MCID: RNV001
MIFTS: 58

Renovascular Hypertension malady

Cardiovascular diseases category

Summaries for Renovascular Hypertension

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renovascular Hypertension, also known as hypertension, renovascular, is related to hypertension and renal hypertension. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The drugs fenoldopam and fenoldopam mesylate and the compounds norepinephrine and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Renovascular Hypertension

About this section
Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

renovascular hypertension 8
hypertension, renovascular 60
hypertension renovascular 44


External Ids:

Disease Ontology8 DOID:1591
NCIt39 C85044
MeSH34 D006978
ICD1025 I15.0

Related Diseases for Renovascular Hypertension

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.1AGT, REN, ACE, NPPB, NPPA, EDN1
2renal hypertension31.6ACE, REN, EDN1, KNG1
3essential hypertension30.7NPPA, NPR2, NPPB, EDN1, KNG1, AGTR1
4malignant hypertension30.6REN, ACE
5ischemia30.5AGT, HMOX1, EDN1, KNG1, NPPB, CAT
6nephrotic syndrome30.4ACE, SERPINC1, AGT, NPPA
7proteinuria30.4ACE, REN, HMOX1, AGT, EDN1, KNG1
8lupus erythematosus30.3SERPINC1
9nephrosclerosis30.3ACE, AGTR1
10glomerulonephritis30.3CAT, KNG1, AGTR1
11focal segmental glomerulosclerosis30.3EDN1, ACE, REN, AGT, AGTR1, PDGFA
12congestive heart failure30.1REN
13neuroblastoma30.1KNG1
14adenoma30.1S100A6, REN
15portal hypertension30.1EDN1, REN
16vascular disease30.1CAT, HMOX1, SERPINC1
17malignant renovascular hypertension10.5
18neurofibromatosis10.5
19takayasu's arteritis10.5
20moyamoya disease10.4
21benign renovascular hypertension10.3
22antiphospholipid syndrome10.3
23cerebritis10.3
24aortitis10.3
25focal glomerulosclerosis10.3
26hypertensive retinopathy10.3
27arteriovenous fistula10.2
28marfan syndrome10.2
29systemic lupus erythematosus10.2
30hypertensive encephalopathy10.2
31neuronitis10.2
32abdominal aortic aneurysm10.2
33aortic aneurysm10.2
34subclavian steal syndrome10.1
35carotid stenosis10.1
36goldenhar syndrome10.1
37williams-beuren syndrome10.1
38pulmonary edema10.1
39arteriovenous malformation10.1
40alstrom syndrome10.1
41hydronephrosis10.1
42achalasia10.1
43adrenal neuroblastoma10.1
44polyarteritis nodosa10.1
45angiodysplasia10.1
46alagille syndrome10.1
47erythromelalgia10.1
48melorheostosis10.1
49renal tuberculosis10.1
50paraganglioma10.1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Clinical Features for Renovascular Hypertension

About this section

Drugs & Therapeutics for Renovascular Hypertension

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Renovascular Hypertension

Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Search CenterWatch for Renovascular Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Renovascular Hypertension

About this section

Anatomical Context for Renovascular Hypertension

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Renovascular Hypertension:

32
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes, Smooth muscle, Bone marrow, Cortex, Bone, Prefrontal cortex

Animal Models for Renovascular Hypertension or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Renovascular Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.2SERPINC1, HMOX1, CLIP1, REN, NPR2, PDGFA
2MP:00053698.9PDGFA, NPPB, NPR2, NPPA, AGT, REN
3MP:00053678.8SERPINC1, PDGFA, NPPA, EDN1, AGTR1, AGT
4MP:00053858.4PDGFA, NPPB, NPR2, NPPA, EDN1, AGTR1
5MP:00053768.1EDN1, NPPA, NPR2, PDGFA, CAT, KNG1

Publications for Renovascular Hypertension

About this section
Sources:
50PubMed
See all sources

Articles related to Renovascular Hypertension:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Successful percutaneous transluminal angioplasty for the treatment of renovascular hypertension with an atrophic kidney. (24384893)
2014
2
Renovascular hypertension: is there still a role for stent revascularization? (23917028)
2013
3
Reducing oxidative stress in the rostral ventrolateral medulla in renovascular hypertension by peripheral administration of losartan: how and where? (23747953)
2013
4
The role of AT1 receptor-mediated reproductive function in renovascular hypertension in male rats. (22565127)
2012
5
An uncommon cause of renovascular hypertension. (22503378)
2012
6
Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension. (22262021)
2012
7
Pyrrolidine dithiocarbamate down-regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension. (21434884)
2011
8
Comparative study on antioxidant effects and vascular matrix metalloproteinase-2 downregulation by dihydropyridines in renovascular hypertension. (21058008)
2011
9
Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension. (20331602)
2010
10
Brainstem AT1R and iNOS are involved in sympathoexcitation of renovascular hypertension. (20559292)
2010
11
Pediatric renovascular hypertension in Thailand: CT angiographic findings. (19685045)
2009
12
Open partial nephrectomy for pediatric renovascular hypertension. (19412557)
2009
13
Medullary sponge kidney associated with multivessel fibromuscular dysplasia: report of a case with renovascular hypertension. (18203794)
2008
14
Renovascular hypertension due to bilateral renal artery stenosis treated with stent implantation in a 12-year old girl. (21318972)
2008
15
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. (17531161)
2007
16
Renal extraction of circulating adiponectin in patients with renovascular hypertension. (17444282)
2007
17
Imaging modalities for renal artery stenosis in suspected renovascular hypertension: prospective intraindividual comparison of color Doppler US, CT angiography, GD-enhanced MR angiography, and digital substraction angiography. (17497443)
2007
18
A successful therapy of renovascular hypertension. (17051904)
2006
19
Two cases of hyponatremic-hypertensive syndrome in childhood with renovascular hypertension. (16411091)
2006
20
An unusual reason for renovascular hypertension: entrapment of an accessory renal artery by the diaphragmatic crus. (17057017)
2006
21
Report of a case with surprising etiology of renovascular hypertension. (16370157)
2005
22
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. (15372104)
2004
23
Renal artery stenosis and a functioning hilar paraganglioma: a rare cause of renovascular hypertension--a case report. (15306959)
2004
24
Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition. (15106809)
2004
25
A successful management of concomitant renovascular hypertension and symptomatic subclavian steal syndrome due to Takayasu's arteritis using balloon angioplasty and axillo-axillary bypass grafting. (14672533)
2003
26
Interventional radiology for renovascular hypertension in children. (14767846)
2003
27
Incorporating patient-centered outcomes in the analysis of cost-effectiveness: imaging strategies for renovascular hypertension. (14627591)
2003
28
Renovascular hypertension in childhood]. (14978868)
2003
29
Myocyte loss in early left ventricular hypertrophy of experimental renovascular hypertension. (12684765)
2003
30
Aminopeptidase activity in renovascular hypertension. (12552234)
2003
31
Renovascular hypertension, endothelial function, and oxidative stress. (12422890)
2002
32
Congenital abdominal aortic aneurysm causing renovascular hypertension, cardiomyopathy, and death in a 19-day-old neonate. (11528624)
2001
33
Exacerbation of chronic renovascular hypertension and acute renal failure in heme oxygenase-1-deficient mice. (11375280)
2001
34
A case of renovascular hypertension due to bilateral renal artery microaneurysm who succeeded in baby delivery. (11213034)
2001
35
Tc-99m DTPA acetylsalicylic acid (aspirin) renography in the detection of renovascular hypertension. (10983754)
2000
36
Imaging of renovascular hypertension: respective values of renal scintigraphy, renal Doppler US, and MR angiography. (10992024)
2000
37
Renovascular hypertension does not influence repair of glomerular lesions induced by anti-thymocyte glomerulonephritis. (10972677)
2000
38
Franz Volhard and his students' tortuous road to renovascular hypertension. (10792638)
2000
39
Renal vascular interaction of angiotensin II and prostaglandins in renovascular hypertension. (10413062)
1999
40
Successful percutaneous transluminal angioplasty for treatment of renovascular hypertension in a 15-month-old child. (9667412)
1998
41
Neurofibromatosis and renovascular hypertension presenting in early pregnancy. (9027797)
1997
42
Effect of gender on outcomes following renal artery stent placement for renovascular hypertension. (9408615)
1997
43
Diagnosis of renovascular hypertension by echo-Doppler velocimetry. (8840548)
1996
44
Unique cause of renovascular hypertension: melorheostosis associated with a malformation of the renal arteries. (8642192)
1996
45
Renovascular hypertension caused by traumatic arteriovenous fistula. (8758320)
1996
46
Renovascular arterial hypertension. From physiopathology to therapy]. (8703504)
1996
47
Left ventricular structural and functional characteristics in patients with renovascular hypertension, primary aldosteronism and essential hypertension. (8783775)
1996
48
Quantitative analysis of retinal vascular changes in essential and renovascular hypertension. (8903641)
1995
49
Renovascular hypertension: diagnostic and therapeutic strategy]. (1410886)
1992
50
Suppression of renal vein renin profiles by mannitol prophylaxis: implications in the evaluation of renovascular hypertension. (1962648)
1991

Genetic Variations for Renovascular Hypertension

About this section

Expression for genes affiliated with Renovascular Hypertension

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for genes affiliated with Renovascular Hypertension

About this section
Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
See all sources

Compounds for genes affiliated with Renovascular Hypertension

About this section
Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
See all sources

Compounds related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.4HMOX1, S100A6
2captopril44 28 49 59 1114.3REN, KNG1, EDN1
3isoproterenol44 1111.3KNG1, AGTR1
4alacepril4410.1NPPA, NPPB, ACE, REN
5aliskiren44 1111.1ACE, AGTR1, AGT, REN
6imidapril4410.0KNG1, NPPA, ACE, NPPB
7benazepril44 1111.0AGT, NPPA, ACE, REN, AGTR1
8saralasin4410.0KNG1, AGTR1, AGT, REN, ACE
9eprosartan44 28 1112.0AGT, REN, AGTR1, KNG1, ACE
10lacidipine4410.0EDN1, REN, ACE, KNG1, AGTR1
11omapatrilat449.9REN, EDN1, NPPA, KNG1, ACE
12fosinopril44 1110.9AGTR1, NPPB, ACE, REN, NPPA
13urodilatin449.9REN, EDN1, NPPB, NPPA
14bisoprolol44 49 1111.9ACE, REN, NPPA, NPPB
15atenolol44 28 49 11 2413.9REN, ACE, AGT, AGTR1, NPPB
16isosorbide dinitrate44 49 1111.9ACE, KNG1, EDN1, NPPA, HMOX1
17hanp449.9EDN1, NPPA, NPPB, REN
18telmisartan44 28 1111.9REN, NPPB, ACE, AGT, AGTR1
19chymostatin449.8AGT, AGTR1, CMA1, EDN1, ACE, REN
20spironolactone49 44 59 28 1113.8NPPA, REN, AGTR1, ACE, NPPB
21cilazapril44 1110.8ACE, AGTR1, KNG1, EDN1, NPPA, REN
22quinapril44 1110.8ACE, NPPA, KNG1, EDN1, AGTR1, REN
23olmesartan44 28 1111.8ACE, REN, AGT, AGTR1
24ramipril44 1110.8NPPB, REN, NPPA, KNG1, AGTR1, ACE
25amlodipine44 49 11 2412.8AGT, NPPB, NPPA, ACE, REN, AGTR1
26valsartan44 59 28 1112.8EDN1, AGTR1, AGT, REN, ACE, NPPB
27candesartan44 28 1111.8AGT, REN, AGTR1, KNG1, NPPB, ACE
28carvedilol44 49 28 1112.7NPPA, REN, AGTR1, NPPB, EDN1, ACE
29phosphoramidon44 1110.7ACE, KNG1, EDN1, NPPA, NPPB
30perindopril44 49 1111.7NPPA, NPPB, KNG1, AGTR1, REN, AGT
31lisinopril44 11 2411.7AGT, REN, AGTR1, KNG1, NPPA, ACE
32enalaprilat449.6KNG1, AGT, REN, ACE, NPPA, EDN1
33diltiazem44 28 1111.6SERPINC1, REN, AGT, AGTR1, EDN1, KNG1
34trandolapril44 1110.6NPPB, EDN1, KNG1, AGTR1, REN, ACE
35nitroglycerin44 1110.6AGTR1, REN, NPPA, ACE, NPPB, EDN1
36phenylephrine44 28 11 2412.6EDN1, NPPA, NPPB, AGT, KNG1, AGTR1
37guanylate449.5KNG1, NPPB, AGT, NPR2, NPPA, AGTR1
388-isoprostane449.5CAT, AGTR1, HMOX1, EDN1, NPPB
39furosemide44 49 59 28 11 2414.5NPPA, NPPB, ACE, AGTR1, REN
40l-nmma449.5CAT, AGT, NPPA, EDN1, KNG1, AGTR1
41s-nitroso-n-acetylpenicillamine449.5NPPA, EDN1, HMOX1, NPPB, CAT
42enalapril44 49 1111.5NPPB, NPPA, EDN1, KNG1, AGTR1, AGT
43ang ii449.4NPPB, NPPA, EDN1, KNG1, REN, ACE
44nifedipine44 49 28 1112.4ACE, EDN1, REN, AGT, AGTR1, KNG1
45digoxin44 49 59 11 2413.3REN, NPPB, ACE, NPPA, AGTR1
46cgmp44 2810.3NPR2, NPPB, KNG1, AGT, REN, HMOX1
47sodium nitroprusside449.2CAT, NPPB, HMOX1, REN, AGTR1, KNG1
48losartan44 49 28 1112.2KNG1, AGTR1, PDGFA, NPPB, NPPA, EDN1
49prostacyclin449.1HMOX1, REN, AGT, AGTR1, KNG1, EDN1
50nitric oxide44 11 2410.8AGT, AGTR1, HMOX1, ACE, KNG1, REN

GO Terms for genes affiliated with Renovascular Hypertension

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6PDGFA, ACE, CMA1, REN, AGT, KNG1
2extracellular spaceGO:0056158.2PDGFA, ACE, HMOX1, REN, AGT, KNG1

Biological processes related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:00201910.5ACE, AGT
2positive regulation of NAD(P)H oxidase activityGO:03386410.4AGT, AGTR1
3regulation of blood vessel size by renin-angiotensinGO:00203410.4AGT, AGTR1
4regulation of renal sodium excretionGO:03581310.4AGTR1, AGT
5regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.4AGTR1, ACE
6peptide metabolic processGO:00651810.3DNPEP, CMA1
7renin-angiotensin regulation of aldosterone productionGO:00201810.3REN, AGTR1, AGT
8positive regulation of cholesterol esterificationGO:01087310.3AGT, AGTR1
9cGMP biosynthetic processGO:00618210.3NPR2, NPPA, NPPB
10receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPA, NPR2, NPPB
11regulation of smooth muscle cell migrationGO:01491010.3PDGFA, ACE
12artery smooth muscle contractionGO:01482410.3AGT, EDN1
13regulation of vasodilationGO:04231210.3ACE, AGTR1, NPPB
14positive regulation of cardiac muscle hypertrophyGO:01061310.3EDN1, AGT
15low-density lipoprotein particle remodelingGO:03437410.2AGT, AGTR1
16angiotensin maturationGO:00200310.2AGT, REN, CMA1, ACE
17body fluid secretionGO:00758910.2NPPB, EDN1
18positive regulation of urine volumeGO:03581010.2NPPB, EDN1, KNG1
19positive regulation of cellular protein metabolic processGO:03227010.2AGT, AGTR1
20kidney developmentGO:00182210.1REN, ACE, AGT, AGTR1
21regulation of vasoconstrictionGO:01922910.1AGT, EDN1, AGTR1, ACE
22positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1CAT, PDGFA, AGT
23elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, EDN1
24negative regulation of blood coagulationGO:03019510.1KNG1, EDN1
25positive regulation of renal sodium excretionGO:03581510.0AGT, NPPB, EDN1, KNG1
26positive regulation of fibroblast proliferationGO:04814610.0PDGFA, S100A6, AGT
27regulation of blood pressureGO:0082179.8ACE, HMOX1, REN, NPPA, NPPB, NPR2
28regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
29elevation of cytosolic calcium ion concentrationGO:0072049.8AGTR1, KNG1, EDN1

Molecular functions related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.0AGTR1, ACE
2acetyltransferase activator activityGO:0106989.8AGTR1, AGT
3hormone activityGO:0051799.7NPPB, NPPA, EDN1, AGT
4receptor bindingGO:0051029.3RCHY1, REN, KNG1, NPPA, NPPB, CAT
5protein homodimerization activityGO:0428038.8HMOX1, CLIP1, RCHY1, PDGFA, S100A6, CAT

Products for genes affiliated with Renovascular Hypertension

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renovascular Hypertension

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet