MCID: RNL077
MIFTS: 49

Renal Fibrosis

Categories: Nephrological diseases

Aliases & Classifications for Renal Fibrosis

MalaCards integrated aliases for Renal Fibrosis:

Name: Renal Fibrosis 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:0050855
UMLS 69 C0151650

Summaries for Renal Fibrosis

MalaCards based summary : Renal Fibrosis is related to ureteral obstruction and microvascular complications of diabetes 3. An important gene associated with Renal Fibrosis is TGFB1 (Transforming Growth Factor Beta 1), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Tacrolimus and Mycophenolic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, colon and endothelial, and related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Renal Fibrosis

Diseases related to Renal Fibrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 ureteral obstruction 30.8 AGTR1 BMP6 BMP7 TGFB1
2 microvascular complications of diabetes 3 30.3 AGTR1 CTGF TGFB1
3 nephronophthisis 20 10.8
4 fibrosis of extraocular muscles, congenital, 1 10.7
5 cholecystolithiasis 10.4 BMP6 CTGF TGFB1
6 malignant renovascular hypertension 10.3 REN SERPINE1
7 localized scleroderma 10.3 BMP6 CTGF SMAD3 TGFB1
8 scleroderma, familial progressive 10.2 BMP6 CD36 CTGF
9 ocular cicatricial pemphigoid 10.2 CD36 CTGF TGFB1
10 pauci-immune glomerulonephritis 10.2 BMP7 CTGF SMAD2
11 penile disease 10.2 SMAD2 SMAD3 TGFB1
12 fibromuscular dysplasia 10.2 AGTR1 REN TGFB1
13 pulmonary fibrosis 10.2 CCL2 CTGF SMAD3 TGFB1
14 idiopathic interstitial pneumonia 10.2 CCL2 CTGF SERPINE1 TGFB1
15 gingival overgrowth 10.2 CD36 CTGF TGFB1
16 gingival fibromatosis 10.1 CD36 CTGF TGFB1
17 urinary system disease 10.1 CCL2 CTGF REN TGFB1
18 spastic paraplegia 3, autosomal dominant 10.1 CDH1 CTGF SMAD2
19 anuria 10.1 AGTR1 NR3C2 REN
20 arthrogryposis, distal, type 3 10.1 NR3C2 REN
21 familial hypertension 10.1 AGTR1 NR3C2 REN
22 malignant secondary hypertension 10.0 REN SERPINE1
23 marfan syndrome 10.0 AGTR1 BMP6 CD36
24 kidney disease 10.0
25 iga glomerulonephritis 10.0 AGTR1 CCL2 REN TGFB1
26 otosclerosis 10.0 AGTR1 CD36 TGFB1
27 acquired metabolic disease 10.0 CCL2 REN SERPINE1
28 hypertensive heart disease 10.0 AGTR1 CD36 NR3C2
29 chagas disease 10.0 CCL2 SMAD2 TGFB1
30 ischemia 9.9
31 central serous chorioretinopathy 9.9 NR3C2 SERPINE1
32 peyronie's disease 9.9 CCL2 SMAD3 SMAD7 TGFB1
33 microvascular complications of diabetes 4 9.9
34 microvascular complications of diabetes 6 9.9
35 microvascular complications of diabetes 7 9.9
36 chronic kidney failure 9.9
37 arteries, anomalies of 9.9 AGTR1 CCL2 REN SERPINE1
38 stroke, ischemic 9.9 AGTR1 BMP7 REN SERPINE1
39 nephrosclerosis 9.9 AGTR1 CCL2 CTGF NR3C2 TGFB1
40 biliary atresia 9.9 CTGF HGF TGFB1
41 hypochondrogenesis 9.8 SMAD2 SMAD3 SMAD7
42 hypoxia 9.8
43 microvascular complications of diabetes 1 9.8 CCL2 CTGF HGF
44 glomerulonephritis 9.8
45 endotheliitis 9.8
46 vitreoretinopathy, neovascular inflammatory 9.8 CCL2 CTGF HGF TGFB1
47 hypertension, essential 9.7 AGTR1 NR3C2 REN SERPINE1
48 hypertrophic scars 9.7 BMP6 CD36 SMAD2 SMAD3 TGFB1
49 liver cirrhosis 9.7 CTGF HGF REN TGFB1
50 blood group, i system 9.6

Graphical network of the top 20 diseases related to Renal Fibrosis:



Diseases related to Renal Fibrosis

Symptoms & Phenotypes for Renal Fibrosis

MGI Mouse Phenotypes related to Renal Fibrosis:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.5 SERPINE1 SMAD2 SMAD7 SMAD3 SPHK1 TGFB1
2 growth/size/body region MP:0005378 10.4 SERPINE1 SMAD2 SMAD7 SMAD3 TGFB1 CTGF
3 cellular MP:0005384 10.34 SMAD3 SMAD2 SMAD7 SPHK1 TGFB1 CDH1
4 hematopoietic system MP:0005397 10.29 SMAD3 SERPINE1 SMAD2 SMAD7 SPHK1 TGFB1
5 homeostasis/metabolism MP:0005376 10.27 SERPINE1 SMAD3 SMAD2 SMAD7 SPHK1 TGFB1
6 embryo MP:0005380 10.26 SMAD3 SMAD2 SMAD7 SPHK1 TGFB1 BMP7
7 immune system MP:0005387 10.25 SMAD3 SERPINE1 SMAD2 SMAD7 SPHK1 TGFB1
8 mortality/aging MP:0010768 10.22 SERPINE1 SMAD2 SMAD7 SMAD3 SPHK1 TGFB1
9 endocrine/exocrine gland MP:0005379 10.21 SMAD3 SMAD2 SMAD7 SPHK1 TGFB1 CDH1
10 digestive/alimentary MP:0005381 10.19 SMAD3 SMAD2 SMAD7 TGFB1 CDH1 BMP7
11 craniofacial MP:0005382 10.09 SMAD3 SMAD2 SMAD7 TGFB1 BMP7 MAPK8
12 integument MP:0010771 10.06 SERPINE1 SMAD3 SMAD2 SMAD7 TGFB1 CDH1
13 nervous system MP:0003631 10 SMAD3 SMAD2 SPHK1 TGFB1 BMP7 AGTR1
14 liver/biliary system MP:0005370 9.97 SERPINE1 SMAD3 SMAD2 TGFB1 CD36 CTGF
15 renal/urinary system MP:0005367 9.85 SMAD3 SERPINE1 TGFB1 CD36 AGTR1 BMP7
16 reproductive system MP:0005389 9.65 SMAD3 SMAD2 SMAD7 TGFB1 CDH1 BMP7
17 vision/eye MP:0005391 9.23 SMAD3 SMAD2 TGFB1 BMP7 CD36 MAPK8

Drugs & Therapeutics for Renal Fibrosis

Drugs for Renal Fibrosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
2
Mycophenolic acid Approved Phase 4,Phase 3 24280-93-1 446541
3
Mycophenolate mofetil Approved, Investigational Phase 4,Phase 3 128794-94-5 5281078
4
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
5
rituximab Approved Phase 4 174722-31-7 10201696
6
Basiliximab Approved, Investigational Phase 4,Phase 3 179045-86-4, 152923-56-3
7 Angiotensinogen Phase 4
8 Anti-Bacterial Agents Phase 4,Phase 3
9 Anti-Infective Agents Phase 4,Phase 3
10 Immunosuppressive Agents Phase 4,Phase 3
11 Antibiotics, Antitubercular Phase 4,Phase 3
12 Calcineurin Inhibitors Phase 4,Phase 3,Early Phase 1
13 Antitubercular Agents Phase 4,Phase 3
14 Vasoconstrictor Agents Phase 4
15 Angiotensin-Converting Enzyme Inhibitors Phase 4,Phase 3
16 Immunoglobulin A Phase 4
17 Immunoglobulins Phase 4
18 Antibodies Phase 4
19 Antirheumatic Agents Phase 4,Phase 3,Phase 2
20 Vaccines Phase 4
21 Antibodies, Monoclonal Phase 4
22 Antilymphocyte Serum Phase 4
23 Omega 3 Fatty Acid Nutraceutical Phase 4
24
Spironolactone Approved Phase 3 1952-01-7, 52-01-7 5833
25
Eplerenone Approved Phase 3 107724-20-9 443872 150310
26
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
27
Everolimus Approved Phase 3 159351-69-6 6442177
28
Sirolimus Approved, Investigational Phase 3 53123-88-9 46835353 6436030 5284616
29
Ramipril Approved Phase 3 87333-19-5 5362129
30
Lactitol Investigational Phase 3 585-86-4 3871
31 diuretics Phase 3,Phase 2
32
protease inhibitors Phase 3,Phase 2
33 Mineralocorticoid Receptor Antagonists Phase 3,Phase 2
34 Mineralocorticoids Phase 3,Phase 2
35 Natriuretic Agents Phase 3,Phase 2
36 Cyclosporins Phase 3
37 HIV Protease Inhibitors Phase 3,Phase 2
38 Hormone Antagonists Phase 3,Phase 2
39 Dermatologic Agents Phase 3
40 Hormones Phase 3,Phase 2
41 Diuretics, Potassium Sparing Phase 3,Phase 2
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
43 Antifungal Agents Phase 3
44 Antihypertensive Agents Phase 3
45
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
46
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
47
Pirfenidone Approved, Investigational Phase 2 53179-13-8 40632
48 Racepinephrine Approved Phase 2 329-65-7
49 Dexamethasone acetate Phase 2 1177-87-3
50 Analgesics Phase 2

Interventional clinical trials:

(show all 19)

# Name Status NCT ID Phase Drugs
1 Effect of 3g Versus 2 g MMF in Combination With Tacrolimus on Progression of Renal Allograft Interstitial Fibrosis Unknown status NCT01860183 Phase 4 Mycophenolate mofetil
2 Rituximab in Progressive Immunoglobulin A (IgA) Nephropathy Completed NCT00498368 Phase 4 Intravenous Rituximab;ACE/ARB
3 ATG Versus Basiliximab in Kidney Transplant Displaying Low Immunological Risk But High Susceptibility to DGF Terminated NCT02056938 Phase 4 Anti-Thymocyte Globulins treatment;Basiliximab treatment
4 Effect of Eplerenone on Endothelial Function in Metabolic Syndrome Completed NCT01319344 Phase 3 Eplerenone
5 Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant Recipients Completed NCT01079143 Phase 3 Certican®;Neoral;Myfortic;Simulect®;Corticosteroids
6 Efficacy and Safety Study to Delay Renal Failure in Children With Alport Syndrome Active, not recruiting NCT01485978 Phase 3 Ramipril;placebo to ramipril;Ramipril
7 Pirfenidone to Treat Kidney Disease (Focal Segmental Glomerulosclerosis) Completed NCT00001959 Phase 2 Pirfenidone
8 Once-A-Month Steroid Treatment for Patients With Focal Segmental Glomerulosclerosis Completed NCT00004990 Phase 2 Dexamethasone
9 Bioprofiling Response to Mineralocorticoid Receptor Antagonists for the Prevention of Heart Failure Recruiting NCT02556450 Phase 2 Spironolacton
10 Traditional Chinese Medicine (TCM) Colon Dialysis Treats Non-dialysis End-Stage Kidney Disease Recruiting NCT03142529 Phase 1, Phase 2 colon lotion
11 Interest Of Renal Elastography In Children As A Diagnostic Tool Of Renal Fibrosis: Confrontation To Histological Features Of Renal Biopsies Unknown status NCT01613625
12 Study of Urinary Angiotensinogen as a Marker to Warn the Deterioration of Renal Function in CKD Patients Early. Unknown status NCT01118494
13 Evaluation Of The Efficacy of a Strain-Specific Probiotic Formulation in Hemodialysis Patients Completed NCT03066921
14 Effects of High Dietary Fiber Supplementation in Diabetic Chronic Kidney Disease Completed NCT01838330
15 Role of Nox2 in CNI-induced Renal Fibrosis Recruiting NCT01674465 Early Phase 1
16 Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study Active, not recruiting NCT01696253
17 Telmisartan Promotes the Differentiation of Monocytes Into Macrophages M2 in Diabetic Nephropathy? Not yet recruiting NCT02768948 telmisartan during 6 months;Losartan during 6 months
18 Predictive Value of PIIINP Urinary for the Development of Chronic Renal Failure in Patients With Cystic Fibrosis After Lung Transplantation (MUCO-IRC) Terminated NCT01572194
19 ACTH Treatment of APOL1- Associated Nephropathy Withdrawn NCT02006849 Acthar

Search NIH Clinical Center for Renal Fibrosis

Genetic Tests for Renal Fibrosis

Anatomical Context for Renal Fibrosis

MalaCards organs/tissues related to Renal Fibrosis:

38
Kidney, Colon, Endothelial, Bone, Monocytes, Heart, Lung

Publications for Renal Fibrosis

Articles related to Renal Fibrosis:

(show top 50) (show all 320)
# Title Authors Year
1
Sphingolipid signaling in renal fibrosis. ( 29343457 )
2018
2
Adenovirus-mediated P311 ameliorates renal fibrosis through inhibition of epithelial-mesenchymal transition via TGF-I^1-Smad-ILK pathway in unilateral ureteral obstruction rats. ( 29436600 )
2018
3
Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells. ( 29440280 )
2018
4
Role of hypoxia-inducible factor-1 in the development of renal fibrosis in mouse obstructed kidney: Special references to HIF-1 dependent gene expression of profibrogenic molecules. ( 29352658 )
2018
5
Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/I^-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling. ( 29383936 )
2018
6
Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption. ( 29425932 )
2018
7
Silencing of LncRNA TCONS_00088786 reduces renal fibrosis through miR-132. ( 29364484 )
2018
8
A PEG-based method for the isolation of urinary exosomes and its application in renal fibrosis diagnostics using cargo miR-29c and miR-21 analysis. ( 29330775 )
2018
9
Hypoxia-induced activation of Twist/miR-214/E-cadherin axis promotes renal tubular epithelial cell mesenchymal transition and renal fibrosis. ( 29277613 )
2018
10
Renal fibrosis: Primacy of the proximal tubule. ( 29425694 )
2018
11
Impairment of PPAR<i>I+</i>and the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging. ( 29440279 )
2018
12
Induction of cytochrome P450 4A14 contributes to angiotensin II-induced renal fibrosis in mice. ( 29277328 )
2018
13
Human umbilical cord mesenchymal stem cell conditioned medium attenuates renal fibrosis by reducing inflammation and epithelial-to-mesenchymal transition via the TLR4/NF-I_B signaling pathway in vivo and in vitro. ( 29329595 )
2018
14
Metformin attenuates folic-acid induced renal fibrosis in mice. ( 29380373 )
2018
15
Periostin-binding DNA aptamer treatment attenuates renal fibrosis under diabetic conditions. ( 28819200 )
2017
16
PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury. ( 28045076 )
2017
17
Longitudinal assessment of rabbit renal fibrosis induced by unilateral ureteral obstruction using two-dimensional susceptibility weighted imaging. ( 29236342 )
2017
18
Renal ischemia reperfusion injury causes hypertension and renal perfusion impairment in the CD1 mice which promotes progressive renal fibrosis. ( 29357437 )
2017
19
Feature selection and classification of urinary mRNA microarray data by iterative random forest to diagnose renal fibrosis: a two-stage study. ( 28045061 )
2017
20
Complement inhibition attenuates acute kidney injury after ischemia-reperfusion and limits progression to renal fibrosis in mice. ( 28832655 )
2017
21
Murine Precision-Cut Kidney Slices as an<i>ex vivo</i>Model to Evaluate the Role of Transforming Growth Factor-I^1 Signaling in the Onset of Renal Fibrosis. ( 29311960 )
2017
22
Complement C5a receptors C5L2 and C5aR in renal fibrosis. ( 28903945 )
2017
23
Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis. ( 28848189 )
2017
24
AMP-activated protein kinase/myocardin-related transcription factor-A signaling regulates fibroblast activation and renal fibrosis. ( 28739141 )
2017
25
Corrigendum to "Dual Inhibiting Senescence and Epithelial-to-Mesenchymal Transition by Erythropoietin Preserve Tubular Epithelial Cell Regeneration and Ameliorate Renal Fibrosis in Unilateral Ureteral Obstruction". ( 28567417 )
2017
26
Potential association between elevated serum human epididymis protein 4 and renal fibrosis: A systemic review and meta-analysis. ( 28885334 )
2017
27
Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP). ( 28919491 )
2017
28
H2S improves renal fibrosis in STZ-induced diabetic rats by ameliorating TGF-I^1 expression. ( 27882817 )
2017
29
Pathophysiological Mechanisms of Renal Fibrosis: A Review of Animal Models and Therapeutic Strategies. ( 28064215 )
2017
30
Lecru L, Desterke C, Grassin-Delyle S, etA al. Cannabinoid receptor 1 is a major mediator of renal fibrosis. Kidney Int. 2015;88:72-84. ( 28938941 )
2017
31
Untargeted DNA-Demethylation Therapy Neither Prevents Nor Attenuates Ischemia-Reperfusion-Induced Renal Fibrosis. ( 28750405 )
2017
32
Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction. ( 28697727 )
2017
33
BMP7-induced-Pten inhibits Akt and prevents renal fibrosis. ( 28923783 )
2017
34
Pioglitazone Improves Mitochondrial Function in the Remnant Kidney and Protects against Renal Fibrosis in 5/6 Nephrectomized Rats. ( 28860994 )
2017
35
Sinomenine Hydrochloride Attenuates Renal Fibrosis by Inhibiting Excessive Autophagy Induced by Adriamycin: An Experimental Study. ( 28798804 )
2017
36
Renal fibrosis: Recent translational aspects. ( 29292218 )
2017
37
Psoralea corylifolia L. Seed Extract Attenuates Diabetic Nephropathy by Inhibiting Renal Fibrosis and Apoptosis in Streptozotocin-Induced Diabetic Mice. ( 28767064 )
2017
38
Therapeutic activity of the histone deacetylase inhibitor SB939 on renal fibrosis. ( 27855304 )
2017
39
Transcriptome Identified lncRNAs Associated with Renal Fibrosis in UUO Rat Model. ( 28912732 )
2017
40
N-Acetylcysteine AttenuatesA the Development of Renal Fibrosis in Transgenic Mice with Dilated Cardiomyopathy. ( 29255249 )
2017
41
The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury. ( 28198766 )
2017
42
Nrf2 deficiency promotes the progression from acute tubular damage to chronic renal fibrosis following unilateral ureteral obstruction. ( 29126308 )
2017
43
Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. ( 27784694 )
2017
44
NiaoDuQing granules relieve chronic kidney disease symptoms by decreasing renal fibrosis and anemia. ( 28915563 )
2017
45
Sphingosine kinase 1 protects renal tubular epithelial cells from renal fibrosis via induction of autophagy. ( 28733250 )
2017
46
Selective tubular activation of hypoxia-inducible factor-2I+ has dual effects on renal fibrosis. ( 28900259 )
2017
47
Shenqi detoxification granule combined with P311 inhibits epithelial-mesenchymal transition in renal fibrosis via TGF-I^1-Smad-ILK pathway. ( 29311449 )
2017
48
Klotho as a Therapeutic Target during the Development of Renal Fibrosis. ( 27951565 )
2017
49
Targeting renal fibrosis: Mechanisms and drug delivery systems. ( 29288033 )
2017
50
A novel acetyltransferase p300 inhibitor ameliorates hypertension-associated cardio-renal fibrosis. ( 28933600 )
2017

Variations for Renal Fibrosis

Expression for Renal Fibrosis

Search GEO for disease gene expression data for Renal Fibrosis.

Pathways for Renal Fibrosis

Pathways related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.83 BMP6 BMP7 CCL2 CDH1 CTGF HGF
2
Show member pathways
13.51 AGTR1 BMP6 BMP7 CCL2 CDH1 CTGF
3
Show member pathways
13.31 BMP6 BMP7 CCL2 CDH1 CTGF HGF
4
Show member pathways
13.28 BMP6 BMP7 CDH1 CTGF HGF MAPK8
5
Show member pathways
13.06 AGTR1 BMP6 BMP7 CCL2 CTGF HGF
6
Show member pathways
13.05 CDH1 HGF MAPK8 SMAD2 SMAD3 TGFB1
7 12.87 AGTR1 CDH1 HGF MAPK8 SMAD2 SMAD3
8
Show member pathways
12.77 CDH1 HGF SMAD2 SMAD3 TGFB1
9
Show member pathways
12.7 BMP6 BMP7 CTGF HGF TGFB1
10
Show member pathways
12.57 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3 TGFB1
11
Show member pathways
12.5 BMP7 SMAD2 SMAD3 SPHK1 TGFB1
12 12.41 MAPK8 SMAD2 SMAD3 TGFB1
13 12.37 CDH1 SMAD2 SMAD3 TGFB1
14
Show member pathways
12.34 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
15
Show member pathways
12.23 MAPK8 SMAD2 SMAD3 TGFB1
16 12.21 BMP6 BMP7 CTGF SERPINE1 SMAD2 SMAD3
17 12.19 CDH1 SMAD2 SMAD3 TGFB1
18 12.17 SERPINE1 SMAD2 SMAD3 TGFB1
19
Show member pathways
12.15 MAPK8 SMAD2 SMAD3 TGFB1
20
Show member pathways
12.1 MAPK8 SMAD2 SMAD3 TGFB1
21 12.1 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
22 12.1 BMP6 BMP7 MAPK8 SMAD2 SMAD3 TGFB1
23 12 CCL2 CD36 HGF TGFB1
24 12 AGTR1 CDH1 CTGF SERPINE1 SMAD2 SMAD3
25 11.95 MAPK8 SMAD2 SMAD3 SMAD7 TGFB1
26 11.89 CCL2 HGF REN TGFB1
27 11.87 BMP6 BMP7 TGFB1
28
Show member pathways
11.86 SMAD2 SMAD3 TGFB1
29
Show member pathways
11.84 SMAD2 SMAD3 TGFB1
30
Show member pathways
11.84 AGTR1 NR3C2 REN TGFB1
31
Show member pathways
11.82 MAPK8 SMAD2 SMAD3 TGFB1
32 11.81 SERPINE1 SMAD2 SMAD3 SMAD7
33 11.77 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
34 11.77 BMP6 BMP7 SMAD2 SMAD3 SMAD7 TGFB1
35
Show member pathways
11.76 SMAD2 SMAD3 SMAD7 TGFB1
36 11.73 CDH1 SMAD2 SMAD3
37
Show member pathways
11.73 BMP6 BMP7 SMAD7
38 11.7 AGTR1 CCL2 MAPK8 SERPINE1 SMAD2 SMAD3
39 11.69 MAPK8 SMAD2 SMAD3
40 11.68 BMP6 BMP7 TGFB1
41
Show member pathways
11.64 MAPK8 SMAD2 SMAD3 TGFB1
42 11.62 SERPINE1 SMAD2 SMAD3 SMAD7 TGFB1
43 11.58 CCL2 CD36 HGF TGFB1
44 11.56 MAPK8 SMAD3 TGFB1
45 11.54 CTGF SMAD2 SMAD3 SMAD7 TGFB1
46 11.53 BMP7 CCL2 CTGF HGF SMAD7 TGFB1
47 11.46 BMP6 BMP7 CDH1 CTGF SERPINE1 SMAD2
48 11.34 HGF SMAD2 SMAD3 TGFB1
49 11.25 BMP6 BMP7 CCL2 HGF MAPK8
50 11.05 BMP6 BMP7 CCL2 CDH1 CTGF HGF

GO Terms for Renal Fibrosis

Cellular components related to Renal Fibrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular GO:0005622 9.76 AGTR1 CCL2 CD36 MAPK8 REN SMAD2
2 extracellular space GO:0005615 9.61 BMP6 BMP7 CCL2 CD36 CTGF HGF
3 platelet alpha granule lumen GO:0031093 9.43 HGF SERPINE1 TGFB1
4 catenin complex GO:0016342 9.37 CDH1 SMAD7
5 SMAD protein complex GO:0071141 9.32 SMAD2 SMAD3
6 heteromeric SMAD protein complex GO:0071144 8.62 SMAD2 SMAD3
7 extracellular region GO:0005576 10.06 BMP6 BMP7 CCL2 CDH1 CTGF HGF

Biological processes related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.98 CCL2 CD36 CTGF TGFB1
2 positive regulation of gene expression GO:0010628 9.98 CD36 CTGF MAPK8 RGCC SMAD2 SMAD3
3 positive regulation of cell migration GO:0030335 9.97 HGF SMAD3 SPHK1 TGFB1
4 cellular response to lipopolysaccharide GO:0071222 9.92 CCL2 CD36 MAPK8 SERPINE1
5 platelet degranulation GO:0002576 9.92 CD36 HGF SERPINE1 TGFB1
6 wound healing GO:0042060 9.9 SMAD2 SMAD3 TGFB1
7 response to organic substance GO:0010033 9.9 CDH1 REN TGFB1
8 ossification GO:0001503 9.9 BMP6 BMP7 CTGF
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.89 CD36 HGF TGFB1
10 kidney development GO:0001822 9.89 AGTR1 BMP6 BMP7 REN
11 cellular response to mechanical stimulus GO:0071260 9.88 BMP6 MAPK8 TGFB1
12 response to glucose GO:0009749 9.88 CTGF SMAD2 TGFB1
13 cell chemotaxis GO:0060326 9.87 AGTR1 CCL2 HGF
14 transforming growth factor beta receptor signaling pathway GO:0007179 9.86 SMAD2 SMAD3 SMAD7 TGFB1
15 cellular response to transforming growth factor beta stimulus GO:0071560 9.85 SMAD3 SMAD7 TGFB1
16 BMP signaling pathway GO:0030509 9.84 BMP6 BMP7 SMAD7 TGFB1
17 positive regulation of osteoblast differentiation GO:0045669 9.83 BMP6 BMP7 HGF
18 positive regulation of cell death GO:0010942 9.83 BMP7 CD36 CTGF
19 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.83 SMAD2 SMAD3 SMAD7 TGFB1
20 positive regulation of stress fiber assembly GO:0051496 9.82 CTGF RGCC SMAD3
21 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.82 BMP6 BMP7 TGFB1
22 epithelial to mesenchymal transition GO:0001837 9.8 BMP7 HGF TGFB1
23 mesoderm formation GO:0001707 9.79 BMP7 SMAD2 SMAD3
24 endoderm development GO:0007492 9.78 SMAD2 SMAD3 TGFB1
25 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.77 BMP7 SPHK1 TGFB1
26 embryonic pattern specification GO:0009880 9.76 BMP7 SMAD2 SMAD3
27 negative regulation of wound healing GO:0061045 9.73 SERPINE1 SMAD3
28 negative regulation of cell-cell adhesion GO:0022408 9.73 CDH1 TGFB1
29 positive regulation of blood coagulation GO:0030194 9.73 CD36 SERPINE1
30 lens fiber cell differentiation GO:0070306 9.72 SMAD3 TGFB1
31 pathway-restricted SMAD protein phosphorylation GO:0060389 9.72 SMAD7 TGFB1
32 positive regulation of collagen biosynthetic process GO:0032967 9.72 CTGF RGCC TGFB1
33 positive regulation of DNA biosynthetic process GO:2000573 9.71 HGF RGCC
34 mesonephros development GO:0001823 9.71 BMP7 REN
35 response to cholesterol GO:0070723 9.71 SMAD2 TGFB1
36 positive regulation of bone mineralization GO:0030501 9.71 BMP6 BMP7 SMAD3 TGFB1
37 salivary gland morphogenesis GO:0007435 9.7 BMP7 TGFB1
38 primary miRNA processing GO:0031053 9.69 SMAD2 SMAD3
39 embryonic foregut morphogenesis GO:0048617 9.69 SMAD2 SMAD3
40 positive regulation of SMAD protein import into nucleus GO:0060391 9.69 BMP6 SMAD3 TGFB1
41 pericardium development GO:0060039 9.68 SMAD2 SMAD3
42 response to laminar fluid shear stress GO:0034616 9.68 SMAD7 TGFB1
43 nodal signaling pathway GO:0038092 9.67 SMAD2 SMAD3
44 regulation of removal of superoxide radicals GO:2000121 9.66 BMP7 CD36
45 common-partner SMAD protein phosphorylation GO:0007182 9.65 SMAD2 TGFB1
46 regulation of striated muscle tissue development GO:0016202 9.64 SMAD3 TGFB1
47 renin-angiotensin regulation of aldosterone production GO:0002018 9.63 AGTR1 REN
48 SMAD protein complex assembly GO:0007183 9.63 SMAD2 SMAD3 TGFB1
49 paraxial mesoderm morphogenesis GO:0048340 9.58 SMAD2 SMAD3
50 evasion or tolerance of host defenses by virus GO:0019049 9.57 SMAD3 TGFB1

Molecular functions related to Renal Fibrosis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.85 AGTR1 BMP6 HGF SMAD2 SMAD3 TGFB1
2 cytokine activity GO:0005125 9.78 BMP6 BMP7 CCL2 TGFB1
3 beta-catenin binding GO:0008013 9.69 CDH1 SMAD3 SMAD7
4 growth factor activity GO:0008083 9.55 BMP6 BMP7 CTGF HGF TGFB1
5 enhancer binding GO:0035326 9.54 SMAD2 SMAD3
6 co-SMAD binding GO:0070410 9.52 SMAD2 SMAD3
7 R-SMAD binding GO:0070412 9.5 RGCC SMAD2 SMAD3
8 I-SMAD binding GO:0070411 9.49 SMAD2 SMAD7
9 BMP receptor binding GO:0070700 9.46 BMP6 BMP7
10 primary miRNA binding GO:0070878 9.43 SMAD2 SMAD3
11 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity GO:0030618 9.4 SMAD2 SMAD3
12 type I transforming growth factor beta receptor binding GO:0034713 9.13 SMAD2 SMAD7 TGFB1
13 transforming growth factor beta receptor binding GO:0005160 9.02 BMP6 BMP7 SMAD2 SMAD3 TGFB1
14 protein binding GO:0005515 10.23 AGTR1 BMP7 CCL2 CD36 CDH1 CTGF

Sources for Renal Fibrosis

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