MCID: RNL022
MIFTS: 45

Renal Vascular Disease malady

Nephrological diseases, Cardiovascular diseases categories

Summaries for Renal Vascular Disease

About this section
Sources:
32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MalaCards: Renal Vascular Disease, also known as vascular disorder of kidney, is related to vascular disease and hypertension. An important gene associated with Renal Vascular Disease is MPV17 (MpV17 mitochondrial inner membrane protein), and among its related pathways is A-beta Uptake & Degradation. The compounds oxygen and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and pancreas, and related mouse phenotypes are renal/urinary system and growth/size.

Aliases & Classifications for Renal Vascular Disease

About this section
Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological diseases, Cardiovascular diseases


Aliases & Descriptions:

renal vascular disease 8 10
vascular disorder of kidney 8
renal vascular disorder 60


External Ids:

Disease Ontology8 DOID:2388
NCIt39 C35338
ICD9CM27 593.81

Related Diseases for Renal Vascular Disease

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Renal Vascular Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease31.2ACE, VEGFA, HSPD1, AGER, CTGF, HSPA8
2hypertension30.8MPV17, FBXL20, ALB, ACE
3diabetes mellitus30.3HSPD1, CTGF, FBXL20, VEGFA, AGER, ACE
4peripheral vascular disease30.2ACE, ALB
5essential hypertension30.2ALB, ACE, AGER
6obesity29.9AGER
7retinal vascular disease29.9CTGF, VEGFA
8retinal disease29.9AGER, ALB, VEGFA, CTGF, ACE
9renal hypertension10.6
10kidney disease10.2
11neurofibromatosis10.1
12end stage renal failure10.1
13renovascular hypertension10.0
14malignant hypertensive renal disease10.0
15aortic disease10.0
16malignant hypertension10.0
17retinitis10.0
18glaucoma10.0CTGF
19dementia10.0AGER
20pulmonary fibrosis10.0CTGF
21gingivitis10.0HSPD1
22kawasaki disease10.0HSPD1
23periodontitis10.0HSPD1
24chondrosarcoma10.0CTGF
25hepatitis10.0HSPD1
26infertility10.0HSPD1
27biliary atresia10.0CTGF
28gastritis10.0HSPD1
29cervicitis10.0HSPD1
30neuropathy10.0ALB
31crohn's disease10.0ALB
32connective tissue disease10.0ALB
33lupus nephritis10.0ALB
34brain edema10.0ALB
35graves' disease10.0HSPA8
36galactosemia10.0ALB
37rhinitis10.0ALB
38pancreatitis10.0ALB
39trachoma10.0HSPD1
40metabolic acidosis10.0ALB
41hepatopulmonary syndrome10.0ALB
42anuria10.0ACE
43hepatorenal syndrome10.0ALB
44dermatomyositis10.0HSPA8
45ulcerative colitis10.0ALB
46urinary tract obstruction10.0ACE
47cerebrovascular disease10.0ACE
48cholestasis10.0ALB
49paracoccidioidomycosis10.0HSPD1
50cataract10.0HSPD1, CTGF

Graphical network of the top 20 diseases related to Renal Vascular Disease:



Diseases related to renal vascular disease

Clinical Features for Renal Vascular Disease

About this section

Drugs & Therapeutics for Renal Vascular Disease

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Renal Vascular Disease

Drug clinical trials:

Search ClinicalTrials for Renal Vascular Disease

Search NIH Clinical Center for Renal Vascular Disease

Search CenterWatch for Renal Vascular Disease

Genetic Tests for Renal Vascular Disease

About this section

Anatomical Context for Renal Vascular Disease

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Renal Vascular Disease:

32
Kidney, Endothelial, Pancreas, Testes, Bone, Heart, Smooth muscle

Animal Models for Renal Vascular Disease or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Renal Vascular Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053677.5MPV17, AGER, VEGFA, ACE, ALB
2MP:00053787.3ACE, VEGFA, AGER, MPV17, FBXL20, CTGF
3MP:00107686.9ALB, ACE, VEGFA, MPV17, FBXL20, CTGF

Publications for Renal Vascular Disease

About this section
Sources:
50PubMed
See all sources

Articles related to Renal Vascular Disease:

(show top 50)    (show all 123)
idTitleAuthorsYear
1
Effect of peripheral vascular disease on kidney allograft outcomes: a study of U.S. Renal data system. (23354295)
2013
2
Male sex and vascular risk factors affect cystatin C-derived renal function in older people without diabetes or overt vascular disease. (24321840)
2013
3
Vascular endothelial growth factor gene polymorphisms in North Indian patients with end stage renal disease. (22370607)
2012
4
Should peripheral vascular disease- or diabetes-related amputation contraindicate renal transplant? (22787569)
2012
5
Superficial temporal artery calcification in patients with end-stage renal disease: Association with vascular risk factors and ischemic cerebrovascular disease. (22013298)
2011
6
Surgically unresectable regional melanoma metastases in a patient with renal failure and peripheral vascular disease: are there safe and potentially effective treatments? (20816500)
2010
7
CT-guided radiofrequency ablation of a renal tumor abutting vascular pedicle in a patient with von Hippel Lindau disease. (19067041)
2009
8
Renal vascular disease: a vexing challenge for the clinician. (19917328)
2009
9
IL-18 is involved in vascular injury in end-stage renal disease patients. (18775894)
2009
10
Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes. (18319310)
2008
11
Effect of statin treatment on renal function and serum uric acid levels and their relation to vascular events in patients with coronary heart disease and metabolic syndrome: a subgroup analysis of the GREek Atorvastatin and Coronary heart disease Evaluation (GREACE) Study. (16998214)
2007
12
Osteopontin expression in vascular smooth muscle cells in patients with end-stage renal disease. (16817793)
2006
13
Hypertensive renal vascular disease and cardiovascular endpoints. (16755198)
2006
14
Vascular calcification and renal osteodystrophy relationship in chronic kidney disease. (16884398)
2006
15
Eicosanoids and renal vascular function in diseases. (16764555)
2006
16
Occult renal impairment is common in patients with peripheral vascular disease and normal serum creatinine. (16716614)
2006
17
Renal artery stenosis in patients with peripheral vascular disease in Kuwait. (16220010)
2005
18
Mechanisms of vascular calcification in renal disease. (15730057)
2005
19
Multicentric Castleman's disease associated with glomerular microangiopathy and MPGN-like lesion: does vascular endothelial cell-derived growth factor play causative or protective roles in renal injury? (14712466)
2004
20
The impact of gender on progression of renal disease: potential role of estrogen-mediated vascular endothelial growth factor regulation and vascular protection. (14742271)
2004
21
Vascular calcification in end stage renal disease]. (15775441)
2002
22
Mineral metabolism and vascular disease in patients with end-stage renal failure. (12169065)
2002
23
Interobserver agreement on captopril renography for assessing renal vascular disease. (11884492)
2002
24
Blunted vascular and renal effects of exogenous atrial natriuretic peptide in patients with cushing's disease. (11344191)
2001
25
Dyslipidemia and hypertension: twin killers in renal vascular disease. (11382708)
2001
26
Peripheral vascular disease intervention in patients with end-stage renal disease: few complications in those treated with peritoneal dialysis. (11702811)
2001
27
Long-term outcomes of revascularization for peripheral vascular disease in end-stage renal disease patients. (11431182)
2001
28
Vascular endothelial markers, von Willebrand factor and thrombomodulin index, are specifically elevated in type 2 diabetic patients with nephropathy: comparison of primary renal disease. (10900293)
2000
29
Rationale, design, and baseline characteristics of a trial of prevention of cardiovascular and renal disease with fosinopril and pravastatin in nonhypertensive, nonhypercholesterolemic subjects with microalbuminuria (the Prevention of REnal and Vascular ENdstage Disease Intervention Trial [PREVEND IT]). (10980214)
2000
30
Diagnosis of renal vascular disease with MR angiography. (10555673)
1999
31
Impact of kidney-pancreas transplantation on the progression of peripheral vascular disease in diabetic patients with end-stage renal disease. (9723347)
1998
32
Kidneys from living donors with renal vascular disease may be safely used for transplantation. (9414766)
1997
33
Progression of peripheral vascular disease after combined kidney-pancreas transplantation in diabetic patients with end-stage renal failure. (9123467)
1997
34
Renal vascular lesions in the elderly: nephrosclerosis or atheromatous renal disease? (9050035)
1996
35
Expression of vascular endothelial growth factor in renal vascular disease and renal allografts. (8551388)
1995
36
Differences in hormonal and renal vascular responses between normotensive patients with autosomal dominant polycystic kidney disease and unaffected family members. (7861706)
1994
37
Tests for renal vascular disease. (1353842)
1992
38
Recurrent thrombosis and renal vascular disease in patients with a lupus anticoagulant. (2515488)
1989
39
Renal vascular disease in diabetes mellitus. (3286470)
1988
40
Peripheral renal vascular disease in essential hypertension: hemodynamic, angiographic, and endocrine assessment. (6388838)
1984
41
Trends in reconstruction for atherosclerotic renal vascular disease. (6507762)
1984
42
Surgical treatment of unilateral renal vascular disease. Prognostic role of vascular changes in bilateral renal biopsies. (4634280)
1972
43
Atherosclerotic renal vascular disease. Diagnosis and treatment. (4865638)
1968
44
Renal vascular disease associated with diabetes mellitus. (6039852)
1967
45
Diagnostic investigation of hypertensive patients with suspected unilateral renal vascular disease. (13951997)
1963
46
Renal vascular disease as a cause of hypertension. (13872876)
1962
47
Critical appraisal of the renogram in renal vascular disease. (13917113)
1962
48
Renal scintiscans in the diagnosis of renal vascular disease. (13905681)
1961
49
Hypophysectomy in unstable diabetics with progressive retinal and renal vascular disease. (13404394)
1957
50
Hypertension resulting from unilateral renal vascular disease and its relief by nephrectomy. (13126725)
1954

Genetic Variations for Renal Vascular Disease

About this section

Expression for genes affiliated with Renal Vascular Disease

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Renal Vascular Disease

Search GEO for disease gene expression data for Renal Vascular Disease.

Pathways for genes affiliated with Renal Vascular Disease

About this section
Sources:
52R&D Systems
See all sources

Pathways related to Renal Vascular Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6ACE, AGER

Compounds for genes affiliated with Renal Vascular Disease

About this section
Sources:
44Novoseek, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience, 11DrugBank
See all sources

Compounds related to Renal Vascular Disease according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1oxygen44 2411.5MPV17
2captopril44 28 49 59 1114.5CTGF
3glucose4410.1CTGF, HSPA8
4alpha tocopherol4410.0HSPA8, CTGF
5kallidin44 2811.0ACE, CTGF
6olmesartan44 28 1112.0AGER, ACE
7cdcl2449.9HSPD1, HSPA8
8n(epsilon)-(carboxymethyl)lysine449.7AGER, ALB
9losartan44 49 28 1112.7ALB, CTGF
10pentosidine449.7AGER, ALB
11mannitol44 1110.6ALB, HSPA8
12nifedipine44 49 28 1112.6ACE, AGER, CTGF
13indapamide44 1110.5ACE, ALB
14fosinopril44 1110.5ACE, ALB
15glyceraldehyde 3-phosphate449.5CTGF, HSPD1, HSPA8
16ramipril44 1110.4ALB, ACE
17Vandetanib119.4ALB, VEGFA
18valsartan44 59 28 1112.4ACE, ALB
19ang ii449.4ACE, VEGFA, CTGF
20simvastatin44 49 59 28 11 2414.4HSPA8, CTGF, VEGFA
21irbesartan44 28 49 1112.3ALB, ACE
22curcumin449.3HSPA8, CTGF, VEGFA
23hydrochlorothiazide44 49 28 11 2413.3ALB, ACE
24gliclazide44 49 1111.3ALB, VEGFA
25enalapril44 49 1111.3ACE, ALB
26arsenite44 2410.3VEGFA, HSPD1, HSPA8
27spironolactone49 44 59 28 1113.2ALB, ACE
28ribonucleic acid449.2CTGF, HSPD1, HSPA8
29carvedilol44 49 28 1112.2VEGFA, ACE
30telmisartan44 28 1111.2AGER, ACE, ALB
31amlodipine44 49 11 2412.2ALB, ACE
32heparin44 28 11 2412.1HSPA8, CTGF, AGER, VEGFA
33radicicol44 59 1111.1VEGFA, HSPA8
34prostacyclin449.0CTGF, AGER, VEGFA, ACE
35lisinopril44 11 2410.9VEGFA, ACE, ALB
36perindopril44 49 1110.9VEGFA, ACE, ALB
37imatinib44 49 1110.9ALB, VEGFA, HSPA8
38nitric oxide44 11 2410.8ACE, AGER, CTGF, HSPA8
39lactate448.8HSPA8, HSPD1, CTGF, ALB
40n acetylcysteine448.7VEGFA, AGER, CTGF, HSPD1, HSPA8
41vegf448.7VEGFA, AGER, CTGF, HSPD1, HSPA8
42candesartan44 28 1110.6ALB, ACE, VEGFA, AGER
43cholesterol44 28 11 2411.3HSPA8, HSPD1, AGER, ACE, ALB
44creatinine448.0HSPA8, HSPD1, CTGF, AGER, ACE, ALB
45lipid448.0HSPA8, HSPD1, CTGF, AGER, ACE, ALB
46calcium44 49 11 2410.8HSPA8, HSPD1, CTGF, AGER, ACE, ALB

GO Terms for genes affiliated with Renal Vascular Disease

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.8AGER, VEGFA, ACE, ALB, CTGF
2extracellular spaceGO:0056157.4ALB, ACE, VEGFA, CTGF, HSPD1

Biological processes related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1reactive oxygen species metabolic processGO:0725939.8MPV17, CTGF
2induction of positive chemotaxisGO:0509309.2VEGFA, AGER

Molecular functions related to Renal Vascular Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:0019689.5VEGFA, CTGF

Products for genes affiliated with Renal Vascular Disease

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renal Vascular Disease

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet