MCID: RNL015
MIFTS: 61

Renal Hypertension malady

Cardiovascular diseases, Nephrological diseases categories
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Summaries for Renal Hypertension

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Wikipedia:65 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards based summary: Renal Hypertension, also known as hypertensive disease, is related to hypertension and gitelman syndrome. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drugs acebutolol and amiloride and the compounds ornipressin and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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Sources:
8Disease Ontology, 62UMLS, 44Novoseek, 57SNOMED-CT, 39NCIt, 34MeSH
See all sources

Renal Hypertension, Aliases & Descriptions:

Name: Renal Hypertension 8 62
Hypertensive Disease 62
 
Hypertension Renal 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Nephrological diseases


External Ids:

Disease Ontology8 DOID:1073
NCIt39 C3121
SNOMED-CT57 28119000, 194775007
MeSH34 D006977

Related Diseases for Renal Hypertension

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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.2ACE, REN, ALB, EDN1, SLC12A3
2gitelman syndrome30.3REN, SLC12A3
3renovascular hypertension30.3ACE, REN
4renal tubular dysgenesis30.1ACE, REN
5malignant hypertension30.1REN, ACE
6uremia30.0EPO, ALB
7hypertensive nephropathy30.0ACE, ALB
8liver cirrhosis29.9REN, EDN1, ALB
9proteinuria29.6REN, ACE, ALB, EDN1
10essential hypertension29.1ACE, EDN1, SLC12A3, ALB, REN
11fibromuscular dysplasia10.5REN
12hypoaldosteronism10.5REN
13congestive heart failure10.4REN
14malignant hypertensive renal disease10.4
15hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
16oligohydramnios10.3ACE
17anuria10.3ACE
18neuronitis10.3
19benign hypertensive renal disease10.3
20bartter syndrome type 310.3SLC12A3, REN
21pseudohypoaldosteronism type ii10.3REN, SLC12A3
22bartter disease10.3SLC12A3, REN
23pseudohypoaldosteronism10.3REN, SLC12A3
24cerebritis10.2
25ovarian hyperstimulation syndrome10.2REN, ALB
26low renin hypertension10.2EDN1, REN
27hepatopulmonary syndrome10.2EDN1, ALB
28acute kidney failure10.2ALB, REN
29portal hypertension10.2ALB, EDN1
30kidney disease10.2
31endotheliitis10.2
32metabolic acidosis10.2REN, ALB
33primary hyperoxaluria10.1REN, SLC12A3
34secondary hyperparathyroidism of renal origin10.1ALB, EPO
35hypertension, diastolic10.1ACE, REN
36hyperparathyroidism10.1EPO, ALB
37sickle cell disease10.1EPO, EDN1
38pulmonary hypertension10.1
39renal cell carcinoma10.1
40polycystic kidney disease10.1
41congenital mesoblastic nephroma10.1
42aneurysm10.1
43mesoblastic nephroma10.1
44renal artery disease10.1ACE, ALB
45idiopathic edema10.1EDN1, ACE
46peripheral vascular disease10.1ACE, ALB
47polycystic kidney disease, autosomal dominant10.1ACE, REN
48focal segmental glomerulosclerosis10.0ALB, ACE
49hepatorenal syndrome10.0EDN1, ALB, REN
50cork-handlers' disease10.0ALB, ACE

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Symptoms for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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MalaCards organs/tissues related to Renal Hypertension:

32
Kidney, Heart, Brain, Testes, Endothelial, Cortex, Smooth muscle, Thymus, Retina, Pancreas, Thyroid, Adrenal gland, Placenta, Hypothalamus, Medulla oblongata, Cardiac myocytes, Adrenal cortex

Animal Models for Renal Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Renal Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1EDN1, EPO, REN, ALB
2MP:00053677.8EDN1, REN, ACE, ALB, SLC12A3
3MP:00053857.5EDN1, EPO, REN, ACE, SLC12A3
4MP:00107687.5EDN1, EPO, REN, ACE, ALB
5MP:00053767.1ACE, REN, EPO, EDN1, ALB, SLC12A3

Publications for Renal Hypertension

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Articles related to Renal Hypertension:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. (25097277)
2014
2
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
3
Neurogenic factors in renal hypertension. (12003710)
2002
4
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. (10666094)
2000
5
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. (10706380)
2000
6
Vasoactive intestinal contractor as a genesis of renal hypertension. (7723902)
1995
7
Mechanisms of renal hypertension and renal contribution to primary hypertension. (8116014)
1993
8
Characteristics of arterial myosin in experimental renal hypertension in the dog. (8491497)
1993
9
Sustained release verapamil in renal hypertension. (2966736)
1988
10
Sepsis and death after embolization of host kidneys in a resistant renal hypertension transplanted patient. (3050575)
1988
11
Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. (2974250)
1988
12
Changes of the intrinsic heart rate during the onset of renal hypertension. (3429876)
1987
13
Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: myosin, myosin ATPase and collagen. (2951526)
1987
14
Different cation transport inhibitor in benign and malignant experimental renal hypertension. (3794332)
1986
15
Experimental basis of angioinfarction for the treatment of renal hypertension. (2938325)
1986
16
Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat. (3024889)
1986
17
Cardiovascular and hormonal effects of clonidine in patients with essential hypertension and renal hypertension. (3913757)
1985
18
Effect of l-p-tyrosine on the development of renal hypertension in rats. (4048261)
1985
19
Post traumatic renal hypertension. (6383316)
1984
20
Contrasting effects of the renin-angiotensin system on renal function disclosed during converting enzyme inhibition in patients with renal hypertension. (6089319)
1984
21
Renal vein renin on acute stimulation in diagnosis of renal hypertension. (6367378)
1983
22
Baroreceptor function during natural sleep in rats with mild and severe renal hypertension. (7182026)
1982
23
Renal venous renin activity in various forms of curable renal hypertension. (7018775)
1981
24
Transmembrane action potentials and the electrocardiogram in rats with renal hypertension. (6459847)
1981
25
Experimental renal hypertension in pregnant sheep. II. Response to a one-kidney model. (7032300)
1981
26
Cardiomyopathy produced in rats with acute renal hypertension. (7354229)
1980
27
Effect of dietary salt on hemodynamics of established renal hypertension in the rabbit. Implications for the autoregulation theory of hypertension. (7007237)
1980
28
On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. (477821)
1979
29
Prostaglandins in renovascular and renal hypertension. (699590)
1978
30
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
31
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977
32
Dose response of SQ 20, 858 in chronic renal hypertension. (194265)
1977
33
The pathophysiology of renal hypertension. (271507)
1977
34
Renal kallikrein system, volemia, and renal hypertension. (875470)
1977
35
Unusual problems in renal hypertension. (1262150)
1976
36
Norepinephrine infusion in normal subjects and patients with essential or renal hypertension: effect on blood pressure, heart rate, and plasma catecholamine concentrations. (943425)
1976
37
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
38
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975
39
Role of angiotensin II in experimental renal hypertension in the rabbit. (1146999)
1975
40
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. (234677)
1975
41
Sympathetic influence on vascular smooth muscle contractility in renal hypertension in the rabbit. (1226729)
1975
42
Proceedings: Effect of chronic oral administration of propranolol on spontaneously and renal hypertension rats. (1160179)
1975
43
Salt appetite during the early phase of renal hypertension in rats. (1171438)
1975
44
Proceedings: Effects of removal of endocrine organs on spontaneous and renal hypertension in rats. (4546178)
1974
45
Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. (4275703)
1974
46
The effect on renal hypertension of subcutaneous isotransplantation of renal medulla from normal or hypertensive rats. Including studies on spontaneous variations in blood pressure in normal and hypertensive rats. (4589285)
1973
47
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance. (5084880)
1972
48
Modification of thyroid activity during development of experimental renal hypertension in rats. (5570560)
1971
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Effect of sodium diethyldithiocarbamate (DDC) on renal hypertension in rats. (5353264)
1969

Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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Expression patterns in normal tissues for genes affiliated with Renal Hypertension

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Pathways for genes affiliated with Renal Hypertension

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Compounds for genes affiliated with Renal Hypertension

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Compounds related to Renal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ornipressin449.8ALB, REN
2toki-shakuyaku-san449.8EDN1, REN
3darusentan44 2810.6EDN1, REN
4eprex449.5EPO, ALB
551-cr-edta449.5REN, ALB
6ibopamine449.5ACE, REN
7sampatrilat449.5REN, ACE
8remikiren44 1110.4REN, ACE
9perindoprilat449.4REN, ACE
10alacepril449.3ACE, REN
11midodrine44 1110.3ALB, EPO
12aliskiren44 1110.3ACE, REN
13thiazide449.2SLC12A3, REN, ACE
14lacidipine449.1REN, EDN1, ACE
15indapamide44 1110.1ALB, ACE, REN
16cilazapril44 1110.1REN, EDN1, ACE
17trandolapril44 1110.1REN, EDN1, ACE
18omapatrilat449.1EDN1, REN, ACE
19bucindolol44 5010.1ACE, REN
20celecoxib44 61 28 50 24 1114.1ALB, EPO, REN
21fosinopril44 1110.1REN, ALB, ACE
22quinapril44 50 1111.1EDN1, REN, ACE
23enalaprilat449.1ACE, EDN1, REN
24lisinopril44 50 24 1112.1REN, ACE, ALB
25ramipril44 1110.1REN, ACE, ALB
26chymostatin449.1ACE, REN, EDN1
27hydralazine44 50 1111.1ACE, REN, EDN1
28perindopril44 50 1111.1ALB, ACE, REN
29telmisartan44 28 1111.1REN, ACE, ALB
30atenolol44 50 28 24 1113.0ACE, REN, EDN1
31dihydropyridine449.0REN, EDN1, ACE
32diltiazem44 28 50 1112.0EDN1, REN, ACE
33candesartan44 50 28 1112.0ALB, ACE, REN
34amlodipine44 50 24 1112.0ALB, ACE, REN
35spironolactone44 61 28 50 1113.0ALB, ACE, REN
36carvedilol44 50 28 1112.0REN, ACE, EDN1
37nitroglycerin44 1110.0EDN1, REN, ACE
38ang ii449.0ACE, REN, EDN1
39kininogen449.0ALB, ACE, REN
40dihydralazine448.9REN, ACE
41hydrochlorothiazide44 28 50 24 1112.7ACE, REN, ALB, SLC12A3
42furosemide44 61 28 50 24 1113.7REN, ACE, ALB, SLC12A3
43valsartan44 61 28 1111.6EDN1, REN, ACE, ALB
44irbesartan44 28 50 1111.6ACE, REN, ALB, EDN1
45captopril44 61 50 28 1112.6EDN1, REN, ACE, ALB
46losartan44 50 28 1111.6EDN1, REN, ACE, ALB
47potassium44 24 1110.6ALB, REN, ACE, SLC12A3
48sodium44 249.2SLC12A3, ALB, REN, EDN1, ACE
49enalapril44 50 1110.0ALB, ACE, REN, EPO, EDN1
50creatinine447.9EDN1, EPO, REN, ACE, ALB

GO Terms for genes affiliated with Renal Hypertension

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Cellular components related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5EPO, REN, ACE, ALB, EDN1
2extracellular spaceGO:0056157.2ALB, ACE, REN, EPO, EDN1

Biological processes related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.3ACE, REN
2response to testosteroneGO:0335749.2EPO, EDN1
3kidney developmentGO:0018229.2ACE, REN
4regulation of vasoconstrictionGO:0192299.1EDN1, ACE
5response to lipopolysaccharideGO:0324969.0REN, EPO, EDN1
6regulation of blood pressureGO:0082178.9ACE, REN

Molecular functions related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3EPO, EDN1
2drug bindingGO:0081448.8ALB, ACE

Products for genes affiliated with Renal Hypertension

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  • Antibodies
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Sources for Renal Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet