Renal Tubular Acidosis disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Renal Tubular Acidosis

Sources:
⁶⁴Wikipedia, ³²MalaCards
See all sources

Wikipedia:⁶⁴ Renal tubular acidosis (RTA) is a medical condition that involves an accumulation of acid in the body... more...

MalaCards based summary: Renal Tubular Acidosis, also known as acidosis renal tubular, is related to nephrocalcinosis and sensorineural hearing loss. An important gene associated with Renal Tubular Acidosis is ATP6V1B1 (ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1), and among its related pathways are Insulin receptor signalling cascade and Phagosome. The drugs citric acid and sodium bicarbonate and the compounds concanamycin a and bafilomycin a1 have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and liver, and related mouse phenotypes are taste/olfaction and skeleton.

Aliases & Classifications for Renal Tubular Acidosis

Sources:
³¹LifeMap Discovery®, ⁹Disease Ontology, ⁴²NIH Rare Diseases, ¹¹DISEASES, ⁶¹UMLS, ⁴⁴Novoseek, ³⁴MeSH, ⁵⁶SNOMED-CT, ³⁹NCIt
See all sources

Renal Tubular Acidosis, Aliases & Descriptions:

Name: Renal Tubular Acidosis ³¹ ⁹ ⁴² ¹¹ ⁶¹

Acidosis Renal Tubular ⁴⁴

Renal Tubule Acidosis ⁹

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Nephrological diseases

External Ids:

Disease Ontology⁹ DOID:14219

MeSH³⁴ D000141

SNOMED-CT⁵⁶ 1776003

NCIt³⁹ C28129

UMLS⁶¹ C0001126

Related Diseases for Renal Tubular Acidosis

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases related to Renal Tubular Acidosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50) (show all 140)

id	Related Disease	Score	Top Affiliating Genes
1	nephrocalcinosis	31.0	ATP6V1B1, ATP6V0A4, CA2, SLC4A1
2	sensorineural hearing loss	31.0	ATP6V0A4, ATP6V1B1
3	renal tubular acidosis, distal, autosomal recessive	30.8	SLC4A1, ATP6V0A4, ATP6V1B1
4	renal tubular acidosis, distal	30.5	ATP6V1B1, ATP6V0A4, CA2, SLC4A1
5	metabolic acidosis	29.9	ATP6V1B1, ATP6V0A4, CA2, SLC4A4, SLC4A1
6	renal tubular acidosis with progressive nerve deafness	11.0
7	osteopetrosis	10.8
8	osteomalacia	10.7
9	slc4a1-associated distal renal tubular acidosis	10.7
10	diabetes insipidus	10.7
11	primary biliary cirrhosis	10.7
12	nephrogenic diabetes insipidus	10.7
13	proximal renal tubular acidosis with ocular abnormalities	10.7
14	systemic lupus erythematosus	10.7
15	hypokalemic periodic paralysis	10.7
16	lupus erythematosus	10.7
17	renal tubular acidosis, distal, autosomal dominant	10.7
18	fanconi syndrome	10.6
19	cerebritis	10.6
20	renal tubular acidosis, distal, ad	10.6
21	medullary sponge kidney	10.6
22	osteopetrosis, autosomal recessive 3, with renal tubular acidosis	10.6
23	nephritis	10.6
24	sjogren's syndrome	10.6
25	hyperparathyroidism	10.6
26	neuroaxonal dystrophy renal tubular acidosis	10.6
27	hypothyroidism	10.5
28	respiratory failure	10.5
29	renal tubular acidosis, distal, type 3	10.5
30	diabetes mellitus	10.5
31	nephrolithiasis	10.5
32	osteoporosis	10.5
33	hypercalcemia	10.5
34	thyroiditis	10.5
35	osteopetrosis autosomal recessive 3	10.5
36	erythrocytosis	10.5
37	autosomal recessive distal renal tubular acidosis without deafness	10.5
38	arthritis	10.4
39	hepatitis	10.4
40	cystinosis	10.4
41	hereditary spherocytosis	10.4
42	rickets	10.4
43	hyperthyroidism	10.4
44	renal tubular acidosis, distal, with hemolytic anemia	10.4
45	renal tubular acidosis, distal, ar	10.4
46	amelogenesis imperfecta	10.3
47	hemolytic anemia	10.3
48	rheumatoid arthritis	10.3
49	type 1 diabetes mellitus	10.3
50	hereditary elliptocytosis	10.3

Graphical network of the top 20 diseases related to Renal Tubular Acidosis:

Symptoms for Renal Tubular Acidosis

Drugs & Therapeutics for Renal Tubular Acidosis

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials, ⁶¹UMLS, ⁴⁰NDF-RT
See all sources

Drug clinical trials:

Search ClinicalTrials for Renal Tubular Acidosis

Search NIH Clinical Center for Renal Tubular Acidosis

Inferred drug relations via UMLS⁶¹/NDF-RT⁴⁰:

Show with subtypes

citric acid

citric acid, anhydrous

citric acid,hydrous

citric acid granules

citric acid monohydrate

citrus naringinine

sodium bicarbonate

sodium bicarbonate powder

Genetic Tests for Renal Tubular Acidosis

Anatomical Context for Renal Tubular Acidosis

Sources:
³¹LifeMap Discovery®, ³²MalaCards
See all sources

MalaCards organs/tissues related to Renal Tubular Acidosis:

³²

Kidney, Bone, Liver, Thyroid, Brain, Colon, Heart, Lung, Testes, Neutrophil

The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Renal Tubular Acidosis:

id	TissueAnatomical CompartmentCell	Relevance
1	KidneyProximal TubuleProximal Tubule Cells	Potential therapeutic candidate, affected by disease

Animal Models for Renal Tubular Acidosis or affiliated genes

Sources:
³⁶MGI
See all sources

MGI Mouse Phenotypes related to Renal Tubular Acidosis:

³⁶

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	taste/olfaction phenotype	MP:0005394	9.6	ATP6V0A4, ATP6V1B1
2	skeleton phenotype	MP:0005390	8.2	SLC4A4, CA2, ATP6V0A4, ATP6V1B1
3	renal/urinary system phenotype	MP:0005367	7.3	SLC4A1, SLC4A4, SLC26A1, CA2, ATP6V0A4, ATP6V1B1
4	homeostasis/metabolism phenotype	MP:0005376	7.2	ATP6V1B1, ATP6V0A4, CA2, SLC26A1, SLC4A4, SLC4A1

Publications for Renal Tubular Acidosis

Sources:
⁵¹PubMed
See all sources

Articles related to Renal Tubular Acidosis:

(show top 50) (show all 570)

id	Title	Authors	Year
1	Central neurogenic hyperventilation and renal tubular acidosis in children with pontine gliomas. (24532275)	Ledet D.... Broniscer A.	2014
2	ATP6V1B1 mutations in distal renal tubular acidosis and sensorineural hearing loss: clinical and genetic spectrum of five families. (23923981)	Subasioglu Uzak A.... Tekin M.	2013
3	Basic research: Salt wasting in distal renal tubular acidosis-new look, old problem. (24189652)	Al-Awqati Q.	2013
4	Distal renal tubular acidosis: a hereditary disease with an inadequate urinary Ha8_ excretion. (23640117)	Escobar L.... Santos F.	2013
5	Erratum to "Endolymphatic Sac Enlargement in a Girl with a Novel Mutation for Distal Renal Tubular Acidosis and Severe Deafness" (23691405)	Rink N.... Goodyer P.	2013
6	Distal renal tubular acidosis associated with non-autoimmune hypothyroidism. (22805408)	Laway B.A.... Wani I.A.	2012
7	Type 1 renal tubular acidosis in a patient of Type 1 diabetes mellitus: Is it coincidence or coexistence? (22701829)	Naik M.... Shah Y.	2012
8	Genetic causes and mechanisms of distal renal tubular acidosis. (23114896)	Batlle D.... Haque S.K.	2012
9	Hypokalaemic paralysis with seemingly pH-neutralized blood gas: liquorice-induced mineralocorticoid effect superimposed on renal tubular acidosis. (22145284)	Chen C.F.... Lin C.C.	2011
10	Distal renal tubular acidosis (dRTA) and bone histomorphometry. (21799506)	Arampatzis S.... Stefanidis I.	2011
11	Life-threatening hypokalaemia associated with ibuprofen-induced renal tubular acidosis. (21426288)	Ng J.L.... Prentice D.	2011
12	Systemic lupus erythematosus associated with type 4 renal tubular acidosis: a case report and review of the literature. (21435204)	Porteous H.... Lenz O.	2011
13	Renal tubular acidosis due to Wilson's disease presenting as metabolic bone disease. (22688476)	Palkar A.V.... Moulick N.	2011
14	Hyperkalemic distal renal tubular acidosis caused by immunosuppressant treatment with tacrolimus in a liver transplant patient: case report. (22172892)	Riveiro-Barciela M.... Castells L.	2011
15	Novel compound heterozygous ATP6V0A4 mutations in an infant with distal renal tubular acidosis. (20221774)	Saito T.... Kamoda T.	2010
16	Band 3 Edmonton I, a novel mutant of the anion exchanger 1 causing spherocytosis and distal renal tubular acidosis. (20028337)	Chu C.... Cordat E.	2010
17	Renal tubular acidosis and superior mesenteric artery syndrome. (22752559)	Agrawal S.... Chaube R.	2010
18	Medullary sponge kidney associated with primary distal renal tubular acidosis and mutations of the H+-ATPase genes. (19364879)	Carboni I.... Giglio S.	2009
19	Severe hypophosphatemic osteomalacia with Fanconi syndrome, renal tubular acidosis, vitamin D deficiency and primary biliary cirrhosis. (19252361)	Bando H.... Kaji H.	2009
20	Distal renal tubular acidosis and immune-mediated hemolytic anemia in 3 dogs. (19909430)	Shearer L.R.... Holowaychuk M.K.	2009
21	HDR syndrome (hypoparathyroidism, sensorineural deafness and renal disease) accompanied by renal tubular acidosis and endocrine abnormalities. (18520110)	Taslipinar A.... Ibrahim Aydin H.	2008
22	Type 1 (distal) renal tubular acidosis in a patient with Type 1 diabetes mellitus--not all cases of metabolic acidosis in Type 1 diabetes mellitus are due to diabetic ketoacidosis. (18199141)	Dymot J.A.... McKay G.A.	2008
23	Distal renal tubular acidosis associated with anion exchanger 1 mutations in children in Thailand. (17533027)	Khositseth S.... Yenchitsomanus P.T.	2007
24	Combined renal tubular acidosis and diabetes insipidus in hematological disease. (17322929)	Hoorn E.J.... Zietse R.	2007
25	Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1). (16636648)	Demirci F.Y.... Gorin M.B.	2006
26	Pemetrexed-induced acute renal failure, nephrogenic diabetes insipidus, and renal tubular acidosis in a patient with non-small cell lung cancer. (17018900)	Vootukuru V.... Nally J.V.	2006
27	Type 1 renal tubular acidosis in a broodmare. (16627119)	Gull T.	2006
28	Secondary erythrocytosis associated with distal renal tubular acidosis. (15571188)	Matsukura H.... Izumino K.	2004
29	Coeliac disease associated with SjAPgren's syndrome, renal tubular acidosis, primary biliary cirrhosis and autoimmune hyperthyroidism. (15285530)	Fracchia M.... Bertero M.T.	2004
30	Renal tubular acidosis: a new look at an old problem. (11681819)	Roth K.S.... Chan J.C.	2001
31	Hereditary distal renal tubular acidosis: new understandings. (11160790)	Batlle D.... Mitra A.	2001
32	Bone mineral density and histology in distal renal tubular acidosis. (11231364)	Domrongkitchaiporn S.... Rajatanavin R.	2001
33	Hypercalcemia in neonatal distal renal tubular acidosis. (10775085)	RodrA-guez-Soriano J.... AlvA!rez-Granda J.L.	2000
34	A case of hyperkalemic distal renal tubular acidosis secondary to tacrolimus in living donor liver transplantation. (11120143)	Oishi M.... Tanaka N.	2000
35	Incomplete renal tubular acidosis in 'primary' osteoporosis. (11095178)	SA!nchez A.... Libman J.	2000
36	Distal renal tubular acidosis and high urine carbon dioxide tension in a patient with southeast Asian ovalocytosis. (10352205)	Kaitwatcharachai C.... Nimmannit S.	1999
37	Type IV renal tubular acidosis and uric acid nephrolithiasis in William's syndrome--an unusual mode of renal involvement. (9249793)	De Ferrari M.E.... Civati G.	1997
38	A novel neurological disorder with progressive CNS calcification, deafness, renal tubular acidosis, and microcytic anemia. (9112970)	Yoshimura M.... Takeshita K.	1997
39	Dimercaptosuccinic acid distribution in renal tubular acidosis. (9505851)	Green D.A.... Davies S.G.	1997
40	Renal tubular acidosis with muscle paralysis. (9529855)	Nagaria A.M.... Khan J.A.	1997
41	Prevalence of endemic distal renal tubular acidosis and renal stone in the northeast of Thailand. (8730429)	Nimmannit S.... Nilwarangkur S.	1996
42	The spectrum of endemic renal tubular acidosis in the northeast of Thailand. (8938678)	Vasuvattakul S.... Nilwarangkur S.	1996
43	Renal tubular acidosis in children with vesicoureteral reflux. (8648800)	Guizar J.M.... Zamora J.	1996
44	Trimethoprim-sulfamethoxazole-induced renal tubular acidosis in a patient with AIDS. (7620045)	Domingo P.... Ris J.	1995
45	Light-chain-induced renal tubular acidosis: effect of sodium bicarbonate on sodium-proton exchange. (7724027)	Reusch H.P.... Luft F.C.	1995
46	Persistent isolated proximal renal tubular acidosis--a systemic disease with a distinct clinical entity. (8142230)	Igarashi T.... Ohga K.	1994
47	Osteomalacia secondary to renal tubular acidosis in a patient with primary SjAPgren's syndrome. (1764843)	Monte Neto J.T.... Pereira A.B.	1991
48	Type I primary hyperoxaluria associated with type I renal tubular acidosis. (3449474)	Cheng J.H.... Lin C.Y.	1987
49	Lymphoid interstitial pneumonia with associated chronic active hepatitis and renal tubular acidosis. (835885)	Helman C.A.... Benatar S.R.	1977
50	Fanconi syndrome with renal tubular acidosis and light chain proteinuria. (5155597)	Walker B.R.... Tannenbaum P.J.	1971

Genes related to Renal Tubular Acidosis

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Renal Tubular Acidosis:

- Elite gene

id	Symbol	Description	Score	Implication
1	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	21.99	GeneCards inferred via : Disorders, Publications, Gene name, Summaries (show sections)
2	SLC4A1	solute carrier family 4 (anion exchanger), member 1 (Diego blood group)	19.04	GeneCards inferred via : Disorders, Publications, Summaries (show sections)
3	ATP6V0A4	ATPase, H+ transporting, lysosomal V0 subunit a4	16.13	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
4	CA2	carbonic anhydrase II	13.25	GeneCards inferred via : Publications, Disorders, Summaries (show sections)
5	SLC4A4	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	10.40	GeneCards inferred via : Disorders, Publications, Summaries (show sections)
6	SLC26A1	solute carrier family 26 (anion exchanger), member 1	7.17	GeneCards inferred via : Publications (show sections)
7	MT-ATP6	mitochondrially encoded ATP synthase 6	4.31	GeneCards inferred via : Publications (show sections)

Products for genes related to Renal Tubular Acidosis disease:

id	Company	Proteins	Lysates	Antibodies	Kits and Assays
1	Antibodies-online	5	-	7	7
2	Novus Biologicals	5	3	6	-

Variations for Renal Tubular Acidosis

Expression for genes affiliated with Renal Tubular Acidosis

Sources:
²BioGPS, ¹⁶Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Renal Tubular Acidosis

Search GEO for disease gene expression data for Renal Tubular Acidosis.

Pathways for genes affiliated with Renal Tubular Acidosis

Sources:
⁴⁹PathCards, ⁵⁴Reactome, ³⁷NCBI BioSystems Database, ³⁰KEGG
See all sources

Pathways related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 12)

id	Super pathways (with members indented)	Score	Top Affiliating Genes
1	Insulin receptor signalling cascade⁵⁴ Show member pathways mTORC1-mediated signalling⁵⁴ PKB-mediated events⁵⁴ IRS-related events⁵⁴ Inhibition of TSC complex formation by PKB⁵⁴ IRS-mediated signalling⁵⁴ IRS-related events triggered by IGF1R⁵⁴ PDE3B signalling⁵⁴ SHC-mediated signalling⁵⁴ IRS activation⁵⁴ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)⁵⁴ Energy dependent regulation of mTOR by LKB1-AMPK⁵⁴ S6K1-mediated signalling⁵⁴ Release of eIF4E⁵⁴ IGF1R signaling cascade⁵⁴ Regulation of Rheb GTPase activity by AMPK⁵⁴ Signaling by Insulin receptor⁵⁴ SHC-related events⁵⁴ SOS-mediated signalling⁵⁴ S6K1 signalling⁵⁴ TOR signaling³⁷ PI3K Cascade⁵⁴ Regulation of AMPK activity via LKB1⁵⁴ mTOR signalling⁵⁴ SHC activation⁵⁴ SHC-related events triggered by IGF1R⁵⁴ Signal attenuation⁵⁴	9.6	ATP6V0A4, ATP6V1B1
2	Phagosome³⁰	9.6	ATP6V0A4, ATP6V1B1
3	Synaptic vesicle cycle³⁰ Show member pathways Synaptic Vesicle Pathway³⁷	9.6	ATP6V0A4, ATP6V1B1
4	Rheumatoid arthritis³⁰	9.6	ATP6V1B1, ATP6V0A4
5	O2/CO2 exchange in erythrocytes⁵⁴ Show member pathways Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes⁵⁴ Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes⁵⁴	9.5	SLC4A1, CA2
6	Proximal tubule bicarbonate reclamation³⁰ Show member pathways D-Glutamine and D-glutamate metabolism³⁰	9.3	CA2, SLC4A4
7	Bile secretion³⁰	9.3	SLC4A4, CA2
8	Pancreatic secretion³⁰	9.3	SLC4A4, CA2
9	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.⁵⁴ Show member pathways Formation of ATP by chemiosmotic coupling⁵⁴ Oxidative phosphorylation³⁰ The citric acid (TCA) cycle and respiratory electron transport⁵⁴ Respiratory electron transport⁵⁴ Oxidative phosphorylation³⁷ Electron Transport Chain³⁷ Non-alcoholic fatty liver disease (NAFLD)³⁰ Huntington's disease³⁰ Parkinson's disease³⁰	9.1	MT-ATP6, ATP6V0A4, ATP6V1B1
10	Insulin receptor recycling⁵⁴ Show member pathways Vibrio cholerae infection³⁰ Collecting duct acid secretion³⁰ Transferrin endocytosis and recycling⁵⁴ Epithelial cell signaling in Helicobacter pylori infection³⁰ Iron uptake and transport⁵⁴	8.7	SLC4A1, CA2, ATP6V0A4, ATP6V1B1
11	Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds⁵⁴ Show member pathways Sodium/Proton exchangers⁵⁴ Organic anion transport⁵⁴ Proton/oligonucleotide cotransporters⁵⁴ Proton-coupled monocarboxylate transport⁵⁴ Bicarbonate transporters⁵⁴ Rhesus glycoproteins mediate ammonium transport.⁵⁴ Inositol transporters⁵⁴ SLC-mediated transmembrane transport⁵⁴ Organic anion transporters⁵⁴ Transmembrane transport of small molecules⁵⁴ Facilitative Na+-independent glucose transporters⁵⁴ Transport of inorganic cations/anions and amino acids/oligopeptides⁵⁴ Amino acid transport across the plasma membrane⁵⁴ Type II Na+/Pi cotransporters⁵⁴ Sodium-coupled phosphate cotransporters⁵⁴ Proton-coupled neutral amino acid transporters⁵⁴ Sodium/Calcium exchangers⁵⁴ Organic cation transport⁵⁴ Organic cation/anion/zwitterion transport⁵⁴ Na+/Cl- dependent neurotransmitter transporters⁵⁴ Cation-coupled Chloride cotransporters⁵⁴ Class II GLUTs⁵⁴ Sodium-coupled sulphate, di- and tri-carboxylate transporters⁵⁴ Multifunctional anion exchangers⁵⁴ Na+-dependent glucose transporters⁵⁴	7.8	ATP6V1B1, ATP6V0A4, SLC26A1, SLC4A4, SLC4A1
12	Metabolism⁵⁴ Show member pathways Metabolic pathways³⁰ Metabolism of lipids and lipoproteins⁵⁴	7.4	ATP6V1B1, ATP6V0A4, MT-ATP6, CA2, SLC26A1, SLC4A1

Compounds for genes affiliated with Renal Tubular Acidosis

Sources:
⁴⁴Novoseek, ⁶⁰Tocris Bioscience, ¹²DrugBank, ⁵⁰PharmGKB, ²⁹IUPHAR, ²⁵HMDB
See all sources

Compounds related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 19)

id	Compound	Score	Top Affiliating Genes
1	concanamycin a⁴⁴ ⁶⁰	10.9	ATP6V1B1, ATP6V0A4
2	bafilomycin a1⁴⁴ ⁶⁰ ¹²	11.9	ATP6V0A4, ATP6V1B1
3	disulfiram⁴⁴ ⁵⁰ ⁶⁰ ¹²	12.8	ATP6V1B1, ATP6V0A4
4	furosemide⁴⁴ ⁶⁰ ²⁹ ⁵⁰ ²⁵ ¹²	14.8	CA2, SLC4A1
5	dids⁴⁴ ²⁹	10.7	SLC4A1, SLC4A4
6	ethoxzolamide⁴⁴ ¹²	10.6	SLC4A4, CA2
7	acetazolamide⁴⁴ ¹²	10.6	CA2, SLC4A4
8	sodium bicarbonate⁴⁴ ¹²	10.6	SLC4A4, CA2
9	oxalate⁴⁴	9.5	SLC4A1, SLC26A1
10	citrate⁴⁴	9.4	SLC4A1, CA2
11	sulfate⁴⁴ ²⁵	10.3	SLC26A1, SLC4A1
12	Water²⁵	9.2	CA2, ATP6V0A4, ATP6V1B1
13	hydrogen⁴⁴ ²⁵	10.2	SLC4A1, CA2, MT-ATP6
14	lactate⁴⁴	9.1	CA2, SLC4A4, SLC4A1
15	glutamate⁴⁴	8.9	SLC4A1, SLC4A4, CA2
16	adp⁴⁴ ²⁹ ²⁵	10.8	ATP6V1B1, ATP6V0A4, MT-ATP6
17	calcium⁴⁴ ⁵⁰ ²⁵ ¹²	11.5	SLC4A4, CA2, ATP6V0A4, ATP6V1B1
18	bicarbonate⁴⁴	8.4	SLC4A1, SLC4A4, SLC26A1, CA2
19	chloride⁴⁴	8.4	CA2, SLC26A1, SLC4A4, SLC4A1

GO Terms for genes affiliated with Renal Tubular Acidosis

Sources:
¹⁷Gene Ontology
See all sources

Cellular components related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	vacuolar proton-transporting V-type ATPase complex	GO:016471	9.7	ATP6V0A4, ATP6V1B1
2	microvillus	GO:005902	9.5	CA2, ATP6V1B1
3	apical part of cell	GO:045177	9.2	ATP6V0A4, CA2
4	basolateral plasma membrane	GO:016323	8.7	SLC4A1, SLC4A4, CA2, ATP6V1B1
5	extracellular vesicular exosome	GO:070062	8.1	ATP6V1B1, ATP6V0A4, CA2, SLC4A4, SLC4A1
6	plasma membrane	GO:005886	7.6	SLC4A1, SLC4A4, SLC26A1, CA2, ATP6V0A4

Biological processes related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of pH	GO:006885	9.9	ATP6V0A4, ATP6V1B1
2	ATP hydrolysis coupled proton transport	GO:015991	9.9	ATP6V0A4, ATP6V1B1
3	proton transport	GO:015992	9.9	ATP6V0A4, ATP6V1B1
4	transferrin transport	GO:033572	9.9	ATP6V1B1, ATP6V0A4
5	interaction with host	GO:051701	9.8	ATP6V0A4, ATP6V1B1
6	phagosome maturation	GO:090382	9.8	ATP6V1B1, ATP6V0A4
7	excretion	GO:007588	9.8	ATP6V0A4, ATP6V1B1
8	cellular iron ion homeostasis	GO:006879	9.6	ATP6V0A4, ATP6V1B1
9	insulin receptor signaling pathway	GO:008286	9.6	ATP6V0A4, ATP6V1B1
10	ossification	GO:001503	9.5	ATP6V0A4, ATP6V1B1
11	chloride transport	GO:006821	9.4	SLC4A1, SLC26A1
12	sensory perception of sound	GO:007605	9.3	ATP6V0A4, ATP6V1B1
13	chloride transmembrane transport	GO:1902476	9.3	SLC26A1, SLC4A1
14	bicarbonate transport	GO:015701	9.2	SLC4A1, SLC4A4, CA2
15	ion transport	GO:006811	8.9	SLC26A1, SLC4A4, SLC4A1
16	transmembrane transport	GO:055085	8.1	SLC4A1, SLC4A4, SLC26A1, ATP6V0A4, ATP6V1B1

Molecular functions related to Renal Tubular Acidosis according to GeneCards/GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	hydrogen ion transmembrane transporter activity	GO:015078	9.6	ATP6V0A4, ATP6V1B1
2	chloride transmembrane transporter activity	GO:015108	9.2	SLC4A1, SLC26A1
3	anion:anion antiporter activity	GO:015301	9.1	SLC4A1, SLC26A1
4	inorganic anion exchanger activity	GO:005452	9.1	SLC4A1, SLC4A4

Products for genes affiliated with Renal Tubular Acidosis

Antibodies
Proteins
Lysates

Antibodies
Proteins
Kits and Assays

Sources for Renal Tubular Acidosis

¹antibodies-online

²BioGPS

³BitterDB

⁴CDC

⁵Cell Signaling Technology

⁶ClinicalTrials

⁷Clinvar

⁸dbSNP

⁹Disease Ontology

¹⁰diseasecard

¹¹DISEASES

¹²DrugBank

¹³EMD Millipore

¹⁴ExPASy

¹⁵FMA

¹⁶Gene Expression Omnibus DataSets

¹⁷Gene Ontology

¹⁸GeneCards

¹⁹GeneDecks

²⁰GeneReviews

²¹GeneTests

²²Genetics Home Reference

²³GTR

²⁴HGMD

²⁵HMDB

²⁶ICD10

²⁷ICD10 via Orphanet

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MCID: RNL007 MIFTS: 56	Renal Tubular Acidosis malady Rare diseases, Nephrological diseases categories
8 drugs, 7 genes, 11 tissues, 140 related diseases, clinical trials Download this MalaCard Expand all tables

Renal Tubular Acidosis malady