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CCRCC
MCID: RNL003
MIFTS: 53

Renal Clear Cell Carcinoma (CCRCC) malady

Nephrological, Cancer categories
92 genes, 21 tissues, 176 related diseases, clinical trials.

Summaries for Renal Clear Cell Carcinoma

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8Disease Ontology, 33MalaCards
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Disease Ontology:8 A renal cell carcinoma that is the most common type of renal cell carcinoma. the cancerous cells appear very pale or clear when examined under microscope. this cancer can be effectively treated with surgery if the tumor is confined to the kidney.

MalaCards: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to adenoma and angiomyolipoma. An important gene associated with Renal Clear Cell Carcinoma is MITF (microphthalmia-associated transcription factor), and among its related pathways are Hypoxic and oxygen homeostasis regulation of HIF-1-alpha and Cellular response to hypoxia. The compounds estrogen and fumarate have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and brain, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Renal Clear Cell Carcinoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 49Orphanet, 35MeSH, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Nephrological
ICD10: 26


Aliases & Descriptions:

renal clear cell carcinoma 8 10 45
conventional renal cell carcinoma 8 61
clear cell renal cell adenocarcinoma 49
conventional renal cell carcinoma 8
clear cell renal cell carcinoma 49
clear cell carcinoma of kidney 8
clear cell renal carcinoma 49
adenocarcinoma, clear cell 61
clear cell adenocarcinoma 49
ccrcc 49


External Ids:

Disease Ontology8 DOID:4467
NCIt40 C4033
ICD10 via Orphanet26 C64

Related Diseases for Renal Clear Cell Carcinoma

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17GeneCards, 18GeneDecks
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Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 176)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.7GSN, MUC3A, VHL, INHA, RASSF1, KRT7
2angiomyolipoma30.7S100A1, MITF
3nephrogenic adenoma30.7AMACR, S100A1, KRT7
4adenocarcinoma30.5KRT7, GSN, VHL, INHA, MUC3A, AMACR
5cystadenoma30.4KRT7, INHA, VHL
6paraganglioma30.4FH, VHL, S100A1
7squamous cell carcinoma30.4AMACR, CLDN7, INHA, RASSF1, CA9, DEFB1
8bladder carcinoma30.4GSN, RASSF1, FH
9pheochromocytoma30.3EPOR, VHL, FH, INHA
10papillary carcinoma30.3S100A1, AMACR, KRT7
11wilms tumor30.1INHA, KRT7, VHL, AMACR, RASSF1
12clear cell renal cell carcinoma11.2
13ovarian clear cell adenocarcinoma11.1
14urethra clear cell adenocarcinoma10.9
15urethra adenocarcinoma10.9
16bladder clear cell adenocarcinoma10.8
17bladder adenocarcinoma10.8
18endometrial clear cell adenocarcinoma10.7
19multilocular clear cell renal cell carcinoma10.7
20cervical clear cell adenocarcinoma10.6
21adrenal carcinoma10.6
22urethral diverticulum10.5
23clear cell adenoma10.5
24clear cell adenofibroma10.5
25adenofibroma10.5
26hypoxia10.5
27fallopian tube clear cell adenocarcinoma10.5
28renal cell carcinoma, clear cell, somatic10.4
29renal cell carcinoma, somatic10.4
30hereditary conventional renal cell carcinoma10.4
31ovarian endometriosis10.4
32ovarian epithelial cancer10.4
33hepatitis c10.4
34small cell carcinoma10.4
35hepatitis b10.4
36granular cell carcinoma10.4
37large cell carcinoma10.4
38adrenocortical carcinoma10.4
39hepatitis c virus10.4
40bile duct clear cell adenocarcinoma10.3
41bladder diffuse clear cell adenocarcinoma10.3
42bladder tubulo-cystic clear cell adenocarcinoma10.3
43bladder papillary clear cell adenocarcinoma10.3
44uterine ligament clear cell adenocarcinoma10.3
45ampulla of vater clear cell adenocarcinoma10.3
46clear cell adenocarcinoma10.3
47chromophobe renal cell carcinoma10.3
48ovary rhabdomyosarcoma10.3
49mucinous adenocarcinoma10.3
50ureter adenocarcinoma10.3

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:



Diseases related to renal clear cell carcinoma

Clinical Features for Renal Clear Cell Carcinoma

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Drugs & Therapeutics for Renal Clear Cell Carcinoma

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Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Renal Clear Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Search CenterWatch for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

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Anatomical Context for Renal Clear Cell Carcinoma

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33MalaCards
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MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

33
Whole blood, Lymph node, Brain, Smooth muscle, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Ovary, Prostate, T cells, B cells, Endothelial, Tongue, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

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37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1
normal phenotype
MP:000287310.3VHL, S100A1, MITF, EPOR, INHA, CXCR3
2
homeostasis/metabolism phenotype
MP:000537610.3AMACR, FH, MITF, CXCR3, AQP2, GSN
3
mortality/aging
MP:001076810.3GSN, VHL, AMACR, CA9, FH, DEFB1
4
renal/urinary system phenotype
MP:000536710.1VHL, FH, DEFB1, CLDN7, CXCR3, KRT7

Publications for Renal Clear Cell Carcinoma

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51PubMed
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Articles related to Renal Clear Cell Carcinoma:

(show top 50)    (show all 790)
idTitleAuthorsYear
1
Dicer is down-regulated in clear cell renal cell carcinoma and in vitro Dicer knockdown enhances malignant phenotype transformation. (24094887)
2014
2
Roles of transcriptional factor Snail and adhesion factor E-cadherin in clear cell renal cell carcinoma. (24255679)
2013
3
Molecular imaging and carbonic anhydrase IX-targeted radioimmunotherapy in clear cell renal cell carcinoma. (23638744)
2013
4
Tumor-associated macrophages subvert T-cell function and correlate with reduced survival in clear cell renal cell carcinoma. (23687622)
2013
5
Indium-111-labeled girentuximab immunoSPECT as a diagnostic tool in clear cell renal cell carcinoma. (23453421)
2013
6
Lower mRNA and protein expression levels of LC3 and Beclin1, markers of autophagy, were correlated with progression of renal clear cell carcinoma. (24186908)
2013
7
Imaging the clear cell renal cell carcinoma proteome. (23009866)
2013
8
A novel grading system for clear cell renal cell carcinoma incorporating tumor necrosis. (23348209)
2013
9
Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma. (23982215)
2013
10
Carbonic Anhydrase IX is not a predictor of outcomes in non-metastatic clear cell renal cell carcinoma - a digital analysis of tissue microarray. (24054396)
2013
11
JAK3 in clear cell renal cell carcinoma: mutational screening and clinical implications. (21868263)
2013
12
Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. (23238627)
2013
13
Simultaneous renal clear cell carcinoma and gastrointestinal stromal tumor in one case. (23798873)
2013
14
Cutaneous metastasis from renal clear cell carcinoma. (23648755)
2013
15
Evaluating rational non-cross-resistant combination therapy in advanced clear cell renal cell carcinoma: combined mTOR and AKT inhibitor therapy. (21644050)
2012
16
High-level expression of Notch1 increased the risk of metastasis in T1 stage clear cell renal cell carcinoma. (22506064)
2012
17
Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition. (21992819)
2012
18
'Prechronous' metastasis in clear cell renal cell carcinoma: a case report. (21569512)
2011
19
Tumour suppressor microRNA-584 directly targets oncogene Rock-1 and decreases invasion ability in human clear cell renal cell carcinoma. (21119662)
2011
20
Specificity of brachyury in the distinction of chordoma from clear cell renal cell carcinoma and germ cell tumors: a study of 305 cases. (21102418)
2011
21
External validation of the Leibovich prognosis score for nonmetastatic clear cell renal cell carcinoma at a single European center applying routine pathology. (21944989)
2011
22
HtrA3 is regulated by 15-deoxy-Delta12,14-prostaglandin J2 independently of PPARgamma in clear cell renal cell carcinomas. (19951697)
2010
23
Metastatic renal cell carcinoma to the oral cavity and clear cell mucoepidermoid carcinoma: comparative clinicopathologic and immunohistochemical study. (20303042)
2010
24
MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens. (20593407)
2010
25
Vascular endocan (ESM-1) is markedly overexpressed in clear cell renal cell carcinoma. (20102396)
2010
26
Editorial comment on: external validation of the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score for clear-cell renal cell carcinoma in a single European centre applying routine pathology. (19062158)
2010
27
CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma. (19922654)
2009
28
MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. (19549898)
2009
29
The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma. (19384955)
2009
30
Evidence for polyclonal origin of multifocal clear cell renal cell carcinoma. (19088024)
2008
31
Expression of CD24 in clear cell renal cell carcinoma and its prognostic significance. (18384848)
2008
32
High-resolution analysis of DNA copy number alterations and gene expression in renal clear cell carcinoma. (17922474)
2007
33
Down-regulation of HLA class I antigen is an independent prognostic factor for clear cell renal cell carcinoma. (17382705)
2007
34
Two distinct types of blood vessels in clear cell renal cell carcinoma have contrasting prognostic implications. (17200351)
2007
35
Renal veins and venous extension in clear cell renal cell carcinoma. (17170742)
2007
36
Expression of cytokeratin 5 and calretinin in clear-cell renal cell carcinoma]. (16838608)
2006
37
Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma. (16865223)
2006
38
Prognostic significance of multidrug-resistance protein (MDR-1) in renal clear cell carcinomas: a five year follow-up analysis. (17177989)
2006
39
Cytohistopathologic hybrid renal cell carcinoma with papillary and clear cell features. (17034957)
2006
40
mRNA expression analysis of metastatic markers in clear-cell renal cell carcinoma]. (18035688)
2005
41
Renal clear-cell carcinoma: an ultrastructural study on the junctional complexes. (15578420)
2005
42
Prognostic implications of CD95 receptor expression in clear cell renal carcinomas. (12612886)
2003
43
Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. (12670587)
2003
44
Altered pattern of major histocompatibility complex expression in renal carcinoma: tumor-specific expression of the nonclassical human leukocyte antigen-G molecule is restricted to clear cell carcinoma while up-regulation of other major histocompatibility complex antigens is primarily distributed in all subtypes of renal carcinoma. (12547708)
2003
45
Clear cell endocrine pancreatic tumor mimicking renal cell carcinoma: a distinctive neoplasm of von Hippel-Lindau disease. (11342771)
2001
46
Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. (11585766)
2001
47
Metastasis of clear-cell renal carcinoma to cerebellar hemangioblastoma in von Hippel Lindau disease: rare or not investigated? (11685614)
2001
48
Papillary renal carcinoma (clear cell type) arising in the escretory urothelial district: a very unusual feature. (10936898)
2000
49
Expression of MUC1, Thomsen-Friedenreich-related antigens, and cytokeratin 19 in human renal cell carcinomas and tubular clear cell lesions. (10755601)
2000
50
Absence or reduction of Fhit expression in most clear cell renal carcinomas. (9679951)
1998

Genetic Variations for Renal Clear Cell Carcinoma

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Expression for genes affiliated with Renal Clear Cell Carcinoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

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38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 30KEGG
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Pathways related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha38
10.4TCEB2, VHL
2
Cellular response to hypoxia54
Hide members
10.4VHL, CA9, TCEB2
3
Glucose / Energy Metabolism4
10.4AQP2, FH, AMACR, CA9
4
Pathways in cancer30
10.4TCEB2, VHL, FH, MITF, RASSF1

Compounds for genes affiliated with Renal Clear Cell Carcinoma

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45Novoseek, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB, 2BitterDB
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Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8PVALB
2fumarate45 1111.8FH, AMACR, VHL
3hematoxylin4510.7AMACR, S100A1, INHA, KRT7
4biotin45 11 2412.7AQP2, INHA, S100A1, AMACR
5streptavidin4510.7KRT7, EPOR, AMACR
65-aza-2deoxycytidine4510.7VHL, CA9, POLR2L, RASSF1, KRT7
7methionine4510.7PVALB, AMACR, RASSF1, AQP2, GSN
8glucose4510.7AMACR, CA9, DEFB1, TCEB2, KRT7, AQP2
9oligonucleotide4510.7VHL, AMACR, POLR2L, MITF, MUC3A, EPOR
10paraffin4510.7PVALB, AMACR, CA9, S100A1, MITF, EPOR
11progesterone45 60 29 11 2414.7AMACR, CA9, S100A1, MUC3A, INHA, CXCR3
12oxygen45 2411.7VHL, CA9, FH, MITF, EPOR, CXCR3
13steroid4510.7MUC3A, EPOR, INHA, CXCR3, AQP2, GSN
14vegf4510.7VHL, CA9, POLR2L, EPOR, CXCR3, TCEB2
15proline4510.7VHL, CA9, FH, POLR2L, EPOR
16calcium45 50 11 2413.6S100A1, CA9, AMACR, VHL, PVALB, MITF
17iron45 2411.6PVALB, VHL, S100A1, EPOR, KRT7
18tyrosine4510.6S100A1, CA9, AMACR, VHL, PVALB, FH
19hydrogen45 2411.6CA9, S100A1, FH, INHA, AQP2
20retinoic acid45 2411.6AMACR, S100A1, DEFB1, POLR2L, RASSF1, KRT7
21serine4510.6PVALB, VHL, POLR2L, EPOR, CXCR3, RASSF1
22pimonidazole4510.6EPOR, CA9
23chloride4510.6PVALB, AMACR, CA9, AQP2
24arginine4510.6POLR2L, MITF, EPOR, CXCR3, KRT7, AQP2
25nitric oxide45 11 2412.6PVALB, VHL, S100A1, EPOR, CXCR3, AQP2
26silver4510.6PVALB, S100A1, MITF
27nad+4510.5INHA, FH, PVALB
28cysteine4510.5AMACR, S100A1, POLR2L, EPOR, AQP2, GSN
29glycogen45 2411.4VHL, S100A1, KRT7, GSN
30testosterone45 60 11 2413.4AMACR, POLR2L, INHA, KRT7, GSN
31azathioprine45 50 2 1113.3GSN, RASSF1, POLR2L
32mucicarmine4510.1KRT7, S100A1

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

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16Gene Ontology
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Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein complexGO:04323410.4GSN, AQP2, MITF, S100A1

Biological processes related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cellular response to hypoxiaGO:07145610.4TCEB2, CA9, VHL
2regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.1TCEB2, CA9, VHL

Products for genes affiliated with Renal Clear Cell Carcinoma

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Sources for Renal Clear Cell Carcinoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet
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