MCID: RNV001
MIFTS: 47

Renovascular Hypertension malady

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renovascular Hypertension

Aliases & Descriptions for Renovascular Hypertension:

Name: Renovascular Hypertension 12 14
Hypertension, Renovascular 42 69
Hypertension Renovascular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1591
ICD10 33 I15.0
MeSH 42 D006978
NCIt 47 C85044
SNOMED-CT 64 123799005 194790006
UMLS 69 C0020545

Summaries for Renovascular Hypertension

MalaCards based summary : Renovascular Hypertension, also known as hypertension, renovascular, is related to malignant renovascular hypertension and benign renovascular hypertension. An important gene associated with Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Peptide hormone metabolism and MicroRNAs in cardiomyocyte hypertrophy. The drugs Antihypertensive Agents and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 Renovascular hypertension (or \"renal hypertension\") is a condition in which high blood pressure is... more...

Related Diseases for Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 malignant renovascular hypertension 12.2
2 benign renovascular hypertension 12.0
3 uterine inflammatory disease 10.3 EDN1 REN
4 hypotrichosis simplex 10.3 ACE REN
5 hyperinsulinemic hypoglycemia, familial, 3 10.3 ACE REN
6 carbohydrate metabolic disorder 10.3 ACE REN
7 hypothyroidism, congenital nongoitrous, 5 10.3 ACE REN
8 hepatic infarction 10.3 EDN1 REN
9 listeriosis 10.3 ACE REN
10 dientamoebiasis 10.3 ACE REN
11 adenocarcinoma 10.3 EDN1 REN
12 endotheliitis 10.3
13 proliferating trichilemmal cyst 10.3 EDN1 NOS3
14 congenital nystagmus 10.3 ACE REN
15 shaken baby syndrome 10.3 NPPA REN
16 kartagener syndrome 10.2 ACE NOS3
17 achromatopsia 10.2 NPPA REN
18 blackwater fever 10.2 EDN1 NPPA
19 indeterminate leprosy 10.2 EDN1 NOS3
20 fibromuscular dysplasia 10.2
21 chylocele of tunica vaginalis 10.2 ACE REN
22 hypogonadism mitral valve prolapse mental retardation 10.2 ACE NPPA REN
23 chronic inflammatory demyelinating polyneuropathy 10.2 NPPB REN
24 high-grade dysplasia in patients with barrett esophagus 10.2 EDN1 NPPA REN
25 bullous skin disease 10.2 ACE HMOX1
26 pythiosis 10.2 ACE NPPA REN
27 capillary hemangioma 10.2 EDN1 NOS3 REN
28 aphasia 10.2 ACE EDN1 NOS3
29 oppositional defiant disorder 10.1 ACE EDN1 NOS3
30 gastrointestinal lymphoma 10.1 ACE NOS3 REN
31 citrulline transport defect 10.1 EDN1 NPPB
32 rapidly progressive glomerulonephritis 10.1 ACE NOS3 NPPA
33 viral hepatitis 10.1 ACE EDN1 NOS3
34 peroneal neuropathy 10.1 ACE NOS3 REN
35 hemorrhoid 10.1 EDN1 REN
36 body dysmorphic disorder 10.1 ACE NOS3 REN
37 lymphoblastic lymphoma 10.1 EDN1 NPPA REN
38 autonomic neuropathy 10.1 NPPB REN
39 aneurysm 10.1
40 zellweger syndrome 10.1 EDN1 HMOX1 NOS3
41 neurofibromatosis 10.1
42 takayasu arteritis 10.1
43 vitreous disease 10.1 NOS3 NPPB
44 myopia 10.1 ACE EDN1 NPPA REN
45 autoimmune-related retinopathy and optic neuropathy 10.1 ACE EDN1 NOS3
46 ischemia 10.1
47 limb ischemia 10.1 ACE EDN1 NOS3 REN
48 deafness, autosomal recessive 79 10.1 ACE NPPB REN
49 inferolateral myocardial infarct 10.1 ACE NPPA NPPB
50 urinary bladder posterior wall cancer 10.0 NPPA NPPB REN

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to Renovascular Hypertension

Symptoms & Phenotypes for Renovascular Hypertension

MGI Mouse Phenotypes related to Renovascular Hypertension:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.09 REN ACE ADM AGTR1 EDN1 HMOX1
2 hematopoietic system MP:0005397 10.02 ACE ADM AGTR1 CMA1 HMOX1 NF1
3 homeostasis/metabolism MP:0005376 9.97 ACE ADM AGTR1 EDN1 HMOX1 NF1
4 endocrine/exocrine gland MP:0005379 9.88 ACE ADM EDN1 HMOX1 NF1 NOS3
5 immune system MP:0005387 9.86 AGTR1 CMA1 HMOX1 NF1 NOS3 REN
6 liver/biliary system MP:0005370 9.55 ACE ADM HMOX1 NF1 NOS3
7 muscle MP:0005369 9.5 ADM EDN1 HMOX1 NF1 NOS3 NPPA
8 renal/urinary system MP:0005367 9.28 ACE ADM AGTR1 EDN1 HMOX1 NF1

Drugs & Therapeutics for Renovascular Hypertension

Drugs for Renovascular Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 4,Phase 3
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
3
Amlodipine Approved Phase 3 88150-42-9 2162
4
Candesartan Approved Phase 3 139481-59-7 2541
5
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
6 Amlodipine, atorvastatin drug combination Phase 3
7
Angiotensin II Phase 3 68521-88-0, 11128-99-7 65143 172198
8 Angiotensin II Type 1 Receptor Blockers Phase 3
9 Angiotensin Receptor Antagonists Phase 3
10 Angiotensinogen Phase 3
11 Anticholesteremic Agents Phase 3
12 Antimetabolites Phase 3
13 Atorvastatin Calcium Phase 3 134523-03-8
14 calcium channel blockers Phase 3
15 Calcium, Dietary Phase 3
16
Candesartan cilexetil Phase 3 145040-37-5 2540
17 Hypolipidemic Agents Phase 3
18 Lipid Regulating Agents Phase 3
19 Analgesics Phase 3
20 Analgesics, Non-Narcotic Phase 3
21 Anti-Inflammatory Agents Phase 3
22 Anti-Inflammatory Agents, Non-Steroidal Phase 3
23 Antirheumatic Agents Phase 3
24 Cyclooxygenase 2 Inhibitors Phase 3
25 Cyclooxygenase Inhibitors Phase 3
26 Peripheral Nervous System Agents Phase 3
27 Vasodilator Agents Phase 3
28
Amiloride Approved 2016-88-8, 2609-46-3 16231
29
Spironolactone Approved 1952-01-7, 52-01-7 5833
30
Heparin Approved, Investigational 9005-49-6 772 46507594
31
Lidocaine Approved, Vet_approved 137-58-6 3676
32 diuretics
33 Diuretics, Potassium Sparing
34 Epithelial Sodium Channel Blockers
35 Hormone Antagonists
36 Hormones
37 Hormones, Hormone Substitutes, and Hormone Antagonists
38 Mineralocorticoid Receptor Antagonists
39 Mineralocorticoids
40 Natriuretic Agents
41 Sodium Channel Blockers
42 Angiotensin-Converting Enzyme Inhibitors
43 Anesthetics
44 Anesthetics, Local
45 calcium heparin
46 Fibrinolytic Agents
47 Pharmaceutical Solutions
48 Adrenergic beta-Antagonists

Interventional clinical trials:

(show all 21)
id Name Status NCT ID Phase
1 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4
2 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
3 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed NCT00081731 Phase 3
4 Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives Recruiting NCT02979197 Phase 3
5 Study to Assess the Effects of Intravenous Bendavia in Patients Undergoing Percutaneous Transluminal Angioplasty of the Renal Artery (PTRA) Terminated NCT01755858 Phase 1, Phase 2
6 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
7 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Recruiting NCT02266394 Phase 1
8 MSC for Occlusive Disease of the Kidney Active, not recruiting NCT01840540 Phase 1
9 Magnetic Resonance Imaging for Evaluating Kidney Function Completed NCT00006173
10 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738
11 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
12 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540
13 The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables Completed NCT01195805
14 Telehealth & Remote Measurement Technologies to Improve Medication Adherence in Hypertension Completed NCT01439256
15 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
16 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Recruiting NCT01673373
17 Cardiovascular, Renal and Metabolic Profile in Patients With Acute Myocardial Infarction (REN-ACS) Recruiting NCT02388139
18 Evaluation of Patients With Heart Disease Not Eligible for Research Protocols Recruiting NCT00001458
19 IntErnational Long-term Follow-up Study of Patients With Uncontrolled HyperTensioN Active, not recruiting NCT01705080
20 A Feasibility Study to Evaluate the Effect of Concomitant Renal Denervation and Cardiac Ablation on AF Recurrence Active, not recruiting NCT01907828
21 Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypertension, renovascular

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

MalaCards organs/tissues related to Renovascular Hypertension:

39
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes

Publications for Renovascular Hypertension

Articles related to Renovascular Hypertension:

(show top 50) (show all 649)
id Title Authors Year
1
Complex glomerular pathology of thrombotic microangiopathy and focal segmental glomerulosclerosis forms tumor-like mass in a renal transplant donor with severe renovascular hypertension. ( 28509120 )
2017
2
Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension. ( 27078869 )
2016
3
Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension. ( 27625610 )
2016
4
Imperatorin derivative OW1 inhibits the upregulation of TGF-I^ and MMP-2 in renovascular hypertension-induced cardiac remodeling. ( 27168797 )
2016
5
Management of Renovascular Hypertension. ( 27641455 )
2016
6
Infantile Renovascular Hypertension with Failure to Thrive. ( 26965798 )
2016
7
Takayasu arteritis associated with severe renovascular hypertension. ( 26997400 )
2016
8
Antagonism of endothelin (ETA and ETB) receptors during renovascular hypertension-induced vascular dementia improves cognition. ( 27189349 )
2016
9
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus. ( 27881877 )
2016
10
Aliskiren and l-arginine treatments restore depressed baroreflex sensitivity and decrease oxidative stress in renovascular hypertension rats. ( 27383506 )
2016
11
Percutaneous Transluminal Angioplasty Improved Posterior Reversible Encephalopathy Syndrome due to Renovascular Hypertension. ( 26646732 )
2016
12
Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension. ( 26661648 )
2016
13
Cardiovascular manifestations of renovascular hypertension in diabetic mice. ( 26925344 )
2016
14
Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension. ( 27602985 )
2016
15
OS 11-03 Role of renal nervous activity in the development of renovascular hypertension in rats. ( 27753970 )
2016
16
Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature. ( 27041160 )
2016
17
Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats. ( 27010894 )
2016
18
Large retroperitoneal immature teratoma leading to renovascular hypertension. ( 28008730 )
2016
19
Novel insights into renovascular hypertension and cardio-renal protection by iron restriction. ( 27604341 )
2016
20
Hypercholesterolemia Impairs Nonstenotic Kidney Outcomes After Reversal of Experimental Renovascular Hypertension. ( 26739189 )
2016
21
Renovascular hypertension: Effects of mesenchymal stem cells in the contralateral hypertensive kidney in rats. ( 27649588 )
2016
22
Outcomes of percutaneous transluminal angioplasty for pediatric renovascular hypertension. ( 27634559 )
2016
23
BehAset's Disease Presenting as Renovascular Hypertension Treated Successfully With Percutaneous Angioplasty. ( 27916225 )
2016
24
Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension. ( 26764145 )
2016
25
OS 11-03 Role of renal nervous activity in the development of renovascular hypertension in rats. ( 27643367 )
2016
26
Non-invasive imaging cannot replace formal angiography in the diagnosis of renovascular hypertension. ( 27747454 )
2016
27
Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat. ( 26920631 )
2016
28
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats. ( 27510951 )
2016
29
Prior renovascular hypertension does not predispose to atherosclerosis in mice. ( 27100924 )
2016
30
Decreased immunoreactivity of visfatin in the pancreas and liver of rats with renovascular hypertension. ( 28078856 )
2016
31
Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension. ( 27399230 )
2016
32
Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension. ( 27247333 )
2016
33
Selective stent placement versus balloon angioplasty for renovascular hypertension caused by Takayasu arteritis: Two-year results. ( 26730842 )
2016
34
Attenuation of renovascular hypertension by cyclooxygenase-2 inhibitor partly through ANP release. ( 25846103 )
2015
35
Influence of renovascular hypertension on the distribution of vasoactive intestinal peptide in the stomach and heart of rats. ( 25990439 )
2015
36
Iliac artery obliteration as a cause of renovascular hypertension in kidney graft recipients: A difficult and uncommon diagnosis. ( 26306960 )
2015
37
Angioplasty for renovascular hypertension in 78 children. ( 25527520 )
2015
38
Sildenafil Improves Vascular Endothelial Structure and Function in Renovascular Hypertension. ( 26059106 )
2015
39
Brain Stem Hemorrhage in a 2-Year-10-Month-Old Child with Renovascular Hypertension Related to Fibromuscular Dysplasia. ( 27122924 )
2015
40
Combined aliskiren and L-arginine treatment has antihypertensive effects and prevents vascular endothelial dysfunction in a model of renovascular hypertension. ( 25493385 )
2015
41
Combined Aliskiren and L-arginine treatment reverses renovascular hypertension in an animal model. ( 25740291 )
2015
42
Quantitative evaluation of CART-containing cells in urinary bladder of rats with renovascular hypertension. ( 26150151 )
2015
43
Detection of Segmental Renal Ischemia by Diffusion-Weighted Magnetic Resonance Imaging: Clinical Utility for Diagnosis of Renovascular Hypertension. ( 26360321 )
2015
44
Effect of naringin on hemodynamic changes and left ventricular function in renal artery occluded renovascular hypertension in rats. ( 25883516 )
2015
45
Aldosterone Contributes to Sympathoexcitation in Renovascular Hypertension. ( 25628418 )
2015
46
Effects of mesenchymal stem cells in renovascular hypertension. ( 25605443 )
2015
47
Impact of Small Renal Ischemia in Hypertension Development: Renovascular Hypertension Caused by Small Branch Artery Stenosis. ( 26293888 )
2015
48
Associated extrarenal vascular diseases may complicate the treatment andA outcome of renovascular hypertension. ( 26437121 )
2015
49
Retrograde Renal Ablation via the Renal Vein as a New Treatment Option for Renovascular Hypertension. ( 25812711 )
2015
50
Gastric S-nitrosothiol formation drives the antihypertensive effects of oral sodium nitrite and nitrate in a rat model of renovascular hypertension. ( 26159506 )
2015

Variations for Renovascular Hypertension

Expression for Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for Renovascular Hypertension

GO Terms for Renovascular Hypertension

Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ACE ADM CMA1 EDN1 NPPA NPPB
2 extracellular space GO:0005615 9.17 ACE ADM EDN1 HMOX1 NPPA NPPB

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 32)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.91 ADM HMOX1 NF1 NOS3
2 heart development GO:0007507 9.83 ADM EDN1 NF1
3 response to lipopolysaccharide GO:0032496 9.81 ADM EDN1 REN
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.79 ADM AGTR1 EDN1
5 positive regulation of angiogenesis GO:0045766 9.76 ADM CMA1 HMOX1 NOS3
6 kidney development GO:0001822 9.74 ACE AGTR1 REN
7 response to nicotine GO:0035094 9.65 EDN1 HMOX1
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.65 HMOX1 NOS3
9 positive regulation of vasodilation GO:0045909 9.65 ADM HMOX1 NOS3
10 response to hypoxia GO:0001666 9.65 ADM EDN1 HMOX1 NF1 NPPA
11 blood vessel remodeling GO:0001974 9.64 ACE NOS3
12 regulation of angiogenesis GO:0045765 9.64 HMOX1 NF1
13 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.63 AGTR1 EDN1
14 phosphatidylinositol 3-kinase signaling GO:0014065 9.62 EDN1 NF1
15 cGMP biosynthetic process GO:0006182 9.62 NPPA NPPB
16 regulation of vasoconstriction GO:0019229 9.61 ACE AGTR1 EDN1
17 response to muscle stretch GO:0035994 9.6 EDN1 NPPA
18 beta-amyloid metabolic process GO:0050435 9.59 ACE REN
19 positive regulation of urine volume GO:0035810 9.58 EDN1 NPPB
20 positive regulation of renal sodium excretion GO:0035815 9.58 EDN1 NPPB
21 positive regulation of heart rate GO:0010460 9.58 ADM EDN1 NPPA
22 receptor guanylyl cyclase signaling pathway GO:0007168 9.56 NPPA NPPB
23 body fluid secretion GO:0007589 9.55 EDN1 NPPB
24 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.54 EDN1 NOS3
25 regulation of vasodilation GO:0042312 9.54 ACE AGTR1 NPPB
26 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.52 ACE AGTR1
27 renin-angiotensin regulation of aldosterone production GO:0002018 9.51 AGTR1 REN
28 angiotensin maturation GO:0002003 9.5 ACE CMA1 REN
29 smooth muscle hyperplasia GO:0014806 9.49 HMOX1 NOS3
30 regulation of blood vessel diameter GO:0097746 9.33 ACE AGTR1 NPPB
31 regulation of blood vessel size GO:0050880 9.26 EDN1 NOS3 NPPA NPPB
32 regulation of blood pressure GO:0008217 9.17 ACE EDN1 HMOX1 NOS3 NPPA NPPB

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 receptor binding GO:0005102 9.55 ADM EDN1 NPPA NPPB REN
2 endopeptidase activity GO:0004175 9.43 ACE CMA1 REN
3 bradykinin receptor binding GO:0031711 8.96 ACE AGTR1
4 hormone activity GO:0005179 8.92 ADM EDN1 NPPA NPPB

Sources for Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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