MCID: RNL015
MIFTS: 60

Renal Hypertension malady

Nephrological diseases category

Summaries for Renal Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renal Hypertension, also known as hypertensive disease, is related to hypertension and essential hypertension. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF1Alpha Pathway and Insulin Processing. The drugs diltiazem and felodipine and the compounds ornipressin and potassium chloride have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are cardiovascular system and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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8Disease Ontology, 60UMLS, 44Novoseek, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal hypertension 8 60
hypertensive disease 60
hypertension renal 44


External Ids:

Disease Ontology8 DOID:1073
NCIt39 C3121
SNOMED-CT56 194775007, 28119000
MeSH34 D006977

Related Diseases for Renal Hypertension

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17GeneCards, 18GeneDecks
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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8ALB, KNG1, ACE, EDN1, SLC12A3, REN
2essential hypertension30.8ALB, SLC12A3, REN, KNG1, ACE, EDN1
3malignant hypertension30.5ACE, REN
4renovascular hypertension30.4ACE, REN
5proteinuria30.0KNG1, ALB, EDN1, REN, ACE
6ischemia29.9KNG1, EDN1
7portal hypertension29.9ALB, EDN1
8glaucoma29.8EDN1
9pheochromocytoma29.8KNG1
10obesity29.8KNG1
11gitelman syndrome29.8REN, SLC12A3
12uremia29.8ALB, EPO
13arthritis29.8ALB, KNG1
14hypertensive nephropathy29.8ACE, ALB
15renal vascular disease29.8ALB, ACE
16vascular disease29.8EDN1, KNG1, ACE
17connective tissue disease29.7ALB
18thrombocytopenia29.7ALB, EPO
19malignant hypertensive renal disease10.3
20hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
21neuronitis10.2
22benign hypertensive renal disease10.2
23cerebritis10.2
24malignant essential hypertension10.0
25kidney hypertrophy10.0
26polycystic kidney disease10.0
27congenital mesoblastic nephroma10.0
28kidney disease10.0
29renal cell carcinoma10.0
30pulmonary fibrosis10.0EDN1
31proliferative diabetic retinopathy10.0EDN1
32cor pulmonale10.0EDN1
33hypoaldosteronism10.0REN
34fibromuscular dysplasia10.0REN
35neuropathy10.0ALB
36ulcerative colitis10.0ALB
37peritonitis10.0ALB
38cystic fibrosis10.0ALB
39vasculitis10.0ALB
40crohn's disease10.0ALB
41galactosemia10.0ALB
42allergic rhinitis10.0KNG1
43hepatitis c10.0ALB
44lupus nephritis10.0ALB
45intracranial hypertension10.0ALB
46cholestasis10.0ALB
47wilms tumor10.0REN
48polycythemia10.0EPO
49diarrhea10.0ALB
50leukemia10.0EPO

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Clinical Features for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renal Hypertension

Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Search CenterWatch for Renal Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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32MalaCards
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MalaCards organs/tissues related to Renal Hypertension:

32
Kidney, Heart, Brain, Endothelial, Testes, Smooth muscle, Lung, Cortex, Placenta, Adrenal gland, Adrenal cortex, Retina, Monocytes, Hypothalamus, Medulla oblongata, Cardiac myocytes, Cervix, Thyroid, Pancreas, Thymus, Bone

Animal Models for Renal Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8ACE, SLC12A3, REN, EPO, EDN1
2MP:00053677.6EDN1, REN, SLC12A3, ACE, ALB
3MP:00053766.6ALB, ACE, SLC12A3, REN, EPO, KNG1

Publications for Renal Hypertension

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50PubMed
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Articles related to Renal Hypertension:

(show top 50)    (show all 1337)
idTitleAuthorsYear
1
Coexisting renal artery aneurysm and adrenal adenoma in resistant hypertension. (21693375)
2011
2
Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension. (18398333)
2008
3
Genetic variants in hypertensive patients with coronary artery disease and coexisting atheromatous renal artery stenosis. (19043368)
2008
4
Lupus nephritis complicated with malignant hypertension: from renal vascular pathology to clinical relevance. (18686626)
2008
5
Genetic polymorphisms of the renin-angiotensin-aldosterone system and renal insufficiency in essential hypertension. (15662219)
2005
6
Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis. (12808303)
2003
7
Midtrimester triple-test levels in women with chronic hypertension and altered renal function. (12575027)
2003
8
Effect of efonidipine and ACE inhibitors on proteinuria in human hypertension with renal impairment. (12559677)
2003
9
Treatment of hypertension in patients with renal disease. (12766383)
2002
10
Renal dopaminergic mechanisms in renal parenchymal diseases and hypertension. (11369822)
2001
11
Hypertension associated with multiple renal arteries may be renin-dependent. (11057431)
2000
12
Long-term effects of ramipril and nitrendipine on albuminuria in hypertensive patients with type II diabetes and impaired renal function. (9928752)
1999
13
Dopamine-1 receptor coupling defect in renal proximal tubule cells in hypertension. (10205244)
1999
14
Increase in functional Ca2+ channels in cerebral smooth muscle with renal hypertension. (9648730)
1998
15
Role of the renin-angiotensin system in cardiac hypertrophy and renal glomerular sclerosis in transgenic hypertensive mice carrying both human renin and angiotensinogen genes. (9582107)
1998
16
Effects of the angiotensin converting enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential hypertensive patients. (9715789)
1998
17
A limited renal injury may cause a permanent form of neurogenic hypertension. (9657632)
1998
18
Effect of an alpha-adrenergic blocker, and ACE inhibitor and hydrochlorothiazide on blood pressure and on renal function in type 2 diabetic patients with hypertension and albuminuria. A randomized cross-over study. (9736816)
1998
19
Association between atrial natriuretic peptide and cyclic GMP in hypertension and in chronic renal failure. (9706839)
1998
20
ACE inhibitors captopril and enalapril induce regression of left ventricular hypertrophy in hypertensive patients with chronic renal failure. (9175047)
1997
21
Noninvasive diagnosis of renovascular hypertension due to bilateral renal artery stenosis using captopril intervention scintirenography: the value of computer-generated renogram data. (9062026)
1996
22
Vasoactive intestinal contractor as a genesis of renal hypertension. (7723902)
1995
23
Renal tubular sensitivity to atrial natriuretic factor in essential hypertension. (8064168)
1994
24
Renin secretion and captopril stimulation in hypertensive renal transplant recipients. (8178382)
1994
25
Pharmacokinetics and pharmacodynamics of benazepril in hypertensive patients with normal and impaired renal function. (1279278)
1992
26
Plasma erythropoietin concentrations in renal venous blood of patients with unilateral renovascular hypertension. (1314993)
1992
27
Aldosteronoma coexisting with renal artery stenosis in secondary hypertension. (1598748)
1992
28
Hypertension and renal impairment as complications of acute porphyria. (1331893)
1992
29
Normal renal tubular response to changes of sodium intake in hypertensive man. (2159502)
1990
30
Role of angiotensin converting enzyme inhibitors in essential and renal hypertension. Effects of captopril and enalapril on renin-angiotensin-aldosterone, renal function and hemodynamics, salt and water excretion, and body fluid composition. (6206722)
1984
31
Semiquantitative histochemical investigation of lysosomal enzyme activities in the aortic endothelial cells of rats with renal hypertension. (6141660)
1983
32
Alterations in plasma and cerebrospinal fluid norepinephrine and angiotensin II during the development of renal hypertension in conscious dogs. (6337956)
1983
33
Renal hypertension: physiology, signs, and symptoms. (6556466)
1983
34
Combined captopril and spironolactone treatment in Conn's syndrome with renal impairment and refractory hypertension. (7014043)
1981
35
Experimental renal hypertension in pregnant sheep. II. Response to a one-kidney model. (7032300)
1981
36
Rare forms of renal hypertension. (7007720)
1981
37
Reversible renal failure in malignant hypertension. (7408261)
1980
38
Resolution of renal failure with malignant hypertension in scleroderma. Case report and review of the literature. (474603)
1979
39
Metaplastic and mitotic activity of the ischemic (endocrine) kidney in experimental renal hypertension. (474709)
1979
40
Neurogenic activity--angiotensin II interaction during the development and maintenance of renal hypertension in the rat. (477245)
1979
41
Prostaglandins in renovascular and renal hypertension. (699590)
1978
42
Peri-ureteric collateral vessels in rabbits with experimental renal hypertension. (926316)
1977
43
Letter: The hunt for renal hypertension. (56614)
1976
44
Renin-angiotensin-aldosterone system in experimental renal hypertension in the rabbit. (1259009)
1976
45
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. (234677)
1975
46
The clinical picture of renal hypertension. (1192621)
1975
47
Experimental renal hypertension in rats. (1184305)
1975
48
The inhibition of angiotensin converting enzyme in chronic renal hypertension by a synthetic peptide. (174133)
1975
49
The effect of synthetic peptide on chronic renal hypertension in the rat. (4353878)
1973
50
Plasma renin activity in the rabbit with renal hypertension. (4331051)
1971

Genetic Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for genes affiliated with Renal Hypertension

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51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Renal Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0EDN1
2
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9.2ACE, REN
3
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8.7ACE, REN, KNG1

Compounds for genes affiliated with Renal Hypertension

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience
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Compounds related to Renal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1ornipressin449.5ALB, REN
2potassium chloride44 1110.4EDN1, KNG1, REN
3papaverine44 2 1111.2EDN1, KNG1, EPO
4thiazide449.2REN, ACE, SLC12A3
5zofenoprilat449.1KNG1, ACE
6perindoprilat449.1KNG1, REN, ACE
7cilazapril44 1110.1KNG1, ACE, EDN1
8chymostatin449.1ACE, EDN1, REN
9indapamide44 1110.1REN, ALB, ACE
10saralasin449.1ACE, REN, KNG1
11eprosartan44 28 1111.1REN, KNG1, ACE
12fosinopril44 1110.1REN, ACE, ALB
13isosorbide dinitrate44 49 1111.0KNG1, EDN1, ACE
14moexiprilat449.0KNG1, ACE
15polysulfone449.0EPO, ALB, KNG1
16dihydropyridine449.0ACE, EDN1, REN
17telmisartan44 28 1111.0REN, ACE, ALB
18irbesartan44 28 49 1112.0ALB, REN, ACE
19thiorphan44 28 1111.0KNG1, EDN1, ACE
20amlodipine44 49 11 2411.9ALB, REN, ACE
21an 69448.9KNG1, EPO, ACE
22spironolactone49 44 59 28 1112.9REN, ALB, ACE
23carvedilol44 49 28 1111.9EDN1, REN, ACE
24capoten448.8KNG1, ACE
25phosphoramidon44 119.8EDN1, ACE, KNG1
26hydrochlorothiazide44 49 28 11 2412.8ACE, ALB, REN, SLC12A3
27furosemide44 49 59 28 11 2413.7REN, ACE, ALB, SLC12A3
28lacidipine448.7EDN1, KNG1, REN, ACE
29omapatrilat448.7EDN1, KNG1, REN, ACE
30trandolapril44 119.7EDN1, KNG1, REN, ACE
31quinapril44 119.7EDN1, KNG1, REN, ACE
32enalaprilat448.7KNG1, EDN1, REN, ACE
33valsartan44 59 28 1111.7ACE, ALB, REN, EDN1
34diltiazem44 28 1110.7EDN1, KNG1, REN, ACE
35nitroglycerin44 119.7ACE, EDN1, REN, KNG1
36ang ii448.7REN, KNG1, ACE, EDN1
37lisinopril44 11 2410.6KNG1, ACE, REN, ALB
38ramipril44 119.6REN, ALB, ACE, KNG1
39perindopril44 49 1110.6REN, KNG1, ALB, ACE
40candesartan44 28 1110.6KNG1, REN, ACE, ALB
41verapamil44 49 28 11 2412.6EDN1, KNG1, REN, ACE
42kininogen448.6ALB, KNG1, REN, ACE
43nifedipine44 49 28 1111.6ACE, REN, EDN1, KNG1
44prostacyclin448.5ACE, EDN1, KNG1, REN
45captopril44 28 49 59 1112.2ALB, REN, KNG1, EDN1, ACE
46potassium44 11 2410.2ACE, KNG1, ALB, SLC12A3, REN
47losartan44 49 28 1111.2EDN1, REN, KNG1, ACE, ALB
48creatinine447.9REN, ACE, EPO, ALB, EDN1
49sodium44 248.8ACE, SLC12A3, REN, KNG1, ALB, EDN1
50enalapril44 49 119.6ACE, ALB, EPO, KNG1, EDN1, REN

GO Terms for genes affiliated with Renal Hypertension

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16Gene Ontology
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Cellular components related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, KNG1
2extracellular spaceGO:0056157.0ALB, ACE, REN, EPO, KNG1, EDN1
3extracellular regionGO:0055766.8EDN1, KNG1, EPO, REN, ACE, ALB

Biological processes related to Renal Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of urine volumeGO:0358109.6KNG1, EDN1
2negative regulation of blood coagulationGO:0301959.5EDN1, KNG1
3positive regulation of renal sodium excretionGO:0358159.4KNG1, EDN1
4response to testosterone stimulusGO:0335749.4EPO, EDN1
5angiotensin maturationGO:0020039.4ACE, REN
6response to lipopolysaccharideGO:0324969.1REN, EPO, EDN1
7regulation of vasoconstrictionGO:0192298.9ACE, EDN1

Products for genes affiliated with Renal Hypertension

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  • Antibodies
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Sources for Renal Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet