Renal Clear Cell Carcinoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Renal Clear Cell Carcinoma

Sources:
⁹Disease Ontology, ³²MalaCards
See all sources

Disease Ontology:⁹ A renal cell carcinoma that has material basis in cells that appear very pale or clear when examined under microscope.

MalaCards based summary: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to von hippel-lindau disease and cystadenoma. An important gene associated with Renal Clear Cell Carcinoma is HNF1A (HNF1 homeobox A), and among its related pathways is Glucose / Energy Metabolism. The compounds fumarate and biotin have been mentioned in the context of this disorder. Affiliated tissues include kidney, thyroid and tongue, and related mouse phenotypes are liver/biliary system and renal/urinary system.

Aliases & Classifications for Renal Clear Cell Carcinoma

Sources:
⁴⁸Orphanet, ⁹Disease Ontology, ¹¹DISEASES, ⁴⁴Novoseek, ⁶¹UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt, ²⁷ICD10 via Orphanet
See all sources

Renal Clear Cell Carcinoma, Aliases & Descriptions:

Name: Renal Clear Cell Carcinoma ⁹ ¹¹ ⁴⁴

Conventional Renal Cell Carcinoma ⁹ ⁶¹

Clear Cell Renal Cell Carcinoma ⁴⁸ ⁶¹

Clear Cell Carcinoma of Kidney ⁹ ⁶¹

Clear Cell Kidney Carcinoma ⁹ ⁶¹

Clear Cell Renal Cell Adenocarcinoma ⁴⁸

Conventional Renal Cell Carcinoma ⁹

Clear Cell Renal Carcinoma ⁴⁸

Adenocarcinoma, Clear Cell ⁶¹

Clear Cell Adenocarcinoma ⁴⁸

Ccrcc ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Cancer diseases, Rare diseases
Anatomical: Nephrological diseases

ICD10: ²⁷

Neoplasms

Malignant neoplasms of urinary tract

Malignant neoplasm of kidney, except renal pelvis

Orphanet: ⁴⁸

Rare renal diseases

Rare tumors

External Ids:

Disease Ontology⁹ DOID:4467

MeSH³⁴ C538445, D002292

SNOMED-CT⁵⁶ 254915003, 41607009, 188251003

NCIt³⁹ C4033

ICD10 via Orphanet²⁷ C64

UMLS⁶¹ C0279702

Related Diseases for Renal Clear Cell Carcinoma

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma	Hereditary Renal Cell Carcinoma
Familial Renal Cell Carcinoma	Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 151)

id	Related Disease	Score	Top Affiliating Genes
1	von hippel-lindau disease	31.0	VHL, TMEM127, INHA
2	cystadenoma	31.0	VHL, INHA
3	polycythemia	30.8	VHL, EPOR
4	paraganglioma	30.6	VHL, FH, TMEM127
5	hemangioblastoma	30.6	VHL, EPOR, INHA
6	ovarian cancer	30.6	INHA, AMACR, MUC3A, GSN
7	wilms tumor	30.5	VHL, AMACR, INHA
8	pheochromocytoma	30.4	INHA, EPOR, FH, VHL
9	kidney cancer	30.1	AMACR, FH, VHL, HNF1A, CDH16
10	adenoma	30.0	INHA, AMACR, MUC3A, VHL, HNF1A, GSN
11	adenocarcinoma	29.8	INHA, AMACR, EPOR, MUC3A, FOLH1, VHL
12	melanoma	29.7	INHA, AMACR, EPOR, CXCR3, FOLH1, GSN
13	lung cancer	29.5	AMACR, MUC3A, CXCR3, VHL, HNF1A, GSN
14	ovarian clear cell adenocarcinoma	11.1
15	vaginitis	10.8
16	endometriosis	10.8
17	thyroiditis	10.7
18	urethritis	10.7
19	papillary renal cell carcinoma	10.6
20	multilocular clear cell renal cell carcinoma	10.6
21	angiomyolipoma	10.6
22	clear cell papillary renal cell carcinoma	10.6
23	urethral diverticulum	10.6
24	cervicitis	10.6
25	obesity	10.5
26	cervical clear cell adenocarcinoma	10.5
27	hypoxia	10.5
28	nephrogenic adenoma	10.5
29	urethra clear cell adenocarcinoma	10.5
30	endometrial clear cell adenocarcinoma	10.5
31	prostatitis	10.5
32	clear cell adenocarcinoma of ovary	10.5
33	fumarate hydratase deficiency	10.5	FH
34	hereditary conventional renal cell carcinoma	10.4
35	hemangioma	10.4
36	hepatitis	10.4
37	hepatitis a	10.4
38	chromosome 9p deletion	10.4
39	adenofibroma	10.4
40	bile duct clear cell adenocarcinoma	10.4
41	uterine ligament clear cell adenocarcinoma	10.4
42	fallopian tube clear cell adenocarcinoma	10.4
43	ampulla of vater clear cell adenocarcinoma	10.4
44	bladder tubulo-cystic clear cell adenocarcinoma	10.4
45	bladder papillary clear cell adenocarcinoma	10.4
46	bladder clear cell adenocarcinoma	10.4
47	peritonitis	10.4
48	pancreatitis	10.4
49	primary polycythemia	10.4	VHL, EPOR
50	chromophobe renal cell carcinoma	10.4

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:

Symptoms for Renal Clear Cell Carcinoma

Drugs & Therapeutics for Renal Clear Cell Carcinoma

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

Anatomical Context for Renal Clear Cell Carcinoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

³²

Kidney, Thyroid, Tongue, Bone, Liver, Lung, Pancreas, Salivary gland, Breast, Tonsil, Endothelial, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.7	INHA, AMACR, EPOR, VHL, HNF1A
2	renal/urinary system phenotype	MP:0005367	8.4	DEFB1, AQP2, CXCR3, FH, VHL, HNF1A
3	hematopoietic system phenotype	MP:0005397	7.7	GSN, VHL, CXCR3, EPOR, AQP2, INHA
4	cardiovascular system phenotype	MP:0005385	7.1	INHA, EPOR, CXCR3, FOLH1, VHL, GSN
5	mortality/aging	MP:0010768	6.5	DEFB1, INHA, AMACR, AQP2, EPOR, CXCR3
6	homeostasis/metabolism phenotype	MP:0005376	6.2	GSN, INHA, AMACR, AQP2, EPOR, CXCR3

Publications for Renal Clear Cell Carcinoma

Sources:
⁵¹PubMed
See all sources

Articles related to Renal Clear Cell Carcinoma:

(show top 50) (show all 118)

id	Title	Authors	Year
1	Neoadjuvant sunitinib effectiveness in T4 renal clear cell carcinoma: a case report. (25050998)	Ricciardulli S.... Celia A.	2014
2	Tumor-specific hypermethylation of epigenetic biomarkers, including SFRP1, predicts for poorer survival in patients from the TCGA Kidney Renal Clear Cell Carcinoma (KIRC) project. (24454902)	Ricketts C.J.... Linehan W.M.	2014
3	Identification of angiogenesis-related miRNAs in a population of patients with renal clear cell carcinoma. (25119741)	Li H.C.... Chong T.	2014
4	The Expression and Role of MEKK3 in Renal Clear Cell Carcinoma. (25388155)	Lu H.... Gan M.	2014
5	Bilateral synchronous multifocal renal clear-cell carcinoma. (23627203)	Pothen L.... Lambert M.	2013
6	Paraneoplastic symptoms: cachexia, polycythemia, and hypercalcemia are, respectively, related to vascular endothelial growth factor (VEGF) expression in renal clear cell carcinoma. (22534085)	Ding G.X.... Ding Q.	2013
7	Multiphasic contrast-enhanced MRI: single-slice versus volumetric quantification of tumor enhancement for the assessment of renal clear-cell carcinoma fuhrman grade. (23152173)	Vargas H.A.... Akin O.	2013
8	Osteomalacia-inducing renal clear cell carcinoma uncovered by 99mTc-Hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC) scintigraphy. (24089059)	Jin X.... Zhuang H.	2013
9	Hypoxia-inducible factor 1I+ mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma. (23611775)	Gao Y.H.... Wang L.S.	2013
10	Lower mRNA and protein expression levels of LC3 and Beclin1, markers of autophagy, were correlated with progression of renal clear cell carcinoma. (24186908)	Deng Q.... Chong T.	2013
11	Fine-needle aspiration cytology of renal clear cell carcinoma metastatic to the thyroid gland. (23729320)	Narine N.... Perera D.M.	2013
12	Subtotal distal pancreatectomy for metachronous metastatic renal clear cell carcinoma. (23368657)	Aguayo-Albasini J.L.... Mengual-Ballester M.	2012
13	Expression and prognostic significance of Src family members in renal clear cell carcinoma. (22814579)	Qayyum T.... Edwards J.	2012
14	Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma. (21544807)	Nagata M.... Murakami Y.	2012
15	Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma. (23467480)	Cai J.L.... Na Y.Q.	2011
16	Stage pT3a of renal clear cell carcinoma: do tumors with sinus fat involvement behave the same as those with perinephric fat involvement? (21655644)	Chaves Portela S.... Paniagua P.	2011
17	Genetic heterogeneity and chromatin modifiers in renal clear cell carcinoma. (20528227)	Staller P.	2010
18	Angiotensin-2 receptors (AT1-R and AT2-R), new prognostic factors for renal clear-cell carcinoma? (21102591)	Dolley-Hitze T.... Vigneau C.	2010
19	The expression and clinical significance of TGF-beta1 and MMP2 in human renal clear cell carcinoma. (19223381)	Yang S.D.... Zhou Z.Y.	2010
20	A novel resveratrol analogue HS-1793 treatment overcomes the resistance conferred by Bcl-2 and is associated with the formation of mature PML nuclear bodies in renal clear cell carcinoma Caki-1 cells. (19885558)	Jeong S.H.... Yoo Y.H.	2009
21	Microarray analysis of microRNA expression in renal clear cell carcinoma. (19443172)	Huang Y.... Zhang L.	2009
22	Contrast-enhanced ultrasound for detection and diagnosis of renal clear cell carcinoma. (19493467)	Dong X.Q.... Wang X.M.	2009
23	Two novel VHL targets, TGFBI (BIGH3) and its transactivator KLF10, are up-regulated in renal clear cell carcinoma and other tumors. (18359287)	Ivanov S.V.... Lerman M.I.	2008
24	Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. (18006011)	Seligson D.B.... Rajasekaran A.K.	2008
25	A comprehensive prognostic stratification for patients with metastatic renal clear cell carcinoma. (18581596)	Cho K.S.... Hong S.J.	2008
26	Loss of PL6 protein expression in renal clear cell carcinomas and other VHL-deficient tumours. (17973242)	Ivanova A.V.... Lerman M.I.	2008
27	High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. (17922474)	Yoshimoto T.... Moriyama M.	2007
28	Metastatic renal clear cell carcinoma in the parotid gland: a study of immunohistochemical profile and cell adhesion molecules (CAMs) expression in two cases. (17607380)	Andreadis D.... Barbatis C.	2007
29	Transient massive peripheral blood blastosis in patient with renal clear-cell carcinoma after treatment with high-dose recombinant interleuklin-2. (17329199)	del Mar Osma M.... Vicente V.	2007
30	Solitary metachronous metastasis to the thyroid from renal clear cell carcinoma 19 years after nephrectomy: report of a case. (15912297)	Wada N.... Takanashi Y.	2005
31	Diffuse expression of MUC 1 in metastases of renal clear cell carcinoma as a possible therapeutic target for renal cancer. (16178902)	Leroy X.... Copin M.C.	2005
32	Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. (15968199)	Ohta Y.... Ota H.	2005
33	Decreased expression of REIC/Dkk-3 in human renal clear cell carcinoma. (14767340)	Kurose K.... Huh N.H.	2004
34	Somatic mutations of VHL gene and HIF-1alpha expression in primary renal clear cell carcinomas]. (15062033)	Guo H.F.... Na Y.Q.	2004
35	Differentiation of renal clear cell carcinoma and renal papillary carcinoma using quantitative CT enhancement parameters. (15505308)	Ruppert-Kohlmayr A.J.... Ruppert G.	2004
36	Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. (15126876)	Bui M.H.... Belldegrun A.S.	2004
37	Intradural spinal metastasis of renal clear cell carcinoma causing cauda equina syndrome. (15254809)	Gaetani P.... Rodriguez y Baena R.	2004
38	The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma. (15180922)	Sufan R.I.... Ohh M.	2004
39	Increased expression and altered location of annexin IV in renal clear cell carcinoma: a possible role in tumour dissemination. (15145526)	Zimmermann U.... Walther R.	2004
40	Metastatic renal clear cell carcinoma mimicking stage IV lung cancer. (14620276)	Griniatsos J.... Bastounis E.	2003
41	Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (12576453)	Bui M.H.... Belldegrun A.S.	2003
42	Fatty metastatic lesions in 2 patients with renal clear-cell carcinoma. (14600452)	Muram T.M.... Aisen A.	2003
43	Expression of the angiopoietins and their receptor Tie2 in human renal clear cell carcinomas; regulation by the von Hippel-Lindau gene and hypoxia. (12434420)	Currie M.J.... Fox S.B.	2002
44	Type I 5'-iodothyronine deiodinase activity and mRNA are remarkably reduced in renal clear cell carcinoma. (11383912)	Pachucki J.... Nauman A.	2001
45	Thyroid metastases from renal clear cell carcinoma: a cyto-histological study of two cases. (11753829)	Ambrosiani L.... Bianchi A.	2001
46	Correlation of CD44S expression in renal clear cell carcinomas with subsequent tumor progression or recurrence. (10590373)	Gilcrease M.Z.... Albores-Saavedra J.	1999
47	Metastatic renal clear cell carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology. (1878525)	Rikabi A.C.... Wilson C.	1991
48	Metastatic renal clear cell carcinoma of the jaws. Two cases illustrating clinical and pathological diagnostic problems. (2135656)	Jones G.M.... Eveson J.W.	1990
49	Late results of surgical treatment of renal clear-cell carcinoma. (3721763)	Czaplicki M.... Milewski J.B.	1986
50	ELECTRON MICROSCOPIC OBSERVATIONS ON SPECIALIZATIONS OF THE CELL SURFACE IN RENAL CLEAR CELL CARCINOMA. (14279879)	Seljelid R.... Ericsson J.L.	1965

Genes related to Renal Clear Cell Carcinoma

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals, ⁷Clinvar, ⁴⁸Orphanet
See all sources

Genes related to Renal Clear Cell Carcinoma:

(show all 14)

- Elite gene

id	Symbol	Description	Score	Implication
1	HNF1A	HNF1 homeobox A	20.00	Pathogenic ⁷
2	TMEM127	transmembrane protein 127	18.57	Susceptibility factor ⁴⁸
3	MUC3A	mucin 3A, cell surface associated	17.89	GeneCards inferred via : Publications, Disorders (show sections)
4	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	16.46	GeneCards inferred via : Publications, Disorders (show sections)
5	DEFB1	defensin, beta 1	15.03	GeneCards inferred via : Disorders (show sections)
6	AMACR	alpha-methylacyl-CoA racemase	13.60	GeneCards inferred via : Disorders (show sections)
7	AQP2	aquaporin 2 (collecting duct)	12.17	GeneCards inferred via : Disorders (show sections)
8	EPOR	erythropoietin receptor	10.75	GeneCards inferred via : Disorders (show sections)
9	FH	fumarate hydratase	9.32	GeneCards inferred via : Disorders (show sections)
10	INHA	inhibin, alpha	7.89	GeneCards inferred via : Disorders (show sections)
11	CXCR3	chemokine (C-X-C motif) receptor 3	6.46	GeneCards inferred via : Disorders (show sections)
12	FOLH1	folate hydrolase (prostate-specific membrane antigen) 1	5.03	GeneCards inferred via : Disorders (show sections)
13	GSN	gelsolin	3.60	GeneCards inferred via : Publications, Disorders (show sections)
14	CDH16	cadherin 16, KSP-cadherin	2.17	GeneCards inferred via : Disorders (show sections)

Products for genes related to Renal Clear Cell Carcinoma disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	13	-	14	14
2	Novus Biologicals	11	11	13	-

Variations for Renal Clear Cell Carcinoma

Sources:
⁷Clinvar
See all sources

Clinvar genetic disease variations for Renal Clear Cell Carcinoma:

⁷

id	Gene	Name	Type	Significance	SNP ID	Assembly	Location
1	HNF1A	NM_000545.5(HNF1A): c.872dupC (p.Gly292Argfs)	duplication	Pathogenic		GRCh37	Chr 12, 121432125: 121432125

Expression for genes affiliated with Renal Clear Cell Carcinoma

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

Sources:
⁴⁹PathCards, ⁵Cell Signaling Technology
See all sources

Pathways related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Glucose / Energy Metabolism⁵	9.2	HNF1A, FH, AQP2, AMACR

Compounds for genes affiliated with Renal Clear Cell Carcinoma

Sources:
⁴⁴Novoseek, ¹²DrugBank, ²⁵HMDB, ²⁹IUPHAR, ⁵⁰PharmGKB, ⁶⁰Tocris Bioscience
See all sources

Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 29)

id	Compound	Score	Top Affiliating Genes
1	fumarate⁴⁴ ¹²	10.8	VHL, FH, AMACR
2	biotin⁴⁴ ²⁵ ¹²	11.7	AQP2, AMACR, INHA
3	streptavidin⁴⁴	9.5	FOLH1, EPOR, AMACR
4	cobalt⁴⁴ ²⁵	10.5	VHL, FOLH1
5	proline⁴⁴	9.5	EPOR, FH, VHL, HNF1A
6	aldose⁴⁴	9.5	GSN, AQP2
7	cholesterol⁴⁴ ²⁹ ²⁵ ¹²	12.3	AMACR, MUC3A, CXCR3, HNF1A
8	creatinine⁴⁴	9.2	HNF1A, FH, CXCR3, AQP2
9	dexamethasone⁴⁴ ⁵⁰ ²⁹ ¹²	12.1	HNF1A, CXCR3, AQP2, AMACR, DEFB1
10	methionine⁴⁴	9.0	GSN, AQP2, AMACR
11	thymidine⁴⁴ ²⁵	10.0	EPOR, CXCR3, FOLH1, HNF1A
12	progesterone⁴⁴ ²⁹ ⁶⁰ ²⁵ ¹²	12.9	INHA, AMACR, AQP2, MUC3A, CXCR3
13	vegf⁴⁴	8.8	EPOR, CXCR3, FOLH1, VHL
14	nitric oxide⁴⁴ ²⁵ ¹²	10.7	AQP2, EPOR, CXCR3, VHL
15	lipid⁴⁴	8.6	AMACR, AQP2, EPOR, HNF1A, GSN
16	fatty acid⁴⁴	8.6	INHA, AMACR, FH, HNF1A, GSN
17	phosphatidylinositol⁴⁴	8.5	EPOR, CXCR3, VHL, GSN
18	testosterone⁴⁴ ⁶⁰ ²⁵ ¹²	11.5	GSN, FOLH1, AMACR, INHA
19	estrogen⁴⁴	8.4	INHA, AMACR, EPOR, MUC3A, CXCR3, VHL
20	oxygen⁴⁴ ²⁵	9.3	EPOR, CXCR3, FH, VHL, GSN
21	glutamate⁴⁴	8.3	GSN, FOLH1, EPOR, AMACR
22	cysteine⁴⁴	8.3	GSN, FOLH1, EPOR, AQP2, AMACR
23	alanine⁴⁴	8.2	INHA, AQP2, EPOR, FOLH1, GSN
24	oligonucleotide⁴⁴	8.1	INHA, AMACR, EPOR, MUC3A, VHL, HNF1A
25	steroid⁴⁴	7.8	INHA, AQP2, EPOR, MUC3A, CXCR3, HNF1A
26	serine⁴⁴	7.8	AQP2, EPOR, CXCR3, FOLH1, VHL, GSN
27	glucose⁴⁴	7.8	GSN, DEFB1, AMACR, AQP2, EPOR, FH
28	tyrosine⁴⁴	7.4	INHA, AMACR, EPOR, CXCR3, FH, VHL
29	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	10.4	AMACR, AQP2, EPOR, MUC3A, CXCR3, VHL