CCRCC
MCID: RNL003
MIFTS: 58

Renal Clear Cell Carcinoma (CCRCC) malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Clear Cell Carcinoma

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8Disease Ontology, 32MalaCards
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Disease Ontology:8 A renal cell carcinoma that is the most common type of renal cell carcinoma. the cancerous cells appear very pale or clear when examined under microscope. this cancer can be effectively treated with surgery if the tumor is confined to the kidney.

MalaCards: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to colon adenocarcinoma and von hippel-lindau disease. An important gene associated with Renal Clear Cell Carcinoma is MITF (microphthalmia-associated transcription factor), and among its related pathways are Hypoxic and oxygen homeostasis regulation of HIF-1-alpha and Cellular response to hypoxia. The compounds estrogen and fumarate have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and thyroid, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Renal Clear Cell Carcinoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 48Orphanet, 34MeSH, 39NCIt, 56SNOMED-CT, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal clear cell carcinoma 8 10 44
conventional renal cell carcinoma 8 60
clear cell renal cell adenocarcinoma 48
conventional renal cell carcinoma 8
clear cell renal cell carcinoma 48
clear cell carcinoma of kidney 8
clear cell renal carcinoma 48
adenocarcinoma, clear cell 60
clear cell adenocarcinoma 48
ccrcc 48


External Ids:

Disease Ontology8 DOID:4467
NCIt39 C4033
SNOMED-CT via Orphanet57 254915003
ICD10 via Orphanet26 C64

Related Diseases for Renal Clear Cell Carcinoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma Familial Renal Cell Carcinoma
Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 199)
idRelated DiseaseScoreTop Affiliating Genes
1colon adenocarcinoma30.8POLR2L
2von hippel-lindau disease30.8VHL, INHA, RASSF1, TCEB2
3angiomyolipoma30.7MITF, S100A1
4adenoma30.7VHL, AMACR, S100A1, MUC3A, INHA, RASSF1
5nephrogenic adenoma30.6AMACR, S100A1, KRT7
6ovarian cancer30.6VHL, INHA, CXCR3, RASSF1, KRT7
7hepatitis30.6AMACR
8adenocarcinoma30.4VHL, AMACR, CA9, MUC3A, EPOR, CLDN7
9cystadenoma30.3VHL, INHA, KRT7
10meningioma30.3S100A1, INHA
11paraganglioma30.3FH, S100A1, VHL
12chordoma30.3S100A1, INHA, KRT7
13bladder carcinoma30.3FH, RASSF1, GSN
14cystic kidney30.3FH, VHL
15melanoma30.3AMACR, CA9, S100A1, MITF, EPOR, INHA
16lung adenocarcinoma30.3AMACR, MUC3A, RASSF1, KRT7
17squamous cell carcinoma30.3VHL, AMACR, CA9, S100A1, DEFB1, EPOR
18hemangioblastoma30.2INHA, EPOR, VHL
19pheochromocytoma30.2VHL, FH, EPOR, INHA
20lung cancer30.2VHL, AMACR, CA9, S100A1, MUC3A, CXCR3
21papillary carcinoma30.2AMACR, S100A1, KRT7
22renal oncocytoma30.2PVALB, S100A1, CDH16, KRT7
23kidney cancer30.2KRT7, TCEB2, CDH16, FH, CA9, AMACR
24retinoblastoma30.2PVALB, VHL, POLR2L, MITF, RASSF1
25endometrial carcinoma30.1CA9, INHA, RASSF1, KRT7
26gastric adenocarcinoma30.1EPOR, CLDN7, KRT7
27renal cell carcinoma11.2
28ovarian clear cell adenocarcinoma11.1
29urethra clear cell adenocarcinoma10.8
30ovary adenocarcinoma10.8
31vaginitis10.8
32urethra adenocarcinoma10.8
33bladder clear cell adenocarcinoma10.8
34endometriosis10.8
35bladder adenocarcinoma10.7
36thyroiditis10.7
37multilocular clear cell renal cell carcinoma10.7
38endometrial clear cell adenocarcinoma10.7
39urethritis10.6
40endometrial adenocarcinoma10.6
41adrenal carcinoma10.6
42cervical clear cell adenocarcinoma10.6
43urethral diverticulum10.5
44cervical adenocarcinoma10.5
45cervicitis10.5
46obesity10.5
47clear cell adenoma10.5
48fallopian tube clear cell adenocarcinoma10.4
49hereditary conventional renal cell carcinoma10.4
50small cell carcinoma10.4

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:



Diseases related to renal clear cell carcinoma

Clinical Features for Renal Clear Cell Carcinoma

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Drugs & Therapeutics for Renal Clear Cell Carcinoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Renal Clear Cell Carcinoma

Search CenterWatch for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

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Anatomical Context for Renal Clear Cell Carcinoma

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32MalaCards
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MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

32
Kidney, Endothelial, Thyroid, T cells, Bone, Breast, Tongue, Lung, Pancreas, Lymph node, Brain, Prostate, Ovary, Colon, Adrenal gland, Salivary gland, Smooth muscle, Liver, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000287310.3VHL, S100A1, MITF, EPOR, INHA, CXCR3
2MP:000537610.3AMACR, FH, MITF, CXCR3, AQP2, GSN
3MP:001076810.3GSN, VHL, AMACR, CA9, FH, DEFB1
4MP:000536710.1VHL, FH, DEFB1, CLDN7, CXCR3, KRT7

Publications for Renal Clear Cell Carcinoma

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50PubMed
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Articles related to Renal Clear Cell Carcinoma:

(show top 50)    (show all 788)
idTitleAuthorsYear
1
Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes. (24155122)
2014
2
Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma. (24387233)
2014
3
Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. (24166983)
2014
4
Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)
2013
5
Enhancer of zeste homolog 2 expression is associated with metastasis and adverse clinical outcome in clear cell renal cell carcinoma: a comparative study and review of the literature. (24079759)
2013
6
Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma. (24382589)
2013
7
Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature. (24228123)
2013
8
Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. (23382290)
2013
9
Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma. (23290145)
2013
10
Ki67 is an independent predictor of oncological outcomes in patients with localized clear-cell renal cell carcinoma. (23937277)
2013
11
The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. (23881929)
2013
12
Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)
2012
13
Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear cell renal cell carcinoma]. (22455137)
2012
14
CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. (22213152)
2012
15
Re: A. Rose Brannon, Scott M. Haake, Kathryn E. Hacker, et al. Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. Eur Urol 2012;61:258-68. (22790289)
2012
16
VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. (22516261)
2012
17
Coexistence of renal epithelioid angiomyolipoma and clear cell carcinoma in patients without tuberous sclerosis. (21742645)
2012
18
Association of RASSF1A genotype and haplotype with the progression of clear cell renal cell carcinoma in Japanese patients. (22520501)
2012
19
CD31 angiogenesis and combined expression of HIF-1I+ and HIF-2I+ are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFI+ transcriptional products are not: implications for antiangiogenic trials and HIFI+ biomarker studies in primary CC-RCC. (22777959)
2012
20
Angiomyolipoma with minimal fat: can it be differentiated from clear cell renal cell carcinoma by using standard MR techniques? (23012463)
2012
21
Carbonic anhydrase IX is expressed in mesothelioma and metastatic clear cell renal cell carcinoma of the lung. (22143934)
2012
22
The expression and clinical significance of Annexin II in clear-cell renal cell carcinoma]. (22230505)
2012
23
Clinical, molecular, and genetic correlates of lymphatic spread in clear cell renal cell carcinoma. (22269604)
2012
24
Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. (22030119)
2012
25
Time to recurrence after nephrectomy as a predictor of cancer-specific survival in localized clear-cell renal cell carcinoma. (20814191)
2011
26
The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma]. (22035911)
2011
27
Impact of postoperative C-reactive protein level on recurrence and prognosis in patients with N0M0 clear cell renal cell carcinoma. (21679988)
2011
28
The distinction of clear cell carcinoma of the female genital tract, clear cell renal cell carcinoma, and translocation-associated renal cell carcinoma: an immunohistochemical study using tissue microarray. (21804394)
2011
29
Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma. (20846263)
2010
30
Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. (20042676)
2010
31
Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment. (20709527)
2010
32
The use of immunohistochemistry in the diagnosis of metastatic clear cell renal cell carcinoma: a review of PAX-8, PAX-2, hKIM-1, RCCma, and CD10. (20966644)
2010
33
External validation of the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score for clear-cell renal cell carcinoma in a single European centre applying routine pathology. (19062157)
2010
34
Complexity of tumor vasculature in clear cell renal cell carcinoma. (19402071)
2009
35
The expression of thrombospondin-1 and p53 in clear cell renal cell carcinoma: its relationship to angiogenesis, cell proliferation and cancer specific survival. (19758660)
2009
36
High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. (18241036)
2008
37
Association of abnormal preoperative laboratory values with survival after radical nephrectomy for clinically confined clear cell renal cell carcinoma. (18308103)
2008
38
Computational pathology analysis of tissue microarrays predicts survival of renal clear cell carcinoma patients. (18982583)
2008
39
Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. (18496143)
2008
40
Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. (16985214)
2007
41
Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique. (16979727)
2006
42
Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. (16425993)
2005
43
Intradural spinal metastasis of renal clear cell carcinoma causing cauda equina syndrome. (15254809)
2004
44
Pathologic T1 clear cell renal cell carcinoma: insulin-like growth factor-I receptor expression and disease-specific survival. (15197799)
2004
45
Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (12576453)
2003
46
Gamna-Gandy nodules in a renal clear cell carcinoma. (12653589)
2003
47
Pheochromocytoma and clear-cell renal carcinoma in a child with von Hippel-Lindau disease: a patient report. (10417977)
1999
48
Renal clear cell carcinoma appearing as a left neck mass. (8870369)
1996
49
Metastatic renal clear cell carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology. (1878525)
1991
50
A thyroid metastasis revealing an occult renal clear-cell carcinoma. (3554676)
1987

Genetic Variations for Renal Clear Cell Carcinoma

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Expression for genes affiliated with Renal Clear Cell Carcinoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

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37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Renal Clear Cell Carcinoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB, 2BitterDB
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Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8PVALB
2fumarate44 1111.8FH, AMACR, VHL
3hematoxylin4410.7AMACR, S100A1, INHA, KRT7
4biotin44 11 2412.7AQP2, INHA, S100A1, AMACR
5streptavidin4410.7KRT7, EPOR, AMACR
65-aza-2deoxycytidine4410.7VHL, CA9, POLR2L, RASSF1, KRT7
7methionine4410.7PVALB, AMACR, RASSF1, AQP2, GSN
8glucose4410.7AMACR, CA9, DEFB1, TCEB2, KRT7, AQP2
9oligonucleotide4410.7VHL, AMACR, POLR2L, MITF, MUC3A, EPOR
10paraffin4410.7PVALB, AMACR, CA9, S100A1, MITF, EPOR
11progesterone44 59 28 11 2414.7AMACR, CA9, S100A1, MUC3A, INHA, CXCR3
12oxygen44 2411.7VHL, CA9, FH, MITF, EPOR, CXCR3
13steroid4410.7MUC3A, EPOR, INHA, CXCR3, AQP2, GSN
14vegf4410.7VHL, CA9, POLR2L, EPOR, CXCR3, TCEB2
15proline4410.7VHL, CA9, FH, POLR2L, EPOR
16calcium44 49 11 2413.6S100A1, CA9, AMACR, VHL, PVALB, MITF
17iron44 2411.6PVALB, VHL, S100A1, EPOR, KRT7
18tyrosine4410.6S100A1, CA9, AMACR, VHL, PVALB, FH
19hydrogen44 2411.6CA9, S100A1, FH, INHA, AQP2
20retinoic acid44 2411.6AMACR, S100A1, DEFB1, POLR2L, RASSF1, KRT7
21serine4410.6PVALB, VHL, POLR2L, EPOR, CXCR3, RASSF1
22pimonidazole4410.6EPOR, CA9
23chloride4410.6PVALB, AMACR, CA9, AQP2
24arginine4410.6POLR2L, MITF, EPOR, CXCR3, KRT7, AQP2
25nitric oxide44 11 2412.6PVALB, VHL, S100A1, EPOR, CXCR3, AQP2
26silver4410.6PVALB, S100A1, MITF
27nad+4410.5INHA, FH, PVALB
28cysteine4410.5AMACR, S100A1, POLR2L, EPOR, AQP2, GSN
29glycogen44 2411.4VHL, S100A1, KRT7, GSN
30testosterone44 59 11 2413.4AMACR, POLR2L, INHA, KRT7, GSN
31azathioprine44 49 2 1113.3GSN, RASSF1, POLR2L
32mucicarmine4410.1KRT7, S100A1

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

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16Gene Ontology
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Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:04323410.4GSN, AQP2, MITF, S100A1

Biological processes related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145610.4TCEB2, CA9, VHL
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.1TCEB2, CA9, VHL

Products for genes affiliated with Renal Clear Cell Carcinoma

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Sources for Renal Clear Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet