MCID: RNL015
MIFTS: 60

Renal Hypertension malady

Cardiovascular diseases, Nephrological diseases categories

Summaries for Renal Hypertension

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66Wikipedia, 34MalaCards
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Wikipedia:66 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renal Hypertension, also known as hypertensive disease, is related to hypertension and renovascular hypertension. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The drugs acebutolol and amiloride and the compounds ornipressin and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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9Disease Ontology, 63UMLS, 46Novoseek, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Nephrological diseases


Aliases & Descriptions:

renal hypertension 9 63
hypertensive disease 63
hypertension renal 46


External Ids:

Disease Ontology9 DOID:1073
MeSH36 D006977
SNOMED-CT59 28119000, 194775007
NCIt41 C3121

Related Diseases for Renal Hypertension

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18GeneCards, 19GeneDecks
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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.7SLC12A3, ALB, ACE, REN, EDN1
2renovascular hypertension30.1ACE, REN
3proteinuria30.0ALB, ACE, REN, EDN1
4gitelman syndrome30.0REN, SLC12A3
5malignant hypertension29.9REN, ACE
6renal tubular dysgenesis29.9REN, ACE
7uremia29.9ALB, EPO
8hypertensive nephropathy29.9ACE, ALB
9essential hypertension29.7EDN1, REN, ACE, ALB, SLC12A3
10malignant hypertensive renal disease10.4
11hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
12neuronitis10.3
13benign hypertensive renal disease10.3
14cerebritis10.2
15endotheliitis10.2
16hypoaldosteronism10.1REN
17fibromuscular dysplasia10.1REN
18congestive heart failure10.1REN
19oligohydramnios10.1ACE
20polycystic kidney disease10.1
21congenital mesoblastic nephroma10.1
22kidney disease10.1
23renal cell carcinoma10.1
24aneurysm10.1
25mesoblastic nephroma10.1
26anuria10.1ACE
27pseudohypoaldosteronism type ii10.1REN, SLC12A3
28bartter syndrome type 310.1REN, SLC12A3
29bartter disease10.1SLC12A3, REN
30pseudohypoaldosteronism10.1REN, SLC12A3
31ovarian hyperstimulation syndrome10.1REN, ALB
32low renin hypertension10.0EDN1, REN
33hepatopulmonary syndrome10.0EDN1, ALB
34acute kidney failure10.0ALB, REN
35portal hypertension10.0EDN1, ALB
36metabolic acidosis10.0ALB, REN
37primary hyperoxaluria10.0REN, SLC12A3
38secondary hyperparathyroidism of renal origin10.0ALB, EPO
39hypertension, diastolic10.0REN, ACE
40hyperparathyroidism10.0ALB, EPO
41sickle cell disease10.0EDN1, EPO
42renal artery disease10.0ACE, ALB
43idiopathic edema10.0EDN1, ACE
44peripheral vascular disease10.0ACE, ALB
45polycystic kidney disease, autosomal dominant10.0ACE, REN
46focal segmental glomerulosclerosis10.0ALB, ACE
47hepatorenal syndrome10.0ALB, REN, EDN1
48cork-handlers' disease10.0ALB, ACE
49erythrocytosis10.0EPO, ACE
50liver cirrhosis10.0EDN1, REN, ALB

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Symptoms for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Renal Hypertension

Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Search CenterWatch for Renal Hypertension

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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34MalaCards
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MalaCards organs/tissues related to Renal Hypertension:

34
Kidney, Heart, Brain, Testes, Endothelial, Smooth muscle, Cortex, Cardiac myocytes, Medulla oblongata, Hypothalamus, Thymus, Placenta, Adrenal gland, Thyroid, Pancreas, Retina, Adrenal cortex

Animal Models for Renal Hypertension or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Renal Hypertension:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1EDN1, EPO, REN, ALB
2MP:00053677.8SLC12A3, ALB, ACE, REN, EDN1
3MP:00053857.5EDN1, EPO, REN, ACE, SLC12A3
4MP:00107687.5ALB, ACE, REN, EPO, EDN1
5MP:00053767.1EDN1, EPO, REN, ACE, ALB, SLC12A3

Publications for Renal Hypertension

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53PubMed
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Articles related to Renal Hypertension:

(show top 50)    (show all 500)
idTitleAuthorsYear
1
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
2
Neurogenic factors in renal hypertension. (12003710)
2002
3
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. (10666094)
2000
4
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. (10706380)
2000
5
Vasoactive intestinal contractor as a genesis of renal hypertension. (7723902)
1995
6
Mechanisms of renal hypertension and renal contribution to primary hypertension. (8116014)
1993
7
Characteristics of arterial myosin in experimental renal hypertension in the dog. (8491497)
1993
8
Sustained release verapamil in renal hypertension. (2966736)
1988
9
Sepsis and death after embolization of host kidneys in a resistant renal hypertension transplanted patient. (3050575)
1988
10
Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. (2974250)
1988
11
Changes of the intrinsic heart rate during the onset of renal hypertension. (3429876)
1987
12
Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: myosin, myosin ATPase and collagen. (2951526)
1987
13
Different cation transport inhibitor in benign and malignant experimental renal hypertension. (3794332)
1986
14
Experimental basis of angioinfarction for the treatment of renal hypertension. (2938325)
1986
15
Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat. (3024889)
1986
16
Cardiovascular and hormonal effects of clonidine in patients with essential hypertension and renal hypertension. (3913757)
1985
17
Effect of l-p-tyrosine on the development of renal hypertension in rats. (4048261)
1985
18
Post traumatic renal hypertension. (6383316)
1984
19
Contrasting effects of the renin-angiotensin system on renal function disclosed during converting enzyme inhibition in patients with renal hypertension. (6089319)
1984
20
Baroreceptor function during natural sleep in rats with mild and severe renal hypertension. (7182026)
1982
21
Renal venous renin activity in various forms of curable renal hypertension. (7018775)
1981
22
Transmembrane action potentials and the electrocardiogram in rats with renal hypertension. (6459847)
1981
23
Experimental renal hypertension in pregnant sheep. II. Response to a one-kidney model. (7032300)
1981
24
Renal hypertension secondary to ureteropelvis junction obstruction. Unusual presentation and new therapeutic modality. (7456201)
1981
25
Cardiomyopathy produced in rats with acute renal hypertension. (7354229)
1980
26
Effect of dietary salt on hemodynamics of established renal hypertension in the rabbit. Implications for the autoregulation theory of hypertension. (7007237)
1980
27
On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. (477821)
1979
28
Prostaglandins in renovascular and renal hypertension. (699590)
1978
29
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
30
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977
31
Dose response of SQ 20, 858 in chronic renal hypertension. (194265)
1977
32
The pathophysiology of renal hypertension. (271507)
1977
33
Renal kallikrein system, volemia, and renal hypertension. (875470)
1977
34
Unusual problems in renal hypertension. (1262150)
1976
35
Norepinephrine infusion in normal subjects and patients with essential or renal hypertension: effect on blood pressure, heart rate, and plasma catecholamine concentrations. (943425)
1976
36
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
37
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975
38
Role of angiotensin II in experimental renal hypertension in the rabbit. (1146999)
1975
39
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. (234677)
1975
40
Sympathetic influence on vascular smooth muscle contractility in renal hypertension in the rabbit. (1226729)
1975
41
Proceedings: Effect of chronic oral administration of propranolol on spontaneously and renal hypertension rats. (1160179)
1975
42
Salt appetite during the early phase of renal hypertension in rats. (1171438)
1975
43
Proceedings: Effects of removal of endocrine organs on spontaneous and renal hypertension in rats. (4546178)
1974
44
Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. (4275703)
1974
45
The effect on renal hypertension of subcutaneous isotransplantation of renal medulla from normal or hypertensive rats. Including studies on spontaneous variations in blood pressure in normal and hypertensive rats. (4589285)
1973
46
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance. (5084880)
1972
47
Modification of thyroid activity during development of experimental renal hypertension in rats. (5570560)
1971
48
Metabolism of renal cortex in ischemic renal hypertension. (5090359)
1971
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Effect of sodium diethyldithiocarbamate (DDC) on renal hypertension in rats. (5353264)
1969

Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for genes affiliated with Renal Hypertension

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 54QIAGEN, 56Reactome, 52PharmGKB
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Compounds for genes affiliated with Renal Hypertension

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Sources:
46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Renal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ornipressin469.8ALB, REN
2toki-shakuyaku-san469.8EDN1, REN
3darusentan46 3010.6EDN1, REN
4eprex469.5EPO, ALB
551-cr-edta469.5REN, ALB
6ibopamine469.5ACE, REN
7sampatrilat469.5REN, ACE
8remikiren46 1210.4REN, ACE
9perindoprilat469.4REN, ACE
10alacepril469.3ACE, REN
11midodrine46 1210.3ALB, EPO
12aliskiren46 1210.3ACE, REN
13thiazide469.2SLC12A3, REN, ACE
14lacidipine469.1REN, EDN1, ACE
15indapamide46 1210.1ALB, ACE, REN
16cilazapril46 1210.1REN, EDN1, ACE
17trandolapril46 1210.1REN, EDN1, ACE
18omapatrilat469.1EDN1, REN, ACE
19bucindolol46 5210.1ACE, REN
20celecoxib46 62 30 52 25 1214.1ALB, EPO, REN
21fosinopril46 1210.1REN, ALB, ACE
22quinapril46 52 1211.1EDN1, REN, ACE
23enalaprilat469.1ACE, EDN1, REN
24lisinopril46 52 25 1212.1REN, ACE, ALB
25ramipril46 1210.1REN, ACE, ALB
26chymostatin469.1ACE, REN, EDN1
27hydralazine46 52 1211.1ACE, REN, EDN1
28perindopril46 52 1211.1ALB, ACE, REN
29telmisartan46 30 1211.1REN, ACE, ALB
30atenolol46 52 30 25 1213.0ACE, REN, EDN1
31dihydropyridine469.0REN, EDN1, ACE
32diltiazem46 30 52 1212.0EDN1, REN, ACE
33candesartan46 52 30 1212.0ALB, ACE, REN
34amlodipine46 52 25 1212.0ALB, ACE, REN
35spironolactone46 62 30 52 1213.0ALB, ACE, REN
36carvedilol46 52 30 1212.0REN, ACE, EDN1
37nitroglycerin46 1210.0EDN1, REN, ACE
38ang ii469.0ACE, REN, EDN1
39kininogen469.0ALB, ACE, REN
40dihydralazine468.9REN, ACE
41hydrochlorothiazide46 30 52 25 1212.7ACE, REN, ALB, SLC12A3
42furosemide46 62 30 52 25 1213.7REN, ACE, ALB, SLC12A3
43valsartan46 62 30 1211.6EDN1, REN, ACE, ALB
44irbesartan46 30 52 1211.6ACE, REN, ALB, EDN1
45captopril46 62 52 30 1212.6EDN1, REN, ACE, ALB
46losartan46 52 30 1211.6EDN1, REN, ACE, ALB
47potassium46 25 1210.6ALB, REN, ACE, SLC12A3
48sodium46 259.2SLC12A3, ALB, REN, EDN1, ACE
49enalapril46 52 1210.0ALB, ACE, REN, EPO, EDN1
50creatinine467.9EDN1, EPO, REN, ACE, ALB

GO Terms for genes affiliated with Renal Hypertension

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17Gene Ontology
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Cellular components related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.5EPO, REN, ACE, ALB, EDN1
2extracellular spaceGO:0056157.2ALB, ACE, REN, EPO, EDN1

Biological processes related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:0020039.3ACE, REN
2response to testosteroneGO:0335749.2EPO, EDN1
3kidney developmentGO:0018229.2ACE, REN
4regulation of vasoconstrictionGO:0192299.1EDN1, ACE
5response to lipopolysaccharideGO:0324969.0REN, EPO, EDN1
6regulation of blood pressureGO:0082178.9ACE, REN

Molecular functions related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.3EPO, EDN1
2drug bindingGO:0081448.8ALB, ACE

Products for genes affiliated with Renal Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renal Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet