MCID: RNV001
MIFTS: 46

Renovascular Hypertension

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Renovascular Hypertension

MalaCards integrated aliases for Renovascular Hypertension:

Name: Renovascular Hypertension 12 14
Hypertension, Renovascular 42 69
Hypertension Renovascular 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1591
ICD10 33 I15.0
MeSH 42 D006978
NCIt 47 C85044
SNOMED-CT 64 123799005 194790006
UMLS 69 C0020545

Summaries for Renovascular Hypertension

MalaCards based summary : Renovascular Hypertension, also known as hypertension, renovascular, is related to antiphospholipid syndrome and ectodermal dysplasia. An important gene associated with Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Fluid shear stress and atherosclerosis and AGE-RAGE signaling pathway in diabetic complications. The drugs Antihypertensive Agents and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 72 Renovascular hypertension (or \"renal hypertension\") is a condition in which high blood pressure is... more...

Related Diseases for Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
id Related Disease Score Top Affiliating Genes
1 antiphospholipid syndrome 30.4 EDN1 REN
2 ectodermal dysplasia 29.4 ACE EDN1 NPPA REN
3 malignant renovascular hypertension 12.2
4 benign renovascular hypertension 12.0
5 hypothyroidism due to iodide transport defect 10.7 ACE REN
6 primary hyperoxaluria 10.7 ACE REN
7 mody, type ii 10.7 ACE REN
8 listeriosis 10.7 ACE REN
9 non-congenital cyst of kidney 10.6 ACE REN
10 uterine inflammatory disease 10.6 EDN1 REN
11 repetitive stress injuries 10.6 NPPA REN
12 hepatic infarction 10.6 EDN1 REN
13 voyeurism 10.6 ACE REN
14 synovial chondromatosis 10.5 ACE NPPA
15 progressive black carbon hyperpigmentation of infancy 10.5 EDN1 NOS3
16 blackwater fever 10.5 EDN1 NPPA
17 eustachian tube disease 10.5 EDN1 REN
18 pyriform sinus cancer 10.5 NOS3 NPPA
19 indeterminate leprosy 10.5 EDN1 NOS3
20 suppurative otitis media 10.5 ACE NPPA
21 pulmonary valve insufficiency 10.5 ACE REN
22 islet cell tumor 10.5 ACE NOS3
23 lethal congenital contractural syndrome 2 10.5 EDN1 NOS3
24 microphthalmia, isolated, with coloboma 7 10.4 ACE REN
25 atrial septal defect 7, with or without av conduction defects 10.4 ACE NPPA REN
26 hypodontia of incisors and premolars 10.4 ACE NPPA REN
27 hepatocellular adenoma 10.4 ACE NOS3
28 pyogenic arthritis, pyoderma gangrenosum and acne 10.4 ACE NPPA REN
29 traumatic glaucoma 10.4 EDN1 NOS3
30 vestibular disease 10.4 ACE NF1
31 craniosynostosis 7 10.3 ACE NPPA REN
32 silver-russell syndrome due to 11p15 microduplication 10.3 EDN1 NPPA REN
33 calcinosis 10.3 ACE EDN1 REN
34 epithelial predominant pulmonary blastoma 10.3 ACE NOS3 NPPA
35 urinary bladder posterior wall cancer 10.3 NPPA REN
36 hypertrichosis 10.3 ACE NOS3 REN
37 endotheliitis 10.3
38 survival motor neuron spinal muscular atrophy 10.3 ACE NOS3 REN
39 capillary hemangioma 10.3 EDN1 NOS3 REN
40 cervix uteri carcinoma in situ 10.3 ACE NOS3 REN
41 adult respiratory distress syndrome 10.3 ACE EDN1 NPPA
42 munchausen by proxy 10.2 ACE EDN1 NOS3
43 focal dystonia 10.2 ACE NOS3
44 cystinosis 10.2 ACE REN
45 lymphedema 10.2 EDN1 NPPA REN
46 fibromuscular dysplasia 10.2
47 renal fibrosis 10.2 ACE EDN1 NOS3
48 tracheal lymphoma 10.2 CAT NOS3
49 cystic fibrosis and congenital absence of the vas deferens 10.1 AGTR1 REN
50 aneurysm 10.1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to Renovascular Hypertension

Symptoms & Phenotypes for Renovascular Hypertension

MGI Mouse Phenotypes related to Renovascular Hypertension:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 HMOX1 NF1 NOS3 NPPA REN ACE
2 homeostasis/metabolism MP:0005376 10.07 ACE ADM AGTR1 CAT EDN1 HMOX1
3 behavior/neurological MP:0005386 10.02 ACE ADM AGTR1 HMOX1 NF1 NOS3
4 hematopoietic system MP:0005397 10.01 REN ACE ADM AGTR1 HMOX1 NF1
5 endocrine/exocrine gland MP:0005379 9.91 ACE ADM EDN1 HMOX1 NF1 NOS3
6 immune system MP:0005387 9.87 ACE ADM AGTR1 HMOX1 NF1 NOS3
7 mortality/aging MP:0010768 9.81 ACE ADM AGTR1 CAT EDN1 HMOX1
8 liver/biliary system MP:0005370 9.65 ACE ADM HMOX1 NF1 NOS3
9 muscle MP:0005369 9.5 ADM EDN1 HMOX1 NF1 NOS3 NPPA
10 renal/urinary system MP:0005367 9.28 ACE ADM AGTR1 EDN1 HMOX1 NF1

Drugs & Therapeutics for Renovascular Hypertension

Drugs for Renovascular Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antihypertensive Agents Phase 4,Phase 3
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Phase 3
3
Amlodipine Approved Phase 3 88150-42-9 2162
4
Celecoxib Approved, Investigational Phase 3 169590-42-5 2662
5
Candesartan Approved Phase 3 139481-59-7 2541
6
Angiotensin II Investigational Phase 3 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
7 Analgesics Phase 3
8 Analgesics, Non-Narcotic Phase 3
9 Anti-Inflammatory Agents Phase 3
10 Anti-Inflammatory Agents, Non-Steroidal Phase 3
11 Antirheumatic Agents Phase 3
12 calcium channel blockers Phase 3
13 Calcium, Dietary Phase 3
14 Cyclooxygenase 2 Inhibitors Phase 3
15 Cyclooxygenase Inhibitors Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Vasodilator Agents Phase 3
18 Amlodipine, atorvastatin drug combination Phase 3
19 Angiotensin II Type 1 Receptor Blockers Phase 3
20 Angiotensin Receptor Antagonists Phase 3
21 Angiotensinogen Phase 3
22 Anticholesteremic Agents Phase 3
23 Antimetabolites Phase 3
24 Atorvastatin Calcium Phase 3 134523-03-8
25
Candesartan cilexetil Phase 3 145040-37-5 2540
26 Hypolipidemic Agents Phase 3
27 Lipid Regulating Agents Phase 3
28
Amiloride Approved 2016-88-8, 2609-46-3 16231
29
Spironolactone Approved 1952-01-7, 52-01-7 5833
30 diuretics
31 Diuretics, Potassium Sparing
32 Epithelial Sodium Channel Blockers
33 Hormone Antagonists
34 Hormones
35 Hormones, Hormone Substitutes, and Hormone Antagonists
36 Mineralocorticoid Receptor Antagonists
37 Mineralocorticoids
38 Natriuretic Agents
39 Sodium Channel Blockers
40 Angiotensin-Converting Enzyme Inhibitors

Interventional clinical trials:

(show all 16)

id Name Status NCT ID Phase Drugs
1 Revascularization of Renal Artery Stenosis Versus Medical Therapy for the Treatment of Ischemic Nephropathy Unknown status NCT01023373 Phase 4 Medical treatment
2 Renal Stenting With Distal Atheroembolic Protection Unknown status NCT00868972 Phase 2, Phase 3
3 Evaluation of Celecoxib Effects on Amlodipine in Subjects With Existing Hypertension Requiring Antihypertensives Completed NCT02979197 Phase 3 Over-encapsulated 10 mg amlodipine besylate tablet + over-encapsulated 200 mg celecoxib capsule;Over-encapsulated 10 mg amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule;Matched placebo tablet for over-encapsulated amlodipine besylate tablet + matched placebo capsule for over-encapsulated celecoxib capsule
4 Benefits of Medical Therapy Plus Stenting for Renal Atherosclerotic Lesions Completed NCT00081731 Phase 3 Atacand/HCT, Caduet
5 MSC for Occlusive Disease of the Kidney Completed NCT01840540 Phase 1 Arterial infusion of autologous mesenchymal stem cells
6 MRI to Detect Embolism Following Angiography and Angioplasty-Stenting of the Renal Artery Completed NCT00027469 Phase 1
7 Hypoxia and Inflammatory Injury in Human Renovascular Hypertension Recruiting NCT02266394 Phase 1 Mesenchymal stem cell
8 Magnetic Resonance Imaging for Evaluating Kidney Function Completed NCT00006173
9 Cross-sectional Study of Patients With Renal or Craniocervical Fibromuscular Dysplasia Completed NCT02884141
10 REFORM Clinical Study: Treatment of Renal Artery Stenosis With the Formula Balloon-Expandable Stent Completed NCT00631540
11 Renal Atherosclerotic Revascularization Evaluation: RAVE Study Completed NCT00127738
12 The Effects of Amiloride and Spironolactone on Renophysiological and Cardiovascular Variables Completed NCT01195805 Spironolactone;Amiloride
13 Telehealth & Remote Measurement Technologies to Improve Medication Adherence in Hypertension Completed NCT01439256
14 A Prospective Danish National Registry of PTRA in Patients With Renovascular Hypertension Recruiting NCT02770066
15 Renal Stent Placement for the Treatment of Renal Artery Stenosis in Patients With Resistant Hypertension Recruiting NCT01673373
16 Endovascular Therapy for Renal Artery Stenosis in China Not yet recruiting NCT03080519

Search NIH Clinical Center for Renovascular Hypertension

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypertension, renovascular

Genetic Tests for Renovascular Hypertension

Anatomical Context for Renovascular Hypertension

MalaCards organs/tissues related to Renovascular Hypertension:

39
Kidney, Endothelial, Testes, Heart, Liver, Brain, Monocytes

Publications for Renovascular Hypertension

Articles related to Renovascular Hypertension:

(show top 50) (show all 669)
id Title Authors Year
1
Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension. ( 28315847 )
2017
2
New Insights Into Pathophysiology, Diagnosis, and Treatment of Renovascular Hypertension. ( 28270639 )
2017
3
Complex glomerular pathology of thrombotic microangiopathy and focal segmental glomerulosclerosis forms tumor-like mass in a renal transplant donor with severe renovascular hypertension. ( 28509120 )
2017
4
Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28429121 )
2017
5
Sonographic evaluation of renovascular hypertension in the pediatric population: State-of-the-art. ( 28370243 )
2017
6
Successful long-term effects of direct renin inhibitor aliskiren in a patient with atherosclerotic renovascular hypertension. ( 28509129 )
2017
7
Lotus Root Sign in the Renal Artery in Renovascular Hypertension. ( 28250287 )
2017
8
Effects of Baicalin on Blood Pressure and Left Ventricular Remodeling in Rats with Renovascular Hypertension. ( 28622281 )
2017
9
Antihypertensive Effects of Hydroalcoholic Extract of Crataegus Azarolus Subspecies Aronia Fruit in Rats with Renovascular Hypertension: An Experimental Mechanistic Study. ( 28533575 )
2017
10
The differential effects of low and high doses of apelin through opioid receptors on the blood pressure of rats with renovascular hypertension. ( 28275232 )
2017
11
Treatment of severe hypertension in a 14-year-old child: Successful blood pressure control with additive administration of captopril, an angiotensin-converting enzyme inhibitor, in a patient with bilateral renovascular hypertension. ( 28621587 )
2017
12
Oleuropein improves glucose tolerance and lipid profile in rats with simultaneous renovascular hypertension and type 2 diabetes. ( 28347166 )
2017
13
Opioid receptors mediate inotropic and depressor effects of apelin in rats with 2K1C-induced chronic renovascular hypertension. ( 28945940 )
2017
14
Long-Term Outcomes of Pediatric Renovascular Hypertension. ( 28950261 )
2017
15
Selective embolization therapy for intrarenal artery stenosis causing renovascular hypertension: Efficacy and follow-up renal imaging. ( 28560752 )
2017
16
Transplantation of bone marrow-derived MSCs improves renal function and Na(+)+K(+)-ATPase activity in rats with renovascular hypertension. ( 28374150 )
2017
17
Iron restriction in renovascular hypertension. ( 28250410 )
2017
18
Revisiting angioplasty for renovascular hypertension. ( 28852488 )
2017
19
Renovascular hypertension: results in adulthood of renal autotransplantation performed in children-response to comments by Della Schiava and Lermusiaux. ( 28695308 )
2017
20
Comments on Chavent et al.: Renovascular hypertension: results in adulthood of renal autotransplantation performed in children. ( 28695307 )
2017
21
Carotid sinus denervation ameliorates renovascular hypertension in adult Wistar rats. ( 27510951 )
2016
22
Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension. ( 27078869 )
2016
23
Homocysteine and hydrogen sulfide in epigenetic, metabolic and microbiota related renovascular hypertension. ( 27602985 )
2016
24
Exercise training attenuates renovascular hypertension partly via RAS- ROS- glutamate pathway in the hypothalamic paraventricular nucleus. ( 27881877 )
2016
25
Aliskiren and l-arginine treatments restore depressed baroreflex sensitivity and decrease oxidative stress in renovascular hypertension rats. ( 27383506 )
2016
26
Estrogen receptor agonists alleviate cardiac and renal oxidative injury in rats with renovascular hypertension. ( 27399230 )
2016
27
OS 11-03 Role of renal nervous activity in the development of renovascular hypertension in rats. ( 27643367 )
2016
28
Restoration of Mitochondrial Cardiolipin Attenuates Cardiac Damage in Swine Renovascular Hypertension. ( 27247333 )
2016
29
Aortic Intimal Sarcoma Contributes to Atherosclerotic Renovascular Hypertension: An Autopsy Case Report and Review of the Literature. ( 27041160 )
2016
30
Blockade of CCR2 reduces macrophage influx and development of chronic renal damage in murine renovascular hypertension. ( 26661648 )
2016
31
Hypercholesterolemia Impairs Nonstenotic Kidney Outcomes After Reversal of Experimental Renovascular Hypertension. ( 26739189 )
2016
32
Decreased immunoreactivity of visfatin in the pancreas and liver of rats with renovascular hypertension. ( 28078856 )
2016
33
Resveratrol improves vasoprotective effects of captopril on aortic remodeling and fibrosis triggered by renovascular hypertension. ( 26764145 )
2016
34
Imperatorin derivative OW1 inhibits the upregulation of TGF-I^ and MMP-2 in renovascular hypertension-induced cardiac remodeling. ( 27168797 )
2016
35
BehAset's Disease Presenting as Renovascular Hypertension Treated Successfully With Percutaneous Angioplasty. ( 27916225 )
2016
36
OS 11-03 Role of renal nervous activity in the development of renovascular hypertension in rats. ( 27753970 )
2016
37
Infantile Renovascular Hypertension with Failure to Thrive. ( 26965798 )
2016
38
Non-invasive imaging cannot replace formal angiography in the diagnosis of renovascular hypertension. ( 27747454 )
2016
39
Antagonism of endothelin (ETA and ETB) receptors during renovascular hypertension-induced vascular dementia improves cognition. ( 27189349 )
2016
40
Regular exercise alleviates renovascular hypertension-induced cardiac/endothelial dysfunction and oxidative injury in rats. ( 27010894 )
2016
41
Large retroperitoneal immature teratoma leading to renovascular hypertension. ( 28008730 )
2016
42
Selective stent placement versus balloon angioplasty for renovascular hypertension caused by Takayasu arteritis: Two-year results. ( 26730842 )
2016
43
Management of Renovascular Hypertension. ( 27641455 )
2016
44
Novel insights into renovascular hypertension and cardio-renal protection by iron restriction. ( 27604341 )
2016
45
Outcomes of percutaneous transluminal angioplasty for pediatric renovascular hypertension. ( 27634559 )
2016
46
Takayasu arteritis associated with severe renovascular hypertension. ( 26997400 )
2016
47
Therapeutic evaluation of rutin in two-kidney one-clip model of renovascular hypertension in rat. ( 26920631 )
2016
48
Renovascular hypertension: Effects of mesenchymal stem cells in the contralateral hypertensive kidney in rats. ( 27649588 )
2016
49
Prior renovascular hypertension does not predispose to atherosclerosis in mice. ( 27100924 )
2016
50
Percutaneous Transluminal Angioplasty Improved Posterior Reversible Encephalopathy Syndrome due to Renovascular Hypertension. ( 26646732 )
2016

Variations for Renovascular Hypertension

Expression for Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for Renovascular Hypertension

GO Terms for Renovascular Hypertension

Cellular components related to Renovascular Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 ACE ADM CAT EDN1 NPPA REN
2 extracellular space GO:0005615 9.17 ACE ADM CAT EDN1 HMOX1 NPPA

Biological processes related to Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.88 ADM HMOX1 NF1 NOS3
2 heart development GO:0007507 9.8 ADM EDN1 NF1
3 response to lipopolysaccharide GO:0032496 9.77 ADM EDN1 REN
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.76 ADM AGTR1 EDN1
5 positive regulation of angiogenesis GO:0045766 9.71 ADM HMOX1 NOS3
6 response to insulin GO:0032868 9.69 ADM CAT NPPA
7 response to activity GO:0014823 9.64 CAT EDN1
8 cellular response to heat GO:0034605 9.64 HMOX1 NF1
9 response to nicotine GO:0035094 9.63 EDN1 HMOX1
10 regulation of angiogenesis GO:0045765 9.62 HMOX1 NF1
11 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.62 HMOX1 NOS3
12 kidney development GO:0001822 9.62 ACE AGTR1 CAT REN
13 blood vessel remodeling GO:0001974 9.61 ACE NOS3
14 phosphatidylinositol 3-kinase signaling GO:0014065 9.61 EDN1 NF1
15 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 9.59 AGTR1 EDN1
16 response to muscle stretch GO:0035994 9.57 EDN1 NPPA
17 beta-amyloid metabolic process GO:0050435 9.56 ACE REN
18 regulation of blood vessel diameter GO:0097746 9.55 ACE AGTR1
19 regulation of vasoconstriction GO:0019229 9.54 ACE AGTR1 EDN1
20 angiotensin maturation GO:0002003 9.52 ACE REN
21 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.49 ACE AGTR1
22 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.48 EDN1 NOS3
23 response to ozone GO:0010193 9.46 CAT EDN1
24 renin-angiotensin regulation of aldosterone production GO:0002018 9.43 AGTR1 REN
25 positive regulation of heart rate GO:0010460 9.43 ADM EDN1 NPPA
26 response to hypoxia GO:0001666 9.43 ADM CAT EDN1 HMOX1 NF1 NPPA
27 smooth muscle hyperplasia GO:0014806 9.4 HMOX1 NOS3
28 regulation of blood vessel size GO:0050880 9.33 EDN1 NOS3 NPPA
29 regulation of blood pressure GO:0008217 9.1 ACE EDN1 HMOX1 NOS3 NPPA REN

Molecular functions related to Renovascular Hypertension according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.43 CAT HMOX1 NOS3
2 receptor binding GO:0005102 9.35 ADM CAT EDN1 NPPA REN
3 hormone activity GO:0005179 9.33 ADM EDN1 NPPA
4 NADP binding GO:0050661 9.32 CAT NOS3
5 bradykinin receptor binding GO:0031711 8.62 ACE AGTR1

Sources for Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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