MCID: RNL011
MIFTS: 56

Renal Osteodystrophy malady

Nephrological diseases, Bone diseases categories

Summaries for Renal Osteodystrophy

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63Wikipedia, 32MalaCards
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Wikipedia:63 Renal osteodystrophy or chronic kidney disease-mineral and bone disorder (CKD-MBD) is a bone pathology,... more...

MalaCards: Renal Osteodystrophy, also known as renal rickets, is related to peritonitis and hyperparathyroidism. An important gene associated with Renal Osteodystrophy is PTH (parathyroid hormone), and among its related pathways are Osteoclast Signaling and Vitamin D2 (ergocalciferol) metabolism. The compounds procollagen and estrogen have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and bone marrow, and related mouse phenotypes are limbs/digits/tail and endocrine/exocrine gland.

Aliases & Classifications for Renal Osteodystrophy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 42NIH Rare Diseases, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Bone diseases


Aliases & Descriptions:

renal osteodystrophy 8 10 44 60
renal rickets 8 42 60
renal osteodystrophy nos 8


External Ids:

Disease Ontology8 DOID:13068
ICD9CM27 588.0
MeSH34 D012080
ICD1025 N25.0

Related Diseases for Renal Osteodystrophy

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17GeneCards, 18GeneDecks
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Diseases related to Renal Osteodystrophy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 131)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis31.0SLPI
2hyperparathyroidism31.0BGLAP, CALCA, CASR, TNFRSF11B, IGFBP4, VDR
3uremia30.5CASR, TNFRSF11B, IGFBP1, VDR, PTH
4osteomalacia30.5PTH, SLPI, FGF23, CD36, BGLAP, CALCA
5osteonecrosis30.4BGLAP
6osteitis fibrosa30.4PTH, CASR, BGLAP
7spinal stenosis30.4BMP7, CALCA
8hypercalcemia30.4BGLAP, CALCA, CASR, TNFRSF11B, MGP, VDR
9hyperostosis30.2FGF23, SOST, BGLAP
10osteosclerosis30.2PTH, TNFRSF11B, SOST
11rickets30.2PTH, CD36, VDR, CASR, BGLAP
12hypertension30.0CALCA, PTH
13metabolic acidosis30.0PTH, BGLAP
14calcinosis30.0PTH, FGF23, CASR
15pseudohypoparathyroidism30.0PTH, CALCA, BGLAP
16arthritis30.0BGLAP, CALCA, TNFRSF11B, BMP7, VDR, ACP5
17primary hyperparathyroidism30.0VDR, CD36, FGF23, ACP5, PTH, IGFBP1
18chronic kidney failure30.0BGLAP, CASR, TNFRSF11B, BMP7, IGFBP1, IGFBP4
19kidney disease10.5
20cervicitis10.3
21bone fracture10.3
22end stage renal failure10.2
23hypophosphatasia10.2
24renal vascular disease10.2
25vascular disease10.2
26blount's disease10.0
27achondroplasia10.0
28psoriatic arthritis10.0
29brachydactyly10.0
30pancytopenia10.0
31fanconi syndrome10.0
32polycystic kidney disease10.0
33adult syndrome10.0
34cranial nerve palsy10.0
35facial paralysis10.0
36lupus erythematosus10.0
37myelofibrosis10.0
38neuropathy10.0
39periostitis10.0
40renal hypertension10.0
41vitamin metabolic disorder10.0
42pancreatitis10.0CASR
43obesity10.0IGFBP1
44prostatitis10.0VDR
45thyroiditis10.0CALCA
46gingivitis10.0TNFRSF11B
47insulin resistance10.0IGFBP1
48hepatitis10.0IGFBP1
49liver cirrhosis10.0SLPI
50hypervitaminosis d10.0FGF23

Graphical network of the top 20 diseases related to Renal Osteodystrophy:



Diseases related to renal osteodystrophy

Clinical Features for Renal Osteodystrophy

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Drugs & Therapeutics for Renal Osteodystrophy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renal Osteodystrophy

Drug clinical trials:

Search ClinicalTrials for Renal Osteodystrophy

Search NIH Clinical Center for Renal Osteodystrophy

Search CenterWatch for Renal Osteodystrophy

Genetic Tests for Renal Osteodystrophy

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Anatomical Context for Renal Osteodystrophy

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32MalaCards
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MalaCards organs/tissues related to Renal Osteodystrophy:

32
Bone, Kidney, Bone marrow, Cortex, Spinal cord, Testes

Animal Models for Renal Osteodystrophy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Osteodystrophy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537110.1SOST, FGF23, ACP5, DKK1
2MP:00053799.9VDR, IGFBP5, IGFBP4, BMP7
3MP:00053679.9CASR, FGF23, DKK1, MGP, BMP7
4MP:00053909.7FGF23, ACP5, BMP7, TNFRSF11B, MGP, DKK1
5MP:00053879.2CASR, TNFRSF11B, BMP7, IGFBP1, VDR, CD36
6MP:00053859.1PTH, FGF23, CD36, VDR, MGP, TNFRSF11B
7MP:00053789.1PTH, CASR, SOST, FGF23, CD36, VDR
8MP:00053768.9IGFBP5, IGFBP4, SOST, CASR, CALCA, CD36
9MP:00107688.9TNFRSF11B, CALCA, CASR, BMP7, MGP, DKK1

Publications for Renal Osteodystrophy

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50PubMed
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Articles related to Renal Osteodystrophy:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Bisphosphonate therapy in renal osteodystrophy--a review. (22760876)
2013
2
Recent advances in the noninvasive diagnosis of renal osteodystrophy. (23802194)
2013
3
Role of bone biopsy in renal osteodystrophy. (19112214)
2009
4
Effects of treatment of renal osteodystrophy on bone histology. (18988701)
2008
5
Molecular diagnosis and clinical characterization of pseudohypoparathyroidism type-Ib in a patient with mild Albright's hereditary osteodystrophy-like features, epileptic seizures, and defective renal handling of uric acid. (18626245)
2008
6
Prevention and treatment of renal osteodystrophy in children on chronic renal failure: European guidelines. (16247644)
2006
7
Diagnosis of renal osteodystrophy. (16884394)
2006
8
Calcimimetics: a new tool for management of hyperparathyroidism and renal osteodystrophy in patients with chronic kidney disease. (15882311)
2005
9
Specific measurement of PTH (1-84) in various forms of renal osteodystrophy (ROD) as assessed by bone histomorphometry. (16105052)
2005
10
New worldwide trends in presentation of renal osteodystrophy and its relationship to parathyroid hormone levels. (15847255)
2005
11
Introduction. Renal osteodystrophy. (14730503)
2004
12
The renal osteodystrophy pattern in Brazil and Uruguay: an overview. (12753266)
2003
13
Bone density measurements in pediatric patients with renal osteodystrophy. (12712376)
2003
14
Pathophysiology and recent advances in the management of renal osteodystrophy. (12469904)
2002
15
Adynamic renal osteodystrophy: is there a problem? (11518793)
2001
16
Oral and maxillofacial pathology case of the month. Renal-osteodystrophy induced macrognathia. (11494795)
2001
17
Calcitonin as a helper of calcitriol therapy in renal osteodystrophy. (11096303)
2000
18
The role of cytokines in skeletal remodelling: possible consequences for renal osteodystrophy. (10862628)
2000
19
Insulin-like growth factor system components in hyperparathyroidism and renal osteodystrophy. (10652019)
2000
20
Diagnosis of renal osteodystrophy: when and how to use biochemical markers and non-invasive methods; when bone biopsy is needed. (11073268)
2000
21
Introduction to renal osteodystrophy: calcium metabolism in health and uremia. (10372833)
1999
22
Renal osteodystrophy: new insights in pathophysiology and treatment modalities with special emphasis on the insulin-like growth factor system. (9678423)
1998
23
Spectrum of renal osteodystrophy in dialysis patients at a tertiary hospital, riyadh, saudi arabia. (18408287)
1998
24
Magnetic resonance imaging of renal osteodystrophy in children. (9361047)
1997
25
Suppressive effect of calcium on parathyroid hormone release in adynamic renal osteodystrophy and secondary hyperparathyroidism. (9150477)
1997
26
Bone alkaline phosphatase isoenzyme in renal osteodystrophy. (8840311)
1996
27
The management of renal osteodystrophy. (8897578)
1996
28
Do patients who are treated with calcitriol for renal osteodystrophy also need vitamin D3 therapy? (7794703)
1995
29
Patient education: renal osteodystrophy and adequacy of dialysis. (7872821)
1994
30
Recent advances in the management of renal osteodystrophy in children. (7859020)
1993
31
Renal osteodystrophy--pathophysiological aspects. (8569601)
1993
32
The relevance of mineralization lag time in the evaluation of histologic changes in renal osteodystrophy. (8491052)
1993
33
Non-invasive measurements of bone mass in adult renal osteodystrophy. (8363886)
1993
34
Renal osteodystrophy in CAPD. (1680434)
1991
35
Efficacy of calcium carbonate and low-dose vitamin D/1,25(OH)2D3 in reducing the risk of developing renal osteodystrophy in children on continuous ambulatory peritoneal dialysis. (2088463)
1990
36
Therapeutic effect of keto acids on renal osteodystrophy. A prospective controlled study. (2132299)
1990
37
Studies of circulating parathyroid hormone following parathyroidectomy in renal osteodystrophy. (2073746)
1990
38
Diagnosis of renal osteodystrophy with the Jamshidi needle biopsy. (2750179)
1989
39
Tumoral calcification in association with renal osteodystrophy. (2548256)
1989
40
Renal osteodystrophy: some new questions on an old disorder. (3285668)
1988
41
Distal phalangeal brachydactyly secondary to healed renal osteodystrophy. (3616669)
1987
42
"High-dose" calcitriol for control of renal osteodystrophy in children on CAPD. (3626302)
1987
43
Serum bone Gla-protein in renal osteodystrophy: comparison with bone histomorphometry. (3488998)
1986
44
Renal osteodystrophy in patients on hemodialysis for more than 10 years. (3807834)
1986
45
Dialysis osteomalacia and aluminum toxicity: a form of renal osteodystrophy. (3848318)
1985
46
Aluminum: toxin or innocent bystander in renal osteodystrophy. (3904426)
1985
47
Parathyroid hormone measurements in hemodialysis patients as assessments of renal osteodystrophy. (6610110)
1984
48
Renal osteodystrophy in children treated with 1,25-dihydroxy-cholecalciferol [1,25-(OH)2D3]. Histologic bone studies. (6547559)
1984
49
Vitamin D compounds and renal osteodystrophy. (6689416)
1983
50
Interrelationship of serum 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D in juvenile renal osteodystrophy after therapy with 25-hydroxyvitamin D3. (6897822)
1982

Genetic Variations for Renal Osteodystrophy

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Expression for genes affiliated with Renal Osteodystrophy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Osteodystrophy

Search GEO for disease gene expression data for Renal Osteodystrophy.

Pathways for genes affiliated with Renal Osteodystrophy

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 55SinoBiological, 53Reactome
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Pathways related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ACP5, TNFRSF11B
2
Vitamin D2 (ergocalciferol) metabolism
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10.2PTH, VDR
310.1TNFRSF11B, FGF23, PTH
410.1BMP7, MGP, PTH
5
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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10.1PTH, VDR, BGLAP
6
Hide members
9.9DKK1, IGFBP4, SOST
79.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
89.9IGFBP1, IGFBP4, IGFBP6, IGFBP5
9
Transcription Role of VDR in regulation of genes involved in osteoporosis
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9.8PTH, VDR, TNFRSF11B, CALCA, BGLAP
10
Hide members
9.7IGFBP5, IGFBP6, IGFBP4, IGFBP1, CALCA

Compounds for genes affiliated with Renal Osteodystrophy

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Sources:
44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show top 50)    (show all 109)
idCompoundScoreTop Affiliating Genes
1procollagen4410.8ACP5
2estrogen4410.6VDR, MGP
3cycloheximide4410.6PTH, IGFBP1
422-oxacalcitriol4410.2BGLAP, CASR, VDR, CD36
5teriparatide44 1111.2BGLAP, CALCA, TNFRSF11B, CD36
6ibandronate44 1111.2BGLAP, CALCA, TNFRSF11B, CD36
7alfacalcidol44 59 1112.2BGLAP, CALCA, VDR, SLPI
8calcium carbonate4410.2BGLAP, CALCA, CD36, PTH
9etidronate4410.1CD36, TNFRSF11B, CALCA, BGLAP, SLPI
10sevelamer4410.1BGLAP, CASR, FGF23
11vitamin k24410.1BGLAP, CALCA, TNFRSF11B, CD36, SLPI
12ipriflavone4410.1BGLAP, CALCA, SLPI
13tartrate4410.1BGLAP, CALCA, CD36, SLPI, ACP5
14pamidronate44 49 1112.1BGLAP, CALCA, CASR, TNFRSF11B, CD36, PTH
15risedronate44 59 49 28 1114.1BGLAP, CALCA, TNFRSF11B, CD36, SLPI
16clodronate44 49 1112.1ACP5, SLPI, CD36, VDR, TNFRSF11B, CALCA
17zoledronic acid4410.1BGLAP, CALCA, TNFRSF11B, CD36, SLPI
18thiazide4410.1BGLAP, CALCA, CASR, VDR
19estradiol44 11 2412.1IGFBP4, IGFBP6, IGFBP5, SLPI, ACP5
20forskolin44 49 1112.0CALCA, IGFBP4, IGFBP6, IGFBP5, PTH
21titanium4410.0BGLAP, TNFRSF11B, BMP7, CD36, SLPI, ACP5
22denosumab44 1111.0CALCA, SOST, TNFRSF11B
23raloxifene44 28 49 1113.0BGLAP, CALCA, TNFRSF11B, VDR, CD36, SLPI
24pyridinoline449.9ACP5, SLPI, SIL1, CD36, TNFRSF11B, CALCA
25alendronate44 49 1111.9BGLAP, CALCA, TNFRSF11B, VDR, CD36, SLPI
26hydrocortisone44 2 59 1112.9BGLAP, CALCA, TNFRSF11B, IGFBP1, CD36, SLPI
27hydroxyproline44 11 2411.8BGLAP, CALCA, TNFRSF11B, PTH, ACP5, SLPI
28gold449.8IGFBP5, IGFBP4, IGFBP1, BMP7, TNFRSF11B
29thyroxine44 2410.8BGLAP, CALCA, TNFRSF11B, IGFBP1, IGFBP4, IGFBP5
30dexamethasone44 49 28 1112.8BGLAP, TNFRSF11B, BMP7, IGFBP4, VDR, SLPI
31phosphorus449.8PTH, ACP5, SLPI, FGF23, VDR, TNFRSF11B
32ribonucleic acid449.7CASR, BMP7, IGFBP1, IGFBP4, IGFBP6, IGFBP5
33serine449.6BGLAP, CASR, TNFRSF11B, BMP7, MGP, IGFBP4
341,25 dihydroxy vitamin d3449.6VDR, IGFBP5, IGFBP4, TNFRSF11B, CASR, CALCA
35deoxypyridinoline449.6BGLAP, CALCA, TNFRSF11B, IGFBP1, PTH, ACP5
36hydroxyapatite449.6ACP5, SLPI, FGF23, CD36, IGFBP5, MGP
37tamoxifen44 49 28 1112.5BGLAP, TNFRSF11B, IGFBP1, IGFBP4, IGFBP6, IGFBP5
38cyclosporin a44 28 5911.5BGLAP, CALCA, CASR, TNFRSF11B, VDR, SLPI
39cysteine449.5CASR, SOST, IGFBP1, IGFBP4, VDR, CD36
40testosterone44 59 11 2412.5BGLAP, CALCA, TNFRSF11B, IGFBP1, IGFBP4, IGFBP5
41thymidine44 2410.5BMP7, IGFBP1, IGFBP4, IGFBP6, IGFBP5, VDR
42vegf449.4BMP7, TNFRSF11B, CALCA, BGLAP, IGFBP1, IGFBP4
43heparin44 28 11 2412.4BGLAP, TNFRSF11B, BMP7, IGFBP4, IGFBP6, IGFBP5
44creatinine449.3PTH, ACP5, SLPI, FGF23, CD36, VDR
45ascorbic acid44 2410.3BGLAP, TNFRSF11B, BMP7, VDR, CD36, SLPI
4625-hydroxyvitamin d449.3SLPI, FGF23, CD36, VDR, IGFBP5, IGFBP4
47retinoic acid44 2410.2MGP, BMP7, TNFRSF11B, BGLAP, IGFBP1, IGFBP4
48calcitriol44 59 11 2412.0PTH, ACP5, SLPI, FGF23, CD36, VDR
49vitamin d448.9BGLAP, CALCA, CASR, SOST, PTH, ACP5
50calcium44 49 11 2411.5MGP, BMP7, TNFRSF11B, SOST, CASR, CALCA

GO Terms for genes affiliated with Renal Osteodystrophy

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16Gene Ontology
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Cellular components related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8BMP7, TNFRSF11B, FETUB, CALCA, IGFBP1, IGFBP4
2extracellular spaceGO:0056158.3PTH, BGLAP, CALCA, SOST, FETUB, TNFRSF11B

Biological processes related to Renal Osteodystrophy according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of vitamin D 24-hydroxylase activityGO:01098010.5VDR, FGF23
2regulation of removal of superoxide radicalsGO:200012110.4CD36, BMP7
3negative regulation of bone resorptionGO:04577910.4CALCA, TNFRSF11B
4type B pancreatic cell proliferationGO:04434210.4IGFBP5, IGFBP4
5cellular calcium ion homeostasisGO:00687410.3PTH, VDR, CASR
6negative regulation of protein complex assemblyGO:03133310.2DKK1, SOST
7regulation of cell growthGO:00155810.2IGFBP5, IGFBP6, IGFBP4
8ossificationGO:00150310.2MGP, BMP7, SOST, CASR
9regulation of glucose metabolic processGO:01090610.2IGFBP5, IGFBP4
10regulation of bone mineralizationGO:03050010.1MGP, BGLAP
11positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.1IGFBP4, IGFBP5
12skeletal system developmentGO:0015019.9PTH, BGLAP, TNFRSF11B, BMP7, IGFBP4, VDR
13negative regulation of ossificationGO:0302799.9SOST, CALCA
14signal transductionGO:0071659.7TNFRSF11B, IGFBP1, IGFBP4, IGFBP6, IGFBP5, VDR

Molecular functions related to Renal Osteodystrophy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor I bindingGO:03199410.2IGFBP5, IGFBP6
2structural constituent of boneGO:0081479.8MGP, BGLAP

Products for genes affiliated with Renal Osteodystrophy

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  • Antibodies
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Sources for Renal Osteodystrophy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet