MCID: RNL015
MIFTS: 42

Renal Hypertension malady

Nephrological diseases category

Summaries for Renal Hypertension

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MalaCards based summary: Renal Hypertension, also known as hypertension renal, is related to kidney disease and gitelman syndrome. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF-1 signaling pathway and HIF-1-alpha transcription factor network. The compounds ornipressin and toki-shakuyaku-san have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are normal and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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Sources:
9Disease Ontology, 60UMLS, 43Novoseek, 38NCIt, 33MeSH, 55SNOMED-CT
See all sources

Renal Hypertension, Aliases & Descriptions:

Name: Renal Hypertension 9 60
 
Hypertension Renal 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


External Ids:

Disease Ontology9 DOID:1073
NCIt38 C3121
SNOMED-CT55 28119000, 194775007
MeSH33 D006977

Related Diseases for Renal Hypertension

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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 118)
idRelated DiseaseScoreTop Affiliating Genes
1kidney disease30.4REN, SLC12A3
2gitelman syndrome30.3REN, SLC12A3
3renovascular hypertension30.3ACE, REN
4malignant hypertension30.0REN, ACE
5renal tubular dysgenesis30.0REN, ACE
6uremia30.0ALB, EPO
7liver cirrhosis29.9EDN1, REN, ALB
8proteinuria29.6ALB, ACE, REN, EDN1
9hypoaldosteronism10.4REN
10fibromuscular dysplasia10.4REN
11congestive heart failure10.4REN
12malignant hypertensive renal disease10.4
13hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.4
14benign hypertensive renal disease10.3
15oligohydramnios10.3ACE
16anuria10.3ACE
17neuronitis10.3
18pseudohypoaldosteronism, type iie10.3REN, SLC12A3
19bartter syndrome, type 310.3REN, SLC12A3
20bartter disease10.3SLC12A3, REN
21pseudohypoaldosteronism10.2REN, SLC12A3
22cerebritis10.2
23ovarian hyperstimulation syndrome10.2REN, ALB
24hepatopulmonary syndrome10.2EDN1, ALB
25acute kidney failure10.2ALB, REN
26endotheliitis10.2
27portal hypertension10.2EDN1, ALB
28metabolic acidosis10.2ALB, REN
29secondary hyperparathyroidism of renal origin10.1ALB, EPO
30hyperparathyroidism10.1ALB, EPO
31hypertension, diastolic10.1REN, ACE
32sickle cell disease10.1EDN1, EPO
33insulin-like growth factor i10.1
34renal cell carcinoma10.1
35pulmonary hypertension10.1
36polycystic kidney disease10.1
37congenital mesoblastic nephroma10.1
38aneurysm10.1
39mesoblastic nephroma10.1
40nutritional deficiency disease10.1EPO, ALB
41renal artery disease10.1ACE, ALB
42hypertensive nephropathy10.1ACE, ALB
43idiopathic edema10.1EDN1, ACE
44peripheral vascular disease10.0ACE, ALB
45polycystic kidney disease, autosomal dominant10.0ACE, REN
46focal segmental glomerulosclerosis10.0ALB, ACE
47hepatorenal syndrome10.0ALB, REN, EDN1
48cork-handlers' disease10.0ALB, ACE
49iga glomerulonephritis10.0ALB, ACE
50nephritis10.0ACE, ALB

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Symptoms for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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MalaCards organs/tissues related to Renal Hypertension:

31
Kidney, Heart, Brain, Testes, Endothelial, Cortex, Smooth muscle, Thymus, Retina, Pancreas, Thyroid, Adrenal gland, Placenta, Hypothalamus, Medulla oblongata, Cardiac myocytes, Adrenal cortex

Animal Models for Renal Hypertension or affiliated genes

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MGI Mouse Phenotypes related to Renal Hypertension:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.1EDN1, EPO, REN, ALB
2MP:00053677.8SLC12A3, ALB, ACE, REN, EDN1
3MP:00053857.5EDN1, EPO, REN, ACE, SLC12A3
4MP:00107687.5ALB, ACE, REN, EPO, EDN1
5MP:00053767.1EDN1, EPO, REN, ACE, ALB, SLC12A3

Publications for Renal Hypertension

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Articles related to Renal Hypertension:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. (25097277)
2014
2
Prenatal diagnosis of congenital mesoblastic nephroma associated with renal hypertension in a premature child. (14678186)
2004
3
Neurogenic factors in renal hypertension. (12003710)
2002
4
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. (10666094)
2000
5
Effects of YM358, an angiotensin II type 1 (AT1) receptor antagonist, and enalapril on blood pressure and vasoconstriction in two renal hypertension models. (10706380)
2000
6
Vasoactive intestinal contractor as a genesis of renal hypertension. (7723902)
1995
7
Mechanisms of renal hypertension and renal contribution to primary hypertension. (8116014)
1993
8
Characteristics of arterial myosin in experimental renal hypertension in the dog. (8491497)
1993
9
Sustained release verapamil in renal hypertension. (2966736)
1988
10
Sepsis and death after embolization of host kidneys in a resistant renal hypertension transplanted patient. (3050575)
1988
11
Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. (2974250)
1988
12
Changes of the intrinsic heart rate during the onset of renal hypertension. (3429876)
1987
13
Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: myosin, myosin ATPase and collagen. (2951526)
1987
14
Different cation transport inhibitor in benign and malignant experimental renal hypertension. (3794332)
1986
15
Experimental basis of angioinfarction for the treatment of renal hypertension. (2938325)
1986
16
Pressor sensitivity to angiotensin I and angiotensin II during the development of experimental renal hypertension in the rat. (3024889)
1986
17
Cardiovascular and hormonal effects of clonidine in patients with essential hypertension and renal hypertension. (3913757)
1985
18
Effect of l-p-tyrosine on the development of renal hypertension in rats. (4048261)
1985
19
Post traumatic renal hypertension. (6383316)
1984
20
Contrasting effects of the renin-angiotensin system on renal function disclosed during converting enzyme inhibition in patients with renal hypertension. (6089319)
1984
21
Renal vein renin on acute stimulation in diagnosis of renal hypertension. (6367378)
1983
22
Baroreceptor function during natural sleep in rats with mild and severe renal hypertension. (7182026)
1982
23
Renal venous renin activity in various forms of curable renal hypertension. (7018775)
1981
24
Transmembrane action potentials and the electrocardiogram in rats with renal hypertension. (6459847)
1981
25
Experimental renal hypertension in pregnant sheep. II. Response to a one-kidney model. (7032300)
1981
26
Cardiomyopathy produced in rats with acute renal hypertension. (7354229)
1980
27
Effect of dietary salt on hemodynamics of established renal hypertension in the rabbit. Implications for the autoregulation theory of hypertension. (7007237)
1980
28
On the lipid granularity of renomedullary interstitial cells in benign and malignant courses of renal hypertension. (477821)
1979
29
Prostaglandins in renovascular and renal hypertension. (699590)
1978
30
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
31
Reversible renal hypertension secondary to renal arteriovenous fistula and renal cell carcinoma. (833981)
1977
32
Dose response of SQ 20, 858 in chronic renal hypertension. (194265)
1977
33
The pathophysiology of renal hypertension. (271507)
1977
34
Renal kallikrein system, volemia, and renal hypertension. (875470)
1977
35
Unusual problems in renal hypertension. (1262150)
1976
36
Norepinephrine infusion in normal subjects and patients with essential or renal hypertension: effect on blood pressure, heart rate, and plasma catecholamine concentrations. (943425)
1976
37
Pathogenesis of malignant hypertension: experimental evidence from the renal hypertensive rat. (1192618)
1975
38
Central serotonergic neurons and experimental neurogenic and renal hypertension in the rabbit. (1077778)
1975
39
Role of angiotensin II in experimental renal hypertension in the rabbit. (1146999)
1975
40
The renin axis and vasoconstriction volume analysis for understanding and treating renovascular and renal hypertension. (234677)
1975
41
Sympathetic influence on vascular smooth muscle contractility in renal hypertension in the rabbit. (1226729)
1975
42
Proceedings: Effect of chronic oral administration of propranolol on spontaneously and renal hypertension rats. (1160179)
1975
43
Salt appetite during the early phase of renal hypertension in rats. (1171438)
1975
44
Proceedings: Effects of removal of endocrine organs on spontaneous and renal hypertension in rats. (4546178)
1974
45
Rate and extent of adaptive cardiovascular changes in rats during experimental renal hypertension. (4275703)
1974
46
The effect on renal hypertension of subcutaneous isotransplantation of renal medulla from normal or hypertensive rats. Including studies on spontaneous variations in blood pressure in normal and hypertensive rats. (4589285)
1973
47
Hemodynamics of early experimental renal hypertension in dogs. Normal limb blood flow, elevated limb vascular resistance, and decreased venous compliance. (5084880)
1972
48
Modification of thyroid activity during development of experimental renal hypertension in rats. (5570560)
1971
49
The influence of uremia upon renal hypertension. (5438011)
1970
50
Effect of sodium diethyldithiocarbamate (DDC) on renal hypertension in rats. (5353264)
1969

Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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Search GEO for disease gene expression data for Renal Hypertension.

Pathways for genes affiliated with Renal Hypertension

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Compounds for genes affiliated with Renal Hypertension

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Compounds related to Renal Hypertension according to GeneCards Suite gene sharing:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1ornipressin439.8ALB, REN
2toki-shakuyaku-san439.8EDN1, REN
3darusentan43 2810.6EDN1, REN
4eprex439.5EPO, ALB
551-cr-edta439.5REN, ALB
6ibopamine439.5ACE, REN
7sampatrilat439.5REN, ACE
8remikiren43 1210.4REN, ACE
9perindoprilat439.4REN, ACE
10alacepril439.3ACE, REN
11midodrine43 1210.3ALB, EPO
12aliskiren43 1210.3ACE, REN
13thiazide439.2SLC12A3, REN, ACE
14lacidipine439.1REN, EDN1, ACE
15indapamide43 1210.1ALB, ACE, REN
16cilazapril43 1210.1REN, EDN1, ACE
17trandolapril43 1210.1REN, EDN1, ACE
18omapatrilat439.1EDN1, REN, ACE
19bucindolol43 4910.1ACE, REN
20celecoxib43 59 28 49 24 1214.1ALB, EPO, REN
21fosinopril43 1210.1REN, ALB, ACE
22quinapril43 49 1211.1EDN1, REN, ACE
23enalaprilat439.1ACE, EDN1, REN
24lisinopril43 49 24 1212.1REN, ACE, ALB
25ramipril43 1210.1REN, ACE, ALB
26chymostatin439.1ACE, REN, EDN1
27hydralazine43 49 1211.1ACE, REN, EDN1
28perindopril43 49 1211.1ALB, ACE, REN
29telmisartan43 28 1211.1REN, ACE, ALB
30atenolol43 49 28 24 1213.0ACE, REN, EDN1
31dihydropyridine439.0REN, EDN1, ACE
32diltiazem43 28 49 1212.0EDN1, REN, ACE
33candesartan43 49 28 1212.0ALB, ACE, REN
34amlodipine43 49 24 1212.0ALB, ACE, REN
35spironolactone43 59 28 49 1213.0ALB, ACE, REN
36carvedilol43 49 28 1212.0REN, ACE, EDN1
37nitroglycerin43 1210.0EDN1, REN, ACE
38ang ii439.0ACE, REN, EDN1
39kininogen439.0ALB, ACE, REN
40dihydralazine438.9REN, ACE
41hydrochlorothiazide43 28 49 24 1212.7ACE, REN, ALB, SLC12A3
42furosemide43 59 28 49 24 1213.7REN, ACE, ALB, SLC12A3
43valsartan43 59 28 1211.6EDN1, REN, ACE, ALB
44irbesartan43 28 49 1211.6ACE, REN, ALB, EDN1
45captopril43 59 49 28 1212.6EDN1, REN, ACE, ALB
46losartan43 49 28 1211.6EDN1, REN, ACE, ALB
47potassium43 24 1210.6ALB, REN, ACE, SLC12A3
48sodium43 249.2SLC12A3, ALB, REN, EDN1, ACE
49enalapril43 49 1210.0ALB, ACE, REN, EPO, EDN1
50creatinine437.9EDN1, EPO, REN, ACE, ALB

GO Terms for genes affiliated with Renal Hypertension

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Cellular components related to Renal Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.5EPO, REN, ACE, ALB, EDN1
2extracellular spaceGO:00056157.2ALB, ACE, REN, EPO, EDN1

Biological processes related to Renal Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1angiotensin maturationGO:00020039.3ACE, REN
2response to testosteroneGO:00335749.2EPO, EDN1
3kidney developmentGO:00018229.2ACE, REN
4regulation of vasoconstrictionGO:00192299.1EDN1, ACE
5response to lipopolysaccharideGO:00324969.0REN, EPO, EDN1
6regulation of blood pressureGO:00082178.9ACE, REN

Molecular functions related to Renal Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:00051799.3EPO, EDN1
2drug bindingGO:00081448.8ALB, ACE

Products for genes affiliated with Renal Hypertension

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Sources for Renal Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet