MCID: RNL015
MIFTS: 46

Renal Hypertension

Categories: Rare diseases, Nephrological diseases, Cardiovascular diseases, Ear diseases, Genetic diseases

Aliases & Classifications for Renal Hypertension

MalaCards integrated aliases for Renal Hypertension:

Name: Renal Hypertension 12 72 14 69
Hypertension, Renal 41
Hypertension Renal 51

Classifications:



External Ids:

Disease Ontology 12 DOID:1073
MeSH 41 D006977
NCIt 46 C3121
SNOMED-CT 64 194775007 28119000
UMLS 69 C0020544

Summaries for Renal Hypertension

MalaCards based summary : Renal Hypertension, also known as hypertension, renal, is related to renovascular hypertension and hypertensive encephalopathy. An important gene associated with Renal Hypertension is EDN1 (Endothelin 1), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Renin secretion. The drugs Amlodipine and Amlodipine, atorvastatin drug combination have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Renovascular hypertension (or \"renal hypertension\") is a condition in which high blood pressure is... more...

Related Diseases for Renal Hypertension

Diseases in the Renal Hypertension family:

Renal Failure, Progressive, with Hypertension

Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 158)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.9 ACE ADM AGTR1 EDN1 REN
2 hypertensive encephalopathy 29.8 ACE EPO
3 renal tuberculosis 29.7 EDN1 REN
4 arteriosclerosis 29.3 ACE ADM EDN1
5 diastolic heart failure 29.2 ACE AGTR1 NPPB
6 vascular disease 28.9 ACE EDN1 KNG1 REN
7 malignant hypertension 28.4 ACE ADM AGTR1 EDN1 REN
8 kidney disease 28.3 ACE AGTR1 ALB EDN1 EPO NPPB
9 chronic kidney failure 27.9 ACE AGTR1 ALB EDN1 EPO NPPB
10 arteries, anomalies of 27.7 ACE AGTR1 ALB EDN1 KNG1 NPPB
11 hypertension, essential 25.1 ACE ADM AGTR1 ALB DBH EDN1
12 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis syndrome 12.4
13 malignant hypertensive renal disease 12.1
14 benign hypertensive renal disease 12.0
15 renal failure, progressive, with hypertension 11.1
16 polycystic kidney disease 4 with or without hepatic disease 10.8
17 polycystic kidney disease 3 10.8
18 chronic thromboembolic pulmonary hypertension 10.5 EDN1 NPPB
19 malignant renovascular hypertension 10.5 EDN1 REN
20 constrictive pericarditis 10.5 ALB NPPB
21 splenic disease 10.4 ALB EPO
22 benign essential hypertension 10.4 ALB REN
23 perinephritis 10.4 EDN1 REN
24 chronic angina 10.4 NPPB REN
25 kidney papillary necrosis 10.4 ALB REN
26 fetal erythroblastosis 10.4 ALB EPO
27 tricuspid valve insufficiency 10.4 ALB NPPB
28 pure red-cell aplasia 10.4 ALB EPO
29 hypersplenism 10.4 ALB EPO
30 arthrogryposis, distal, type 3 10.4 REN SLC12A3
31 anterolateral myocardial infarction 10.4 ACE NPPB
32 rh isoimmunization 10.4 ALB EPO
33 cardiac tamponade 10.4 NPPB REN
34 hyporeninemic hypoaldosteronism 10.4 ACE REN
35 analbuminemia 10.4 ALB EPO
36 renal artery obstruction 10.3 ACE REN
37 hypertension, diastolic 10.3 ACE REN
38 hypoaldosteronism 10.3 ACE REN
39 atrial septal defect 4 10.3 ACE REN
40 hypertensive retinopathy 10.3 ACE REN
41 aortic valve insufficiency 10.3 ACE NPPB
42 secondary hyperparathyroidism of renal origin 10.3 ALB EPO
43 coronary artery vasospasm 10.3 EDN1 KNG1
44 diffuse scleroderma 10.3 EDN1 KNG1
45 chronic mountain sickness 10.3 EDN1 EPO NPPB
46 ischemic heart disease 10.3 ACE NPPB
47 hepatic vascular disease 10.3 ALB EDN1 REN
48 systolic heart failure 10.3 ACE NPPB
49 sexual disorder 10.3 ACE EDN1
50 raynaud disease 10.3 AGTR1 EDN1

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to Renal Hypertension

Symptoms & Phenotypes for Renal Hypertension

MGI Mouse Phenotypes related to Renal Hypertension:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 ACE ADM AGTR1 DBH EDN1 EPO
2 homeostasis/metabolism MP:0005376 9.65 ACE ADM AGTR1 ALB DBH EDN1
3 renal/urinary system MP:0005367 9.17 ACE ADM AGTR1 ALB EDN1 REN

Drugs & Therapeutics for Renal Hypertension

Drugs for Renal Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amlodipine Approved 88150-42-9 2162
2 Amlodipine, atorvastatin drug combination
3 Anticholesteremic Agents
4 Antihypertensive Agents
5 Antimetabolites
6 Atorvastatin Calcium 134523-03-8
7 calcium channel blockers
8 Calcium, Dietary
9 Hydroxymethylglutaryl-CoA Reductase Inhibitors
10 Hypolipidemic Agents
11 Lipid Regulating Agents
12 Vasodilator Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Electroacupuncture for Hypertension Patients With Chronic Kidney Disease Completed NCT01766427
2 Amlodipine/Atorvastatin (Caduet®) Drug Use Investigation (Regulatory Post Marketing Commitment Plan) Completed NCT01107743 Amlodipine/Atorvastatin
3 Renal Denervation in Treatment Resistant Hypertension Recruiting NCT01687725
4 Renal Nerve Ablation in Chronic Kidney Disease Patients Recruiting NCT01442883
5 Prevalence of Resistant Hypertension With DOT Active, not recruiting NCT02513524

Search NIH Clinical Center for Renal Hypertension

Cochrane evidence based reviews: hypertension, renal

Genetic Tests for Renal Hypertension

Anatomical Context for Renal Hypertension

MalaCards organs/tissues related to Renal Hypertension:

38
Kidney, Heart, Brain, Testes, Endothelial, Smooth Muscle, Cortex

Publications for Renal Hypertension

Articles related to Renal Hypertension:

(show top 50) (show all 512)
# Title Authors Year
1
Flax lignan concentrate reverses alterations in blood pressure, left ventricular functions, lipid profile and antioxidant status in DOCA-salt induced renal hypertension in rats. ( 26795298 )
2016
2
The cardioprotective effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension. ( 25920277 )
2015
3
The effects of resveratrol in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 25821295 )
2015
4
Hydroalcoholic extract of Allium eriophyllum leaves attenuates cardiac impairment in rats with simultaneous type 2 diabetes and renal hypertension. ( 26487889 )
2015
5
Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. ( 25097277 )
2014
6
Renal hypertension and cardiovascular disorder in children with chronic kidney disease. ( 24684043 )
2014
7
Effects of oleuropein in rats with simultaneous type 2 diabetes and renal hypertension: a study of antihypertensive mechanisms. ( 24954237 )
2014
8
Curable renal hypertension: renin, marker or cause? Question answered. ( 25103928 )
2014
9
Editorial (thematic issue: all roads of renal hypertension lead to or come from CKD). ( 25549836 )
2014
10
Renal denervation for resistant hypertension using an irrigated radiofrequency balloon: 12-month results from the Renal Hypertension Ablation System (RHAS) trial. ( 23685297 )
2013
11
Renal hypertension: an unusual cause for a common problem. ( 23371394 )
2013
12
Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats. ( 22458508 )
2012
13
ESPR uroradiology task force and ESUR paediatric working group: imaging recommendations in paediatric uroradiology, part IV: Minutes of the ESPR uroradiology task force mini-symposium on imaging in childhood renal hypertension and imaging of renal trauma in children. ( 21710387 )
2011
14
Effect of age and sex on blood pressure, development of renal hypertension, and concentration of nitric oxide in the blood of albino rats. ( 21113443 )
2010
15
Comprehensive evaluation of patients with suspected renal hypertension using MDCT: from protocol to interpretation. ( 19380531 )
2009
16
Effectiveness of unilateral nephrectomy for renal hypertension in adults. ( 19010760 )
2008
17
Cardiovascular reactivity in patients with essential or renal hypertension under standardized mental stress. ( 17653965 )
2007
18
Cardiovascular reactivity of patients with essential and renal hypertension in an emotion-triggering interview. ( 17348427 )
2007
19
Total peripheral resistance responsiveness during the development of secondary renal hypertension in dogs. ( 17278982 )
2007
20
Renal capsular PEComa--a rare cause of surgically correctable renal hypertension. ( 17318350 )
2007
21
Correction of renal hypertension after kidney transplantation from a donor with Gitelman syndrome. ( 16479187 )
2006
22
Water intake during the development of renal hypertension (2K-1C) in mice. ( 15992836 )
2005
23
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 15711357 )
2005
24
Ventricular structure and function in aged dogs with renal hypertension: a model of experimental diastolic heart failure. ( 15723971 )
2005
25
Cardiovascular hypertrophy in one-kidney, one-clip renal hypertension is resistant to heparin. ( 15126919 )
2004
26
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. ( 14678186 )
2004
27
The role of partial nephrectomy in the treatment of pediatric renal hypertension. ( 12544329 )
2003
28
[Clinical observation of the therapeutic effect of valsartan for renal hypertension in 64 cases]. ( 13129740 )
2003
29
Mild renal hypertension alters run training effects on the frequency response of rat cardiomyocyte mechanics. ( 12857770 )
2003
30
Mouse model of cerebral aneurysm: experimental induction by renal hypertension and local hemodynamic changes. ( 12105374 )
2002
31
Sympathetic nervous system function in renal hypertension. ( 12003706 )
2002
32
Neurohormonal influences on maintenance and reversal of two-kidney one-clip renal hypertension. ( 12100364 )
2002
33
Neurogenic factors in renal hypertension. ( 12003710 )
2002
34
Factors influencing acute ischaemia-induced renal hypertension in rats. ( 12473871 )
2002
35
Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats. ( 11356766 )
2001
36
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. ( 11566905 )
2001
37
Altered contractions to endothelin-1, phenylephrine, potassium chloride and relaxations to acetylcholine at various stages of renal hypertension in the rat. ( 11401413 )
2001
38
Plasma-levels of endothelin-1 and angiotensin-II and reactivity of arterial blood pressure to exogenous sympathomimetics and vasoactive peptides in rat model of malignant renal hypertension. ( 10870254 )
2000
39
Poland's syndrome--complicated with renal hypertension. ( 11273191 )
2000
40
Acute AT1 receptor blockade does not improve the depressed baroreflex in rats with chronic renal hypertension. ( 11105103 )
2000
41
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. ( 10666094 )
2000
42
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. ( 10706380 )
2000
43
[The protection of renal function in the ACEI treatment of renal hypertension]. ( 12206011 )
2000
44
Effect of ramipril on ambulatory blood pressure and albuminuria in renal hypertension. ( 11095026 )
2000
45
Plasma brain natriuretic peptides and renal hypertension. ( 10955934 )
2000
46
[Study on the relationship between plasma endothelin nitric oxide concentration and renal hypertension and renal function]. ( 12080656 )
1999
47
Serial magnetic resonance imaging of rat brain after induction of renal hypertension. ( 10548682 )
1999
48
How reproducible is diurnal blood pressure rhythm in patients with secondary (renal) hypertension? ( 10756891 )
1999
49
Decreased diurnal blood pressure variability and low dehydroepiandrosterone sulfate levels in patients with renal hypertension, and after kidney transplantation. ( 10463206 )
1999
50
Renal hypertension due to giant perirenal haematoma: permanent resolution by percutaneous ultrasound-guided drainage. ( 9561580 )
1998

Variations for Renal Hypertension

Expression for Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for Renal Hypertension

GO Terms for Renal Hypertension

Cellular components related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ACE ADM ALB DBH EDN1 EPO
2 extracellular space GO:0005615 9.32 ACE ADM ALB DBH EDN1 EPO

Biological processes related to Renal Hypertension according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.88 ADM EDN1 EPO NPPB
2 response to hypoxia GO:0001666 9.77 ADM EDN1 EPO
3 response to lipopolysaccharide GO:0032496 9.71 ADM EDN1 EPO REN
4 kidney development GO:0001822 9.69 ACE AGTR1 REN
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 ADM AGTR1 EDN1 KNG1
6 response to testosterone GO:0033574 9.61 EDN1 EPO
7 blood vessel remodeling GO:0001974 9.61 ACE DBH
8 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.6 AGTR1 EDN1
9 positive regulation of heart rate GO:0010460 9.58 ADM EDN1
10 blood coagulation, intrinsic pathway GO:0007597 9.57 KLKB1 KNG1
11 negative regulation of blood coagulation GO:0030195 9.56 EDN1 KNG1
12 amyloid-beta metabolic process GO:0050435 9.55 ACE REN
13 positive regulation of renal sodium excretion GO:0035815 9.54 EDN1 NPPB
14 positive regulation of urine volume GO:0035810 9.52 EDN1 NPPB
15 response to dexamethasone GO:0071548 9.49 EDN1 EPO
16 angiotensin maturation GO:0002003 9.48 ACE REN
17 body fluid secretion GO:0007589 9.46 EDN1 NPPB
18 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 ACE AGTR1
19 regulation of vasoconstriction GO:0019229 9.43 ACE AGTR1 EDN1
20 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGTR1 REN
21 regulation of blood vessel size GO:0050880 9.33 EDN1 KNG1 NPPB
22 regulation of blood vessel diameter GO:0097746 9.13 ACE AGTR1 NPPB
23 regulation of blood pressure GO:0008217 8.92 ACE EDN1 NPPB REN

Molecular functions related to Renal Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 ADM EDN1 KNG1 NPPB REN
2 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
3 hormone activity GO:0005179 8.92 ADM EDN1 EPO NPPB

Sources for Renal Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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