MCID: RNL011
MIFTS: 50

Renal Osteodystrophy malady

Nephrological, Bone categories

Summaries for Renal Osteodystrophy

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards: Renal Osteodystrophy, also known as renal rickets, is related to uremia and osteomalacia. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Renal Osteodystrophy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 43NIH Rare Diseases, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Bone


Aliases & Descriptions:

renal osteodystrophy 8 10 45 61
renal rickets 8 43 61
renal osteodystrophy nos 8


External Ids:

Disease Ontology8 DOID:13068
ICD9CM27 588.0
MeSH35 D012080
ICD1025 N25.0

Related Diseases for Renal Osteodystrophy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 124)
idRelated DiseaseScoreTop Affiliating Genes
1uremia30.6CASR, TNFRSF11B, IGFBP1, VDR, PTH
2osteomalacia30.6PTH, SLPI, FGF23, CD36, BGLAP, CALCA
3osteonecrosis30.4BGLAP
4osteitis fibrosa30.4PTH, CASR, BGLAP
5spinal stenosis30.4BMP7, CALCA
6hypercalcemia30.4BGLAP, CALCA, CASR, TNFRSF11B, MGP, VDR
7rickets30.3PTH, CD36, VDR, CASR, BGLAP
8metabolic acidosis30.0PTH, BGLAP
9arthritis30.0BGLAP, CALCA, TNFRSF11B, BMP7, VDR, ACP5
10primary hyperparathyroidism30.0VDR, CD36, FGF23, ACP5, PTH, IGFBP1
11bone fracture10.3
12slipped capital femoral epiphysis10.3
13hypophosphatasia10.2
14vascular disease10.2
15achondroplasia10.0
16psoriatic arthritis10.0
17brachydactyly10.0
18pancytopenia10.0
19fanconi syndrome10.0
20polycystic kidney disease10.0
21adult syndrome10.0
22n syndrome10.0
23nutrition disease10.0
24sagliker syndrome10.0
25peritonitis10.0SLPI
26pancreatitis10.0CASR
27obesity10.0IGFBP1
28prostatitis10.0VDR
29thyroiditis10.0CALCA
30gingivitis10.0TNFRSF11B
31insulin resistance10.0IGFBP1
32hepatitis10.0IGFBP1
33liver cirrhosis10.0SLPI
34hypervitaminosis d10.0FGF23
35dwarfism10.0
36toni-fanconi syndrome10.0
37epidermal nevus10.0
38asthma10.0VDR
39root resorption10.0TNFRSF11B
40coronary heart disease10.0MGP
41hypogonadism10.0BGLAP, CALCA
42polycystic ovary syndrome10.0IGFBP4, IGFBP1
43hypertension10.0CALCA, PTH
44anorexia nervosa10.0IGFBP1, TNFRSF11B
45fibrous dysplasia10.0FGF23, BGLAP
46sarcoma10.0SLPI, VDR
47cystic fibrosis10.0SLPI, TNFRSF11B
48growth hormone deficiency10.0BGLAP, IGFBP1
49osteopetrosis10.0TNFRSF11B, BGLAP
50multiple myeloma10.0DKK1, TNFRSF11B

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Clinical Features for Renal Osteodystrophy

Drugs & Therapeutics for Renal Osteodystrophy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Renal Osteodystrophy

Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Search CenterWatch for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

Anatomical Context for Renal Osteodystrophy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Renal Osteodystrophy:

33
Spinal cord, Kidney, Bone marrow, Cortex

Animal Models for Renal Osteodystrophy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Renal Osteodystrophy

Sources:
51PubMed
See all sources

Articles related to Renal Osteodystrophy:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
A case of renal osteodystrophy with unexpected serum intact parathyroid hormone concentrations. (19717659)
2009
2
Chronic pachymeningitis and bilateral facial paralysis secondary to renal osteodystrophy. (18347262)
2008
3
Images in clinical medicine. Renal osteodystrophy of the palate. (18596275)
2008
4
Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients. (15665550)
2005
5
Biochemical indices of renal osteodystrophy in dialysis patients on the island of Malta. (16142567)
2005
6
New PTH assays and renal osteodystrophy. (15173936)
2004
7
Management of renal osteodystrophy in peritoneal dialysis patients. (15185768)
2004
8
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
9
Serum osteoprotegerin and renal osteodystrophy. (11812872)
2002
10
Prevention and treatment of renal osteodystrophy in children with chronic renal insufficiency and end-stage renal disease. (11559885)
2001
11
The role of imaging techniques in the study of renal osteodystrophy. (10981482)
2000
12
Prevention of renal osteodystrophy in predialysis patients. (10372840)
1999
13
Epidemiology of renal osteodystrophy in Iberoamerica. (9568819)
1998
14
Bone scan appearance of renal osteodystrophy in diabetic chronic renal failure patients. (9929141)
1998
15
Bone marrow immunoscintigraphy (BMIS): a new and important tool for the assessment of marrow fibrosis in renal osteodystrophy? (10649720)
1998
16
Renal osteodystrophy in dialysis patients: diagnosis and treatment. (9684690)
1998
17
Pentavalent technetium-99m-dimercaptosuccinic acid scintigraphy in renal osteodystrophy. (9529307)
1998
18
Surgical correction of angular deformity of the knee in children with renal osteodystrophy. (8989700)
1997
19
Renal osteodystrophy. (9222491)
1997
20
The role of metabolic acidosis in the pathogenesis of renal osteodystrophy. (7614335)
1995
21
Vitamin D3 analogs and salmon calcitonin partially reverse the development of renal osteodystrophy in rats. (8564802)
1995
22
Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD/CCPD. (8127016)
1994
23
Oxalosis associated with aluminum bone disease: a new type of mixed renal osteodystrophy. (8107962)
1994
24
Renal osteodystrophy in diabetic patients. (8355457)
1993
25
Maxillary brown tumor as manifestation of renal osteodystrophy. (8341400)
1993
26
Technological testing of calcium carbonate tablets for use in the treatment of renal osteodystrophy. (8397681)
1993
27
Renal osteodystrophy: pathophysiology. (1561500)
1992
28
Renal osteodystrophy with multiple osteolytic lesions in the skull. (1294495)
1992
29
Assessment of renal osteodystrophy in hemodialysis patients. (1522804)
1992
30
Marked improvement in parameters of renal osteodystrophy with the use of intraperitoneal calcitriol. (1361854)
1992
31
Angular deformity of the lower extremity in children with renal osteodystrophy. (1572991)
1992
32
Renal osteodystrophy. (1478326)
1992
33
Aluminum: effects on bone and role in the pathogenesis of renal osteodystrophy. (1813784)
1991
34
No effect of APD (amino hydroxypropylidene bisphosphonate) on hypercalcemia in patients with renal osteodystrophy. (2331426)
1990
35
Musculoskeletal case of the day. Primary oxalosis with renal osteodystrophy. (2110756)
1990
36
Renal osteodystrophy: an update on pathogenesis and treatment. (2674738)
1989
37
Influence of keto acid (KA) treatment on renal osteodystrophy. (3501767)
1987
38
The wide spectrum of renal osteodystrophy in children. (3322679)
1987
39
Recent advances and controversies in childhood renal osteodystrophy. (3153280)
1987
40
Comparison of parathyroid hormone assays with bone histomorphometry in renal osteodystrophy. (3760116)
1986
41
Aluminum and renal osteodystrophy in chronic uremia. (3867793)
1985
42
Renal osteodystrophy and metastatic calcification in long-term continuous ambulatory peritoneal dialysis. (3975345)
1985
43
Fluoride metabolism and renal osteodystrophy in regular dialysis treatment. (3991535)
1985
44
Observations on computerized quantitative bone scintigraphy in renal osteodystrophy. (6437823)
1984
45
Histological renal osteodystrophy, and 25 hydroxycholecalciferol and aluminum levels in patients on continuous ambulatory peritoneal dialysis. (6834691)
1983
46
Renal osteodystrophy in children with chronic renal failure: an unexpectedly common and incapactating complication. (6982452)
1982
47
Localisation of aluminium by histochemical and electron probe x-ray microanalytical techniques in bone tissue of cases of renal osteodystrophy. (7142436)
1982
48
Evolution of renal osteodystrophy in patients treated by continuous ambulatory peritoneal dialysis. (7180661)
1982
49
25-hydroxyvitamin D3 (calcifediol) therapy of juvenile renal osteodystrophy: beneficial effect on linear growth velocity. (7069549)
1982
50
Pseudohypoparathyroidism presenting as renal osteodystrophy. (7466416)
1981

Genetic Variations for Renal Osteodystrophy

Expression for genes affiliated with Renal Osteodystrophy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 56SinoBiological, 54Reactome
See all sources

Pathways related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ACP5, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
Hide members
10.2PTH, VDR
310.1TNFRSF11B, FGF23, PTH
410.1BMP7, MGP, PTH
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
Hide members
10.1PTH, VDR, BGLAP
6
Hide members
9.9DKK1, IGFBP4, SOST
79.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
89.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
9.8PTH, VDR, TNFRSF11B, CALCA, BGLAP
10
Hide members
9.7IGFBP5, IGFBP6, IGFBP4, IGFBP1, CALCA

Compounds for genes affiliated with Renal Osteodystrophy

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1procollagen4510.8ACP5
2estrogen4510.6MGP, VDR
3cycloheximide4510.6IGFBP1, PTH
422-oxacalcitriol4510.2BGLAP, VDR, CASR, CD36
5teriparatide45 1111.2BGLAP, CALCA, TNFRSF11B, CD36
6ibandronate45 1111.2BGLAP, TNFRSF11B, CD36, CALCA
7alfacalcidol45 60 1112.2BGLAP, CALCA, VDR, SLPI
8calcium carbonate4510.2CD36, BGLAP, PTH, CALCA
9etidronate4510.1CALCA, TNFRSF11B, CD36, SLPI, BGLAP
10sevelamer4510.1BGLAP, CASR, FGF23
11vitamin k24510.1SLPI, CD36, CALCA, BGLAP, TNFRSF11B
12ipriflavone4510.1CALCA, SLPI, BGLAP
13tartrate4510.1BGLAP, CALCA, CD36, SLPI, ACP5
14pamidronate45 50 1112.1CASR, TNFRSF11B, CD36, BGLAP, CALCA, PTH
15risedronate45 60 50 29 1114.1SLPI, CD36, TNFRSF11B, CALCA, BGLAP
16clodronate45 50 1112.1VDR, TNFRSF11B, CALCA, ACP5, SLPI, CD36
17zoledronic acid4510.1CALCA, SLPI, CD36, TNFRSF11B, BGLAP
18thiazide4510.1VDR, CALCA, BGLAP, CASR
19estradiol45 11 2412.1SLPI, ACP5, IGFBP6, IGFBP4, IGFBP5
20forskolin45 50 1112.0CALCA, IGFBP5, IGFBP4, PTH, IGFBP6
21titanium4510.0BGLAP, BMP7, SLPI, TNFRSF11B, CD36, ACP5
22denosumab45 1111.0TNFRSF11B, SOST, CALCA
23raloxifene45 29 50 1113.0SLPI, CD36, TNFRSF11B, CALCA, BGLAP, VDR
24pyridinoline459.9BGLAP, CALCA, TNFRSF11B, CD36, SIL1, SLPI
25alendronate45 50 1111.9CD36, PTH, SLPI, VDR, TNFRSF11B, CALCA
26hydrocortisone45 2 60 1112.9CALCA, SLPI, CD36, IGFBP1, TNFRSF11B, BGLAP
27hydroxyproline45 11 2411.8PTH, ACP5, SLPI, BGLAP, CALCA, CD36
28gold459.8IGFBP4, IGFBP5, BMP7, TNFRSF11B, IGFBP1
29thyroxine45 2410.8IGFBP4, VDR, IGFBP5, IGFBP1, PTH, TNFRSF11B
30dexamethasone45 50 29 1112.8VDR, BGLAP, SLPI, ACP5, IGFBP4, BMP7
31phosphorus459.7CALCA, CASR, TNFRSF11B, VDR, FGF23, SLPI
32ribonucleic acid459.7IGFBP4, BMP7, IGFBP1, CASR, IGFBP5, PTH
33serine459.6MGP, IGFBP4, TNFRSF11B, VDR, BMP7, CASR
341,25 dihydroxy vitamin d3459.6PTH, ACP5, FGF23, IGFBP5, IGFBP4, TNFRSF11B
35hydroxyapatite459.5TNFRSF11B, BMP7, MGP, BGLAP, CASR, IGFBP5
36tamoxifen45 50 29 1112.5PTH, SLPI, VDR, IGFBP5, IGFBP1, TNFRSF11B
37deoxypyridinoline459.5PTH, ACP5, SLPI, SIL1, CD36, VDR
38cyclosporin a45 29 6011.5CALCA, CASR, TNFRSF11B, VDR, SLPI, ACP5
39cysteine459.5CASR, SLPI, VDR, CD36, IGFBP4, IGFBP1
40testosterone45 60 11 2412.5SLPI, TNFRSF11B, PTH, BGLAP, VDR, CALCA
41thymidine45 2410.5IGFBP6, IGFBP5, IGFBP1, VDR, SLPI, BMP7
42vegf459.4IGFBP1, BMP7, TNFRSF11B, BGLAP, CALCA, IGFBP4
43heparin45 29 11 2412.4IGFBP4, CD36, BMP7, IGFBP5, IGFBP6, FGF23
44creatinine459.3BMP7, TNFRSF11B, CASR, BGLAP, IGFBP1, IGFBP5
45ascorbic acid45 2410.3VDR, TNFRSF11B, BGLAP, CD36, BMP7, SLPI
4625-hydroxyvitamin d459.3BGLAP, CALCA, CASR, TNFRSF11B, IGFBP4, IGFBP5
47retinoic acid45 2410.2TNFRSF11B, BMP7, MGP, BGLAP, SLPI, VDR
48calcitriol45 60 11 2412.1BGLAP, CALCA, IGFBP1, IGFBP5, VDR, CD36
49vitamin d458.9BGLAP, CALCA, CASR, SOST, TNFRSF11B, BMP7
50calcium45 50 11 2411.5PTH, SLPI, FGF23, CD36, VDR, CALCA

GO Terms for genes affiliated with Renal Osteodystrophy

Sources:
16Gene Ontology
See all sources

Cellular components related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8BMP7, TNFRSF11B, FETUB, CALCA, IGFBP1, IGFBP4
2extracellular spaceGO:0056158.3PTH, BGLAP, CALCA, SOST, FETUB, TNFRSF11B

Biological processes related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.5VDR, FGF23
2regulation of removal of superoxide radicalsGO:200012110.4CD36, BMP7
3negative regulation of bone resorptionGO:04577910.4CALCA, TNFRSF11B
4type B pancreatic cell proliferationGO:04434210.4IGFBP5, IGFBP4
5cellular calcium ion homeostasisGO:00687410.3PTH, VDR, CASR
6negative regulation of protein complex assemblyGO:03133310.2DKK1, SOST
7regulation of cell growthGO:00155810.2IGFBP5, IGFBP6, IGFBP4
8ossificationGO:00150310.2MGP, BMP7, SOST, CASR
9regulation of glucose metabolic processGO:01090610.2IGFBP5, IGFBP4
10regulation of bone mineralizationGO:03050010.1MGP, BGLAP
11positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGFBP4, IGFBP5
12skeletal system developmentGO:0015019.9PTH, BGLAP, TNFRSF11B, BMP7, IGFBP4, VDR
13negative regulation of ossificationGO:0302799.9SOST, CALCA
14signal transductionGO:0071659.7TNFRSF11B, IGFBP1, IGFBP4, IGFBP6, IGFBP5, VDR

Molecular functions related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor I bindingGO:03199410.2IGFBP5, IGFBP6
2structural constituent of boneGO:0081479.8MGP, BGLAP

Products for genes affiliated with Renal Osteodystrophy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renal Osteodystrophy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet