MCID: RNL011
MIFTS: 43

Renal Osteodystrophy malady

Rare diseases, Nephrological diseases, Bone diseases categories

Aliases & Classifications for Renal Osteodystrophy

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Renal Osteodystrophy, Aliases & Descriptions:

Name: Renal Osteodystrophy 9 11 43 60
 
Renal Rickets 9 41 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Bone diseases


External Ids:

Disease Ontology9 DOID:13068
MeSH33 D012080
ICD9CM27 588.0
ICD1025 N25.0

Summaries for Renal Osteodystrophy

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Wikipedia:63 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards based summary: Renal Osteodystrophy, also known as renal rickets, is related to osteonecrosis and kidney disease. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and FGF signaling pathway. The compounds pyridinoline and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Related Diseases for Renal Osteodystrophy

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Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 81)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis31.2BGLAP
2kidney disease30.7TNFRSF11B, CASR, FGF23
3hyperostosis30.6BGLAP, FGF23
4uremia30.6TNFRSF11B, PTH, CASR
5pseudohypoparathyroidism30.5PTH, BGLAP
6metabolic acidosis30.4PTH, BGLAP
7rickets30.4CASR, PTH, BGLAP
8osteitis fibrosa30.4BGLAP, PTH, CASR
9calcinosis30.1PTH, CASR, FGF23
10arthritis30.0ACP5, TNFRSF11B, BGLAP
11osteomalacia30.0BGLAP, TNFRSF11B, PTH, CASR, FGF23
12hyperparathyroidism29.9FGF23, CASR, ACP5, PTH, TNFRSF11B, BGLAP
13hypercalcemia29.8BGLAP, TNFRSF11B, PTH, CASR, FGF23
14primary hyperparathyroidism29.3BGLAP, PTH, ACP5, CASR, FGF23
15chronic kidney failure28.9BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
16peritonitis10.7
17camurati-engelmann disease10.4BGLAP
18hypervitaminosis d10.4FGF23
19cervicitis10.4
20synovitis10.4TNFRSF11B
21spinal stenosis10.3
22slipped capital femoral epiphysis10.3
23pseudohypoparathyroidism, type ib10.3BGLAP, PTH
24end stage renal failure10.2
25hypophosphatasia10.2
26parathyroid gland disease10.2PTH, CASR
27parathyroid carcinoma10.2PTH, CASR
28goiter10.2PTH, BGLAP
29hypophosphatemic rickets, x-linked dominant10.2FGF23, PTH
30parathyroid adenoma10.2PTH, CASR
31multiple endocrine neoplasia 110.2CASR, PTH
32fibrous dysplasia10.2BGLAP, FGF23
33hyperostosis, endosteal10.2PTH, TNFRSF11B
34primary hyperoxaluria10.1PTH, BGLAP
35osteopetrosis10.1TNFRSF11B, BGLAP
36bone cancer10.1TNFRSF11B, BGLAP
37rheumatic disease10.1BGLAP, TNFRSF11B
38cushing's syndrome10.1BGLAP, TNFRSF11B
39achondroplasia10.1
40psoriatic arthritis10.1
41avascular necrosis of the femoral head10.1
42bone fracture10.1
43myelofibrosis10.1
44fanconi syndrome10.1
45polycystic kidney disease10.1
46blount's disease10.1
47brachydactyly10.1
48pancytopenia10.1
49cranial nerve palsy10.1
50facial paralysis10.1

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Symptoms for Renal Osteodystrophy

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Drugs & Therapeutics for Renal Osteodystrophy

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Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

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Anatomical Context for Renal Osteodystrophy

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MalaCards organs/tissues related to Renal Osteodystrophy:

31
Bone, Kidney, Bone marrow, Cortex, Spinal cord, Testes

Animal Models for Renal Osteodystrophy or affiliated genes

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MGI Mouse Phenotypes related to Renal Osteodystrophy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFRSF11B, PTH, ACP5, FGF23
2MP:00053907.6FGF23, CASR, ACP5, PTH, TNFRSF11B
3MP:00053877.6FGF23, CASR, ACP5, PTH, TNFRSF11B
4MP:00053977.3TNFRSF11B, PTH, ACP5, CASR, FGF23

Publications for Renal Osteodystrophy

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Articles related to Renal Osteodystrophy:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Severe renal osteodystrophy in a pediatric patient with end-stage renal disease: Sagliker syndrome? (23026501)
2013
2
The influence of medical and nonmedical factors to the progression of renal osteodystrophy. (20102101)
2009
3
Chronic pachymeningitis and bilateral facial paralysis secondary to renal osteodystrophy. (18347262)
2008
4
Clinical and economic burden of fractures in patients with renal osteodystrophy. (17474555)
2007
5
Renal osteodystrophy, phosphate homeostasis, and vascular calcification. (17635820)
2007
6
Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients. (15665550)
2005
7
Utilization of bone histomorphometry in renal osteodystrophy: demonstration of a new approach using data from a prospective study of lanthanum carbonate. (15730056)
2005
8
Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease. (15882311)
2005
9
Localized jaw enlargement in renal osteodystrophy: report of a case and review of the literature. (14716259)
2004
10
New aspects in the management of renal osteodystrophy]. (15669206)
2004
11
Radiologic features of renal osteodystrophy in a patient with "normal" bone mineralization. (12970649)
2003
12
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
13
Renal osteodystrophy. (12041521)
2002
14
Adynamic renal osteodystrophy: is there a problem? (11518793)
2001
15
Management of secondary hyperparathyroidism: the gap between diagnosis and treatment. The Renal Osteodystrophy Multicenter Enquiry. (10981485)
2000
16
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
17
High frequency of iron bone deposits in a Mexican population with renal osteodystrophy. (9568820)
1998
18
Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy: what do we have, what do we need? (9568817)
1998
19
Magnetic resonance imaging of renal osteodystrophy in children. (9361047)
1997
20
Myelofibrosis secondary to renal osteodystrophy. (8730443)
1996
21
Secondary hyperparathyroidism and renal osteodystrophy. (7728664)
1995
22
Detection of subtle aluminum-related renal osteodystrophy. (7683072)
1993
23
Renal osteodystrophy in diabetic patients. (8355457)
1993
24
Comparison of renal osteodystrophy in patients undergoing continuous ambulatory peritoneal dialysis and hemodialysis. (8399637)
1993
25
Renal osteodystrophy and hypercalcemia. (8512774)
1993
26
PTH and bone markers of renal osteodystrophy in predialysis chronic renal failure. (1300330)
1992
27
Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. (1453606)
1992
28
The radiographic spectrum of renal osteodystrophy. (1986484)
1991
29
Prevention of renal osteodystrophy. (1813786)
1991
30
Diagnostic evaluation of plasma free gamma-carboxyglutamic acid in maintenance hemodialytic patients with renal osteodystrophy]. (2082053)
1990
31
Use of oral and parenteral calcitriol in the treatment of renal osteodystrophy. (2214548)
1990
32
Is renal osteodystrophy rare in the tropics? (2362644)
1990
33
Efficacy of calcium carbonate and low-dose vitamin D/1,25(OH)2D3 in reducing the risk of developing renal osteodystrophy in children on continuous ambulatory peritoneal dialysis. (2088463)
1990
34
Diagnosis of renal osteodystrophy with the Jamshidi needle biopsy. (2750179)
1989
35
51Cr-EDTA/99Tcm-MDP ratio: a simple non-invasive method for assessing renal osteodystrophy. (2496884)
1989
36
1,25 (OH)2 vitamin D3 deficiency and renal osteodystrophy: should its well-accepted pathogenetic role in secondary hyperparathyroidism lead to its systematic preventive therapeutic use? (3126450)
1987
37
Primary bone oxalosis: the roles of oxalate deposits and renal osteodystrophy. (3593609)
1987
38
Behavior of the vitamin D endocrine system in the development of renal osteodystrophy. (3299575)
1986
39
Renal osteodystrophy in asymptomatic hemodialysis patients: evidence of a sex-dependent distribution and predictive value of serum aluminum measurements. (3812472)
1986
40
The effect of hemodialysis, vitamin D metabolites and renal transplantation on the skeletal demineralization associated with renal osteodystrophy: a computerized histomorphometric analysis. (3542321)
1986
41
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
42
Total parathyroidectomy and parathyroid autograft for renal osteodystrophy: analysis of the cause of failure. (4013363)
1985
43
Observations on computerized quantitative bone scintigraphy in renal osteodystrophy. (6437823)
1984
44
Consequences of avascular necrosis of the femoral head in aluminium-related renal osteodystrophy and the role of endochondral ossification in the repair process. (6402524)
1983
45
Caring for patients with renal osteodystrophy. (6552189)
1983
46
Bone aluminum deposition in renal osteodystrophy. (6185842)
1983
47
Therapeutic effects of 25-hydroxycholecalciferol and sodium etidronate on renal osteodystrophy. (6820473)
1982
48
Renal osteodystrophy in children with chronic renal failure: an unexpectedly common and incapactating complication. (6982452)
1982
49
Radiographic interpretation of the mandibular angular cortex: a diagnostic tool in metabolic bone loss. Part II. Renal osteodystrophy. (6954448)
1982
50
Renal osteodystrophy presenting as periurethral abscess. (7147513)
1982

Variations for Renal Osteodystrophy

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Expression for genes affiliated with Renal Osteodystrophy

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Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

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Pathways related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BGLAP, PTH
29.5FGF23, BGLAP
39.0ACP5, TNFRSF11B
49.0ACP5, TNFRSF11B
5
Show member pathways
RANKL/RANK Signaling Pathway36
Apoptosis and survival APRIL and BAFF signaling58
9.0ACP5, TNFRSF11B
69.0PTH, TNFRSF11B, BGLAP
78.9FGF23, PTH, TNFRSF11B

Compounds for genes affiliated with Renal Osteodystrophy

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Compounds related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1pyridinoline4310.3TNFRSF11B
2calcium carbonate439.9PTH, BGLAP
322-oxacalcitriol439.9BGLAP, CASR
4deflazacort439.8TNFRSF11B, BGLAP
5etidronate439.8TNFRSF11B, BGLAP
6thiazide439.8CASR, BGLAP
7teriparatide43 1210.8TNFRSF11B, BGLAP
8ibandronate43 1210.7BGLAP, TNFRSF11B
9strontium439.7TNFRSF11B, CASR
10vitamin k2439.7TNFRSF11B, BGLAP
11risedronate43 49 28 59 1213.7BGLAP, TNFRSF11B
12hydrochlorothiazide43 28 49 24 1213.6BGLAP, CASR
13zoledronic acid439.5TNFRSF11B, BGLAP
14tartrate439.5ACP5, BGLAP
15sevelamer439.4FGF23, CASR, BGLAP
16ns 39843 5910.4TNFRSF11B, BGLAP
17tibolone439.4BGLAP, ACP5
18infliximab43 49 1211.4TNFRSF11B, BGLAP
19alendronate43 49 1211.4BGLAP, TNFRSF11B, PTH
20thyroxine43 2410.3PTH, TNFRSF11B, BGLAP
21pmma439.3TNFRSF11B, ACP5
22tamoxifen43 49 28 1212.2PTH, TNFRSF11B, BGLAP
23raloxifene43 49 28 1212.1TNFRSF11B, BGLAP
24clodronate43 49 1211.0ACP5, TNFRSF11B, BGLAP
25forskolin43 49 1211.0TNFRSF11B, PTH, CASR
26titanium439.0ACP5, TNFRSF11B, BGLAP
27azathioprine43 2 49 1212.0BGLAP, TNFRSF11B, ACP5
28pamidronate43 49 1210.9BGLAP, TNFRSF11B, PTH, CASR
29arginine438.9BGLAP, PTH, CASR, FGF23
30sodium43 249.8TNFRSF11B, PTH, CASR
31deoxypyridinoline438.6BGLAP, TNFRSF11B, PTH, ACP5
32hydroxyproline43 24 1210.6BGLAP, TNFRSF11B, PTH, ACP5
33procollagen438.6ACP5, PTH, TNFRSF11B, BGLAP
34estradiol43 24 1210.6BGLAP, TNFRSF11B, PTH, ACP5
35dexamethasone43 49 28 1211.5BGLAP, TNFRSF11B, PTH, ACP5
36cyclosporin a43 28 5910.4CASR, ACP5, TNFRSF11B, BGLAP
37heparin43 28 24 1211.4FGF23, ACP5, TNFRSF11B, BGLAP
38nitric oxide43 24 1210.4TNFRSF11B, PTH, ACP5, CASR
39cysteine438.3CASR, ACP5, TNFRSF11B, BGLAP
40pge2438.1BGLAP, TNFRSF11B, PTH, ACP5, CASR
41estrogen438.0BGLAP, TNFRSF11B, PTH, ACP5, CASR
42hydroxyapatite438.0BGLAP, TNFRSF11B, ACP5, CASR, FGF23
43tyrosine437.9TNFRSF11B, PTH, ACP5, CASR, FGF23
4425-hydroxyvitamin d437.6FGF23, BGLAP, TNFRSF11B, PTH, ACP5, CASR
45phosphorus437.6BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
461,25 dihydroxy vitamin d3437.6BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
47calcitriol43 59 24 1210.6BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
48vitamin d437.6BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
49creatinine437.6BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
50calcium43 49 24 1210.5FGF23, CASR, ACP5, PTH, TNFRSF11B, BGLAP

GO Terms for genes affiliated with Renal Osteodystrophy

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Cellular components related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.5FGF23, PTH, TNFRSF11B, BGLAP
2extracellular spaceGO:00056158.2FGF23, PTH, TNFRSF11B, BGLAP

Biological processes related to Renal Osteodystrophy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:00332809.7PTH, BGLAP
2response to ethanolGO:00454719.6PTH, BGLAP
3bone resorptionGO:00454539.3ACP5, PTH
4response to estrogenGO:00436279.3TNFRSF11B, BGLAP
5cellular calcium ion homeostasisGO:00068749.2CASR, PTH
6skeletal system developmentGO:00015019.1PTH, TNFRSF11B, BGLAP
7response to drugGO:00424939.0BGLAP, TNFRSF11B, PTH

Products for genes affiliated with Renal Osteodystrophy

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Sources for Renal Osteodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet