Renal Clear Cell Carcinoma disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

CCRCC MCID: RNL003 MIFTS: 58	Renal Clear Cell Carcinoma (CCRCC) malady Nephrological diseases, Cancer diseases categories
92 genes, 19 tissues, 199 related diseases, clinical trials.

Summaries for Renal Clear Cell Carcinoma

Sources:
⁸Disease Ontology, ³²MalaCards
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Disease Ontology:⁸ A renal cell carcinoma that is the most common type of renal cell carcinoma. the cancerous cells appear very pale or clear when examined under microscope. this cancer can be effectively treated with surgery if the tumor is confined to the kidney.

MalaCards: Renal Clear Cell Carcinoma, also known as conventional renal cell carcinoma, is related to colon adenocarcinoma and von hippel-lindau disease. An important gene associated with Renal Clear Cell Carcinoma is MITF (microphthalmia-associated transcription factor), and among its related pathways are Hypoxic and oxygen homeostasis regulation of HIF-1-alpha and Cellular response to hypoxia. The compounds estrogen and fumarate have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and thyroid, and related mouse phenotypes are normal and homeostasis/metabolism.

Aliases & Classifications for Renal Clear Cell Carcinoma

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁴⁸Orphanet, ³⁴MeSH, ³⁹NCIt, ⁵⁶SNOMED-CT, ⁵⁷SNOMED-CT via Orphanet, ²⁶ICD10 via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases

ICD10: ²⁶

Neoplasms

Malignant neoplasms of urinary tract

Malignant neoplasm of kidney, except renal pelvis

Aliases & Descriptions:

renal clear cell carcinoma ⁸ ¹⁰ ⁴⁴

conventional renal cell carcinoma ⁸ ⁶⁰

clear cell renal cell adenocarcinoma ⁴⁸

conventional renal cell carcinoma ⁸

clear cell renal cell carcinoma ⁴⁸

clear cell carcinoma of kidney ⁸

clear cell renal carcinoma ⁴⁸

adenocarcinoma, clear cell ⁶⁰

clear cell adenocarcinoma ⁴⁸

ccrcc ⁴⁸

External Ids:

Disease Ontology⁸ DOID:4467

MeSH³⁴ D002292, C538445

NCIt³⁹ C4033

SNOMED-CT⁵⁶ 41607009, 254915003, 188251003

SNOMED-CT via Orphanet⁵⁷ 254915003

ICD10 via Orphanet²⁶ C64

UMLS⁶⁰ C0279702

Related Diseases for Renal Clear Cell Carcinoma

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Renal Cell Carcinoma family:

renal clear cell carcinoma	Familial Renal Cell Carcinoma
Renal Cell Carcinoma 4

Diseases related to Renal Clear Cell Carcinoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 199)

id	Related Disease	Score	Top Affiliating Genes
1	colon adenocarcinoma	30.8	POLR2L
2	von hippel-lindau disease	30.8	VHL, INHA, RASSF1, TCEB2
3	angiomyolipoma	30.7	MITF, S100A1
4	adenoma	30.7	VHL, AMACR, S100A1, MUC3A, INHA, RASSF1
5	nephrogenic adenoma	30.6	AMACR, S100A1, KRT7
6	ovarian cancer	30.6	VHL, INHA, CXCR3, RASSF1, KRT7
7	hepatitis	30.6	AMACR
8	adenocarcinoma	30.4	VHL, AMACR, CA9, MUC3A, EPOR, CLDN7
9	cystadenoma	30.3	VHL, INHA, KRT7
10	meningioma	30.3	S100A1, INHA
11	paraganglioma	30.3	FH, S100A1, VHL
12	chordoma	30.3	S100A1, INHA, KRT7
13	bladder carcinoma	30.3	FH, RASSF1, GSN
14	cystic kidney	30.3	FH, VHL
15	melanoma	30.3	AMACR, CA9, S100A1, MITF, EPOR, INHA
16	lung adenocarcinoma	30.3	AMACR, MUC3A, RASSF1, KRT7
17	squamous cell carcinoma	30.3	VHL, AMACR, CA9, S100A1, DEFB1, EPOR
18	hemangioblastoma	30.2	INHA, EPOR, VHL
19	pheochromocytoma	30.2	VHL, FH, EPOR, INHA
20	lung cancer	30.2	VHL, AMACR, CA9, S100A1, MUC3A, CXCR3
21	papillary carcinoma	30.2	AMACR, S100A1, KRT7
22	renal oncocytoma	30.2	PVALB, S100A1, CDH16, KRT7
23	kidney cancer	30.2	KRT7, TCEB2, CDH16, FH, CA9, AMACR
24	retinoblastoma	30.2	PVALB, VHL, POLR2L, MITF, RASSF1
25	endometrial carcinoma	30.1	CA9, INHA, RASSF1, KRT7
26	gastric adenocarcinoma	30.1	EPOR, CLDN7, KRT7
27	renal cell carcinoma	11.2
28	ovarian clear cell adenocarcinoma	11.1
29	urethra clear cell adenocarcinoma	10.8
30	ovary adenocarcinoma	10.8
31	vaginitis	10.8
32	urethra adenocarcinoma	10.8
33	bladder clear cell adenocarcinoma	10.8
34	endometriosis	10.8
35	bladder adenocarcinoma	10.7
36	thyroiditis	10.7
37	multilocular clear cell renal cell carcinoma	10.7
38	endometrial clear cell adenocarcinoma	10.7
39	urethritis	10.6
40	endometrial adenocarcinoma	10.6
41	adrenal carcinoma	10.6
42	cervical clear cell adenocarcinoma	10.6
43	urethral diverticulum	10.5
44	cervical adenocarcinoma	10.5
45	cervicitis	10.5
46	obesity	10.5
47	clear cell adenoma	10.5
48	fallopian tube clear cell adenocarcinoma	10.4
49	hereditary conventional renal cell carcinoma	10.4
50	small cell carcinoma	10.4

Graphical network of the top 20 diseases related to Renal Clear Cell Carcinoma:

Clinical Features for Renal Clear Cell Carcinoma

Drugs & Therapeutics for Renal Clear Cell Carcinoma

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Renal Clear Cell Carcinoma

Drug clinical trials:

Search ClinicalTrials for Renal Clear Cell Carcinoma

Search NIH Clinical Center for Renal Clear Cell Carcinoma

Search CenterWatch for Renal Clear Cell Carcinoma

Genetic Tests for Renal Clear Cell Carcinoma

Anatomical Context for Renal Clear Cell Carcinoma

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Renal Clear Cell Carcinoma:

³²

Kidney, Endothelial, Thyroid, T cells, Bone, Breast, Tongue, Lung, Pancreas, Lymph node, Brain, Prostate, Ovary, Colon, Adrenal gland, Salivary gland, Smooth muscle, Liver, Pituitary

Animal Models for Renal Clear Cell Carcinoma or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Renal Clear Cell Carcinoma:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	normal phenotype	MP:0002873	10.3	VHL, S100A1, MITF, EPOR, INHA, CXCR3
2	homeostasis/metabolism phenotype	MP:0005376	10.3	AMACR, FH, MITF, CXCR3, AQP2, GSN
3	mortality/aging	MP:0010768	10.3	GSN, VHL, AMACR, CA9, FH, DEFB1
4	renal/urinary system phenotype	MP:0005367	10.1	VHL, FH, DEFB1, CLDN7, CXCR3, KRT7

Publications for Renal Clear Cell Carcinoma

Sources:
⁵⁰PubMed
See all sources

Articles related to Renal Clear Cell Carcinoma:

(show top 50) (show all 788)

id	Title	Authors	Year
1	Targeted next-generation sequencing and non-coding RNA expression analysis of clear cell papillary renal cell carcinoma suggests distinct pathological mechanisms from other renal tumour subtypes. (24155122)	Lawrie C.H.... LA^pez J.I.	2014
2	Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma. (24387233)	Sonpavde G.... Sudarshan S.	2014
3	Clinical and pathological impact of VHL, PBRM1, BAP1, SETD2, KDM6A, and JARID1c in clear cell renal cell carcinoma. (24166983)	Gossage L.... Eisen T.	2014
4	Effects of TGF-I^ signaling in clear cell renal cell carcinoma cells. (23618868)	BostrAPm A.K.... Axelson H.	2013
5	Enhancer of zeste homolog 2 expression is associated with metastasis and adverse clinical outcome in clear cell renal cell carcinoma: a comparative study and review of the literature. (24079759)	Xu B.... Brimo F.	2013
6	Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma. (24382589)	Joseph R.W.... Parker A.	2013
7	Concurrent primary carcinoid tumor arising within mature teratoma and clear cell renal cell carcinoma in the horseshoe kidney: report of a rare case and review of the literature. (24228123)	Sun K.... Wang L.	2013
8	Clear cell renal cell carcinoma: discrimination from other renal cell carcinoma subtypes and oncocytoma at multiphasic multidetector CT. (23382290)	Young J.R.... Raman S.S.	2013
9	Cumulative number of altered biomarkers in mammalian target of rapamycin pathway is an independent predictor of outcome in patients with clear cell renal cell carcinoma. (23290145)	Darwish O.M.... Margulis V.	2013
10	Ki67 is an independent predictor of oncological outcomes in patients with localized clear-cell renal cell carcinoma. (23937277)	Gayed B.A.... Margulis V.	2013
11	The role of aberrant VHL/HIF pathway elements in predicting clinical outcome to pazopanib therapy in patients with metastatic clear-cell renal cell carcinoma. (23881929)	Choueiri T.K.... Signoretti S.	2013
12	Alterations of the WNT7A gene in clear cell renal cell carcinomas. (23056560)	Kondratov A.G.... Kashuba V.I.	2012
13	Expression of BNIP3 and its correlations to HIF-1alpha and VEGF in clear cell renal cell carcinoma]. (22455137)	Luo L.... Li X.	2012
14	CD31, EDNRB and TSPAN7 are promising prognostic markers in clear-cell renal cell carcinoma revealed by genome-wide expression analyses of primary tumors and metastases. (22213152)	Wuttig D.... Wirth M.P.	2012
15	Re: A. Rose Brannon, Scott M. Haake, Kathryn E. Hacker, et al. Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. Eur Urol 2012;61:258-68. (22790289)	Williamson S.R.... Grignon D.J.	2012
16	VHL-regulated MiR-204 suppresses tumor growth through inhibition of LC3B-mediated autophagy in renal clear cell carcinoma. (22516261)	Mikhaylova O.... Czyzyk-Krzeska M.F.	2012
17	Coexistence of renal epithelioid angiomyolipoma and clear cell carcinoma in patients without tuberous sclerosis. (21742645)	Cao Q.H.... Li Z.	2012
18	Association of RASSF1A genotype and haplotype with the progression of clear cell renal cell carcinoma in Japanese patients. (22520501)	Kawai Y.... Hinoda Y.	2012
19	CD31 angiogenesis and combined expression of HIF-1I+ and HIF-2I+ are prognostic in primary clear-cell renal cell carcinoma (CC-RCC), but HIFI+ transcriptional products are not: implications for antiangiogenic trials and HIFI+ biomarker studies in primary CC-RCC. (22777959)	Biswas S.... Harris A.L.	2012
20	Angiomyolipoma with minimal fat: can it be differentiated from clear cell renal cell carcinoma by using standard MR techniques? (23012463)	Hindman N.... Pedrosa I.	2012
21	Carbonic anhydrase IX is expressed in mesothelioma and metastatic clear cell renal cell carcinoma of the lung. (22143934)	Ramsey M.L.... Zynger D.L.	2012
22	The expression and clinical significance of Annexin II in clear-cell renal cell carcinoma]. (22230505)	Yang J.... Li X.	2012
23	Clinical, molecular, and genetic correlates of lymphatic spread in clear cell renal cell carcinoma. (22269604)	Kroeger N.... Pantuck A.J.	2012
24	Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. (22030119)	Brannon A.R.... Rathmell W.K.	2012
25	Time to recurrence after nephrectomy as a predictor of cancer-specific survival in localized clear-cell renal cell carcinoma. (20814191)	Rodriguez-Covarrubias F.... Feria-Bernal G.	2011
26	The neutrophil gelatinase-associated lipocalin, or LCN 2, marker of aggressiveness in clear cell renal cell carcinoma]. (22035911)	Perrin C.... Vigneau C.	2011
27	Impact of postoperative C-reactive protein level on recurrence and prognosis in patients with N0M0 clear cell renal cell carcinoma. (21679988)	Ito K.... Asano T.	2011
28	The distinction of clear cell carcinoma of the female genital tract, clear cell renal cell carcinoma, and translocation-associated renal cell carcinoma: an immunohistochemical study using tissue microarray. (21804394)	He H.... Chen L.	2011
29	Epigenetic inactivation of HOXA5 and MSH2 gene in clear cell renal cell carcinoma. (20846263)	Yoo K.H.... Chang S.G.	2010
30	Prognostic significance of Gremlin1 (GREM1) promoter CpG island hypermethylation in clear cell renal cell carcinoma. (20042676)	van Vlodrop I.J.... van Engeland M.	2010
31	Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment. (20709527)	Tostain J.... Gigante M.	2010
32	The use of immunohistochemistry in the diagnosis of metastatic clear cell renal cell carcinoma: a review of PAX-8, PAX-2, hKIM-1, RCCma, and CD10. (20966644)	Sangoi A.R.... McKenney J.K.	2010
33	External validation of the Mayo Clinic stage, size, grade, and necrosis (SSIGN) score for clear-cell renal cell carcinoma in a single European centre applying routine pathology. (19062157)	Zigeuner R.... Pummer K.	2010
34	Complexity of tumor vasculature in clear cell renal cell carcinoma. (19402071)	Qian C.N.... Teh B.T.	2009
35	The expression of thrombospondin-1 and p53 in clear cell renal cell carcinoma: its relationship to angiogenesis, cell proliferation and cancer specific survival. (19758660)	Zubac D.P.... Haukaas S.A.	2009
36	High expression of Ran GTPase is associated with local invasion and metastasis of human clear cell renal cell carcinoma. (18241036)	Abe H.... Yoshida K.	2008
37	Association of abnormal preoperative laboratory values with survival after radical nephrectomy for clinically confined clear cell renal cell carcinoma. (18308103)	Magera J.S.... Blute M.L.	2008
38	Computational pathology analysis of tissue microarrays predicts survival of renal clear cell carcinoma patients. (18982583)	Fuchs T.J.... Buhmann J.M.	2008
39	Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. (18496143)	Weinbreck N.... Vignaud J.M.	2008
40	Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. (16985214)	Varona A.... Larrinaga G.	2007
41	Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique. (16979727)	Zigeuner R.... Langner C.	2006
42	Sorafenib: scientific rationales for single-agent and combination therapy in clear-cell renal cell carcinoma. (16425993)	Gollob J.A.	2005
43	Intradural spinal metastasis of renal clear cell carcinoma causing cauda equina syndrome. (15254809)	Gaetani P.... Rodriguez y Baena R.	2004
44	Pathologic T1 clear cell renal cell carcinoma: insulin-like growth factor-I receptor expression and disease-specific survival. (15197799)	Parker A.S.... Cerhan J.R.	2004
45	Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. (12576453)	Bui M.H.... Belldegrun A.S.	2003
46	Gamna-Gandy nodules in a renal clear cell carcinoma. (12653589)	Leroy X.... Gosselin B.	2003
47	Pheochromocytoma and clear-cell renal carcinoma in a child with von Hippel-Lindau disease: a patient report. (10417977)	Ferragut J.... Alonso F.	1999
48	Renal clear cell carcinoma appearing as a left neck mass. (8870369)	Boggess M.A.... Archer S.M.	1996
49	Metastatic renal clear cell carcinoma in the thyroid gland diagnosed by fine needle aspiration cytology. (1878525)	Rikabi A.C.... Wilson C.	1991
50	A thyroid metastasis revealing an occult renal clear-cell carcinoma. (3554676)	Dal Fabbro S.... Barbazza R.	1987

Genes related to Renal Clear Cell Carcinoma

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc., ⁴⁸Orphanet
See all sources

Genes related to Renal Clear Cell Carcinoma:

(show top 50) (show all 92)

id	Symbol	Description	Score	Implication
1	MITF	microphthalmia-associated transcription factor	20.11	Susceptibility factor ⁴⁸ GeneCards inferred : Disorders (show sections)
2	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	19.90	GeneCards inferred : Publications, Disorders (show sections)
3	MUC3A	mucin 3A, cell surface associated	19.68	GeneCards inferred : Publications, Disorders (show sections)
4	AQP2	aquaporin 2 (collecting duct)	19.46	GeneCards inferred : Disorders (show sections)
5	DEFB1	defensin, beta 1	19.24	GeneCards inferred : Disorders (show sections)
6	EPOR	erythropoietin receptor	19.03	GeneCards inferred : Disorders (show sections)
7	FH	fumarate hydratase	18.81	GeneCards inferred : Disorders (show sections)
8	CXCR3	chemokine (C-X-C motif) receptor 3	18.59	GeneCards inferred : Disorders (show sections)
9	INHA	inhibin, alpha	18.37	GeneCards inferred : Disorders (show sections)
10	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	18.16	GeneCards inferred : Disorders (show sections)
11	AMACR	alpha-methylacyl-CoA racemase	17.94	GeneCards inferred : Disorders (show sections)
12	GSN	gelsolin	17.72	GeneCards inferred : Publications, Disorders (show sections)
13	CDH16	cadherin 16, KSP-cadherin	17.50	GeneCards inferred : Disorders (show sections)
14	TCEB2	transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)	17.29	GeneCards inferred : Publications, Disorders (show sections)
15	CLDN7	claudin 7	17.07	GeneCards inferred : Disorders (show sections)
16	CA9	carbonic anhydrase IX	16.85	GeneCards inferred : Publications, Disorders (show sections)
17	S100A1	S100 calcium binding protein A1	16.63	GeneCards inferred : Disorders (show sections)
18	PVALB	parvalbumin	16.42	GeneCards inferred : Disorders (show sections)
19	KRT7	keratin 7	16.20	GeneCards inferred : Publications, Disorders (show sections)
20	POLR2L	polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa	15.98	GeneCards inferred : Disorders (show sections)
21	CALB2	calbindin 2	15.76	GeneCards inferred : Disorders (show sections)
22	MME	membrane metallo-endopeptidase	15.55	GeneCards inferred : Publications, Disorders (show sections)
23	BIRC5	baculoviral IAP repeat containing 5	15.33	GeneCards inferred : Publications, Disorders (show sections)
24	FOLH1	folate hydrolase (prostate-specific membrane antigen) 1	15.11	GeneCards inferred : Disorders (show sections)
25	MUC1	mucin 1, cell surface associated	14.90	GeneCards inferred : Publications, Disorders (show sections)
26	SETD2	SET domain containing 2	14.68	GeneCards inferred : Disorders (show sections)
27	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	14.46	GeneCards inferred : Publications, Disorders (show sections)
28	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	14.24	GeneCards inferred : Disorders (show sections)
29	TGFBR2	transforming growth factor, beta receptor II (70/80kDa)	14.03	GeneCards inferred : Disorders (show sections)
30	MET	met proto-oncogene	13.81	GeneCards inferred : Disorders (show sections)
31	CASP8	caspase 8, apoptosis-related cysteine peptidase	13.59	GeneCards inferred : Disorders (show sections)
32	CAV1	caveolin 1, caveolae protein, 22kDa	13.37	GeneCards inferred : Disorders (show sections)
33	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	13.16	GeneCards inferred : Disorders (show sections)
34	TGFA	transforming growth factor, alpha	12.94	GeneCards inferred : Disorders (show sections)
35	VIM	vimentin	12.72	GeneCards inferred : Publications, Disorders (show sections)
36	MTOR	mechanistic target of rapamycin (serine/threonine kinase)	12.50	GeneCards inferred : Publications, Disorders (show sections)
37	CDH1	cadherin 1, type 1, E-cadherin (epithelial)	12.29	GeneCards inferred : Disorders (show sections)
38	PTEN	phosphatase and tensin homolog	12.07	GeneCards inferred : Disorders (show sections)
39	IGFBP3	insulin-like growth factor binding protein 3	11.85	GeneCards inferred : Disorders (show sections)
40	IGF1R	insulin-like growth factor 1 receptor	11.63	GeneCards inferred : Disorders (show sections)
41	VEGFA	vascular endothelial growth factor A	11.42	GeneCards inferred : Publications, Disorders (show sections)
42	FHIT	fragile histidine triad	11.20	GeneCards inferred : Disorders (show sections)
43	MIR204	microRNA 204	10.98	GeneCards inferred : Publications, Disorders (show sections)
44	RHEBL1	Ras homolog enriched in brain like 1	10.76	GeneCards inferred : Publications, Disorders (show sections)
45	TMEM115	transmembrane protein 115	10.54	GeneCards inferred : Publications, Disorders (show sections)
46	CADM4	cell adhesion molecule 4	10.32	GeneCards inferred : Publications, Disorders (show sections)
47	EGLN2	egl-9 family hypoxia-inducible factor 2	10.11	GeneCards inferred : Publications, Disorders (show sections)
48	KLF10	Kruppel-like factor 10	9.89	GeneCards inferred : Publications, Disorders (show sections)
49	THRA	thyroid hormone receptor, alpha	9.67	GeneCards inferred : Publications, Disorders (show sections)
50	CYP24A1	cytochrome P450, family 24, subfamily A, polypeptide 1	9.45	GeneCards inferred : Publications, Disorders (show sections)

Products for genes related to Renal Clear Cell Carcinoma disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	47	47	47
2	LSBio	-	-	50

Genetic Variations for Renal Clear Cell Carcinoma

Expression for genes affiliated with Renal Clear Cell Carcinoma

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Renal Clear Cell Carcinoma

Search GEO for disease gene expression data for Renal Clear Cell Carcinoma.

Pathways for genes affiliated with Renal Clear Cell Carcinoma

Sources:
³⁷NCBI BioSystems Database, ⁵³Reactome, ⁴Cell Signaling Technology, ²⁹KEGG
See all sources

Pathways related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha³⁷	10.4	TCEB2, VHL
2	Cellular response to hypoxia⁵³ Hide members Regulation of Gene Expression by Hypoxia-inducible Factor⁵³ Cellular responses to stress⁵³ Regulation of Hypoxia-inducible Factor (HIF) by Oxygen⁵³ Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha⁵³	10.4	VHL, CA9, TCEB2
3	Glucose / Energy Metabolism⁴	10.4	AQP2, FH, AMACR, CA9
4	Pathways in cancer²⁹	10.4	TCEB2, VHL, FH, MITF, RASSF1

Compounds for genes affiliated with Renal Clear Cell Carcinoma

Sources:
⁴⁴Novoseek, ¹¹DrugBank, ²⁴HMDB, ⁵⁹Tocris Bioscience, ²⁸IUPHAR, ⁴⁹PharmGKB, ²BitterDB
See all sources

Compounds related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

(show all 32)

id	Compound	Score	Top Affiliating Genes
1	estrogen⁴⁴	10.8	PVALB
2	fumarate⁴⁴ ¹¹	11.8	FH, AMACR, VHL
3	hematoxylin⁴⁴	10.7	AMACR, S100A1, INHA, KRT7
4	biotin⁴⁴ ¹¹ ²⁴	12.7	AQP2, INHA, S100A1, AMACR
5	streptavidin⁴⁴	10.7	KRT7, EPOR, AMACR
6	5-aza-2deoxycytidine⁴⁴	10.7	VHL, CA9, POLR2L, RASSF1, KRT7
7	methionine⁴⁴	10.7	PVALB, AMACR, RASSF1, AQP2, GSN
8	glucose⁴⁴	10.7	AMACR, CA9, DEFB1, TCEB2, KRT7, AQP2
9	oligonucleotide⁴⁴	10.7	VHL, AMACR, POLR2L, MITF, MUC3A, EPOR
10	paraffin⁴⁴	10.7	PVALB, AMACR, CA9, S100A1, MITF, EPOR
11	progesterone⁴⁴ ⁵⁹ ²⁸ ¹¹ ²⁴	14.7	AMACR, CA9, S100A1, MUC3A, INHA, CXCR3
12	oxygen⁴⁴ ²⁴	11.7	VHL, CA9, FH, MITF, EPOR, CXCR3
13	steroid⁴⁴	10.7	MUC3A, EPOR, INHA, CXCR3, AQP2, GSN
14	vegf⁴⁴	10.7	VHL, CA9, POLR2L, EPOR, CXCR3, TCEB2
15	proline⁴⁴	10.7	VHL, CA9, FH, POLR2L, EPOR
16	calcium⁴⁴ ⁴⁹ ¹¹ ²⁴	13.6	S100A1, CA9, AMACR, VHL, PVALB, MITF
17	iron⁴⁴ ²⁴	11.6	PVALB, VHL, S100A1, EPOR, KRT7
18	tyrosine⁴⁴	10.6	S100A1, CA9, AMACR, VHL, PVALB, FH
19	hydrogen⁴⁴ ²⁴	11.6	CA9, S100A1, FH, INHA, AQP2
20	retinoic acid⁴⁴ ²⁴	11.6	AMACR, S100A1, DEFB1, POLR2L, RASSF1, KRT7
21	serine⁴⁴	10.6	PVALB, VHL, POLR2L, EPOR, CXCR3, RASSF1
22	pimonidazole⁴⁴	10.6	EPOR, CA9
23	chloride⁴⁴	10.6	PVALB, AMACR, CA9, AQP2
24	arginine⁴⁴	10.6	POLR2L, MITF, EPOR, CXCR3, KRT7, AQP2
25	nitric oxide⁴⁴ ¹¹ ²⁴	12.6	PVALB, VHL, S100A1, EPOR, CXCR3, AQP2
26	silver⁴⁴	10.6	PVALB, S100A1, MITF
27	nad+⁴⁴	10.5	INHA, FH, PVALB
28	cysteine⁴⁴	10.5	AMACR, S100A1, POLR2L, EPOR, AQP2, GSN
29	glycogen⁴⁴ ²⁴	11.4	VHL, S100A1, KRT7, GSN
30	testosterone⁴⁴ ⁵⁹ ¹¹ ²⁴	13.4	AMACR, POLR2L, INHA, KRT7, GSN
31	azathioprine⁴⁴ ⁴⁹ ² ¹¹	13.3	GSN, RASSF1, POLR2L
32	mucicarmine⁴⁴	10.1	KRT7, S100A1

GO Terms for genes affiliated with Renal Clear Cell Carcinoma

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein complex	GO:043234	10.4	GSN, AQP2, MITF, S100A1

Biological processes related to Renal Clear Cell Carcinoma according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to hypoxia	GO:071456	10.4	TCEB2, CA9, VHL
2	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.1	TCEB2, CA9, VHL