MCID: RNV001
MIFTS: 62

Renovascular Hypertension malady

Cardiovascular diseases category
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Summaries for Renovascular Hypertension

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Wikipedia:65 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards based summary: Renovascular Hypertension, also known as hypertension, renovascular, is related to fibromuscular dysplasia and hypertension. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and superoxide radicals degradation. The drugs fenoldopam and fenoldopam mesylate and the compounds alacepril and lacidipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Renovascular Hypertension

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
See all sources

Renovascular Hypertension, Aliases & Descriptions:

Name: Renovascular Hypertension 8
Hypertension, Renovascular 62
 
Hypertension Renovascular 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology8 DOID:1591
MeSH34 D006978
NCIt39 C85044
ICD1025 I15.0

Related Diseases for Renovascular Hypertension

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Diseases in the Renovascular Hypertension family:

Malignant Renovascular Hypertension Benign Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1fibromuscular dysplasia31.9REN
2hypertension31.3AGTR1, NPPB, NPPA, ALB, ACE, REN
3congestive heart failure31.1REN
4nephrosclerosis31.0ACE, AGTR1
5hypertension, diastolic30.9REN, ACE
6renal hypertension30.9ACE, REN, EDN1
7focal segmental glomerulosclerosis30.5ACE, ALB, AGTR1
8hypertensive nephropathy30.5ALB, ACE
9nephrotic syndrome30.4SERPINC1, ACE, ALB, NPPA
10vascular disease30.3SERPINC1, LCN2, CAT, HMOX1
11glomerulosclerosis30.3EDN1, REN, ACE, ALB, AGTR1
12glomerulonephritis30.2AGTR1, ALB, CAT, LCN2
13ischemia30.1EDN1, SOD1, LCN2, CAT, HMOX1, NPPB
14proteinuria29.6EDN1, INS, REN, ACE, LCN2, ALB
15insulin resistance29.5EDN1, INS, ACE, LCN2, ALB, AGTR1
16essential hypertension29.1NPPB, NPPA, NPR2, ALB, ACE, REN
17endotheliitis10.7
18hypoaldosteronism10.6REN
19oligohydramnios10.6ACE
20malignant renovascular hypertension10.6
21mitral valve disease10.6NPPA
22neurofibromatosis10.6
23aneurysm10.6
24anuria10.5ACE
25takayasu's arteritis10.5
26dumping syndrome10.5NPPA
27central sleep apnea10.5NPPB
28sick sinus syndrome10.5NPPA
29malignant hypertension10.5REN, ACE
30renal tubular dysgenesis10.4REN, AGTR1
31dysfibrinogenemia10.4SERPINC1
32conn's syndrome10.4REN, NPPA
33aortic disease10.4FBN1
34low renin hypertension10.4EDN1, REN
35moyamoya disease10.4
36diabetic cataract10.4CAT
37syndrome of inappropriate antidiuretic hormone10.4NPPA, NPPB
38mitral valve stenosis10.4NPPA, NPPB
39pure autonomic failure10.4REN, ACE, NPPA
40heart valve disease10.4NPPA, NPPB
41mitral valve prolapse10.4FBN1, AGTR1
42raynaud disease10.4EDN1, AGTR1
43aortitis10.3
44benign renovascular hypertension10.3
45hypertensive retinopathy10.3
46horseshoe kidney10.3
47hypermethioninemia10.3SOD1
48polycystic kidney disease, autosomal dominant10.3FBN1, REN, ACE
49erythropoietic protoporphyria10.3HMOX1, CAT
50renal fibrosis10.3REN, HMOX1, AGTR1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Symptoms for Renovascular Hypertension

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Drugs & Therapeutics for Renovascular Hypertension

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Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Renovascular Hypertension

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Anatomical Context for Renovascular Hypertension

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MalaCards organs/tissues related to Renovascular Hypertension:

32
Kidney, Endothelial, Testes, Heart, Liver, Brain, Smooth muscle, Monocytes, Bone marrow, Bone, Cortex, Prefrontal cortex, Neutrophil

Animal Models for Renovascular Hypertension or affiliated genes

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Publications for Renovascular Hypertension

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Articles related to Renovascular Hypertension:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass. (24946879)
2014
2
Renovascular hypertension: A report of 21 cases. (24434389)
2014
3
Renovascular hypertension: is there still a role for stent revascularization? (23917028)
2013
4
Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-I^ and MMPs, and decreases vascular remodeling in renovascular hypertension. (23806385)
2013
5
The Case: An unusual cause of renovascular hypertension. (19444276)
2009
6
Percutaneous balloon angioplasty of renovascular hypertension in pediatric cases. (19241923)
2008
7
Angiographic and intravascular ultrasound assessment of immediate and 9-month efficacy of percutaneous transluminal renal artery balloon angioplasty with subsequent brachytherapy in patients with renovascular hypertension. (18772602)
2008
8
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. (17531161)
2007
9
Diagnosis and management of renovascular disease and renovascular hypertension. (17485974)
2007
10
A successful therapy of renovascular hypertension. (17051904)
2006
11
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
12
Where do we stand with renovascular hypertension? (15855217)
2005
13
Effects of chronic quercetin treatment in experimental renovascular hypertension. (15792364)
2005
14
Congenital solitary kidney with renovascular hypertension diagnosed by means of captopril-enhanced renography and magnetic resonance angiography. (15876820)
2005
15
Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension. (16087779)
2005
16
Renovascular hypertension in a patient with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome. (16130517)
2005
17
Should renal vein catheterization for selective renin determination be performed in patients with suspected renovascular hypertension?]. (15515466)
2004
18
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. (15372104)
2004
19
Renal artery stenosis and a functioning hilar paraganglioma: a rare cause of renovascular hypertension--a case report. (15306959)
2004
20
Renovascular hypertension: diagnostic and therapeutic challenges. (15055332)
2004
21
Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension. (12591015)
2003
22
Renovascular hypertension, endothelial function, and oxidative stress. (12421899)
2002
23
Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension. (11791033)
2002
24
Diagnostic criteria for renovascular hypertension. (12136534)
2002
25
Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system. (12067101)
2002
26
Increased oxidative stress in experimental renovascular hypertension. (11230332)
2001
27
Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. (11422751)
2001
28
Angiotensin converting-like enzymes from urine of untreated renovascular hypertensive and normal patients: purification and characterization. (10741903)
2000
29
Tuberculous abdominal lymphadenopathy causing reversible renovascular hypertension. (11273151)
2000
30
Evaluation and long-term outcome of pediatric renovascular hypertension. (10975320)
2000
31
Nitric oxide modulates the development and surgical reversal of renovascular hypertension in rats. (10826564)
2000
32
Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. (10406830)
1999
33
Renovascular hypertension and prolonged encephalopathy associated with moyamoya disease. (10206139)
1999
34
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
35
Level of vasopressin in renal venous blood of patients with renovascular hypertension due to unilateral stenosis of renal arteries]. (9333766)
1997
36
A comparison of outcome criteria in the diagnosis of renovascular hypertension. (8989973)
1996
37
Role of captopril renography in the diagnosis of renovascular hypertension. (8768915)
1996
38
Diagnosis of renovascular hypertension: feasibility of captopril-sensitized dynamic MR imaging and comparison with captopril scintigraphy. (8610560)
1996
39
Diagnosis of renovascular hypertension: are i.v. digital subtraction angiography and the excretory urograms really outdated compared to captopril renography? (8966007)
1996
40
Renography in renovascular hypertension. (8879858)
1996
41
Diagnosis of renovascular hypertension by echo-Doppler velocimetry. (8840548)
1996
42
Increased nitric oxide activity in early renovascular hypertension. (8769793)
1996
43
Pediatric renovascular hypertension. (8723806)
1996
44
A case of renovascular hypertension with marked polyuria after percutaneous transluminal renal angioplasty. (8742962)
1996
45
Increased vascular collagen and noncollagenous protein synthesis contributes to sustain chronic phase of two-kidney, one-clip renovascular hypertension. (8709342)
1996
46
Renal effects of antihypertensive agents in parenchymal renal disease and renovascular hypertension. (1382165)
1992
47
Aspirin injection test to predict angioplasty outcome in unilateral renovascular hypertension: preliminary report. (1838974)
1991
48
The role of laboratory testing in the diagnosis of renovascular hypertension. (1914198)
1991
49
Percutaneous transluminal renal angioplasty in renovascular hypertension due to atheroma or fibromuscular dysplasia. (6223227)
1983
50
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. (6767370)
1980

Variations for Renovascular Hypertension

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Expression for genes affiliated with Renovascular Hypertension

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Expression patterns in normal tissues for genes affiliated with Renovascular Hypertension

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Pathways for genes affiliated with Renovascular Hypertension

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Compounds for genes affiliated with Renovascular Hypertension

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Compounds related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 260)
idCompoundScoreTop Affiliating Genes
1alacepril449.9NPPA, ACE, REN, NPPB
2lacidipine449.8ACE, EDN1, REN, AGTR1
3bisoprolol44 50 1111.7REN, ACE, NPPA, NPPB
4omapatrilat449.7NPPA, EDN1, REN, ACE
5cilazapril44 1110.7NPPA, REN, EDN1, ACE, AGTR1
6urodilatin449.6EDN1, REN, NPPA, NPPB
7quinapril44 50 1111.6NPPA, ACE, REN, EDN1, AGTR1
8chymostatin449.6EDN1, AGTR1, CMA1, REN, ACE
9hanp449.6NPPA, NPPB, REN, EDN1
10enalaprilat449.6EDN1, REN, NPPB, ACE, NPPA
11atenolol44 50 28 24 1113.5AGTR1, EDN1, ACE, NPPB, REN
12diltiazem44 28 50 1112.5REN, ACE, AGTR1, SERPINC1, EDN1
13isosorbide dinitrate44 50 1111.4NPPA, HMOX1, ACE, EDN1
14trandolapril44 1110.4NPPB, AGTR1, EDN1, REN, ACE, NPPA
15moxonidine449.4REN, ACE, INS, NPPB, NPPA
16carvedilol44 50 28 1112.4REN, AGTR1, NPPA, ACE, EDN1, NPPB
17irbesartan44 28 50 1112.3ACE, AGTR1, ALB, REN, EDN1
18ang ii449.3AGTR1, NPPA, NPPB, ACE, REN, EDN1
19candesartan44 50 28 1112.3REN, ACE, ALB, NPPB, AGTR1
20digoxin44 61 50 24 1113.3NPPB, NPPA, ACE, REN, AGTR1
21fosinopril44 1110.3AGTR1, NPPB, NPPA, ALB, ACE, REN
22lisinopril44 50 24 1112.3NPPA, AGTR1, REN, ACE, ALB, NPPB
23perindopril44 50 1111.3ALB, NPPB, AGTR1, NPPA, REN, ACE
24spironolactone44 61 28 50 1113.2NPPA, NPPB, ACE, REN, AGTR1, ALB
25amlodipine44 50 24 1112.2AGTR1, NPPB, REN, ACE, ALB, NPPA
26furosemide44 61 28 50 24 1114.2ACE, ALB, NPPA, NPPB, AGTR1, REN
27valsartan44 61 28 1112.2REN, EDN1, NPPB, ACE, ALB, AGTR1
28nitroglycerin44 1110.0AGTR1, NPPB, NPPA, EDN1, ACE, REN
29s-nitroso-n-acetylpenicillamine449.0CAT, SOD1, NPPA, HMOX1, NPPB, EDN1
30l-nmma449.0CAT, SOD1, NPPA, NPPB, EDN1, AGTR1
31telmisartan44 28 1111.0REN, INS, AGTR1, NPPB, ALB, ACE
32enalapril44 50 1111.0AGTR1, NPPB, NPPA, ALB, ACE, REN
33captopril44 61 50 28 1113.0EDN1, REN, AGTR1, NPPB, NPPA, ALB
34losartan44 50 28 1111.9NPPB, ALB, EDN1, REN, ACE, AGTR1
35ramipril44 119.8AGTR1, NPPB, NPPA, ALB, REN, INS
36nifedipine44 28 50 1111.7NPPA, HMOX1, ACE, REN, EDN1, AGTR1
378-isoprostane448.5CAT, HMOX1, NPPB, AGTR1, SOD1, INS
38uric acid44 249.5INS, SOD1, CAT, ALB, NPPB, AGTR1
39prostacyclin448.4AGTR1, NPPB, NPPA, EDN1, SERPINC1, SOD1
40sodium nitroprusside448.4NPR2, CAT, REN, SOD1, EDN1, HMOX1
41cgmp44 289.3AGTR1, EDN1, REN, LCN2, HMOX1, NPR2
42indomethacin44 28 61 1111.3ALB, EDN1, SOD1, NPPB, HMOX1, REN
43norepinephrine44 24 1110.1ACE, HMOX1, NPPA, NPPB, S100A6, AGTR1
44rosiglitazone28 44 50 24 1111.8LCN2, AGTR1, ALB, HMOX1, NPPB, INS
45arginine447.5AGTR1, NF1, NPPB, NPPA, HMOX1, EDN1
46cysteine447.3AGTR1, NPPB, HMOX1, NF1, S100A6, ALB
47nitric oxide44 24 119.3NPPB, NPR2, EDN1, NPPA, HMOX1, CAT
48estrogen446.9NPPB, NPPA, S100A6, AGTR1, LCN2, HMOX1
49creatinine446.9EDN1, INS, SERPINC1, SOD1, REN, ACE
50calcium44 50 24 119.5REN, NPPB, NPR2, CMA1, NF1, EDN1

GO Terms for genes affiliated with Renovascular Hypertension

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Cellular components related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.6CMA1, SOD1, FBN1
2extracellular vesicular exosomeGO:0700627.1SUCNR1, SOD1, ACE, LCN2, ALB, S100A6
3extracellular spaceGO:0056156.2NPPB, EDN1, INS, FBN1, SERPINC1, SOD1
4extracellular regionGO:0055766.2SOD1, SERPINC1, FBN1, INS, EDN1, CMA1

Biological processes related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, REN
2regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3AGTR1, ACE
3angiotensin maturationGO:00200310.2CMA1, REN, ACE
4regulation of blood vessel sizeGO:05088010.1NPPA, NPPB
5body fluid secretionGO:00758910.1NPPB, EDN1
6positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.1EDN1, AGTR1
7cGMP biosynthetic processGO:00618210.1NPR2, NPPA, NPPB
8positive regulation of urine volumeGO:03581010.1NPPB, EDN1
9receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPB, NPPA, NPR2
10regulation of vasodilationGO:04231210.1AGTR1, NPPB, ACE
11regulation of vasoconstrictionGO:01922910.0AGTR1, ACE, EDN1
12positive regulation of renal sodium excretionGO:0358159.9EDN1, NPPB
13positive regulation of cellular protein metabolic processGO:0322709.9INS, AGTR1
14superoxide anion generationGO:0425549.9EDN1, SOD1
15regulation of angiogenesisGO:0457659.8HMOX1, NF1
16phosphatidylinositol 3-kinase signalingGO:0140659.7EDN1, NF1
17kidney developmentGO:0018229.6AGTR1, CAT, ACE, REN, FBN1
18heart developmentGO:0075079.5NF1, FBN1, EDN1
19response to hypoxiaGO:0016669.5EDN1, CAT, NF1, NPPA
20cell surface receptor signaling pathwayGO:0071669.4NPPB, NPR2, EDN1
21regulation of blood pressureGO:0082179.0NPPB, SOD1, REN, ACE, HMOX1, NPR2

Molecular functions related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.1ACE, AGTR1
2antioxidant activityGO:0162099.7ALB, CAT
3insulin-like growth factor receptor bindingGO:0051599.5REN, INS
4receptor bindingGO:0051029.3REN, CAT, NPPA, NPPB
5hormone activityGO:0051799.3NPPB, NPPA, INS, EDN1
6protease bindingGO:0020208.9LCN2, SERPINC1, INS
7protein homodimerization activityGO:0428038.1SOD1, LCN2, CAT, S100A6, HMOX1

Products for genes affiliated with Renovascular Hypertension

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  • Antibodies
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Sources for Renovascular Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet