RDS
MCID: RSP019
MIFTS: 43

Respiratory Distress Syndrome in Premature Infants (RDS) malady

Categories: Respiratory diseases, Rare diseases

Aliases & Classifications for Respiratory Distress Syndrome in Premature Infants

Aliases & Descriptions for Respiratory Distress Syndrome in Premature Infants:

Name: Respiratory Distress Syndrome in Premature Infants 54 66 29
Hyaline Membrane Disease 56 66 69
Infant Acute Respiratory Distress Syndrome 56
Neonatal Respiratory Distress Syndrome 56
Respiratory Distress Syndrome, Newborn 69
Infant Respiratory Distress Syndrome 56
Rds in Prematurity 66
Infant Ards 56
Rds 66

Characteristics:

Orphanet epidemiological data:

56
infant acute respiratory distress syndrome
Inheritance: Not applicable; Prevalence: 1-5/10000 (Europe); Age of onset: Infancy,Neonatal;

HPO:

32
respiratory distress syndrome in premature infants:
Inheritance multifactorial inheritance sporadic
Onset and clinical course congenital onset


Classifications:

Orphanet: 56  
Rare respiratory diseases


External Ids:

OMIM 54 267450
Orphanet 56 ORPHA70587
ICD10 via Orphanet 34 P22.0
MedGen 40 C1968593
MeSH 42 D006819

Summaries for Respiratory Distress Syndrome in Premature Infants

OMIM : 54 The main cause of respiratory distress syndrome (RDS) in premature infants is a developmental deficiency of pulmonary... (267450) more...

MalaCards based summary : Respiratory Distress Syndrome in Premature Infants, also known as hyaline membrane disease, is related to choreoathetosis, hypothyroidism, and neonatal respiratory distress and reticular dysgenesis, and has symptoms including respiratory distress, atelectasis and premature birth. An important gene associated with Respiratory Distress Syndrome in Premature Infants is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are HIV Life Cycle and Diseases of metabolism. The drugs Epinephrine and Midazolam have been mentioned in the context of this disorder. Affiliated tissues include lung, and related phenotype is respiratory system.

UniProtKB/Swiss-Prot : 66 Respiratory distress syndrome in premature infants: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high- permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'.

Wikipedia : 71 Infant respiratory distress syndrome (IRDS), also called neonatal respiratory distress... more...

Related Diseases for Respiratory Distress Syndrome in Premature Infants

Diseases related to Respiratory Distress Syndrome in Premature Infants via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
id Related Disease Score Top Affiliating Genes
1 choreoathetosis, hypothyroidism, and neonatal respiratory distress 11.8
2 reticular dysgenesis 11.4
3 newborn respiratory distress syndrome 11.4
4 respiratory distress syndrome, infant 11.2
5 interstitial emphysema 10.1
6 osteochondritis dissecans 10.0 SFTPB SFTPC
7 conjunctivochalasis 10.0 SFTPB SFTPC
8 neurotrophic keratoconjunctivitis 10.0 SFTPB SFTPC
9 imperforate anus 10.0 SFTPB SFTPC
10 adnp syndrome 10.0 SFTPB SFTPC
11 skull base neoplasm 10.0 SFTPB SFTPC
12 patent ductus arteriosus 10.0
13 pulmonary fibrosis and/or bone marrow failure, telomere-related, 1 10.0 SFTPB SFTPC
14 scn9a-related inherited erythromelalgia 9.9 SFTPA1 SFTPC
15 anogenital venereal wart 9.9 SFTPB SFTPC
16 nervous system cancer 9.9 SFTPB SFTPC
17 subcorneal pustular dermatosis 9.9 SFTPB SFTPC
18 malignant neoplasm of acoustic nerve 9.9 SFTPA1 SFTPC
19 bronchopulmonary dysplasia 9.8
20 renal tubular acidosis 9.8 SFTPA1 SFTPC
21 rectum squamous cell carcinoma 9.8 SFTPB SFTPC
22 ectodermal dysplasia with natal teeth, turnpenny type 9.7 SFTPA1 SFTPB SFTPC
23 common wart 9.7 SFTPA1 SFTPB SFTPC
24 back pain 9.7 SFTPA1 SFTPB SFTPC
25 renal tubular dysgenesis, agt-related 9.7 SFTPA1 SFTPB SFTPC
26 aortic aneurysm, familial thoracic 6 9.7 SFTPA1 SFTPB SFTPC
27 aspiration pneumonia 9.7
28 chorioamnionitis 9.7
29 pneumothorax 9.7
30 neonatal jaundice 9.7
31 pneumonia 9.7

Graphical network of the top 20 diseases related to Respiratory Distress Syndrome in Premature Infants:



Diseases related to Respiratory Distress Syndrome in Premature Infants

Symptoms & Phenotypes for Respiratory Distress Syndrome in Premature Infants

Symptoms by clinical synopsis from OMIM:

267450

Clinical features from OMIM:

267450

Human phenotypes related to Respiratory Distress Syndrome in Premature Infants:

32 (show all 7)
id Description HPO Frequency HPO Source Accession
1 respiratory distress 32 HP:0002098
2 atelectasis 32 HP:0100750
3 premature birth 32 HP:0001622
4 tachypnea 32 HP:0002789
5 neonatal respiratory distress 32 HP:0002643
6 pulmonary edema 32 HP:0100598
7 disseminated intravascular coagulation 32 HP:0005521

UMLS symptoms related to Respiratory Distress Syndrome in Premature Infants:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress

MGI Mouse Phenotypes related to Respiratory Distress Syndrome in Premature Infants:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.8 SFTPA1 SFTPB SFTPC

Drugs & Therapeutics for Respiratory Distress Syndrome in Premature Infants

Drugs for Respiratory Distress Syndrome in Premature Infants (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 286)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
2
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
3
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
4
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
5
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
6
Budesonide Approved Phase 4,Phase 2 51333-22-3 63006 5281004
7
Remifentanil Approved Phase 4 132875-61-7 60815
8
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
9
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
10 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
11 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
12
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
13
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
14
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
15
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
16
Carbon monoxide Approved Phase 4,Phase 1 630-08-0 281
17
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
18
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
19 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
20
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
21 Cisatracurium Phase 4,Phase 3
22 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
23 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
24 glucocorticoids Phase 4,Phase 3,Phase 2
25 Adjuvants, Anesthesia Phase 4,Phase 3
26 GABA Agents Phase 4,Phase 3
27 GABA Modulators Phase 4,Phase 3
28 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1
29 Neuromuscular Agents Phase 4,Phase 1,Phase 2
30 Neuromuscular Blocking Agents Phase 4,Phase 3,Phase 1,Phase 2
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Cortisol succinate Phase 4,Phase 2
33 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2
35 Tranquilizing Agents Phase 4,Phase 3
36 Anesthetics Phase 4,Phase 3
37 Hormones Phase 4,Phase 3,Phase 2
38 Anesthetics, General Phase 4,Phase 3
39 Anesthetics, Intravenous Phase 4,Phase 3
40 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2
42 Hydrocortisone 17-butyrate 21-propionate Phase 4,Phase 2
43 Hydrocortisone acetate Phase 4,Phase 2
44 Epinephryl borate Phase 4
45 Hydrocortisone-17-butyrate Phase 4,Phase 2
46 Anti-Anxiety Agents Phase 4,Phase 3
47 Hypnotics and Sedatives Phase 4,Phase 3
48 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Antiemetics Phase 4,Phase 3,Phase 2
50 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 581)
id Name Status NCT ID Phase
1 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4
2 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
3 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
4 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4
5 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
6 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4
7 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4
8 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4
9 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4
10 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
11 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4
12 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4
13 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
14 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
15 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
16 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4
17 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4
18 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
19 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
20 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
21 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4
22 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4
23 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4
24 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
25 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4
26 Corticosteroid Mediates Acute Respiratory Distress Syndrome Recruiting NCT02819453 Phase 4
27 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4
28 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4
29 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4
30 Exogenous Surfactant in Very Preterm Neonates in Prevention of Bronchopulmonary Dysplasia Active, not recruiting NCT01039285 Phase 4
31 The Use of Maternal Serum Unconjugated Estriol for Monitoring the Prevention of Neonatal Respiratory Distress Syndrome Active, not recruiting NCT02112513 Phase 4
32 Sleep Intervention During Acute Lung Injury Active, not recruiting NCT01050699 Phase 4
33 NIPPV and nBiPAP Methods in Preterm Infants With Respiratory Distress Syndrome Not yet recruiting NCT02901652 Phase 4
34 SLI MANEUVER and RESPIRATORY MORBIDITIES Not yet recruiting NCT02887924 Phase 4
35 Curosurf and Survanta Treatment(CAST)of RDS in Very Premature Infants Terminated NCT00767039 Phase 4
36 Cytokine Change in Bronchoalveolar Lavage Fluid After Early Budesonide-Surfactant Treatment in Premature Infants Terminated NCT00146497 Phase 4
37 Antenatal Rescue Course of Glucocorticoids in Threatened Premature Birth Terminated NCT00295464 Phase 4
38 Removal Versus Retention of Cerclage in Preterm Premature Rupture of Membranes (PPROM) Terminated NCT00201656 Phase 4
39 (S5-SAMU) Randomized Study Comparing the ASV (Adaptative Support Ventilation) to Conventional Ventilation Terminated NCT02348047 Phase 4
40 Pre Hospital Evaluation of Video Laryngoscopy Withdrawn NCT01374061 Phase 4
41 Intranasal Midazolam Versus Intranasal Ketamine to Sedate Newborns for Intubation in Delivery Room Unknown status NCT01517828 Phase 3
42 Intratracheal Vitamin A Administration With Surfactant for Newborn Respiratory Distress Syndrome Unknown status NCT01265589 Phase 3
43 Comparison Study of High Frequency Percussive Ventilation With Conventional Ventilation Unknown status NCT00308022 Phase 2, Phase 3
44 A Validation/Interventional Study on Stress Index in Predicting Mechanical Stress in ARDS Patients Unknown status NCT00465374 Phase 3
45 NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome) Completed NCT02259400 Phase 2, Phase 3
46 Delivery Room Management Trial of Premature Infants at High Risk of Respiratory Distress Syndrome Completed NCT00244101 Phase 3
47 A Multicenter, Randomized, Open Label Trial of a New Animal Extracted Surfactant to Treat RDS in Preterm Infants Completed NCT02305160 Phase 2, Phase 3
48 A Multi-center Trial to Determine if Curosurf® Reduces the Duration of Mechanical Ventilation in Very Preterm Infants Completed NCT01709409 Phase 3
49 Very Early Surfactant and NCPAP for Premature Infants With RDS Completed NCT00563641 Phase 3
50 Follow-up at School-age of Children Who Participated in the Efficacy Study of Nitric Oxide for Premature Infants Completed NCT00152542 Phase 3

Search NIH Clinical Center for Respiratory Distress Syndrome in Premature Infants

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Respiratory Distress Syndrome in Premature Infants

Genetic tests related to Respiratory Distress Syndrome in Premature Infants:

id Genetic test Affiliating Genes
1 Respiratory Distress Syndrome in Premature Infants 29

Anatomical Context for Respiratory Distress Syndrome in Premature Infants

MalaCards organs/tissues related to Respiratory Distress Syndrome in Premature Infants:

39
Lung

Publications for Respiratory Distress Syndrome in Premature Infants

Articles related to Respiratory Distress Syndrome in Premature Infants:

(show all 20)
id Title Authors Year
1
The role of surfactant and non-invasive mechanical ventilation in early management of respiratory distress syndrome in premature infants. ( 25124970 )
2014
2
Early surfactant for respiratory distress syndrome in premature infants. ( 24049954 )
2013
3
Lucinactant for the prevention of respiratory distress syndrome in premature infants. ( 23473590 )
2013
4
Observational study to compare the clinical efficacy of the natural surfactants Alveofact and Curosurf in the treatment of respiratory distress syndrome in premature infants. ( 16698258 )
2007
5
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants, by G. C. Liggins, MB, PhD, FRCOG, and R. N. Howie, MB, MRACP, Pediatrics, 1972;50:515-525. ( 9651447 )
1998
6
Prenatal ritodrine administration and the incidence of respiratory distress syndrome in premature infants. ( 9134506 )
1997
7
Antenatal ambroxol treatment does not prevent the respiratory distress syndrome in premature infants. ( 9177984 )
1997
8
Synthetic surfactant for rescue treatment of respiratory distress syndrome in premature infants weighing from 700 to 1350 grams: impact on hospital resource use and charges. ( 7815233 )
1995
9
A preliminary report of prenatal cocaine exposure and respiratory distress syndrome in premature infants. ( 2035498 )
1991
10
Exogenous surfactant for treatment of respiratory distress syndrome in premature infants. ( 1973717 )
1990
11
Effects of postnatal aminophylline on the course of respiratory distress syndrome in premature infants. ( 3731212 )
1986
12
The prevention of respiratory distress syndrome in premature infants: efficacy of antenatal aminophylline treatment versus prenatal glucocorticoid administration. ( 6739183 )
1984
13
An analysis of the factors associated with respiratory distress syndrome in premature infants whose mothers had been given dexamethasone therapy. ( 7426540 )
1980
14
Antepartum aminophylline treatment for prevention of the respiratory distress syndrome in premature infants. ( 582496 )
1979
15
Relation of amniotic fluid lecithin/sphingomyelin ratio and fetal asphyxia to respiratory distress syndrome in premature infants. ( 657031 )
1978
16
Effect of antenatal glucocorticoid administered in a single dose on the incidence of respiratory distress syndrome in premature infants. ( 581109 )
1978
17
Patent ductus arteriosus ligation and respiratory distress syndrome in premature infants. ( 973762 )
1976
18
Prevention of the respiratory distress syndrome in premature infants by antepartum glucocorticoid therapy. ( 943175 )
1976
19
Ligation of patent ductus arteriosus for persistent respiratory distress syndrome in premature infants. ( 4843981 )
1974
20
A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. ( 4561295 )
1972

Variations for Respiratory Distress Syndrome in Premature Infants

ClinVar genetic disease variations for Respiratory Distress Syndrome in Premature Infants:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806

Expression for Respiratory Distress Syndrome in Premature Infants

Search GEO for disease gene expression data for Respiratory Distress Syndrome in Premature Infants.

Pathways for Respiratory Distress Syndrome in Premature Infants

Pathways related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 SFTPA1 SFTPB SFTPC
2
Show member pathways
11.31 SFTPA1 SFTPB SFTPC
3 11.06 SFTPA1 SFTPC
4
Show member pathways
10.77 SFTPA1 SFTPB SFTPC
5
Show member pathways
10.2 SFTPA1 SFTPB SFTPC

GO Terms for Respiratory Distress Syndrome in Premature Infants

Cellular components related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.54 SFTPA1 SFTPB SFTPC
2 extracellular space GO:0005615 9.5 SFTPA1 SFTPB SFTPC
3 endoplasmic reticulum membrane GO:0005789 9.43 SFTPA1 SFTPB SFTPC
4 multivesicular body lumen GO:0097486 9.16 SFTPB SFTPC
5 clathrin-coated endocytic vesicle GO:0045334 9.13 SFTPA1 SFTPB SFTPC
6 lamellar body GO:0042599 8.8 SFTPA1 SFTPB SFTPC

Biological processes related to Respiratory Distress Syndrome in Premature Infants according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.13 SFTPA1 SFTPB SFTPC
2 respiratory gaseous exchange GO:0007585 8.8 SFTPA1 SFTPB SFTPC

Sources for Respiratory Distress Syndrome in Premature Infants

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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