MCID: RNV001
MIFTS: 61

Renovascular Hypertension malady

Cardiovascular diseases category

Summaries for Renovascular Hypertension

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66Wikipedia, 34MalaCards
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Wikipedia:66 Renovascular hypertension (or \"renal hypertension\") is a syndrome which consists of high blood... more...

MalaCards: Renovascular Hypertension, also known as hypertension, renovascular, is related to hypertension and fibromuscular dysplasia. An important gene associated with Renovascular Hypertension is REN (renin), and among its related pathways are Cardiomyocyte Differentiation through BMP Receptors and superoxide radicals degradation. The drugs fenoldopam and fenoldopam mesylate and the compounds alacepril and lacidipine have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and testes, and related mouse phenotypes are skeleton and liver/biliary system.

Aliases & Classifications for Renovascular Hypertension

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

renovascular hypertension 9
hypertension, renovascular 63
hypertension renovascular 46


External Ids:

Disease Ontology9 DOID:1591
NCIt41 C85044
MeSH36 D006978
ICD1026 I15.0

Related Diseases for Renovascular Hypertension

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18GeneCards, 19GeneDecks
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Diseases in the Renovascular Hypertension family:

Malignant Renovascular Hypertension Benign Renovascular Hypertension

Diseases related to Renovascular Hypertension via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension32.0AGTR1, NPPB, NPPA, ALB, ACE, REN
2fibromuscular dysplasia31.2REN
3nephrosclerosis30.5ACE, AGTR1
4renal hypertension30.5ACE, EDN1, REN
5nephrotic syndrome30.5NPPA, SERPINC1, ACE, ALB
6ischemia30.5LCN2, HMOX1, SOD1, EDN1, NPPB, CAT
7glomerulosclerosis30.4ALB, REN, EDN1, AGTR1, ACE
8focal segmental glomerulosclerosis30.4ACE, ALB, AGTR1
9congestive heart failure30.4REN
10glomerulonephritis30.3ALB, LCN2, CAT, AGTR1
11hypertension, diastolic30.3ACE, REN
12proteinuria30.3ACE, REN, LCN2, ALB, HMOX1, AGTR1
13essential hypertension30.2AGTR1, INS, EDN1, SOD1, REN, NPPB
14hypertensive nephropathy30.2ALB, ACE
15vascular disease30.2LCN2, HMOX1, CAT, SERPINC1
16insulin resistance30.0AGTR1, EDN1, ALB, LCN2, ACE, INS
17endotheliitis10.6
18malignant renovascular hypertension10.6
19aneurysm10.6
20neurofibromatosis10.5
21takayasu's arteritis10.5
22moyamoya disease10.4
23aortitis10.3
24hypertensive retinopathy10.3
25cerebritis10.3
26benign renovascular hypertension10.3
27horseshoe kidney10.3
28arteriovenous fistula10.2
29neuronitis10.2
30abdominal aortic aneurysm10.2
31systemic lupus erythematosus10.2
32marfan syndrome10.2
33aortic aneurysm10.2
34lupus erythematosus10.2
35hypoaldosteronism10.1REN
36oligohydramnios10.1ACE
37mitral valve disease10.1NPPA
38anuria10.1ACE
39dumping syndrome10.1NPPA
40central sleep apnea10.1NPPB
41sick sinus syndrome10.1NPPA
42malignant hypertension10.1REN, ACE
43renal tubular dysgenesis10.1REN, AGTR1
44dysfibrinogenemia10.1SERPINC1
45conn's syndrome10.1NPPA, REN
46aortic disease10.1FBN1
47low renin hypertension10.1REN, EDN1
48williams-beuren syndrome10.1
49antiphospholipid syndrome10.1
50goldenhar syndrome10.1

Graphical network of the top 20 diseases related to Renovascular Hypertension:



Diseases related to renovascular hypertension

Symptoms for Renovascular Hypertension

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Drugs & Therapeutics for Renovascular Hypertension

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Renovascular Hypertension

Drug clinical trials:

Search ClinicalTrials for Renovascular Hypertension

Search NIH Clinical Center for Renovascular Hypertension

Search CenterWatch for Renovascular Hypertension

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Renovascular Hypertension

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Anatomical Context for Renovascular Hypertension

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34MalaCards
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MalaCards organs/tissues related to Renovascular Hypertension:

34
Kidney, Endothelial, Testes, Heart, Liver, Brain, Smooth muscle, Monocytes, Bone marrow, Bone, Cortex, Prefrontal cortex

Animal Models for Renovascular Hypertension or affiliated genes

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38MGI
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Publications for Renovascular Hypertension

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53PubMed
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Articles related to Renovascular Hypertension:

(show top 50)    (show all 555)
idTitleAuthorsYear
1
Renovascular hypertension: A report of 21 cases. (24434389)
2014
2
Renovascular hypertension: is there still a role for stent revascularization? (23917028)
2013
3
Nebivolol attenuates prooxidant and profibrotic mechanisms involving TGF-I^ and MMPs, and decreases vascular remodeling in renovascular hypertension. (23806385)
2013
4
Endovascular treatment of stenoses in a pediatric patient with incomplete aortic duplication, mesenteric ischemia, and renovascular hypertension. (23141677)
2013
5
The Case: An unusual cause of renovascular hypertension. (19444276)
2009
6
Percutaneous balloon angioplasty of renovascular hypertension in pediatric cases. (19241923)
2008
7
Angiographic and intravascular ultrasound assessment of immediate and 9-month efficacy of percutaneous transluminal renal artery balloon angioplasty with subsequent brachytherapy in patients with renovascular hypertension. (18772602)
2008
8
Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis. (17531161)
2007
9
Diagnosis and management of renovascular disease and renovascular hypertension. (17485974)
2007
10
A successful therapy of renovascular hypertension. (17051904)
2006
11
Diagnostic and treatment of renovascular hypertension in the patient with horseshoe kidney]. (15909888)
2005
12
Where do we stand with renovascular hypertension? (15855217)
2005
13
Effects of chronic quercetin treatment in experimental renovascular hypertension. (15792364)
2005
14
Congenital solitary kidney with renovascular hypertension diagnosed by means of captopril-enhanced renography and magnetic resonance angiography. (15876820)
2005
15
Evaluation of vascular function in apolipoprotein E knockout mice with angiotensin-dependent renovascular hypertension. (16087779)
2005
16
Renovascular hypertension in a patient with systemic lupus erythematosus and secondary antiphospholipid antibody syndrome. (16130517)
2005
17
Should renal vein catheterization for selective renin determination be performed in patients with suspected renovascular hypertension?]. (15515466)
2004
18
Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. (15372104)
2004
19
Renal artery stenosis and a functioning hilar paraganglioma: a rare cause of renovascular hypertension--a case report. (15306959)
2004
20
Renovascular hypertension: diagnostic and therapeutic challenges. (15055332)
2004
21
Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension. (12591015)
2003
22
Renovascular hypertension, endothelial function, and oxidative stress. (12421899)
2002
23
Reduced spontaneous baroreceptor sensitivity in patients with renovascular hypertension. (11791033)
2002
24
Diagnostic criteria for renovascular hypertension. (12136534)
2002
25
Anti-hypertensive effect of water extract of danshen on renovascular hypertension through inhibition of the renin angiotensin system. (12067101)
2002
26
Increased oxidative stress in experimental renovascular hypertension. (11230332)
2001
27
Connexins 40 and 43 are differentially regulated within the kidneys of rats with renovascular hypertension. (11422751)
2001
28
Angiotensin converting-like enzymes from urine of untreated renovascular hypertensive and normal patients: purification and characterization. (10741903)
2000
29
Tuberculous abdominal lymphadenopathy causing reversible renovascular hypertension. (11273151)
2000
30
Evaluation and long-term outcome of pediatric renovascular hypertension. (10975320)
2000
31
Nitric oxide modulates the development and surgical reversal of renovascular hypertension in rats. (10826564)
2000
32
Cyclooxygenase-2 inhibition decreases renin content and lowers blood pressure in a model of renovascular hypertension. (10406830)
1999
33
Renovascular hypertension and prolonged encephalopathy associated with moyamoya disease. (10206139)
1999
34
Mesangial hyperplasia in a patient with renovascular hypertension and proteinuria. (9794597)
1998
35
Treatment of renovascular disease and of renovascular hypertension. (10048497)
1998
36
Level of vasopressin in renal venous blood of patients with renovascular hypertension due to unilateral stenosis of renal arteries]. (9333766)
1997
37
A comparison of outcome criteria in the diagnosis of renovascular hypertension. (8989973)
1996
38
Role of captopril renography in the diagnosis of renovascular hypertension. (8768915)
1996
39
Diagnosis of renovascular hypertension: feasibility of captopril-sensitized dynamic MR imaging and comparison with captopril scintigraphy. (8610560)
1996
40
Diagnosis of renovascular hypertension: are i.v. digital subtraction angiography and the excretory urograms really outdated compared to captopril renography? (8966007)
1996
41
Renography in renovascular hypertension. (8879858)
1996
42
Diagnosis of renovascular hypertension by echo-Doppler velocimetry. (8840548)
1996
43
Increased nitric oxide activity in early renovascular hypertension. (8769793)
1996
44
Pediatric renovascular hypertension. (8723806)
1996
45
A case of renovascular hypertension with marked polyuria after percutaneous transluminal renal angioplasty. (8742962)
1996
46
Increased vascular collagen and noncollagenous protein synthesis contributes to sustain chronic phase of two-kidney, one-clip renovascular hypertension. (8709342)
1996
47
Renal effects of antihypertensive agents in parenchymal renal disease and renovascular hypertension. (1382165)
1992
48
Aspirin injection test to predict angioplasty outcome in unilateral renovascular hypertension: preliminary report. (1838974)
1991
49
The role of laboratory testing in the diagnosis of renovascular hypertension. (1914198)
1991
50
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. (6767370)
1980

Variations for Renovascular Hypertension

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Expression for genes affiliated with Renovascular Hypertension

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Renovascular Hypertension

Search GEO for disease gene expression data for Renovascular Hypertension.

Pathways for genes affiliated with Renovascular Hypertension

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Sources:
51PathCards, 54QIAGEN, 39NCBI BioSystems Database, 52PharmGKB, 31KEGG, 56Reactome
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Compounds for genes affiliated with Renovascular Hypertension

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 30IUPHAR, 25HMDB, 62Tocris Bioscience
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Compounds related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show top 50)    (show all 260)
idCompoundScoreTop Affiliating Genes
1alacepril469.9NPPA, ACE, REN, NPPB
2lacidipine469.8ACE, EDN1, REN, AGTR1
3bisoprolol46 52 1211.7REN, ACE, NPPA, NPPB
4omapatrilat469.7NPPA, EDN1, REN, ACE
5cilazapril46 1210.7NPPA, REN, EDN1, ACE, AGTR1
6urodilatin469.6EDN1, REN, NPPA, NPPB
7quinapril46 52 1211.6NPPA, ACE, REN, EDN1, AGTR1
8chymostatin469.6EDN1, AGTR1, CMA1, REN, ACE
9hanp469.6NPPA, NPPB, REN, EDN1
10enalaprilat469.6EDN1, REN, NPPB, ACE, NPPA
11atenolol46 52 30 25 1213.5AGTR1, EDN1, ACE, NPPB, REN
12diltiazem46 30 52 1212.5REN, ACE, AGTR1, SERPINC1, EDN1
13isosorbide dinitrate46 52 1211.4NPPA, HMOX1, ACE, EDN1
14trandolapril46 1210.4NPPB, AGTR1, EDN1, REN, ACE, NPPA
15moxonidine469.4REN, ACE, INS, NPPB, NPPA
16carvedilol46 52 30 1212.4REN, AGTR1, NPPA, ACE, EDN1, NPPB
17irbesartan46 30 52 1212.3ACE, AGTR1, ALB, REN, EDN1
18ang ii469.3AGTR1, NPPA, NPPB, ACE, REN, EDN1
19candesartan46 52 30 1212.3REN, ACE, ALB, NPPB, AGTR1
20digoxin46 62 52 25 1213.3NPPB, NPPA, ACE, REN, AGTR1
21fosinopril46 1210.3AGTR1, NPPB, NPPA, ALB, ACE, REN
22lisinopril46 52 25 1212.3NPPA, AGTR1, REN, ACE, ALB, NPPB
23perindopril46 52 1211.3ALB, NPPB, AGTR1, NPPA, REN, ACE
24spironolactone46 62 30 52 1213.2NPPA, NPPB, ACE, REN, AGTR1, ALB
25amlodipine46 52 25 1212.2AGTR1, NPPB, REN, ACE, ALB, NPPA
26furosemide46 62 30 52 25 1214.2ACE, ALB, NPPA, NPPB, AGTR1, REN
27valsartan46 62 30 1212.2REN, EDN1, NPPB, ACE, ALB, AGTR1
28nitroglycerin46 1210.0AGTR1, NPPB, NPPA, EDN1, ACE, REN
29s-nitroso-n-acetylpenicillamine469.0CAT, SOD1, NPPA, HMOX1, NPPB, EDN1
30l-nmma469.0CAT, SOD1, NPPA, NPPB, EDN1, AGTR1
31telmisartan46 30 1211.0REN, INS, AGTR1, NPPB, ALB, ACE
32enalapril46 52 1211.0AGTR1, NPPB, NPPA, ALB, ACE, REN
33captopril46 62 52 30 1213.0EDN1, REN, AGTR1, NPPB, NPPA, ALB
34losartan46 52 30 1211.9NPPB, ALB, EDN1, REN, ACE, AGTR1
35ramipril46 129.8AGTR1, NPPB, NPPA, ALB, REN, INS
36nifedipine46 30 52 1211.7NPPA, HMOX1, ACE, REN, EDN1, AGTR1
378-isoprostane468.5CAT, HMOX1, NPPB, AGTR1, SOD1, INS
38uric acid46 259.5INS, SOD1, CAT, ALB, NPPB, AGTR1
39prostacyclin468.4AGTR1, NPPB, NPPA, EDN1, SERPINC1, SOD1
40sodium nitroprusside468.4NPR2, CAT, REN, SOD1, EDN1, HMOX1
41cgmp46 309.3AGTR1, EDN1, REN, LCN2, HMOX1, NPR2
42indomethacin46 30 62 1211.3ALB, EDN1, SOD1, NPPB, HMOX1, REN
43norepinephrine46 25 1210.1ACE, HMOX1, NPPA, NPPB, S100A6, AGTR1
44rosiglitazone30 46 52 25 1211.8LCN2, AGTR1, ALB, HMOX1, NPPB, INS
45arginine467.5AGTR1, NF1, NPPB, NPPA, HMOX1, EDN1
46cysteine467.3AGTR1, NPPB, HMOX1, NF1, S100A6, ALB
47nitric oxide46 25 129.3NPPB, NPR2, EDN1, NPPA, HMOX1, CAT
48estrogen466.9NPPB, NPPA, S100A6, AGTR1, LCN2, HMOX1
49creatinine466.9EDN1, INS, SERPINC1, SOD1, REN, ACE
50calcium46 52 25 129.5REN, NPPB, NPR2, CMA1, NF1, EDN1

GO Terms for genes affiliated with Renovascular Hypertension

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17Gene Ontology
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Cellular components related to Renovascular Hypertension according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.6CMA1, SOD1, FBN1
2extracellular vesicular exosomeGO:0700627.1SUCNR1, SOD1, ACE, LCN2, ALB, S100A6
3extracellular spaceGO:0056156.2NPPB, EDN1, INS, FBN1, SERPINC1, SOD1
4extracellular regionGO:0055766.2SOD1, SERPINC1, FBN1, INS, EDN1, CMA1

Biological processes related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1renin-angiotensin regulation of aldosterone productionGO:00201810.3AGTR1, REN
2regulation of systemic arterial blood pressure by renin-angiotensinGO:00308110.3AGTR1, ACE
3angiotensin maturationGO:00200310.2CMA1, REN, ACE
4regulation of blood vessel sizeGO:05088010.1NPPA, NPPB
5body fluid secretionGO:00758910.1NPPB, EDN1
6positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.1EDN1, AGTR1
7cGMP biosynthetic processGO:00618210.1NPR2, NPPA, NPPB
8positive regulation of urine volumeGO:03581010.1NPPB, EDN1
9receptor guanylyl cyclase signaling pathwayGO:00716810.1NPPB, NPPA, NPR2
10regulation of vasodilationGO:04231210.1AGTR1, NPPB, ACE
11regulation of vasoconstrictionGO:01922910.0AGTR1, ACE, EDN1
12positive regulation of renal sodium excretionGO:0358159.9EDN1, NPPB
13positive regulation of cellular protein metabolic processGO:0322709.9INS, AGTR1
14superoxide anion generationGO:0425549.9EDN1, SOD1
15regulation of angiogenesisGO:0457659.8HMOX1, NF1
16phosphatidylinositol 3-kinase signalingGO:0140659.7EDN1, NF1
17kidney developmentGO:0018229.6AGTR1, CAT, ACE, REN, FBN1
18heart developmentGO:0075079.5NF1, FBN1, EDN1
19response to hypoxiaGO:0016669.5EDN1, CAT, NF1, NPPA
20cell surface receptor signaling pathwayGO:0071669.4NPPB, NPR2, EDN1
21regulation of blood pressureGO:0082179.0NPPB, SOD1, REN, ACE, HMOX1, NPR2

Molecular functions related to Renovascular Hypertension according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bradykinin receptor bindingGO:03171110.1ACE, AGTR1
2antioxidant activityGO:0162099.7ALB, CAT
3insulin-like growth factor receptor bindingGO:0051599.5REN, INS
4receptor bindingGO:0051029.3REN, CAT, NPPA, NPPB
5hormone activityGO:0051799.3NPPB, NPPA, INS, EDN1
6protease bindingGO:0020208.9LCN2, SERPINC1, INS
7protein homodimerization activityGO:0428038.1SOD1, LCN2, CAT, S100A6, HMOX1

Products for genes affiliated with Renovascular Hypertension

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Renovascular Hypertension

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet