CCRCC
MCID: RNL003
MIFTS: 58

Renal Clear Cell Carcinoma (CCRCC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Clear Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A renal cell carcinoma that is the most common type of renal cell carcinoma. the cancerous cells appear very pale or clear when examined under microscope. this cancer can be effectively treated with surgery if the tumor is confined to the kidney.

MalaCards: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to colon adenocarcinoma and von hippel-lindau disease. An important gene associated with Renal Clear Cell Carcinoma is MITF (microphthalmia-associated transcription factor), and among its related pathways are Hypoxic and oxygen homeostasis regulation of HIF-1-alpha and Cellular response to hypoxia. The compounds estrogen and fumarate have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and thyroid, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Renal Clear Cell Carcinoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 34MeSH, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal clear cell carcinoma 8 10 44
conventional renal cell carcinoma 8 60
clear cell renal cell adenocarcinoma 48
conventional renal cell carcinoma 8
clear cell renal cell carcinoma 48
clear cell carcinoma of kidney 8
clear cell renal carcinoma 48
adenocarcinoma, clear cell 60
clear cell adenocarcinoma 48
ccrcc 48


External Ids:

Disease Ontology8 DOID:4467
NCIt39 C4033
SNOMED-CT via Orphanet57 254915003
ICD10 via Orphanet26 C64

Related Diseases for Renal Clear Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma Familial Renal Cell Carcinoma
Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1colon adenocarcinoma30.8POLR2L
2von hippel-lindau disease30.8VHL, INHA, RASSF1, TCEB2
3angiomyolipoma30.7MITF, S100A1
4adenoma30.7VHL, AMACR, S100A1, MUC3A, INHA, RASSF1
5nephrogenic adenoma30.6AMACR, S100A1, KRT7
6ovarian cancer30.6VHL, INHA, CXCR3, RASSF1, KRT7
7hepatitis30.6AMACR
8adenocarcinoma30.4VHL, AMACR, CA9, MUC3A, EPOR, CLDN7
9cystadenoma30.3VHL, INHA, KRT7
10meningioma30.3S100A1, INHA
11paraganglioma30.3FH, S100A1, VHL
12chordoma30.3S100A1, INHA, KRT7
13bladder carcinoma30.3FH, RASSF1, GSN
14cystic kidney30.3FH, VHL
15melanoma30.3AMACR, CA9, S100A1, MITF, EPOR, INHA
16lung adenocarcinoma30.3AMACR, MUC3A, RASSF1, KRT7
17squamous cell carcinoma30.3VHL, AMACR, CA9, S100A1, DEFB1, EPOR
18hemangioblastoma30.2INHA, EPOR, VHL
19pheochromocytoma30.2VHL, FH, EPOR, INHA
20lung cancer30.2VHL, AMACR, CA9, S100A1, MUC3A, CXCR3
21papillary carcinoma30.2AMACR, S100A1, KRT7
22renal oncocytoma30.2PVALB, S100A1, CDH16, KRT7
23kidney cancer30.2KRT7, TCEB2, CDH16, FH, CA9, AMACR
24retinoblastoma30.2PVALB, VHL, POLR2L, MITF, RASSF1
25endometrial carcinoma30.1CA9, INHA, RASSF1, KRT7
26gastric adenocarcinoma30.1EPOR, CLDN7, KRT7
27renal cell carcinoma11.2
28ovarian clear cell adenocarcinoma11.1
29urethra clear cell adenocarcinoma10.8
30ovary adenocarcinoma10.8
31vaginitis10.8
32urethra adenocarcinoma10.8
33bladder clear cell adenocarcinoma10.8
34endometriosis10.8
35bladder adenocarcinoma10.7
36thyroiditis10.7
37multilocular clear cell renal cell carcinoma10.7
38endometrial clear cell adenocarcinoma10.7
39urethritis10.6
40endometrial adenocarcinoma10.6
41adrenal carcinoma10.6
42cervical clear cell adenocarcinoma10.6
43urethral diverticulum10.5
44cervical adenocarcinoma10.5
45cervicitis10.5
46obesity10.5
47clear cell adenoma10.5
48fallopian tube clear cell adenocarcinoma10.4
49hereditary conventional renal cell carcinoma10.4
50small cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:



Diseases related to renal clear cell carcinoma

Clinical Features for Renal Clear Cell Carcinoma

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Drugs & Therapeutics for Renal Clear Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renal Clear Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Search CenterWatch for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

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Anatomical Context for Renal Clear Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

32
Kidney, Endothelial, Thyroid, T cells, Bone, Breast, Tongue, Lung, Pancreas, Lymph node, Brain, Prostate, Ovary, Colon, Adrenal gland, Salivary gland, Smooth muscle, Liver, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.3VHL, S100A1, MITF, EPOR, INHA, CXCR3
2MP:000537610.3AMACR, FH, MITF, CXCR3, AQP2, GSN
3MP:001076810.3GSN, VHL, AMACR, CA9, FH, DEFB1
4MP:000536710.1VHL, FH, DEFB1, CLDN7, CXCR3, KRT7

Publications for Renal Clear Cell Carcinoma

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Sources:
50PubMed
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Articles related to Renal Clear Cell Carcinoma:

(show top 50)    (show all 788)
idTitleAuthorsYear
1
Re: Carbonic Anhydrase IX (CAIX) is Not an Independent Predictor of Outcome in Patients with Clear Cell Renal Cell Carcinoma (ccRCC) after Long-Term Follow-up. (24331469)
2014
2
Lymphovascular invasion in clear cell renal cell carcinoma-Association with disease-free and cancer-specific survival. (23428539)
2014
3
Resistance to tyrosine kinase inhibitors in clear cell renal cell carcinoma: From the patient's bed to molecular mechanisms. (24135488)
2014
4
Gene expression profiling of clear cell papillary renal cell carcinoma: comparison with clear cell renal cell carcinoma and papillary renal cell carcinoma. (23887297)
2013
5
A clear picture of renal cell carcinoma. (23892664)
2013
6
Renal cell carcinoma with areas mimicking renal angiomyoadenomatous tumor/clear cell papillary renal cell carcinoma. (23434146)
2013
7
Nuclear expression of Smad proteins and its prognostic significance in clear cell renal cell carcinoma. (23668999)
2013
8
Positive feedback loop and synergistic effects between hypoxia-inducible factor-2I+ and stearoyl-CoA desaturase-1 promote tumorigenesis in clear cell renal cell carcinoma. (23331615)
2013
9
Update on selected renal cell tumors with clear cell features. With emphasis on multilocular cystic clear cell renal cell carcinoma. (23893851)
2013
10
Prognostic implication of TIM-3 in clear cell renal cell carcinoma. (24050547)
2013
11
Integrated molecular analysis of clear-cell renal cell carcinoma. (23797736)
2013
12
CMTM3 is frequently reduced in clear cell renal cell carcinoma and exhibits tumor suppressor activities. (23907292)
2013
13
Cytoreductive nephrectomy in patients with metastatic non-clear cell renal cell carcinoma. (24053727)
2013
14
Prognostic Impact of Intratumoral C-Reactive Protein Expression in Patients with Clear Cell Renal Cell Carcinoma. (24356040)
2013
15
Comprehensive molecular characterization of clear cell renal cell carcinoma. (23792563)
2013
16
Erythrocyte sedimentation rate and anaemia are independent predictors of survival in patients with clear cell renal cell carcinoma. (23299540)
2013
17
Expression of parafibromin in clear cell papillary renal cell carcinoma. (23060304)
2013
18
TGF-I^-activated kinase-1: a potential prognostic marker for clear cell renal cell carcinoma. (23534745)
2013
19
NOTCH1 functions as an oncogene by regulating the PTEN/PI3K/AKT pathway in clear cell renal cell carcinoma. (21993533)
2013
20
Predictive factors for late recurrence in patients with stage T1 clear cell renal cell carcinoma: a multiinstitutional study. (23017336)
2013
21
Fibronectin 1 protein expression in clear cell renal cell carcinoma. (22740994)
2012
22
Re: Kidney size and cancer-specific survival for patients undergoing nephrectomy for pT1 clear cell renal cell carcinoma. (23059210)
2012
23
Clear cell papillary renal cell carcinoma with characteristic morphology and immunohistochemical staining pattern. (22931041)
2012
24
CD146 gene expression in clear cell renal cell carcinoma: a potential marker for prediction of early recurrence after nephrectomy. (22826148)
2012
25
Methylation pattern of the putative tumor-suppressor gene LRRC3B promoter in clear cell renal cell carcinomas. (22101383)
2012
26
Role of inflammatory related gene expression in clear cell renal cell carcinoma development and clinical outcomes. (21944129)
2011
27
Clear cell renal cell carcinoma with focal renal angiomyoadenomatous tumor-like area. (20952290)
2011
28
Misdiagnosis of clear cell renal cell carcinoma. (21587224)
2011
29
Negative impact of bone metastasis on outcome in clear-cell renal cell carcinoma treated with sunitinib. (20937648)
2011
30
Editorial comment on: External validation of the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score for clear-cell renal cell carcinoma in a single European centre applying routine pathology. (19062156)
2010
31
Microarray analysis of microRNA expression in renal clear cell carcinoma. (19443172)
2009
32
Methylation of promoter region of RASSF1A gene and frequencies of allelic imbalances in chromosome 3 critical regions are correlated with progression of clear cell renal cell carcinoma]. (19548529)
2009
33
Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma. (19124809)
2009
34
Sporadic clear cell renal cell carcinoma with diffuse cytokeratin 7 immunoreactivity. (18604734)
2008
35
Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (17973242)
2008
36
Carbonic anhydrase IX expression in clear cell renal cell carcinoma: an immunohistochemical study comparing 2 antibodies. (18300814)
2008
37
Prognostic significance of serum hepatocyte growth factor in clear cell renal cell carcinoma: comparison with serum vascular endothelial growth factor. (18319552)
2008
38
Loss of chromosome 9p is an independent prognostic factor in patients with clear cell renal cell carcinoma. (17906617)
2008
39
Safety and tolerability of sorafenib in clear-cell renal cell carcinoma: a Phase III overview. (17892420)
2007
40
Melanotic clear cell epithelioid angiomyolipoma: a rare entity and a mimic of clear cell renal carcinoma. (17257141)
2007
41
Anti-CD26 monoclonal antibody-mediated G1-S arrest of human renal clear cell carcinoma Caki-2 is associated with retinoblastoma substrate dephosphorylation, cyclin-dependent kinase 2 reduction, p27(kip1) enhancement, and disruption of binding to the extracellular matrix. (16740772)
2006
42
Genome-wide gene expression profiles of clear cell renal cell carcinoma: identification of molecular targets for treatment of renal cell carcinoma. (16964377)
2006
43
Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. (15930277)
2005
44
Impaired expression of the cell cycle regulator BTG2 is common in clear cell renal cell carcinoma. (14996721)
2004
45
Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas. (14991587)
2004
46
A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma. (12819395)
2003
47
Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney. (12378530)
2002
48
Pigmented renal clear cell carcinoma with melanocytic differentiation. (11230713)
2001
49
VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation. (10766184)
2000
50
Nuclear processes with N and C nuclei of emulsion induced by deuterons present in human renal clear-cell carcinoma. (5719293)
1968

Genetic Variations for Renal Clear Cell Carcinoma

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Expression for genes affiliated with Renal Clear Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

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Sources:
37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Renal Clear Cell Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8PVALB
2fumarate44 1111.8FH, AMACR, VHL
3hematoxylin4410.7AMACR, S100A1, INHA, KRT7
4biotin44 11 2412.7AQP2, INHA, S100A1, AMACR
5streptavidin4410.7KRT7, EPOR, AMACR
65-aza-2deoxycytidine4410.7VHL, CA9, POLR2L, RASSF1, KRT7
7methionine4410.7PVALB, AMACR, RASSF1, AQP2, GSN
8glucose4410.7AMACR, CA9, DEFB1, TCEB2, KRT7, AQP2
9oligonucleotide4410.7VHL, AMACR, POLR2L, MITF, MUC3A, EPOR
10paraffin4410.7PVALB, AMACR, CA9, S100A1, MITF, EPOR
11progesterone44 59 28 11 2414.7AMACR, CA9, S100A1, MUC3A, INHA, CXCR3
12oxygen44 2411.7VHL, CA9, FH, MITF, EPOR, CXCR3
13steroid4410.7MUC3A, EPOR, INHA, CXCR3, AQP2, GSN
14vegf4410.7VHL, CA9, POLR2L, EPOR, CXCR3, TCEB2
15proline4410.7VHL, CA9, FH, POLR2L, EPOR
16calcium44 49 11 2413.6S100A1, CA9, AMACR, VHL, PVALB, MITF
17iron44 2411.6PVALB, VHL, S100A1, EPOR, KRT7
18tyrosine4410.6S100A1, CA9, AMACR, VHL, PVALB, FH
19hydrogen44 2411.6CA9, S100A1, FH, INHA, AQP2
20retinoic acid44 2411.6AMACR, S100A1, DEFB1, POLR2L, RASSF1, KRT7
21serine4410.6PVALB, VHL, POLR2L, EPOR, CXCR3, RASSF1
22pimonidazole4410.6EPOR, CA9
23chloride4410.6PVALB, AMACR, CA9, AQP2
24arginine4410.6POLR2L, MITF, EPOR, CXCR3, KRT7, AQP2
25nitric oxide44 11 2412.6PVALB, VHL, S100A1, EPOR, CXCR3, AQP2
26silver4410.6PVALB, S100A1, MITF
27nad+4410.5INHA, FH, PVALB
28cysteine4410.5AMACR, S100A1, POLR2L, EPOR, AQP2, GSN
29glycogen44 2411.4VHL, S100A1, KRT7, GSN
30testosterone44 59 11 2413.4AMACR, POLR2L, INHA, KRT7, GSN
31azathioprine44 49 2 1113.3GSN, RASSF1, POLR2L
32mucicarmine4410.1KRT7, S100A1

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

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16Gene Ontology
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Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:04323410.4GSN, AQP2, MITF, S100A1

Biological processes related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145610.4TCEB2, CA9, VHL
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.1TCEB2, CA9, VHL

Products for genes affiliated with Renal Clear Cell Carcinoma

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Sources for Renal Clear Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet