CCRCC
MCID: RNL003
MIFTS: 53

Renal Clear Cell Carcinoma (CCRCC) malady

Genetic diseases, Nephrological diseases, Cancer diseases, Rare diseases categories
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Summaries for Renal Clear Cell Carcinoma

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Disease Ontology:8 A renal cell carcinoma that has material basis in cells that appear very pale or clear when examined under microscope.

MalaCards based summary: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to von hippel-lindau disease and cystadenoma. An important gene associated with Renal Clear Cell Carcinoma is HNF1A (HNF1 homeobox A), and among its related pathways is Glucose / Energy Metabolism. The compounds fumarate and biotin have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and tongue, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Renal Clear Cell Carcinoma

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Sources:
48Orphanet, 8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 26ICD10 via Orphanet
See all sources

Renal Clear Cell Carcinoma, Aliases & Descriptions:

Name: Renal Clear Cell Carcinoma 8 10 44
Conventional Renal Cell Carcinoma 8 62
Clear Cell Renal Cell Carcinoma 48 62
Clear Cell Carcinoma of Kidney 8 62
Clear Cell Kidney Carcinoma 8 62
Clear Cell Renal Cell Adenocarcinoma 48
 
Conventional Renal Cell Carcinoma 8
Clear Cell Renal Carcinoma 48
Adenocarcinoma, Clear Cell 62
Clear Cell Adenocarcinoma 48
Ccrcc 48


Classifications:



External Ids:

Disease Ontology8 DOID:4467
NCIt39 C4033
ICD10 via Orphanet26 C64

Related Diseases for Renal Clear Cell Carcinoma

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Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 151)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease31.0VHL, TMEM127, INHA
2cystadenoma31.0VHL, INHA
3polycythemia30.8VHL, EPOR
4paraganglioma30.6VHL, FH, TMEM127
5hemangioblastoma30.6VHL, EPOR, INHA
6ovarian cancer30.6INHA, AMACR, MUC3A, GSN
7wilms tumor30.5VHL, AMACR, INHA
8pheochromocytoma30.4INHA, EPOR, FH, VHL
9kidney cancer30.1AMACR, FH, VHL, HNF1A, CDH16
10adenoma30.0INHA, AMACR, MUC3A, VHL, HNF1A, GSN
11adenocarcinoma29.8INHA, AMACR, EPOR, MUC3A, FOLH1, VHL
12melanoma29.7INHA, AMACR, EPOR, CXCR3, FOLH1, GSN
13lung cancer29.5AMACR, MUC3A, CXCR3, VHL, HNF1A, GSN
14ovarian clear cell adenocarcinoma11.1
15vaginitis10.8
16endometriosis10.8
17thyroiditis10.7
18urethritis10.7
19papillary renal cell carcinoma10.6
20multilocular clear cell renal cell carcinoma10.6
21angiomyolipoma10.6
22clear cell papillary renal cell carcinoma10.6
23urethral diverticulum10.6
24cervicitis10.6
25obesity10.5
26cervical clear cell adenocarcinoma10.5
27hypoxia10.5
28nephrogenic adenoma10.5
29urethra clear cell adenocarcinoma10.5
30endometrial clear cell adenocarcinoma10.5
31prostatitis10.5
32clear cell adenocarcinoma of ovary10.5
33fumarate hydratase deficiency10.5FH
34hereditary conventional renal cell carcinoma10.4
35hemangioma10.4
36hepatitis10.4
37hepatitis a10.4
38chromosome 9p deletion10.4
39adenofibroma10.4
40bile duct clear cell adenocarcinoma10.4
41uterine ligament clear cell adenocarcinoma10.4
42fallopian tube clear cell adenocarcinoma10.4
43ampulla of vater clear cell adenocarcinoma10.4
44bladder tubulo-cystic clear cell adenocarcinoma10.4
45bladder papillary clear cell adenocarcinoma10.4
46bladder clear cell adenocarcinoma10.4
47peritonitis10.4
48pancreatitis10.4
49primary polycythemia10.4VHL, EPOR
50chromophobe renal cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:



Diseases related to renal clear cell carcinoma

Symptoms for Renal Clear Cell Carcinoma

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Drugs & Therapeutics for Renal Clear Cell Carcinoma

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Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

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Anatomical Context for Renal Clear Cell Carcinoma

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MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

32
Kidney, Thyroid, Tongue, Bone, Liver, Lung, Pancreas, Salivary gland, Breast, Tonsil, Endothelial, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

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MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7INHA, AMACR, EPOR, VHL, HNF1A
2MP:00053678.4DEFB1, AQP2, CXCR3, FH, VHL, HNF1A
3MP:00053977.7GSN, VHL, CXCR3, EPOR, AQP2, INHA
4MP:00053857.1INHA, EPOR, CXCR3, FOLH1, VHL, GSN
5MP:00107686.5DEFB1, INHA, AMACR, AQP2, EPOR, CXCR3
6MP:00053766.2GSN, INHA, AMACR, AQP2, EPOR, CXCR3

Publications for Renal Clear Cell Carcinoma

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Articles related to Renal Clear Cell Carcinoma:

(show top 50)    (show all 118)
idTitleAuthorsYear
1
Neoadjuvant sunitinib effectiveness in T4 renal clear cell carcinoma: a case report. (25050998)
2014
2
Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) project. (24454902)
2014
3
Identification of angiogenesis-related miRNAs in a population of patients with renal clear cell carcinoma. (25119741)
2014
4
The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma. (25388155)
2014
5
Bilateral synchronous multifocal renal clear-cell carcinoma. (23627203)
2013
6
Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. (22534085)
2013
7
Multiphasic contrast-enhanced MRI: single-slice versus volumetric quantification of tumor enhancement for the assessment of renal clear-cell carcinoma fuhrman grade. (23152173)
2013
8
Osteomalacia-inducing renal clear cell carcinoma uncovered by 99mTc-Hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC) scintigraphy. (24089059)
2013
9
Hypoxia-inducible factor 1I+ mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma. (23611775)
2013
10
Lower mRNA and protein expression levels of LC3 and Beclin1, markers of autophagy, were correlated with progression of renal clear cell carcinoma. (24186908)
2013
11
Fine-needle aspiration cytology of renal clear cell carcinoma metastatic to the thyroid gland. (23729320)
2013
12
Subtotal distal pancreatectomy for metachronous metastatic renal clear cell carcinoma. (23368657)
2012
13
Expression and prognostic significance of Src family members in renal clear cell carcinoma. (22814579)
2012
14
Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (21544807)
2012
15
Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma. (23467480)
2011
16
Stage pT3a of renal clear cell carcinoma: do tumors with sinus fat involvement behave the same as those with perinephric fat involvement? (21655644)
2011
17
Genetic heterogeneity and chromatin modifiers in renal clear cell carcinoma. (20528227)
2010
18
Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? (21102591)
2010
19
The expression and clinical significance of TGF-beta1 and MMP2 in human renal clear cell carcinoma. (19223381)
2010
20
A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells. (19885558)
2009
21
Microarray analysis of microRNA expression in renal clear cell carcinoma. (19443172)
2009
22
Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma. (19493467)
2009
23
Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. (18359287)
2008
24
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. (18006011)
2008
25
A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma. (18581596)
2008
26
Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (17973242)
2008
27
High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. (17922474)
2007
28
Metastatic renal clear cell carcinoma in the parotid gland: a study of immunohistochemical profile and cell adhesion molecules (CAMs) expression in two cases. (17607380)
2007
29
Transient massive peripheral blood blastosis in patient with renal clear-cell carcinoma after treatment with high-dose recombinant interleuklin-2. (17329199)
2007
30
Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. (15912297)
2005
31
Diffuse expression of MUC 1 in metastases of renal clear cell carcinoma as a possible therapeutic target for renal cancer. (16178902)
2005
32
Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. (15968199)
2005
33
Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma. (14767340)
2004
34
Somatic mutations of VHL gene and HIF-1alpha expression in primary renal clear cell carcinomas]. (15062033)
2004
35
Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. (15505308)
2004
36
Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. (15126876)
2004
37
Intradural spinal metastasis of renal clear cell carcinoma causing cauda equina syndrome. (15254809)
2004
38
The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma. (15180922)
2004
39
Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. (15145526)
2004
40
Metastatic renal clear cell carcinoma mimicking stage IV lung cancer. (14620276)
2003
41
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (12576453)
2003
42
Fatty metastatic lesions in 2 patients with renal clear-cell carcinoma. (14600452)
2003
43
Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. (12434420)
2002
44
Type I 5'-iodothyronine deiodinase activity and mRNA are remarkably reduced in renal clear cell carcinoma. (11383912)
2001
45
Thyroid metastases from renal clear cell carcinoma: a cyto-histological study of two cases. (11753829)
2001
46
Correlation of CD44S expression in renal clear cell carcinomas with subsequent tumor progression or recurrence. (10590373)
1999
47
Metastatic renal clear cell carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology. (1878525)
1991
48
Metastatic renal clear cell carcinoma of the jaws. Two cases illustrating clinical and pathological diagnostic problems. (2135656)
1990
49
Late results of surgical treatment of renal clear-cell carcinoma. (3721763)
1986
50
ELECTRON MICROSCOPIC OBSERVATIONS ON SPECIALIZATIONS OF THE CELL SURFACE IN RENAL CLEAR CELL CARCINOMA. (14279879)
1965

Variations for Renal Clear Cell Carcinoma

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Clinvar genetic disease variations for Renal Clear Cell Carcinoma:

6
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenicGRCh37Chr 12, 121432125: 121432125

Expression for genes affiliated with Renal Clear Cell Carcinoma

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Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

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Pathways related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2HNF1A, FH, AQP2, AMACR

Compounds for genes affiliated with Renal Clear Cell Carcinoma

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Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1fumarate44 1110.8VHL, FH, AMACR
2biotin44 24 1111.7AQP2, AMACR, INHA
3streptavidin449.5FOLH1, EPOR, AMACR
4cobalt44 2410.5VHL, FOLH1
5proline449.5EPOR, FH, VHL, HNF1A
6aldose449.5GSN, AQP2
7cholesterol44 28 24 1112.3AMACR, MUC3A, CXCR3, HNF1A
8creatinine449.2HNF1A, FH, CXCR3, AQP2
9dexamethasone44 50 28 1112.1HNF1A, CXCR3, AQP2, AMACR, DEFB1
10methionine449.0GSN, AQP2, AMACR
11thymidine44 2410.0EPOR, CXCR3, FOLH1, HNF1A
12progesterone44 28 61 24 1112.9INHA, AMACR, AQP2, MUC3A, CXCR3
13vegf448.8EPOR, CXCR3, FOLH1, VHL
14nitric oxide44 24 1110.7AQP2, EPOR, CXCR3, VHL
15lipid448.6AMACR, AQP2, EPOR, HNF1A, GSN
16fatty acid448.6INHA, AMACR, FH, HNF1A, GSN
17phosphatidylinositol448.5EPOR, CXCR3, VHL, GSN
18testosterone44 61 24 1111.5GSN, FOLH1, AMACR, INHA
19estrogen448.4INHA, AMACR, EPOR, MUC3A, CXCR3, VHL
20oxygen44 249.3EPOR, CXCR3, FH, VHL, GSN
21glutamate448.3GSN, FOLH1, EPOR, AMACR
22cysteine448.3GSN, FOLH1, EPOR, AQP2, AMACR
23alanine448.2INHA, AQP2, EPOR, FOLH1, GSN
24oligonucleotide448.1INHA, AMACR, EPOR, MUC3A, VHL, HNF1A
25steroid447.8INHA, AQP2, EPOR, MUC3A, CXCR3, HNF1A
26serine447.8AQP2, EPOR, CXCR3, FOLH1, VHL, GSN
27glucose447.8GSN, DEFB1, AMACR, AQP2, EPOR, FH
28tyrosine447.4INHA, AMACR, EPOR, CXCR3, FH, VHL
29calcium44 50 24 1110.4AMACR, AQP2, EPOR, MUC3A, CXCR3, VHL

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

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Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.8GSN, HNF1A, AQP2
2extracellular regionGO:0055768.3GSN, MUC3A, EPOR, INHA, DEFB1

Products for genes affiliated with Renal Clear Cell Carcinoma

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  • Antibodies
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Sources for Renal Clear Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet