MCID: RNL078
MIFTS: 37

Renal Dysplasia malady

Nephrological diseases, Fetal diseases categories

Summaries for Renal Dysplasia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Multicystic dysplastic kidney (MCDK) is a condition that results from the malformation of the kidney... more...

MalaCards: Renal Dysplasia is related to renal agenesis and vesicoureteral reflux. An important gene associated with Renal Dysplasia is GATA3 (GATA binding protein 3), and among its related pathways is Pathways in cancer. The compounds wortmannin and tgf beta1 have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Renal Dysplasia

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal dysplasia 48


External Ids:

ICD10 via Orphanet26 Q61.4

Related Diseases for Renal Dysplasia

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17GeneCards, 18GeneDecks
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Diseases in the Chronic Kidney Failure family:

Acute Kidney Failure Kidney Disease
Renal Infectious Disease Ren-Related Kidney Disease
renal dysplasia

Diseases related to Renal Dysplasia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 187)
idRelated DiseaseScoreTop Affiliating Genes
1renal agenesis30.5LHX1, SALL1, GDNF, RET
2vesicoureteral reflux30.0UMOD
3adenoma30.0MMP7, RET, GDNF
4urinary tract obstruction29.8GDNF, UMOD
5adenocarcinoma29.8MMP7, USF2, BMP2, PDGFA, HNF1B
6cystic kidney29.8UMOD, HNF1B
7hypoparathyroidism10.5
8multicystic renal dysplasia, bilateral10.4
9torticollis keloids cryptorchidism renal dysplasia10.3
10renal dysplasia-limb defects syndrome10.3
11urethritis10.3
12situs inversus10.3
13vaginitis10.2
14renal dysplasia, retinal pigmentary dystrophy, cerebellar ataxia and skeletal dysplasia10.2
15renal dysplasia, cystic10.2
16renal wilms' tumor10.2
17polydactyly10.2
18hypertension10.2
19pancreatitis10.2
20renal hypertension10.2
21renal dysplasia diffuse cystic10.2
22bilateral renal dysplasia10.2
23ureteral obstruction10.1
24hydronephrosis10.1
25senior-loken syndrome10.1
26ureterocele10.1
27hepatitis10.1
28pyelonephritis10.1
29barakat syndrome10.1
30selig benacerraf greene syndrome10.1
31senior-loken syndrome 110.1
32unilateral renal dysplasia10.1
33unilateral multicystic renal dysplasia10.1
34vacterl association10.0
35smith-lemli-opitz syndrome10.0
36cryptorchidism10.0
37urethral syndrome10.0
38digeorge syndrome10.0
39esophageal atresia10.0
40imperforate anus10.0
41hypercalcemia10.0
42cystic teratoma10.0
43esophagitis10.0
44mature teratoma10.0
45nephroblastoma10.0
46nephrotic syndrome10.0
47oligohydramnios10.0
48renal adenoma10.0
49retinitis10.0
50congenital hepatic fibrosis10.0

Graphical network of the top 20 diseases related to Renal Dysplasia:



Diseases related to renal dysplasia

Clinical Features for Renal Dysplasia

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Drugs & Therapeutics for Renal Dysplasia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Renal Dysplasia

Drug clinical trials:

Search ClinicalTrials for Renal Dysplasia

Search NIH Clinical Center for Renal Dysplasia

Search CenterWatch for Renal Dysplasia

Genetic Tests for Renal Dysplasia

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Anatomical Context for Renal Dysplasia

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32MalaCards
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MalaCards organs/tissues related to Renal Dysplasia:

32
Kidney

Animal Models for Renal Dysplasia or affiliated genes

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36MGI
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Publications for Renal Dysplasia

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Genetic Variations for Renal Dysplasia

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Expression for genes affiliated with Renal Dysplasia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Dysplasia

Search GEO for disease gene expression data for Renal Dysplasia.

Pathways for genes affiliated with Renal Dysplasia

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29KEGG
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Pathways related to Renal Dysplasia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9RET, SHH, BMP2, PDGFA

Compounds for genes affiliated with Renal Dysplasia

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44Novoseek, 24HMDB
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Compounds related to Renal Dysplasia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1wortmannin449.9MST1R, BMP2, GDNF, RET
2tgf beta1449.8BMP2, GATA3, GDNF, PDGFA
3pd 98,059449.8RET, GDNF, PDGFA, BMP2, MST1R
4zinc44 2410.6KRBOX4, SALL1, LMX1B, MMP7, GDNF, GATA3
5retinoic acid44 2410.6HNF1B, MMP7, RET, GDNF, GATA3, BMP2
6ribonucleic acid449.5RET, BMP2, PDGFA, MMP7
7oligonucleotide449.5KRBOX4, MMP7, RET, GDNF, GATA3, BMP2
8glucose449.4MMP7, GDNF, USF2, CPT2, UMOD, BMP2
9tyrosine449.3CPT2, MST1R, LMX1B, RET, GDNF, GATA3

GO Terms for genes affiliated with Renal Dysplasia

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16Gene Ontology
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Biological processes related to Renal Dysplasia according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1nephric duct morphogenesisGO:07217810.6LHX1, GATA3
2positive regulation of ureteric bud formationGO:07210710.6GDNF, GATA3
3ureteric bud formationGO:06067610.6GDNF, GATA3
4telencephalon regionalizationGO:02197810.6SHH, BMP2
5ureter maturationGO:03579910.5GATA3, RET
6anatomical structure formation involved in morphogenesisGO:04864610.5LHX1, GATA3
7pronephros developmentGO:04879310.5HNF1B, LHX1
8mesenchymal to epithelial transition involved in metanephros morphogenesisGO:00333710.5GDNF, SALL1
9uterus developmentGO:06006510.5LHX1, GATA3
10positive regulation of Wnt receptor signaling pathwayGO:03017710.5BMP2, SALL1, SHH
11dorsal/ventral pattern formationGO:00995310.5LHX1, SHH, LMX1B
12neural crest cell migrationGO:00175510.4RET, SHH, GDNF
13ventricular septum developmentGO:00328110.4SALL1, GATA3
14ureteric bud developmentGO:00165710.4RET, LHX1, SALL1
15inner ear developmentGO:04883910.4PDGFA, BMP2, SHH
16kidney developmentGO:00182210.4GATA3, HNF1B, LHX1, SALL1
17negative regulation of canonical Wnt receptor signaling pathwayGO:09009010.4BICC1, SHH, BMP2
18cellular response to BMP stimulusGO:07177310.4BMP2, GATA3
19anterior/posterior pattern specificationGO:00995210.3SHH, HNF1B, LHX1
20positive regulation of protein kinase B signaling cascadeGO:05189710.3PDGFA, GATA3, MST1R
21telencephalon developmentGO:02153710.3BMP2, LHX1
22branching involved in ureteric bud morphogenesisGO:00165810.2BMP2, GDNF, SHH, LHX1, SALL1
23embryo developmentGO:00979010.2BMP2, PDGFA, SHH
24positive regulation of branching involved in ureteric bud morphogenesisGO:09019010.2GDNF, LHX1
25organ morphogenesisGO:00988710.2BMP2, PDGFA, LHX1
26hindbrain developmentGO:03090210.1HNF1B, SHH
27cell-cell signalingGO:00726710.1PDGFA, BMP2, SHH, LHX1
28positive regulation of cell migrationGO:03033510.0RET, BMP2, PDGFA
29positive regulation of transcription, DNA-dependentGO:04589310.0SALL1, LHX1, HNF1B, GATA3, SHH, RET
30enteric nervous system developmentGO:0484849.9GDNF, RET
31positive regulation of transcription from RNA polymerase II promoterGO:0459449.8SHH, USF2, SALL1, GATA3, HNF1B, GDNF

Molecular functions related to Renal Dysplasia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:0469829.8USF2, BMP2, PDGFA, HNF1B
2sequence-specific DNA binding transcription factor activityGO:0037009.4LMX1B, HNF1B, LHX1, SALL1, GATA3, USF2

Products for genes affiliated with Renal Dysplasia

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  • Antibodies
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Sources for Renal Dysplasia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet