MCID: RNV001
MIFTS: 56

Renovascular Hypertension malady

Cardiovascular category

Summaries for Renovascular Hypertension

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renovascular Hypertension, also known as hypertension, renovascular, is related to fibromuscular dysplasia and focal segmental glomerulosclerosis. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The drugs fenoldopam and fenoldopam mesylate and the compounds norepinephrine and captopril have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Renovascular Hypertension

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 40NCIt, 35MeSH, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

renovascular hypertension 8
hypertension, renovascular 61
hypertension renovascular 45


External Ids:

Disease Ontology8 DOID:1591
NCIt40 C85044
MeSH35 D006978
ICD1025 I15.0

Related Diseases for Renovascular Hypertension

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Renovascular Hypertension family:

benign renovascular hypertension malignant renovascular hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 191)
idRelated DiseaseScoreTop Affiliating Genes
1fibromuscular dysplasia30.9REN
2focal segmental glomerulosclerosis30.3PDGFA, EDN1, AGTR1, AGT, REN, ACE
3adenoma30.1S100A6, REN
4portal hypertension30.1EDN1, REN
5hypertension, diastolic30.1REN, ACE
6nephrosclerosis30.1ACE, AGTR1
7low renin hypertension30.1EDN1, REN
8vascular disease30.1SERPINC1, HMOX1, CAT
9insulin resistance30.1EDN1, AGTR1, AGT, ACE
10pediatric hypertension10.6
11malignant renovascular hypertension10.6
12neurofibromatosis10.5
13takayasu's arteritis10.5
14n syndrome10.5
15renal dysplasia10.5
16moyamoya disease10.4
17nephropathy-hypertension10.4
18benign renovascular hypertension10.3
19antiphospholipid syndrome10.3
20aortitis10.3
21focal glomerulosclerosis10.3
22hypertensive retinopathy10.3
23horseshoe kidney10.3
24marfan syndrome10.2
25systemic lupus erythematosus10.2
26abdominal aortic aneurysm10.2
27aortic aneurysm10.2
28subclavian steal syndrome10.1
29carotid stenosis10.1
30goldenhar syndrome10.1
31williams-beuren syndrome10.1
32pulmonary edema10.1
33arteriovenous malformation10.1
34alstrom syndrome10.1
35hydronephrosis10.1
36achalasia10.1
37adrenal neuroblastoma10.1
38polyarteritis nodosa10.1
39angiodysplasia10.1
40alagille syndrome10.1
41erythromelalgia10.1
42melorheostosis10.1
43renal tuberculosis10.1
44paraganglioma10.1
45adrenal adenoma10.1
46tuberculosis10.1
47ehlers-danlos syndrome type iv10.1
48aortic coarctation10.1
49medullary sponge kidney10.1
50ectodermal dysplasia10.1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Clinical Features for Renovascular Hypertension

Drugs & Therapeutics for Renovascular Hypertension

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Renovascular Hypertension

Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Search CenterWatch for Renovascular Hypertension

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Renovascular Hypertension:

33
Bone marrow, Brain, Cortex, Heart, Smooth muscle, Kidney, Liver, Monocytes, T cells, B cells, Endothelial, Fetal brain, Prefrontal cortex, Cardiac myocytes, Fetal liver, Adrenal cortex

Animal Models for Renovascular Hypertension or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Renovascular Hypertension

Sources:
51PubMed
See all sources

Articles related to Renovascular Hypertension:

(show top 50)    (show all 576)
idTitleAuthorsYear
1
Successful percutaneous transluminal angioplasty for the treatment of renovascular hypertension with an atrophic kidney. (24384893)
2014
2
Endovascular treatment of stenoses in a pediatric patient with incomplete aortic duplication, mesenteric ischemia, and renovascular hypertension. (23141677)
2013
3
Reproductive dysfunction in female rats with renovascular hypertension. (23382333)
2013
4
Redox signaling is an early event in the pathogenesis of renovascular hypertension. (24025423)
2013
5
Treatment for renovascular hypertension due to fibromuscular dysplasia of renal arteries with renal autotransplantation. (23511770)
2013
6
Optimal medical management in patients with renovascular hypertension. (23494905)
2013
7
The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats. (22565127)
2012
8
Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension. (21434884)
2011
9
Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension. (21058008)
2011
10
In vivo bioluminescence imaging reveals redox-regulated activator protein-1 activation in paraventricular nucleus of mice with renovascular hypertension. (21173341)
2011
11
Dual endothelin-converting enzyme/neutral endopeptidase inhibition: a novel treatment for renovascular hypertension beyond blood pressure lowering? (21339473)
2011
12
Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension. (20331602)
2010
13
The role of nephrectomy of the atrophic kidney in bearers of renovascular hypertension. (20450500)
2010
14
Quercetin restores plasma nitrite and nitroso species levels in renovascular hypertension. (20694791)
2010
15
Translesional pressure gradients to predict blood pressure response after renal artery stenting in patients with renovascular hypertension. (21078879)
2010
16
Pediatric renovascular hypertension in Thailand: CT angiographic findings. (19685045)
2009
17
The effects of renovascular hypertension on repolarization of ventricular epicardium. (19675821)
2009
18
Antioxidant treatment with tempol and apocynin prevents endothelial dysfunction and development of renovascular hypertension. (19779472)
2009
19
Medullary sponge kidney associated with multivessel fibromuscular dysplasia: report of a case with renovascular hypertension. (18203794)
2008
20
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. (17531161)
2007
21
Renal extraction of circulating adiponectin in patients with renovascular hypertension. (17444282)
2007
22
Flow- and acetylcholine-induced dilatation in small arteries from rats with renovascular hypertension--effect of tempol treatment. (17482591)
2007
23
Renovascular hypertension commencing during fetal life. (16990369)
2007
24
Endogenous angiotensin II enhances atherogenesis in apoprotein E-deficient mice with renovascular hypertension through activation of vascular smooth muscle cells. (17204292)
2007
25
Renal autotransplantation for the treatment of complex renovascular hypertension. (17175289)
2006
26
Vasopeptidase inhibition normalizes blood pressure and restores endothelial function in renovascular hypertension. (17139187)
2006
27
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. (15372104)
2004
28
Renovascular hypertension in mice with brain-selective overexpression of AT1a receptors is buffered by increased nitric oxide production in the periphery. (15284190)
2004
29
A successful management of concomitant renovascular hypertension and symptomatic subclavian steal syndrome due to Takayasu's arteritis using balloon angioplasty and axillo-axillary bypass grafting. (14672533)
2003
30
Incorporating patient-centered outcomes in the analysis of cost-effectiveness: imaging strategies for renovascular hypertension. (14627591)
2003
31
Evaluation of the patients with renovascular hypertension after percutaneous revascularization by Doppler ultrasonography. (12714228)
2003
32
Renovascular hypertension secondary to spontaneous renal artery dissection and treatment with stenting. (12846352)
2003
33
Ac-SDKP reverses cardiac fibrosis in rats with renovascular hypertension. (14581293)
2003
34
Renovascular hypertension, endothelial function, and oxidative stress. (12421899)
2002
35
Renovascular hypertension, endothelial function, and oxidative stress. (12422890)
2002
36
Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. (11375280)
2001
37
Imaging of renovascular hypertension: respective values of renal scintigraphy, renal Doppler US, and MR angiography. (10992024)
2000
38
Renal vascular interaction of angiotensin II and prostaglandins in renovascular hypertension. (10413062)
1999
39
Renovascular hypertension in bradykinin B2-receptor knockout mice. (9740617)
1998
40
Medical and non-medical approaches to renovascular hypertension. (9141238)
1997
41
Steady-state captopril renography: continuous monitoring of the captopril-induced increase in 99mTc-MAG3 mean parenchymal transit time in renovascular hypertension. (9211759)
1997
42
Renography in renovascular hypertension. (8879858)
1996
43
Diagnosis of renovascular hypertension by echo-Doppler velocimetry. (8840548)
1996
44
A case of renovascular hypertension with marked polyuria after percutaneous transluminal renal angioplasty. (8742962)
1996
45
Unique cause of renovascular hypertension: melorheostosis associated with a malformation of the renal arteries. (8642192)
1996
46
Differences between 99mTc-DTPA and 99mTc-MAG3 captopril renographies in renovascular hypertension. (8800457)
1996
47
The diagnosis of renovascular hypertension with technetium-99m-ethylenedicysteine captopril scintigraphy. (8854196)
1996
48
Quantitative analysis of retinal vascular changes in essential and renovascular hypertension. (8903641)
1995
49
Furosemide-131I-hippuran renography after angiotensin-converting enzyme inhibition for the diagnosis of renovascular hypertension. (1986589)
1991
50
Hypertensive retinopathy in renovascular hypertension. (7360169)
1980

Genetic Variations for Renovascular Hypertension

Expression for genes affiliated with Renovascular Hypertension

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for genes affiliated with Renovascular Hypertension

Sources:
30KEGG, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB, 52QIAGEN
See all sources

Compounds for genes affiliated with Renovascular Hypertension

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1norepinephrine45 11 2412.4HMOX1, S100A6
2captopril45 29 50 60 1114.3REN, KNG1, EDN1
3isoproterenol45 1111.3KNG1, AGTR1
4alacepril4510.1NPPA, NPPB, ACE, REN
5aliskiren45 1111.1ACE, AGTR1, AGT, REN
6imidapril4510.0KNG1, NPPA, ACE, NPPB
7benazepril45 1111.0AGT, NPPA, ACE, REN, AGTR1
8saralasin4510.0KNG1, AGTR1, AGT, REN, ACE
9eprosartan45 29 1112.0AGT, REN, AGTR1, KNG1, ACE
10lacidipine4510.0EDN1, REN, ACE, KNG1, AGTR1
11omapatrilat459.9REN, EDN1, NPPA, KNG1, ACE
12fosinopril45 1110.9AGTR1, NPPB, ACE, REN, NPPA
13urodilatin459.9REN, EDN1, NPPB, NPPA
14bisoprolol45 50 1111.9ACE, REN, NPPA, NPPB
15atenolol45 29 50 11 2413.9REN, ACE, AGT, AGTR1, NPPB
16isosorbide dinitrate45 50 1111.9ACE, KNG1, EDN1, NPPA, HMOX1
17hanp459.9EDN1, NPPA, NPPB, REN
18telmisartan45 29 1111.9REN, NPPB, ACE, AGT, AGTR1
19chymostatin459.8AGT, AGTR1, CMA1, EDN1, ACE, REN
20spironolactone50 45 60 29 1113.8NPPA, REN, AGTR1, ACE, NPPB
21cilazapril45 1110.8ACE, AGTR1, KNG1, EDN1, NPPA, REN
22quinapril45 1110.8ACE, NPPA, KNG1, EDN1, AGTR1, REN
23olmesartan45 29 1111.8ACE, REN, AGT, AGTR1
24ramipril45 1110.8NPPB, REN, NPPA, KNG1, AGTR1, ACE
25amlodipine45 50 11 2412.8AGT, NPPB, NPPA, ACE, REN, AGTR1
26valsartan45 60 29 1112.8EDN1, AGTR1, AGT, REN, ACE, NPPB
27candesartan45 29 1111.8AGT, REN, AGTR1, KNG1, NPPB, ACE
28carvedilol45 50 29 1112.7NPPA, REN, AGTR1, NPPB, EDN1, ACE
29phosphoramidon45 1110.7ACE, KNG1, EDN1, NPPA, NPPB
30perindopril45 50 1111.7NPPA, NPPB, KNG1, AGTR1, REN, AGT
31lisinopril45 11 2411.7AGT, REN, AGTR1, KNG1, NPPA, ACE
32enalaprilat459.6KNG1, AGT, REN, ACE, NPPA, EDN1
33diltiazem45 29 1111.6SERPINC1, REN, AGT, AGTR1, EDN1, KNG1
34trandolapril45 1110.6NPPB, EDN1, KNG1, AGTR1, REN, ACE
35nitroglycerin45 1110.6AGTR1, REN, NPPA, ACE, NPPB, EDN1
36phenylephrine45 29 11 2412.6EDN1, NPPA, NPPB, AGT, KNG1, AGTR1
37guanylate459.5KNG1, NPPB, AGT, NPR2, NPPA, AGTR1
388-isoprostane459.5CAT, AGTR1, HMOX1, EDN1, NPPB
39furosemide45 50 60 29 11 2414.5NPPA, NPPB, ACE, AGTR1, REN
40l-nmma459.5CAT, AGT, NPPA, EDN1, KNG1, AGTR1
41s-nitroso-n-acetylpenicillamine459.5NPPA, EDN1, HMOX1, NPPB, CAT
42enalapril45 50 1111.5NPPB, NPPA, EDN1, KNG1, AGTR1, AGT
43ang ii459.4NPPB, NPPA, EDN1, KNG1, REN, ACE
44nifedipine45 50 29 1112.4ACE, EDN1, REN, AGT, AGTR1, KNG1
45digoxin45 50 60 11 2413.3REN, NPPB, ACE, NPPA, AGTR1
46cgmp45 2910.3NPR2, NPPB, KNG1, AGT, REN, HMOX1
47sodium nitroprusside459.2CAT, NPPB, HMOX1, REN, AGTR1, KNG1
48losartan45 50 29 1112.2KNG1, AGTR1, PDGFA, NPPB, NPPA, EDN1
49prostacyclin459.1HMOX1, REN, AGT, AGTR1, KNG1, EDN1
50nitric oxide45 11 2410.8AGT, AGTR1, HMOX1, ACE, KNG1, REN

GO Terms for genes affiliated with Renovascular Hypertension

Sources:
16Gene Ontology
See all sources

Cellular components related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6NPPB, NPPA, EDN1, KNG1, AGT, REN
2extracellular spaceGO:0056158.2SERPINC1, PDGFA, NPPB, NPPA, EDN1, KNG1

Biological processes related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:00201910.5AGT, ACE
2positive regulation of NAD(P)H oxidase activityGO:03386410.4AGTR1, AGT
3regulation of blood vessel size by renin-angiotensinGO:00203410.4AGT, AGTR1
4regulation of renal sodium excretionGO:03581310.4AGT, AGTR1
5regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.4ACE, AGTR1
6renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT, REN
7peptide metabolic processGO:00651810.3CMA1, DNPEP
8positive regulation of cholesterol esterificationGO:01087310.3AGTR1, AGT
9artery smooth muscle contractionGO:01482410.3EDN1, AGT
10cGMP biosynthetic processGO:00618210.3NPPA, NPR2, NPPB
11receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPB, NPR2, NPPA
12regulation of vasodilationGO:04231210.3NPPB, AGTR1, ACE
13regulation of smooth muscle cell migrationGO:01491010.3ACE, PDGFA
14positive regulation of cardiac muscle hypertrophyGO:01061310.2AGT, EDN1
15low-density lipoprotein particle remodelingGO:03437410.2AGT, AGTR1
16angiotensin maturationGO:00200310.2AGT, REN, CMA1, ACE
17body fluid secretionGO:00758910.2EDN1, NPPB
18positive regulation of urine volumeGO:03581010.2KNG1, EDN1, NPPB
19positive regulation of cellular protein metabolic processGO:03227010.2AGTR1, AGT
20kidney developmentGO:00182210.1AGTR1, AGT, REN, ACE
21regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1, EDN1
22positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1CAT, PDGFA, AGT
23elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, EDN1
24negative regulation of blood coagulationGO:03019510.1KNG1, EDN1
25positive regulation of renal sodium excretionGO:03581510.0NPPB, EDN1, KNG1, AGT
26positive regulation of fibroblast proliferationGO:04814610.0S100A6, PDGFA, AGT
27regulation of blood pressureGO:0082179.8ACE, HMOX1, REN, NPPA, NPR2, NPPB
28regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
29elevation of cytosolic calcium ion concentrationGO:0072049.8EDN1, KNG1, AGTR1

Molecular functions related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.0AGTR1, ACE
2acetyltransferase activator activityGO:0106989.8AGTR1, AGT
3hormone activityGO:0051799.7NPPB, NPPA, EDN1, AGT
4receptor bindingGO:0051029.3RCHY1, REN, KNG1, NPPA, NPPB, CAT
5protein homodimerization activityGO:0428038.8HMOX1, CLIP1, RCHY1, PDGFA, S100A6, CAT

Products for genes affiliated with Renovascular Hypertension

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renovascular Hypertension

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet