MCID: RNL017
MIFTS: 44

Renal Oncocytoma malady

Nephrological diseases, Cancer diseases categories

Summaries for Renal Oncocytoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 A renal oncocytoma is a tumour of the kidney made up of oncocytes, a special kind of cell. more...

MalaCards: Renal Oncocytoma, also known as renal epithelial oncocytic tumor, is related to papillary carcinoma and adenoma. An important gene associated with Renal Oncocytoma is MT-ND3 (mitochondrially encoded NADH dehydrogenase 3), and among its related pathways are Cytoskeleton remodeling Keratin filaments and Cell-cell junction organization. The compounds reticulin and 2-methoxyethanol have been mentioned in the context of this disorder. Affiliated tissues include kidney, liver and colon.

Description from OMIM:46 553000

Aliases & Classifications for Renal Oncocytoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 46OMIM, 56SNOMED-CT, 39NCIt, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Nephrological diseases


Aliases & Descriptions:

renal oncocytoma 8 42 10
renal epithelial oncocytic tumor 8
oncocytoma of kidney 8
hurthle cell tumor 60
oncocytoma kidney 42
oncocytoma, renal 60
oncocytoma renal 42


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Disease Ontology8 DOID:6245
OMIM46 553000
SNOMED-CT56 254922006
NCIt39 C4526
MeSH34 C537750

Related Diseases for Renal Oncocytoma

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17GeneCards, 18GeneDecks
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Diseases in the Renal Oncocytoma family:

Familial Renal Oncocytoma

Diseases related to Renal Oncocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 86)
idRelated DiseaseScoreTop Affiliating Genes
1papillary carcinoma30.5S100A1, KRT14, KRT7
2adenoma30.4KRT14, S100A1, KRT7
3renal clear cell carcinoma30.4S100A1, PVALB, CDH16, CLDN7, KRT7, VIM
4angiomyolipoma30.3S100A1, VIM
5oxyphilic adenoma30.2KRT7, CLDN7, FLCN, CDH16, PVALB, S100A1
6hepatocellular carcinoma30.0CTAG1B, KRT14, MAGEA3, MAGEA4, KRT7
7melanoma30.0MAGEA3, MAGEA4, KRT14, CTAG1B, VIM, S100A1
8adenocarcinoma30.0KRT14, MAGEA4, CTAG1B, CLDN7, MAGEA3, KRT7
9renal cell carcinoma10.9
10eosinophilic variant of chromophobe renal cell carcinoma10.3
11familial renal oncocytoma10.3
12papillary renal cell carcinoma10.3
13renal adenoma10.3
14tuberous sclerosis10.2
15hypertension10.2
16prostatitis10.2
17renal hypertension10.2
18thyroid hurthle cell carcinoma10.2
19bullous pemphigoid10.0
20perinephritis10.0
21bone carcinoma10.0
22coronary aneurysm10.0
23small cell carcinoma10.0
24duodenitis10.0
25bronchogenic carcinoma10.0
26chromophobe adenoma10.0
27diffuse large b-cell lymphoma10.0
28osteoporosis10.0
29amyloidosis10.0
30colon adenocarcinoma10.0
31conjunctivitis10.0
32cystic kidney10.0
33endocarditis10.0
34glomerulonephritis10.0
35hemangioblastoma10.0
36nephrotic syndrome10.0
37renal pelvis carcinoma10.0
38vasculitis10.0
39pheochromocytoma10.0
40mixed cell type cancer10.0KRT7
41dysgerminoma10.0KRT7
42thymus cancer10.0KRT7
43craniopharyngioma10.0KRT14
44papilloma10.0KRT14
45endometrial carcinoma10.0KRT7
46ductal carcinoma in situ10.0KRT14
47lipoma10.0S100A1
48nephrogenic adenoma10.0KRT7, S100A1
49cystadenoma10.0KRT7
50metanephric adenoma10.0KRT7

Graphical network of the top 20 diseases related to Renal Oncocytoma:



Diseases related to renal oncocytoma

Clinical Features for Renal Oncocytoma

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46OMIM
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Clinical features from OMIM:

553000

Drugs & Therapeutics for Renal Oncocytoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Renal Oncocytoma

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Genetic Tests for Renal Oncocytoma

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Anatomical Context for Renal Oncocytoma

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32MalaCards
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MalaCards organs/tissues related to Renal Oncocytoma:

32
Kidney, Liver, Colon, Lung, Prostate, B cells, Bone, Salivary gland, Breast

Animal Models for Renal Oncocytoma or affiliated genes

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Publications for Renal Oncocytoma

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50PubMed
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Articles related to Renal Oncocytoma:

(show top 50)    (show all 360)
idTitleAuthorsYear
1
Renal cell carcinoma metastasis to a contralateral oncocytoma in a patient presenting with bilateral synchronous renal tumors. (24035154)
2013
2
BCA2 is differentially expressed in renal oncocytoma: an analysis of 158 renal neoplasms. (23242606)
2013
3
Composite oncocytoma and papillary renal cell carcinoma of the kidney treated by partial nephrectomy: a case report. (21666986)
2011
4
Typical renal oncocytoma. (21874809)
2011
5
The impact of germline BHD mutation on histological concordance and clinical treatment of patients with bilateral renal masses and known unilateral oncocytoma. (21496834)
2011
6
MRI features of renal oncocytoma and chromophobe renal cell carcinoma. (21098174)
2010
7
Genomic expression and single-nucleotide polymorphism profiling discriminates chromophobe renal cell carcinoma and oncocytoma. (20462447)
2010
8
Diagnostic usefulness of fluorescent cytogenetics in differentiating chromophobe renal cell carcinoma from renal oncocytoma: a validation study combining metaphase and interphase analyses. (20023267)
2010
9
Can renal oncocytoma be distinguished from chromophobe renal cell carcinoma by the presence of fibrous capsule? (20024582)
2010
10
Renal oncocytoma revisited: a clinicopathological study of 109 cases with emphasis on problematic diagnostic features. (21166703)
2010
11
Paraneoplastic hypertension associated with renal oncocytoma: management with cryoablation. (18372030)
2009
12
CCND1 rearrangements and cyclin D1 overexpression in renal oncocytomas: frequency, clinicopathologic features, and utility in differentiation from chromophobe renal cell carcinoma. (19386349)
2009
13
Oncocytic renal cell carcinoma with immunohistochemical properties of renal oncocytoma. (18947937)
2009
14
Renal oncocytoma: clinical experience of Taipei Veterans General Hospital. (18490230)
2008
15
Renal oncocytoma with and without intravascular extension into the branches of renal vein have the same morphological, immunohistochemical, and genetic features. (18066590)
2008
16
Renal oncocytoma: a case report and short review of the literature. (19013370)
2008
17
Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma. (18413815)
2008
18
An 11-bp duplication in the promoter region of the VHL gene in a patient with cerebellar hemangioblastoma and renal oncocytoma. (17437055)
2007
19
Renal oncocytoma, yet another tumour that does not fit in the dualistic benign/malignant paradigm? (17557864)
2007
20
Renal oncocytoma displaying intense activity on 18F-FDG PET. (16357422)
2006
21
Multilocular cystic renal oncocytoma. (16443744)
2006
22
Caveolin-1 immunohistochemical analysis in differentiating chromophobe renal cell carcinoma from renal oncocytoma. (16613342)
2006
23
Lack of mutation of the folliculin gene in sporadic chromophobe renal cell carcinoma and renal oncocytoma. (14961590)
2004
24
Renal oncocytoma with a novel chromosomal rearrangement, der(13)t(13;16)(p11;p11), associated with a renal cell carcinoma. (11865018)
2002
25
Cytokeratin 20 immunoreactivity in renal oncocytomas. (11410616)
2001
26
Loss of chromosomes 1 and X in a renal oncocytoma: implications for a possible pseudoautosomal tumor suppressor locus. (11188769)
2000
27
Fine-needle aspiration biopsy of chromophobe renal cell carcinoma and oncocytoma: comparison of cytomorphologic features. (10385448)
1999
28
Renal oncocytoma of the native kidney after renal transplantation. (9569961)
1998
29
Bilateral multiple renal oncocytomas and cysts associated with a constitutional translocation (8;9)(q24.1;q34.3) and a rare constitutional VHL missense substitution. (9523203)
1998
30
Hyaline globules in renal cell carcinomas and oncocytomas. (9104937)
1997
31
An incidental finding--bilateral multifocal renal oncocytoma. (9175065)
1997
32
Involvement of the chromosomal region 11q13 in renal oncocytoma: case report and literature review. (9109935)
1997
33
Renal oncocytoma with t(5;12;11), der(1)1;8) and add(19): "true" oncocytoma or chromophobe adenoma? (9389566)
1997
34
Fine mapping of the human renal oncocytoma-associated translocation (5;11)(q35;q13) breakpoint. (9216713)
1997
35
Renal oncocytoma: preoperative diagnosis using technetium 99m sestamibi imaging. (8693649)
1996
36
A singular case of near-haploid stemline karyotype in a renal oncocytoma. (8956867)
1996
37
Renal oncocytoma containing "chromophobe" cells. (8564750)
1995
38
Renal oncocytoma associated with obliterative renal fibrosis. Report of a case with histologic, immunohistochemical, and ultrastructural studies. (7944887)
1994
39
Fine needle aspiration diagnosis of renal oncocytoma. A mathematical morphologic approach. (8347263)
1993
40
Renal oncocytoma. (8493754)
1993
41
Preoperative diagnosis of bilateral renal oncocytoma by needle aspiration cytology. A case report. (1950327)
1991
42
Renal oncocytoma: prognosis and treatment. (2226597)
1990
43
Nucleolar organizing regions in renal cell carcinoma, renal oncocytoma and renal adenoma. (2487043)
1989
44
Renal oncocytoma: a report of two cases with immunohistochemical evaluation. (3366453)
1988
45
Further evidence that renal oncocytoma has malignant potential. (3343746)
1988
46
Spontaneous rupture of renal oncocytoma with acute abdomen. Case report. (3213373)
1988
47
Renal oncocytoma: angiographic studies in three cases. (6490588)
1984
48
Renal oncocytoma: report of two cases. (6868145)
1983
49
Renal oncocytoma: further observations and literature review. (7022993)
1980-1981
50
Renal oncocytoma. Study of eight cases. (473472)
1979

Genetic Variations for Renal Oncocytoma

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Expression for genes affiliated with Renal Oncocytoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Oncocytoma

Search GEO for disease gene expression data for Renal Oncocytoma.

Pathways for genes affiliated with Renal Oncocytoma

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12EMD Millipore, 53Reactome
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Pathways related to Renal Oncocytoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1KRT7, KRT14, VIM
2
Hide members
10.1KRT14, CLDN7, CLDN8

Compounds for genes affiliated with Renal Oncocytoma

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44Novoseek, 24HMDB
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Compounds related to Renal Oncocytoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1reticulin4410.3KRT7, VIM
22-methoxyethanol4410.2KRT14, S100A1, VIM
3mucicarmine4410.2KRT7, KRT14, S100A1, VIM
4hematoxylin4410.1VIM, S100A1, KRT14, KRT7
5b 7234410.0VIM, S100A1, KRT7
6toluidine449.9S100A1, VIM
7paraffin449.9VIM, PVALB, S100A1, MAGEA3, KRT14, KRT7
8iron44 2410.8VIM, PVALB, S100A1, EGLN2, KRT14, KRT7

GO Terms for genes affiliated with Renal Oncocytoma

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16Gene Ontology
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Cellular components related to Renal Oncocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00588210.1KRT7, KRT14, VIM

Products for genes affiliated with Renal Oncocytoma

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Sources for Renal Oncocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet