GLYS
MCID: RNL024
MIFTS: 50

Renal Glucosuria (GLYS) malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Metabolic diseases

Aliases & Classifications for Renal Glucosuria

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Aliases & Descriptions for Renal Glucosuria:

Name: Renal Glucosuria 52 48 24 70 12
Renal Glycosuria 35 11 48 13
Familial Renal Glucosuria 54 27 68
Glycosuria, Renal 39 68
Glys1 24 70
 
Glucosuria, Renal 70
Sglt2 Deficiency 54
Renal Diabetes 11
Diabetes Renal 50
Glys 70

Characteristics:

Orphanet epidemiological data:

54
familial renal glucosuria:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: All ages

HPO:

64
renal glucosuria:
Inheritance: autosomal dominant inheritance, autosomal recessive inheritance
Onset and clinical course: variable expressivity

Classifications:



External Ids:

OMIM52 233100
Disease Ontology11 DOID:9432
ICD1030 E74.8
ICD9CM32 271.4
MeSH39 D006030
Orphanet54 ORPHA69076
ICD10 via Orphanet31 E74.8
MedGen37 C0017980

Summaries for Renal Glucosuria

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NIH Rare Diseases:48 Renal glycosuria is a rare condition in which glucose is excreted in the urine despite normal or low blood glucose levels. with normal kidney function, glucose is excreted in the urine only when there are abnormally elevated levels of glucose in the blood. however, in people with renal glycosuria, glucose is abnormally eliminated in the urine due to improper functioning of the renal tubules, which are the primary components of the filtering units of the kidneys. in most people with renal glycosuria, there are no apparent symptoms or serious effects. rare cases of polyuria (increased urine output), enuresis (involuntary urination), and mild growth and pubertal maturational delay have been reported. when renal glycosuria occurs as an isolated finding with otherwise normal kidney function, the condition is thought to be inherited in an autosomal recessive manner, caused by mutations in the  slc5a2 gene. treatment is not typically needed. last updated: 1/20/2016

MalaCards based summary: Renal Glucosuria, also known as renal glycosuria, is related to cataract, juvenile, with microcornea and glucosuria and renal cysts and diabetes syndrome, and has symptoms including polyuria, polydipsia and polyphagia. An important gene associated with Renal Glucosuria is SLC5A2 (Solute Carrier Family 5 Member 2), and among its related pathways are Carbohydrate digestion and absorption and Type II diabetes mellitus. Affiliated tissues include kidney.

OMIM:52 Patients with familial renal glucosuria have decreased renal tubular resorption of glucose form the urine in the... (233100) more...

UniProtKB/Swiss-Prot:70 Renal glucosuria: A disorder characterized by persistent isolated glucosuria, normal fasting serum glucose concentration, decreased renal tubular resorption of glucose from the urine, and absence of any other signs of tubular dysfunction.

Wikipedia:71 Renal glycosuria, also known as renal glucosuria, is a rare condition in which the simple sugar glucose... more...

Related Diseases for Renal Glucosuria

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Diseases related to Renal Glucosuria via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1cataract, juvenile, with microcornea and glucosuria11.6
2renal cysts and diabetes syndrome10.8
3diabetes insipidus, nephrogenic10.7
4neuroblastoma10.3
5body dysmorphic disorder10.0SLC2A2, SLC5A2
6pyelonephritis9.9
7ectopic cushing syndrome9.9SLC2A2, SLC5A1
8aminoaciduria9.9
9thalassemia9.9
10distal muscular dystrophy9.9HNF1B, SLC2A2
11osteogenesis imperfecta9.9
12malt worker's lung9.9SLC2A1, SLC2A2
13peroneal neuropathy9.8SLC2A2, SLC5A2
14inferior myocardial infarction9.8SLC2A1, SLC2A2
15endotheliitis9.8
16glucose/galactose malabsorption9.8
17cataract9.8
18neuronitis9.7
19brain stem glioma9.7SLC2A1, SLC2A2, SLC5A2
20osteoporosis9.7
21nephrotic syndrome9.7
22acute insulin response9.6
23thrombosis9.6
24polyneuropathy9.6
25melanoma9.6
26hemophilia9.6
27colorectal cancer9.5
28porphyria cutanea tarda9.5
29spondyloepimetaphyseal dysplasia9.5
30coronary artery disease9.5
31achondroplasia9.5
32osteogenesis imperfecta, type iv9.5
33cystic fibrosis9.5
34anorexia nervosa9.5
35meconium ileus9.5
36insulin-like growth factor i9.5
37pancreatic cancer9.5
38pseudoachondroplasia9.5
39prolidase deficiency9.5
40androgen insensitivity9.5
41hemophilia b9.5
42hemophilia a9.5
43lipoprotein lipase deficiency9.5
44hemolytic anemia9.5
45hepatitis9.5
46insulinoma9.5
47liver cirrhosis9.5
48motor neuron disease9.5
49artery disease9.5
50brain glioma9.5

Comorbidity relations with Renal Glucosuria via Phenotypic Disease Network (PDN):


Chronic Kidney FailureHeart Disease

Graphical network of the top 20 diseases related to Renal Glucosuria:



Diseases related to renal glucosuria

Symptoms & Phenotypes for Renal Glucosuria

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Symptoms by clinical synopsis from OMIM:

233100

Clinical features from OMIM:

233100

Human phenotypes related to Renal Glucosuria:

 64
id Description HPO Frequency HPO Source Accession
1 polyuria64 HP:0000103
2 polydipsia64 HP:0001959
3 polyphagia64 HP:0002591
4 glycosuria64 HP:0003076
5 enuresis nocturna64 HP:0010677

Drugs & Therapeutics for Renal Glucosuria

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Drugs for Renal Glucosuria (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Insulin GlargineapprovedPhase 4528160337-95-1
Synonyms:
 
Insulin Glargine (rDNA origin)
Insulin glargine recombinant
2
Insulin-glulisineapprovedPhase 4106207748-29-6
Synonyms:
 
Insulin Glulisine (recombinant DNA origin)
Insulin glulisine recombinant
3
EmpagliflozinapprovedPhase 4, Phase 2133864070-44-0
Synonyms:
 
(1S)-1,5-anhydro-1-(4-chloro-3-{4-[(3S)-tetrahydrofuran-3-yloxy]benzyl}phenyl)-D-glucitol
1-chloro-4-(glucopyranos-1-yl)-2-(4-(tetrahydrofuran-3-yloxy)benzyl)benzene
4Angiotensin-Converting Enzyme InhibitorsPhase 4724
5Hypoglycemic AgentsPhase 4, Phase 2, Phase 15896
6potassium phosphatePhase 1, Phase 211
7Calcium, DietaryPhase 1, Phase 25713
8Phosphorus SupplementNutraceuticalPhase 1, Phase 24
9
CanagliflozinapprovedPhase 1109842133-18-0
Synonyms:
 
Canagliflozin anhydrous
10
MetforminapprovedPhase 11803657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
11
Uric Acidexperimental, investigationalPhase 114169-93-21175
Synonyms:
1H-Purine-2,6,8-triol
2,6,8-Trihydroxypurine
2,6,8-Trioxopurine
2,6,8-Trioxypurine
 
7,9-dihydro-1H-purine-2,6,8(3H)-trione
Lithate
Lithic acid
Purine-2,6,8(1H,3H,9H)-trione
Urate
Uric acid
12Trichostatin APhase 15458880-19-6
13Glucagon-Like Peptide 1Phase 1715
14HormonesPhase 114415
15DihydroxycholecalciferolsPhase 133
16glucagonPhase 1478
17
Tenofovirapproved, investigational759147127-20-6464205
Synonyms:
(R)-9-(2-Phosphonomethoxypropyl)adenine
(R)-9-(2-Phosphonylmethoxypropyl)adenine
(R)-9-(2-phosphonomethoxypropyl)adenine
(R)-PMPA
147127-20-6
206184-49-8
AC-760
AC1LA9BO
Anh. tenofovir
Anhydrous tenofovir
Apropovir
CHEBI:45809
CHEMBL483
CID464205
D,L-Tenofovir
DB00300
GNA & Tenofovir
GS 1275
GS 1278
GS1278
 
HHA & Tenofovir
KS-5021
MolPort-003-850-411
NCGC00167535-01
PMPA
PMPA-(R)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
Phosphonic acid, [[2-(6-amino-9H-purin-9
S1401_Selleck
TDF
TFV
Tenefovir
Tenofovir
Tenofovir (anh.)
Tenofovir disoproxil
Tenofovir disoproxil fumarate
UNII-99YXE507IL
Viread
Viread, Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
18
Emtricitabineapproved, investigational457143491-57-060877
Synonyms:
(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-.beta.-L-FTC
(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine
(-)-FTC
(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine
(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
143491-54-7
143491-57-0
145213-48-5
2',3',5-FTC
2',3'-Dideoxy-5-fluoro-3'-thiacytidine
2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine
2'-Deoxy-5-fluoro-3'-thiacytidine
2-FTC
3'-Thia-2'.3'-dideoxy-5-fluorocytidine
4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one
4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine
524W91
AC1L1U3I
AC1Q4KUB
BW 1592
 
BW 524W91
BW-524W91
BW524W91
C122114
C12599
C8H10FN3O3S
CHEBI:31536
CHEMBL885
CID60877
Coviracil
Coviracil(TM)
D01199
DB00879
DRG-0208
Emtricitabin
Emtricitabina
Emtricitabine
Emtricitabine (JAN/USAN/INN)
Emtricitabinum
Emtriva
Emtriva (TN)
Emtriva(TM)
FT-0080009
HMS2089I05
HSDB 7337
LS-135838
LS-173184
NCGC00164564-01
RCV
Racivir
SBB066061
TL8000958
UNII-G70B4ETF4S
ZINC03629271
beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine
dOTFC
emtricitabine
19Nucleic Acid Synthesis Inhibitors4962
20Reverse Transcriptase Inhibitors1913
21Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination248
22Antiviral Agents9967
23Anti-Infective Agents22062
24Anti-HIV Agents3162
25Anti-Retroviral Agents3296
26Fenugreek seed meal13
27Insulin, Globin Zinc4645
28insulin4646
29FenugreekNutraceutical14

Interventional clinical trials:

(show all 18)
idNameStatusNCT IDPhase
1Combined Diabetes-Renal Multifactorial Intervention In Patients With Advanced Diabetic Nephropathy (ADN)CompletedNCT00708981Phase 4
2PROTOCOL 3: Role of the Renal Nerves in the Increase in EGP in Response to GlucosuriaRecruitingNCT03168295Phase 4
3Effect of Dapagliflozin on Hepatic and Renal Glucose Metabolism SubjectsNot yet recruitingNCT02981966Phase 4
4SGLT-2 Inhibitor Empagliflozin Effects on Appetite and Weight Regulation.Not yet recruitingNCT02798744Phase 4
5Empagliflozin and Renal Oxygenation in Healthy VolunteersRecruitingNCT03093103Phase 2
6Role Of Phosphorus And FGF 23 In Patients With Dent DiseaseRecruitingNCT02016235Phase 1, Phase 2
7A Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Volunteers With Varying Degrees of Kidney FunctionCompletedNCT01759576Phase 1
8A Comparison Of Study Drug Blood Levels After One Dose Of GSK189075 In Subjects With Normal And Reduced Kidney FunctionCompletedNCT00501462Phase 1
9A First-in-Human Study of JNJ-28431754 in Healthy Male VolunteersCompletedNCT01177150Phase 1
10A Study to Assess the Pharmacokinetics and Pharmacodynamics of Canagliflozin in Healthy Chinese VolunteersCompletedNCT01707316Phase 1
11The PK/PD Study of Multiple Dose of SHR3824 in Healthy VolunteersCompletedNCT02361138Phase 1
12Study to Assess the Pharmacokinetics, Pharmacodynamics, and Safety of Canagliflozin (JNJ-28431754) in Otherwise Healthy Obese VolunteersCompletedNCT01756404Phase 1
13A Study to Evaluate the Pharmacokinetics, Pharmacodynamics and Safety of Canagliflozin in Older Children and Adolescents With Type 2 Diabetes MellitusCompletedNCT02000700Phase 1
14Genetics of Response to CanagliflozinNot yet recruitingNCT02891954Phase 1
15Renal, Endocrine, and Bone Changes in Response to FTC/TDF in Uninfected Young Men Who Have Sex With Men (YMSM).CompletedNCT01769469
16Study of Dapagliflozin on Mitochondrial Dysfunction and Impaired Insulin Signaling/ActionRecruitingNCT01439854
17Nervous System Degeneration in Glycosphingolipid Storage DisordersRecruitingNCT00029965
18Clinical Evaluation of Fenugreek Seed Extract, a Nutraceutical in Patients With Type- 2 DiabetesRecruitingNCT02693392

Search NIH Clinical Center for Renal Glucosuria


Cochrane evidence based reviews: glycosuria, renal

Genetic Tests for Renal Glucosuria

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Genetic tests related to Renal Glucosuria:

id Genetic test Affiliating Genes
1 Familial Renal Glucosuria27
2 Renal Glucosuria24 SLC5A2

Anatomical Context for Renal Glucosuria

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MalaCards organs/tissues related to Renal Glucosuria:

36
Kidney

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Renal Glucosuria:
id TissueAnatomical CompartmentCell Relevance
1 KidneyProximal TubuleProximal Tubule Cells Potential therapeutic candidate, affected by disease

Publications for Renal Glucosuria

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Articles related to Renal Glucosuria:

(show all 26)
idTitleAuthorsYear
1
Renal glucosuria is not associated with atherosclerotic cardiovascular disease outcome in a general Japanese community. (28242048)
2017
2
Genetic analysis and literature review of Chinese patients with familial renal glucosuria: Identification of a novel SLC5A2 mutation. (28365451)
2017
3
Novel SLC5A2 mutation contributes to familial renal glucosuria: Abnormal expression in renal tissues. (27446256)
2016
4
A recurrent deletion in the SLC5A2 gene including the intron 7 branch site responsible for familial renal glucosuria. (27666404)
2016
5
Determination of the renal threshold for glucose excretion in Familial Renal Glucosuria. (25896487)
2015
6
Novel SLC5A2 variants contribute to renal glucosuria in Chinese families: abnormal expression and dysfunction of variant SLC5A2. (25339128)
2015
7
A novel sodium-glucose co-transporter 2 gene (SGLT2) mutation contributes to the abnormal expression of SGLT2 in renal tissues in familial renal glucosuria. (24908283)
2014
8
Clinical and genetic analysis in a patient with primary renal glucosuria: Identification of a novel mutation in the SLC5A2 gene. (24255686)
2013
9
Hypouricaemia and hyperuricosuria in familial renal glucosuria. (26064518)
2013
10
Familial renal glucosuria: a clinicogenetic study of 23 additional cases. (22314875)
2012
11
Abnormal expression and dysfunction of novel SGLT2 mutations identified in familial renal glucosuria patients. (21165652)
2011
12
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. (19965550)
2010
13
Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria. (18304496)
2008
14
Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. (18622023)
2008
15
Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. (16518345)
2006
16
A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. (15610225)
2005
17
Gene Symbol: SLC55A2. Disease: familial renal glucosuria. (15300967)
2004
18
A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuria. (15496564)
2004
19
Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. (14614622)
2004
20
Renal glucosuria due to SGLT2 mutations. (15110322)
2004
21
Long-term outcome of renal glucosuria type 0: the original patient and his natural history. (15299100)
2004
22
Molecular analysis of the SGLT2 gene in patients with renal glucosuria. (14569097)
2003
23
Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). (12436245)
2002
24
Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine. (11325687)
2001
25
Renal glucosuria and aminoaciduria. (899885)
1977
26
Glucose-galactose malabsorption. Studies on renal glucosuria. (5438804)
1970

Variations for Renal Glucosuria

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UniProtKB/Swiss-Prot genetic disease variations for Renal Glucosuria:

70
id Symbol AA change Variation ID SNP ID
1SLC5A2p.Asn654SerVAR_019310rs61742739

Clinvar genetic disease variations for Renal Glucosuria:

5
id Gene Variation Type Significance SNP ID Assembly Location
1SLC5A2NM_ 003041.3(SLC5A2): c.1320G> A (p.Trp440Ter)SNVPathogenicrs121918621GRCh37Chr 16, 31500240: 31500240
2SLC5A2NM_ 003041.3(SLC5A2): c.1961A> G (p.Asn654Ser)SNVPathogenicrs61742739GRCh37Chr 16, 31501798: 31501798
3SLC5A2NM_ 003041.3(SLC5A2): c.500delA (p.Gln167Argfs)deletionPathogenicrs267607067GRCh37Chr 16, 31497522: 31497522
4SLC5A2NM_ 003041.3(SLC5A2): c.265G> A (p.Ala89Thr)SNVPathogenicrs886037850GRCh38Chr 16, 31484885: 31484885
5SLC5A2NM_ 003041.3(SLC5A2): c.127-16C> ASNVPathogenicrs398122801GRCh38Chr 16, 31484657: 31484657
6SLC5A2NM_ 003041.3(SLC5A2): c.1435C> G (p.Arg479Gly)SNVPathogenicrs387906682GRCh37Chr 16, 31500355: 31500355
7SLC5A2NM_ 003041.3(SLC5A2): c.294C> A (p.Phe98Leu)SNVPathogenicrs398122802GRCh37Chr 16, 31496235: 31496235

Expression for genes affiliated with Renal Glucosuria

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Search GEO for disease gene expression data for Renal Glucosuria.

Pathways for genes affiliated with Renal Glucosuria

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Pathways related to Renal Glucosuria according to GeneCards Suite gene sharing:

(show all 16)
idSuper pathwaysScoreTop Affiliating Genes
19.3SLC2A2, SLC5A1
2
Show member pathways
9.3HNF1B, SLC2A2
3
Show member pathways
9.3HNF1B, SLC2A2
49.3HNF1B, SLC2A2
5
Show member pathways
9.3HNF1B, SLC2A2
69.1SLC2A1, SLC5A1
7
Show member pathways
9.0SLC2A1, SLC2A2
89.0SLC2A1, SLC2A2
99.0SLC2A1, SLC2A2
109.0SLC2A1, SLC2A2
119.0SLC2A1, SLC2A2
128.7SLC2A1, SLC5A1, SLC5A2
138.1SLC2A1, SLC2A2, SLC5A1, SLC5A2
14
Show member pathways
8.1SLC2A1, SLC2A2, SLC5A1, SLC5A2
15
Show member pathways
8.1SLC2A1, SLC2A2, SLC5A1, SLC5A2
16
Show member pathways
8.1SLC2A1, SLC2A2, SLC5A1, SLC5A2

GO Terms for genes affiliated with Renal Glucosuria

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Cellular components related to Renal Glucosuria according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:00163249.2SLC2A1, SLC2A2, SLC5A1
2cell-cell junctionGO:00059119.2SLC2A1, SLC2A2, SLC5A1
3integral component of plasma membraneGO:00058877.6SLC16A12, SLC2A1, SLC2A2, SLC5A1, SLC5A2

Biological processes related to Renal Glucosuria according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1sodium ion transportGO:000681410.3SLC5A1, SLC5A2
2hexose transportGO:000864510.1SLC2A2, SLC5A1
3dehydroascorbic acid transportGO:00708379.8SLC2A1, SLC2A2
4regulation of insulin secretionGO:00507969.8SLC2A1, SLC2A2
5glucose transportGO:00157589.3SLC2A1, SLC2A2, SLC5A1
6carbohydrate transportGO:00086438.9SLC2A1, SLC2A2, SLC5A1, SLC5A2
7glucose transmembrane transportGO:19046598.9SLC2A1, SLC2A2, SLC5A1, SLC5A2
8transmembrane transportGO:00550858.4SLC16A12, SLC2A1, SLC2A2, SLC5A1, SLC5A2
9transportGO:00068108.1SLC2A1, SLC2A2, SLC5A1, SLC5A2

Molecular functions related to Renal Glucosuria according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1glucose:sodium symporter activityGO:000541210.1SLC5A1, SLC5A2
2D-glucose transmembrane transporter activityGO:00550569.6SLC2A1, SLC2A2
3dehydroascorbic acid transporter activityGO:00333009.6SLC2A1, SLC2A2
4glucose transmembrane transporter activityGO:00053559.6SLC2A1, SLC2A2
5substrate-specific transmembrane transporter activityGO:00228919.6SLC2A1, SLC2A2
6symporter activityGO:00152939.6SLC16A12, SLC5A1, SLC5A2
7transmembrane transporter activityGO:00228579.0SLC2A1, SLC2A2

Sources for Renal Glucosuria

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet