MCID: RNL015
MIFTS: 60

Renal Hypertension malady

Cardiovascular diseases, Nephrological diseases categories
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Summaries for Renal Hypertension

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65Wikipedia, 33MalaCards
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Wikipedia:65 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renal Hypertension, also known as hypertensive disease, is related to hypertension and renovascular hypertension. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drugs acebutolol and amiloride and the compounds ornipressin and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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8Disease Ontology, 62UMLS, 45Novoseek, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Nephrological diseases


Aliases & Descriptions:

renal hypertension 8 62
hypertensive disease 62
hypertension renal 45


External Ids:

Disease Ontology8 DOID:1073
MeSH35 D006977
SNOMED-CT58 28119000, 194775007
NCIt40 C3121

Related Diseases for Renal Hypertension

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17GeneCards, 18GeneDecks
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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.7SLC12A3, ALB, ACE, REN, EDN1
2renovascular hypertension30.1ACE, REN
3proteinuria30.0ALB, ACE, REN, EDN1
4gitelman syndrome30.0REN, SLC12A3
5malignant hypertension29.9REN, ACE
6renal tubular dysgenesis29.9REN, ACE
7uremia29.9ALB, EPO
8hypertensive nephropathy29.9ACE, ALB
9essential hypertension29.7EDN1, REN, ACE, ALB, SLC12A3
10malignant hypertensive renal disease10.4
11hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
12neuronitis10.3
13benign hypertensive renal disease10.3
14cerebritis10.2
15endotheliitis10.2
16hypoaldosteronism10.1REN
17fibromuscular dysplasia10.1REN
18congestive heart failure10.1REN
19oligohydramnios10.1ACE
20polycystic kidney disease10.1
21congenital mesoblastic nephroma10.1
22kidney disease10.1
23renal cell carcinoma10.1
24aneurysm10.1
25mesoblastic nephroma10.1
26anuria10.1ACE
27pseudohypoaldosteronism type ii10.1REN, SLC12A3
28bartter syndrome type 310.1REN, SLC12A3
29bartter disease10.1SLC12A3, REN
30pseudohypoaldosteronism10.1REN, SLC12A3
31ovarian hyperstimulation syndrome10.1REN, ALB
32low renin hypertension10.0EDN1, REN
33hepatopulmonary syndrome10.0EDN1, ALB
34acute kidney failure10.0ALB, REN
35portal hypertension10.0EDN1, ALB
36metabolic acidosis10.0ALB, REN
37primary hyperoxaluria10.0REN, SLC12A3
38secondary hyperparathyroidism of renal origin10.0ALB, EPO
39hypertension, diastolic10.0REN, ACE
40hyperparathyroidism10.0ALB, EPO
41sickle cell disease10.0EDN1, EPO
42renal artery disease10.0ACE, ALB
43idiopathic edema10.0EDN1, ACE
44peripheral vascular disease10.0ACE, ALB
45polycystic kidney disease, autosomal dominant10.0ACE, REN
46focal segmental glomerulosclerosis10.0ALB, ACE
47hepatorenal syndrome10.0ALB, REN, EDN1
48cork-handlers' disease10.0ALB, ACE
49erythrocytosis10.0EPO, ACE
50liver cirrhosis10.0EDN1, REN, ALB

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Symptoms for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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33MalaCards
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MalaCards organs/tissues related to Renal Hypertension:

33
Kidney, Heart, Brain, Testes, Endothelial, Smooth muscle, Cortex, Cardiac myocytes, Medulla oblongata, Hypothalamus, Thymus, Placenta, Adrenal gland, Thyroid, Pancreas, Retina, Adrenal cortex

Animal Models for Renal Hypertension or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Renal Hypertension:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1EDN1, EPO, REN, ALB
2MP:00053677.8SLC12A3, ALB, ACE, REN, EDN1
3MP:00053857.5EDN1, EPO, REN, ACE, SLC12A3
4MP:00107687.5ALB, ACE, REN, EPO, EDN1
5MP:00053767.1EDN1, EPO, REN, ACE, ALB, SLC12A3

Publications for Renal Hypertension

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52PubMed
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Articles related to Renal Hypertension:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
2
Neurogenic factors in renal hypertension. (12003710)
2002
3
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. (10666094)
2000
4
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. (10706380)
2000
5
Vasoactive intestinal contractor as a genesis of renal hypertension. (7723902)
1995
6
Mechanisms of renal hypertension and renal contribution to primary hypertension. (8116014)
1993
7
Characteristics of arterial myosin in experimental renal hypertension in the dog. (8491497)
1993
8
Sustained release verapamil in renal hypertension. (2966736)
1988
9
Sepsis and death after embolization of host kidneys in a resistant renal hypertension transplanted patient. (3050575)
1988
10
Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. (2974250)
1988
11
Changes of the intrinsic heart rate during the onset of renal hypertension. (3429876)
1987
12
Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: myosin, myosin ATPase and collagen. (2951526)
1987
13
Different cation transport inhibitor in benign and malignant experimental renal hypertension. (3794332)
1986
14
Experimental basis of angioinfarction for the treatment of renal hypertension. (2938325)
1986
15
Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat. (3024889)
1986
16
Cardiovascular and hormonal effects of clonidine in patients with essential hypertension and renal hypertension. (3913757)
1985
17
Effect of l-p-tyrosine on the development of renal hypertension in rats. (4048261)
1985
18
Post traumatic renal hypertension. (6383316)
1984
19
Contrasting effects of the renin-angiotensin system on renal function disclosed during converting enzyme inhibition in patients with renal hypertension. (6089319)
1984
20
Baroreceptor function during natural sleep in rats with mild and severe renal hypertension. (7182026)
1982
21
Renal venous renin activity in various forms of curable renal hypertension. (7018775)
1981
22
Transmembrane action potentials and the electrocardiogram in rats with renal hypertension. (6459847)
1981
23
Experimental renal hypertension in pregnant sheep. II. Response to a one-kidney model. (7032300)
1981
24
Renal hypertension secondary to ureteropelvis junction obstruction. Unusual presentation and new therapeutic modality. (7456201)
1981
25
Cardiomyopathy produced in rats with acute renal hypertension. (7354229)
1980
26
Effect of dietary salt on hemodynamics of established renal hypertension in the rabbit. Implications for the autoregulation theory of hypertension. (7007237)
1980
27
On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. (477821)
1979
28
Prostaglandins in renovascular and renal hypertension. (699590)
1978
29
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
30
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977
31
Dose response of SQ 20, 858 in chronic renal hypertension. (194265)
1977
32
The pathophysiology of renal hypertension. (271507)
1977
33
Renal kallikrein system, volemia, and renal hypertension. (875470)
1977
34
Unusual problems in renal hypertension. (1262150)
1976
35
Norepinephrine infusion in normal subjects and patients with essential or renal hypertension: effect on blood pressure, heart rate, and plasma catecholamine concentrations. (943425)
1976
36
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
37
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975
38
Role of angiotensin II in experimental renal hypertension in the rabbit. (1146999)
1975
39
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. (234677)
1975
40
Sympathetic influence on vascular smooth muscle contractility in renal hypertension in the rabbit. (1226729)
1975
41
Proceedings: Effect of chronic oral administration of propranolol on spontaneously and renal hypertension rats. (1160179)
1975
42
Salt appetite during the early phase of renal hypertension in rats. (1171438)
1975
43
Proceedings: Effects of removal of endocrine organs on spontaneous and renal hypertension in rats. (4546178)
1974
44
Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. (4275703)
1974
45
The effect on renal hypertension of subcutaneous isotransplantation of renal medulla from normal or hypertensive rats. Including studies on spontaneous variations in blood pressure in normal and hypertensive rats. (4589285)
1973
46
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance. (5084880)
1972
47
Modification of thyroid activity during development of experimental renal hypertension in rats. (5570560)
1971
48
Metabolism of renal cortex in ischemic renal hypertension. (5090359)
1971
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Effect of sodium diethyldithiocarbamate (DDC) on renal hypertension in rats. (5353264)
1969

Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for genes affiliated with Renal Hypertension

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 51PharmGKB
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Compounds for genes affiliated with Renal Hypertension

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 51PharmGKB, 61Tocris Bioscience, 24HMDB
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Compounds related to Renal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ornipressin459.8ALB, REN
2toki-shakuyaku-san459.8EDN1, REN
3darusentan45 2910.6EDN1, REN
4eprex459.5EPO, ALB
551-cr-edta459.5REN, ALB
6ibopamine459.5ACE, REN
7sampatrilat459.5REN, ACE
8remikiren45 1110.4REN, ACE
9perindoprilat459.4REN, ACE
10alacepril459.3ACE, REN
11midodrine45 1110.3ALB, EPO
12aliskiren45 1110.3ACE, REN
13thiazide459.2SLC12A3, REN, ACE
14lacidipine459.1REN, EDN1, ACE
15indapamide45 1110.1ALB, ACE, REN
16cilazapril45 1110.1REN, EDN1, ACE
17trandolapril45 1110.1REN, EDN1, ACE
18omapatrilat459.1EDN1, REN, ACE
19bucindolol45 5110.1ACE, REN
20celecoxib45 61 29 51 24 1114.1ALB, EPO, REN
21fosinopril45 1110.1REN, ALB, ACE
22quinapril45 51 1111.1EDN1, REN, ACE
23enalaprilat459.1ACE, EDN1, REN
24lisinopril45 51 24 1112.1REN, ACE, ALB
25ramipril45 1110.1REN, ACE, ALB
26chymostatin459.1ACE, REN, EDN1
27hydralazine45 51 1111.1ACE, REN, EDN1
28perindopril45 51 1111.1ALB, ACE, REN
29telmisartan45 29 1111.1REN, ACE, ALB
30atenolol45 51 29 24 1113.0ACE, REN, EDN1
31dihydropyridine459.0REN, EDN1, ACE
32diltiazem45 29 51 1112.0EDN1, REN, ACE
33candesartan45 51 29 1112.0ALB, ACE, REN
34amlodipine45 51 24 1112.0ALB, ACE, REN
35spironolactone45 61 29 51 1113.0ALB, ACE, REN
36carvedilol45 51 29 1112.0REN, ACE, EDN1
37nitroglycerin45 1110.0EDN1, REN, ACE
38ang ii459.0ACE, REN, EDN1
39kininogen459.0ALB, ACE, REN
40dihydralazine458.9REN, ACE
41hydrochlorothiazide45 29 51 24 1112.7ACE, REN, ALB, SLC12A3
42furosemide45 61 29 51 24 1113.7REN, ACE, ALB, SLC12A3
43valsartan45 61 29 1111.6EDN1, REN, ACE, ALB
44irbesartan45 29 51 1111.6ACE, REN, ALB, EDN1
45captopril45 61 51 29 1112.6EDN1, REN, ACE, ALB
46losartan45 51 29 1111.6EDN1, REN, ACE, ALB
47potassium45 24 1110.6ALB, REN, ACE, SLC12A3
48sodium45 249.2SLC12A3, ALB, REN, EDN1, ACE
49enalapril45 51 1110.0ALB, ACE, REN, EPO, EDN1
50creatinine457.9EDN1, EPO, REN, ACE, ALB

GO Terms for genes affiliated with Renal Hypertension

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16Gene Ontology
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Cellular components related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5EPO, REN, ACE, ALB, EDN1
2extracellular spaceGO:0056157.2ALB, ACE, REN, EPO, EDN1

Biological processes related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.3ACE, REN
2response to testosteroneGO:0335749.2EPO, EDN1
3kidney developmentGO:0018229.2ACE, REN
4regulation of vasoconstrictionGO:0192299.1EDN1, ACE
5response to lipopolysaccharideGO:0324969.0REN, EPO, EDN1
6regulation of blood pressureGO:0082178.9ACE, REN

Molecular functions related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3EPO, EDN1
2drug bindingGO:0081448.8ALB, ACE

Products for genes affiliated with Renal Hypertension

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  • Antibodies
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Sources for Renal Hypertension

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet