MCID: RNL028
MIFTS: 52

Renal Tubular Dysgenesis malady

Categories: Genetic diseases, Rare diseases, Nephrological diseases, Fetal diseases

Aliases & Classifications for Renal Tubular Dysgenesis

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Aliases & Descriptions for Renal Tubular Dysgenesis:

Name: Renal Tubular Dysgenesis 52 48 25 54 70 12 50
Primitive Renal Tubule Syndrome 48 25 54
Allanson Pantzar Mcleod Syndrome 25 68
 
Rtd 48 70
Renal Tubular Dysgenesis of Genetic Origin 54
Renotubular Dysgenesis 54

Characteristics:

Orphanet epidemiological data:

54
renal tubular dysgenesis:
Inheritance: Autosomal recessive,Not applicable
renal tubular dysgenesis of genetic origin:
Inheritance: Autosomal recessive

HPO:

64
renal tubular dysgenesis:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 267430
UMLS via Orphanet69 C0266313
ICD10 via Orphanet31 Q63.8

Summaries for Renal Tubular Dysgenesis

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Genetics Home Reference:25 Renal tubular dysgenesis is a severe kidney disorder characterized by abnormal development of the kidneys before birth. In particular, kidney structures called proximal tubules are absent or underdeveloped. These structures help to reabsorb needed nutrients, water, and other materials into the blood and excrete everything else into the urine. Without functional proximal tubules, the kidneys cannot produce urine (a condition called anuria).

MalaCards based summary: Renal Tubular Dysgenesis, also known as primitive renal tubule syndrome, is related to renal tubular dysgenesis, ace-related and renal tubular dysgenesis, agt-related, and has symptoms including abnormality of the renal tubule, polycystic kidney dysplasia and hypertelorism. An important gene associated with Renal Tubular Dysgenesis is AGT (Angiotensinogen), and among its related pathways are Peptide hormone metabolism and p70S6K Signaling. Affiliated tissues include kidney, bone and bone marrow, and related mouse phenotypes are adipose tissue and behavior/neurological.

OMIM:52 Autosomal recessive renal tubular dysgenesis is a severe disorder of renal tubular development characterized by... (267430) more...

UniProtKB/Swiss-Prot:70 Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).

Related Diseases for Renal Tubular Dysgenesis

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Diseases in the Renal Tubular Dysgenesis family:

Renal Tubular Dysgenesis, Ace-Related Renal Tubular Dysgenesis, Agt-Related
Renal Tubular Dysgenesis, Agtr1-Related Renal Tubular Dysgenesis, Ren-Related
Renal Tubular Dysgenesis Due to Twin-Twin Transfusion

Diseases related to Renal Tubular Dysgenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 76)
idRelated DiseaseScoreTop Affiliating Genes
1renal tubular dysgenesis, ace-related12.0
2renal tubular dysgenesis, agt-related12.0
3renal tubular dysgenesis, agtr1-related12.0
4renal tubular dysgenesis, ren-related12.0
5renal tubular dysgenesis due to twin-twin transfusion12.0
6drug-related renal tubular dysgenesis12.0
7pediatric ulcerative colitis10.2ACE, AGT
8perineocele10.1ACE, AGT
9hypotelorism cleft palate hypospadias10.1ACE, REN
10vertebrobasilar insufficiency10.1ACE, AGT
11cystic kidney disease10.1ACE, REN
12hypodermyasis10.1ACE, REN
13atrial septal defect 7, with or without av conduction defects10.1ACE, REN
14degenerative myopia10.1ACE, REN
15hemochromatosis10.1
16oligohydramnios10.1
17voyeurism10.1ACE, REN
18hypoaldosteronism, congenital, due to cmo ii deficiency10.1AGT, REN
19mental depression10.1ACE, REN
20benign neonatal seizures10.0ACE, REN
21central nervous system angiosarcoma10.0ACE, REN
22frontal sinus cancer10.0ACE, AGT
23episodic kinesigenic dyskinesia 210.0AGT, REN
24spinal canal and spinal cord meningioma10.0ACE, REN
25diabetic encephalopathy10.0ACE, REN
26chronic myelomonocytic leukemia9.9ACE, REN
27periampullary adenoma9.9ACE, REN
28familial hypopituitarism9.9AGT, AGTR1
29common wart9.9ACE, REN
30podder-tolmie syndrome9.9AGT, AGTR1
31survival motor neuron spinal muscular atrophy9.9ACE, REN
32hypopigmentation of eyelid9.9ACE, AGTR1
33adams-oliver syndrome9.9ACE, AGT
34acute myeloblastic leukemia without maturation9.9ACE, AGTR1
35alpha-2-plasmin inhibitor deficiency9.9ACE, AGTR1
36discitis9.8ACE, AGTR1
37kidney hypertrophy9.8ACE, AGTR1
38preeclampsia/eclampsia 19.8AGT, AGTR1
39meconium ileus9.8
40microcephaly9.8
41nephrocalcinosis9.8
42nephronophthisis9.8
43intestinal perforation9.8
44ischemia9.8
45pyelonephritis9.7ACE, AGT
46adrenal rest tumor9.7ACE, REN
47perrault syndrome9.7AGTR1, REN
48pleural tuberculosis9.7AGT, AGTR1
49plica syndrome9.7ACE, AGT, REN
50cystinosis9.7ACE, AGT, REN

Graphical network of the top 20 diseases related to Renal Tubular Dysgenesis:



Diseases related to renal tubular dysgenesis

Symptoms & Phenotypes for Renal Tubular Dysgenesis

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Symptoms by clinical synopsis from OMIM:

267430

Clinical features from OMIM:

267430

Human phenotypes related to Renal Tubular Dysgenesis:

 64 54 (show all 23)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormality of the renal tubule64 hallmark (90%) HP:0000091
2 polycystic kidney dysplasia64 hallmark (90%) HP:0000113
3 hypertelorism64 54 hallmark (90%) Very frequent (99-80%) HP:0000316
4 joint hypermobility64 hallmark (90%) HP:0001382
5 polyhydramnios64 54 hallmark (90%) Very frequent (99-80%) HP:0001561
6 premature birth64 54 hallmark (90%) Very frequent (99-80%) HP:0001622
7 aplasia/hypoplasia of the lungs64 hallmark (90%) HP:0006703
8 nephropathy64 54 occasional (7.5%) Occasional (29-5%) HP:0000112
9 microcephaly64 54 occasional (7.5%) Occasional (29-5%) HP:0000252
10 single transverse palmar crease64 occasional (7.5%) HP:0000954
11 oligohydramnios64 54 occasional (7.5%) Occasional (29-5%) HP:0001562
12 tetralogy of fallot64 54 occasional (7.5%) Occasional (29-5%) HP:0001636
13 potter facies64 HP:0002009
14 pulmonary hypoplasia64 54 Very frequent (99-80%) HP:0002089
15 respiratory insufficiency64 HP:0002093
16 hypotension64 HP:0002615
17 widely patent fontanelles and sutures64 HP:0004492
18 renotubular dysgenesis64 54 Very frequent (99-80%) HP:0008660
19 anuria64 HP:0100519
20 proximal tubulopathy54 Very frequent (99-80%)
21 multiple renal cysts54 Very frequent (99-80%)
22 joint hyperflexibility54 Very frequent (99-80%)
23 bilateral single transverse palmar creases54 Occasional (29-5%)

MGI Mouse Phenotypes related to Renal Tubular Dysgenesis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.6ACE, AGT, AGTR1
2MP:00053868.8ACE, AGT, AGTR1, REN
3MP:00053858.8ACE, AGT, AGTR1, REN
4MP:00053878.7ACE, AGT, AGTR1, REN
5MP:00053678.0ACE, AGT, AGTR1, REN

Drugs & Therapeutics for Renal Tubular Dysgenesis

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Drugs for Renal Tubular Dysgenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 106)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Emtricitabineapproved, investigationalPhase 4439143491-57-060877
Synonyms:
(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-.beta.-L-FTC
(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-2'-Deoxy-5-fluoro-3'-thiacytidine
(-)-FTC
(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine
(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine
(-)-cis-4-amino-5-Fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
(2R-cis)-4-amino-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine
143491-54-7
143491-57-0
145213-48-5
2',3',5-FTC
2',3'-Dideoxy-5-fluoro-3'-thiacytidine
2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine
2'-Deoxy-5-fluoro-3'-thiacytidine
2-FTC
3'-Thia-2'.3'-dideoxy-5-fluorocytidine
4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one
4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
4-amino-5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine
524W91
AC1L1U3I
AC1Q4KUB
BW 1592
 
BW 524W91
BW-524W91
BW524W91
C122114
C12599
C8H10FN3O3S
CHEBI:31536
CHEMBL885
CID60877
Coviracil
Coviracil(TM)
D01199
DB00879
DRG-0208
Emtricitabin
Emtricitabina
Emtricitabine
Emtricitabine (JAN/USAN/INN)
Emtricitabinum
Emtriva
Emtriva (TN)
Emtriva(TM)
FT-0080009
HMS2089I05
HSDB 7337
LS-135838
LS-173184
NCGC00164564-01
RCV
Racivir
SBB066061
TL8000958
UNII-G70B4ETF4S
ZINC03629271
beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine
dOTFC
emtricitabine
2
CobicistatapprovedPhase 4831004316-88-4
Synonyms:
 
1,3-thiazol-5-ylmethyl [(2R,5R)-5-{[(2S)-2-({[(2-isopropyl-1,3-thiazol-4-yl)methyl](methyl)carbamoyl}amino)-4-(morpholin-4-yl)butanoyl]amino}-1,6-diphenylhexan-2-yl]carbamate
3
Ritonavirapproved, investigationalPhase 4870155213-67-5392622
Synonyms:
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate
155213-67-5
1hxw
1sh9
5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate
5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate
538, ABT
A-84538
ABBOTT-84538
ABT 538
ABT 84538
ABT-538
ABT538
AC-733
AC1L94GB
AKOS000280930
Abbott 84538
BIDD:GT0387
BIDD:PXR0023
Bio-0093
C07240
C37H48N6O5S2
CHEBI:45409
CHEMBL163
CID392622
CPD000466395
D00427
D019438
 
DB00503
DRG-0244
FT-0082824
HMS2051B08
HSDB 7160
LS-148860
MLS000759541
MLS001424063
MolPort-000-883-877
N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide
NCGC00159462-02
NSC693184
Norvir
Norvir (TM)
Norvir (TN)
Norvir Sec
RIT
RTV
Ritonavir
Ritonavir (JAN/USAN/INN)
Ritonavir [USAN]
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.
Ritonavirum
S1185_Selleck
SAM001246783
SMR000466395
STK634209
ZINC03944422
ritonavir
4
Efavirenzapproved, investigationalPhase 4405154598-52-464139
Synonyms:
(-)-6-CHLORO-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one
(-)-Efavirenz
(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
(S)-6-Chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-ben
(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
(S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one
154598-52-4
1ikv
1ikw
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (9
6-chloro-4-(2-Cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[D][1,3]oxazin-2-one
6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
AC-19049
AC1L20IX
BIDD:GT0383
C08088
C14H9ClF3NO2
CHEBI:119486
CHEMBL223228
CID64139
CPD000466351
D00896
DB00625
DB07709
DMP 266
DMP-266
EFV
 
EFZ
Efavirenz
Efavirenz (JAN/INN)
Efavirenzum
Eravirenz
HMS2051J08
HMS2090N16
HSDB 7163
L 743726
L-741211
L-743,726
L-743725
L-743726
LS-173464
MLS000759465
MLS001424087
Met-SDF-1.beta. & Efavirenz
Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz
MolPort-003-983-924
NSC742403
SAM001246667
SBB066062
SMR000466351
Stocrin
Strocin (TM)
Sustiva
Sustiva (TM)
Sustiva (TN)
UNII-JE6H2O27P8
ZINC02020233
efavirenz
efavirenz, (S)-isomer
zoxazin-2-one
Éfavirenz
5
Abacavirapproved, investigationalPhase 4211136470-78-565140, 441300
Synonyms:
(+/-)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
(+/-)-Abacavir
(1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol
136470-78-5
1592U89
168146-84-7
ABC
AC1L9AXG
Abacavir (INN)
Abacavir [INN]
Bio-0001
C07624
CHEBI:421707
 
CHEMBL1380
CID441300
D07057
DB01048
Epzicom
NCGC00164560-01
NCGC00164560-02
NSC742406
Trizivir
ZINC02015928
Ziagen
Ziagen (TM)(*Succinate salt*)
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol
abacavir
{(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol
6
Lamivudineapproved, investigationalPhase 4613134678-17-460825
Synonyms:
(+/-) (Cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(+/-)-3TC
(+/-)-BCH-189
(+/-)-SddC
(-)-(2'R,5'S)-1-[2'-Hydroxymethyl-5'-(1,3-oxathiolanyl)]cytosine
(-)-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine
(-)-1-[(2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
(-)-2'-Deoxy-3'-thiacytidine
(-)-BCH 189
(-)-BCH-189
(-)-SddC
(-)-beta-L-2',3'-Dideoxy-3'-thiacytidine
(-)NGPB-21
(2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one
.beta.-L-(-)-2',3'-dideoxy-3'-thiacytidine & Sho-Saiko-To
134678-17-4
2',3' Dideoxy 3' thiacytidine
2',3'-Dideoxy-3'-thiacytidine
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (+/-) (Cis)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Galanthus Nivalis Agglutinin (GNA)
2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl], (-)(2R,5S) & Hippeastrum hybrid agglutinin( HHA)
3'-Thia-2',3'-dideoxycytidine
3TC
3TC & GNA
3TC & SST
3TC (AIDS INITIATIVE) (AIDS INITIATIVE)
3TC and NV-01
3TC, Zeffix, Heptovir, Epivir, Epivir-HBV, Lamivudine
4-Amino-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one
4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one
480434-79-5
AC-1416
AC1L1TZZ
AC1Q6C34
BCH 189
BCH-189
BCH-790
BCH189
BIDD:GT0033
Bio-0652
C07065
C8H11N3O3S
CCRIS 9274
CHEBI:133986
CHEMBL141
CID60825
CPD000466319
D00353
D019259
 
DB00709
DRG-0126
DTHC
Epivir
Epivir (TN)
Epivir(TM)
Epivir-HBV
Epzicom
FT-0082667
GG-714
GR 109714X
GR-109714X
GR109714X
HHA & 3TC
HHA & Lamivudine
HMS2051D21
HSDB 7155
Hepitec
Heptivir
Heptodin
Heptovir
L0217
LMV
LS-2107
Lamivir
Lamivudin
Lamivudina
Lamivudine
Lamivudine & GNA
Lamivudine (JAN/USP/INN)
Lamivudine [USAN:BAN:INN]
Lamivudine [USAN:INN:BAN]
Lamivudine [Usan:Ban:Inn]
Lamivudine, (2S-cis)-Isomer
Lamivudinum
MLS000759424
MLS001424097
MolPort-002-507-347
NCGC00159341-03
NCGC00159341-04
NSC620753
S1706_Selleck
SAM001246582
SAM002589994
SMR000466319
STK801940
UNII-2T8Q726O95
ZINC00012346
Zeffix
Zefix
beta-L-2',3'-Dideoxy-3'-thiacytidine
beta-L-3'-Thia-2',3'-dideoxycytidine
lamivudine
7
Tenofovirapproved, investigationalPhase 4733147127-20-6464205
Synonyms:
(R)-9-(2-Phosphonomethoxypropyl)adenine
(R)-9-(2-Phosphonylmethoxypropyl)adenine
(R)-9-(2-phosphonomethoxypropyl)adenine
(R)-PMPA
147127-20-6
206184-49-8
AC-760
AC1LA9BO
Anh. tenofovir
Anhydrous tenofovir
Apropovir
CHEBI:45809
CHEMBL483
CID464205
D,L-Tenofovir
DB00300
GNA & Tenofovir
GS 1275
GS 1278
GS1278
 
HHA & Tenofovir
KS-5021
MolPort-003-850-411
NCGC00167535-01
PMPA
PMPA-(R)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)
Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)
Phosphonic acid, [[2-(6-amino-9H-purin-9
S1401_Selleck
TDF
TFV
Tenefovir
Tenofovir
Tenofovir (anh.)
Tenofovir disoproxil
Tenofovir disoproxil fumarate
UNII-99YXE507IL
Viread
Viread, Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
8
GliclazideapprovedPhase 45721187-98-43475
Synonyms:
1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea
1-(3-Azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea
1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea
1-(Hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)urea
21187-98-4
AB00053165
AB1004595
AC-12045
AC1L1G0Q
AKOS003237903
BPBio1_000699
BRD-A61154809-001-04-3
BRN 1657836
BSPBio_000635
BSPBio_003304
Bio-0502
C15H21N3O3S
CHEBI:31654
CHEMBL427216
CID3475
D01599
DB01120
Diaikron
Diamicron
Diamicron MR
DivK1c_006966
EINECS 244-260-5
G2167_SIGMA
Gliclazida
Gliclazida [INN-Spanish]
Gliclazide (JAN/INN)
Gliclazide [BAN:INN:DCF:JAN]
Gliclazidum
Gliclazidum [INN-Latin]
Gliklazid
Glimicron
Glimicron (TN)
Glyclazide
HMS1569P17
HMS1922D15
HMS2090K16
I06-0117
KBio1_001910
 
KBio2_001958
KBio2_004526
KBio2_007094
KBio3_002806
KBioGR_001096
KBioSS_001958
LS-160299
MLS001215197
MLS001304077
MLS001304118
MolPort-002-507-779
Mylan-Gliclazide
N-(4-Methylbenzenesulfonyl)-N'-(3-azabicyclo(3.3.0)oct-3-yl)urea
N-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbamoyl)-4-methylbenzenesulfonamide
N-[(hexahydrocyclopenta[c]pyrrol-2(1H)-ylamino)carbonyl]-4-methylbenzenesulfonamide
NCGC00095107-01
NCGC00095107-02
NCGC00095107-03
NCGC00095107-04
NCGC00095107-05
NCGC00095107-06
Nordialex
PMS-Gliclazide
Prestwick0_000558
Prestwick1_000558
Prestwick2_000558
Prestwick3_000558
Prestwick_869
S 1702
S 852
S-1702
S-852
SE 1702
SMR000542971
SPBio_002556
SPECTRUM1504145
SPECTRUM1505013
STK803142
SpecPlus_000870
Spectrum3_001862
Spectrum4_000598
Spectrum5_000753
Spectrum_001478
gliclazide
9
MetforminapprovedPhase 41746657-24-914219, 4091
Synonyms:
1,1-Dimethyl biguanide
1,1-Dimethylbiguanide
3-(diaminomethylidene)-1,1-dimethylguanidine
657-24-9
AC1L1HE4
AKOS000121065
Apo-Metformin
BIDD:GT0697
BPBio1_000009
BRD-K79602928-003-04-1
BSPBio_000007
BSPBio_002314
C07151
C4H11N5
CAS-1115-70-4
CCRIS 9321
CHEBI:6801
CHEMBL1431
CID4091
D04966
DB00331
DMGG
Diabetosan
Diabex
Dimethylbiguanid
Dimethylbiguanide
Dimethylbiguanidine
Dimethyldiguanide
Dimethylguanylguanidine
EINECS 211-517-8
Fluamine
Flumamine
Fortamet
Gen-Metformin
Glifage
Gliguanid
Glucophage
Glucophage XR
Glumetza
Glycon
HMS2089D19
HSCI1_000295
Haurymelin
Haurymellin
Islotin
KBio2_002310
KBio2_004878
KBio2_007446
KBio3_002790
KBioGR_002310
 
KBioSS_002312
LA-6023
LS-43899
Melbin
Metformin
Metformin (USAN/INN)
Metformin HCL
Metformin [USAN:INN:BAN]
Metformina
Metformina [DCIT]
Metformina [Spanish]
Metformine
Metformine [INN-French]
Metformine pamoate
Metforminum
Metforminum [INN-Latin]
Metiguanide
MolPort-002-929-560
MolPort-004-288-389
MolPort-005-767-418
Mylan-Metformin
N,N-Dimethylbiguanide
N,N-Dimethyldiguanide
N,N-Dimethylimidodicarbonimidic diamide
N,N-dimethylimidodicarbonimidic diamide
N1,N1-Dimethylbiguanide
NCGC00016564-01
NCGC00016564-02
NCGC00016564-03
NNDG
Novo-Metformin
Nu-Metformin
PMS-Metformin
Prestwick0_000004
Prestwick1_000004
Prestwick2_000004
Prestwick3_000004
Ran-Metformin
Ratio-Metformin
Riomet
S2483_Selleck
SPBio_001928
STK011633
Sandoz Metformin
Siofor
T5895664
Teva-Metformin
UNII-9100L32L2N
ZINC12859773
cMAP_000016
metformin
metformin hydrochloride
10
Miconazoleapproved, investigational, vet_approvedPhase 4, Phase 1362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
11
SpironolactoneapprovedPhase 42221952-01-7, 52-01-75833
Synonyms:
4-18-00-01601 (Beilstein Handbook Reference)
4-Pregnen-21-oic acid-17alpha-ol-3-one-7alpha-thiol gamma-lactone 7-acetate
496916-40-6
52-01-7
7-alpha-Acetylthio-3-oxo-17-alpha-pregn-4-ene-21,17-beta-carbolactone
7alpha-(acetylsulfanyl)-3-oxo-17alpha-pregn-4-ene-21,17-carbolactone
AB00513806
AC-4214
AC1L1L8Q
Abbolactone
Acelat
Aldace
Aldactazide
Aldactide
Aldactone
Aldactone (TN)
Aldactone A
Alderon
Aldopur
Almatol
Alphapharm Brand of Spironolactone
Alpharma Brand of Spironolactone
Alter Brand of Spironolactone
Altex
Aquareduct
Ashbourne Brand of Spironolactone
Azupharma Brand of Spironolactone
BIDD:PXR0071
BPBio1_000194
BRD-K90027355-001-03-4
BRN 0057767
BSPBio_000176
C07310
C24H32O4S
CHEBI:428201
CHEBI:45692
CHEBI:9241
CHEMBL1393
CID5833
CPD000471892
Cardel Brand of Spironolactone
D00443
D013148
DB00421
Deverol
Dexo Brand of Spironolactone
Diatensec
Dira
Duraspiron
EINECS 200-133-6
Espironolactona
Espironolactona Alter
Espironolactona Mundogen
Espironolactona [INN-Spanish]
Euteberol
Flumach
Frumikal
Generosan Brand of Spironolactone
HMS1568I18
HMS2090N21
HSDB 3184
Hormosan Brand of Spironolactone
I06-1970
Jenapharm Brand of Spironolactone
Jenaspiron
LS-118614
LT00772287
Lacalmin
Lacdene
Laractone
MLS001074672
MLS001333253
MLS001333254
MLS002153245
MLS002207058
Mayoly-Spindler Brand of Spironolactone
Melarcon
Merck dura Brand of Spironolactone
Mundogen Brand of Spironolactone
NCGC00164397-01
 
NCGC00164397-02
NSC 150399
NSC150399
Nefurofan
Novo Spiroton
Novo-Spiroton
NovoSpiroton
Novopharm Brand of Spironolactone
Osyrol
Pfizer Brand of Spironolactone
Pharmafrid Brand of Spironolactone
Practon
Prestwick0_000128
Prestwick1_000128
Prestwick2_000128
Prestwick3_000128
Roche Brand of Spironolactone
S0260
S3378_SIGMA
SAM002264648
SC 9420
SC-9420
SC9420
SMR000471892
SNL
SPBio_002115
Sagisal
Searle Brand of Spironolactone
Sincomen
Spiractin
Spiresis
Spiretic
Spiridon
Spiro L.U.T.
Spiro(17H-cyclopenta(a)phenauthrene-17,2'-(3'H)-furan)
Spiro-Tablinen
Spiro[17H-cyclopenta[a]phenauthrene-17,2'-(3'H)-furan]
Spirobeta
Spiroctan
Spiroctanie
Spiroderm
Spirogamma
Spirolactone
Spirolakton
Spirolang
Spirolone
Spirone
Spirono Isis
Spirono-Isis
Spironocompren
Spironolactone
Spironolactone (JP15/USP/INN)
Spironolactone A
Spironolactone [BAN:INN:JAN]
Spironolactone [INN:BAN:JAN]
Spironolactonum
Spironolactonum [INN-Latin]
Spironolattone
Spironolattone [DCIT]
Spironone
Spirospare
Sprioderm
Supra-puren
Suracton
UNII-27O7W4T232
Uractone
Urusonin
Veroshpiron
Verospiron
Verospirone
Verospirone Opianin
WLN: L E5 B666 FX OV MUTJ A1 E1 KSV1 F-& CT5VOXTJ
Worwag Brand of Spironolactone
Xenalon
ZINC03861599
betapharm Brand of Spironolactone
ct Arzneimittel Brand of Spironolactone
ct-Arzneimittel Brand of Spironolactone
spiro von ct
spironolactone
spironolattone
von ct, spiro
12
Amphotericin Bapproved, investigationalPhase 41181397-89-314956, 5280965
Synonyms:
12633-72-6
1397-89-3
30782-62-8
5-18-10-00525 (Beilstein Handbook Reference)
54482-28-9
8055-20-7
AB00513832
ABLC
AC1L1CN2
AC1L24V6
AC1L70KF
AC1L73U6
AC1NQXTD
AC1NTQ32
AC1NUQG4
AC1NY9JC
AC1O7GCZ
AC1O8FQV
AC1O8PFK
AI3-26528
AMPH-B
AMPH-b
Abelcet
Abelecet
AmBisome (TN)
Ambap1397-89-3
Ambisome
Amfotericina B
Amfotericina B [INN-Spanish]
Ampho-Moronal
Amphocin
Amphomoronal
Amphortericin B
Amphotec
Amphotec (TN)
Amphotericin
Amphotericin .BETA.
Amphotericin B
Amphotericin B (JP15/USP/INN)
Amphotericin B Cholesterol Dispersion
Amphotericin B Colloidal Dispersion
Amphotericin B [USAN:INN:JAN]
Amphotericin B, Lipid-based
Amphotericin B, Streptomyces sp.
Amphotericin-B
Amphotericine B
Amphotericine B [INN-French]
Amphotericinum
Amphotericinum B
Amphotericinum B [INN-Latin]
Amphotherizin
Amphotherizin [German]
Amphotéricine B
Amphozone
BIDD:GT0351
BPBio1_000374
BRN 0078342
BSPBio_000340
C-AmB
C06573
C47H73NO17
CCRIS 5963
CHEBI:2682
CHEMBL1200646
CHEMBL267345
CID10533925
CID10629638
CID10677275
CID14956
CID1972
 
CID352546
CID354192
CID5280965
CID5386092
CID5458486
CID5771695
CID6604295
CID6708817
CID6713692
CID9919339
D00203
DB00681
DivK1c_007045
EINECS 215-742-2
Fungilin
Fungisome
Fungisone
Fungizone
Fungizone (TN)
HMS1569A22
HSDB 3008
HSDB 3008 IAB
Halizon
I06-0257
KBio1_001989
KBio2_000551
KBio2_003119
KBio2_005687
KBioGR_002298
KBioSS_000551
LMPK06000002
LNS-AmB
LS-187721
LS-93
Liposomal Amphotericin B
Liposomal amphotericin b
MLS002702966
MolPort-006-392-260
Mysteclin-F
NCGC00014913
NCGC00090808-01
NCGC00098014-01
NCGC00179595-01
NCI527017
NCI60_004288
NCIStruc1_001042
NCIStruc2_000920
NKTR-024
NS 718
NSC 527017
NSC-527017
NSC527017
Prestwick0_000410
Prestwick1_000410
Prestwick2_000410
Prestwick3_000410
Prestwick_721
SMP1_000302
SMR001566780
SPBio_000715
SPBio_002279
ST50999656
SinuNase
SpecPlus_000949
Spectrum2_000818
Spectrum4_001779
Spectrum_000111
UNII-7XU7A7DROE
amophotericin B
amphotericin B liposomal
amphotericin b
13HormonesPhase 4, Phase 1, Phase 213979
14Anti-Infective AgentsPhase 4, Phase 2, Phase 121402
15Anti-Bacterial AgentsPhase 4, Phase 110884
16MineralocorticoidsPhase 4352
17Anti-HIV AgentsPhase 43100
18Emtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationPhase 4237
19Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 4, Phase 1, Phase 212767
20Hormone AntagonistsPhase 4, Phase 1, Phase 212778
21Anti-Retroviral AgentsPhase 43232
22Antiviral AgentsPhase 4, Phase 19732
23Pharmaceutical SolutionsPhase 47793
24Nucleic Acid Synthesis InhibitorsPhase 44855
25Efavirenz, Emtricitabine, Tenofovir Disoproxil Fumarate Drug CombinationPhase 466
26HIV Protease InhibitorsPhase 45319
27
protease inhibitorsPhase 45320
Synonyms:
 
protease inhibitors
28Reverse Transcriptase InhibitorsPhase 41880
29Cytochrome P-450 Enzyme InhibitorsPhase 43822
30Atazanavir SulfatePhase 4223
31Cytochrome P-450 CYP3A InhibitorsPhase 41666
32Hypoglycemic AgentsPhase 45733
33Antifungal AgentsPhase 4, Phase 13615
34Mineralocorticoid Receptor AntagonistsPhase 4333
35Natriuretic AgentsPhase 41645
36Diuretics, Potassium SparingPhase 41827
37Liposomal amphotericin BPhase 4118
38Antiparasitic AgentsPhase 42127
39Antiprotozoal AgentsPhase 41986
40diureticsPhase 41372
41
LenograstimapprovedPhase 21202135968-09-1
Synonyms:
G-CSF (CHO cell derived)
Glycosylated recombinant G-CSF
Glycosylated recombinant granulocyte colony stimulating factor
 
Granulocyte colony stimulating factor 3 (CHO cell derived)
Granulocyte colony-stimulating factor lenograstim
Lenograstim (genetical recombination)
Lenograstim rDNA
42
SulfamethoxazoleapprovedPhase 2158723-46-65329
Synonyms:
129378-89-8
3-(Para-Aminophenylsulphonamido)-5-methylisoxazole
3-(p-Aminobenzenesulfonamido)-5-methylisoxazole
3-(p-Aminophenylsulfonamido)-5-methylisoxazole
3-(para-Aminophenylsulphonamido)-5-methylisoxazole
3-Sulfanilamido-5-methylisoxazole
3-Sulphanilamido-5-methylisoxazole
4-Amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4-Amino-N-(5-methyl-3-isoxazolyl)-Benzenesulfonamide
4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
4-Amino-N-(5-methyl-isoxazol-3-yl)-benzenesulfonamide
4-Amino-N-[5-methyl-3- isoxazolyl]benzenesulfonamide
4-amino-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide
4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide
46850_RIEDEL
5-Methyl-3-sulfanilamidoisoxazole
5-Methyl-3-sulfanylamidoisoxazole
5-Methyl-3-sulfonylamidoisoxazole
5-Methyl-3-sulphanil-amidoisoxazole
723-46-6
A047
AB00052099
AC-11118
AC1L1K42
AC1Q2J5R
AKOS000200952
ALBB-002089
ARONIS018156
Apo-Sulfamethoxazole
Azo Gantanol
Azo-Gantanol
Azo-gantanol
BAS 00836086
BB_SC-1251
BIDD:GT0731
BPBio1_000081
BRD-K28494619-001-05-0
BRN 0226453
BSPBio_000073
BSPBio_002028
Bactrim
Bactrimel
C07315
C10H11N3O3S
CAS-723-46-6
CCRIS 567
CHEBI:9332
CHEMBL443
CID5329
CPD000058223
D00447
D013420
DB01015
DivK1c_000649
EINECS 211-963-3
Gamazole
Gantanol
Gantanol (TN)
Gantanol (tn)
Gantanol-DS
HMS1568D15
HMS1921A21
HMS2092K03
HMS502A11
HMS561O18
HSDB 3186
I01-0154
IDI1_000649
InChI=1/C10H11N3O3S/c1-7-6-10(12-16-7)13-17(14,15)9-4-2-8(11)3-5-9/h2-6H,11H2,1H3,(H,12,13)
KBio1_000649
KBio2_001474
KBio2_004042
KBio2_006610
KBio3_001528
KBioGR_000749
KBioSS_001474
LS-1620
MLS000069732
MLS001055354
MLS001074165
MS 53
Maybridge1_007190
Metoxal
MolPort-000-145-787
N'-(5-Methyl-3-isoxazole)sulfanilamide
 
N'-(5-Methyl-3-isoxazolyl)-Sulfanilamide
N'-(5-Methyl-3-isoxazolyl)sulfanilamide
N'-(5-Methylisoxazol-3-yl)sulphanilamide
N(Sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N(sup 1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N(sup 1)-(5-Methyl-3-isoxazolyl)sulphanilamide
N(sup1)-(5-Methyl-3-isoxazolyl)sulfanilamide
N1-(5-Methyl-3-isoxazolyl)sulfanilamide
N1-(5-Methyl-3-isoxazolyl)sulphanilamide
N1-(5-Methylisoxazol-3-yl)sulfanilamide
N1-(5-methyl-3-isoxazolyl)-Sulfanilamide
NCGC00016533-01
NCGC00016533-02
NCGC00021995-03
NCGC00021995-04
NCGC00021995-05
NINDS_000649
NSC 147832
NSC147832
N^1-(5-Methyl-3-isoxazolyl)-Sulfanilamide
Ndimethyl1-(5-methyl-3-isoxazolyl)-Sulfanilamide
Oprea1_114486
Oprea1_285680
Prestwick0_000177
Prestwick1_000177
Prestwick2_000177
Prestwick3_000177
Prestwick_453
Radonil
Ro 4-2130
Ro 6-2580/11
Ro-4-2130
S0361
S1915_Selleck
S7507_FLUKA
S7507_SIGMA
SAM002554930
SIM
SMR000058223
SMX
SPBio_000896
SPBio_001994
SPECTRUM1500550
STK007988
SULFAMETHOXAZOLE (8064-90-2 (TRIMETHOPRIM/SULFAMETHOXAZOLE)
Septran
Simsinomin
Sinomin
Solfametossazolo
Solfametossazolo [DCIT]
Spectrum2_000788
Spectrum3_000584
Spectrum4_000345
Spectrum5_000982
Spectrum_000994
Sulfamethalazole
Sulfamethoxazol
Sulfamethoxazole
Sulfamethoxazole (JP15/USP/INN)
Sulfamethoxazole [USAN:INN:JAN]
Sulfamethoxazole sodium
Sulfamethoxazole(USAN)
Sulfamethoxazolum
Sulfamethoxazolum [INN-Latin]
Sulfamethoxizole
Sulfamethylisoxazole
Sulfametoxazol
Sulfametoxazol [INN-Spanish]
Sulfanilamide, N1-(5-methyl-3-isoxazolyl)- (8CI)
Sulfisomezole
Sulpha-Methoxizole
Sulpha-methoxizole
Sulphamethalazole
Sulphamethoxazol
Sulphamethoxazole
Sulphamethoxazole BP 98
Sulphamethylisoxazole
Sulphisomezole
TL8005058
TMP/SMX (MIXTURE))
Trib
UNII-JE42381TNV
Urobak
WLN: T5NOJ C1 EMSWR DZ
ZINC00089763
nchembio.221-comp24
sulfamethoxazole
43
DanazolapprovedPhase 1, Phase 21617230-88-528417
Synonyms:
(17a)-Pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol
(1R,3aS,3bR,10aR,10bS,12aS)-1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol
(1S,2R,13R,14S,17R,18S)-17-ethynyl-2,18-dimethyl-7-oxa-6-azapentacyclo[11.7.0.0^{2,10}.0^{4,8}.0^{14,18}]icosa-4(8),5,9-trien-17-ol
1-Ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-1H-cyclopenta[7,8]phenanthro[3,2-d]isoxazol-1-ol
1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-Cyclopenta[7,8]phenanthro[3,2-D]isoxazol-1-ol
17 alpha-Pregna-2,4-dien-20-yno[2,3-D] isoxazol-17 beta-ol
17-alpha-2,4-Pregnadien-20-yno(2,3-d)isoxazol-17-ol
17-alpha-Pregn-4-en-20-yno(2,3-d)isoxazol-17-ol
17-alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
17.Alpha.-Pregna-2, {4-dien-20-yno[2,3-d]isoxazol-17-ol}
17230-88-5
17a-Pregna-2,4-dien-20-yne-[2,3-D]isoxazole-17b-ol
17a-Pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol
17alpha-Pregna-2,4-dien-20-yno(2,3-d)isoxazol-17-ol
1H-Cyclopenta[7,8]phenanthro[3,2-D]isoxazole- pregna-2,4-dien-20-yno[2,3-D]isoxazol-17-ol deriv.
AC-6836
AC1L1FAD
AC1Q282K
AC1Q29FD
Alphapharm Brand of Danazol
Antigen Brand of Danazol
BPBio1_000100
BRD-K48970916-001-03-0
BSPBio_000090
Bonzol
CCRIS 6747
CHEBI:4315
CHEMBL1479
CID28417
CPD000058321
Chronogyn
Cyclomen
D00289
D003613
DB01406
Danatrol
Danazant
Danazol (JAN/USP/INN)
Danazol [USAN:BAN:INN:JAN]
Danazol-ratiopharm
Danazole
Danazolum
Danazolum [INN-Latin]
Danocrine
 
Danocrine (TN)
Danogen
Danokrin
Danol
Danoval
Danovaol
Danzol
EINECS 241-270-1
HMS1568E12
HMS2090A22
Kendrick Brand of Danazol
LS-118524
Ladogal
MLS001066617
MLS001306473
MolPort-002-513-504
NCGC00164400-01
NCGC00179665-01
NSC 270916
NSC270916
Norciden
Panacrine
Prestwick0_000105
Prestwick1_000105
Prestwick2_000105
Prestwick3_000105
Prestwick_150
SAM002564203
SMR000058321
SPBio_002029
STOCK1N-23495
Sanofi Brand of Danazol
Sanofi Synthelabo Brand of Danazol
Sanofi Winthrop Brand of Danazol
UNII-N29QWW3BUO
WIN 17,757
WIN 17757
WIN-17757
Win 17, 757
Winobanin
ZINC03881958
[1,2]oxazolo[4',5':2,3]-17alpha-pregn-4-en-20-yn-17-ol
anatrol
danazol
ratiopharm Brand of Danazol
44Antirheumatic AgentsPhase 2, Phase 110627
45Peripheral Nervous System AgentsPhase 222776
46Anti-Inflammatory Agents, Non-SteroidalPhase 24295
47Anti-Inflammatory AgentsPhase 210355
48AnalgesicsPhase 211287
49Analgesics, Non-NarcoticPhase 26260
50Adjuvants, ImmunologicPhase 22484

Interventional clinical trials:

(show all 35)
idNameStatusNCT IDPhase
1Renal Effect of Stribild or Other Tenofovir DF-containing Regimens Compared to Ritonavir-boosted Atazanavir Plus Abacavir/Lamivudine in Antiretroviral Treatment-naive HIV-1 Infected AdultsCompletedNCT02246998Phase 4
2Renoprotective Effects of Dapagliflozin in Type 2 DiabetesRecruitingNCT02682563Phase 4
3Use of Spironolactone for the Prevention of Electrolyte Abnormalities in Patients Treated With Amphotericin BTerminatedNCT01843309Phase 4
4Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure SyndromesCompletedNCT00004787Phase 2
5A Study of KRN23 in Subjects With Tumor-Induced Osteomalacia or Epidermal Nevus SyndromeActive, not recruitingNCT02722798Phase 2
6Sulfamethoxazole for the Treatment of Primary PREPL DeficiencyEnrolling by invitationNCT02640443Phase 2
7Trial in Patients With CystinuriaNot yet recruitingNCT02942420Phase 2
8Safety and Efficacy Trial of Danazol in Patients With Fanconi Anemia or Dyskeratosis CongenitaTerminatedNCT01001598Phase 1, Phase 2
9Pilot Study of Mycophenolate Mofetil in Congenital UropathiesCompletedNCT00193635Phase 1
10Quercetin in Children With Fanconi Anemia; a Pilot StudyRecruitingNCT01720147Phase 1
11BMT Abatacept for Non-Malignant DiseasesRecruitingNCT01917708Phase 1
12Low-Dose Total-Body Irradiation and Fludarabine Phosphate Followed by Unrelated Donor Stem Cell Transplant in Treating Patients With Fanconi AnemiaActive, not recruitingNCT00093743Phase 1
13Use of Rft5-Dga to Deplete Alloreactive Cells for Pts With Fanconi Anemia After Haploidentical SCTTerminatedNCT00586274Phase 1
14Long Term Outcome of Congenital Solitary KidneyUnknown statusNCT01831141
15PREPL in Health and DiseaseUnknown statusNCT02263781
16Metabolic Screening in Patients With Donnai-Barrow SyndromeUnknown statusNCT01509287
17Research Network for Neonatal Diseases Induced by Tissular Fetomaternal AlloimmunizationUnknown statusNCT00199628
18Assessment and Monitoring of Renal Proximal Tubular Tolerance of Nucleoside and Nucleotide Analogues Using Early Screening Tools in Patients Chronically Mono-infected With Hepatitis B VirusCompletedNCT01500265
19Severe Impairment of Solute-Free Water Clearance in Patients With HIV InfectionCompletedNCT01869010
20Cardiovascular Evaluation of Adult PHA 1 PatientsCompletedNCT00646828
21Study of the Pathophysiological Mechanisms Involved in Bleeding EventsCompletedNCT01314560
22Genetic Analysis of Oculocerebrorenal Syndrome of LoweCompletedNCT00359515
23Pilot Study of Etanercept (Enbrel) in Children With Fanconi AnemiaCompletedNCT00965666
24Assessing Immune Function in Young Patients With Cytopenia That Did Not Respond to TreatmentCompletedNCT00499070
25Interest to Perform a Renal Biopsy Early in the Course of the Henoch-Schoenlein NephritisRecruitingNCT02811770
26Clinical Observation on Bone Metabolism Induced by Chronic Renal InsufficiencyRecruitingNCT02147782
27Prospective Research Rare Kidney Stones (ProRKS)RecruitingNCT02780297
28Investigation of the Genetics of Hematologic DiseasesRecruitingNCT02720679
29Clinical and Molecular Investigations Into CiliopathiesActive, not recruitingNCT00068224
30Fludarabine Phosphate, Melphalan, Total-Body Irradiation, Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Bone Marrow Failure DisordersActive, not recruitingNCT00856388
31Rare Genetic Disorders of the Breathing AirwaysActive, not recruitingNCT00323167
32Use Massive Parallel Sequencing and Exome Capture Technology to Sequence the Exome of Fanconi Anemia Children and Their PatentsAvailableNCT01995305
33Alefacept and Allogeneic Hematopoietic Stem Cell TransplantationSuspendedNCT01319851
34Tc-99m Renography and Cisplatin-induced NephrotoxicityTerminatedNCT00213642
35Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic CancerTerminatedNCT00290628

Search NIH Clinical Center for Renal Tubular Dysgenesis

Genetic Tests for Renal Tubular Dysgenesis

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Anatomical Context for Renal Tubular Dysgenesis

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MalaCards organs/tissues related to Renal Tubular Dysgenesis:

36
Kidney, Bone, Bone marrow, Liver, Lung, Fetal liver, Placenta

Publications for Renal Tubular Dysgenesis

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Articles related to Renal Tubular Dysgenesis:

(show top 50)    (show all 60)
idTitleAuthorsYear
1
Renal tubular dysgenesis: antenatal ultrasound scanning and molecular investigations in a Saudi Arabian family. (27994858)
2016
2
Renal function in angiotensinogen gene-mutated renal tubular dysgenesis with glomerular cysts. (25414114)
2015
3
Successful treatment of hemochromatosis with renal tubular dysgenesis in a preterm infant. (26331014)
2015
4
Renal tubular dysgenesis. (23636579)
2014
5
Recurrent massive perivillous fibrin deposition in the placenta associated with fetal renal tubular dysgenesis: case report and literature review. (23899317)
2013
6
Another case of concomitant fetal renal tubular dysgenesis and placental massive perivillous fibrin deposition. (24032745)
2013
7
Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis. (22095942)
2012
8
Survival over 2 years of autosomal-recessive renal tubular dysgenesis. (26069751)
2012
9
Impaired proteostasis contributes to renal tubular dysgenesis. (21695262)
2011
10
Renal tubular dysgenesis and tubulointerstitial nephritis antigen in juvenile nephronophthisis. (21265929)
2011
11
Renal tubular dysgenesis and reversible hypocalvaria after intrauterine exposure to an angiotensin receptor blocker. (25984140)
2011
12
Loss-of-function point mutations associated with renal tubular dysgenesis provide insights about renin function and cellular trafficking. (21036942)
2011
13
Renin-angiotensin system in kidney development: renal tubular dysgenesis. (19924102)
2010
14
Non-specific histopathological changes in kidney with renal tubular dysgenesis. (19616900)
2010
15
Inherited renal tubular dysgenesis may not be universally fatal. (20607303)
2010
16
Relationship of proximal renal tubular dysgenesis and fetal liver injury in neonatal hemochromatosis. (19809376)
2010
17
A further case of renal tubular dysgenesis surviving the neonatal period. (18478260)
2009
18
Renal tubular dysgenesis in Israel: pathologist's experience and literature review. (19344005)
2009
19
Congenital unilateral renal tubular dysgenesis and severe neonatal hypertension. (18982358)
2009
20
Inherited renal tubular dysgenesis: the first patients surviving the neonatal period. (17443344)
2008
21
Renal tubular dysgenesis: report of two cases in a non-consanguineous couple and review of the literature. (17003548)
2007
22
A case surviving for over a year of renal tubular dysgenesis with compound heterozygous angiotensinogen gene mutations. (17036344)
2006
23
Renal tubular dysgenesis with atypical histology and in-utero exposure to naproxen sodium. (16925962)
2006
24
Renal tubular dysgenesis associated with in utero exposure to Nimuselide. (16328538)
2006
25
Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: Role of the Renin-Angiotensin system. (16790508)
2006
26
Mutations in genes in the renin-angiotensin system are associated with autosomal recessive renal tubular dysgenesis. (16116425)
2005
27
Renal tubular dysgenesis with hypoplastic calvaria: report of two cases. (15517826)
2004
28
Renal tubular dysgenesis-a case presentation. (15641273)
2004
29
Renal tubular dysgenesis and neonatal hemochromatosis without pulmonary hypoplasia. (14677054)
2004
30
Renal tubular dysgenesis complicated with severe cranium hypoplasia. (15043673)
2004
31
Renal tubular dysgenesis in an hydropic fetus with trisomy 21: a case report with literature review. (15018458)
2003
32
Renal tubular dysgenesis and multiple intestinal perforation. (12447649)
2003
33
Renal tubular dysgenesis with medullary ray nodules. (12644933)
2003
34
Renal tubular dysgenesis. (12908566)
2003
35
Renal tubular dysgenesis in siblings. (12908573)
2003
36
Fibroepithelial bladder polyp and renal tubular dysgenesis: an unusual cause of third-trimester oligohydramnios. (11549150)
2001
37
Lysozyme immunostaining in renal tubular dysgenesis. (10679040)
2000
38
Renal tubular dysgenesis (RTD) - an important cause of the oligohydramnion-sequence. Report of 3 cases and review of the literature. (11156331)
2000
39
Renal tubular dysgenesis-like lesions and hypocalvaria. Report of two cases involving indomethacin. (11186177)
2000
40
Oxalate nephrocalcinosis in renal tubular dysgenesis. (10671031)
1999
41
Renal tubular dysgenesis in twin-twin transfusion syndrome. (9841703)
1999
42
Renal tubular dysgenesis, absent nipples, and multiple malformations in three brothers: a new, lethal syndrome. (9856560)
1998
43
Renal tubular dysgenesis in twins. (9686962)
1998
44
Neonatal hemochromatosis, renal tubular dysgenesis, and hypocalvaria in a neonate. (9688768)
1998
45
Renal tubular dysgenesis with microcephaly. (9260254)
1997
46
Renal tubular dysgenesis with calvarial hypoplasia: report of two additional cases and review. (9350819)
1997
47
Renal tubular dysgenesis: a cause of second trimester oligohydramnios. (9321784)
1997
48
Renal tubular dysgenesis: a report of two cases. (8979193)
1996
49
Familial renal tubular dysgenesis: a disorder not isolated to proximal convoluted tubules. (8705201)
1995
50
Labeled lectin studies of renal tubular dysgenesis and renal tubular atrophy of postnatal renal ischemia and end-stage kidney disease. (8159624)
1994

Variations for Renal Tubular Dysgenesis

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UniProtKB/Swiss-Prot genetic disease variations for Renal Tubular Dysgenesis:

70
id Symbol AA change Variation ID SNP ID
1AGTp.Arg375GlnVAR_035433rs74315283
2AGTR1p.Thr282MetVAR_035086rs104893677
3RENp.Arg230LysVAR_035087rs121917742
4RENp.Asp104AsnVAR_035088rs868694193

Clinvar genetic disease variations for Renal Tubular Dysgenesis:

5 (show all 19)
id Gene Variation Type Significance SNP ID Assembly Location
1RENNM_000537.3(REN): c.145C> T (p.Arg49Ter)SNVPathogenicrs121917741GRCh37Chr 1, 204131245: 204131245
2RENNM_000537.3(REN): c.689G> A (p.Arg230Lys)SNVPathogenicrs121917742GRCh37Chr 1, 204128527: 204128527
3ACENM_000789.3(ACE): c.798C> G (p.Tyr266Ter)SNVPathogenicrs121912704GRCh37Chr 17, 61557840: 61557840
4ACENM_000789.3(ACE): c.1319_1322delTGGA (p.Leu440Profs)deletionPathogenicrs387906576GRCh37Chr 17, 61560027: 61560030
5AGTR1NM_031850.3(AGTR1): c.*86A> CSNVrisk factorrs5186GRCh37Chr 3, 148459988: 148459988
6AGTR1NM_031850.3(AGTR1): c.215dupT (p.Ile73Hisfs)duplicationPathogenicrs387906577GRCh37Chr 3, 148458932: 148458932
7AGTR1NM_031850.3(AGTR1): c.950C> T (p.Thr317Met)SNVPathogenicrs104893677GRCh37Chr 3, 148459667: 148459667
8AGTNM_000029.3(AGT): c.803T> C (p.Met268Thr)SNVrisk factorrs699GRCh37Chr 1, 230845794: 230845794
9AGTNM_000029.3(AGT): c.1124G> A (p.Arg375Gln)SNVPathogenicrs74315283GRCh37Chr 1, 230841679: 230841679
10AGTNM_000029.3(AGT): c.604C> T (p.Gln202Ter)SNVPathogenicrs121912702GRCh37Chr 1, 230845993: 230845993
11AGTNM_000029.3(AGT): c.1290delT (p.Phe430Leufs)deletionPathogenicrs387906578GRCh37Chr 1, 230839055: 230839055
12ACENM_000789.3(ACE): c.12_31del20 (p.Ser5Alafs)deletionPathogenicrs797045079GRCh38Chr 17, 63477106: 63477125
13ACENM_000789.3(ACE): c.1522C> T (p.Arg508Ter)SNVLikely pathogenic, Pathogenicrs367797185GRCh37Chr 17, 61560855: 61560855
14AGTR1NM_031850.3(AGTR1): c.356G> A (p.Trp119Ter)SNVLikely pathogenic, Pathogenicrs398122935GRCh37Chr 3, 148459073: 148459073
15AGTR1NM_031850.3(AGTR1): c.481C> T (p.Arg161Ter)SNVPathogenicrs397514687GRCh37Chr 3, 148459198: 148459198
16ACENM_000789.3(ACE): c.1486C> T (p.Arg496Ter)SNVPathogenicrs397514688GRCh37Chr 17, 61560533: 61560533
17ACENM_000789.3(ACE): c.2371C> T (p.Arg791Ter)SNVPathogenicrs397514689GRCh37Chr 17, 61566074: 61566074
18RENNM_000537.3(REN): c.127C> T (p.Arg43Ter)SNVPathogenicrs397514690GRCh37Chr 1, 204131263: 204131263
19RENNM_000537.3(REN): c.404C> A (p.Ser135Tyr)SNVPathogenicrs397514691GRCh37Chr 1, 204129776: 204129776

Expression for genes affiliated with Renal Tubular Dysgenesis

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Search GEO for disease gene expression data for Renal Tubular Dysgenesis.

Pathways for genes affiliated with Renal Tubular Dysgenesis

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GO Terms for genes affiliated with Renal Tubular Dysgenesis

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Biological processes related to Renal Tubular Dysgenesis according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1blood vessel remodelingGO:000197410.1ACE, AGT
2positive regulation of protein tyrosine kinase activityGO:006109810.0ACE, AGT
3low-density lipoprotein particle remodelingGO:003437410.0AGT, AGTR1
4phospholipase C-activating G-protein coupled receptor signaling pathwayGO:000720010.0AGT, AGTR1
5positive regulation of cellular protein metabolic processGO:003227010.0AGT, AGTR1
6positive regulation of cholesterol esterificationGO:001087310.0AGT, AGTR1
7positive regulation of cytosolic calcium ion concentrationGO:000720410.0AGT, AGTR1
8positive regulation of inflammatory responseGO:00507299.9AGT, AGTR1
9positive regulation of macrophage derived foam cell differentiationGO:00107449.9AGT, AGTR1
10positive regulation of NAD(P)H oxidase activityGO:00338649.9AGT, AGTR1
11positive regulation of reactive oxygen species metabolic processGO:20003799.9AGT, AGTR1
12regulation of renal output by angiotensinGO:00020199.9ACE, AGT
13beta-amyloid metabolic processGO:00504359.8ACE, REN
14regulation of cell growthGO:00015589.8AGT, AGTR1
15regulation of renal sodium excretionGO:00358139.8AGT, AGTR1
16regulation of systemic arterial blood pressure by renin-angiotensinGO:00030819.8ACE, AGTR1
17regulation of blood volume by renin-angiotensinGO:00020169.7AGT, REN
18regulation of vasodilationGO:00423129.4ACE, AGTR1
19angiotensin maturationGO:00020039.3ACE, AGT, REN
20regulation of blood pressureGO:00082179.2ACE, AGT, REN
21regulation of vasoconstrictionGO:00192299.1ACE, AGT, AGTR1
22kidney developmentGO:00018228.7ACE, AGT, AGTR1, REN
23renin-angiotensin regulation of aldosterone productionGO:00020188.5AGT, AGTR1, REN

Molecular functions related to Renal Tubular Dysgenesis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.0ACE, AGTR1
2endopeptidase activityGO:00041759.8ACE, REN
3peptidase activityGO:00082339.1ACE, REN

Sources for Renal Tubular Dysgenesis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet