MCID: RNL011
MIFTS: 56

Renal Osteodystrophy malady

Nephrological diseases, Bone diseases categories

Summaries for Renal Osteodystrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards: Renal Osteodystrophy, also known as renal rickets, is related to peritonitis and hyperparathyroidism. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Renal Osteodystrophy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Bone diseases


Aliases & Descriptions:

renal osteodystrophy 8 10 44 60
renal rickets 8 42 60
renal osteodystrophy nos 8


External Ids:

Disease Ontology8 DOID:13068
ICD9CM27 588.0
MeSH34 D012080
ICD1025 N25.0

Related Diseases for Renal Osteodystrophy

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17GeneCards, 18GeneDecks
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Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.0SLPI
2hyperparathyroidism31.0BGLAP, CALCA, CASR, TNFRSF11B, IGFBP4, VDR
3uremia30.5CASR, TNFRSF11B, IGFBP1, VDR, PTH
4osteomalacia30.5PTH, SLPI, FGF23, CD36, BGLAP, CALCA
5osteonecrosis30.4BGLAP
6osteitis fibrosa30.4PTH, CASR, BGLAP
7spinal stenosis30.4BMP7, CALCA
8hypercalcemia30.4BGLAP, CALCA, CASR, TNFRSF11B, MGP, VDR
9hyperostosis30.2FGF23, SOST, BGLAP
10osteosclerosis30.2PTH, TNFRSF11B, SOST
11rickets30.2PTH, CD36, VDR, CASR, BGLAP
12hypertension30.0CALCA, PTH
13metabolic acidosis30.0PTH, BGLAP
14calcinosis30.0PTH, FGF23, CASR
15pseudohypoparathyroidism30.0PTH, CALCA, BGLAP
16arthritis30.0BGLAP, CALCA, TNFRSF11B, BMP7, VDR, ACP5
17primary hyperparathyroidism30.0VDR, CD36, FGF23, ACP5, PTH, IGFBP1
18chronic kidney failure30.0BGLAP, CASR, TNFRSF11B, BMP7, IGFBP1, IGFBP4
19kidney disease10.5
20cervicitis10.3
21bone fracture10.3
22end stage renal failure10.2
23hypophosphatasia10.2
24renal vascular disease10.2
25vascular disease10.2
26blount's disease10.0
27achondroplasia10.0
28psoriatic arthritis10.0
29brachydactyly10.0
30pancytopenia10.0
31fanconi syndrome10.0
32polycystic kidney disease10.0
33adult syndrome10.0
34cranial nerve palsy10.0
35facial paralysis10.0
36lupus erythematosus10.0
37myelofibrosis10.0
38neuropathy10.0
39periostitis10.0
40renal hypertension10.0
41vitamin metabolic disorder10.0
42pancreatitis10.0CASR
43obesity10.0IGFBP1
44prostatitis10.0VDR
45thyroiditis10.0CALCA
46gingivitis10.0TNFRSF11B
47insulin resistance10.0IGFBP1
48hepatitis10.0IGFBP1
49liver cirrhosis10.0SLPI
50hypervitaminosis d10.0FGF23

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Clinical Features for Renal Osteodystrophy

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Drugs & Therapeutics for Renal Osteodystrophy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renal Osteodystrophy

Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Search CenterWatch for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

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Anatomical Context for Renal Osteodystrophy

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32MalaCards
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MalaCards organs/tissues related to Renal Osteodystrophy:

32
Bone, Kidney, Bone marrow, Cortex, Spinal cord, Testes

Animal Models for Renal Osteodystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Osteodystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1SOST, DKK1, FGF23, ACP5
2MP:00053799.9VDR, IGFBP5, IGFBP4, BMP7
3MP:00053679.9CASR, BMP7, MGP, DKK1, FGF23
4MP:00053909.7ACP5, FGF23, CD36, DKK1, MGP, BMP7
5MP:00053879.2CASR, TNFRSF11B, BMP7, IGFBP1, VDR, CD36
6MP:00053859.1CALCA, TNFRSF11B, BMP7, MGP, VDR, CD36
7MP:00053789.1CASR, SOST, TNFRSF11B, BMP7, MGP, IGFBP4
8MP:00053768.9IGFBP4, SOST, CASR, CALCA, IGFBP5, DKK1
9MP:00107688.9MGP, BMP7, TNFRSF11B, CASR, CALCA, DKK1

Publications for Renal Osteodystrophy

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50PubMed
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Articles related to Renal Osteodystrophy:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Renal osteodystrophy: neurosurgical considerations and challenges. (22120255)
2012
2
Vascular calcifications and renal osteodystrophy in chronic hemodialysis patients: what is the relationship between them? (20862543)
2011
3
Sclerostin and Dickkopf-1 in renal osteodystrophy. (21164019)
2011
4
Correction of lower limb deformities in children with renal osteodystrophy by the Ilizarov method. (18812901)
2008
5
Macrognathia secondary to dialysis-related renal osteodystrophy treated successfully by parathyroidectomy. (16360304)
2006
6
Renal osteodystrophy: a pediatric perspective, 2005. (16039889)
2005
7
Special aspects of renal osteodystrophy in children. (14730512)
2004
8
Treatment of a murine model of high-turnover renal osteodystrophy by exogenous BMP-7. (11918739)
2002
9
Strontium overload and toxicity: impact on renal osteodystrophy. (11904356)
2002
10
Renal osteodystrophy in developing countries. (12197931)
2002
11
Bisphosphonates in renal osteodystrophy. (11496050)
2001
12
Regulation of bone cell development and function: implication for renal osteodystrophy. (11352181)
2001
13
Calcitriol, lanthanum carbonate, and other new phosphate binders in the management of renal osteodystrophy. (10406555)
1999
14
New insights related to aging and renal osteodystrophy. (10435227)
1999
15
Renal osteodystrophy in pre-dialysis patients: ethnic difference? (10406554)
1999
16
Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy: what do we have, what do we need? (9568817)
1998
17
Renal osteodystrophy. (9608898)
1998
18
Prevention, diagnosis and treatment of renal osteodystrophy in Spain. Preliminary results from a multicentre enquiry. (9568821)
1998
19
Microfocal radiography in the diagnosis of childhood renal osteodystrophy. (9821707)
1998
20
Is severe renal osteodystrophy a contraindication for recombinant human growth hormone treatment? (8792404)
1996
21
Secondary hyperparathyroidism and renal osteodystrophy. (7728664)
1995
22
Diagnostic value of serum peptides of collagen synthesis and degradation in dialysis renal osteodystrophy. (7724029)
1995
23
Renal osteodystrophy. (7791820)
1995
24
Dietary and pharmacotherapeutic considerations in the management of renal osteodystrophy. (7614336)
1995
25
Renal osteodystrophy and dialysis artifacts as indicators of identification. (8206460)
1994
26
Use of skeletal surveys in the radiological assessment of renal osteodystrophy--a study in the Singapore General Hospital. (8267351)
1993
27
Case report 772. Stress fracture of the hip secondary to renal osteodystrophy and erosion of ischium due to amyloid deposition. (8438184)
1993
28
Hereditary polycystic kidney disease. Adult polycystic kidney disease associated with renal hypertension, renal osteodystrophy, and uremic enteritis in SPRD rats. (1887867)
1991
29
Renal osteodystrophy. (1649677)
1991
30
Is renal osteodystrophy rare in the tropics? (2362644)
1990
31
Renal osteodystrophy. (2192869)
1990
32
Growth plate injury of the hand and wrist in renal osteodystrophy. (2255949)
1990
33
Quantitative computed tomographic evaluation of femoral bone mineral content in renal osteodystrophy compared with radial photon absorptiometry. (2745019)
1989
34
Brown tumor of the tibia as an early manifestation of renal osteodystrophy. A case report. (3370881)
1988
35
Primary bone oxalosis: the roles of oxalate deposits and renal osteodystrophy. (3593609)
1987
36
Pathologic fractures in a patient with renal osteodystrophy. Failure of early detection on bone scans. (3608330)
1987
37
Osteosclerosis in a skunk with renal fibrous osteodystrophy. (3505965)
1986
38
Spinal bone measurement in renal osteodystrophy. (4058631)
1985
39
Nutrition and renal osteodystrophy. (3837819)
1985
40
Treatment of renal osteodystrophy in children with dihydrotachysterol and 24,25-dihydroxyvitamin D3. (3878249)
1985
41
Renal osteodystrophy in CAPD patients. (6493161)
1984
42
Consequences of avascular necrosis of the femoral head in aluminium-related renal osteodystrophy and the role of endochondral ossification in the repair process. (6402524)
1983
43
Linear decline in serum alkaline phosphatase activity during treatment of renal osteodystrophy. (6401474)
1983
44
Treatment of renal osteodystrophy with Dialume recipes. (6558057)
1983
45
Growth retardation and renal osteodystrophy in children with chronic renal failure. (6631600)
1983
46
Therapeutic effects of 25-hydroxycholecalciferol and sodium etidronate on renal osteodystrophy. (6820473)
1982
47
Radiographic interpretation of the mandibular angular cortex: a diagnostic tool in metabolic bone loss. Part II. Renal osteodystrophy. (6954448)
1982
48
Bone aluminum and histomorphometric features of renal osteodystrophy. (7056841)
1982
49
Renal osteodystrophy: magnification radiography of target sites of absorption. (6784465)
1981
50
Metabolic studies of renal osteodystrophy. I. Calcium, phosphorus and nitrogen metabolism in rickets, osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult Fanconi syndrome. (13916186)
1962

Genetic Variations for Renal Osteodystrophy

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Expression for genes affiliated with Renal Osteodystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological, 53Reactome
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Pathways related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ACP5, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
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10.2PTH, VDR
310.1TNFRSF11B, FGF23, PTH
410.1BMP7, MGP, PTH
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.1PTH, VDR, BGLAP
6
Hide members
9.9DKK1, IGFBP4, SOST
79.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
89.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8PTH, VDR, TNFRSF11B, CALCA, BGLAP
10
Hide members
9.7IGFBP5, IGFBP6, IGFBP4, IGFBP1, CALCA

Compounds for genes affiliated with Renal Osteodystrophy

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1procollagen4410.8ACP5
2estrogen4410.6MGP, VDR
3cycloheximide4410.6IGFBP1, PTH
422-oxacalcitriol4410.2BGLAP, VDR, CASR, CD36
5teriparatide44 1111.2BGLAP, CALCA, TNFRSF11B, CD36
6ibandronate44 1111.2BGLAP, TNFRSF11B, CD36, CALCA
7alfacalcidol44 59 1112.2BGLAP, CALCA, VDR, SLPI
8calcium carbonate4410.2CD36, BGLAP, PTH, CALCA
9etidronate4410.1CALCA, TNFRSF11B, CD36, SLPI, BGLAP
10sevelamer4410.1BGLAP, CASR, FGF23
11vitamin k24410.1SLPI, CD36, CALCA, BGLAP, TNFRSF11B
12ipriflavone4410.1CALCA, SLPI, BGLAP
13tartrate4410.1BGLAP, CALCA, CD36, SLPI, ACP5
14pamidronate44 49 1112.1CASR, TNFRSF11B, CD36, BGLAP, CALCA, PTH
15risedronate44 59 49 28 1114.1SLPI, CD36, TNFRSF11B, CALCA, BGLAP
16clodronate44 49 1112.1VDR, TNFRSF11B, CALCA, ACP5, SLPI, CD36
17zoledronic acid4410.1CALCA, SLPI, CD36, TNFRSF11B, BGLAP
18thiazide4410.1VDR, CALCA, BGLAP, CASR
19estradiol44 11 2412.1SLPI, ACP5, IGFBP6, IGFBP4, IGFBP5
20forskolin44 49 1112.0CALCA, IGFBP5, IGFBP4, PTH, IGFBP6
21titanium4410.0BGLAP, BMP7, SLPI, TNFRSF11B, CD36, ACP5
22denosumab44 1111.0TNFRSF11B, SOST, CALCA
23raloxifene44 28 49 1113.0SLPI, CD36, TNFRSF11B, CALCA, BGLAP, VDR
24pyridinoline449.9BGLAP, CALCA, TNFRSF11B, CD36, SIL1, SLPI
25alendronate44 49 1111.9CD36, PTH, SLPI, VDR, TNFRSF11B, CALCA
26hydrocortisone44 2 59 1112.9CALCA, SLPI, CD36, IGFBP1, TNFRSF11B, BGLAP
27hydroxyproline44 11 2411.8PTH, ACP5, SLPI, BGLAP, CALCA, CD36
28gold449.8IGFBP4, IGFBP5, BMP7, TNFRSF11B, IGFBP1
29thyroxine44 2410.8IGFBP4, VDR, IGFBP5, IGFBP1, PTH, TNFRSF11B
30dexamethasone44 49 28 1112.8VDR, BGLAP, SLPI, ACP5, IGFBP4, BMP7
31phosphorus449.7CALCA, CASR, TNFRSF11B, VDR, FGF23, SLPI
32ribonucleic acid449.7IGFBP4, BMP7, IGFBP1, CASR, IGFBP5, PTH
33serine449.6MGP, IGFBP4, TNFRSF11B, VDR, BMP7, CASR
341,25 dihydroxy vitamin d3449.6PTH, ACP5, FGF23, IGFBP5, IGFBP4, TNFRSF11B
35hydroxyapatite449.5TNFRSF11B, BMP7, MGP, BGLAP, CASR, IGFBP5
36tamoxifen44 49 28 1112.5PTH, SLPI, VDR, IGFBP5, IGFBP1, TNFRSF11B
37deoxypyridinoline449.5PTH, ACP5, SLPI, SIL1, CD36, VDR
38cyclosporin a44 28 5911.5CALCA, CASR, TNFRSF11B, VDR, SLPI, ACP5
39cysteine449.5CASR, SLPI, VDR, CD36, IGFBP4, IGFBP1
40testosterone44 59 11 2412.5SLPI, TNFRSF11B, PTH, BGLAP, VDR, CALCA
41thymidine44 2410.5IGFBP6, IGFBP5, IGFBP1, VDR, SLPI, BMP7
42vegf449.4IGFBP1, BMP7, TNFRSF11B, BGLAP, CALCA, IGFBP4
43heparin44 28 11 2412.4IGFBP4, CD36, BMP7, IGFBP5, IGFBP6, FGF23
44creatinine449.3BMP7, TNFRSF11B, CASR, BGLAP, IGFBP1, IGFBP5
45ascorbic acid44 2410.3VDR, TNFRSF11B, BGLAP, CD36, BMP7, SLPI
4625-hydroxyvitamin d449.3BGLAP, CALCA, CASR, TNFRSF11B, IGFBP4, IGFBP5
47retinoic acid44 2410.2TNFRSF11B, BMP7, MGP, BGLAP, SLPI, VDR
48calcitriol44 59 11 2412.1BGLAP, CALCA, IGFBP1, IGFBP5, VDR, CD36
49vitamin d448.9BGLAP, CALCA, CASR, SOST, TNFRSF11B, BMP7
50calcium44 49 11 2411.5PTH, SLPI, FGF23, CD36, VDR, CALCA

GO Terms for genes affiliated with Renal Osteodystrophy

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16Gene Ontology
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Cellular components related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8BMP7, TNFRSF11B, FETUB, CALCA, IGFBP1, IGFBP4
2extracellular spaceGO:0056158.3PTH, BGLAP, CALCA, SOST, FETUB, TNFRSF11B

Biological processes related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.5VDR, FGF23
2regulation of removal of superoxide radicalsGO:200012110.4CD36, BMP7
3negative regulation of bone resorptionGO:04577910.4CALCA, TNFRSF11B
4type B pancreatic cell proliferationGO:04434210.4IGFBP5, IGFBP4
5cellular calcium ion homeostasisGO:00687410.3PTH, VDR, CASR
6negative regulation of protein complex assemblyGO:03133310.2DKK1, SOST
7regulation of cell growthGO:00155810.2IGFBP5, IGFBP6, IGFBP4
8ossificationGO:00150310.2MGP, BMP7, SOST, CASR
9regulation of glucose metabolic processGO:01090610.2IGFBP5, IGFBP4
10regulation of bone mineralizationGO:03050010.1MGP, BGLAP
11positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGFBP4, IGFBP5
12skeletal system developmentGO:0015019.9PTH, BGLAP, TNFRSF11B, BMP7, IGFBP4, VDR
13negative regulation of ossificationGO:0302799.9SOST, CALCA
14signal transductionGO:0071659.7TNFRSF11B, IGFBP1, IGFBP4, IGFBP6, IGFBP5, VDR

Molecular functions related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor I bindingGO:03199410.2IGFBP5, IGFBP6
2structural constituent of boneGO:0081479.8MGP, BGLAP

Products for genes affiliated with Renal Osteodystrophy

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  • Antibodies
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Sources for Renal Osteodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet