CCRCC
MCID: RNL003
MIFTS: 52

Renal Clear Cell Carcinoma (CCRCC) malady

Genetic diseases, Nephrological diseases, Cancer diseases, Rare diseases categories

Summaries for Renal Clear Cell Carcinoma

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9Disease Ontology, 34MalaCards
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Disease Ontology:9 A renal cell carcinoma that is the most common type of renal cell carcinoma. the cancerous cells appear very pale or clear when examined under microscope. this cancer can be effectively treated with surgery if the tumor is confined to the kidney.

MalaCards: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to von hippel-lindau disease and adenoma. An important gene associated with Renal Clear Cell Carcinoma is MITF (microphthalmia-associated transcription factor), and among its related pathways is Glucose / Energy Metabolism. The compounds fumarate and biotin have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and tongue, and related mouse phenotypes are renal/urinary system and hematopoietic system.

Aliases & Classifications for Renal Clear Cell Carcinoma

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50Orphanet, 9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:



Aliases & Descriptions:

renal clear cell carcinoma 9 11 46
conventional renal cell carcinoma 9 63
clear cell renal cell adenocarcinoma 50
conventional renal cell carcinoma 9
clear cell renal cell carcinoma 50
clear cell carcinoma of kidney 9
clear cell renal carcinoma 50
adenocarcinoma, clear cell 63
clear cell adenocarcinoma 50
ccrcc 50


External Ids:

Disease Ontology9 DOID:4467
NCIt41 C4033
SNOMED-CT via Orphanet60 254915003
ICD10 via Orphanet27 C64

Related Diseases for Renal Clear Cell Carcinoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1von hippel-lindau disease30.9INHA, TMEM127, VHL
2adenoma30.7INHA, AMACR, MUC3A, VHL, GSN
3ovarian cancer30.7GSN, MUC3A, AMACR, INHA
4cystadenoma30.5VHL, INHA
5adrenal adenoma30.5VHL, INHA
6paraganglioma30.5VHL, FH, TMEM127
7polycythemia30.4VHL, EPOR
8hemangioblastoma30.4VHL, EPOR, INHA
9adenocarcinoma30.3INHA, AMACR, EPOR, MUC3A, FOLH1, VHL
10kidney cancer30.3AMACR, FH, VHL, CDH16
11pheochromocytoma30.3INHA, EPOR, FH, VHL
12wilms tumor30.3INHA, AMACR, VHL
13lung cancer30.2GSN, VHL, CXCR3, MUC3A, AMACR
14melanoma30.1INHA, AMACR, EPOR, CXCR3, FOLH1, MITF
15ovarian clear cell adenocarcinoma11.1
16vaginitis10.9
17endometriosis10.8
18thyroiditis10.7
19urethritis10.7
20urethral diverticulum10.6
21cervicitis10.6
22multilocular clear cell renal cell carcinoma10.5
23papillary renal cell carcinoma10.5
24angiomyolipoma10.5
25obesity10.5
26clear cell papillary renal cell carcinoma10.5
27cervical clear cell adenocarcinoma10.5
28hypoxia10.5
29nephrogenic adenoma10.5
30endometrial clear cell adenocarcinoma10.5
31hereditary conventional renal cell carcinoma10.4
32hepatitis a10.4
33hemangioma10.4
34hepatitis10.4
35urethra clear cell adenocarcinoma10.4
36adenofibroma10.4
37prostatitis10.4
38clear cell adenocarcinoma of ovary10.4
39bile duct clear cell adenocarcinoma10.4
40bladder tubulo-cystic clear cell adenocarcinoma10.4
41bladder papillary clear cell adenocarcinoma10.4
42uterine ligament clear cell adenocarcinoma10.4
43fallopian tube clear cell adenocarcinoma10.4
44ampulla of vater clear cell adenocarcinoma10.4
45bladder clear cell adenocarcinoma10.4
46peritonitis10.4
47chromophobe renal cell carcinoma10.3
48clear cell renal cell carcinoma10.3
49collecting duct carcinoma10.3
50phaeochromocytoma10.3

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:



Diseases related to renal clear cell carcinoma

Symptoms for Renal Clear Cell Carcinoma

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Drugs & Therapeutics for Renal Clear Cell Carcinoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Renal Clear Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Search CenterWatch for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

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Anatomical Context for Renal Clear Cell Carcinoma

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34MalaCards
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MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

34
Kidney, Thyroid, Tongue, Endothelial, Breast, Salivary gland, Bone, Pancreas, Lung, Liver, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3DEFB1, AQP2, CXCR3, FH, VHL
2MP:00053977.4INHA, AQP2, EPOR, CXCR3, MITF, VHL
3MP:00053857.4GSN, VHL, FOLH1, CXCR3, EPOR, INHA
4MP:00053877.4DEFB1, INHA, EPOR, CXCR3, MITF, VHL
5MP:00107686.5DEFB1, INHA, AMACR, AQP2, EPOR, CXCR3
6MP:00053766.2GSN, INHA, AMACR, AQP2, EPOR, CXCR3

Publications for Renal Clear Cell Carcinoma

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53PubMed
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Articles related to Renal Clear Cell Carcinoma:

(show top 50)    (show all 105)
idTitleAuthorsYear
1
Bilateral synchronous multifocal renal clear-cell carcinoma. (23627203)
2013
2
Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. (22534085)
2013
3
Multiphasic contrast-enhanced MRI: single-slice versus volumetric quantification of tumor enhancement for the assessment of renal clear-cell carcinoma fuhrman grade. (23152173)
2013
4
Osteomalacia-inducing renal clear cell carcinoma uncovered by 99mTc-Hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC) scintigraphy. (24089059)
2013
5
Hypoxia-inducible factor 1I+ mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma. (23611775)
2013
6
Lower mRNA and protein expression levels of LC3 and Beclin1, markers of autophagy, were correlated with progression of renal clear cell carcinoma. (24186908)
2013
7
Fine-needle aspiration cytology of renal clear cell carcinoma metastatic to the thyroid gland. (23729320)
2013
8
Subtotal distal pancreatectomy for metachronous metastatic renal clear cell carcinoma. (23368657)
2012
9
Expression and prognostic significance of Src family members in renal clear cell carcinoma. (22814579)
2012
10
Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (21544807)
2012
11
LncRNAs expression signatures of renal clear cell carcinoma revealed by microarray. (22879955)
2012
12
Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma. (23467480)
2011
13
Stage pT3a of renal clear cell carcinoma: do tumors with sinus fat involvement behave the same as those with perinephric fat involvement? (21655644)
2011
14
Genetic heterogeneity and chromatin modifiers in renal clear cell carcinoma. (20528227)
2010
15
Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? (21102591)
2010
16
The expression and clinical significance of TGF-beta1 and MMP2 in human renal clear cell carcinoma. (19223381)
2010
17
Prognostic factors and survival of renal clear cell carcinoma patients with bone metastases. (19639393)
2010
18
A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells. (19885558)
2009
19
Microarray analysis of microRNA expression in renal clear cell carcinoma. (19443172)
2009
20
Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma. (19493467)
2009
21
Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. (18359287)
2008
22
Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. (18006011)
2008
23
A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma. (18581596)
2008
24
Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (17973242)
2008
25
Computational pathology analysis of tissue microarrays predicts survival of renal clear cell carcinoma patients. (18982583)
2008
26
Solitary intrathyroidal metastasis of renal clear cell carcinoma in a toxic substernal multinodular goiter. (19014412)
2008
27
High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. (17922474)
2007
28
Metastatic renal clear cell carcinoma in the parotid gland: a study of immunohistochemical profile and cell adhesion molecules (CAMs) expression in two cases. (17607380)
2007
29
Transient massive peripheral blood blastosis in patient with renal clear-cell carcinoma after treatment with high-dose recombinant interleuklin-2. (17329199)
2007
30
Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. (15912297)
2005
31
Diffuse expression of MUC 1 in metastases of renal clear cell carcinoma as a possible therapeutic target for renal cancer. (16178902)
2005
32
Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. (15968199)
2005
33
Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma. (14767340)
2004
34
Somatic mutations of VHL gene and HIF-1alpha expression in primary renal clear cell carcinomas]. (15062033)
2004
35
Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. (15505308)
2004
36
Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. (15126876)
2004
37
Intradural spinal metastasis of renal clear cell carcinoma causing cauda equina syndrome. (15254809)
2004
38
The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma. (15180922)
2004
39
Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. (15145526)
2004
40
Metastatic renal clear cell carcinoma mimicking stage IV lung cancer. (14620276)
2003
41
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (12576453)
2003
42
Fatty metastatic lesions in 2 patients with renal clear-cell carcinoma. (14600452)
2003
43
Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. (12670587)
2003
44
Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. (12434420)
2002
45
Thyroid metastases from renal clear cell carcinoma: a cyto-histological study of two cases. (11753829)
2001
46
Correlation of CD44S expression in renal clear cell carcinomas with subsequent tumor progression or recurrence. (10590373)
1999
47
Renal clear cell carcinoma appearing as a left neck mass. (8870369)
1996
48
Metastatic renal clear cell carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology. (1878525)
1991
49
Metastatic renal clear cell carcinoma of the jaws. Two cases illustrating clinical and pathological diagnostic problems. (2135656)
1990
50
Late results of surgical treatment of renal clear-cell carcinoma. (3721763)
1986

Variations for Renal Clear Cell Carcinoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Renal Clear Cell Carcinoma:

1
id Gene Name Type Significance SNP ID Assembly Location
1HNF1ANM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)duplicationPathogenic/card/renal_clear_cell_carcinomaGRCh37Chr 12, 121432125: 121432125
2HNF1ANM_000545.5(HNF1A): c.92G> A (p.Gly31Asp)single nucleotide variantPathogenicrs137853247GRCh37Chr 12, 121416663: 121416663

Expression for genes affiliated with Renal Clear Cell Carcinoma

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

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51PathCards, 5Cell Signaling Technology
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Pathways related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4FH, AQP2, AMACR

Compounds for genes affiliated with Renal Clear Cell Carcinoma

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46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 28)
idCompoundScoreTop Affiliating Genes
1fumarate46 1210.8VHL, FH, AMACR
2biotin46 25 1211.6INHA, AMACR, AQP2
3tacrolimus46 52 1211.6MITF, CXCR3, EPOR
4streptavidin469.5AMACR, EPOR, FOLH1
5aldose469.5GSN, AQP2
6paraffin469.4MITF, EPOR, AMACR, INHA
7cobalt46 2510.3VHL, FOLH1
8dexamethasone46 52 30 1212.2DEFB1, AMACR, AQP2, CXCR3
9arginine469.1AQP2, EPOR, CXCR3, MITF
10nitric oxide46 25 1211.0VHL, CXCR3, EPOR, AQP2
11progesterone46 30 62 25 1212.9INHA, AMACR, AQP2, MUC3A, CXCR3
12methionine468.9AMACR, AQP2, GSN
13vegf468.8EPOR, CXCR3, FOLH1, VHL
14fatty acid468.7GSN, FH, AMACR, INHA
15lipid468.6AMACR, AQP2, EPOR, MITF, GSN
16estrogen468.6INHA, AMACR, EPOR, MUC3A, CXCR3, VHL
17phosphatidylinositol468.5GSN, VHL, CXCR3, EPOR
18testosterone46 62 25 1211.5GSN, FOLH1, AMACR, INHA
19glutamate468.4GSN, MITF, FOLH1, EPOR, AMACR
20cysteine468.2AMACR, AQP2, EPOR, FOLH1, GSN
21alanine468.2INHA, AQP2, EPOR, FOLH1, GSN
22oxygen46 259.2EPOR, CXCR3, MITF, FH, VHL, GSN
23oligonucleotide468.1GSN, INHA, AMACR, EPOR, MUC3A, MITF
24steroid468.1INHA, AQP2, EPOR, MUC3A, CXCR3, GSN
25glucose468.0DEFB1, AMACR, AQP2, EPOR, FH, VHL
26serine467.8AQP2, EPOR, CXCR3, FOLH1, VHL, GSN
27tyrosine467.4INHA, AMACR, EPOR, CXCR3, MITF, FH
28calcium46 52 25 1210.2AMACR, AQP2, EPOR, MUC3A, CXCR3, MITF

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

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17Gene Ontology
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Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:0432348.8GSN, MITF, AQP2
2extracellular regionGO:0055768.3GSN, MUC3A, EPOR, INHA, DEFB1

Products for genes affiliated with Renal Clear Cell Carcinoma

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Sources for Renal Clear Cell Carcinoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet