MCID: RNL022
MIFTS: 45

Renal Vascular Disease malady

Nephrological diseases, Cardiovascular diseases categories

Summaries for Renal Vascular Disease

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32MalaCards
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MalaCards: Renal Vascular Disease, also known as vascular disorder of kidney, is related to vascular disease and hypertension. An important gene associated with Renal Vascular Disease is MPV17 (MpV17 mitochondrial inner membrane protein), and among its related pathways is A-beta Uptake & Degradation. The compounds oxygen and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Renal Vascular Disease

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8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Cardiovascular diseases


Aliases & Descriptions:

renal vascular disease 8 10
vascular disorder of kidney 8
renal vascular disorder 60


External Ids:

Disease Ontology8 DOID:2388
NCIt39 C35338
ICD9CM27 593.81

Related Diseases for Renal Vascular Disease

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17GeneCards, 18GeneDecks
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Diseases related to Renal Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.2ACE, VEGFA, HSPD1, AGER, CTGF, HSPA8
2hypertension30.8MPV17, FBXL20, ALB, ACE
3diabetes mellitus30.3HSPD1, CTGF, FBXL20, VEGFA, AGER, ACE
4peripheral vascular disease30.2ACE, ALB
5essential hypertension30.2ALB, ACE, AGER
6obesity29.9AGER
7retinal vascular disease29.9CTGF, VEGFA
8retinal disease29.9AGER, ALB, VEGFA, CTGF, ACE
9renal hypertension10.6
10kidney disease10.2
11neurofibromatosis10.1
12end stage renal failure10.1
13renovascular hypertension10.0
14malignant hypertensive renal disease10.0
15aortic disease10.0
16malignant hypertension10.0
17retinitis10.0
18glaucoma10.0CTGF
19dementia10.0AGER
20pulmonary fibrosis10.0CTGF
21gingivitis10.0HSPD1
22kawasaki disease10.0HSPD1
23periodontitis10.0HSPD1
24chondrosarcoma10.0CTGF
25hepatitis10.0HSPD1
26infertility10.0HSPD1
27biliary atresia10.0CTGF
28gastritis10.0HSPD1
29cervicitis10.0HSPD1
30neuropathy10.0ALB
31crohn's disease10.0ALB
32connective tissue disease10.0ALB
33lupus nephritis10.0ALB
34brain edema10.0ALB
35graves' disease10.0HSPA8
36galactosemia10.0ALB
37rhinitis10.0ALB
38pancreatitis10.0ALB
39trachoma10.0HSPD1
40metabolic acidosis10.0ALB
41hepatopulmonary syndrome10.0ALB
42anuria10.0ACE
43hepatorenal syndrome10.0ALB
44dermatomyositis10.0HSPA8
45ulcerative colitis10.0ALB
46urinary tract obstruction10.0ACE
47cerebrovascular disease10.0ACE
48cholestasis10.0ALB
49paracoccidioidomycosis10.0HSPD1
50cataract10.0HSPD1, CTGF

Graphical network of the top 20 diseases related to Renal Vascular Disease:



Diseases related to renal vascular disease

Clinical Features for Renal Vascular Disease

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Drugs & Therapeutics for Renal Vascular Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Renal Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Renal Vascular Disease

Search NIH Clinical Center for Renal Vascular Disease

Search CenterWatch for Renal Vascular Disease

Genetic Tests for Renal Vascular Disease

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Anatomical Context for Renal Vascular Disease

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32MalaCards
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MalaCards organs/tissues related to Renal Vascular Disease:

32
Kidney, Endothelial, Testes, Pancreas, Bone, Heart, Smooth muscle

Animal Models for Renal Vascular Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renal Vascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.5AGER, VEGFA, ACE, ALB, MPV17
2MP:00053787.3ACE, HSPD1, CTGF, FBXL20, MPV17, AGER
3MP:00107686.9FBXL20, CTGF, HSPD1, MPV17, ACE, ALB

Publications for Renal Vascular Disease

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50PubMed
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Articles related to Renal Vascular Disease:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Effects of unfractionated heparin on renal osteodystrophy and vascular calcification in chronic kidney disease rats. (24145307)
2014
2
Management of peripheral vascular disease compromising renal allograft placement and function: review of the literature with an illustrative case. (21083763)
2011
3
Atherosclerotic Peripheral Vascular Disease Symposium II: intervention for renal artery disease. (19106410)
2008
4
Interaction of vascular and bone disease in patients with normal renal function and patients undergoing dialysis. (17180147)
2007
5
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism. (17560156)
2007
6
Functional polymorphisms in the vascular endothelial growth factor gene are associated with development of end-stage renal disease in males. (16421229)
2006
7
Controversial treatment of atherosclerotic renal vascular disease: the cardiovascular outcomes in renal atherosclerotic lesions trial. (16864748)
2006
8
Incidental renal artery stenosis is an independent predictor of mortality in patients with peripheral vascular disease. (16762991)
2006
9
Hyperphosphatemia and vascular calcification in end-stage renal disease. (15648030)
2005
10
Advanced glycation end products activate Smad signaling via TGF-beta-dependent and independent mechanisms: implications for diabetic renal and vascular disease. (12709399)
2004
11
Atherosclerotic ischemic renal vascular disease: do published outcomes justify the overzealous diagnostic approaches? (12838496)
2003
12
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 37-2003. A 79-year-old man with coronary artery disease, peripheral vascular disease, end-stage renal disease, and abdominal pain and distention. (14645643)
2003
13
Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. (12819233)
2003
14
Management of renal vascular disease in neurofibromatosis type 1 and the role of percutaneous transluminal angioplasty. (12105246)
2002
15
Peripheral vascular disease: perspectives on aortoiliac, renal, and femoral treatments using catheter-based techniques. (12053385)
2001
16
Incidental renal artery stenosis in peripheral vascular disease: a case for treatment? (11260411)
2001
17
Renal vascular disease: medical management, angioplasty, and stenting. (11022901)
2000
18
Elevated levels of circulating heat shock protein 70 (Hsp70) in peripheral and renal vascular disease. (11001481)
2000
19
Peripheral vascular disease and renal transplant artery stenosis: a reappraisal of transplant renovascular disease. (10485378)
1999
20
The role of hypertension, obesity, and diabetes in causing renal vascular disease. (10100692)
1999
21
Renal vascular disease in the elderly. (9839288)
1998
22
Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma. (9893759)
1998
23
Survival in renal vascular disease. (9527401)
1998
24
A patient centered approach to the treatment of renal vascular disease to prevent end stage renal failure. (9422700)
1997
25
The use of kidneys from living donors with renal vascular disease: expanding the donor pool. (9112482)
1997
26
Prevalence of renal artery stenosis in patients with peripheral vascular disease and hypertension. (8867560)
1996
27
Homocysteinemia and vascular disease in end-stage renal disease. (8941916)
1996
28
Expression of receptors for advanced glycation end-products in occlusive vascular and renal disease. (9044315)
1996
29
Progression of occlusive renal vascular disease and axillofemoral bypass grafts. (8272243)
1993
30
Renal vascular disease in patients with primary antiphospholipid antibodies. (8302471)
1993
31
Albuminuria--a marker of renal and generalized vascular disease in insulin-dependent diabetes mellitus. (2060321)
1991
32
Diagnosis and treatment of renal vascular disease. (2300217)
1990
33
Evaluation of mesenteric and renal vascular disease. (2182093)
1990
34
Renal artery stenosis and peripheral vascular disease: implications for ACE inhibitor therapy. (1974015)
1990
35
Critical perfusion pressure for renal function in patients with bilateral atherosclerotic renal vascular disease. (3970470)
1985
36
Renal vascular disease: pathology of large blood vessel disease. (3887907)
1985
37
Peripheral renal vascular disease in essential hypertension: hemodynamic, angiographic, and endocrine assessment. (6388838)
1984
38
Aortic and renal vascular disease. Factors affecting the value of combined procedures. (6465984)
1984
39
Renal vascular disease and renovascular hypertension in children. (6235660)
1984
40
Influence of neonatal thymectomy on blood pressure and hypertensive vascular disease in rats with renal hypertension. (1096529)
1975
41
Atherosclerotic renal vascular disease. Diagnosis and treatment. (4865638)
1968
42
A study of the renal vascular patterns in hypertension, chronic pyelonephritis and other diseases. Hunterian Lecture delivered at the Royal College of Surgeons of England on 24th February 1966. (6021560)
1967
43
THE PHONORENOGRAM: TRANSURETERAL PHONOCATHETER RECORDING OF THE RENAL ARTERY PULSE IN THE DIAGNOSIS OF RENAL VASCULAR DISEASE. (14226461)
1964
44
HYPERTENSION DUE TO UNILATERAL RENAL VASCULAR DISEASE. (14228117)
1964
45
OCCLUSIVE VASCULAR DISEASE INCLUDING RENAL ARTERY OBSTRUCTION--TREATMENT AND PROGNOSIS. (15446155)
1964
46
RENAL VASCULAR DISEASE. (14328536)
1964
47
Differential excretion studies in the evaluation of unilateral renal vascular disease. (13881077)
1962
48
Diagnosis of renal vascular disease and renal tumors by photoscanning. (13905680)
1962
49
Diagnosis of renal vascular disease. (14476244)
1962
50
Renal vascular disease in diabetes mellitus. (13107537)
1953

Genetic Variations for Renal Vascular Disease

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Expression for genes affiliated with Renal Vascular Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renal Vascular Disease

Search GEO for disease gene expression data for Renal Vascular Disease.

Pathways for genes affiliated with Renal Vascular Disease

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52R&D Systems
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Pathways related to Renal Vascular Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ACE, AGER

Compounds for genes affiliated with Renal Vascular Disease

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Sources:
44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
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Compounds related to Renal Vascular Disease according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1oxygen44 2411.5MPV17
2captopril44 28 49 59 1114.5CTGF
3glucose4410.1CTGF, HSPA8
4alpha tocopherol4410.0HSPA8, CTGF
5kallidin44 2811.0ACE, CTGF
6olmesartan44 28 1112.0AGER, ACE
7cdcl2449.9HSPD1, HSPA8
8n(epsilon)-(carboxymethyl)lysine449.7AGER, ALB
9losartan44 49 28 1112.7ALB, CTGF
10pentosidine449.7AGER, ALB
11mannitol44 1110.6ALB, HSPA8
12nifedipine44 49 28 1112.6ACE, AGER, CTGF
13indapamide44 1110.5ACE, ALB
14fosinopril44 1110.5ACE, ALB
15glyceraldehyde 3-phosphate449.5CTGF, HSPD1, HSPA8
16ramipril44 1110.4ALB, ACE
17Vandetanib119.4ALB, VEGFA
18valsartan44 59 28 1112.4ACE, ALB
19ang ii449.4ACE, VEGFA, CTGF
20simvastatin44 49 59 28 11 2414.4HSPA8, CTGF, VEGFA
21irbesartan44 28 49 1112.3ALB, ACE
22curcumin449.3HSPA8, CTGF, VEGFA
23hydrochlorothiazide44 49 28 11 2413.3ALB, ACE
24gliclazide44 49 1111.3ALB, VEGFA
25enalapril44 49 1111.3ACE, ALB
26arsenite44 2410.3VEGFA, HSPD1, HSPA8
27spironolactone49 44 59 28 1113.2ALB, ACE
28ribonucleic acid449.2CTGF, HSPD1, HSPA8
29carvedilol44 49 28 1112.2VEGFA, ACE
30telmisartan44 28 1111.2AGER, ACE, ALB
31amlodipine44 49 11 2412.2ALB, ACE
32heparin44 28 11 2412.1HSPA8, CTGF, AGER, VEGFA
33radicicol44 59 1111.1VEGFA, HSPA8
34prostacyclin449.0CTGF, AGER, VEGFA, ACE
35lisinopril44 11 2410.9VEGFA, ACE, ALB
36perindopril44 49 1110.9VEGFA, ACE, ALB
37imatinib44 49 1110.9ALB, VEGFA, HSPA8
38nitric oxide44 11 2410.8ACE, AGER, CTGF, HSPA8
39lactate448.8HSPA8, HSPD1, CTGF, ALB
40n acetylcysteine448.7VEGFA, AGER, CTGF, HSPD1, HSPA8
41vegf448.7VEGFA, AGER, CTGF, HSPD1, HSPA8
42candesartan44 28 1110.6ALB, ACE, VEGFA, AGER
43cholesterol44 28 11 2411.3HSPA8, HSPD1, AGER, ACE, ALB
44creatinine448.0HSPA8, HSPD1, CTGF, AGER, ACE, ALB
45lipid448.0HSPA8, HSPD1, CTGF, AGER, ACE, ALB
46calcium44 49 11 2410.8HSPA8, HSPD1, CTGF, AGER, ACE, ALB

GO Terms for genes affiliated with Renal Vascular Disease

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16Gene Ontology
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Cellular components related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8AGER, VEGFA, ACE, ALB, CTGF
2extracellular spaceGO:0056157.4ALB, ACE, VEGFA, CTGF, HSPD1

Biological processes related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1reactive oxygen species metabolic processGO:0725939.8MPV17, CTGF
2induction of positive chemotaxisGO:0509309.2VEGFA, AGER

Molecular functions related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.5VEGFA, CTGF

Products for genes affiliated with Renal Vascular Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renal Vascular Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet