MCID: RNV001
MIFTS: 58

Renovascular Hypertension malady

Cardiovascular diseases category

Summaries for Renovascular Hypertension

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63Wikipedia, 32MalaCards
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Wikipedia:63 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renovascular Hypertension, also known as hypertension, renovascular, is related to hypertension and renal hypertension. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Renin-angiotensin system and MicroRNAs in cardiomyocyte hypertrophy. The drugs fenoldopam and fenoldopam mesylate and the compounds norepinephrine and captopril have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are reproductive system and muscle.

Aliases & Classifications for Renovascular Hypertension

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8Disease Ontology, 44Novoseek, 60UMLS, 39NCIt, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

renovascular hypertension 8
hypertension, renovascular 60
hypertension renovascular 44


External Ids:

Disease Ontology8 DOID:1591
NCIt39 C85044
MeSH34 D006978
ICD1025 I15.0

Related Diseases for Renovascular Hypertension

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17GeneCards, 18GeneDecks
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Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 184)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.1AGT, REN, ACE, NPPB, NPPA, EDN1
2renal hypertension31.6ACE, REN, EDN1, KNG1
3essential hypertension30.7NPPA, NPR2, NPPB, EDN1, KNG1, AGTR1
4malignant hypertension30.6REN, ACE
5ischemia30.5AGT, HMOX1, EDN1, KNG1, NPPB, CAT
6nephrotic syndrome30.4ACE, SERPINC1, AGT, NPPA
7proteinuria30.4ACE, REN, HMOX1, AGT, EDN1, KNG1
8lupus erythematosus30.3SERPINC1
9nephrosclerosis30.3ACE, AGTR1
10glomerulonephritis30.3CAT, KNG1, AGTR1
11focal segmental glomerulosclerosis30.3EDN1, ACE, REN, AGT, AGTR1, PDGFA
12congestive heart failure30.1REN
13neuroblastoma30.1KNG1
14adenoma30.1S100A6, REN
15portal hypertension30.1EDN1, REN
16vascular disease30.1CAT, HMOX1, SERPINC1
17malignant renovascular hypertension10.5
18neurofibromatosis10.5
19takayasu's arteritis10.5
20moyamoya disease10.4
21benign renovascular hypertension10.3
22antiphospholipid syndrome10.3
23cerebritis10.3
24aortitis10.3
25focal glomerulosclerosis10.3
26hypertensive retinopathy10.3
27arteriovenous fistula10.2
28marfan syndrome10.2
29systemic lupus erythematosus10.2
30hypertensive encephalopathy10.2
31neuronitis10.2
32abdominal aortic aneurysm10.2
33aortic aneurysm10.2
34subclavian steal syndrome10.1
35carotid stenosis10.1
36goldenhar syndrome10.1
37williams-beuren syndrome10.1
38pulmonary edema10.1
39arteriovenous malformation10.1
40alstrom syndrome10.1
41hydronephrosis10.1
42achalasia10.1
43adrenal neuroblastoma10.1
44polyarteritis nodosa10.1
45angiodysplasia10.1
46alagille syndrome10.1
47erythromelalgia10.1
48melorheostosis10.1
49renal tuberculosis10.1
50paraganglioma10.1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Clinical Features for Renovascular Hypertension

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Drugs & Therapeutics for Renovascular Hypertension

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Renovascular Hypertension

Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Search CenterWatch for Renovascular Hypertension

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Renovascular Hypertension

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Anatomical Context for Renovascular Hypertension

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32MalaCards
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MalaCards organs/tissues related to Renovascular Hypertension:

32
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes, Smooth muscle, Bone marrow, Cortex, Bone, Prefrontal cortex

Animal Models for Renovascular Hypertension or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Renovascular Hypertension:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053899.2SERPINC1, HMOX1, CLIP1, REN, NPR2, PDGFA
2MP:00053698.9PDGFA, NPPB, NPR2, NPPA, AGT, REN
3MP:00053678.8SERPINC1, PDGFA, NPPA, EDN1, AGTR1, AGT
4MP:00053858.4PDGFA, NPPB, NPR2, NPPA, EDN1, AGTR1
5MP:00053768.1EDN1, NPPA, NPR2, PDGFA, CAT, KNG1

Publications for Renovascular Hypertension

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50PubMed
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Articles related to Renovascular Hypertension:

(show top 50)    (show all 581)
idTitleAuthorsYear
1
Mitochondrial targeted peptides attenuate residual myocardial damage after reversal of experimental renovascular hypertension. (24048008)
2014
2
Aortic stent and renal autotransplantation for the management of renovascular hypertension with Takayasu's arteritis: report of a case. (23512530)
2013
3
Renovascular hypertension--is it fibromuscular dysplasia or Takayasu arteritis. (22453736)
2013
4
Takayasu's arteritis presenting as renovascular hypertension. (23538372)
2013
5
Renovascular hypertension in an 8-year-old girl. (23645701)
2013
6
Bowel ischemia in a baby with unspecified renovascular hypertension: a case report. (22152418)
2011
7
The role of oxidative stress in renovascular hypertension. (20678153)
2011
8
Comments regarding 'surgical treatment and long-term outcome of renovascular hypertension in children and adolescents'. (20610289)
2010
9
Chronic antioxidant treatment improves arterial renovascular hypertension and oxidative stress markers in the kidney in Wistar rats. (20186128)
2010
10
Treatment of renovascular hypertension by renal angioplasty]. (18282458)
2008
11
Renovascular hypertension. 8 years experience of a vascular surgery centre. (17653002)
2007
12
Protective role of a novel erythrocyte-derived depressing factor on blood vessels of renovascular hypertensive rats. (17439406)
2007
13
Treatment of renovascular hypertension by transluminal angioplasty--13 years experience in a single centre. (17934918)
2007
14
Renovascular hypertension update. (17087862)
2006
15
Estimation of the ratio of renal artery stenosis with magnetic resonance angiography using parallel imaging technique in suspected renovascular hypertension. (17003568)
2006
16
Renovascular hypertension. (15889969)
2005
17
Changes in autoantibodies against beta1-adrenoceptor and M2-muscarinic receptor during development of renovascular hypertension in rats. (15592645)
2004
18
Acute aortic dissection induced renovascular hypertension. (14729796)
2004
19
Surgical treatment of patients with renovascular hypertension secondary to aneurysmal lesions of the renal arteries. (12811399)
2003
20
Successful treatment of renovascular hypertension has no effect on insulin sensitivity. (14511355)
2003
21
Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension. (11791033)
2002
22
Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system. (12067101)
2002
23
Increased cardiac sympathetic drive in renovascular hypertension. (12023689)
2002
24
Endothelial function and oxidative stress in renovascular hypertension. (12075056)
2002
25
Renovascular hypertension - simultaneous aortic and renal artery reconstruction. (12172861)
2002
26
Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. (11422751)
2001
27
Renovascular hypertension and focal segmental glomerulosclerosis in the contralateral kidney. (11317195)
2001
28
Pediatric renovascular hypertension. (11420923)
2001
29
The adrenal renal vascular connection plays an essential role in the pathogenesis of renovascular hypertension in the rat. (10768849)
2000
30
Development of ideas on renovascular hypertension. (11022890)
2000
31
Renovascular hypertension: screening and therapeutic options. (10875214)
2000
32
Endothelin system-dependent cardiac remodeling in renovascular hypertension. (10082493)
1999
33
Renovascular hypertension. Clinical and diagnostic clues. (10417842)
1999
34
Increased NAD(P)H oxidase-mediated superoxide production in renovascular hypertension: evidence for an involvement of protein kinase C. (9893134)
1999
35
Percutaneous transluminal coronary angioplasty for renovascular hypertension in a child: a case report. (10533305)
1999
36
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
37
Screening for renovascular hypertension in a population with relatively low prevalence. (9814625)
1998
38
Prevention of renovascular and cardiac pathophysiological changes in hypertension by angiotensin II type 1 receptor antisense gene therapy. (9482944)
1998
39
Level of vasopressin in renal venous blood of patients with renovascular hypertension due to unilateral stenosis of renal arteries]. (9333766)
1997
40
Renovascular hypertension may cause nephrotic range proteinuria and focal glomerulosclerosis in contralateral kidney. (9352155)
1997
41
Renovascular hypertension in blacks. (8834702)
1996
42
Renovascular hypertension resulting from nonspecific aortoarteritis in children: midterm results of percutaneous transluminal renal angioplasty and predictors of restenosis. (8571868)
1996
43
Cost efficacy of the diagnosis and therapy of renovascular hypertension. (8543990)
1996
44
Blood pressure-lowering effect of adding grapefruit juice to nifedipine and terazosin in a patient with severe renovascular hypertension. (8665000)
1996
45
ACE inhibitors in the diagnosis of renovascular hypertension. (1730791)
1992
46
Pharmacologic nephrectomy with chronic angiotensin converting enzyme inhibitor treatment in renovascular hypertension in the rat. (2299253)
1990
47
Clinical significance of cerebral aneurysm in renovascular hypertension due to fibromuscular dysplasia: two cases in siblings. (2719343)
1989
48
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. (6767370)
1980
49
Hypertensive retinopathy in renovascular hypertension. (7360168)
1980
50
Renovascular hypertension as a cause of cerebrovascular accident in childhood: a case report. (578301)
1977

Genetic Variations for Renovascular Hypertension

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Expression for genes affiliated with Renovascular Hypertension

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for genes affiliated with Renovascular Hypertension

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Sources:
29KEGG, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB, 51QIAGEN
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Compounds for genes affiliated with Renovascular Hypertension

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 176)
idCompoundScoreTop Affiliating Genes
1norepinephrine44 11 2412.4HMOX1, S100A6
2captopril44 28 49 59 1114.3REN, KNG1, EDN1
3isoproterenol44 1111.3KNG1, AGTR1
4alacepril4410.1NPPB, NPPA, REN, ACE
5aliskiren44 1111.1AGTR1, AGT, REN, ACE
6imidapril4410.0NPPB, NPPA, KNG1, ACE
7benazepril44 1111.0ACE, AGT, REN, AGTR1, NPPA
8saralasin4410.0KNG1, AGTR1, AGT, REN, ACE
9eprosartan44 28 1112.0AGT, REN, AGTR1, KNG1, ACE
10lacidipine4410.0EDN1, REN, ACE, KNG1, AGTR1
11omapatrilat449.9EDN1, NPPA, KNG1, ACE, REN
12fosinopril44 1110.9ACE, AGTR1, NPPA, NPPB, REN
13bisoprolol44 49 1111.9NPPA, REN, ACE, NPPB
14urodilatin449.9EDN1, NPPA, NPPB, REN
15atenolol44 28 49 11 2413.9AGTR1, AGT, REN, ACE, NPPB
16isosorbide dinitrate44 49 1111.9ACE, HMOX1, NPPA, EDN1, KNG1
17telmisartan44 28 1111.9NPPB, AGTR1, AGT, REN, ACE
18chymostatin449.8AGT, AGTR1, CMA1, EDN1, ACE, REN
19hanp449.8REN, EDN1, NPPA, NPPB
20spironolactone49 44 59 28 1113.8ACE, AGTR1, NPPA, NPPB, REN
21cilazapril44 1110.8ACE, AGTR1, KNG1, EDN1, NPPA, REN
22quinapril44 1110.8ACE, NPPA, KNG1, EDN1, AGTR1, REN
23ramipril44 1110.8NPPB, REN, NPPA, KNG1, AGTR1, ACE
24moxonidine449.8NPPB, NPPA, REN, ACE
25amlodipine44 49 11 2412.8NPPB, NPPA, AGTR1, AGT, ACE, REN
26valsartan44 59 28 1112.8EDN1, AGTR1, AGT, REN, ACE, NPPB
27candesartan44 28 1111.8REN, ACE, AGTR1, KNG1, NPPB, AGT
28carvedilol44 49 28 1112.7AGTR1, EDN1, ACE, NPPB, NPPA, REN
29phosphoramidon44 1110.7KNG1, EDN1, NPPB, NPPA, ACE
30perindopril44 49 1111.7NPPA, NPPB, KNG1, AGTR1, REN, AGT
31lisinopril44 11 2411.7AGT, REN, AGTR1, KNG1, NPPA, ACE
32enalaprilat449.6KNG1, AGT, REN, ACE, NPPB, EDN1
33trandolapril44 1110.6AGTR1, NPPB, EDN1, KNG1, REN, ACE
34diltiazem44 28 1111.6SERPINC1, ACE, REN, AGT, AGTR1, EDN1
35nitroglycerin44 1110.6AGTR1, REN, NPPA, ACE, NPPB, EDN1
36phenylephrine44 28 11 2412.6AGT, EDN1, NPPA, NPPB, KNG1, AGTR1
37guanylate449.5NPR2, AGT, KNG1, HMOX1, AGTR1, NPPA
388-isoprostane449.5HMOX1, CAT, NPPB, EDN1, AGTR1
39digoxin44 49 59 11 2413.5REN, NPPB, NPPA, AGTR1, ACE
40l-nmma449.5CAT, AGT, NPPA, EDN1, KNG1, AGTR1
41s-nitroso-n-acetylpenicillamine449.5EDN1, CAT, NPPB, HMOX1, NPPA
42enalapril44 49 1111.5NPPB, NPPA, EDN1, AGTR1, AGT, REN
43ang ii449.4NPPB, NPPA, EDN1, KNG1, REN, ACE
44nifedipine44 49 28 1112.4ACE, EDN1, REN, AGT, AGTR1, KNG1
45furosemide44 49 59 28 11 2414.3REN, ACE, AGTR1, NPPA, NPPB
46cgmp44 2810.3NPR2, NPPB, KNG1, AGT, REN, HMOX1
47sodium nitroprusside449.2CAT, NPPB, HMOX1, REN, AGTR1, KNG1
48losartan44 49 28 1112.2KNG1, AGTR1, AGT, PDGFA, NPPB, NPPA
49prostacyclin449.1HMOX1, REN, AGT, AGTR1, KNG1, EDN1
50nitric oxide44 11 2410.8ACE, CAT, NPPA, EDN1, NPPB, REN

GO Terms for genes affiliated with Renovascular Hypertension

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16Gene Ontology
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Cellular components related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6NPPB, NPPA, EDN1, KNG1, AGT, REN
2extracellular spaceGO:0056158.2SERPINC1, PDGFA, NPPB, NPPA, EDN1, KNG1

Biological processes related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 29)
idNameGO IDScoreTop Affiliating Genes
1regulation of renal output by angiotensinGO:00201910.5AGT, ACE
2positive regulation of NAD(P)H oxidase activityGO:03386410.4AGTR1, AGT
3regulation of blood vessel size by renin-angiotensinGO:00203410.4AGT, AGTR1
4regulation of renal sodium excretionGO:03581310.4AGT, AGTR1
5regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.4ACE, AGTR1
6renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, AGT, REN
7peptide metabolic processGO:00651810.3CMA1, DNPEP
8positive regulation of cholesterol esterificationGO:01087310.3AGTR1, AGT
9artery smooth muscle contractionGO:01482410.3EDN1, AGT
10cGMP biosynthetic processGO:00618210.3NPPA, NPR2, NPPB
11receptor guanylyl cyclase signaling pathwayGO:00716810.3NPPB, NPR2, NPPA
12regulation of vasodilationGO:04231210.3NPPB, AGTR1, ACE
13regulation of smooth muscle cell migrationGO:01491010.3ACE, PDGFA
14positive regulation of cardiac muscle hypertrophyGO:01061310.2AGT, EDN1
15low-density lipoprotein particle remodelingGO:03437410.2AGT, AGTR1
16angiotensin maturationGO:00200310.2AGT, REN, CMA1, ACE
17body fluid secretionGO:00758910.2EDN1, NPPB
18positive regulation of urine volumeGO:03581010.2KNG1, EDN1, NPPB
19positive regulation of cellular protein metabolic processGO:03227010.2AGTR1, AGT
20kidney developmentGO:00182210.1AGTR1, AGT, REN, ACE
21regulation of vasoconstrictionGO:01922910.1ACE, AGT, AGTR1, EDN1
22positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1CAT, PDGFA, AGT
23elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.1AGTR1, EDN1
24negative regulation of blood coagulationGO:03019510.1KNG1, EDN1
25positive regulation of renal sodium excretionGO:03581510.0NPPB, EDN1, KNG1, AGT
26positive regulation of fibroblast proliferationGO:04814610.0S100A6, PDGFA, AGT
27regulation of blood pressureGO:0082179.8ACE, HMOX1, REN, NPPA, NPR2, NPPB
28regulation of blood vessel sizeGO:0508809.8NPPA, NPPB
29elevation of cytosolic calcium ion concentrationGO:0072049.8EDN1, KNG1, AGTR1

Molecular functions related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.0AGTR1, ACE
2acetyltransferase activator activityGO:0106989.8AGTR1, AGT
3hormone activityGO:0051799.7NPPB, NPPA, EDN1, AGT
4receptor bindingGO:0051029.3RCHY1, REN, KNG1, NPPA, NPPB, CAT
5protein homodimerization activityGO:0428038.8HMOX1, CLIP1, RCHY1, PDGFA, S100A6, CAT

Products for genes affiliated with Renovascular Hypertension

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Sources for Renovascular Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet