Renal Tubular Acidosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

MCID: RNL007 MIFTS: 58	Renal Tubular Acidosis malady Nephrological diseases category
8 drugs, 60 genes, 10 tissues, 133 related diseases, clinical trials.

Summaries for Renal Tubular Acidosis

Sources:
⁶³Wikipedia, ³²MalaCards
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Wikipedia:⁶³ Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body... more...

MalaCards: Renal Tubular Acidosis, also known as acidosis renal tubular, is related to nephrocalcinosis and osteopetrosis. An important gene associated with Renal Tubular Acidosis is ATP6V1B1 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1), and among its related pathways are Multifunctional anion exchangers and O2/CO2 exchange in erythrocytes. The drugs citric acid and sodium bicarbonate and the compounds Methyclothiazide and u 104 have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and liver, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Renal Tubular Acidosis

Sources:
⁸Disease Ontology, ⁴²NIH Rare Diseases, ¹⁰DISEASES, ⁴⁴Novoseek, ⁶⁰UMLS, ⁵⁶SNOMED-CT, ³⁴MeSH, ³⁹NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases

Aliases & Descriptions:

renal tubular acidosis ⁸ ⁴² ¹⁰ ⁶⁰

acidosis renal tubular ⁴⁴

renal tubule acidosis ⁸

External Ids:

Disease Ontology⁸ DOID:14219

MeSH³⁴ D000141

SNOMED-CT⁵⁶ 1776003

NCIt³⁹ C28129

UMLS⁶⁰ C0001126

Related Diseases for Renal Tubular Acidosis

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Renal Tubular Acidosis family:

Primary Renal Tubular Acidosis

Diseases related to Renal Tubular Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 133)

id	Related Disease	Score	Top Affiliating Genes
1	nephrocalcinosis	31.4	ATP6V0A4, ATP6V1B1, SLC4A1, CA2
2	osteopetrosis	31.1	TCIRG1, SLC4A2, DNAH8, CA2
3	renal tubular acidosis, distal, autosomal recessive	31.0	ATP6V0A4, ATP6V1B1, SLC4A1
4	metabolic acidosis	30.9	CA2, SCNN1G, ATP6AP1, ATP6V0A4, ATP6V1B1, SLC4A1
5	renal tubular acidosis, distal	30.8	AMBP, CA2, ATP6V0A4, ATP6V1B1, DNAH8, SLC4A1
6	nephrolithiasis	30.7	SLC26A6, SLC26A1
7	arthritis	30.5	AMBP
8	rheumatoid arthritis	30.4	AMBP, DNAH8
9	glaucoma	30.4	CA14, SLC4A4, CA4, CA2
10	primary hyperoxaluria	30.4	AMBP, DNAH8
11	hereditary elliptocytosis	30.4	SLC4A2, SLC4A1
12	renal tubular acidosis with deafness	10.8
13	osteomalacia	10.7
14	diabetes insipidus	10.7
15	nephrogenic diabetes insipidus	10.6
16	primary biliary cirrhosis	10.6
17	systemic lupus erythematosus	10.6
18	hypokalemic periodic paralysis	10.6
19	lupus erythematosus	10.6
20	renal tubular acidosis, distal, autosomal dominant	10.6
21	proximal renal tubular acidosis with ocular abnormalities	10.6
22	renal tubular acidosis, distal, ad	10.6
23	sensorineural hearing loss	10.6
24	cerebritis	10.6
25	fanconi syndrome	10.6
26	neuroaxonal dystrophy renal tubular acidosis	10.6
27	hyperparathyroidism	10.5
28	osteopetrosis, autosomal recessive 3, with renal tubular acidosis	10.5
29	sjogren's syndrome	10.5
30	hypothyroidism	10.5
31	respiratory failure	10.5
32	renal tubular acidosis, distal, type 3	10.5
33	hypercalcemia	10.4
34	osteoporosis	10.4
35	diabetes mellitus	10.4
36	thyroiditis	10.4
37	primary hyperparathyroidism	10.4
38	cystinosis	10.4
39	hereditary spherocytosis	10.4
40	hepatitis	10.4
41	hyperthyroidism	10.4
42	renal tubular acidosis progressive nerve deafness	10.4
43	osteopetrosis with renal tubular acidosis	10.4
44	renal tubular acidosis, distal, with hemolytic anemia	10.4
45	renal tubular acidosis, distal, ar	10.4
46	hyperkalemic renal tubular acidosis	10.4
47	focal segmental glomerulosclerosis	10.3
48	urethritis	10.3
49	hypophosphatemia	10.3
50	hypoparathyroidism	10.3

Graphical network of the top 20 diseases related to Renal Tubular Acidosis:

Clinical Features for Renal Tubular Acidosis

Drugs & Therapeutics for Renal Tubular Acidosis

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶⁰UMLS, ⁴⁰NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Renal Tubular Acidosis

Drug clinical trials:

Search ClinicalTrials for Renal Tubular Acidosis

Search NIH Clinical Center for Renal Tubular Acidosis

Search CenterWatch for Renal Tubular Acidosis

Inferred drug relations via UMLS⁶⁰/NDF-RT⁴⁰:

Show with subtypes

citric acid

citric acid, anhydrous

citric acid,hydrous

citric acid granules

citric acid monohydrate

citrus naringinine

sodium bicarbonate

sodium bicarbonate powder

Genetic Tests for Renal Tubular Acidosis

Anatomical Context for Renal Tubular Acidosis

Sources:
³⁰LifeMap Discovery™, ³²MalaCards
See all sources

MalaCards organs/tissues related to Renal Tubular Acidosis:

³²

Kidney, Bone, Liver, Thyroid, Brain, Colon, Testes, Lung, Heart

The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Renal Tubular Acidosis:

id	TissueAnatomical CompartmentCell	Relevance
1	KidneyProximal TubuleProximal Tubule Cells	Potential therapeutic candidate, affected by disease

Animal Models for Renal Tubular Acidosis or affiliated genes

Sources:
³⁶MGI
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MGI Mouse Phenotypes related to Renal Tubular Acidosis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system phenotype	MP:0005367	10.0	SLC4A4, CA2, SCNN1G, ATP6V0A4, ATP6V1B1, SLC4A1
2	growth/size phenotype	MP:0005378	9.9	CA2, CA4, SCNN1G, ATP6V0A4, SLC4A1, SLC4A2
3	homeostasis/metabolism phenotype	MP:0005376	9.6	CA14, CA2, CA4, SCNN1G, ATP6V0A4, ATP6V1B1
4	mortality/aging	MP:0010768	9.4	CA14, CA2, CA4, SCNN1G, ATP6AP1, ATP6V0A4

Publications for Renal Tubular Acidosis

Sources:
⁵⁰PubMed
See all sources

Articles related to Renal Tubular Acidosis:

(show top 50) (show all 563)

id	Title	Authors	Year
1	Mutational analyses of the ATP6V1B1 and ATP6V0A4 genes in patients with primary distal renal tubular acidosis. (23729491)	Miura K.... Igarashi T.	2013
2	A distal (type 1) renal tubular acidosis case that mimic coronary ischemia. (23906332)	TekAse H.... A9ztA1rk S.	2013
3	Type 3 renal tubular acidosis. (23439805)	Goswami R.P.... Ghosh A.	2012
4	A distal renal tubular acidosis showing hyperammonemia and hyperlactacidemia. (23173413)	Ripoli C.... Nurchi A.M.	2012
5	Prevalence and densitometric characteristics of incomplete distal renal tubular acidosis in men with recurrent calcium nephrolithiasis. (21713545)	Arampatzis S.... Hess B.	2012
6	Prevalence and risk factors of renal tubular acidosis after kidney transplantation. (22368897)	Malik S.I.... Zafar M.N.	2011
7	Renal tubular acidosis associated with zonisamide therapy in a dog. (22092642)	Cook A.K.... Barr J.	2011
8	Clinical profile of distal renal tubular acidosis. (21422623)	Jha R.... Modi K.D.	2011
9	Tubulointerstitial nephritis and renal tubular acidosis of different types are rare but important complications of primary biliary cirrhosis. (20466658)	Komatsuda A.... Sawada K.	2010
10	A novel SLC4A1 variant in an autosomal dominant distal renal tubular acidosis family with a severe phenotype. (20960171)	Shao L.... Miao Z.	2010
11	Diabetes mellitus and renal tubular acidosis in primary SjAPgren's syndrome. (21121214)	Prakash E.B.... Fernando M.E.	2010
12	Severe hypophosphatemic osteomalacia with Fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis. (19252361)	Bando H.... Kaji H.	2009
13	Compound mutations in human anion exchanger 1 are associated with complete distal renal tubular acidosis and hereditary spherocytosis. (19625994)	Chang Y.H.... Lu P.J.	2009
14	G418-mediated ribosomal read-through of a nonsense mutation causing autosomal recessive proximal renal tubular acidosis. (18614622)	Azimov R.... Kurtz I.	2008
15	Atypical presentation of distal renal tubular acidosis in two siblings. (18386070)	Tasic V.... Cheong H.I.	2008
16	Distal renal tubular acidosis associated with anion exchanger 1 mutations in children in Thailand. (17533027)	Khositseth S.... Yenchitsomanus P.T.	2007
17	Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). (17409310)	Stehberger P.A.... Wagner C.A.	2007
18	Sibling cases of Vici syndrome: sleep abnormalities and complications of renal tubular acidosis. (17163544)	Miyata R.... Kohyama J.	2007
19	Complete renal tubular acidosis late after kidney transplantation. (16644772)	Schwarz C.... HAAS M.	2006
20	Proximal renal tubular acidosis. (16736440)	Quigley R.	2006
21	The human NBCe1-A mutant R881C, associated with proximal renal tubular acidosis, retains function but is mistargeted in polarized renal epithelia. (16707554)	Toye A.M.... Boron W.F.	2006
22	Medullary sponge kidney associated with distal renal tubular acidosis in a 5-year-old girl. (16602004)	Kasap B.... KavukAsu S.	2006
23	Autoantibodies against carbonic anhydrase II are increased in renal tubular acidosis associated with Sjogren syndrome. (15694905)	Takemoto F.... Uchida S.	2005
24	Comparison of growth in primary Fanconi syndrome and proximal renal tubular acidosis. (15703948)	Hsu S.Y.... Tsau Y.K.	2005
25	Coeliac disease associated with SjAPgren's syndrome, renal tubular acidosis, primary biliary cirrhosis and autoimmune hyperthyroidism. (15285530)	Fracchia M.... Bertero M.T.	2004
26	Distal renal tubular acidosis in mice that lack the forkhead transcription factor Foxi1. (15173882)	Blomqvist S.R.... EnerbAock S.	2004
27	Hypercalcemia and distal renal tubular acidosis: an association not only in the newborn. (12820054)	Pela I.... Materassi M.	2003
28	Hyperoxaluria in patients with primary distal renal tubular acidosis. (12728365)	Mehler K.... Hoppe B.	2003
29	Band 3 mutations, distal renal tubular acidosis, and Southeast Asian ovalocytosis. (12081559)	Wrong O.... Tanner M.J.	2002
30	Recurrent life-threatening acidosis induced by acetazolamide in a patient with diabetic type IV renal tubular acidosis. (12140510)	Elinav E.... Heyman S.N.	2002
31	Hereditary distal renal tubular acidosis: new understandings. (11160790)	Batlle D.... Mitra A.	2001
32	Renal tubular acidosis in horses (1980-1999). (11300597)	Aleman M.R.... Carlson G.P.	2001
33	Renal tubular acidosis syndromes. (11095551)	Kurtzman N.A.	2000
34	Renal tubular acidosis associated with zonisamide therapy. (11114225)	Inoue T.... Hara T.	2000
35	Renal tubular acidosis and osteopetrosis. (10229010)	Donckerwolcke R.... Stone P.	1999
36	Successful renal transplantation in 3 family members with type 1 renal tubular acidosis. (10524897)	Kidd C.F.... Barry J.M.	1999
37	FK506 "rescue" therapy complicated by renal tubular acidosis in renal allograft recipients. (9838575)	Goh B.L.... Tan S.Y.	1998
38	Dimercaptosuccinic acid distribution in renal tubular acidosis. (9505851)	Green D.A.... Davies S.G.	1997
39	Thyrotoxicosis and renal tubular acidosis presenting as hypokalaemic paralysis. (8620307)	Szeto C.C.... Cockram C.S.	1996
40	Distal renal tubular acidosis and hypokalemic paralysis--genetic and precipitating factors. (9251363)	Koul P.A.... Bhat D.	1996
41	Distal renal tubular acidosis associated with non-autoimmune hypothyroidism. (8671985)	Fang J.T.... Huang C.C.	1996
42	Newborn renal tubular acidosis associated with prenatal maternal toluene sniffing. (8811588)	Erramouspe J.... Fischel D.R.	1996
43	Familial cryptogenic fibrosing pleuritis with Fanconi's syndrome (renal tubular acidosis). A new syndrome. (7842801)	Hayes J.P.... Fitzgerald M.X.	1995
44	Vanadate causes hypokalemic distal renal tubular acidosis. (1313645)	Dafnis E.... Sabatini S.	1992
45	Hypocitraturic and hypercalciuric renal tubular acidosis with nephrocalcinosis in a 4-year-old boy. (2127591)	Kluka V.	1990
46	Pseudohypoaldosteronism type II: proximal renal tubular acidosis and dDAVP-sensitive renal hyperkalemia. (3777034)	Nahum H.... Idatte J.M.	1986
47	Carbonic anhydrase II deficiency in 12 families with the autosomal recessive syndrome of osteopetrosis with renal tubular acidosis and cerebral calcification. (3925334)	Sly W.S.... Al-Mosawi M.	1985
48	Idiopathic hypergammaglobulinaemia associated with nephrogenic diabetes insipidus and distal renal tubular acidosis. (6463004)	Spruce B.A.... Morley A.R.	1984
49	Osteosclerosis in renal tubular acidosis: a case report. (617605)	Chin W.S.... Cheah J.S.	1977
50	Fanconi syndrome with renal tubular acidosis and light chain proteinuria. (5155597)	Walker B.R.... Tannenbaum P.J.	1971

Genes related to Renal Tubular Acidosis

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Renal Tubular Acidosis:

(show top 50) (show all 60)

id	Symbol	Description	Score	Implication
1	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	20.23	GeneCards inferred : Publications, Disorders, Gene name, Summaries (show sections)
2	SLC4A1	solute carrier family 4 (anion exchanger), member 1	19.89	GeneCards inferred : Publications, Disorders, Summaries (show sections)
3	ATP6V0A4	ATPase, H+ transporting, lysosomal V0 subunit a4	19.55	GeneCards inferred : Publications, Disorders, Summaries (show sections)
4	CA2	carbonic anhydrase II	19.21	GeneCards inferred : Publications, Disorders, Summaries (show sections)
5	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	18.88	GeneCards inferred : Publications, Disorders, Summaries (show sections)
6	SLC26A1	solute carrier family 26 (anion exchanger), member 1	18.50	GeneCards inferred : Publications, Disorders (show sections)
7	MT-ATP6	mitochondrially encoded ATP synthase 6	18.17	GeneCards inferred : Publications, Disorders (show sections)
8	MT-CO3	mitochondrially encoded cytochrome c oxidase III	17.84	GeneCards inferred : Disorders (show sections)
9	CA4	carbonic anhydrase IV	17.50	GeneCards inferred : Publications, Disorders (show sections)
10	TCIRG1	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	17.17	GeneCards inferred : Publications, Disorders (show sections)
11	SLC26A6	solute carrier family 26 (anion exchanger), member 6	16.84	GeneCards inferred : Publications, Disorders (show sections)
12	SCNN1G	sodium channel, non-voltage-gated 1, gamma subunit	16.50	GeneCards inferred : Publications, Disorders (show sections)
13	AMBP	alpha-1-microglobulin/bikunin precursor	16.18	GeneCards inferred : Disorders (show sections)
14	DNAH8	dynein, axonemal, heavy chain 8	15.84	GeneCards inferred : Publications, Disorders (show sections)
15	SLC4A2	solute carrier family 4 (anion exchanger), member 2	15.50	GeneCards inferred : Publications, Disorders (show sections)
16	CA14	carbonic anhydrase XIV	15.17	GeneCards inferred : Publications, Disorders (show sections)
17	ATP6AP1	ATPase, H+ transporting, lysosomal accessory protein 1	14.84	GeneCards inferred : Publications, Disorders (show sections)
18	ATP6V1G3	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3	14.50	GeneCards inferred : Publications, Disorders (show sections)
19	ATP6V1G2	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2	14.17	GeneCards inferred : Publications, Disorders (show sections)
20	ATP6V0D1	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1	13.84	GeneCards inferred : Publications, Disorders (show sections)
21	ATP6V1G1	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	13.50	GeneCards inferred : Publications, Disorders (show sections)
22	ATP6V0D2	ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2	13.17	GeneCards inferred : Publications, Disorders (show sections)
23	SLC4A1AP	solute carrier family 4 (anion exchanger), member 1, adaptor protein	12.84	GeneCards inferred : Publications, Disorders (show sections)
24	FXYD2	FXYD domain containing ion transport regulator 2	12.50	GeneCards inferred : Disorders (show sections)
25	OSGEP	O-sialoglycoprotein endopeptidase	12.17	GeneCards inferred : Disorders (show sections)
26	FOXI1	forkhead box I1	11.84	GeneCards inferred : Disorders (show sections)
27	ATP4A	ATPase, H+/K+ exchanging, alpha polypeptide	11.50	GeneCards inferred : Disorders (show sections)
28	SLC12A7	solute carrier family 12 (potassium/chloride transporter), member 7	11.17	GeneCards inferred : Publications, Disorders (show sections)
29	ATP6V1C1	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1	10.84	GeneCards inferred : Publications, Disorders (show sections)
30	ATP6V1C2	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	10.50	GeneCards inferred : Publications, Disorders (show sections)
31	SLC9A3	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	10.17	GeneCards inferred : Publications, Disorders (show sections)
32	SLC9A2	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	9.84	GeneCards inferred : Publications, Disorders (show sections)
33	SLC9A8	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	9.50	GeneCards inferred : Publications, Disorders (show sections)
34	ATP6V0E1	ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1	9.17	GeneCards inferred : Publications, Disorders (show sections)
35	HSPG2	heparan sulfate proteoglycan 2	8.84	GeneCards inferred : Publications, Disorders (show sections)
36	OCRL	oculocerebrorenal syndrome of Lowe	8.50	GeneCards inferred : Disorders (show sections)
37	ATP12A	ATPase, H+/K+ transporting, nongastric, alpha polypeptide	8.17	GeneCards inferred : Disorders (show sections)
38	RHCG	Rh family, C glycoprotein	7.84	GeneCards inferred : Disorders (show sections)
39	CPT1A	carnitine palmitoyltransferase 1A (liver)	7.50	GeneCards inferred : Publications, Disorders (show sections)
40	GAD2	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)	7.17	GeneCards inferred : Publications, Disorders (show sections)
41	SLC4A7	solute carrier family 4, sodium bicarbonate cotransporter, member 7	6.84	GeneCards inferred : Publications, Disorders (show sections)
42	ATP6V1B2	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	6.50	GeneCards inferred : Disorders (show sections)
43	ATP6V0A1	ATPase, H+ transporting, lysosomal V0 subunit a1	6.17	GeneCards inferred : Disorders (show sections)
44	PTH	parathyroid hormone	5.84	GeneCards inferred : Disorders (show sections)
45	ATP6V0A2	ATPase, H+ transporting, lysosomal V0 subunit a2	5.50	GeneCards inferred : Disorders (show sections)
46	CLCN5	chloride channel, voltage-sensitive 5	5.17	GeneCards inferred : Disorders (show sections)
47	UMOD	uromodulin	4.84	GeneCards inferred : Disorders (show sections)
48	AP1M1	adaptor-related protein complex 1, mu 1 subunit	4.50	GeneCards inferred : Disorders (show sections)
49	SLC26A4	solute carrier family 26 (anion exchanger), member 4	4.17	GeneCards inferred : Disorders (show sections)
50	MAP1LC3B	microtubule-associated protein 1 light chain 3 beta	3.84	GeneCards inferred : Disorders (show sections)

Products for genes related to Renal Tubular Acidosis disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	45	45	48
2	LSBio	-	-	50

Genetic Variations for Renal Tubular Acidosis

Expression for genes affiliated with Renal Tubular Acidosis

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Renal Tubular Acidosis

Search GEO for disease gene expression data for Renal Tubular Acidosis.

Pathways for genes affiliated with Renal Tubular Acidosis

Sources:
⁵³Reactome, ²⁹KEGG, ³⁷NCBI BioSystems Database
See all sources

Pathways related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 19)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Multifunctional anion exchangers⁵³	10.3	SLC26A6, SLC26A1
2	O2/CO2 exchange in erythrocytes⁵³ Hide members Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes⁵³ Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes⁵³	10.3	CA4, SLC4A1, CA2
3	Proximal tubule bicarbonate reclamation²⁹	10.3	SLC4A4, CA4, CA2
4	Bicarbonate transporters⁵³	10.3	SLC4A1, SLC4A2, SLC4A4
5	Pancreatic secretion²⁹	10.3	SLC4A4, SLC4A2, CA2
6	Bile secretion²⁹	10.3	SLC4A2, CA2, SLC4A4
7	Reversible Hydration of Carbon Dioxide⁵³ Hide members Nitrogen metabolism²⁹	10.3	CA14, CA2, CA4
8	Lysosome²⁹	10.2	TCIRG1, ATP6AP1, ATP6V0A4, ATP6V0D1
9	Tuberculosis²⁹	10.2	ATP6V0D1, ATP6V0A4, TCIRG1, ATP6AP1
10	Amino acid and oligopeptide SLC transporters⁵³ Hide members Transport of inorganic cations/anions and amino acids/oligopeptides⁵³	10.2	SLC4A4, SLC4A1, SLC4A2, SLC26A6, SLC26A1
11	Synaptic vesicle cycle²⁹	10.0	ATP6V0D1, ATP6V0A4, ATP6V1G3, ATP6V1G2, ATP6V1B1, TCIRG1
12	IRS-related events⁵³ Hide members Signaling by Insulin receptor⁵³	10.0	ATP6V0D1, ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V1B1, TCIRG1
13	Disease⁵³	10.0	ATP6V1G3, ATP6V1G2, ATP6V1B1, ATP6V0D1, SLC26A1, TCIRG1
14	Rheumatoid arthritis²⁹	9.9	ATP6V1G2, ATP6AP1, ATP6V1G3, ATP6V0A4, ATP6V0D1, ATP6V1B1
15	Phagosome²⁹	9.9	TCIRG1, ATP6V1G3, ATP6AP1, ATP6V0A4, ATP6V1G2, ATP6V0D1
16	Insulin receptor recycling⁵³ Hide members Vibrio cholerae infection²⁹ Transferrin endocytosis and recycling⁵³ Phagosomal maturation (early endosomal stage)⁵³ Epithelial cell signaling in Helicobacter pylori infection²⁹ Iron uptake and transport⁵³ Latent infection of Homo sapiens with Mycobacterium tuberculosis⁵³ Collecting duct acid secretion²⁹	9.8	ATP6AP1, ATP6V1G2, ATP6V0A4, ATP6V1G3, CA2, ATP6V0D1
17	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.⁵³ Hide members Oxidative phosphorylation²⁹ Alzheimers disease²⁹ The citric acid (TCA) cycle and respiratory electron transport⁵³ Respiratory electron transport⁵³ Electron Transport Chain³⁷ Non-alcoholic fatty liver disease (NAFLD)²⁹ Huntingtons disease²⁹ Parkinsons disease²⁹ Oxidative phosphorylation³⁷	9.8	ATP6AP1, ATP6V1G2, TCIRG1, MT-CO3, MT-ATP6, ATP6V1B1
18	Metabolism⁵³ Hide members Metabolic pathways²⁹	9.7	ATP6V1B1, MT-ATP6, CA14, CA2, CA4, ATP6AP1
19	SLC-mediated transmembrane transport⁵³ Hide members Transmembrane transport of small molecules⁵³	9.6	ATP6V0D1, SCNN1G, ATP6V1G3, ATP6V0A4, ATP6V1B1, SLC4A2

Compounds for genes affiliated with Renal Tubular Acidosis

Sources:
¹¹DrugBank, ⁵⁹Tocris Bioscience, ⁴⁴Novoseek, ²⁸IUPHAR, ²⁴HMDB
See all sources

Compounds related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 40)

id	Compound	Score	Top Affiliating Genes
1	Methyclothiazide¹¹	10.7	CA2, CA4
2	u 104⁵⁹	10.7	CA2, CA4
3	ethoxzolamide⁴⁴ ¹¹	11.7	SLC4A4, CA4, CA2
4	chlorothiazide²⁸ ¹¹	11.7	CA4, CA2
5	stilbene⁴⁴	10.7	SLC4A2, SLC4A1
6	sodium bicarbonate⁴⁴ ¹¹	11.7	SLC4A4, CA4, CA2
7	dids⁴⁴ ²⁸	11.7	SLC4A1, SLC4A2, SLC4A4
8	Benzthiazide¹¹	10.7	CA2, CA4
9	Trichlormethiazide¹¹	10.7	CA2, CA4
10	dorzolamide⁴⁴ ¹¹	11.7	CA2, CA4
11	ellagic acid⁴⁴ ⁵⁹ ¹¹	12.7	CA14, CA2, CA4
12	sulfonamide⁴⁴	10.6	CA14, CA2, CA4
13	brinzolamide⁴⁴ ¹¹	11.6	CA2, CA4
14	dichlorphenamide⁴⁴ ¹¹	11.6	CA2, CA4
15	zonisamide⁴⁴ ¹¹	11.6	CA4, CA2, CA14
16	acetazolamide⁴⁴ ¹¹	11.6	CA14, CA2, CA4, SLC4A4
17	bendroflumethiazide⁴⁴ ¹¹	11.6	CA2, CA4
18	Hydroflumethiazide¹¹	10.6	CA4, CA2
19	sulfate⁴⁴ ²⁴	11.6	AMBP, SLC4A1, SLC4A2, SLC26A1
20	naoh⁴⁴	10.6	SLC4A1, AMBP
21	methazolamide⁴⁴ ¹¹	11.6	CA2, CA4
22	amiloride⁴⁴ ²⁸ ¹¹	12.5	SLC4A2, SCNN1G, CA2
23	cyclothiazide²⁸ ⁴⁴ ¹¹	12.5	CA4, CA2
24	disulfiram⁴⁴ ⁵⁹ ¹¹	12.5	ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1
25	chloride⁴⁴	10.5	CA2, CA4, SLC4A1, SLC4A2, SLC26A1, SLC4A4
26	hydrogen⁴⁴ ²⁴	11.5	CA2, CA4, MT-ATP6, DNAH8, SLC4A1
27	oxalate⁴⁴	10.5	SLC26A1, SLC4A1
28	sodium⁴⁴ ²⁴	11.5	AMBP, CA4, SCNN1G, SLC4A1, SLC4A2, SLC4A4
29	concanamycin a⁴⁴ ⁵⁹	11.4	ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1, DNAH8
30	bafilomycin a1⁴⁴ ⁵⁹ ¹¹	12.4	ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1, DNAH8
31	carbon dioxide⁴⁴ ²⁴	11.4	CA14, CA2, CA4
32	atp⁴⁴ ²⁸	11.4	CA2, ATP6AP1, MT-ATP6, MT-CO3, DNAH8, SLC4A1
33	bicarbonate⁴⁴	10.4	SLC4A4, CA14, CA2, CA4, ATP6AP1, SLC4A1
34	sodium dodecylsulfate⁴⁴	10.3	CA4, CA2, AMBP
35	oligomycin⁴⁴	10.3	DNAH8, MT-ATP6
36	Adenosine triphosphate¹¹ ²⁴	11.3	ATP6AP1, ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1
37	citrate⁴⁴	10.3	SLC4A1, MT-CO3, CA2
38	topiramate⁴⁴ ¹¹ ²⁴	12.3	CA2, CA4
39	adp⁴⁴ ²⁸ ²⁴	12.2	ATP6AP1, ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1
40	potassium⁴⁴ ¹¹ ²⁴	11.9	SLC4A4, SLC4A1, ATP6AP1, AMBP

GO Terms for genes affiliated with Renal Tubular Acidosis

Sources:
¹⁶Gene Ontology
See all sources

Cellular components related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proton-transporting V-type ATPase, V1 domain	GO:033180	10.3	ATP6V1B1, ATP6AP1
2	brush border membrane	GO:031526	10.3	ATP6V0A4, CA4, SLC26A6
3	vacuolar proton-transporting V-type ATPase complex	GO:016471	10.3	ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1
4	vacuolar proton-transporting V-type ATPase, V0 domain	GO:000220	10.3	TCIRG1, ATP6V0A4
5	basolateral plasma membrane	GO:016323	10.2	SLC4A4, SLC26A6, SLC4A2, SLC4A1, CA4, ATP6V1B1
6	apical plasma membrane	GO:016324	10.1	SLC26A6, TCIRG1, ATP6V0D1, ATP6V0A4, SCNN1G, CA4
7	phagocytic vesicle membrane	GO:030670	10.0	ATP6V0A4, ATP6V0D1, TCIRG1
8	plasma membrane	GO:005886	9.7	SLC26A6, AMBP, SCNN1G, TCIRG1, SLC4A4, SLC26A1

Biological processes related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of dipeptide transmembrane transport	GO:2001150	10.5	CA2, SLC26A6
2	angiotensin-mediated signaling pathway	GO:038166	10.5	SLC26A6, CA2
3	chloride transport	GO:006821	10.5	SLC4A1, SLC26A6, SLC26A1
4	oxalate transport	GO:019532	10.4	SLC26A1, SLC26A6
5	excretion	GO:007588	10.4	ATP6V0A4, ATP6V1B1, SCNN1G
6	proton transport	GO:015992	10.4	ATP6V0D1, ATP6V0A4, ATP6AP1, TCIRG1, ATP6V1B1
7	ATP hydrolysis coupled proton transport	GO:015991	10.4	TCIRG1, ATP6V1B1, ATP6V0D1, ATP6V0A4, ATP6AP1
8	ion transport	GO:006811	10.4	SLC26A6, SLC4A1, SLC4A4, SLC26A1, SLC4A2
9	regulation of pH	GO:006885	10.4	ATP6V1B1, ATP6V0A4
10	regulation of intracellular pH	GO:051453	10.4	CA2, SLC26A6
11	transferrin transport	GO:033572	10.3	ATP6V0A4, TCIRG1, ATP6V1B1, ATP6V0D1, ATP6V1G2, ATP6V1G3
12	interaction with host	GO:051701	10.3	ATP6V1G3, TCIRG1, ATP6V1B1, ATP6V1G2, ATP6V0A4, ATP6V0D1
13	bicarbonate transport	GO:015701	10.3	SLC26A6, CA14, CA2, CA4, SLC4A1, SLC4A2
14	phagosome maturation	GO:090382	10.3	ATP6V0A4, ATP6V1G2, ATP6V0D1, TCIRG1, ATP6V1G3, ATP6V1B1
15	cellular iron ion homeostasis	GO:006879	10.3	TCIRG1, ATP6V1B1, ATP6V1G3, ATP6V0A4, ATP6V1G2, ATP6V0D1
16	insulin receptor signaling pathway	GO:008286	10.3	ATP6V0A4, ATP6V1G2, ATP6V0D1, ATP6V1B1, TCIRG1, ATP6V1G3
17	anion transport	GO:006820	10.2	SLC4A1, SLC4A2
18	sulfate transport	GO:008272	10.0	SLC26A1, SLC26A6
19	transmembrane transport	GO:055085	10.0	SCNN1G, ATP6V0A4, TCIRG1, SLC26A6, SLC4A4, SLC26A1

Molecular functions related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	anion:anion antiporter activity	GO:015301	10.5	SLC26A1, SLC26A6, SLC4A1
2	chloride transmembrane transporter activity	GO:015108	10.4	SLC26A1, SLC26A6, SLC4A2, SLC4A1
3	inorganic anion exchanger activity	GO:005452	10.4	SLC4A1, SLC4A2, SLC4A4
4	hydrogen-exporting ATPase activity, phosphorylative mechanism	GO:008553	10.4	ATP6V1G3, ATP6V1G2, ATP6V0D1
5	carbonate dehydratase activity	GO:004089	10.4	CA14, CA2, CA4
6	hydrogen ion transmembrane transporter activity	GO:015078	10.4	ATP6V0A4, ATP6V1B1, TCIRG1
7	oxalate transmembrane transporter activity	GO:019531	10.3	SLC26A1, SLC26A6
8	secondary active sulfate transmembrane transporter activity	GO:008271	10.3	SLC26A6, SLC26A1
9	anion transmembrane transporter activity	GO:008509	10.2	SLC4A2, SLC4A1
10	sulfate transmembrane transporter activity	GO:015116	10.0	SLC26A1, SLC26A6