MCID: RNL077
MIFTS: 47

Renal Fibrosis malady

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

Aliases & Descriptions for Renal Fibrosis:

Name: Renal Fibrosis 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855

Summaries for Renal Fibrosis

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and anhidrosis. An important gene associated with Renal Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Mycophenolate mofetil and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Related Disease Score Top Affiliating Genes
1 ureteral obstruction 10.3
2 anhidrosis 10.3 BMP6 CTGF TGFB1
3 respiratory syncytial virus infectious disease 10.2 BMP6 ENG TGFB1
4 agammaglobulinemia 6 10.2 AGTR1 CTGF TGFB1
5 hereditary night blindness 10.2 BMP6 CTGF SMAD3 TGFB1
6 epididymis cancer 10.2 ENG TGFB1
7 benign secondary hypertension 10.2 CCL2 SERPINE1 TGFB1
8 uterine inflammatory disease 10.2 REN SERPINE1
9 zika fever 10.2 CD36 CTGF TGFB1
10 ulnar hemimelia 10.2 BMP7 CTGF SMAD2
11 flat umbilicus familial 10.2 AGTR1 REN TGFB1
12 vibratory urticaria 10.2 SMAD2 SMAD3 TGFB1
13 upper respiratory tract disease 10.2 CTGF SMAD2 TGFB1
14 agraphia 10.2 BMP6 CD36 CTGF
15 malignant neoplasm of acoustic nerve 10.2 CCL2 CTGF SERPINE1 TGFB1
16 lymphangiectasia, intestinal 10.1 CD36 CTGF TGFB1
17 germ cell and embryonal cancer 10.1 CD36 CTGF TGFB1
18 demyelinating polyneuropathy 10.1 AGTR1 BMP6 BMP7 TGFB1
19 prostate neuroendocrine neoplasm 10.1 AGTR1 NR3C2 REN
20 mass syndrome 10.1 AGTR1 BMP6 TGFB1
21 panuveitis 10.1 AGTR1 NR3C2 REN
22 lubani-al saleh-teebi syndrome 10.1 SMAD3 SMAD7 TGFB1
23 familial nasal acilia 10.1 AGTR1 NR3C2 REN
24 clear cell adenocarcinoma 10.1 AGTR1 NR3C2 REN
25 laryngostenosis 10.1 AGTR1 CD36 NR3C2
26 mixed germ cell-sex cord neoplasm 10.1 AGTR1 REN TGFB1
27 sydenham chorea 10.0 BMP6 ENG REN SERPINE1 TGFB1
28 hypertrichosis of eyelid 10.0 AGTR1 CCL2 CTGF NR3C2 TGFB1
29 calcinosis 10.0 AGTR1 CCL2 CTGF REN TGFB1
30 budd-chiari syndrome 10.0 AGTR1 BMP7 REN SERPINE1
31 welander distal myopathy 10.0 AGTR1 ENG SERPINE1
32 human venous malformation 10.0 BMP6 ENG TGFB1
33 pyrimidine metabolic disorder 10.0 AGTR1 CCL2 REN SERPINE1
34 speech and communication disorders 9.9 BMP6 CD36 SMAD2 SMAD3 TGFB1
35 albinism, oculocutaneous, type ia 9.9 CCL2 CTGF HGF TGFB1
36 epidermolysis bullosa simplex, sutosomal recessive 2 9.9 CCL2 CTGF HGF
37 kidney disease 9.9
38 patent foramen ovale 9.9 CTGF HGF TGFB1
39 lymphoblastic lymphoma 9.9 CTGF HGF REN TGFB1
40 neuroectodermal endocrine syndrome 9.9 CTGF SMAD2 SMAD3 SMAD7 TGFB1
41 albright's hereditary osteodystrophy 9.9 CD36 SMAD2 SMAD3 SMAD7
42 renal tubular acidosis 9.9 CCL2 CTGF HGF SMAD3 TGFB1
43 myocardial infarction 9.8 AGTR1 CCL2 NR3C2 REN SERPINE1 TGFB1
44 leber congenital amaurosis 9.8 CD36 SMAD2 SMAD3 SMAD7 TGFB1
45 ischemia 9.7
46 glomerulonephritis 9.7
47 endotheliitis 9.7
48 alport syndrome 9.6
49 hypoxia 9.6
50 pyelonephritis 9.6

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

MGI Mouse Phenotypes related to Renal Fibrosis:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.5 HGF MAPK8 NR3C2 REN RGCC SERPINE1
2 growth/size/body region MP:0005378 10.42 AGTR1 BMP6 BMP7 CD36 CDH1 CTGF
3 behavior/neurological MP:0005386 10.32 AGTR1 BMP7 CD36 ENG MAPK8 NR3C2
4 hematopoietic system MP:0005397 10.32 AGTR1 BMP7 CD36 ENG HGF MAPK8
5 cellular MP:0005384 10.3 CD36 CDH1 CTGF HGF MAPK8 NR3C2
6 embryo MP:0005380 10.3 BMP7 CDH1 CTGF ENG HGF MAPK8
7 homeostasis/metabolism MP:0005376 10.3 AGTR1 CD36 CDH1 CTGF ENG MAPK8
8 immune system MP:0005387 10.25 CDH1 MAPK8 REN SERPINE1 SMAD2 SMAD3
9 mortality/aging MP:0010768 10.25 BMP7 CD36 CDH1 CTGF ENG HGF
10 digestive/alimentary MP:0005381 10.24 BMP7 CD36 CDH1 CTGF ENG MAPK8
11 endocrine/exocrine gland MP:0005379 10.16 BMP7 CD36 CDH1 MAPK8 SMAD2 SMAD3
12 craniofacial MP:0005382 10.15 SMAD7 TGFB1 BMP7 CTGF ENG MAPK8
13 integument MP:0010771 10.1 BMP7 CDH1 CTGF ENG MAPK8 SERPINE1
14 liver/biliary system MP:0005370 9.91 SMAD3 TGFB1 CD36 HGF MAPK8 SERPINE1
15 nervous system MP:0003631 9.9 SMAD2 SMAD3 SPHK1 TGFB1 AGTR1 BMP7
16 muscle MP:0005369 9.86 CD36 ENG MAPK8 NR3C2 REN SMAD7
17 renal/urinary system MP:0005367 9.61 AGTR1 BMP7 CD36 MAPK8 NR3C2 REN
18 reproductive system MP:0005389 9.28 TGFB1 SMAD7 BMP6 BMP7 CDH1 MAPK8

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 432)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 128794-94-5 5281078
2
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1 24280-93-1 446541
3
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2 104987-11-3 445643 439492
4
Cyclosporine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 79217-60-0, 59865-13-3 5284373 6435893
5
Daclizumab Approved, Investigational Phase 4 152923-56-3
6
Everolimus Approved Phase 4,Phase 3,Phase 2 159351-69-6 6442177
7
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
8
Sirolimus Approved, Investigational Phase 4,Phase 3,Phase 2 53123-88-9 5284616 6436030 46835353
9
Procaine Approved, Investigational, Vet_approved Phase 4 59-46-1 4914
10
Spironolactone Approved Phase 4,Phase 3,Phase 2 1952-01-7, 52-01-7 5833
11
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
12
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
13
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
14
Febuxostat Approved Phase 4 144060-53-7 134018
15
Nitric Oxide Approved Phase 4,Phase 2,Phase 1 10102-43-9 145068
16
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
17
Lactulose Approved Phase 4 4618-18-2 11333
18
Rifaximin Approved, Investigational Phase 4 80621-81-4 6436173
19
Basiliximab Approved, Investigational Phase 4,Phase 3 152923-56-3, 179045-86-4
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3 83-43-2 6741
21
Prednisolone Approved, Vet_approved Phase 4,Phase 3 50-24-8 5755
22
Adefovir Dipivoxil Approved, Investigational Phase 4 142340-99-6 60871
23
Telbivudine Approved, Investigational Phase 4 3424-98-4 159269
24
Furosemide Approved, Vet_approved Phase 4,Phase 3,Phase 2 54-31-9 3440
25
Norfloxacin Approved Phase 4,Phase 3,Phase 2 70458-96-7 4539
26
Terlipressin Approved, Investigational Phase 4,Phase 2,Phase 3 14636-12-5 72081
27
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 1,Phase 2 723-46-6 5329
28
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 738-70-5 5578
29
rituximab Approved Phase 4,Phase 2,Phase 3 174722-31-7 10201696
30
Tobramycin Approved, Investigational Phase 4,Phase 3,Phase 2 32986-56-4 5496 36294
31
Benzocaine Approved Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
32
Fluvastatin Approved Phase 4 93957-54-1 1548972
33
Tazobactam Approved Phase 4 89786-04-9 123630
34
Ursodeoxycholic acid Approved, Investigational Phase 4,Phase 3 128-13-2 31401
35
Chlorthalidone Approved Phase 4 77-36-1 2732
36
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
37
Verapamil Approved Phase 4 52-53-9 2520
38
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2 147127-20-6 464205
39
Tranexamic Acid Approved Phase 4 1197-18-8 5526
40
Inulin Approved, Nutraceutical Phase 4 9005-80-5 24763
41
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 59-30-3 6037
42
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2 58-05-9 54575, 6560146 143
43 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 2
44
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
45
Uric Acid Experimental, Investigational Phase 4 69-93-2 1175
46
Pirfenidone Investigational Phase 4,Phase 3,Phase 2,Phase 1 53179-13-8 40632
47 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
49 Calcineurin Inhibitors Phase 4,Phase 3,Phase 2,Early Phase 1
50 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 386)
id Name Status NCT ID Phase
1 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4
2 Fibrosis in Renal Allografts Unknown status NCT00493194 Phase 4
3 Kidney Biopsy Controlled Trial of Calcineurin Inhibitor Withdrawal Unknown status NCT00896012 Phase 4
4 Tacrolimus to Sirolimus Conversion for Delayed Graft Function Unknown status NCT00931255 Phase 4
5 Mineralocorticoid Receptor Antagonist and Kidney Allograft Histology Unknown status NCT01510795 Phase 4
6 Prospective Study to Measure Vascular Parameters (Ancillary Study of ADEQUATE) Unknown status NCT02154854 Phase 4
7 Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal Transplant Unknown status NCT01239472 Phase 4
8 Anti-Oxidant Effect on Peritoneal Membrane in Peritoneal Dialysis (PD) Patients Unknown status NCT01111422 Phase 4
9 A Clinical Trial to Assess the Efficacy and Safety of the Conversion to Everolimus Unknown status NCT01608412 Phase 4
10 Evaluation of Early Use of Everolimus (EVE) on Cytomegalovirus (CMV) Infection in Renal Transplant Recipients Unknown status NCT01927588 Phase 4
11 Effects of Spironolactone in Dialysis Unknown status NCT01128101 Phase 4
12 The Effect of Uric Acid Lowering in Type 1 Diabetes Unknown status NCT02344602 Phase 4
13 Rifaximin Versus Lactulose in Renal Failure Unknown status NCT00748904 Phase 4
14 Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis (SBP) Unknown status NCT00761098 Phase 4
15 Steroid Free Immunosuppression or Calcineurin Inhibitor Minimization After Basiliximab Induction Therapy in Kidney Transplantation: Comparison With a Standard Quadruple Immunosuppressive Regimen Unknown status NCT01560572 Phase 4
16 Comparison the Level of CTGF Protein and Related Cytokine in Pleural Effusion Unknown status NCT00313066 Phase 4
17 Telbivudine Renoprotective Effect in Patients With the HBV-related Liver Cirrhosis: a Randomized Controlled Trial Unknown status NCT01799486 Phase 4
18 Proportion of CMV Seropositive Kidney Transplant Recipients Who Will Develop a CMV Infection When Treated With an Immunosuppressive Regimen Including Everolimus and Reduced Dose of Cyclosporineversus an Immunosuppressive Regimen With Mycophenolic Acid and Unknown status NCT02328963 Phase 4
19 Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion Unknown status NCT01353105 Phase 4
20 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4
21 Safety of Gadovist in Renally Impaired Patients Completed NCT00828737 Phase 4
22 Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Moderate Renal Insufficiency After the Administration of Magnevist Completed NCT00744939 Phase 4
23 Novartis Everolimus Transition Completed NCT02096107 Phase 4
24 Primovist / Eovist in Renally Impaired Patients Completed NCT00908596 Phase 4
25 A Study of the Impact of an Early Biopsy in Patients Treated With CellCept (Mycophenolate Mofetil) After Kidney Transplantation Completed NCT00817687 Phase 4
26 Circadian Rhythm In Tobramycin Elimination In Cystic Fibrosis Completed NCT01207245 Phase 4
27 Everolimus Rescue Immunosuppression in the Treatment of Chronic Allograft Dysfunction in Renal Transplant Recipients Completed NCT01046045 Phase 4
28 Post-marketing Safety Study in Patients With Moderate Renal Insufficiency Who Receive Omniscan for Contrast-enhanced Magnetic Resonance Imaging (MRI) Completed NCT00908310 Phase 4
29 Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant Completed NCT00188955 Phase 4
30 Benefit of Early Protocol Biopsy and Treatment of Subclinical Rejection Completed NCT00885820 Phase 4
31 Effect of An Oral Absorbent AST-120 in Late-stage Chronic Kidney Disease (CKD) Patients. Completed NCT01681303 Phase 4
32 Effect of a New Formulation of Torasemide (Prolonged Release)on Myocardial Fibrosis in Patients With Heart Failure. Completed NCT00409942 Phase 4
33 The Effects of Omega-3 Fatty Acids in Renal Transplantation Completed NCT01744067 Phase 4
34 Trial to Evaluate the Efficacy of Fluvastatin on Certain Markers Completed NCT00171262 Phase 4
35 Tacrolimus as Secondary Intervention vs. Continuation of Cyclosporine in Renal Transplant Patients With Chronic Renal Allograft Failure (CRAF) Completed NCT00637143 Phase 4
36 Clinical Trial on the Effects of Long Term Administration of 20% Albumin in the Cardiovascular and Renal Function, And Hepatic Hemodynamics in Advanced Patients With Cirrhosis and Ascites. Completed NCT00968695 Phase 4
37 Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients Completed NCT02421120 Phase 4
38 Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure" Completed NCT01201720 Phase 4
39 Intestinal Decontamination With Rifaximin. The Inflammatory and Circulatory State in Patients With Cirrhosis Completed NCT01769040 Phase 4
40 Prospective Study of Profile of Hepatic Osteodystrophy in Patients With Non-Choleastatic Liver Cirrhosis and Impact of Bisphosphonate Supplementation Completed NCT02249741 Phase 4
41 Norfloxacin In The Primary Prophylaxis Of Spontaneous Bacterial Peritonitis Completed NCT00359853 Phase 4
42 Human Albumin for the Treatment of Ascites in Patients With Hepatic Cirrhosis Completed NCT01288794 Phase 4
43 Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy Completed NCT02019784 Phase 4
44 Comparing the Effects of Spironolactone With Chlortalidone on LV Mass in Patients With CKD Recruiting NCT02502981 Phase 4
45 IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy Recruiting NCT02918409 Phase 4
46 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
47 Steroid Withdrawal and Donor-specific Anti-HLA Antibodies in Renal Transplant Patients Recruiting NCT02284464 Phase 4
48 Efficacy of Everolimus in Combination With Tacrolimus in Liver Transplant Recipients Recruiting NCT01551212 Phase 4
49 Feraheme As An MRI Contrast Agent For Pediatric Congenital Heart Disease Recruiting NCT02752191 Phase 4
50 A Clinical Study on the Efficacy and Safety of the Treatment of Hyperplasia of Mammary Glands With Xiaoru Sanjie Capsule Recruiting NCT02929420 Phase 4

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

39
Kidney, Bone, Endothelial, Myeloid, T Cells, Neutrophil, Monocytes

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 271)
id Title Authors Year
1
Klotho as a Therapeutic Target during the Development of Renal Fibrosis. ( 27951565 )
2017
2
H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-I^1 expression. ( 27882817 )
2017
3
Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models and Therapeutic Strategies. ( 28064215 )
2017
4
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. ( 27784694 )
2017
5
Therapeutic activity of the histone deacetylase inhibitor SB939 on renal fibrosis. ( 27855304 )
2017
6
PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. ( 28045076 )
2017
7
Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study. ( 28045061 )
2017
8
HuangQi Decoction Ameliorates Renal Fibrosis via TGF-I^/Smad Signaling Pathway In Vivo and In Vitro. ( 27161221 )
2016
9
Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation. ( 27165825 )
2016
10
The complement factor 5a receptor 1 has a pathogenic role in chronic inflammation and renal fibrosis in a murine model of chronic pyelonephritis. ( 27370410 )
2016
11
Angiotensin-converting enzyme 2 ameliorates renal fibrosis by blocking the activation of mTOR/ERK signaling in apolipoprotein E-deficient mice. ( 27018342 )
2016
12
Effect of Novel Gasotransmitter hydrogen sulfide on renal fibrosis and connexins expression in diabetic rats. ( 27575818 )
2016
13
Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension. ( 27986554 )
2016
14
Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog. ( 27140856 )
2016
15
Sorafenib Inhibits Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Inhibition of Macrophage Infiltration. ( 27744426 )
2016
16
Spirolactone provides protection from renal fibrosis by inhibiting the endothelial-mesenchymal transition in isoprenaline-induced heart failure in rats. ( 27217725 )
2016
17
Involvement of spliced X-box binding protein 1 in renal fibrosis induced by unilateral ureteral obstruction in mice. ( 27108902 )
2016
18
CD39 overexpression does not attenuate renal fibrosis in the unilateral ureteric obstructive model of chronic kidney disease. ( 27565966 )
2016
19
Hydrosoluble 50% N-acetylation-thiolated chitosan complex with cobalt as a pH-responsive renal fibrosis targeting drugs. ( 27115330 )
2016
20
Histone H2AK119 and H2BK120 Monoubiquitination Modulate SET7/9 and SUV39H1 in Type 1 Diabetes Induced Renal Fibrosis. ( 27582499 )
2016
21
Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice. ( 27509062 )
2016
22
Curcumin attenuates cyclosporine Aa89induced renal fibrosis by inhibiting hypermethylation of the klotho promoter. ( 27510836 )
2016
23
Renal Fibrosis mRNA Classifier: Validation in Experimental Lithium-Induced Interstitial Fibrosis in the Rat Kidney. ( 28002484 )
2016
24
Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. ( 27902771 )
2016
25
The Protective Effect of Melittin on Renal Fibrosis in an Animal Model of Unilateral Ureteral Obstruction. ( 27618890 )
2016
26
CD11ca8_ CD8a8_ T Cells Reduce Renal Fibrosis Following Ureteric Obstruction by Inducing Fibroblast Apoptosis. ( 28025478 )
2016
27
Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis. ( 27906172 )
2016
28
Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats. ( 27109518 )
2016
29
Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR. ( 26866372 )
2016
30
N-acetylcysteine alleviates angiotensin II-mediated renal fibrosis in mouse obstructed kidneys. ( 27041464 )
2016
31
Oxymatrine inhibits renal fibrosis of obstructive nephropathy by downregulating the TGF-I^1-Smad3 pathway. ( 27050799 )
2016
32
Activation of FXR protects against renal fibrosis via suppressing Smad3 expression. ( 27853248 )
2016
33
Fyn deficiency attenuates renal fibrosis by inhibition of phospho-STAT3. ( 27616741 )
2016
34
Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease. ( 27165838 )
2016
35
Genomic Analysis of Kidney Allograft Injury Identifies Hematopoietic Cell Kinase as a Key Driver of Renal Fibrosis. ( 27927780 )
2016
36
Exosomes from high glucose-treated glomerular endothelial cells activate mesangial cells to promote renal fibrosis. ( 27010029 )
2016
37
IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion:compensatory role of Natural Killer cells in athymic rats. ( 27852609 )
2016
38
Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGFI^ signaling. ( 27211841 )
2016
39
YIA 03-02 ADIPONECTIN-MEDIATED EPITHELIAL AUTOPHAGY ATTENUATES HYPERTENSIVE RENAL FIBROSIS. ( 27642944 )
2016
40
Reduced expression of VAChT increases renal fibrosis. ( 27524473 )
2016
41
Metformin Prevents Renal Fibrosis in Mice with Unilateral Ureteral Obstruction and Inhibits Ang II-Induced ECM Production in Renal Fibroblasts. ( 26805826 )
2016
42
Pentraxin 3 Activates JNK Signaling and Regulates the Epithelial-To-Mesenchymal Transition in Renal Fibrosis. ( 27941350 )
2016
43
Elucidation of the therapeutic role of mitochondrial biogenesis transducers NRF-1 in the regulation of renal fibrosis. ( 27634749 )
2016
44
Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction. ( 27321931 )
2016
45
Angiopoietin-like protein 2 increases renal fibrosis by accelerating transforming growth factor-I^ signaling in chronic kidney disease. ( 26806834 )
2016
46
Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases. ( 27189340 )
2016
47
TGF-I^1/Smads and miR-21 in Renal Fibrosis and Inflammation. ( 27610006 )
2016
48
Elevated serum concentrations of HE4 as a novel biomarker of disease severity and renal fibrosis in kidney disease. ( 27589683 )
2016
49
Peroxisome proliferator-activated receptor-I^ agonist pioglitazone fails to attenuate renal fibrosis caused by unilateral ureteral obstruction in mice. ( 26838738 )
2016
50
Protective role of activin receptor-like kinase 7 gene silencing in renal fibrosis. ( 27620491 )
2016

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.87 BMP6 BMP7 CCL2 CDH1 CTGF HGF
2
Show member pathways
13.53 AGTR1 BMP6 BMP7 CCL2 CDH1 CTGF
3
Show member pathways
13.32 BMP6 BMP7 CCL2 CDH1 CTGF HGF
4
Show member pathways
13.29 BMP6 BMP7 CDH1 CTGF HGF MAPK8
5
Show member pathways
13.07 AGTR1 BMP6 BMP7 CCL2 CTGF HGF
6
Show member pathways
12.92 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3 TGFB1
7 12.72 AGTR1 CDH1 HGF MAPK8 SMAD2 SMAD3
8
Show member pathways
12.7 BMP6 BMP7 CTGF HGF TGFB1
9
Show member pathways
12.57 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
10
Show member pathways
12.5 BMP7 SMAD2 SMAD3 SPHK1 TGFB1
11 12.42 MAPK8 SMAD2 SMAD3 TGFB1
12
Show member pathways
12.39 CDH1 MAPK8 SMAD2 SMAD3 TGFB1
13 12.37 CDH1 SMAD2 SMAD3 TGFB1
14
Show member pathways
12.34 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
15
Show member pathways
12.23 MAPK8 SMAD2 SMAD3 TGFB1
16 12.23 BMP6 BMP7 ENG SERPINE1 SMAD2 SMAD3
17 12.19 CDH1 SMAD2 SMAD3 TGFB1
18
Show member pathways
12.11 MAPK8 SMAD2 SMAD3 TGFB1
19 12.11 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
20
Show member pathways
12.1 MAPK8 SMAD2 SMAD3 TGFB1
21 12.05 AGTR1 CDH1 CTGF SERPINE1 SMAD2 SMAD3
22 12.01 CCL2 CD36 HGF TGFB1
23 11.93 BMP6 BMP7 ENG TGFB1
24 11.93 ENG MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
25 11.9 CCL2 ENG HGF REN TGFB1
26
Show member pathways
11.86 SMAD2 SMAD3 TGFB1
27
Show member pathways
11.84 AGTR1 NR3C2 REN TGFB1
28 11.82 SERPINE1 SMAD2 SMAD3 SMAD7
29
Show member pathways
11.81 MAPK8 SMAD2 SMAD3 TGFB1
30 11.81 BMP6 BMP7 SMAD2 SMAD3 SMAD7 TGFB1
31 11.8 BMP6 BMP7 CDH1 CTGF SERPINE1 SMAD2
32 11.78 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
33
Show member pathways
11.76 SMAD2 SMAD3 SMAD7 TGFB1
34 11.76 BMP6 BMP7 MAPK8 SMAD2 SMAD3 TGFB1
35 11.75 BMP6 BMP7 CTGF HGF TGFB1
36 11.74 CDH1 SMAD2 SMAD3
37
Show member pathways
11.73 BMP6 BMP7 SMAD7
38 11.7 AGTR1 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3
39 11.69 MAPK8 SMAD2 SMAD3
40 11.68 BMP6 BMP7 TGFB1
41 11.68 ENG SERPINE1 SMAD3
42 11.6 BMP7 CCL2 CTGF HGF SMAD7 TGFB1
43 11.59 CCL2 CD36 HGF TGFB1
44 11.58 CTGF SMAD2 SMAD3 SMAD7 TGFB1
45 11.56 MAPK8 SMAD3 TGFB1
46
Show member pathways
11.55 MAPK8 SMAD2 SMAD3 TGFB1
47 11.5 ENG SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
48 11.35 HGF SMAD2 SMAD3 TGFB1
49 11.25 BMP6 BMP7 CCL2 HGF MAPK8
50 11.05 CDH1 SMAD2 SMAD3 TGFB1

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 9.33 HGF SERPINE1 TGFB1
2 catenin complex GO:0016342 9.32 CDH1 SMAD7
3 extracellular space GO:0005615 9.32 BMP6 BMP7 CCL2 CD36 CTGF ENG
4 SMAD protein complex GO:0071141 9.26 SMAD2 SMAD3
5 SMAD2-SMAD3 protein complex GO:0071144 8.96 SMAD2 SMAD3
6 extracellular region GO:0005576 10.02 BMP6 BMP7 CCL2 CDH1 CTGF HGF

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 65)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL2 CD36 CTGF TGFB1
2 positive regulation of gene expression GO:0010628 9.98 CTGF ENG MAPK8 RGCC SMAD2 SMAD3
3 positive regulation of cell migration GO:0030335 9.97 HGF SMAD3 SPHK1 TGFB1
4 negative regulation of gene expression GO:0010629 9.96 CD36 CTGF ENG SMAD2 TGFB1
5 platelet degranulation GO:0002576 9.94 CD36 HGF SERPINE1 TGFB1
6 cellular response to lipopolysaccharide GO:0071222 9.94 CCL2 CD36 MAPK8 SERPINE1
7 positive regulation of angiogenesis GO:0045766 9.92 ENG HGF SERPINE1 SPHK1
8 ossification GO:0001503 9.91 BMP6 BMP7 CTGF
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.91 CD36 HGF TGFB1
10 kidney development GO:0001822 9.91 AGTR1 BMP6 BMP7 REN
11 response to wounding GO:0009611 9.89 CCL2 CTGF TGFB1
12 response to glucose GO:0009749 9.89 CTGF SMAD2 TGFB1
13 transforming growth factor beta receptor signaling pathway GO:0007179 9.88 CCL2 SMAD2 SMAD3 SMAD7 TGFB1
14 cell chemotaxis GO:0060326 9.87 AGTR1 CCL2 HGF
15 cellular response to mechanical stimulus GO:0071260 9.87 BMP6 ENG MAPK8 TGFB1
16 cellular response to transforming growth factor beta stimulus GO:0071560 9.86 SMAD3 SMAD7 TGFB1
17 positive regulation of osteoblast differentiation GO:0045669 9.85 BMP6 BMP7 HGF
18 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.85 SMAD2 SMAD3 SMAD7 TGFB1
19 BMP signaling pathway GO:0030509 9.85 BMP6 BMP7 ENG SMAD7 TGFB1
20 animal organ regeneration GO:0031100 9.84 CCL2 HGF TGFB1
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.84 BMP6 BMP7 ENG TGFB1
22 positive regulation of stress fiber assembly GO:0051496 9.83 CTGF RGCC SMAD3
23 epithelial to mesenchymal transition GO:0001837 9.82 BMP7 HGF TGFB1
24 mesoderm formation GO:0001707 9.81 BMP7 SMAD2 SMAD3
25 positive regulation of epithelial to mesenchymal transition GO:0010718 9.81 RGCC SMAD2 SMAD3 TGFB1
26 positive regulation of bone mineralization GO:0030501 9.8 BMP6 BMP7 SMAD3 TGFB1
27 endoderm development GO:0007492 9.79 SMAD2 SMAD3 TGFB1
28 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.79 BMP7 SPHK1 TGFB1
29 embryonic pattern specification GO:0009880 9.77 BMP7 SMAD2 SMAD3
30 negative regulation of cell-cell adhesion GO:0022408 9.73 CDH1 TGFB1
31 positive regulation of blood coagulation GO:0030194 9.73 CD36 SERPINE1
32 pathway-restricted SMAD protein phosphorylation GO:0060389 9.73 SMAD7 TGFB1
33 positive regulation of DNA biosynthetic process GO:2000573 9.73 HGF RGCC
34 mesonephros development GO:0001823 9.73 BMP7 REN
35 lens fiber cell differentiation GO:0070306 9.72 SMAD3 TGFB1
36 negative regulation of wound healing GO:0061045 9.72 SERPINE1 SMAD3
37 positive regulation of cell-cell adhesion GO:0022409 9.72 CCL2 SMAD7
38 positive regulation of SMAD protein import into nucleus GO:0060391 9.72 BMP6 TGFB1
39 salivary gland morphogenesis GO:0007435 9.71 BMP7 TGFB1
40 embryonic foregut morphogenesis GO:0048617 9.71 SMAD2 SMAD3
41 response to cholesterol GO:0070723 9.71 SMAD2 TGFB1
42 primary miRNA processing GO:0031053 9.7 SMAD2 SMAD3
43 pericardium development GO:0060039 9.7 SMAD2 SMAD3
44 SMAD protein complex assembly GO:0007183 9.7 SMAD2 SMAD3 TGFB1
45 response to laminar fluid shear stress GO:0034616 9.69 SMAD7 TGFB1
46 regulation of removal of superoxide radicals GO:2000121 9.68 BMP7 CD36
47 nodal signaling pathway GO:0038092 9.68 SMAD2 SMAD3
48 common-partner SMAD protein phosphorylation GO:0007182 9.67 SMAD2 TGFB1
49 regulation of striated muscle tissue development GO:0016202 9.66 SMAD3 TGFB1
50 renin-angiotensin regulation of aldosterone production GO:0002018 9.65 AGTR1 REN

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 15)
id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.8 BMP6 BMP7 CCL2 TGFB1
2 protein heterodimerization activity GO:0046982 9.8 AGTR1 BMP6 HGF SMAD2 SMAD3 TGFB1
3 beta-catenin binding GO:0008013 9.7 CDH1 SMAD3 SMAD7
4 activin binding GO:0048185 9.55 ENG SMAD7
5 growth factor activity GO:0008083 9.55 BMP6 BMP7 CTGF HGF TGFB1
6 co-SMAD binding GO:0070410 9.54 SMAD2 SMAD3
7 I-SMAD binding GO:0070411 9.51 SMAD2 SMAD7
8 BMP receptor binding GO:0070700 9.46 BMP6 BMP7
9 primary miRNA binding GO:0070878 9.43 SMAD2 SMAD3
10 R-SMAD binding GO:0070412 9.43 RGCC SMAD2 SMAD3
11 type II transforming growth factor beta receptor binding GO:0005114 9.4 ENG TGFB1
12 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.37 SMAD2 SMAD3
13 transforming growth factor beta receptor binding GO:0005160 9.35 BMP6 BMP7 SMAD2 SMAD3 TGFB1
14 type I transforming growth factor beta receptor binding GO:0034713 8.92 ENG SMAD2 SMAD7 TGFB1
15 protein binding GO:0005515 10.41 AGTR1 BMP7 CD36 CDH1 CTGF ENG

Sources for Renal Fibrosis

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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