MCID: RNL017
MIFTS: 47

Renal Oncocytoma malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Cancer diseases

Aliases & Classifications for Renal Oncocytoma

About this section

Aliases & Descriptions for Renal Oncocytoma:

Name: Renal Oncocytoma 35 11 48 13
Oncocytoma, Renal 39 68
Renal Epithelial Oncocytic Tumor 11
 
Oncocytoma of Kidney 11
Oncocytoma Kidney 48
Oncocytoma Renal 48

Classifications:



External Ids:

Disease Ontology11 DOID:6245
MeSH39 C537750
SNOMED-CT62 254922006
NCIt45 C4526

Summaries for Renal Oncocytoma

About this section
NIH Rare Diseases:48 Renal oncocytoma is a benign (noncancerous) growth of the kidney. they generally do not cause any signs or symptoms and are often discovered incidentally (by chance) while a person is undergoing diagnostic imaging for other conditions. some people with renal oncocytoma will have abdominal or flank pain; blood in the urine; and/or an abdominal mass. although these tumors can occur in people of all ages, they most commonly develop in men who are over age 50. the exact underlying cause of most isolated (single tumor affecting one kidney) renal oncocytomas is unknown; however, multiple and bilateral (affecting both kidneys) renal oncocytomas sometimes occur in people with certain genetic syndromes such as tuberous sclerosis complex and birt-hogg-dube syndrome. although many benign tumors do not require treatment unless they are causing unpleasant symptoms, it can be difficult to confidently differentiate a renal oncocytoma from renal cell carcinoma. most affected people are, therefore, treated with surgery which allows for confirmation of the diagnosis. last updated: 3/29/2016

MalaCards based summary: Renal Oncocytoma, also known as oncocytoma, renal, is related to familial renal oncocytoma and birt-hogg-dube syndrome. An important gene associated with Renal Oncocytoma is CLDN8 (Claudin 8), and among its related pathways are B Cell Development Pathways and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include kidney, t cells and brain, and related mouse phenotypes are Decreased Salmonella enterica Typhimurium binding and Decreased Salmonella enterica Typhimurium ruffling.

Wikipedia:71 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell. more...

Related Diseases for Renal Oncocytoma

About this section

Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1familial renal oncocytoma12.2
2birt-hogg-dube syndrome10.9
3renal cell carcinoma10.5
4chromophobe renal cell carcinoma10.4
5liver angiosarcoma10.2KIT, MME
6uterine hypoplasia10.2KIT, MME
7paranasal sinus cancer10.2KIT, MME
8sphenoid sinus squamous cell carcinoma10.2KIT, MME
9rectal neoplasm10.2KIT, MME
10sebaceous adenoma10.1KIT, MME
11laryngeal neuroendocrine tumor10.1KIT, MME
12factitious disorder10.1KIT, MME
13cranial nerve disease10.1KIT, MME
14van regemorter pierquin vamos syndrome10.1KIT, MME
15pilar sheath acanthoma10.1KIT, MME
16arthus reaction10.0KIT, MME
17gallbladder cancer9.9CDH16, FLCN, KIT, MME
18lipoadenoma9.9CDH16, FLCN, KIT, MME
19lymphoma9.9
20adenoma9.9
21clear cell renal cell carcinoma9.9
22aneurysm9.9
23pheochromocytoma9.8
24tuberous sclerosis9.8
25prostatitis9.8
26renal adenoma9.8
27perinephritis9.8
28angiomyolipoma9.8
29eosinophilic variant of chromophobe renal cell carcinoma9.8
30thyroid carcinoma, papillary, with papillary renal neoplasia9.8CDH16, FLCN, KIT, MME, MST1R
31hepatocellular carcinoma9.6
32osteoporosis9.6
33b-cell lymphomas9.6
34diffuse large b-cell lymphoma9.6
35glomerulonephritis9.6
36renal fibrosis9.6
37endocarditis9.6
38nephrotic syndrome9.6
39leiomyoma9.6
40bladder leiomyoma9.6
41melanoma9.6
42colon adenocarcinoma9.6
43adenocarcinoma9.6
44papillary carcinoma9.6
45chromophobe adenoma9.6
46renal clear cell carcinoma9.6
47renal pelvis carcinoma9.6
48hemangioblastoma9.6
49conjunctivitis9.6
50bullous pemphigoid9.6

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to renal oncocytoma

Symptoms & Phenotypes for Renal Oncocytoma

About this section

GenomeRNAi Phenotypes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00133-A-310.2EGLN2, MAX
2GR00133-A-59.8EGLN2, FLCN, MAX

MGI Mouse Phenotypes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.4CAV1, EGLN2, KIT, MME, MST1R
2MP:00053878.2CAV1, EGLN2, EPCAM, FLCN, KIT, MME
3MP:00053768.0CAV1, CLDN8, EGLN2, EPCAM, FLCN, KIT

Drugs & Therapeutics for Renal Oncocytoma

About this section

Drugs for Renal Oncocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Technetium Tc 99m Sestamibi38
2Radiopharmaceuticals514

Interventional clinical trials:

idNameStatusNCT IDPhase
1Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney CancerRecruitingNCT01767636Phase 2
2Genetic Analysis of Inherited Urologic Malignant Disorders: Collection of SamplesCompletedNCT00001814
3Study of 99mTc-Sestamibi SPECT/CT Imaging for the Preoperative Diagnosis of Renal OncocytomaRecruitingNCT02160925
4Evaluation of Diagnostic Value of Molecular Markers in Renal CancerTerminatedNCT00491621

Search NIH Clinical Center for Renal Oncocytoma


Cochrane evidence based reviews: oncocytoma, renal

Genetic Tests for Renal Oncocytoma

About this section

Anatomical Context for Renal Oncocytoma

About this section

MalaCards organs/tissues related to Renal Oncocytoma:

36
Kidney, T cells, Brain, Prostate, Liver, Breast, Thyroid

Publications for Renal Oncocytoma

About this section

Articles related to Renal Oncocytoma:

(show top 50)    (show all 356)
idTitleAuthorsYear
1
Active surveillance is suitable for intermediate term follow-up of renal oncocytoma diagnosed by percutaneous core biopsy. (27457972)
2016
2
Renal oncocytoma: A report of two cases and review of the literature. (27347140)
2016
3
Voxel-based whole-lesion enhancement parameters: a study of its clinical value in differentiating clear cell renal cell carcinoma from renal oncocytoma. (27595574)
2016
4
A systematic review and meta-analysis of immunohistochemical biomarkers that differentiate chromophobe renal cell carcinoma from renal oncocytoma. (26951082)
2016
5
Renal Oncocytoma With Perinephric Fat Invasion. (27170678)
2016
6
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. (26670126)
2016
7
Bladder leiomyoma in male patient presenting with renal oncocytoma: Are the two conditions related? (27453673)
2016
8
Renal Oncocytoma with Vascular Invasion: A Series of 22 Cases. (27498062)
2016
9
Renal oncocytoma, small cell variant, with pseudorosettes, showing cyclin D1 expression and tubulovesicular cristae of mitochondria. (27076064)
2016
10
Comparative study of CT appearances in renal oncocytoma and chromophobe renal cell carcinoma. (25972369)
2015
11
DOG1, cyclin D1, CK7, CD117 and vimentin are useful immunohistochemical markers in distinguishing chromophobe renal cell carcinoma from clear cell renal cell carcinoma and renal oncocytoma. (25596994)
2015
12
Dilemmas in diagnosis and natural history of renal oncocytoma and implications for management. (26664505)
2015
13
Supremacy of modern morphometry in typing renal oncocytoma and malignant look-alikes. (25929744)
2015
14
Differentiation of renal oncocytoma and renal clear cell carcinoma using relative CT enhancement ratio. (25591558)
2015
15
The Genomic Landscape of Renal Oncocytoma Identifies a Metabolic Barrier to Tumorigenesis. (26655904)
2015
16
The clinicopathological, ultrastructural, genetic features and diagnosis of small cell variant renal oncocytoma. (25935740)
2015
17
HNF1I^ and S100A1 are useful biomarkers for distinguishing renal oncocytoma and chromophobe renal cell carcinoma in FNA and core needle biopsies. (25739652)
2015
18
Mitochondrial DNA mutations distinguish bilateral multifocal renal oncocytomas from familial Birt-Hogg-Dube tumors. (26428318)
2015
19
Cystic Renal Oncocytoma and Tubulocystic Renal Cell Carcinoma: Morphologic and Immunohistochemical Comparative Study. (26180933)
2015
20
Renal oncocytoma with invasive histopathologic features -a88 case report. (24739051)
2014
21
TGF-I^1 expression in chromophobe renal cell carcinoma and renal oncocytoma. (24704995)
2014
22
C-kit overexpression is not associated with KIT gene mutations in chromophobe renal cell carcinoma or renal oncocytoma. (24875296)
2014
23
Diagnostic accuracy of segmental enhancement inversion for diagnosis of renal oncocytoma at biphasic contrast enhanced CT: systematic review. (24663821)
2014
24
Diagnostic accuracy of segmental enhancement inversion for the diagnosis of renal oncocytoma using biphasic computed tomography (CT) and multiphase contrast-enhanced magnetic resonance imaging (MRI). (25027841)
2014
25
Ultrasonographic features of renal oncocytoma with histopathologic correlation. (24449166)
2014
26
An interesting case of F-18 fluorodeoxyglucose positron emission tomography avid renal oncocytoma. (24735168)
2014
27
Papillary renal cell carcinoma within a renal oncocytoma: Case report of very rare coexistence. (25553171)
2014
28
Renal oncocytoma: A diagnostic dilemma on cytology. (25190989)
2014
29
Cannabinoid CB1 receptor is expressed in chromophobe renal cell carcinoma and renal oncocytoma. (23318578)
2013
30
BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. (23242606)
2013
31
LMP2, a novel immunohistochemical marker to distinguish renal oncocytoma from the eosinophilic variant of chromophobe renal cell carcinoma. (22705098)
2013
32
The Management Of A Concomitant Renal Oncocytoma, Giant Coronary And Bilateral Common Iliac Artery Aneurysms. (24200531)
2013
33
Primary penile melanoma with an incidental renal oncocytoma. (24031073)
2013
34
Renal oncocytoma: contrast-enhanced sonographic features. (23443184)
2013
35
Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. (23765540)
2013
36
Giant renal oncocytoma. (23401933)
2013
37
Simultaneous renal oncocytoma and lymphoma: interest of lymphadenectomy. (23984175)
2013
38
Small cell variant of renal oncocytoma with liver metastases: a case report. (23775024)
2013
39
Giant renal oncocytoma. (23692817)
2013
40
Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. (23617489)
2013
41
Tumour-to-tumour metastases: prostate carcinoma metastasising to a renal oncocytoma. (23307454)
2013
42
Bilateral multifocal renal oncocytoma in pregnancy. (23372918)
2012
43
Renal oncocytoma growth rates before intervention. (22520366)
2012
44
Clinically undiagnosed prostate carcinoma metastatic to renal oncocytoma. (22754705)
2012
45
Utility of immunohistochemical analysis of KAI1, epithelial-specific antigen, and epithelial-related antigen for distinction of chromophobe renal cell carcinoma, an eosinophilic variant from renal oncocytoma. (22718295)
2012
46
Renal oncocytoma--are there sufficient grounds to consider surveillance following prenephrectomy histologic diagnosis. (20171908)
2012
47
Microscopic and nuclear morphometric findings of chromophobe renal cell carcinoma, renal oncocytoma, and tumor with overlapping histology. (22495123)
2012
48
Renal oncocytoma: experience of Clinical Urology A, Urology Department, CHU Ibn Sina, Rabat, Morocco and literature review. (23077705)
2012
49
A new translocation between chromosomes 6 and 9 helps to establish diagnosis of renal oncocytoma. (20952287)
2011
50
Case report of a symptomatic giant renal oncocytoma. (22096690)
2011

Variations for Renal Oncocytoma

About this section

Cosmic variations for Renal Oncocytoma:

8 (show all 28)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1COSM28419MDH1kidney,NS,carcinoma,oncocyticc.894G>Cp.K298N7
2COSM25647SMC6kidney,NS,carcinoma,oncocyticc.2911-1G>Cp.?7
3COSM26012UBR4kidney,NS,carcinoma,oncocyticc.4564G>Ap.A1522T7
4COSM130403SF3B1kidney,NS,carcinoma,oncocyticc.3122G>Ap.R1041H7
5COSM25680VHLkidney,NS,carcinoma,oncocyticc.563T>Gp.L188R7
6COSM26015ALDH7A1kidney,NS,carcinoma,oncocyticc.1486A>Gp.I496V7
7COSM27600FOXA2kidney,NS,carcinoma,oncocyticc.72C>Tp.G24G7
8COSM26614RABGAP1kidney,NS,carcinoma,renal cellc.1533T>Ap.H511Q6
9COSM30531COPS4kidney,NS,carcinoma,renal cellc.385G>Cp.G129R6
10COSM30471ARHGAP20kidney,NS,carcinoma,renal cellc.1355A>Gp.D452G6
11COSM30474TRIOkidney,NS,carcinoma,renal cellc.9008A>Gp.N3003S6
12COSM25654CDC5Lkidney,NS,carcinoma,renal cellc.1196G>Ap.R399Q6
13COSM25676VHLkidney,NS,carcinoma,renal cellc.485G>Tp.C162F6
14COSM28415DOCK1kidney,NS,carcinoma,renal cellc.1306G>Tp.D436Y6
15COSM30502ITPR3kidney,NS,carcinoma,renal cellc.4574G>Tp.C1525F6
16COSM27618KMT2Akidney,NS,carcinoma,renal cellc.5711C>Tp.A1904V6
17COSM30530PTPN22kidney,NS,carcinoma,renal cellc.209G>Cp.R70P6
18COSM26594RNF144Akidney,NS,carcinoma,renal cellc.410C>Tp.A137V6
19COSM27269UMPSkidney,NS,carcinoma,renal cellc.528G>Ap.L176L6
20COSM26987RGS7kidney,NS,carcinoma,renal cellc.169T>Cp.F57L6
21COSM17957VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.292T>Gp.Y98D5
22COSM17875VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.234T>Gp.N78K5
23COSM14305VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.266T>Ap.L89H5
24COSM52899PBRM1kidney,NS,carcinoma,renal cell carcinoma unclassifiedc.3805A>Tp.K1269*5
25COSM17983VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.500G>Ap.R167Q5
26COSM14312VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.353T>Cp.L118P5
27COSM14425VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.341-2A>Tp.?5
28COSM14382VHLkidney,NS,carcinoma,renal cell carcinoma unclassifiedc.245G>Cp.R82P5

Expression for genes affiliated with Renal Oncocytoma

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Renal Oncocytoma patients vs. healthy controls: 35 (show all 310)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1ACSM2Aacyl-CoA synthetase medium-chain family member 2AKidney-11.650.000
2ALDOBaldolase B, fructose-bisphosphateKidney-9.160.000
3NAT8N-acetyltransferase 8 (GCN5-related, putative)Kidney-9.120.000
4GLYATglycine-N-acyltransferaseKidney-8.920.000
5CTXN3cortexin 3Kidney-8.720.000
6ALDH8A1aldehyde dehydrogenase 8 family, member A1Kidney-8.580.000
7SLC12A1solute carrier family 12 (sodium/potassium/chloride transporter), member 1Kidney-8.510.000
8HPD4-hydroxyphenylpyruvate dioxygenaseKidney-8.480.000
9FABP1fatty acid binding protein 1, liverKidney-8.410.000
10GSTA1glutathione S-transferase alpha 1Kidney-8.320.000
11CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)Kidney+8.250.000
12CXCL14chemokine (C-X-C motif) ligand 14Kidney-8.130.000
13PLGplasminogenKidney-8.110.000
14MUC15mucin 15, cell surface associatedKidney-8.040.000
15ACMSDaminocarboxymuconate semialdehyde decarboxylaseKidney-7.880.000
16CALB1calbindin 1, 28kDaKidney-7.860.000
17RNF128ring finger protein 128, E3 ubiquitin protein ligaseKidney-7.830.000
18FMO1flavin containing monooxygenase 1Kidney-7.790.000
19UGT2B28UDP glucuronosyltransferase 2 family, polypeptide B28Kidney-7.750.000
20PAHphenylalanine hydroxylaseKidney-7.750.000
21KCNJ1potassium channel, inwardly rectifying subfamily J, member 1Kidney-7.710.000
22G6PCglucose-6-phosphatase, catalytic subunitKidney-7.610.000
23SCNN1Gsodium channel, non voltage gated 1 gamma subunitKidney-7.610.000
24AGXT2alanine--glyoxylate aminotransferase 2Kidney-7.600.000
25AQP6aquaporin 6, kidney specificKidney+7.570.000
26SLC16A9solute carrier family 16, member 9Kidney-7.570.000
27ALBalbuminKidney-7.540.000
28PDZK1IP1PDZK1 interacting protein 1Kidney-7.520.000
29MFSD4major facilitator superfamily domain containing 4Kidney-7.440.000
30MIOXmyo-inositol oxygenaseKidney-7.390.000
31ENPP6ectonucleotide pyrophosphatase/phosphodiesterase 6Kidney-7.330.000
32SLC7A13solute carrier family 7 (anionic amino acid transporter), member 13Kidney-7.290.000
33TMEM37transmembrane protein 37Kidney-7.260.000
34UGT3A1UDP glycosyltransferase 3 family, polypeptide A1Kidney-7.210.000
35LOC100505650uncharacterized LOC100505650Kidney-7.190.000
36ANPEPalanyl (membrane) aminopeptidaseKidney-7.170.000
37FAM151Afamily with sequence similarity 151, member AKidney-7.150.000
38C1Scomplement component 1, s subcomponentKidney-7.010.000
39CLRN3clarin 3Kidney-6.960.000
40EHFets homologous factorKidney-6.860.000
41SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3Kidney-6.860.000
42MGAMmaltase-glucoamylaseKidney-6.850.000
43TMEM255Atransmembrane protein 255AKidney+6.840.000
44TMEM45Btransmembrane protein 45BKidney-6.800.000
45CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 11Kidney-6.780.000
46BHMTbetaine--homocysteine S-methyltransferaseKidney-6.770.000
47NPHS2nephrosis 2, idiopathic, steroid-resistant (podocin)Kidney-6.770.000
48IRX2iroquois homeobox 2Kidney-6.750.000
49GLYATL1glycine-N-acyltransferase-like 1Kidney-6.730.000
50MT1Fmetallothionein 1FKidney-6.700.000
51LRP2low density lipoprotein receptor-related protein 2Kidney-6.680.000
52SLC22A2solute carrier family 22 (organic cation transporter), member 2Kidney-6.670.000
53BBOX1butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1Kidney-6.670.000
54GATA3GATA binding protein 3Kidney-6.650.001
55GATMglycine amidinotransferase (L-arginine:glycine amidinotransferase)Kidney-6.630.000
56DIO1deiodinase, iodothyronine, type IKidney-6.630.001
57HS6ST2heparan sulfate 6-O-sulfotransferase 2Kidney-6.600.000
58GCgroup-specific component (vitamin D binding protein)Kidney-6.590.000
59ASS1argininosuccinate synthase 1Kidney-6.570.000
60LRRC19leucine rich repeat containing 19Kidney-6.560.000
61KCNJ10potassium channel, inwardly rectifying subfamily J, member 10Kidney-6.530.000
62FXYD4FXYD domain containing ion transport regulator 4Kidney-6.470.000
63HHATLhedgehog acyltransferase-likeKidney+6.410.000
64UMODuromodulinKidney-6.350.000
65HAO2hydroxyacid oxidase 2 (long chain)Kidney-6.350.000
66MAOBmonoamine oxidase BKidney-6.340.000
67LGALS2lectin, galactoside-binding, soluble, 2Kidney-6.310.000
68RBP4retinol binding protein 4, plasmaKidney-6.280.001
69CLDN10claudin 10Kidney-6.250.000
70TSPAN8tetraspanin 8Kidney-6.250.000
71KCNJ16potassium channel, inwardly rectifying subfamily J, member 16Kidney-6.240.000
72SLC2A2solute carrier family 2 (facilitated glucose transporter), member 2Kidney-6.220.000
73SLCO4C1solute carrier organic anion transporter family, member 4C1Kidney-6.210.001
74SLC13A1solute carrier family 13 (sodium/sulfate symporter), member 1Kidney-6.190.001
75UPB1ureidopropionase, betaKidney-6.180.000
76MGST1microsomal glutathione S-transferase 1Kidney-6.170.000
77ACPPacid phosphatase, prostateKidney-6.160.000
78KNG1kininogen 1Kidney-6.140.000
79PTGDSprostaglandin D2 synthase 21kDa (brain)Kidney-6.070.000
80CAPN3calpain 3Kidney-6.000.000
81MMEmembrane metallo-endopeptidaseKidney-6.000.000
82KRT19keratin 19, type IKidney-6.000.001
83FLRT3fibronectin leucine rich transmembrane protein 3Kidney-5.990.000
84ABCB1ATP-binding cassette, sub-family B (MDR/TAP), member 1Kidney-5.980.002
85ADH6alcohol dehydrogenase 6 (class V)Kidney-5.970.000
86FREM2FRAS1 related extracellular matrix protein 2Kidney-5.960.000
87SERPINA5serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5Kidney-5.940.000
88SCGB1D2secretoglobin, family 1D, member 2Kidney-5.910.000
89AK4adenylate kinase 4Kidney-5.910.000
90NOX4NADPH oxidase 4Kidney-5.900.001
91MGPmatrix Gla proteinKidney-5.890.000
92SLC47A1solute carrier family 47 (multidrug and toxin extrusion), member 1Kidney-5.870.000
93TYRP1tyrosinase-related protein 1Kidney-5.860.000
94ACE2angiotensin I converting enzyme 2Kidney-5.850.002
95PRSS8protease, serine, 8Kidney-5.830.000
96GALNT3polypeptide N-acetylgalactosaminyltransferase 3Kidney-5.830.000
97SIM2single-minded family bHLH transcription factor 2Kidney-5.790.000
98AMNamnion associated transmembrane proteinKidney-5.790.000
99CYP4A22cytochrome P450, family 4, subfamily A, polypeptide 22Kidney-5.770.000
100SFTPBsurfactant protein BKidney+5.770.000
101GPC5glypican 5Kidney-5.750.000
102C7complement component 7Kidney-5.730.000
103TCF21transcription factor 21Kidney-5.730.000
104LUMlumicanKidney-5.720.027
105WWC1WW and C2 domain containing 1Kidney-5.710.000
106CDHR5cadherin-related family member 5Kidney-5.710.000
107PTPRDprotein tyrosine phosphatase, receptor type, DKidney-5.710.000
108BAALCbrain and acute leukemia, cytoplasmicKidney+5.690.000
109KCNJ3potassium channel, inwardly rectifying subfamily J, member 3Kidney-5.660.000
110SLC22A8solute carrier family 22 (organic anion transporter), member 8Kidney-5.660.000
111ADH1Balcohol dehydrogenase 1B (class I), beta polypeptideKidney-5.650.011
112DCNdecorinKidney-5.640.009
113FGFR3fibroblast growth factor receptor 3Kidney-5.640.008
114SLC2A5solute carrier family 2 (facilitated glucose/fructose transporter), member 5Kidney-5.640.000
115FAM150Bfamily with sequence similarity 150, member BKidney-5.630.005
116WT1Wilms tumor 1Kidney-5.630.001
117ESRRBestrogen-related receptor betaKidney-5.620.000
118PCDH7protocadherin 7Kidney-5.620.000
119AQP2aquaporin 2 (collecting duct)Kidney-5.620.001
120DPEP1dipeptidase 1 (renal)Kidney-5.600.000
121APOHapolipoprotein H (beta-2-glycoprotein I)Kidney-5.570.000
122ANO4anoctamin 4Kidney+5.560.000
123STK32Bserine/threonine kinase 32BKidney-5.550.000
124UGT2A3UDP glucuronosyltransferase 2 family, polypeptide A3Kidney-5.540.000
125LIMS3LIM and senescent cell antigen-like domains 3Kidney+5.530.000
126WNK4WNK lysine deficient protein kinase 4Kidney-5.530.000
127CXCL12chemokine (C-X-C motif) ligand 12Kidney-5.520.000
128RAB11FIP3RAB11 family interacting protein 3 (class II)Kidney-5.520.001
129DDCdopa decarboxylase (aromatic L-amino acid decarboxylase)Kidney-5.500.000
130SLITRK4SLIT and NTRK-like family, member 4Kidney-5.500.001
131CLIC5chloride intracellular channel 5Kidney-5.490.000
132PAPPApregnancy-associated plasma protein A, pappalysin 1Kidney-5.490.000
133SFRP1secreted frizzled-related protein 1Kidney-5.480.000
134GPSM2G-protein signaling modulator 2Kidney+5.480.000
135SLC22A6solute carrier family 22 (organic anion transporter), member 6Kidney-5.470.000
136PROM2prominin 2Kidney-5.460.000
137GBA3glucosidase, beta, acid 3 (gene/pseudogene)Kidney-5.460.000
138XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-boundKidney-5.450.000
139CAPN6calpain 6Kidney-5.450.000
140SLC6A13solute carrier family 6 (neurotransmitter transporter), member 13Kidney-5.440.000
141GALNT14polypeptide N-acetylgalactosaminyltransferase 14Kidney-5.430.000
142TMEM106Atransmembrane protein 106AKidney-5.420.002
143SLC17A3solute carrier family 17 (organic anion transporter), member 3Kidney-5.410.001
144NOS1nitric oxide synthase 1 (neuronal)Kidney-5.410.001
145SHMT1serine hydroxymethyltransferase 1 (soluble)Kidney-5.410.000
146SLC23A1solute carrier family 23 (ascorbic acid transporter), member 1Kidney-5.400.000
147MT1Mmetallothionein 1MKidney-5.400.000
148FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)Kidney-5.400.000
149SLC4A4solute carrier family 4 (sodium bicarbonate cotransporter), member 4Kidney-5.390.000
150HOGA14-hydroxy-2-oxoglutarate aldolase 1Kidney-5.390.003
151MAL2mal, T-cell differentiation protein 2 (gene/pseudogene)Kidney-5.390.000
152BHMT2betaine--homocysteine S-methyltransferase 2Kidney-5.390.001
153SLC5A12solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12Kidney-5.380.000
154AP1M2adaptor-related protein complex 1, mu 2 subunitKidney-5.380.000
155RALYLRALY RNA binding protein-likeKidney-5.370.000
156GLDCglycine dehydrogenase (decarboxylating)Kidney-5.370.000
157TMEM176Atransmembrane protein 176AKidney-5.360.000
158FOXC1forkhead box C1Kidney-5.350.001
159SLC6A19solute carrier family 6 (neutral amino acid transporter), member 19Kidney-5.350.000
160UPP2uridine phosphorylase 2Kidney-5.350.000
161TMEM176Btransmembrane protein 176BKidney-5.340.000
162KCNG1potassium channel, voltage gated modifier subfamily G, member 1Kidney+5.330.000
163CLDN16claudin 16Kidney-5.330.000
164HRGhistidine-rich glycoproteinKidney-5.310.000
165NTRK2neurotrophic tyrosine kinase, receptor, type 2Kidney-5.300.000
166ANK2ankyrin 2, neuronalKidney-5.290.000
167SLC12A3solute carrier family 12 (sodium/chloride transporter), member 3Kidney-5.290.000
168TFAP2Btranscription factor AP-2 beta (activating enhancer binding protein 2 beta)Kidney-5.290.000
169PPP1R1Aprotein phosphatase 1, regulatory (inhibitor) subunit 1AKidney-5.250.000
170MAPRE3microtubule-associated protein, RP/EB family, member 3Kidney+5.220.000
171ADAMTSL1ADAMTS-like 1Kidney+5.180.004
172AKR1C2aldo-keto reductase family 1, member C2Kidney+5.070.014
173TTC9tetratricopeptide repeat domain 9Kidney+5.030.000
174CLNKcytokine-dependent hematopoietic cell linkerKidney+4.990.002
175MCOLN2mucolipin 2Kidney+4.940.001
176ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2Kidney+4.810.000
177KLK4kallikrein-related peptidase 4Kidney+4.750.003
178CYP26A1cytochrome P450, family 26, subfamily A, polypeptide 1Kidney+4.650.010
179IGFBP1insulin-like growth factor binding protein 1Kidney+4.590.040
180SLC18A2solute carrier family 18 (vesicular monoamine transporter), member 2Kidney+4.580.007
181CRTAC1cartilage acidic protein 1Kidney+4.570.000
182CR1Lcomplement component (3b/4b) receptor 1-likeKidney+4.560.003
183ADRB1adrenoceptor beta 1Kidney+4.550.000
184CNTNAP5contactin associated protein-like 5Kidney+4.510.000
185GPR37G protein-coupled receptor 37 (endothelin receptor type B-like)Kidney+4.500.002
186NXPH2neurexophilin 2Kidney+4.480.022
187ELAVL2ELAV like neuron-specific RNA binding protein 2Kidney+4.420.001
188CDAcytidine deaminaseKidney+4.410.005
189SOX8SRY (sex determining region Y)-box 8Kidney+4.350.012
190KRTAP9-3keratin associated protein 9-3Kidney+4.350.000
191LMF1lipase maturation factor 1Kidney+4.330.012
192DMRT2doublesex and mab-3 related transcription factor 2Kidney+4.310.000
193DOCK10dedicator of cytokinesis 10Kidney+4.270.000
194ABHD11abhydrolase domain containing 11Kidney+4.230.004
195ST8SIA5ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5Kidney+4.170.002
196STAP1signal transducing adaptor family member 1Kidney+4.170.004
197SCDstearoyl-CoA desaturase (delta-9-desaturase)Kidney+4.160.000
198KRTAP5-8keratin associated protein 5-8Kidney+4.150.001
199C1orf53chromosome 1 open reading frame 53Kidney+4.110.009
200NRG2neuregulin 2Kidney+4.080.005
201TSPAN5tetraspanin 5Kidney+4.050.000
202SMOC1SPARC related modular calcium binding 1Kidney+4.010.002
203B4GALT6UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6Kidney+4.010.002
204LOC388820putative uncharacterized protein LOC388820Kidney+3.980.000
205VMA21VMA21 vacuolar H+-ATPase homolog (S. cerevisiae)Kidney+3.980.000
206ATP6V0D2ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2Kidney+3.980.000
207LOC441052uncharacterized LOC441052Kidney+3.950.002
208TIMD4T-cell immunoglobulin and mucin domain containing 4Kidney+3.920.000
209APOC1apolipoprotein C-IKidney+3.920.001
210ANKRD29ankyrin repeat domain 29Kidney+3.910.000
211KLK15kallikrein-related peptidase 15Kidney+3.910.001
212TTKTTK protein kinaseKidney+3.890.003
213PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)Kidney+3.890.000
214DSG2desmoglein 2Kidney+3.870.000
215BIN2bridging integrator 2Kidney+3.820.006
216KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologKidney+3.820.000
217PDE1Cphosphodiesterase 1C, calmodulin-dependent 70kDaKidney+3.810.000
218SEMA3Csema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3CKidney+3.800.000
219SLC29A4solute carrier family 29 (equilibrative nucleoside transporter), member 4Kidney+3.790.000
220FAM24Bfamily with sequence similarity 24, member BKidney+3.780.000
221Mar-10membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligaseKidney+3.750.000
222WBSCR17Williams-Beuren syndrome chromosome region 17Kidney+3.750.003
223ADCY1adenylate cyclase 1 (brain)Kidney+3.740.009
224CCDC34coiled-coil domain containing 34Kidney+3.730.000
225TIMM17Atranslocase of inner mitochondrial membrane 17 homolog A (yeast)Kidney+3.710.005
226SNTB1syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)Kidney+3.710.000
227RAB27BRAB27B, member RAS oncogene familyKidney+3.700.000
228RTN4RL2reticulon 4 receptor-like 2Kidney+3.690.001
229UNC80unc-80 homolog (C. elegans)Kidney+3.670.046
230GLCCI1glucocorticoid induced 1Kidney+3.660.000
231LOC283737uncharacterized LOC283737Kidney+3.660.002
232WDR63WD repeat domain 63Kidney+3.650.005
233CDH19cadherin 19, type 2Kidney+3.640.007
234MCOLN3mucolipin 3Kidney+3.600.000
235TPRG1tumor protein p63 regulated 1Kidney+3.580.001
236FBXO4F-box protein 4Kidney+3.560.005
237SLIT2slit guidance ligand 2Kidney+3.550.000
238EGFEM1PEGF-like and EMI domain containing 1, pseudogeneKidney+3.550.045
239ATP6V1G3ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3Kidney+3.550.000
240PYYpeptide YYKidney+3.550.006
241BACE2beta-site APP-cleaving enzyme 2Kidney+3.540.000
242PRAC1prostate cancer susceptibility candidate 1Kidney+3.530.033
243MCM10minichromosome maintenance 10 replication initiation factorKidney+3.530.022
244THRSPthyroid hormone responsiveKidney+3.520.000
245KCNQ4potassium channel, voltage gated KQT-like subfamily Q, member 4Kidney+3.520.015
246LINC00588long intergenic non-protein coding RNA 588Kidney+3.470.018
247RAB3BRAB3B, member RAS oncogene familyKidney+3.460.004
248ITGA6integrin, alpha 6Kidney+3.460.000
249PKIBprotein kinase (cAMP-dependent, catalytic) inhibitor betaKidney+3.450.026
250GRAPLGRB2-related adaptor protein-likeKidney+3.450.004
251PDGFRAplatelet-derived growth factor receptor, alpha polypeptideKidney+3.440.000
252RBM46RNA binding motif protein 46Kidney+3.440.024
253ANKRD22ankyrin repeat domain 22Kidney+3.410.000
254NTN1netrin 1Kidney+3.410.001
255CLGNcalmeginKidney+3.400.001
256HCRThypocretin (orexin) neuropeptide precursorKidney+3.390.003
257NBEAneurobeachinKidney+3.390.000
258LIMS1LIM and senescent cell antigen-like domains 1Kidney+3.370.000
259IL12Binterleukin 12BKidney+3.370.008
260TEX15testis expressed 15Kidney+3.360.038
261DCAF4L2DDB1 and CUL4 associated factor 4-like 2Kidney+3.360.036
262MTUS2microtubule associated tumor suppressor candidate 2Kidney+3.350.004
263IGF2BP3insulin-like growth factor 2 mRNA binding protein 3Kidney+3.350.007
264FAM13Cfamily with sequence similarity 13, member CKidney+3.340.000
265BAALC-AS2BAALC antisense RNA 2Kidney+3.330.000
266IL18interleukin 18Kidney+3.320.000
267CPNE2copine IIKidney+3.320.000
268FOXI1forkhead box I1Kidney+3.320.000
269SLC9A2solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2Kidney+3.320.010
270USTuronyl-2-sulfotransferaseKidney+3.280.012
271KBTBD12kelch repeat and BTB (POZ) domain containing 12Kidney+3.260.002
272GLDNgliomedinKidney+3.250.003
273TLCD2TLC domain containing 2Kidney+3.230.003
274LINC01300long intergenic non-protein coding RNA 1300Kidney+3.220.024
275DUSP4dual specificity phosphatase 4Kidney+3.220.001
276ASPMabnormal spindle microtubule assemblyKidney+3.220.030
277TP53I11tumor protein p53 inducible protein 11Kidney+3.210.001
278PSD3pleckstrin and Sec7 domain containing 3Kidney+3.200.000
279UBE2QL1ubiquitin-conjugating enzyme E2Q family-like 1Kidney+3.200.000
280CELF2CUGBP, Elav-like family member 2Kidney+3.190.000
281TRIM7tripartite motif containing 7Kidney+3.190.017
282ATL2atlastin GTPase 2Kidney+3.170.041
283RUNDC3ARUN domain containing 3AKidney+3.150.021
284LINC01289long intergenic non-protein coding RNA 1289Kidney+3.140.000
285GRB14growth factor receptor-bound protein 14Kidney+3.140.000
286TMPRSS15transmembrane protease, serine 15Kidney+3.140.016
287SLC4A5solute carrier family 4 (sodium bicarbonate cotransporter), member 5Kidney+3.140.009
288ATP8A2ATPase, aminophospholipid transporter, class I, type 8A, member 2Kidney+3.140.006
289KCNH2potassium channel, voltage gated eag related subfamily H, member 2Kidney+3.140.022
290INHBBinhibin, beta BKidney+3.130.005
291PPP1R12Bprotein phosphatase 1, regulatory subunit 12BKidney+3.130.035
292VWA5B1von Willebrand factor A domain containing 5B1Kidney+3.120.009
293PXKPX domain containing serine/threonine kinaseKidney+3.100.000
294TRBV27T cell receptor beta variable 27Kidney+3.100.000
295GINS2GINS complex subunit 2 (Psf2 homolog)Kidney+3.100.003
296SLC35D3solute carrier family 35, member D3Kidney+3.100.025
297LOC340184uncharacterized LOC340184Kidney+3.090.006
298CKMT2creatine kinase, mitochondrial 2 (sarcomeric)Kidney+3.080.000
299SYNGR3synaptogyrin 3Kidney+3.080.002
300KIF21Akinesin family member 21AKidney+3.060.002
301ABCC4ATP-binding cassette, sub-family C (CFTR/MRP), member 4Kidney+3.060.000
302CCND1cyclin D1Kidney+3.060.034
303UMPSuridine monophosphate synthetaseKidney+3.060.002
304ENOX2ecto-NOX disulfide-thiol exchanger 2Kidney+3.040.008
305TRDV3T cell receptor delta variable 3Kidney+3.040.036
306MSI2musashi RNA-binding protein 2Kidney+3.030.010
307ATP6V0A4ATPase, H+ transporting, lysosomal V0 subunit a4Kidney+3.020.000
308BCAS4breast carcinoma amplified sequence 4Kidney+3.010.040
309ADGRF5adhesion G protein-coupled receptor F5Kidney+3.010.000
310ERP27endoplasmic reticulum protein 27Kidney+3.000.000

Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for genes affiliated with Renal Oncocytoma

About this section

Pathways related to Renal Oncocytoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.8KIT, MME
29.2EPCAM, KIT, MME

GO Terms for genes affiliated with Renal Oncocytoma

About this section

Cellular components related to Renal Oncocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1basolateral plasma membraneGO:00163239.3CDH16, CLDN8, DLG2, EPCAM
2integral component of plasma membraneGO:00058879.2CAV1, CDH16, EPCAM, MME, MST1R
3plasma membraneGO:00058866.6CAV1, CDH16, CLDN8, DLG2, EPCAM, FLCN

Biological processes related to Renal Oncocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cellular response to peptide hormone stimulusGO:00713759.8CAV1, MAX
2stem cell differentiationGO:00488639.6EPCAM, KIT

Molecular functions related to Renal Oncocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein complex bindingGO:00324039.0EPCAM, FLCN, MAX

Sources for Renal Oncocytoma

About this section
2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet