MCID: RNV001
MIFTS: 52

Renovascular Hypertension malady

Cardiovascular diseases category

Summaries for Renovascular Hypertension

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Wikipedia:63 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards based summary: Renovascular Hypertension, also known as hypertension, renovascular, is related to fibromuscular dysplasia and congestive heart failure. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and superoxide radicals degradation. The drugs fenoldopam and fenoldopam mesylate and the compounds alacepril and lacidipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Renovascular Hypertension

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT, 25ICD10
See all sources

Renovascular Hypertension, Aliases & Descriptions:

Name: Renovascular Hypertension 9
Hypertension, Renovascular 60
 
Hypertension Renovascular 43


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:1591
NCIt38 C85044
MeSH33 D006978
ICD1025 I15.0

Related Diseases for Renovascular Hypertension

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Diseases in the Renovascular Hypertension family:

Malignant Renovascular Hypertension Benign Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idRelated DiseaseScoreTop Affiliating Genes
1fibromuscular dysplasia31.9REN
2congestive heart failure31.0REN
3nephrosclerosis31.0ACE, AGTR1
4hypertension, diastolic30.8REN, ACE
5renal hypertension30.6ACE, REN, EDN1
6focal segmental glomerulosclerosis30.5ACE, ALB, AGTR1
7hypertensive nephropathy30.5ALB, ACE
8nephrotic syndrome30.4SERPINC1, ACE, ALB, NPPA
9vascular disease30.3SERPINC1, LCN2, CAT, HMOX1
10glomerulosclerosis30.3EDN1, REN, ACE, ALB, AGTR1
11glomerulonephritis30.2AGTR1, ALB, CAT, LCN2
12ischemia30.1EDN1, SOD1, LCN2, CAT, HMOX1, NPPB
13proteinuria29.6EDN1, INS, REN, ACE, LCN2, ALB
14endotheliitis10.7
15malignant renovascular hypertension10.6
16hypoaldosteronism10.6REN
17aneurysm10.6
18oligohydramnios10.6ACE
19neurofibromatosis10.6
20mitral valve disease10.6NPPA
21anuria10.5ACE
22takayasu's arteritis10.5
23dumping syndrome10.5NPPA
24central sleep apnea10.5NPPB
25sick sinus syndrome10.5NPPA
26malignant hypertension10.5REN, ACE
27renal tubular dysgenesis10.4REN, AGTR1
28dysfibrinogenemia10.4SERPINC1
29conn's syndrome10.4REN, NPPA
30moyamoya disease10.4
31benign renovascular hypertension10.4
32aortic disease10.4FBN1
33diabetic cataract10.4CAT
34syndrome of inappropriate antidiuretic hormone10.4NPPA, NPPB
35mitral valve stenosis10.4NPPA, NPPB
36pure autonomic failure10.4REN, ACE, NPPA
37heart valve disease10.4NPPA, NPPB
38orthostatic intolerance10.3FBN1, AGTR1
39aortitis10.3
40hypertensive retinopathy10.3
41cerebritis10.3
42horseshoe kidney10.3
43hypermethioninemia10.3SOD1
44polycystic kidney disease, autosomal dominant10.3FBN1, REN, ACE
45protoporphyria, erythropoietic, autosomal recessive10.3HMOX1, CAT
46renal fibrosis10.3REN, HMOX1, AGTR1
47mitral valve insufficiency10.3FBN1, NPPA, NPPB
48systemic lupus erythematosus10.3
49alstrom syndrome10.3
50williams-beuren syndrome10.3

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Symptoms for Renovascular Hypertension

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Drugs & Therapeutics for Renovascular Hypertension

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Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Renovascular Hypertension

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Anatomical Context for Renovascular Hypertension

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MalaCards organs/tissues related to Renovascular Hypertension:

31
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes, Bone marrow, Bone, Cortex, Smooth muscle, Prefrontal cortex, Neutrophil

Animal Models for Renovascular Hypertension or affiliated genes

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Publications for Renovascular Hypertension

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Articles related to Renovascular Hypertension:

(show top 50)    (show all 593)
idTitleAuthorsYear
1
The Nuclear Factor kappaB Inhibitor Pyrrolidine Dithiocarbamate Prevents Cardiac Remodelling and Matrix Metalloproteinase-2 Up-Regulation in Renovascular Hypertension. (25816715)
2015
2
Combined Aliskiren and L-arginine treatment reverses renovascular hypertension in an animal model. (25740291)
2015
3
Attenuated muscle metaboreflex-induced pressor response during postexercise muscle ischemia in renovascular hypertension. (25632024)
2015
4
Sympathoactivation and rho-kinase-dependent baroreflex function in experimental renovascular hypertension with reduced kidney mass. (24946879)
2014
5
Renovascular hypertension: A report of 21 cases. (24434389)
2014
6
Renovascular hypertension: is there still a role for stent revascularization? (23917028)
2013
7
Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-I^ and MMPs, and decreases vascular remodeling in renovascular hypertension. (23806385)
2013
8
The Case: An unusual cause of renovascular hypertension. (19444276)
2009
9
Percutaneous balloon angioplasty of renovascular hypertension in pediatric cases. (19241923)
2008
10
Angiographic and intravascular ultrasound assessment of immediate and 9-month efficacy of percutaneous transluminal renal artery balloon angioplasty with subsequent brachytherapy in patients with renovascular hypertension. (18772602)
2008
11
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. (17531161)
2007
12
Diagnosis and management of renovascular disease and renovascular hypertension. (17485974)
2007
13
A successful therapy of renovascular hypertension. (17051904)
2006
14
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
15
Where do we stand with renovascular hypertension? (15855217)
2005
16
Effects of chronic quercetin treatment in experimental renovascular hypertension. (15792364)
2005
17
Congenital solitary kidney with renovascular hypertension diagnosed by means of captopril-enhanced renography and magnetic resonance angiography. (15876820)
2005
18
Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension. (16087779)
2005
19
Should renal vein catheterization for selective renin determination be performed in patients with suspected renovascular hypertension?]. (15515466)
2004
20
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. (15372104)
2004
21
Renal artery stenosis and a functioning hilar paraganglioma: a rare cause of renovascular hypertension--a case report. (15306959)
2004
22
Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension. (12591015)
2003
23
Renovascular hypertension, endothelial function, and oxidative stress. (12421899)
2002
24
Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension. (11791033)
2002
25
Diagnostic criteria for renovascular hypertension. (12136534)
2002
26
Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system. (12067101)
2002
27
Increased oxidative stress in experimental renovascular hypertension. (11230332)
2001
28
Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. (11422751)
2001
29
Angiotensin converting-like enzymes from urine of untreated renovascular hypertensive and normal patients: purification and characterization. (10741903)
2000
30
Tuberculous abdominal lymphadenopathy causing reversible renovascular hypertension. (11273151)
2000
31
Evaluation and long-term outcome of pediatric renovascular hypertension. (10975320)
2000
32
Nitric oxide modulates the development and surgical reversal of renovascular hypertension in rats. (10826564)
2000
33
Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. (10406830)
1999
34
Renovascular hypertension and prolonged encephalopathy associated with moyamoya disease. (10206139)
1999
35
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
36
Level of vasopressin in renal venous blood of patients with renovascular hypertension due to unilateral stenosis of renal arteries]. (9333766)
1997
37
A comparison of outcome criteria in the diagnosis of renovascular hypertension. (8989973)
1996
38
Role of captopril renography in the diagnosis of renovascular hypertension. (8768915)
1996
39
Diagnosis of renovascular hypertension: feasibility of captopril-sensitized dynamic MR imaging and comparison with captopril scintigraphy. (8610560)
1996
40
Diagnosis of renovascular hypertension: are i.v. digital subtraction angiography and the excretory urograms really outdated compared to captopril renography? (8966007)
1996
41
Renography in renovascular hypertension. (8879858)
1996
42
Diagnosis of renovascular hypertension by echo-Doppler velocimetry. (8840548)
1996
43
Increased nitric oxide activity in early renovascular hypertension. (8769793)
1996
44
Pediatric renovascular hypertension. (8723806)
1996
45
A case of renovascular hypertension with marked polyuria after percutaneous transluminal renal angioplasty. (8742962)
1996
46
Increased vascular collagen and noncollagenous protein synthesis contributes to sustain chronic phase of two-kidney, one-clip renovascular hypertension. (8709342)
1996
47
Renal effects of antihypertensive agents in parenchymal renal disease and renovascular hypertension. (1382165)
1992
48
Aspirin injection test to predict angioplasty outcome in unilateral renovascular hypertension: preliminary report. (1838974)
1991
49
The role of laboratory testing in the diagnosis of renovascular hypertension. (1914198)
1991
50
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. (6767370)
1980

Variations for Renovascular Hypertension

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Expression for genes affiliated with Renovascular Hypertension

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Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for genes affiliated with Renovascular Hypertension

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Compounds for genes affiliated with Renovascular Hypertension

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Compounds related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show top 50)    (show all 260)
idCompoundScoreTop Affiliating Genes
1alacepril439.9NPPA, NPPB, ACE, REN
2lacidipine439.8EDN1, REN, AGTR1, ACE
3bisoprolol43 49 1211.7NPPA, REN, ACE, NPPB
4omapatrilat439.7NPPA, ACE, REN, EDN1
5cilazapril43 1210.7AGTR1, NPPA, REN, ACE, EDN1
6urodilatin439.6NPPA, EDN1, REN, NPPB
7chymostatin439.6EDN1, CMA1, REN, AGTR1, ACE
8quinapril43 49 1211.6AGTR1, NPPA, ACE, REN, EDN1
9hanp439.6NPPB, NPPA, EDN1, REN
10enalaprilat439.6NPPB, ACE, REN, EDN1, NPPA
11atenolol43 49 28 24 1213.5AGTR1, EDN1, REN, ACE, NPPB
12diltiazem43 28 49 1212.5AGTR1, ACE, REN, SERPINC1, EDN1
13trandolapril43 1210.4NPPB, AGTR1, NPPA, ACE, EDN1, REN
14moxonidine439.4NPPB, NPPA, INS, ACE, REN
15digoxin43 59 49 24 1213.4AGTR1, REN, ACE, NPPA, NPPB
16carvedilol43 49 28 1212.4EDN1, NPPB, REN, ACE, NPPA, AGTR1
17irbesartan43 28 49 1212.3EDN1, ACE, ALB, AGTR1, REN
18ang ii439.3EDN1, NPPA, REN, ACE, AGTR1, NPPB
19candesartan43 49 28 1212.3AGTR1, NPPB, ALB, ACE, REN
20olmesartan43 28 1211.3REN, AGTR1, INS, ACE
21fosinopril43 1210.3ALB, NPPA, NPPB, AGTR1, REN, ACE
22lisinopril43 49 24 1212.3NPPB, NPPA, AGTR1, REN, ACE, ALB
23perindopril43 49 1211.3ALB, REN, ACE, NPPB, AGTR1, NPPA
24amlodipine43 49 24 1212.2ACE, REN, NPPA, NPPB, ALB, AGTR1
25spironolactone43 59 28 49 1213.2ACE, REN, AGTR1, NPPB, NPPA, ALB
26furosemide43 59 28 49 24 1214.2ALB, NPPA, AGTR1, NPPB, REN, ACE
27valsartan43 59 28 1212.2REN, ACE, ALB, EDN1, NPPB, AGTR1
28nitroglycerin43 1210.0ACE, REN, SOD1, EDN1, NPPA, NPPB
29s-nitroso-n-acetylpenicillamine439.0SOD1, EDN1, NPPA, CAT, HMOX1, NPPB
30l-nmma439.0SOD1, CAT, NPPA, EDN1, AGTR1, NPPB
31enalapril43 49 1211.0ALB, NPPA, NPPB, AGTR1, ACE, EDN1
32telmisartan43 28 1211.0INS, ACE, ALB, REN, NPPB, AGTR1
33captopril43 59 49 28 1213.0NPPA, ALB, EDN1, REN, ACE, NPPB
34losartan43 49 28 1211.9ALB, NPPA, NPPB, ACE, REN, AGTR1
35ramipril43 129.8AGTR1, ALB, INS, REN, ACE, NPPB
36nifedipine43 28 49 1211.7HMOX1, ACE, REN, EDN1, NPPA, AGTR1
378-isoprostane438.5AGTR1, NPPB, HMOX1, CAT, SOD1, INS
38uric acid43 249.5AGTR1, ALB, CAT, INS, SOD1, NPPB
39prostacyclin438.5SOD1, SERPINC1, EDN1, REN, ACE, AGTR1
40sodium nitroprusside438.4EDN1, SOD1, REN, AGTR1, NPPB, NPPA
41cgmp43 289.3NPPA, NPPB, EDN1, HMOX1, AGTR1, LCN2
42indomethacin43 28 59 1211.2EDN1, ALB, REN, SOD1, NPPB, CAT
43norepinephrine43 24 1210.1ACE, EDN1, INS, S100A6, HMOX1, NPPA
44rosiglitazone28 43 49 24 1211.8AGTR1, NPPB, HMOX1, INS, LCN2, ALB
45arginine437.5EDN1, INS, FBN1, SERPINC1, SOD1, REN
46cysteine437.3NF1, HMOX1, NPPB, AGTR1, S100A6, ALB
47nitric oxide43 24 129.3EDN1, SOD1, REN, NPR2, HMOX1, AGTR1
48estrogen436.9NPPB, INS, FBN1, SERPINC1, LCN2, S100A6
49creatinine436.9AGTR1, NPPB, NPPA, ALB, LCN2, ACE
50calcium43 49 24 129.5NF1, FBN1, NPPB, S100A6, ALB, LCN2

GO Terms for genes affiliated with Renovascular Hypertension

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Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:00310129.6CMA1, SOD1, FBN1
2extracellular vesicular exosomeGO:00700627.1SUCNR1, SOD1, ACE, LCN2, ALB, S100A6
3extracellular spaceGO:00056156.2NPPB, EDN1, INS, FBN1, SERPINC1, SOD1
4extracellular regionGO:00055766.2SOD1, SERPINC1, FBN1, INS, EDN1, CMA1

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:000201810.3AGTR1, REN
2regulation of systemic arterial blood pressure by renin-angiotensinGO:000308110.3AGTR1, ACE
3angiotensin maturationGO:000200310.2CMA1, REN, ACE
4regulation of blood vessel sizeGO:005088010.1NPPA, NPPB
5body fluid secretionGO:000758910.1NPPB, EDN1
6positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:005148210.1EDN1, AGTR1
7cGMP biosynthetic processGO:000618210.1NPR2, NPPA, NPPB
8positive regulation of urine volumeGO:003581010.1NPPB, EDN1
9receptor guanylyl cyclase signaling pathwayGO:000716810.1NPPB, NPPA, NPR2
10regulation of vasodilationGO:004231210.1AGTR1, NPPB, ACE
11regulation of vasoconstrictionGO:001922910.0AGTR1, ACE, EDN1
12positive regulation of renal sodium excretionGO:00358159.9EDN1, NPPB
13positive regulation of cellular protein metabolic processGO:00322709.9INS, AGTR1
14superoxide anion generationGO:00425549.9EDN1, SOD1
15regulation of angiogenesisGO:00457659.8HMOX1, NF1
16phosphatidylinositol 3-kinase signalingGO:00140659.7EDN1, NF1
17kidney developmentGO:00018229.6AGTR1, CAT, ACE, REN, FBN1
18heart developmentGO:00075079.5NF1, FBN1, EDN1
19response to hypoxiaGO:00016669.5EDN1, CAT, NF1, NPPA
20cell surface receptor signaling pathwayGO:00071669.4NPPB, NPR2, EDN1
21regulation of blood pressureGO:00082179.0NPPB, SOD1, REN, ACE, HMOX1, NPR2

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:003171110.1ACE, AGTR1
2antioxidant activityGO:00162099.7ALB, CAT
3insulin-like growth factor receptor bindingGO:00051599.5REN, INS
4receptor bindingGO:00051029.3REN, CAT, NPPA, NPPB
5hormone activityGO:00051799.3NPPB, NPPA, INS, EDN1
6protease bindingGO:00020208.9LCN2, SERPINC1, INS
7protein homodimerization activityGO:00428038.1SOD1, LCN2, CAT, S100A6, HMOX1

Products for genes affiliated with Renovascular Hypertension

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Sources for Renovascular Hypertension

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet