MCID: RNL113
MIFTS: 29

Renal Failure, Progressive, with Hypertension

Categories: Cardiovascular diseases, Genetic diseases, Ear diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Renal Failure, Progressive, with Hypertension

MalaCards integrated aliases for Renal Failure, Progressive, with Hypertension:

Name: Renal Failure, Progressive, with Hypertension 53 13 69
Autosomal Dominant Progressive Nephropathy with Hypertension 55
Nephritis, Familial, Without Deafness or Ocular Defect 53
Renal Failure, Adult-Onset; Aorf 53
Renal Failure, Adult-Onset 53
Hypertensive Nephropathy 69
Nephropathy-Hypertension 53
Nephropathy, Familial 53
Rfh1 53
Aorf 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant

Miscellaneous:
onset in young adulthood or adulthood
hypertension is presenting sign
progressive disorder
one family has been reported (last curated december 2012)


HPO:

31
renal failure, progressive, with hypertension:
Inheritance autosomal dominant inheritance
Onset and clinical course adult onset progressive


Classifications:



Summaries for Renal Failure, Progressive, with Hypertension

MalaCards based summary : Renal Failure, Progressive, with Hypertension, also known as autosomal dominant progressive nephropathy with hypertension, is related to hyperuricemic nephropathy, familial juvenile, 1 and hyperuricemic nephropathy, familial juvenile, 2, and has symptoms including hypertension, renal insufficiency and proteinuria. An important gene associated with Renal Failure, Progressive, with Hypertension is RFH1 (Renal Failure, Progressive, With Hypertension). Affiliated tissues include kidney.

Description from OMIM: 161900

Related Diseases for Renal Failure, Progressive, with Hypertension

Graphical network of the top 20 diseases related to Renal Failure, Progressive, with Hypertension:



Diseases related to Renal Failure, Progressive, with Hypertension

Symptoms & Phenotypes for Renal Failure, Progressive, with Hypertension

Symptoms via clinical synopsis from OMIM:

53
Cardiovascular Vascular:
hypertension

Laboratory Abnormalities:
increased serum creatinine
no proteinuria

Genitourinary Kidneys:
renal failure, progressive
end-stage renal disease
renal biopsy showed interstitial fibrosis
some sclerotic glomeruli
no complement deposition


Clinical features from OMIM:

161900

Human phenotypes related to Renal Failure, Progressive, with Hypertension:

31 (show all 7)
# Description HPO Frequency HPO Source Accession
1 hypertension 31 HP:0000822
2 renal insufficiency 31 HP:0000083
3 proteinuria 31 HP:0000093
4 elevated serum creatinine 31 HP:0003259
5 stage 5 chronic kidney disease 31 HP:0003774
6 microscopic hematuria 31 HP:0002907
7 nephritis 31 HP:0000123

Drugs & Therapeutics for Renal Failure, Progressive, with Hypertension

Search Clinical Trials , NIH Clinical Center for Renal Failure, Progressive, with Hypertension

Genetic Tests for Renal Failure, Progressive, with Hypertension

Anatomical Context for Renal Failure, Progressive, with Hypertension

MalaCards organs/tissues related to Renal Failure, Progressive, with Hypertension:

38
Kidney

Publications for Renal Failure, Progressive, with Hypertension

Articles related to Renal Failure, Progressive, with Hypertension:

(show all 44)
# Title Authors Year
1
Identification of potential biomarkers and therapeutic targets for human IgA nephropathy and hypertensive nephropathy by bioinformatics analysis. ( 28713898 )
2017
2
Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin Degradation. ( 28808068 )
2017
3
Hypertensive nephropathy. Moving from classic to emerging pathogenetic mechanisms. ( 27782909 )
2017
4
Adjunctive therapy with statins reduces residual albuminuria/proteinuria and provides further renoprotection by downregulating the angiotensin II-AT1 pathway in hypertensive nephropathy. ( 28244896 )
2017
5
An Analysis of Anthropometric Indicators and Modifiable Lifestyle Parameters Associated with Hypertensive Nephropathy. ( 27774313 )
2016
6
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27753857 )
2016
7
Sequential activation of the intrarenal renin-angiotensin system in the progression of hypertensive nephropathy in Goldblatt rats. ( 26823279 )
2016
8
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy. ( 27558173 )
2016
9
SP 01-1 ALDOSTERONE ANTAGONISTS FOR THE TREATMENT OF HYPERTENSIVE NEPHROPATHY. ( 27643094 )
2016
10
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27642978 )
2016
11
Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile. ( 27756246 )
2016
12
OS 15-06 SEQUENTIAL ACTIVATION OF INTRARENAL ACE/ACE2 AS THE PROGRESSION OF HYPERTENSIVE NEPHROPATHY IN 2-KIDNEY 10CLIP (2K1C) GOLDBLATT RATS. ( 27754058 )
2016
13
Extracorporeal shock wave therapy does not improve hypertensive nephropathy. ( 27255359 )
2016
14
Pharmacological inhibition of galectin-3 protects against hypertensive nephropathy. ( 25503732 )
2015
15
Characteristics of podocyte injury in malignant hypertensive nephropathy of rats (MSHRSP/Kpo strain). ( 26522148 )
2015
16
Conversion from calcineurin inhibitors to mTOR inhibitors stabilizes diabetic and hypertensive nephropathy after liver transplant. ( 25815268 )
2015
17
Protective effect of 3-n-butylphthalide against hypertensive nephropathy in spontaneously hypertensive rats. ( 25352064 )
2014
18
Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. ( 24368192 )
2014
19
Renoprotective activity of aliskiren, a renin inhibitor in cyclosporine A induced hypertensive nephropathy in dTG mice. ( 24905308 )
2014
20
Translational study of the Notch pathway in hypertensive nephropathy. ( 24798563 )
2014
21
Smad7 inhibits AngII-mediated hypertensive nephropathy in a mouse model of hypertension. ( 24511990 )
2014
22
Is it variants in the apolipoprotein l1 gene, or blood pressure control, that predicts progression of nondiabetic hypertensive nephropathy in African Americans? ( 23815529 )
2013
23
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats. ( 24029866 )
2013
24
Renal-protective effect of nicousamide on hypertensive nephropathy in spontaneously hypertensive rats. ( 24648890 )
2013
25
Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. ( 23192770 )
2013
26
Effects of meteorological elements on admission rates of cerebral infarction patients with hypertensive nephropathy from nine hospitals in Changchun city, Jilin Province. ( 23673113 )
2013
27
Increased renal iron accumulation in hypertensive nephropathy of salt-loaded hypertensive rats. ( 24116080 )
2013
28
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor. ( 24238127 )
2013
29
Clinical and pathological analysis of the kidney in patients with hypertensive nephropathy. ( 24223652 )
2013
30
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy. ( 22403621 )
2012
31
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats. ( 23102665 )
2012
32
Dietary acid reduction with fruits and vegetables or bicarbonate attenuates kidney injury in patients with a moderately reduced glomerular filtration rate due to hypertensive nephropathy. ( 21881553 )
2012
33
Hypertensive nephropathy in children - do we diagnose early enough? ( 22424480 )
2012
34
Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. ( 21475627 )
2011
35
Increased risk of cardiovascular events and mortality among non-diabetic chronic kidney disease patients with hypertensive nephropathy: the Gonryo study. ( 21796127 )
2011
36
Diabetic and hypertensive nephropathy in India. ( 21751620 )
2011
37
Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population. ( 21080079 )
2011
38
African American hypertensive nephropathy maps to a new locus on chromosome 9q31-q32. ( 12840782 )
2003
39
[Hypertensive nephropathy: a growing cause of renal insufficiency]. ( 11244820 )
2001
40
Role of plasma and urinary endothelin-1 in early diabetic and hypertensive nephropathy. ( 9715792 )
1998
41
The effects of isradipine and spirapril as monotherapy and combined therapy on blood pressure, renal hemodynamics, natriuresis, and urinary kallikrein in hypertensive nephropathy. ( 9160765 )
1997
42
Hypertensive nephropathy and the gene for angiotensin-converting enzyme. ( 9081678 )
1997
43
Predictors for hypertensive nephropathy: results of a 6-year follow-up study in essential hypertension. ( 7622857 )
1995
44
Impact of antihypertensive therapy with isradipine and metoprolol on early markers of hypertensive nephropathy. ( 1533771 )
1992

Variations for Renal Failure, Progressive, with Hypertension

Expression for Renal Failure, Progressive, with Hypertension

Search GEO for disease gene expression data for Renal Failure, Progressive, with Hypertension.

Pathways for Renal Failure, Progressive, with Hypertension

GO Terms for Renal Failure, Progressive, with Hypertension

Sources for Renal Failure, Progressive, with Hypertension

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