MCID: RNL011
MIFTS: 51

Renal Osteodystrophy malady

Rare diseases, Nephrological diseases, Bone diseases categories
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Summaries for Renal Osteodystrophy

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65Wikipedia, 33MalaCards
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Wikipedia:65 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards: Renal Osteodystrophy, also known as renal rickets, is related to hyperparathyroidism and osteonecrosis. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Development Hedgehog and PTH signaling pathways in bone and cartilage development and FGF signaling pathway. The compounds pyridinoline and calcium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and skeleton.

Aliases & Classifications for Renal Osteodystrophy

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases, Bone diseases


Aliases & Descriptions:

renal osteodystrophy 8 10 45 62
renal rickets 8 43 62
renal osteodystrophy nos 8


External Ids:

Disease Ontology8 DOID:13068
MeSH35 D012080
ICD9CM27 588.0
ICD1025 N25.0

Related Diseases for Renal Osteodystrophy

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17GeneCards, 18GeneDecks
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Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1hyperparathyroidism30.8BGLAP, PTH, TNFRSF11B, ACP5, FGF23, CASR
2osteonecrosis30.6BGLAP
3uremia30.6TNFRSF11B, PTH, CASR
4osteitis fibrosa30.5PTH, CASR, BGLAP
5hyperostosis30.4FGF23, BGLAP
6osteomalacia30.4CASR, BGLAP, TNFRSF11B, FGF23, PTH
7osteosclerosis30.4TNFRSF11B, PTH
8rickets30.3CASR, PTH, BGLAP
9hypercalcemia30.3CASR, FGF23, BGLAP, PTH, TNFRSF11B
10pseudohypoparathyroidism30.2PTH, BGLAP
11metabolic acidosis30.2BGLAP, PTH
12calcinosis30.1PTH, CASR, FGF23
13arthritis30.0ACP5, TNFRSF11B, BGLAP
14primary hyperparathyroidism29.9FGF23, CASR, ACP5, PTH, BGLAP
15chronic kidney failure29.8FGF23, PTH, ACP5, TNFRSF11B, BGLAP, CASR
16peritonitis10.7
17kidney disease10.5
18cervicitis10.4
19spinal stenosis10.3
20slipped capital femoral epiphysis10.3
21end stage renal failure10.2
22hypophosphatasia10.2
23camurati-engelmann disease10.1BGLAP
24hypervitaminosis d10.1FGF23
25synovitis10.1TNFRSF11B
26bone fracture10.1
27fanconi syndrome10.1
28polycystic kidney disease10.1
29blount's disease10.1
30achondroplasia10.1
31psoriatic arthritis10.1
32brachydactyly10.1
33pancytopenia10.1
34cranial nerve palsy10.1
35facial paralysis10.1
36hypertension10.1
37lupus erythematosus10.1
38myelofibrosis10.1
39neuropathy10.1
40periostitis10.1
41renal hypertension10.1
42avascular necrosis of the femoral head10.1
43sagliker syndrome10.1
44pseudohypoparathyroidism type 1b10.1PTH, BGLAP
45parathyroid carcinoma10.1CASR, PTH
46goiter10.0BGLAP, PTH
47x-linked hypophosphatemia10.0FGF23, PTH
48parathyroid adenoma10.0CASR, PTH
49wermer syndrome10.0PTH, CASR
50fibrous dysplasia10.0BGLAP, FGF23

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Symptoms for Renal Osteodystrophy

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Drugs & Therapeutics for Renal Osteodystrophy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

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Anatomical Context for Renal Osteodystrophy

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33MalaCards
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MalaCards organs/tissues related to Renal Osteodystrophy:

33
Bone, Kidney, Bone marrow, Cortex, Spinal cord, Testes

Animal Models for Renal Osteodystrophy or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Renal Osteodystrophy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFRSF11B, PTH, ACP5, FGF23
2MP:00053907.6FGF23, CASR, ACP5, PTH, TNFRSF11B
3MP:00053877.6TNFRSF11B, PTH, ACP5, CASR, FGF23
4MP:00053977.3PTH, ACP5, CASR, FGF23, TNFRSF11B

Publications for Renal Osteodystrophy

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Sources:
52PubMed
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Articles related to Renal Osteodystrophy:

(show top 50)    (show all 504)
idTitleAuthorsYear
1
Severe renal osteodystrophy in a pediatric patient with end-stage renal disease: Sagliker syndrome? (23026501)
2013
2
The influence of medical and nonmedical factors to the progression of renal osteodystrophy. (20102101)
2009
3
Chronic pachymeningitis and bilateral facial paralysis secondary to renal osteodystrophy. (18347262)
2008
4
Clinical and economic burden of fractures in patients with renal osteodystrophy. (17474555)
2007
5
Renal osteodystrophy, phosphate homeostasis, and vascular calcification. (17635820)
2007
6
Serum cross-linked N-terminal telopeptide of type I collagen for evaluation of renal osteodystrophy in hemodialysis patients. (15665550)
2005
7
Utilization of bone histomorphometry in renal osteodystrophy: demonstration of a new approach using data from a prospective study of lanthanum carbonate. (15730056)
2005
8
Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease. (15882311)
2005
9
Localized jaw enlargement in renal osteodystrophy: report of a case and review of the literature. (14716259)
2004
10
New aspects in the management of renal osteodystrophy]. (15669206)
2004
11
Radiologic features of renal osteodystrophy in a patient with "normal" bone mineralization. (12970649)
2003
12
Cytokine accumulation in osteitis fibrosa of renal osteodystrophy. (11743611)
2002
13
Renal osteodystrophy. (12041521)
2002
14
Adynamic renal osteodystrophy: is there a problem? (11518793)
2001
15
Management of secondary hyperparathyroidism: the gap between diagnosis and treatment. The Renal Osteodystrophy Multicenter Enquiry. (10981485)
2000
16
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
17
High frequency of iron bone deposits in a Mexican population with renal osteodystrophy. (9568820)
1998
18
Biochemical markers of bone turnover in the diagnosis of renal osteodystrophy: what do we have, what do we need? (9568817)
1998
19
Magnetic resonance imaging of renal osteodystrophy in children. (9361047)
1997
20
Myelofibrosis secondary to renal osteodystrophy. (8730443)
1996
21
Secondary hyperparathyroidism and renal osteodystrophy. (7728664)
1995
22
Detection of subtle aluminum-related renal osteodystrophy. (7683072)
1993
23
Renal osteodystrophy in diabetic patients. (8355457)
1993
24
Comparison of renal osteodystrophy in patients undergoing continuous ambulatory peritoneal dialysis and hemodialysis. (8399637)
1993
25
Renal osteodystrophy and hypercalcemia. (8512774)
1993
26
Maxillary brown tumor as manifestation of renal osteodystrophy. (8341400)
1993
27
PTH and bone markers of renal osteodystrophy in predialysis chronic renal failure. (1300330)
1992
28
Ketodiet, physiological calcium intake and native vitamin D improve renal osteodystrophy. (1453606)
1992
29
The radiographic spectrum of renal osteodystrophy. (1986484)
1991
30
Prevention of renal osteodystrophy. (1813786)
1991
31
Diagnostic evaluation of plasma free gamma-carboxyglutamic acid in maintenance hemodialytic patients with renal osteodystrophy]. (2082053)
1990
32
Is renal osteodystrophy rare in the tropics? (2362644)
1990
33
Efficacy of calcium carbonate and low-dose vitamin D/1,25(OH)2D3 in reducing the risk of developing renal osteodystrophy in children on continuous ambulatory peritoneal dialysis. (2088463)
1990
34
Diagnosis of renal osteodystrophy with the Jamshidi needle biopsy. (2750179)
1989
35
51Cr-EDTA/99Tcm-MDP ratio: a simple non-invasive method for assessing renal osteodystrophy. (2496884)
1989
36
1,25 (OH)2 vitamin D3 deficiency and renal osteodystrophy: should its well-accepted pathogenetic role in secondary hyperparathyroidism lead to its systematic preventive therapeutic use? (3126450)
1987
37
Primary bone oxalosis: the roles of oxalate deposits and renal osteodystrophy. (3593609)
1987
38
Behavior of the vitamin D endocrine system in the development of renal osteodystrophy. (3299575)
1986
39
Renal osteodystrophy in asymptomatic hemodialysis patients: evidence of a sex-dependent distribution and predictive value of serum aluminum measurements. (3812472)
1986
40
The effect of hemodialysis, vitamin D metabolites and renal transplantation on the skeletal demineralization associated with renal osteodystrophy: a computerized histomorphometric analysis. (3542321)
1986
41
Renal osteodystrophy with facial hyperostosis and 'rubber jaw' in an adult dog. (16031185)
1985
42
Total parathyroidectomy and parathyroid autograft for renal osteodystrophy: analysis of the cause of failure. (4013363)
1985
43
Observations on computerized quantitative bone scintigraphy in renal osteodystrophy. (6437823)
1984
44
Consequences of avascular necrosis of the femoral head in aluminium-related renal osteodystrophy and the role of endochondral ossification in the repair process. (6402524)
1983
45
Caring for patients with renal osteodystrophy. (6552189)
1983
46
Bone aluminum deposition in renal osteodystrophy. (6185842)
1983
47
Therapeutic effects of 25-hydroxycholecalciferol and sodium etidronate on renal osteodystrophy. (6820473)
1982
48
Renal osteodystrophy in children with chronic renal failure: an unexpectedly common and incapactating complication. (6982452)
1982
49
Radiographic interpretation of the mandibular angular cortex: a diagnostic tool in metabolic bone loss. Part II. Renal osteodystrophy. (6954448)
1982
50
Renal osteodystrophy presenting as periurethral abscess. (7147513)
1982

Variations for Renal Osteodystrophy

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Expression for genes affiliated with Renal Osteodystrophy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN
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Pathways related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6BGLAP, PTH
29.5FGF23, BGLAP
39.0ACP5, TNFRSF11B
49.0ACP5, TNFRSF11B
5
Show member pathways
RANKL/RANK Signaling Pathway38
Apoptosis and survival APRIL and BAFF signaling60
9.0ACP5, TNFRSF11B
69.0PTH, TNFRSF11B, BGLAP
78.9FGF23, PTH, TNFRSF11B

Compounds for genes affiliated with Renal Osteodystrophy

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Sources:
45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1pyridinoline4510.3TNFRSF11B
2calcium carbonate459.9PTH, BGLAP
322-oxacalcitriol459.9BGLAP, CASR
4deflazacort459.8TNFRSF11B, BGLAP
5teriparatide45 1110.8BGLAP, TNFRSF11B
6thiazide459.8CASR, BGLAP
7etidronate459.8TNFRSF11B, BGLAP
8ibandronate45 1110.7BGLAP, TNFRSF11B
9strontium459.7TNFRSF11B, CASR
10vitamin k2459.7TNFRSF11B, BGLAP
11risedronate45 51 29 61 1113.7TNFRSF11B, BGLAP
12hydrochlorothiazide45 29 51 24 1113.6CASR, BGLAP
13zoledronic acid459.5TNFRSF11B, BGLAP
14tartrate459.5BGLAP, ACP5
15tibolone459.4BGLAP, ACP5
16sevelamer459.4BGLAP, FGF23, CASR
17ns 39845 6110.4TNFRSF11B, BGLAP
18infliximab45 51 1111.4TNFRSF11B, BGLAP
19alendronate45 51 1111.4PTH, BGLAP, TNFRSF11B
20thyroxine45 2410.3TNFRSF11B, PTH, BGLAP
21pmma459.2ACP5, TNFRSF11B
22tamoxifen45 51 29 1112.2TNFRSF11B, PTH, BGLAP
23raloxifene45 51 29 1112.1TNFRSF11B, BGLAP
24clodronate45 51 1111.0TNFRSF11B, ACP5, BGLAP
25forskolin45 51 1111.0TNFRSF11B, PTH, CASR
26titanium459.0BGLAP, TNFRSF11B, ACP5
27azathioprine45 3 51 1112.0BGLAP, TNFRSF11B, ACP5
28pamidronate45 51 1110.9BGLAP, PTH, CASR, TNFRSF11B
29arginine458.9CASR, FGF23, BGLAP, PTH
30sodium45 249.8CASR, PTH, TNFRSF11B
31deoxypyridinoline458.6PTH, ACP5, TNFRSF11B, BGLAP
32hydroxyproline45 24 1110.6ACP5, PTH, TNFRSF11B, BGLAP
33procollagen458.6ACP5, TNFRSF11B, PTH, BGLAP
34estradiol45 24 1110.6PTH, ACP5, TNFRSF11B, BGLAP
35dexamethasone45 51 29 1111.5ACP5, TNFRSF11B, PTH, BGLAP
36cyclosporin a45 29 6110.4CASR, TNFRSF11B, ACP5, BGLAP
37heparin45 29 24 1111.4TNFRSF11B, FGF23, BGLAP, ACP5
38nitric oxide45 24 1110.4CASR, TNFRSF11B, PTH, ACP5
39cysteine458.3BGLAP, TNFRSF11B, ACP5, CASR
40pge2458.1TNFRSF11B, BGLAP, CASR, PTH, ACP5
41estrogen458.0BGLAP, TNFRSF11B, CASR, PTH, ACP5
42hydroxyapatite458.0TNFRSF11B, BGLAP, ACP5, CASR, FGF23
43tyrosine457.9TNFRSF11B, FGF23, PTH, ACP5, CASR
4425-hydroxyvitamin d457.6CASR, FGF23, ACP5, PTH, BGLAP, TNFRSF11B
45phosphorus457.6FGF23, CASR, ACP5, PTH, TNFRSF11B, BGLAP
461,25 dihydroxy vitamin d3457.6FGF23, ACP5, PTH, TNFRSF11B, BGLAP, CASR
47calcitriol45 61 24 1110.6BGLAP, ACP5, TNFRSF11B, FGF23, PTH, CASR
48vitamin d457.6PTH, TNFRSF11B, ACP5, CASR, FGF23, BGLAP
49creatinine457.6FGF23, BGLAP, CASR, TNFRSF11B, PTH, ACP5
50calcium45 51 24 1110.5FGF23, PTH, BGLAP, CASR, ACP5, TNFRSF11B

GO Terms for genes affiliated with Renal Osteodystrophy

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16Gene Ontology
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Cellular components related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.5FGF23, PTH, TNFRSF11B, BGLAP
2extracellular spaceGO:0056158.2FGF23, PTH, TNFRSF11B, BGLAP

Biological processes related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1response to vitamin DGO:0332809.7PTH, BGLAP
2response to ethanolGO:0454719.6PTH, BGLAP
3bone resorptionGO:0454539.3ACP5, PTH
4response to estrogenGO:0436279.3TNFRSF11B, BGLAP
5cellular calcium ion homeostasisGO:0068749.2CASR, PTH
6skeletal system developmentGO:0015019.1PTH, TNFRSF11B, BGLAP
7response to drugGO:0424939.0BGLAP, TNFRSF11B, PTH

Products for genes affiliated with Renal Osteodystrophy

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Sources for Renal Osteodystrophy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet