MCID: RPR002
MIFTS: 41

Reproductive System Disease malady

Categories: Reproductive diseases

Aliases & Classifications for Reproductive System Disease

Aliases & Descriptions for Reproductive System Disease:

Name: Reproductive System Disease 12 14
Genital System Disease 12 29
Reproductive System Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:15
NCIt 47 C27613
UMLS 69 C1335037

Summaries for Reproductive System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in reproductive system organs.

MalaCards based summary : Reproductive System Disease, also known as genital system disease, is related to endometriosis and male reproductive system disease. An important gene associated with Reproductive System Disease is AMH (Anti-Mullerian Hormone), and among its related pathways/superpathways are Ovarian steroidogenesis and Follicle Stimulating Hormone (FSH) signaling pathway. The drugs Aripiprazole and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include reproductive system organs, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 71 A reproductive system disease is any disease of the reproductive... more...

Related Diseases for Reproductive System Disease

Diseases related to Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 endometriosis 31.6 GNRH1 PRL
2 male reproductive system disease 12.2
3 female reproductive system disease 12.2
4 uterine disease 10.7
5 ectopic pregnancy 10.7
6 19p13.12 microdeletion syndrome 10.4 DAZ1 DAZL PRL
7 retinitis pigmentosa, y-linked 10.4 DAZ1 DAZ4
8 8p23.1 duplication syndrome 10.4 BMP15 FSHR SRY
9 african histoplasmosis 10.4 GNRH1 PRL
10 parathyroid adenoma 10.4 PRL SRY
11 leydig cell hypoplasia with pseudohermaphroditism 10.4 CYP19A1 FSHR
12 adrenoleukodystrophy 10.4 BMP15 FSHR GDF9
13 gastrointestinal tularemia 10.4 DAZ1 DAZ4 PRL
14 abdominal aortic aneurysm 10.4 PRL SRY
15 polyneuropathy 10.4 CYP19A1 SHBG
16 cone dystrophy 10.4 AMH BMP15 SRY
17 haverhill fever 10.4 CYP19A1 GNRH1 PRL
18 spinocerebellar ataxia 25 10.4 AMH CYP19A1 FSHR GNRH1
19 dystonia-parkinsonism, x-linked 10.4 CYP19A1 SHBG
20 exocervical carcinoma 10.4 KLK3 PRL SHBG
21 hole retinal cyst 10.4 GNRH1 KLK3
22 larynx leiomyoma 10.4 CYP19A1 OXT SERPINH1
23 retroperitoneal sarcoma 10.4 AMH GNRH1 PRL SHBG
24 congenital articular rigidity 10.4 CYP19A1 SHBG SRY
25 diverticulitis 10.3 GNRH1 PRL
26 acute thyroiditis 10.3 CYP19A1 FSHR PRL SHBG
27 viral hepatitis 10.3 KLK3 PRL SHBG
28 esophagus sarcoma 10.3 CYP19A1 KLK3 SRY
29 hypospadias 1, x-linked 10.3 CYP19A1 SHBG SRY
30 46 xx gonadal dysgenesis 10.3 AMH BMP15 FSHR SRY
31 blepharochalasis 10.3 CYP19A1 OXT SERPINH1
32 intermittent squint 10.3 GNRH1 PRL
33 pelvic muscle wasting 10.3 CYP19A1 GNRH1 PRL SHBG
34 gastric teratoma 10.3 PRL SRY
35 mental retardation, x-linked 101 10.3 BMP15 CYP19A1 FSHR GDF9
36 necrobiosis lipoidica 10.3 KLK3 PRL SHBG
37 glioblastoma mesenchymal subtype 10.3 CYP19A1 KLK3 PRL SHBG
38 astroblastoma 10.3 GNRH1 OXT PRL SHBG
39 adult medulloblastoma 10.3 GNRH1 KLK3 SHBG
40 diabetes mellitus, insulin-resistant, with acanthosis nigricans 10.3 AMH DAZ1 DAZ4 GNRH1 SHBG
41 aphasia 10.3 KLK3 OXT PRL SHBG
42 bardet-biedl syndrome 1 10.3 BMP15 CYP19A1
43 vertebral artery occlusion 10.3 GNRH1 PRL
44 intramuscular hemangioma 10.3 AMH BMP15 GNRH1 OXT SRY
45 extragonadal nonseminomatous germ cell tumor 10.3 GNRH1 PRL
46 transient neonatal thrombocytopenia 10.3 DPY19L2 PRL PRM1 PRM2 SHBG
47 gaucher's disease 10.3 AMH CYP19A1 DAZ4 GNRH1 PRL SHBG
48 capillary disease 10.3 CYP19A1 KLK3 PRL SHBG SRY
49 epidural spinal canal meningioma 10.3 BMP15 CYP19A1 FSHR GNRH1 PRL SHBG
50 capillary lymphangioma 10.3 AMH FSHR GNRH1 PRL SHBG SRY

Graphical network of the top 20 diseases related to Reproductive System Disease:



Diseases related to Reproductive System Disease

Symptoms & Phenotypes for Reproductive System Disease

MGI Mouse Phenotypes related to Reproductive System Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 CYP19A1 DPY19L2 FSHR GDF9 GNRH1 OXT
2 reproductive system MP:0005389 9.36 AMH AREG BMP15 CYP19A1 DPY19L2 FSHR

Drugs & Therapeutics for Reproductive System Disease

Drugs for Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1124)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
2
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
3
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
4
Povidone-iodine Approved Phase 4,Phase 3 25655-41-8
5
Acetylcholine Approved Phase 4,Phase 2,Phase 1 51-84-3 187
6
Clindamycin Approved, Vet_approved Phase 4,Phase 3,Phase 1,Early Phase 1 18323-44-9 29029
7
Selenium Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 7782-49-2
8
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
9
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
10
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155213-67-5 392622
11
Acetaminophen Approved Phase 4,Phase 3,Phase 1 103-90-2 1983
12
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 1 616-91-1 12035
13
Metronidazole Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 443-48-1 4173
14
Desogestrel Approved Phase 4,Phase 2 54024-22-5 40973
15
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
16
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-63-6 5991
17
Etonogestrel Approved, Investigational Phase 4,Phase 2,Phase 3 54048-10-1 40976 6917715
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
19
Ganirelix Approved Phase 4,Phase 3,Phase 2 123246-29-7, 124904-93-4 25081094
20
Cetrorelix Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 120287-85-6 16129715 25074887
21
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
22
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
23
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 53714-56-0 3911 657181
24
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
25
Levonorgestrel Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 797-63-7, 17489-40-6 13109
26
Calcium carbonate Approved Phase 4,Phase 3,Phase 1 471-34-1
27
Goserelin Approved Phase 4,Phase 3,Phase 2,Phase 1 65807-02-5 47725 5311128
28
Tibolone Approved Phase 4 5630-53-5
29
Cyproterone Acetate Approved, Investigational Phase 4,Phase 3,Phase 2 427-51-0
30
Tamsulosin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 106133-20-4 129211
31
Tadalafil Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 171596-29-5 110635
32
Azithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1 83905-01-5 55185 53477736 447043
33
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 564-25-0 54671203
34
Lymecycline Approved Phase 4 992-21-2 5280963
35
Tetracycline Approved, Vet_approved Phase 4,Phase 3,Early Phase 1 60-54-8 5353990
36
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
37
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
38
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3 2180-92-9, 38396-39-3 2474
39
Tenofovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 147127-20-6 464205
40
Bicalutamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 90357-06-5 56069 2375
41
Desflurane Approved Phase 4 57041-67-5 42113
42
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
43
Ciprofloxacin Approved, Investigational Phase 4,Phase 3 85721-33-1 2764
44
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1 64-17-5 702
45
Simvastatin Approved Phase 4,Phase 3,Phase 2 79902-63-9 54454
46
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 5460373 44475014
47
Menotropins Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 61489-71-2 5360545
48
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
49
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
50
Buserelin Approved Phase 4,Phase 3 57982-77-1

Interventional clinical trials:

(show top 50) (show all 5000)
id Name Status NCT ID Phase
1 A Multicenter Study to Evaluate the Effects of Switching to Aripiprazole 12 Weeks on the Sexual Dysfunction From Risperidone or Paliperidone in Patients With Schizophrenia Spectrum Disorders or Bipolar Spectrum Disorders Unknown status NCT01742390 Phase 4
2 National,Multicentric Randomised Study of the Correction of Genital Prolapse With Fascial Repair or Mesh-Prolift Unknown status NCT00771225 Phase 4
3 Effect of Fluticasone Proprionate 0.05% on Narrow Band UV-B in Active Vitiligo Unknown status NCT01246921 Phase 4
4 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4
5 Functional Outcome After Groin Hernia Mesh Repair: Open Versus Laparoscopy Unknown status NCT00625534 Phase 4
6 A Prospective Trial of Povidone-iodine Suppository Before Transrectal Ultrasound Guided Prostate Biopsy Unknown status NCT02245334 Phase 4
7 Botox on Vulvar Vestibulitis Unknown status NCT00119886 Phase 4
8 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
9 Primary and Secondary Prevention of Human Papillomavirus (HPV) Disease in China Unknown status NCT01021904 Phase 4
10 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
11 Probiotic Versus Placebo as Adjuvant for Bacterial Vaginosis Treatment During Pregnancy Unknown status NCT01558388 Phase 4
12 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
13 Assessment of the Effectiveness of a Program of Preparation to Pregnancy and Delivery Unknown status NCT01155804 Phase 4
14 Testosterone Patch's Effects on the Cardiovascular System and Libido Unknown status NCT01208038 Phase 4
15 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4
16 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4
17 Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells Unknown status NCT02204358 Phase 4
18 Role of N-Acetylcysteine in Treatment of Bacterial Vaginosis Unknown status NCT01841411 Phase 4
19 Effect of the Etonogestrel 0.12mg/Ethinyl Estradiol 0.015mg Vaginal Ring on Vaginal Innate and Inflammatory Biomarkers Unknown status NCT01448291 Phase 4
20 Probiotics Capsule as Supplemental Therapy for Group B Streptococci Infection and Vaginitis During Pregnancy Unknown status NCT01779193 Phase 4
21 Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain Unknown status NCT00844012 Phase 4
22 Ovarian Stimulation: Inositol and Melatonin Unknown status NCT01267604 Phase 4
23 Ovulation Induction With Clomiphene Citrate and Dexamethasone Unknown status NCT01856062 Phase 4
24 Corifollitropin Alfa Versus Follitropin Beta in High Responders Unknown status NCT02471677 Phase 4
25 Type of Gonadotropin and Embryo Kinetics of Development Unknown status NCT02402192 Phase 4
26 Intrauterine Injection of Human Chorionic Gonadotropin Before Embryo Transfer in Women With Previous IVF Failure Unknown status NCT02329197 Phase 4
27 Long Acting FSH Plus Antagonist Versus Daily FSH Plus Antagonist Versus Short Agonist Protocol in Poor Responders Undergoing IVF Unknown status NCT02070198 Phase 4
28 IUI vs. IVF/ICSI in Women Aged 38-42 Years: a Prospective Randomized Controlled Trial. Unknown status NCT01992731 Phase 4
29 Comparison of Ovarian Mild Stimulation and Controlled Ovarian Stimulation in Poor Ovarian Responders Unknown status NCT01926210 Phase 4
30 Physical Activity and ARTs Unknown status NCT01892111 Phase 4
31 Intrauterine Insemination and Luteal Fase Support Unknown status NCT01826747 Phase 4
32 Study of Dual Trigger Ovulation in Oocyte Donors Unknown status NCT01443546 Phase 4
33 Metformin in Step-down Regimen Versus Conventional Low Dose Step-up Protocol in Patients With PCOS Undergoing IVF Unknown status NCT01438190 Phase 4
34 Comparison Between Natural and Artificial Cycle in Recipient Oocyte Patients Unknown status NCT01353846 Phase 4
35 Luteal Phase Support With Progesterone Versus Estrogen and Progesterone on Pregnancy Rates Unknown status NCT01237535 Phase 4
36 Comparison of the Long GnRH Agonist Protocol and the Flexible GnRH Antagonist Protocol of Ovarian Stimulation Unknown status NCT00417183 Phase 4
37 Comparison Between hCG and GnRH Agonist for Ovulation Induction in Patients With High Response to IVF Drugs Unknown status NCT00415792 Phase 4
38 The Effect of LH-Priming During Early Follicular Phase in IVF Treatment. Unknown status NCT00334425 Phase 4
39 Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis Unknown status NCT02480647 Phase 4
40 Does the HPV Vaccine Cause the Same Response in Adolescent Kidney and Liver Transplant Patients as in Healthy Controls? Unknown status NCT01101750 Phase 4
41 Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis Unknown status NCT00654524 Phase 4
42 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4
43 Correlation Among Sperm DNA Fragmentation, Genitourinary Infection by Mycoplasma in Male and the Pregnancy Outcomes After IUI in Their Partner Unknown status NCT01555047 Phase 4
44 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4
45 Treatment of Phimosis With Topical Steroid Cream -Double-blind, Randomized, Placebo-controlled Study Unknown status NCT01108198 Phase 4
46 Efficacy and Safety of Naftopidil in Patient With Neurogenic Lower Urinary Tract Dysfunction Not Caused by Benign Prostatic Hyperplasia Unknown status NCT02034604 Phase 4
47 Evaluation of Safety and Effectiveness of 2 Lower Dose Combined PDE5i's Versus Single Maximal Dose PDE5i Treatment Unknown status NCT01364701 Phase 4
48 Time to Eradication of Mycoplasma Genitalium and Chlamydia Trachomatis After Treatment Commenced Unknown status NCT01661985 Phase 4
49 Less Chronic Pain After Lichtenstein Hernioplasty Using the Self-gripping Parietex Progrip Mesh Unknown status NCT01830452 Phase 4
50 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4

Search NIH Clinical Center for Reproductive System Disease

Genetic Tests for Reproductive System Disease

Genetic tests related to Reproductive System Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Genital System 29

Anatomical Context for Reproductive System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive System Disease:

18
Reproductive System Organs

Publications for Reproductive System Disease

Variations for Reproductive System Disease

Expression for Reproductive System Disease

Search GEO for disease gene expression data for Reproductive System Disease.

Pathways for Reproductive System Disease

Pathways related to Reproductive System Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.96 BMP15 CYP19A1 FSHR GDF9
2 10.76 AREG CYP19A1 FSHR
3 10.58 GNRH1 SHBG
4 10.53 CYP19A1 DAZL FSHR GDF9 ZP3
5 10.37 FSHR GNRH1

GO Terms for Reproductive System Disease

Cellular components related to Reproductive System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 AMH BMP15 GDF9 GNRH1 KLK3 OXT
2 extracellular space GO:0005615 9.28 AMH AREG BMP15 GDF9 GNRH1 KLK3
3 secretory granule GO:0030141 9.13 OXT PRL ZP3

Biological processes related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.76 AMH DAZ1 DAZ4 DAZL DPY19L2 PRM1
2 response to estradiol GO:0032355 9.74 AREG OXT PRL
3 female pregnancy GO:0007565 9.72 GNRH1 OXT PRL
4 BMP signaling pathway GO:0030509 9.7 AMH BMP15 GDF9
5 spermatid development GO:0007286 9.69 DPY19L2 FSHR PRM2
6 sex differentiation GO:0007548 9.6 AMH SRY
7 female gonad development GO:0008585 9.59 CYP19A1 FSHR
8 chromosome condensation GO:0030261 9.58 PRM1 PRM2
9 uterus development GO:0060065 9.58 CYP19A1 FSHR
10 response to peptide hormone GO:0043434 9.58 AREG GNRH1 OXT
11 positive regulation of translational initiation GO:0045948 9.56 DAZ1 DAZL
12 gonad development GO:0008406 9.54 AMH FSHR
13 regulation of MAPK cascade GO:0043408 9.5 BMP15 FSHR GDF9
14 male sex determination GO:0030238 9.49 GNRH1 SRY
15 ovulation cycle GO:0042698 9.48 GNRH1 PRL
16 response to prostaglandin E GO:0034695 9.43 GNRH1 OXT
17 female gamete generation GO:0007292 9.43 BMP15 FSHR GDF9
18 DNA packaging GO:0006323 9.37 PRM1 PRM2
19 response to organic cyclic compound GO:0014070 9.35 AMH AREG GNRH1 OXT PRL
20 spermatogenesis GO:0007283 9.17 DAZ1 DAZ4 DAZL DPY19L2 FSHR PRM1
21 multicellular organism development GO:0007275 10 DAZ1 DAZ4 DAZL DPY19L2 GNRH1 PRM1

Molecular functions related to Reproductive System Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 AMH AREG BMP15 GDF9
2 translation activator activity GO:0008494 9.26 DAZ1 DAZL
3 transforming growth factor beta receptor binding GO:0005160 9.13 AMH BMP15 GDF9
4 hormone activity GO:0005179 8.92 AMH GNRH1 OXT PRL

Sources for Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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