Renal Glucosuria malady

Wikipedia: Renal glycosuria, also known as renal glucosuria, is a rare condition in which the simple sugar glucose...⁴⁴ more...

MalaCards: Renal Glucosuria, also known as glycosuria, renal, is related to renal glycosuria and diabetes mellitus. An important gene associated with Renal Glucosuria is SLC5A2 (solute carrier family 5 (sodium/glucose cotransporter), member 2), and among its related pathways are Na+-dependent glucose transporters and Carbohydrate digestion and absorption. The compounds methyl alpha-d-glucopyranoside and phlorizin have been mentioned in the context of this disorder. Affiliated tissues include kidney.

OMIM: 233100

renal glucosuria 7 16 33 glycosuria, renal 43

glys1 16

Diseases related to renal glucosuria by text searches and GeneDecks gene sharing:

(show top 50)    (show all 282)

id	Related Disease	Score	Top Affiliating Genes
1	renal glycosuria	30.1	SLC5A2, SLC5A1
2	diabetes mellitus	29.0	SLC5A1, SLC2A2, SLC5A2
3	type 2 diabetes mellitus	27.6	SLC2A2, SLC5A2
4	glucose intolerance	24.1	SLC5A2, SLC5A1, SLC2A2
5	mucinous tubular and spindle renal cell carcinoma	12.2	SLC2A2, SLC5A2
6	hyperparathyroidism	12.1	SLC2A2, SLC5A1
7	secondary hyperparathyroidism of renal origin	12.0	SLC5A1, SLC2A2
8	hyperglycemia	11.1	SLC5A1, SLC2A2, SLC16A12, SLC5A2
9	hypertension	8.5
10	osteogenesis imperfecta	7.9
11	schizophrenia	7.9
12	parkinson's disease	7.8
13	essential hypertension	7.6
14	obesity	7.6
15	alzheimer's disease	7.4
16	amyloidosis	7.4
17	cardiomyopathy	7.2
18	carcinoma	7.1
19	cholesterol	7.0
20	insulin resistance	7.0
21	polycystic ovary syndrome	7.0
22	tardive dyskinesia	7.0
23	aminoaciduria	6.6
24	cataract	6.6
25	thalassemia	6.6
26	crohn's disease	6.6
27	polyneuropathy	6.6
28	achondroplasia	6.3
29	amyotrophic lateral sclerosis	6.3
30	colorectal cancer	6.3
31	coronary heart disease	6.3
32	ehlers-danlos syndrome	6.3
33	lateral sclerosis	6.3
34	neuronitis	6.3
35	retinitis pigmentosa	6.3
36	retinitis	6.3
37	von willebrand's disease	6.3
38	ehlers-danlos syndrome type iv	6.1
39	factor vii deficiency	6.1
40	hypophosphatasia	6.1
41	hypertrophic cardiomyopathy	6.1
42	myocardial infarction	6.1
43	pancreatitis	6.1
44	rheumatoid arthritis	6.1
45	tuberculosis	6.1
46	alpha thalassemia	6.1
47	arthritis	6.1
48	atherosclerosis	6.1
49	breast cancer	6.1
50	osteogenesis imperfecta type iii	5.7

Clinical features from OMIM: 233100

Approved drugs:

Drug clinical trials:

Genetic tests related to renal glucosuria:

id	Genetic test	Affiliating Genes
1	Renal Glucosuria clinical/research	SLC5A2

MalaCards organs/tissues related to renal glucosuria:

²²

Articles related to renal glucosuria:

id	Title	Authors	Year	Affiliating Genes
1	Abnormal expression and dysfunction of novel SGLT2 mu tations identified in familial renal glucosuria patients. (21165652)	Yu L.... Zhang H.	2011	SLC5A2
2	Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target. (19965550)	Santer R.... Calado J.	2010	SLC2A2, SLC5A1, SLC5A2
3	Twenty-one additional cases of familial renal glucosuria: absence of genetic heterogeneity, high prevalence of private mutations and further evidence of volume depletion. (18622023)	Calado J.... Santer R.	2008	SLC5A2
4	Mutation of solute carrier SLC16A12 associates with a syndrome combining juvenile cataract with microcornea and renal glucosuria. (18304496)	Kloeckener-Gruissem B.... Berger W.	2008	SLC16A12
5	Familial renal glucosuria: SLC5A2 mutation analysis and evidence of salt-wasting. (16518345)	Calado J.... Rueff J.	2006	SLC5A2
6	A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. (15610225)	Magen D.... Skorecki K.	2005	SLC5A2
7	Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria. (14614622)	Calado J.... Rueff J.	2004	SLC5A2
8	Molecular analysis of the SGLT2 gene in patients with renal glucosuria. (14569097)	Santer R.... Klaerke D.	2003	SLC5A2
9	Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2). (12436245)	van den Heuvel L.P.... Monnens L.	2002	SLC5A2
10	Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine. (11325687)	Sankarasubbaiyan S.... Heilig C.W.	2001	SLC5A2

Genes related to renal glucosuria according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	SLC5A2	solute carrier family 5 (sodium/glucose cotransporter), member 2	11.1	Summaries, Publications
2	SLC16A12	solute carrier family 16, member 12 (monocarboxylic acid transporter 12)	11.1	Publications, Summaries
3	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2	11.0	Publications
4	SLC5A1	solute carrier family 5 (sodium/glucose cotransporter), member 1	11.0	Publications

Pathways related to renal glucosuria according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Na+-dependent glucose transporters38	9.3	SLC5A1, SLC5A2
2	Carbohydrate digestion and absorption20	9.1	SLC5A1, SLC2A2
3	Selected targets of HNF110	8.8	SLC5A1, SLC2A2

Compounds related to renal glucosuria according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	methyl alpha-d-glucopyranoside32	9.7	SLC5A2, SLC5A1
2	phlorizin32	9.6	SLC5A1, SLC5A2
3	3-o-methylglucose32	9.3	SLC5A1, SLC2A2
4	monosaccharide32	9.2	SLC5A1, SLC2A2
5	fructose32 9 9	11.1	SLC5A1, SLC2A2
6	2-deoxyglucose32	9.0	SLC2A2, SLC5A1
7	mannitol32 9 9	10.8	SLC2A2, SLC5A1
8	galactose32	8.8	SLC2A2, SLC5A2, SLC5A1
9	sodium32 18	9.7	SLC5A1, SLC5A2, SLC2A2
10	glucose32	8.6	SLC2A2, SLC5A2, SLC5A1

Cellular components related to renal glucosuria according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	brush border membrane	GO:031526	8.3	SLC5A1, SLC5A2, SLC2A2
2	plasma membrane	GO:005886	8.0	SLC5A1, SLC5A2, SLC16A12, SLC2A2

Biological processes related to renal glucosuria according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	glucose transport	GO:015758	9.1	SLC2A2, SLC5A1
2	hexose transport	GO:008645	9.0	SLC5A1, SLC2A2
3	carbohydrate metabolic process	GO:005975	8.6	SLC5A1, SLC5A2, SLC2A2
4	transmembrane transport	GO:055085	8.3	SLC5A2, SLC5A1, SLC2A2