MCID: RNL015
MIFTS: 60

Renal Hypertension malady

Nephrological diseases category

Summaries for Renal Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renal Hypertension, also known as hypertensive disease, is related to hypertension and essential hypertension. An important gene associated with Renal Hypertension is SLC12A3 (solute carrier family 12 (sodium/chloride transporter), member 3), and among its related pathways are HIF1Alpha Pathway and Insulin Processing. The drugs diltiazem and felodipine and the compounds ornipressin and potassium chloride have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related mouse phenotypes are cardiovascular system and renal/urinary system.

Aliases & Classifications for Renal Hypertension

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8Disease Ontology, 60UMLS, 44Novoseek, 39NCIt, 34MeSH, 56SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal hypertension 8 60
hypertensive disease 60
hypertension renal 44


External Ids:

Disease Ontology8 DOID:1073
NCIt39 C3121
SNOMED-CT56 194775007, 28119000
MeSH34 D006977

Related Diseases for Renal Hypertension

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17GeneCards, 18GeneDecks
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Diseases related to Renal Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension31.8ALB, KNG1, ACE, EDN1, SLC12A3, REN
2essential hypertension30.8ALB, SLC12A3, REN, KNG1, ACE, EDN1
3malignant hypertension30.5ACE, REN
4renovascular hypertension30.4ACE, REN
5proteinuria30.0KNG1, ALB, EDN1, REN, ACE
6ischemia29.9KNG1, EDN1
7portal hypertension29.9ALB, EDN1
8glaucoma29.8EDN1
9pheochromocytoma29.8KNG1
10obesity29.8KNG1
11gitelman syndrome29.8REN, SLC12A3
12uremia29.8ALB, EPO
13arthritis29.8ALB, KNG1
14hypertensive nephropathy29.8ACE, ALB
15renal vascular disease29.8ALB, ACE
16vascular disease29.8EDN1, KNG1, ACE
17connective tissue disease29.7ALB
18thrombocytopenia29.7ALB, EPO
19malignant hypertensive renal disease10.3
20hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.3
21neuronitis10.2
22benign hypertensive renal disease10.2
23cerebritis10.2
24malignant essential hypertension10.0
25kidney hypertrophy10.0
26polycystic kidney disease10.0
27congenital mesoblastic nephroma10.0
28kidney disease10.0
29renal cell carcinoma10.0
30pulmonary fibrosis10.0EDN1
31proliferative diabetic retinopathy10.0EDN1
32cor pulmonale10.0EDN1
33hypoaldosteronism10.0REN
34fibromuscular dysplasia10.0REN
35neuropathy10.0ALB
36ulcerative colitis10.0ALB
37peritonitis10.0ALB
38cystic fibrosis10.0ALB
39vasculitis10.0ALB
40crohn's disease10.0ALB
41galactosemia10.0ALB
42allergic rhinitis10.0KNG1
43hepatitis c10.0ALB
44lupus nephritis10.0ALB
45intracranial hypertension10.0ALB
46cholestasis10.0ALB
47wilms tumor10.0REN
48polycythemia10.0EPO
49diarrhea10.0ALB
50leukemia10.0EPO

Graphical network of the top 20 diseases related to Renal Hypertension:



Diseases related to renal hypertension

Clinical Features for Renal Hypertension

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Drugs & Therapeutics for Renal Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renal Hypertension

Drug clinical trials:

Search ClinicalTrials for Renal Hypertension

Search NIH Clinical Center for Renal Hypertension

Search CenterWatch for Renal Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Renal Hypertension

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Anatomical Context for Renal Hypertension

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32MalaCards
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MalaCards organs/tissues related to Renal Hypertension:

32
Kidney, Heart, Brain, Testes, Endothelial, Smooth muscle, Lung, Cortex, Placenta, Adrenal gland, Adrenal cortex, Retina, Monocytes, Bone, Thymus, Cardiac myocytes, Hypothalamus, Cervix, Thyroid, Pancreas, Medulla oblongata

Animal Models for Renal Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053857.8ACE, SLC12A3, REN, EPO, EDN1
2MP:00053677.6EDN1, REN, SLC12A3, ACE, ALB
3MP:00053766.6ALB, ACE, SLC12A3, REN, EPO, KNG1

Publications for Renal Hypertension

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50PubMed
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Articles related to Renal Hypertension:

(show top 50)    (show all 1337)
idTitleAuthorsYear
1
Renal sympathetic denervation in resistant hypertension late after surgical repair for aortic coarctation. (23821399)
2013
2
Hyperprolactinemia as a rare cause of hypertension in chronic renal failure. (22462393)
2012
3
Trandolapril, but not verapamil nor their association, restores the physiological renal hemodynamic response to adrenergic activation in essential hypertension. (21575919)
2011
4
Renal dysfunction associated with intra-abdominal hypertension and the abdominal compartment syndrome. (21310818)
2011
5
Use of hypertonic continuous venovenous hemodiafiltration to control intracranial hypertension in an end-stage renal disease patient. (21152202)
2010
6
Effects of benidipine, a long-acting T-type calcium channel blocker, on home blood pressure and renal function in patients with essential hypertension: a retrospective, 'real-world' comparison with amlodipine. (19813777)
2009
7
Anemia and hypertension are risk factors for both renal prognosis and survival in patients with diabetes mellitus. (19452241)
2009
8
Treatment of hypertension in patients with diabetes mellitus : relevance of sympathovagal balance and renal function. (17593318)
2007
9
Pre-operative renal function and selective renal vein renin levels as markers of favourable outcome in renovascular hypertension. (18062531)
2007
10
Role of endothelial-derived nitric oxide in hypertension and renal disease. (17293684)
2007
11
Fibromuscular dysplasia in an accessory renal artery causing renovascular hypertension: a case report. (17672905)
2007
12
Renal autotransplantation for the treatment of complex renovascular hypertension. (17175289)
2006
13
AT(2) receptors mediate tonic renal medullary vasoconstriction in renovascular hypertension. (15678096)
2005
14
Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial. (15716710)
2005
15
Two cases of renovascular hypertension and ischemic renal dysfunction: reliable choice of examinations and treatments. (15894840)
2004
16
Method of experimental constriction of renal artery for modeling of renovascular hypertension in rats. (15514737)
2004
17
Malignant hypertension presenting as hemolysis, thrombocytopenia, and renal failure. (14674379)
2003
18
Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension. (11997278)
2002
19
Dyslipidemia and hypertension: twin killers in renal vascular disease. (11382708)
2001
20
Effects of a long-acting formulation of octreotide on renal function and renal sodium handling in cirrhotic patients with portal hypertension: a randomized, double-blind, controlled trial. (11526531)
2001
21
Role of angiotensin II and free radicals in blood pressure regulation in a rat model of renal hypertension. (11566905)
2001
22
Clinical usefulness of duplex ultrasonography for the assessment of renal arteriosclerosis in essential hypertensive patients. (11213024)
2001
23
Altered renal sodium handling and hypertension in men carrying the glucagon receptor gene (Gly40Ser) variant. (11692154)
2001
24
G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. (11244012)
2001
25
Renovascular hypertension treated by renal autotransplantation. (10932968)
2000
26
Human adrenomedullin gene delivery protects against cardiac hypertrophy, fibrosis, and renal damage in hypertensive dahl salt-sensitive rats. (10986555)
2000
27
Renal endothelin-1 is linked to changes in urinary salt and volume in essential hypertension. Salt Sensitivity Group of the Italian Society of Hypertension. (10928293)
2000
28
Serial magnetic resonance imaging of rat brain after induction of renal hypertension. (10548682)
1999
29
Adducin polymorphism affects renal proximal tubule reabsorption in hypertension. (10024330)
1999
30
Renal extraction of atrial natriuretic peptide in hypertensive patients with or without renal artery stenosis. (8641732)
1996
31
Renal vasoactive mediator generation in portal hypertensive and bile duct ligated rats. (8738735)
1996
32
Acute blockage of the renin system and differential renal vein renin determinations in the diagnosis of renovascular hypertension. (8727869)
1996
33
Renal and systemic effects of the renin inhibitor remikiren in patients with essential hypertension. (7564363)
1995
34
Renal effects of immersion in essential hypertension. Carvedilol Study Group. (8179847)
1994
35
Role of renin-angiotensin system in the impairment of baroreflex control of heart rate in renal hypertension. (1663968)
1991
36
Microvascular morphometry and perfusion in renal hypertension-induced cardiac hypertrophy. (2974250)
1988
37
Tachycardia during the onset of one-kidney, one-clip renal hypertension: role of the renin-angiotensin system and AV3V tissue. (3370491)
1988
38
Embolization of the kidney in secondary renal hypertension as an alternative to surgical nephrectomy. An experimental study. (3522473)
1986
39
Percutaneous transluminal renal artery angioplasty (PTRA) in hypertensive encephalopathy. (6223006)
1983
40
Embolization and angioplasty to relieve malignant hypertension and azotemia in a renal transplant patient. (6220804)
1982
41
Renal interstitial cell granularity in dogs with renal hypertension. (6265571)
1981
42
Captopril associated granulocytopenia in hypertension after renal transplantation. (6103273)
1980
43
Comparative effect of spironolactone and hydrochlorothiazide therapy in experimental renal hypertension of Rhesus monkeys. (98439)
1978
44
Renal kallikrein system, volemia, and renal hypertension. (875470)
1977
45
Mesenteric vasculature reactivity to noradrenaline during the development of renal hypertension in the rat. (851646)
1977
46
Proceedings: Effects of removal of endocrine organs on spontaneous and renal hypertension in rats. (4546178)
1974
47
Experience with hemodialysis and renal transplantation in patients with malignant hypertension. (4619667)
1974
48
Renal hypertension. (4593911)
1974
49
The effect of experimental renal hypertension on the response of the rabbit aorta to vitamin D. (4700699)
1973
50
A solid silver clip for induction of predictable levels of renal hypertension in the rat. (5556951)
1971

Genetic Variations for Renal Hypertension

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Expression for genes affiliated with Renal Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Hypertension

Search GEO for disease gene expression data for Renal Hypertension.

Pathways for genes affiliated with Renal Hypertension

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51QIAGEN, 53Reactome, 49PharmGKB, 37NCBI BioSystems Database
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Pathways related to Renal Hypertension according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0EDN1
2
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9.2ACE, REN
3
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8.7ACE, REN, KNG1

Compounds for genes affiliated with Renal Hypertension

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Sources:
44Novoseek, 11DrugBank, 2BitterDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 24HMDB
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Compounds related to Renal Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1ornipressin449.5REN, ALB
2potassium chloride44 1110.4EDN1, KNG1, REN
3papaverine44 2 1111.2EDN1, KNG1, EPO
4thiazide449.2REN, ACE, SLC12A3
5moexiprilat449.1KNG1, ACE
6perindoprilat449.1KNG1, REN, ACE
7cilazapril44 1110.1KNG1, ACE, EDN1
8chymostatin449.1ACE, EDN1, REN
9indapamide44 1110.1REN, ALB, ACE
10saralasin449.1ACE, REN, KNG1
11eprosartan44 28 1111.1REN, KNG1, ACE
12fosinopril44 1110.1REN, ACE, ALB
13isosorbide dinitrate44 49 1111.0ACE, KNG1, EDN1
14imidaprilat449.0KNG1, ACE
15polysulfone449.0ALB, EPO, KNG1
16dihydropyridine449.0EDN1, ACE, REN
17telmisartan44 28 1111.0ALB, ACE, REN
18irbesartan44 28 49 1112.0ALB, ACE, REN
19thiorphan44 28 1111.0KNG1, EDN1, ACE
20carvedilol44 49 28 1111.9REN, ACE, EDN1
21spironolactone49 44 59 28 1112.9REN, ACE, ALB
22an 69448.9KNG1, EPO, ACE
23amlodipine44 49 11 2411.9ALB, ACE, REN
24enalaprilate448.8KNG1, ACE
25hydrochlorothiazide44 49 28 11 2412.8ACE, ALB, REN, SLC12A3
26furosemide44 49 59 28 11 2413.7REN, ACE, ALB, SLC12A3
27phosphoramidon44 119.7EDN1, ACE, KNG1
28lacidipine448.7EDN1, KNG1, REN, ACE
29omapatrilat448.7EDN1, KNG1, REN, ACE
30trandolapril44 119.7EDN1, KNG1, REN, ACE
31quinapril44 119.7EDN1, KNG1, REN, ACE
32enalaprilat448.7KNG1, EDN1, REN, ACE
33valsartan44 59 28 1111.7ACE, ALB, REN, EDN1
34diltiazem44 28 1110.7EDN1, KNG1, REN, ACE
35nitroglycerin44 119.7ACE, EDN1, REN, KNG1
36ang ii448.7REN, KNG1, ACE, EDN1
37lisinopril44 11 2410.6KNG1, ACE, REN, ALB
38ramipril44 119.6REN, ALB, ACE, KNG1
39perindopril44 49 1110.6REN, KNG1, ALB, ACE
40candesartan44 28 1110.6KNG1, REN, ACE, ALB
41verapamil44 49 28 11 2412.6EDN1, KNG1, REN, ACE
42kininogen448.6ALB, KNG1, REN, ACE
43nifedipine44 49 28 1111.6ACE, REN, EDN1, KNG1
44prostacyclin448.5REN, ACE, EDN1, KNG1
45captopril44 28 49 59 1112.2ALB, REN, KNG1, EDN1, ACE
46potassium44 11 2410.2ACE, KNG1, ALB, SLC12A3, REN
47losartan44 49 28 1111.2EDN1, REN, KNG1, ACE, ALB
48creatinine447.9ALB, EDN1, ACE, EPO, REN
49sodium44 248.8ACE, SLC12A3, REN, KNG1, ALB, EDN1
50enalapril44 49 119.6ACE, ALB, EPO, KNG1, EDN1, REN

GO Terms for genes affiliated with Renal Hypertension

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16Gene Ontology
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Cellular components related to Renal Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.4ALB, KNG1
2extracellular spaceGO:0056157.0ACE, EDN1, KNG1, EPO, REN, ALB
3extracellular regionGO:0055766.8ALB, EDN1, KNG1, EPO, REN, ACE

Biological processes related to Renal Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of urine volumeGO:0358109.6KNG1, EDN1
2negative regulation of blood coagulationGO:0301959.5EDN1, KNG1
3positive regulation of renal sodium excretionGO:0358159.4KNG1, EDN1
4response to testosterone stimulusGO:0335749.4EPO, EDN1
5angiotensin maturationGO:0020039.4ACE, REN
6response to lipopolysaccharideGO:0324969.1REN, EPO, EDN1
7regulation of vasoconstrictionGO:0192298.9ACE, EDN1

Products for genes affiliated with Renal Hypertension

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Sources for Renal Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet