MCID: RNL017
MIFTS: 44

Renal Oncocytoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Oncocytoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell. more...

MalaCards: Renal Oncocytoma, also known as renal epithelial oncocytic tumor, is related to papillary carcinoma and adenoma. An important gene associated with Renal Oncocytoma is MT-ND3 (mitochondrially encoded NADH dehydrogenase 3), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cell-cell junction organization. The compounds reticulin and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and lung.

Description from OMIM:46 553000

Aliases & Classifications for Renal Oncocytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 46OMIM, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal oncocytoma 8 42 10
renal epithelial oncocytic tumor 8
oncocytoma of kidney 8
hurthle cell tumor 60
oncocytoma kidney 42
oncocytoma, renal 60
oncocytoma renal 42


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Disease Ontology8 DOID:6245
OMIM46 553000
SNOMED-CT56 254922006
NCIt39 C4526
MeSH34 C537750

Related Diseases for Renal Oncocytoma

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17GeneCards, 18GeneDecks
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Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.5S100A1, KRT14, KRT7
2adenoma30.4KRT14, S100A1, KRT7
3renal clear cell carcinoma30.4S100A1, PVALB, CDH16, CLDN7, KRT7, VIM
4angiomyolipoma30.3S100A1, VIM
5oxyphilic adenoma30.2KRT7, CLDN7, FLCN, CDH16, PVALB, S100A1
6hepatocellular carcinoma30.0CTAG1B, KRT14, MAGEA3, MAGEA4, KRT7
7melanoma30.0MAGEA3, MAGEA4, KRT14, CTAG1B, VIM, S100A1
8adenocarcinoma30.0KRT14, MAGEA4, CTAG1B, CLDN7, MAGEA3, KRT7
9renal cell carcinoma10.9
10eosinophilic variant of chromophobe renal cell carcinoma10.3
11familial renal oncocytoma10.3
12papillary renal cell carcinoma10.3
13renal adenoma10.3
14tuberous sclerosis10.2
15hypertension10.2
16prostatitis10.2
17renal hypertension10.2
18thyroid hurthle cell carcinoma10.2
19bullous pemphigoid10.0
20perinephritis10.0
21bone carcinoma10.0
22coronary aneurysm10.0
23small cell carcinoma10.0
24duodenitis10.0
25bronchogenic carcinoma10.0
26chromophobe adenoma10.0
27diffuse large b-cell lymphoma10.0
28osteoporosis10.0
29amyloidosis10.0
30colon adenocarcinoma10.0
31conjunctivitis10.0
32cystic kidney10.0
33endocarditis10.0
34glomerulonephritis10.0
35hemangioblastoma10.0
36nephrotic syndrome10.0
37renal pelvis carcinoma10.0
38vasculitis10.0
39pheochromocytoma10.0
40mixed cell type cancer10.0KRT7
41dysgerminoma10.0KRT7
42thymus cancer10.0KRT7
43craniopharyngioma10.0KRT14
44papilloma10.0KRT14
45endometrial carcinoma10.0KRT7
46ductal carcinoma in situ10.0KRT14
47lipoma10.0S100A1
48nephrogenic adenoma10.0KRT7, S100A1
49cystadenoma10.0KRT7
50metanephric adenoma10.0KRT7

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to renal oncocytoma

Clinical Features for Renal Oncocytoma

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46OMIM
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Clinical features from OMIM:

553000

Drugs & Therapeutics for Renal Oncocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Renal Oncocytoma

Drug clinical trials:

Search ClinicalTrials for Renal Oncocytoma

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Search CenterWatch for Renal Oncocytoma

Genetic Tests for Renal Oncocytoma

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Anatomical Context for Renal Oncocytoma

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32MalaCards
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MalaCards organs/tissues related to Renal Oncocytoma:

32
Kidney, Liver, Lung, B cells, Colon, Prostate, Bone, Breast, Salivary gland

Animal Models for Renal Oncocytoma or affiliated genes

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Publications for Renal Oncocytoma

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50PubMed
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Articles related to Renal Oncocytoma:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma. (23765540)
2013
2
Segmental enhancement inversion of small renal oncocytoma: differences in prevalence according to tumor size. (23617489)
2013
3
Papillary renal cell carcinoma embedded in an oncocytoma: Case report of a rare combined tumour of the kidney. (23914273)
2013
4
The Management Of A Concomitant Renal Oncocytoma, Giant Coronary And Bilateral Common Iliac Artery Aneurysms. (24200531)
2013
5
Small cell variant of renal oncocytoma with liver metastases: a case report. (23775024)
2013
6
Clinically undiagnosed prostate carcinoma metastatic to renal oncocytoma. (22754705)
2012
7
A new translocation between chromosomes 6 and 9 helps to establish diagnosis of renal oncocytoma. (20952287)
2011
8
Case report of a symptomatic giant renal oncocytoma. (22096690)
2011
9
Proliferation of myofibroblasts in the stroma of renal oncocytoma. (20412129)
2010
10
Clonal expansion of mutated mitochondrial DNA is associated with tumor formation and complex I deficiency in the benign renal oncocytoma. (18156159)
2008
11
ARPP protein is selectively expressed in renal oncocytoma, but rarely in renal cell carcinomas. (17206105)
2007
12
Diagnostic value of cytokeratin 7 and parvalbumin in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16927643)
2006
13
Giant renal oncocytoma masquerading as infiltrating renal cell carcinoma: case report and literature review. (17892235)
2006
14
Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. (17145811)
2006
15
Insertion (8;11) in a renal oncocytoma with multifocal transformation to chromophobe renal cell carcinoma. (16337860)
2005
16
Expression of kidney-specific cadherin distinguishes chromophobe renal cell carcinoma from renal oncocytoma. (15712178)
2005
17
Changing concepts in the management of renal oncocytoma. (11992832)
2002
18
Extracellular matrix globules in renal oncocytoma. (11358010)
2001
19
Ultrastructural observations on mitochondria and microvesicles in renal oncocytoma, chromophobe renal cell carcinoma, and eosinophilic variant of conventional (clear cell) renal cell carcinoma. (10976699)
2000
20
Renal oncocytoma: diagnostic and therapeutic aspects. (10999712)
2000
21
Cathepsin H expression distinguishes oncocytomas from renal cell carcinomas. (10769721)
2000
22
Bilateral renal oncocytoma in a Greyhound dog. (10714650)
2000
23
Metastatic renal oncocytoma: A case report and review of the literature. (10473728)
1999
24
Absence of HinfI Restriction Abnormalities in Renal Oncocytoma Mitochondrial DNA. (10851289)
1999
25
Rare association of unilateral renal oncocytoma and angiomyolipoma. (9060091)
1997
26
Renal oncocytoma treated by surgical enucleation: a case report. (8752541)
1996
27
Renal oncocytoma: magnetic resonance imaging characteristics. (8583594)
1996
28
Renal oncocytoma. Pathological evaluation and clinical implications. (8713569)
1996
29
Renal oncocytoma with a translocation t(9;11)(p23;q13). (8015093)
1994
30
33-year follow-up after simple excision of a giant renal oncocytoma with calcifications: case report and review of the literature. (1555842)
1992
31
Surgical repair of a celiac axis aneurysm and renal oncocytoma: a single case report. (1467186)
1992
32
Case report: characteristic ultrasonographic appearance of a large renal oncocytoma. (2070589)
1991
33
Renal oncocytoma: report of a case with bilateral multifocal oncocytomas. (2224628)
1990
34
Renal oncocytoma: a clinicopathologic study of a case with review of the literature. (2650725)
1989
35
Renal oncocytoma. A phenotypic and genotypic entity of renal parenchymal tumors. (2719081)
1989
36
Renal oncocytoma: a benign tumor often misdiagnosed as malignant. Case reports and a diagnostic protocol. (3053030)
1988
37
CT scan in renal oncocytoma. (3427323)
1987
38
Renal oncocytoma. (3947853)
1986
39
Unilateral renal oncocytoma: a case report. (3818213)
1986
40
Chromosome anomalies suggestive of malignant transformation in bilateral renal oncocytoma. (3761454)
1986
41
Partial nephrectomy for a renal oncocytoma associated with tuberous sclerosis. (3968746)
1985
42
Renal oncocytoma: new observations. (6473802)
1984
43
Renal oncocytoma: a diagnostic and therapeutic dilemma. (6492276)
1984
44
Renal oncocytoma: case report. (6582859)
1984
45
Renal oncocytoma. A review of the literature and report of an unusual multicentric case. (6402840)
1983
46
Renal oncocytoma associated with diffuse lymphoma. (6623786)
1983
47
Computed tomography of renal oncocytoma. (6604427)
1983
48
Renal oncocytoma (pathology, preoperative diagnosis, therapy). (7145986)
1982
49
A case of bilateral renal oncocytoma. (7120567)
1982
50
Renal oncocytoma: ten-year follow-up. (7245454)
1981

Genetic Variations for Renal Oncocytoma

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Expression for genes affiliated with Renal Oncocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Oncocytoma

Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for genes affiliated with Renal Oncocytoma

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12EMD Millipore, 53Reactome
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Pathways related to Renal Oncocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KRT7, KRT14, VIM
2
Hide members
10.1KRT14, CLDN7, CLDN8

Compounds for genes affiliated with Renal Oncocytoma

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44Novoseek, 24HMDB
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Compounds related to Renal Oncocytoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1reticulin4410.3KRT7, VIM
22-methoxyethanol4410.2KRT14, S100A1, VIM
3mucicarmine4410.2VIM, S100A1, KRT14, KRT7
4hematoxylin4410.1VIM, S100A1, KRT14, KRT7
5b 7234410.0KRT7, S100A1, VIM
6toluidine449.9S100A1, VIM
7paraffin449.9VIM, PVALB, S100A1, MAGEA3, KRT14, KRT7
8iron44 2410.8KRT7, KRT14, EGLN2, S100A1, PVALB, VIM

GO Terms for genes affiliated with Renal Oncocytoma

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16Gene Ontology
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Cellular components related to Renal Oncocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.1KRT7, KRT14, VIM

Products for genes affiliated with Renal Oncocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renal Oncocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet