MCID: RNL011
MIFTS: 51

Renal Osteodystrophy malady

Rare diseases, Nephrological diseases, Bone diseases categories

Summaries for Renal Osteodystrophy

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Wikipedia:64 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards based summary: Renal Osteodystrophy, also known as renal rickets, is related to osteonecrosis and hyperostosis. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and FGF signaling pathway. The compounds pyridinoline and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Renal Osteodystrophy

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Renal Osteodystrophy, Aliases & Descriptions:

Name: Renal Osteodystrophy 9 11 44 61
Renal Rickets 9 42 61
 
Renal Osteodystrophy Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Bone diseases


External Ids:

Disease Ontology9 DOID:13068
MeSH34 D012080
ICD9CM28 588.0
ICD1026 N25.0

Related Diseases for Renal Osteodystrophy

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Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1osteonecrosis31.2BGLAP
2hyperostosis30.7BGLAP, FGF23
3osteosclerosis30.6PTH, TNFRSF11B
4uremia30.6TNFRSF11B, PTH, CASR
5osteitis fibrosa30.6BGLAP, PTH, CASR
6pseudohypoparathyroidism30.5PTH, BGLAP
7metabolic acidosis30.4PTH, BGLAP
8rickets30.4CASR, PTH, BGLAP
9calcinosis30.1PTH, CASR, FGF23
10arthritis30.0ACP5, TNFRSF11B, BGLAP
11osteomalacia30.0BGLAP, TNFRSF11B, PTH, CASR, FGF23
12hyperparathyroidism29.9FGF23, CASR, ACP5, PTH, TNFRSF11B, BGLAP
13hypercalcemia29.8BGLAP, TNFRSF11B, PTH, CASR, FGF23
14primary hyperparathyroidism29.3BGLAP, PTH, ACP5, CASR, FGF23
15chronic kidney failure28.9BGLAP, TNFRSF11B, PTH, ACP5, CASR, FGF23
16peritonitis10.7
17kidney disease10.5
18camurati-engelmann disease10.4BGLAP
19hypervitaminosis d10.4FGF23
20cervicitis10.4
21synovitis10.4TNFRSF11B
22spinal stenosis10.3
23slipped capital femoral epiphysis10.3
24pseudohypoparathyroidism type 1b10.3BGLAP, PTH
25parathyroid carcinoma10.2PTH, CASR
26end stage renal failure10.2
27hypophosphatasia10.2
28goiter10.2PTH, BGLAP
29x-linked hypophosphatemia10.2FGF23, PTH
30parathyroid adenoma10.2PTH, CASR
31wermer syndrome10.2CASR, PTH
32fibrous dysplasia10.2BGLAP, FGF23
33primary hyperoxaluria10.2PTH, BGLAP
34osteopetrosis10.1TNFRSF11B, BGLAP
35bone cancer10.1TNFRSF11B, BGLAP
36rheumatic disease10.1BGLAP, TNFRSF11B
37cushing's syndrome10.1BGLAP, TNFRSF11B
38arthropathy10.1FGF23, TNFRSF11B
39avascular necrosis of the femoral head10.1
40bone fracture10.1
41hypertension10.1
42myelofibrosis10.1
43blount's disease10.1
44fanconi syndrome10.1
45polycystic kidney disease10.1
46achondroplasia10.1
47psoriatic arthritis10.1
48brachydactyly10.1
49pancytopenia10.1
50cranial nerve palsy10.1

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Symptoms for Renal Osteodystrophy

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Drugs & Therapeutics for Renal Osteodystrophy

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Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

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Anatomical Context for Renal Osteodystrophy

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MalaCards organs/tissues related to Renal Osteodystrophy:

32
Bone, Kidney, Bone marrow, Cortex, Spinal cord, Testes

Animal Models for Renal Osteodystrophy or affiliated genes

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MGI Mouse Phenotypes related to Renal Osteodystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFRSF11B, PTH, ACP5, FGF23
2MP:00053907.6FGF23, CASR, ACP5, PTH, TNFRSF11B
3MP:00053877.6FGF23, CASR, ACP5, PTH, TNFRSF11B
4MP:00053977.3TNFRSF11B, PTH, ACP5, CASR, FGF23

Publications for Renal Osteodystrophy

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Articles related to Renal Osteodystrophy:

(show top 50)    (show all 507)
idTitleAuthorsYear
1
Severe renal osteodystrophy in a pediatric patient with end-stage renal disease: Sagliker syndrome? (23026501)
2013
2
The influence of medical and nonmedical factors to the progression of renal osteodystrophy. (20102101)
2009
3
Chronic pachymeningitis and bilateral facial paralysis secondary to renal osteodystrophy. (18347262)
2008
4
Clinical and economic burden of fractures in patients with renal osteodystrophy. (17474555)
2007
5
Renal osteodystrophy, phosphate homeostasis, and vascular calcification. (17635820)
2007
6
Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients. (15665550)
2005
7
Utilization of bone histomorphometry in renal osteodystrophy: demonstration of a new approach using data from a prospective study of lanthanum carbonate. (15730056)
2005
8
Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease. (15882311)
2005
9
Localized jaw enlargement in renal osteodystrophy: report of a case and review of the literature. (14716259)
2004
10
New aspects in the management of renal osteodystrophy]. (15669206)
2004
11
Radiologic features of renal osteodystrophy in a patient with "normal" bone mineralization. (12970649)
2003
12
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
13
Renal osteodystrophy. (12041521)
2002
14
Adynamic renal osteodystrophy: is there a problem? (11518793)
2001
15
Management of secondary hyperparathyroidism: the gap between diagnosis and treatment. The Renal Osteodystrophy Multicenter Enquiry. (10981485)
2000
16
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
17
High frequency of iron bone deposits in a Mexican population with renal osteodystrophy. (9568820)
1998
18
Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy: what do we have, what do we need? (9568817)
1998
19
Magnetic resonance imaging of renal osteodystrophy in children. (9361047)
1997
20
Myelofibrosis secondary to renal osteodystrophy. (8730443)
1996
21
Secondary hyperparathyroidism and renal osteodystrophy. (7728664)
1995
22
Detection of subtle aluminum-related renal osteodystrophy. (7683072)
1993
23
Renal osteodystrophy in diabetic patients. (8355457)
1993
24
Comparison of renal osteodystrophy in patients undergoing continuous ambulatory peritoneal dialysis and hemodialysis. (8399637)
1993
25
Renal osteodystrophy and hypercalcemia. (8512774)
1993
26
PTH and bone markers of renal osteodystrophy in predialysis chronic renal failure. (1300330)
1992
27
Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. (1453606)
1992
28
The radiographic spectrum of renal osteodystrophy. (1986484)
1991
29
Prevention of renal osteodystrophy. (1813786)
1991
30
Diagnostic evaluation of plasma free gamma-carboxyglutamic acid in maintenance hemodialytic patients with renal osteodystrophy]. (2082053)
1990
31
Use of oral and parenteral calcitriol in the treatment of renal osteodystrophy. (2214548)
1990
32
Is renal osteodystrophy rare in the tropics? (2362644)
1990
33
Efficacy of calcium carbonate and low-dose vitamin D/1,25(OH)2D3 in reducing the risk of developing renal osteodystrophy in children on continuous ambulatory peritoneal dialysis. (2088463)
1990
34
Diagnosis of renal osteodystrophy with the Jamshidi needle biopsy. (2750179)
1989
35
51Cr-EDTA/99Tcm-MDP ratio: a simple non-invasive method for assessing renal osteodystrophy. (2496884)
1989
36
1,25 (OH)2 vitamin D3 deficiency and renal osteodystrophy: should its well-accepted pathogenetic role in secondary hyperparathyroidism lead to its systematic preventive therapeutic use? (3126450)
1987
37
Primary bone oxalosis: the roles of oxalate deposits and renal osteodystrophy. (3593609)
1987
38
Behavior of the vitamin D endocrine system in the development of renal osteodystrophy. (3299575)
1986
39
Renal osteodystrophy in asymptomatic hemodialysis patients: evidence of a sex-dependent distribution and predictive value of serum aluminum measurements. (3812472)
1986
40
The effect of hemodialysis, vitamin D metabolites and renal transplantation on the skeletal demineralization associated with renal osteodystrophy: a computerized histomorphometric analysis. (3542321)
1986
41
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
42
Total parathyroidectomy and parathyroid autograft for renal osteodystrophy: analysis of the cause of failure. (4013363)
1985
43
Observations on computerized quantitative bone scintigraphy in renal osteodystrophy. (6437823)
1984
44
Consequences of avascular necrosis of the femoral head in aluminium-related renal osteodystrophy and the role of endochondral ossification in the repair process. (6402524)
1983
45
Caring for patients with renal osteodystrophy. (6552189)
1983
46
Bone aluminum deposition in renal osteodystrophy. (6185842)
1983
47
Therapeutic effects of 25-hydroxycholecalciferol and sodium etidronate on renal osteodystrophy. (6820473)
1982
48
Renal osteodystrophy in children with chronic renal failure: an unexpectedly common and incapactating complication. (6982452)
1982
49
Radiographic interpretation of the mandibular angular cortex: a diagnostic tool in metabolic bone loss. Part II. Renal osteodystrophy. (6954448)
1982
50
Renal osteodystrophy presenting as periurethral abscess. (7147513)
1982

Variations for Renal Osteodystrophy

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Expression for genes affiliated with Renal Osteodystrophy

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Expression patterns in normal tissues for genes affiliated with Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

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Pathways related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BGLAP, PTH
29.5FGF23, BGLAP
39.0ACP5, TNFRSF11B
49.0ACP5, TNFRSF11B
5
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling59
9.0ACP5, TNFRSF11B
69.0PTH, TNFRSF11B, BGLAP
78.9FGF23, PTH, TNFRSF11B

Compounds for genes affiliated with Renal Osteodystrophy

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Compounds related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1pyridinoline4410.3TNFRSF11B
2calcium carbonate449.9PTH, BGLAP
322-oxacalcitriol449.9BGLAP, CASR
4deflazacort449.8TNFRSF11B, BGLAP
5teriparatide44 1210.8BGLAP, TNFRSF11B
6thiazide449.8CASR, BGLAP
7etidronate449.8TNFRSF11B, BGLAP
8ibandronate44 1210.7BGLAP, TNFRSF11B
9strontium449.7TNFRSF11B, CASR
10vitamin k2449.7TNFRSF11B, BGLAP
11risedronate44 50 29 60 1213.7TNFRSF11B, BGLAP
12hydrochlorothiazide44 29 50 25 1213.6CASR, BGLAP
13zoledronic acid449.5TNFRSF11B, BGLAP
14tartrate449.5BGLAP, ACP5
15tibolone449.4BGLAP, ACP5
16sevelamer449.4BGLAP, FGF23, CASR
17ns 39844 6010.4TNFRSF11B, BGLAP
18infliximab44 50 1211.4TNFRSF11B, BGLAP
19alendronate44 50 1211.4PTH, BGLAP, TNFRSF11B
20thyroxine44 2510.3TNFRSF11B, PTH, BGLAP
21pmma449.2ACP5, TNFRSF11B
22tamoxifen44 50 29 1212.2TNFRSF11B, PTH, BGLAP
23raloxifene44 50 29 1212.1TNFRSF11B, BGLAP
24clodronate44 50 1211.0TNFRSF11B, ACP5, BGLAP
25forskolin44 50 1211.0TNFRSF11B, PTH, CASR
26titanium449.0BGLAP, TNFRSF11B, ACP5
27azathioprine44 3 50 1212.0BGLAP, TNFRSF11B, ACP5
28pamidronate44 50 1210.9BGLAP, PTH, CASR, TNFRSF11B
29arginine448.9CASR, FGF23, BGLAP, PTH
30sodium44 259.8CASR, PTH, TNFRSF11B
31deoxypyridinoline448.6PTH, ACP5, TNFRSF11B, BGLAP
32hydroxyproline44 25 1210.6ACP5, PTH, TNFRSF11B, BGLAP
33procollagen448.6ACP5, TNFRSF11B, PTH, BGLAP
34estradiol44 25 1210.6PTH, ACP5, TNFRSF11B, BGLAP
35dexamethasone44 50 29 1211.5ACP5, TNFRSF11B, PTH, BGLAP
36cyclosporin a44 29 6010.4CASR, TNFRSF11B, ACP5, BGLAP
37heparin44 29 25 1211.4TNFRSF11B, FGF23, BGLAP, ACP5
38nitric oxide44 25 1210.4CASR, TNFRSF11B, PTH, ACP5
39cysteine448.3BGLAP, TNFRSF11B, ACP5, CASR
40pge2448.1TNFRSF11B, BGLAP, CASR, PTH, ACP5
41estrogen448.0BGLAP, TNFRSF11B, CASR, PTH, ACP5
42hydroxyapatite448.0TNFRSF11B, BGLAP, ACP5, CASR, FGF23
43tyrosine447.9TNFRSF11B, FGF23, PTH, ACP5, CASR
4425-hydroxyvitamin d447.6CASR, FGF23, ACP5, PTH, BGLAP, TNFRSF11B
45phosphorus447.6FGF23, CASR, ACP5, PTH, TNFRSF11B, BGLAP
461,25 dihydroxy vitamin d3447.6FGF23, ACP5, PTH, TNFRSF11B, BGLAP, CASR
47calcitriol44 60 25 1210.6BGLAP, ACP5, TNFRSF11B, FGF23, PTH, CASR
48vitamin d447.6PTH, TNFRSF11B, ACP5, CASR, FGF23, BGLAP
49creatinine447.6FGF23, BGLAP, CASR, TNFRSF11B, PTH, ACP5
50calcium44 50 25 1210.5FGF23, PTH, BGLAP, CASR, ACP5, TNFRSF11B

GO Terms for genes affiliated with Renal Osteodystrophy

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Cellular components related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5FGF23, PTH, TNFRSF11B, BGLAP
2extracellular spaceGO:0056158.2FGF23, PTH, TNFRSF11B, BGLAP

Biological processes related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:0332809.7PTH, BGLAP
2response to ethanolGO:0454719.6PTH, BGLAP
3bone resorptionGO:0454539.3ACP5, PTH
4response to estrogenGO:0436279.3TNFRSF11B, BGLAP
5cellular calcium ion homeostasisGO:0068749.2CASR, PTH
6skeletal system developmentGO:0015019.1PTH, TNFRSF11B, BGLAP
7response to drugGO:0424939.0BGLAP, TNFRSF11B, PTH

Products for genes affiliated with Renal Osteodystrophy

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Sources for Renal Osteodystrophy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet