZNF44zinc finger protein 44Kidney-5.190.000
93ADAMTSL1ADAMTS-like 1Kidney+5.180.004
94DUSP9dual specificity phosphatase 9Kidney-5.150.000
95AQP2aquaporin 2 (collecting duct)Kidney-5.150.000
96SLC22A7solute carrier family 22 (organic anion transporter), member 7Kidney-5.130.008
97VGLL1vestigial-like family member 1Kidney-5.120.000
98DMRT2doublesex and mab-3 related transcription factor 2Kidney-5.110.000
99TACSTD2tumor-associated calcium signal transducer 2Kidney-5.110.000
100CASRcalcium-sensing receptorKidney-5.110.000
101SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2Kidney-5.110.000
102UPP2uridine phosphorylase 2Kidney-5.100.000
103LPPR1lipid phosphate phosphatase-related protein type 1Kidney-5.080.000
104CRYAAcrystallin, alpha AKidney-5.080.000
105C7complement component 7Kidney-5.070.002
106AKR1C2aldo-keto reductase family 1, member C2Kidney+5.070.014
107RALGAPA2Ral GTPase activating protein, alpha subunit 2 (catalytic)Kidney-5.050.000
108MYO3Bmyosin IIIBKidney-5.050.001
109TTC9tetratricopeptide repeat domain 9Kidney+5.030.000
110CWH43cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)Kidney-5.030.002
111ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideKidney-5.020.001
112CLNKcytokine-dependent hematopoietic cell linkerKidney+4.990.002
113TMEM61transmembrane protein 61Kidney-4.990.000
114SLC22A12solute carrier family 22 (organic anion/urate transporter), member 12Kidney-4.970.001
115ELF5E74-like factor 5 (ets domain transcription factor)Kidney-4.960.000
116MCOLN2mucolipin 2Kidney+4.940.001
117TOX3TOX high mobility group box family member 3Kidney-4.940.019
118FLJ22763uncharacterized LOC401081Kidney-4.940.006
119TCEAL2transcription elongation factor A (SII)-like 2Kidney-4.920.003
120LOC149703uncharacterized LOC149703Kidney-4.920.001
121TMEM45Btransmembrane protein 45BKidney-4.920.003
122EHFets homologous factorKidney-4.900.000
123ATP6V1C2ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2Kidney-4.900.000
124BMPR1Bbone morphogenetic protein receptor, type IBKidney-4.880.001
125SLC22A6solute carrier family 22 (organic anion transporter), member 6Kidney-4.870.011
126SCN2Asodium channel, voltage-gated, type II, alpha subunitKidney-4.870.001
127SLC7A8solute carrier family 7 (amino acid transporter light chain, L system), member 8Kidney-4.860.000
128KLRG2killer cell lectin-like receptor subfamily G, member 2Kidney-4.840.000
129GGT6gamma-glutamyltransferase 6Kidney-4.830.000
130ACPPacid phosphatase, prostateKidney-4.830.000
131ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2Kidney+4.810.000
132PROM2prominin 2Kidney-4.770.000
133PLCXD3phosphatidylinositol-specific phospholipase C, X domain containing 3Kidney-4.770.000
134CLDN16claudin 16Kidney-4.770.000
135AFMafaminKidney-4.760.001
136KCNE1potassium voltage-gated channel, Isk-related family, member 1Kidney-4.760.000
137KLK4kallikrein-related peptidase 4Kidney+4.750.003
138CLIC5chloride intracellular channel 5Kidney-4.730.000
139GPR110G protein-coupled receptor 110Kidney-4.720.000
140GATA3GATA binding protein 3Kidney-4.720.002
141ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney-4.710.000
142TFCP2L1transcription factor CP2-like 1Kidney-4.710.000
143GABRA2gamma-aminobutyric acid (GABA) A receptor, alpha 2Kidney-4.700.000
144CLDN19claudin 19Kidney-4.680.000
145PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AKidney-4.670.021
146CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Kidney+4.650.010
147ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptideKidney-4.650.000
148TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Kidney-4.630.000
149PTGER1prostaglandin E receptor 1 (subtype EP1), 42kDaKidney-4.620.000
150STAP1signal transducing adaptor family member 1Kidney-4.610.000
151LINC00982long intergenic non-protein coding RNA 982Kidney-4.600.000
152CHL1cell adhesion molecule L1-likeKidney-4.600.001
153IGFBP1insulin-like growth factor binding protein 1Kidney+4.590.040
154FOXI1forkhead box I1Kidney-4.590.000
155ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)Kidney-4.580.001
156SLC18A2solute carrier family 18 (vesicular monoamine transporter), member 2Kidney+4.580.007
157ALBalbuminKidney-4.570.000
158CRTAC1cartilage acidic protein 1Kidney+4.570.000
159L1CAML1 cell adhesion moleculeKidney-4.570.004
160PDGFRAplatelet-derived growth factor receptor, alpha polypeptideKidney-4.560.009
161CR1Lcomplement component (3b/4b) receptor 1-likeKidney+4.560.003
162FGF1fibroblast growth factor 1 (acidic)Kidney-4.560.000
163ADRB1adrenoceptor beta 1Kidney+4.550.000
164TMEM207transmembrane protein 207Kidney-4.550.000
165KLHL14kelch-like family member 14Kidney-4.530.001
166ANGPTL1angiopoietin-like 1Kidney-4.530.002
167CNTNAP5contactin associated protein-like 5Kidney+4.510.000
168SLC12A3solute carrier family 12 (sodium/chloride transporter), member 3Kidney-4.500.000
169GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Kidney+4.500.002
170NXPH2neurexophilin 2Kidney+4.480.022
171TMEM178Atransmembrane protein 178AKidney-4.480.000
172SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6DKidney-4.470.000
173TCF21transcription factor 21Kidney-4.450.002
174PDE1Aphosphodiesterase 1A, calmodulin-dependentKidney-4.440.000
175SOWAHAsosondowah ankyrin repeat domain family member AKidney-4.440.007
176HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)Kidney-4.430.036
177RBP4retinol binding protein 4, plasmaKidney-4.430.009
178ELAVL2ELAV like neuron-specific RNA binding protein 2Kidney+4.420.001
179CDAcytidine deaminaseKidney+4.410.005
180SOX8SRY (sex determining region Y)-box 8Kidney+4.350.012
181KRTAP9-3keratin associated protein 9-3Kidney+4.350.000
182LMF1lipase maturation factor 1Kidney+4.330.012
183DMRT2doublesex and mab-3 related transcription factor 2Kidney+4.310.000
184DOCK10dedicator of cytokinesis 10Kidney+4.270.000
185ABHD11abhydrolase domain containing 11Kidney+4.230.004
186ST8SIA5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5Kidney+4.170.002
187STAP1signal transducing adaptor family member 1Kidney+4.170.004
188SCDstearoyl-CoA desaturase (delta-9-desaturase)Kidney+4.160.000
189KRTAP5-8keratin associated protein 5-8Kidney+4.150.001
190C1orf53chromosome 1 open reading frame 53Kidney+4.110.009
191NRG2neuregulin 2Kidney+4.080.005
192TSPAN5tetraspanin 5Kidney+4.050.000
193SMOC1SPARC related modular calcium binding 1Kidney+4.010.002
194B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6Kidney+4.010.002
195LOC388820uncharacterized LOC388820Kidney+3.980.000
196VMA21VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)Kidney+3.980.000
197ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney+3.980.000
198LOC441052uncharacterized LOC441052Kidney+3.950.002
199TIMD4T-cell immunoglobulin and mucin domain containing 4Kidney+3.920.000
200APOC1apolipoprotein C-IKidney+3.920.001
201ANKRD29ankyrin repeat domain 29Kidney+3.910.000
202KLK15kallikrein-related peptidase 15Kidney+3.910.001
203TTKTTK protein kinaseKidney+3.890.003
204PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)Kidney+3.890.000
205DSG2desmoglein 2Kidney+3.870.000
206BIN2bridging integrator 2Kidney+3.820.006
207KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologKidney+3.820.000
208PDE1Cphosphodiesterase 1C, calmodulin-dependent 70kDaKidney+3.810.000
209SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3CKidney+3.800.000
210SLC29A4solute carrier family 29 (equilibrative nucleoside transporter), member 4Kidney+3.790.000
211FAM24Bfamily with sequence similarity 24, member BKidney+3.780.000
212SEC16BSEC16 homolog B (S. cerevisiae)Kidney+3.700.000
213PVT1Pvt1 oncogene (non-protein coding)Kidney+3.690.000
214TRDV3T cell receptor delta variable 3Kidney+3.640.000
215HTRA4HtrA serine peptidase 4Kidney+3.630.005
216TMEM45Atransmembrane protein 45AKidney+3.630.016
217SLC6A3solute carrier family 6 (neurotransmitter transporter), member 3Kidney+3.620.012
218CDKN2Acyclin-dependent kinase inhibitor 2AKidney+3.590.000
219RHOHras homolog family member HKidney+3.590.000
220PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)Kidney+3.590.003
221NETO2neuropilin (NRP) and tolloid (TLL)-like 2Kidney+3.570.001
222NEK2NIMA-related kinase 2Kidney+3.570.000
223P2RX7purinergic receptor P2X, ligand-gated ion channel, 7Kidney+3.570.000
224SIRPGsignal-regulatory protein gammaKidney+3.540.015
225ALOX5arachidonate 5-lipoxygenaseKidney+3.530.000
226TRDT cell receptor delta locusKidney+3.520.000
227TEN1TEN1 CST complex subunitKidney+3.500.000
228SLAMF8SLAM family member 8Kidney+3.500.001
229CCR5chemokine (C-C motif) receptor 5 (gene/pseudogene)Kidney+3.490.000
230BIN2bridging integrator 2Kidney+3.460.000
231TNFRSF4tumor necrosis factor receptor superfamily, member 4Kidney+3.440.001
232FCGR2CFc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)Kidney+3.420.000
233BRCA2breast cancer 2, early onsetKidney+3.390.000
234SLC17A4solute carrier family 17, member 4Kidney+3.380.019
235CXCL10chemokine (C-X-C motif) ligand 10Kidney+3.380.007
236PIK3R5phosphoinositide-3-kinase, regulatory subunit 5Kidney+3.370.000
237IGFBP3insulin-like growth factor binding protein 3Kidney+3.360.000
238VSIG1V-set and immunoglobulin domain containing 1Kidney+3.350.013
239ASPMasp (abnormal spindle) homolog, microcephaly associated (Drosophila)Kidney+3.330.004
240HIST1H3Hhistone cluster 1, H3hKidney+3.320.012
241GIT2G protein-coupled receptor kinase interacting ArfGAP 2Kidney+3.300.000
242CDKN3cyclin-dependent kinase inhibitor 3Kidney+3.290.000
243FANCIFanconi anemia, complementation group IKidney+3.270.000
244CDC25Ccell division cycle 25CKidney+3.260.010
245DUSP4dual specificity phosphatase 4Kidney+3.260.003
246CCL5chemokine (C-C motif) ligand 5Kidney+3.240.003
247DTLdenticleless E3 ubiquitin protein ligase homolog (Drosophila)Kidney+3.230.000
248CXCL11chemokine (C-X-C motif) ligand 11Kidney+3.210.010
249CST7cystatin F (leukocystatin)Kidney+3.200.004
250TNFSF13Btumor necrosis factor (ligand) superfamily, member 13bKidney+3.190.000
251RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)Kidney+3.190.002
252PARVGparvin, gammaKidney+3.180.000
253BUB1BUB1 mitotic checkpoint serine/threonine kinaseKidney+3.180.012
254ZNF395zinc finger protein 395Kidney+3.170.021
255MCM10minichromosome maintenance complex component 10Kidney+3.170.007
256TMEM44transmembrane protein 44Kidney+3.150.000
257LOXL2lysyl oxidase-like 2Kidney+3.140.003
258CD8ACD8a moleculeKidney+3.140.011
259XCL1chemokine (C motif) ligand 1Kidney+3.120.002
260VNN2vanin 2Kidney+3.110.005
261CENPKcentromere protein KKidney+3.110.001
262RRM2ribonucleotide reductase M2Kidney+3.090.006
263CHPF2chondroitin polymerizing factor 2Kidney+3.090.000
264CRTAMcytotoxic and regulatory T cell moleculeKidney+3.080.012
265SCDstearoyl-CoA desaturase (delta-9-desaturase)Kidney+3.080.001
266IL7Rinterleukin 7 receptorKidney+3.070.018
267LPCAT1lysophosphatidylcholine acyltransferase 1Kidney+3.050.000
268LCKlymphocyte-specific protein tyrosine kinaseKidney+3.050.000
269SAP30Sin3A-associated protein, 30kDaKidney+3.050.000
270PCSK6proprotein convertase subtilisin/kexin type 6Kidney+3.050.025
271TEAD4TEA domain family member 4Kidney+3.050.000
272SCARB1scavenger receptor class B, member 1Kidney+3.040.001
273CLEC12AC-type lectin domain family 12, member AKidney+3.030.003
274MYO9Bmyosin IXBKidney+3.010.001
275LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1Kidney+3.010.002
276PRR11proline rich 11Kidney+3.000.001

Search GEO for disease gene expression data for Renal Cell Carcinoma, Papillary.

Pathways for genes affiliated with Renal Cell Carcinoma, Papillary

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Pathways related to Renal Cell Carcinoma, Papillary according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Signaling Pathways in Glioblastoma36
9.4MITF, MET
29.4MITF, MET
38.6MET, PRCC, ASPSCR1, TFE3

Compounds for genes affiliated with Renal Cell Carcinoma, Papillary

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GO Terms for genes affiliated with Renal Cell Carcinoma, Papillary

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Cellular components related to Renal Cell Carcinoma, Papillary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056347.5MITF, AKR1C3, PRCC, ASPSCR1, TFE3

Biological processes related to Renal Cell Carcinoma, Papillary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glucose homeostasisGO:00425939.2MET, ASPSCR1
2regulation of osteoclast differentiationGO:00456709.2MITF, TFE3
3positive regulation of transcription from RNA polymerase II promoterGO:00459448.9MITF, MET, TFE3

Molecular functions related to Renal Cell Carcinoma, Papillary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein dimerization activityGO:00469839.3MITF, TFE3

Products for genes affiliated with Renal Cell Carcinoma, Papillary

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Sources for Renal Cell Carcinoma, Papillary

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet