MCID: RPR002
MIFTS: 33

Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Reproductive System Disease

MalaCards integrated aliases for Reproductive System Disease:

Name: Reproductive System Disease 12 14
Abnormality of the Genital System 28
Reproductive System Disorder 69
Genital System Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:15
NCIt 46 C27613

Summaries for Reproductive System Disease

Disease Ontology : 12 A disease of anatomical entity that is located in reproductive system organs.

MalaCards based summary : Reproductive System Disease, also known as abnormality of the genital system, is related to male reproductive system disease and female reproductive system disease. An important gene associated with Reproductive System Disease is AMH (Anti-Mullerian Hormone), and among its related pathways/superpathways are Ovarian steroidogenesis and Follicle Stimulating Hormone (FSH) signaling pathway. The drugs insulin and Hormones have been mentioned in the context of this disorder. Affiliated tissues include reproductive system organs, and related phenotypes are endocrine/exocrine gland and reproductive system

Wikipedia : 72 A reproductive system disease is any disease of the reproductive... more...

Related Diseases for Reproductive System Disease

Diseases related to Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 male reproductive system disease 33.6 DAZ1 DAZ4 DAZL DPY19L2 FSHR KLK3
2 female reproductive system disease 33.3 AMH AREG BMP15 CYP19A1 FSHR GDF9
3 aromatase excess syndrome 10.8
4 uterine anomalies 10.8
5 ectopic pregnancy 10.8
6 endometriosis 10.8
7 partial deletion of y 10.7 DAZ1 DAZ4
8 pituitary infarct 10.7 GNRH1 PRL
9 freemartinism 10.7 AMH BMP15 GNRH1
10 spermatogenic failure, x-linked, 1 10.7 DAZ1 DAZ4 DAZL
11 endometriosis of uterus 10.6 GNRH1 PRL
12 precocious puberty, male-limited 10.6 CYP19A1 FSHR
13 hypogonadotropism 10.6 GNRH1 PRL
14 oligospermia 10.6 DAZ1 DAZ4 PRL
15 hypoactive sexual desire disorder 10.6 CYP19A1 SHBG
16 premenstrual tension 10.6 GNRH1 PRL SHBG
17 hypothalamic disease 10.6 GNRH1 PRL
18 oocyte maturation defect 1 10.6 BMP15 CYP19A1
19 gonadal dysgenesis 10.6 AMH BMP15 FSHR
20 mccune-albright syndrome 10.6 AMH CYP19A1 PRL
21 chiasmal syndrome 10.6 GNRH1 PRL
22 estrogen excess 10.6 CYP19A1 FSHR SHBG
23 prostatic adenoma 10.6 KLK3 PRL SHBG
24 gonadal disease 10.6 AMH FSHR GNRH1 SHBG
25 varicocele 10.6 AMH GNRH1 PRL SHBG
26 sexual disorder 10.6 KLK3 PRL SHBG
27 ovarian hyperstimulation syndrome 10.6 AMH CYP19A1 FSHR GNRH1
28 impotence 10.6 KLK3 PRL SHBG
29 acquired metabolic disease 10.5 PRL SHBG TRPV1
30 breast disease 10.5 KLK3 PRL SHBG
31 nodular prostate 10.5 GNRH1 KLK3
32 androgen insensitivity, partial 10.5 CYP19A1 SHBG
33 hyperandrogenism 10.5 CYP19A1 GNRH1 PRL SHBG
34 pelvic varices 10.5 DPY19L2 GNRH1 PRM1 SHBG
35 46,xx sex reversal 1 10.5 BMP15 FSHR
36 pituitary apoplexy 10.5 GNRH1 PRL
37 focal epilepsy 10.5 PRL SHBG TRPV1
38 androgenic alopecia 10.5 CYP19A1 KLK3 PRL SHBG
39 gynecomastia 10.5 CYP19A1 KLK3 PRL SHBG
40 cryptorchidism, unilateral or bilateral 10.5 AMH CYP19A1 DAZ1 GNRH1 SHBG
41 sex differentiation disease 10.5 AMH CYP19A1 GNRH1 PRL SHBG
42 amenorrhea 10.5 BMP15 FSHR GNRH1 PRL SHBG
43 empty sella syndrome 10.5 GNRH1 PRL
44 male reproductive organ cancer 10.4 AREG GNRH1 KLK3 SHBG TRPV1
45 male infertility 10.4 DAZ1 DAZ4 DAZL FSHR PRM1 PRM2
46 anovulation 10.4 BMP15 CYP19A1 FSHR GNRH1 PRL SHBG
47 polycystic ovary syndrome 10.4 CYP19A1 FSHR GDF9 GNRH1 PRL SHBG
48 azoospermia 10.4 DAZ1 DAZ4 DAZL
49 alopecia, androgenetic, 1 10.3 CYP19A1 SHBG
50 mammographic density 10.2 CYP19A1 PRL

Graphical network of the top 20 diseases related to Reproductive System Disease:



Diseases related to Reproductive System Disease

Symptoms & Phenotypes for Reproductive System Disease

MGI Mouse Phenotypes related to Reproductive System Disease:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.65 GDF9 GNRH1 PRL ZP3 AMH AREG
2 reproductive system MP:0005389 9.32 GDF9 GNRH1 PRL ZP3 AMH AREG

Drugs & Therapeutics for Reproductive System Disease

Drugs for Reproductive System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin
2 Hormones
3 Insulin, Globin Zinc

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Modifications of Nutritional Intake Upon Reproductive Hormones in Normal Women Completed NCT02233283
2 Inherited Reproductive Disorders Recruiting NCT01500447

Search NIH Clinical Center for Reproductive System Disease

Genetic Tests for Reproductive System Disease

Genetic tests related to Reproductive System Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Genital System 28

Anatomical Context for Reproductive System Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Reproductive System Disease:

18
Reproductive System Organs

Publications for Reproductive System Disease

Variations for Reproductive System Disease

Expression for Reproductive System Disease

Search GEO for disease gene expression data for Reproductive System Disease.

Pathways for Reproductive System Disease

Pathways related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 BMP15 CYP19A1 FSHR GDF9
2 10.76 AREG CYP19A1 FSHR
3 10.58 GNRH1 SHBG
4 10.53 CYP19A1 DAZL FSHR GDF9 ZP3
5 10.37 FSHR GNRH1

GO Terms for Reproductive System Disease

Cellular components related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 AMH AREG BMP15 GDF9 GNRH1 KLK3

Biological processes related to Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.76 AMH DAZ1 DAZ4 DAZL DPY19L2 PRM1
2 response to organic cyclic compound GO:0014070 9.74 AMH AREG GNRH1
3 BMP signaling pathway GO:0030509 9.71 AMH BMP15 GDF9
4 spermatid development GO:0007286 9.69 DPY19L2 FSHR PRM2
5 response to peptide hormone GO:0043434 9.65 AREG GNRH1 TRPV1
6 regulation of MAPK cascade GO:0043408 9.61 BMP15 FSHR GDF9
7 germ cell development GO:0007281 9.58 DAZ1 DAZ4 DAZL
8 chromosome condensation GO:0030261 9.56 PRM1 PRM2
9 uterus development GO:0060065 9.55 CYP19A1 FSHR
10 female gamete generation GO:0007292 9.54 BMP15 FSHR GDF9
11 gonad development GO:0008406 9.52 AMH FSHR
12 positive regulation of translational initiation GO:0045948 9.5 DAZ1 DAZ4 DAZL
13 regulation of receptor activity GO:0010469 9.5 AMH AREG BMP15 GDF9 GNRH1 PRL
14 DNA packaging GO:0006323 9.46 PRM1 PRM2
15 3-UTR-mediated mRNA stabilization GO:0070935 9.43 DAZ1 DAZ4 DAZL
16 spermatogenesis GO:0007283 9.23 DAZ1 DAZ4 DAZL DPY19L2 FSHR PRM1
17 multicellular organism development GO:0007275 10.04 DAZ1 DAZ4 DAZL DPY19L2 GNRH1 PRM1

Molecular functions related to Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding GO:0003729 9.54 DAZ1 DAZ4 DAZL
2 hormone activity GO:0005179 9.5 AMH GNRH1 PRL
3 growth factor activity GO:0008083 9.46 AMH AREG BMP15 GDF9
4 mRNA 3-UTR binding GO:0003730 9.43 DAZ1 DAZ4 DAZL
5 transforming growth factor beta receptor binding GO:0005160 9.13 AMH BMP15 GDF9
6 translation activator activity GO:0008494 8.8 DAZ1 DAZ4 DAZL

Sources for Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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