MCID: RSP007
MIFTS: 28

Respiratory Distress Syndrome, Infant

Categories: Rare diseases

Aliases & Classifications for Respiratory Distress Syndrome, Infant

MalaCards integrated aliases for Respiratory Distress Syndrome, Infant:

Name: Respiratory Distress Syndrome, Infant 49
Hyaline Membrane Disease 49 69
Rds - Infants 49 69
Infantile Respiratory Distress Syndrome 49
Neonatal Respiratory Distress Syndrome 49
Respiratory Distress Syndrome, Newborn 69
Irds 49
Nrds 49

Classifications:



External Ids:

Summaries for Respiratory Distress Syndrome, Infant

MalaCards based summary : Respiratory Distress Syndrome, Infant, also known as hyaline membrane disease, is related to choreoathetosis and congenital hypothyroidism with or without pulmonary dysfunction and peroxisome biogenesis disorder 1b, and has symptoms including respiratory distress, hoarseness and hemoptysis. The drugs Infasurf and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and liver.

Related Diseases for Respiratory Distress Syndrome, Infant

Graphical network of the top 20 diseases related to Respiratory Distress Syndrome, Infant:



Diseases related to Respiratory Distress Syndrome, Infant

Symptoms & Phenotypes for Respiratory Distress Syndrome, Infant

UMLS symptoms related to Respiratory Distress Syndrome, Infant:


respiratory distress, hoarseness, hemoptysis, dyspnea, coughing, cheyne-stokes respiration, apnea

Drugs & Therapeutics for Respiratory Distress Syndrome, Infant

FDA approved drugs:

# Drug Name Active Ingredient(s) 17 Company Approval Date
1
Infasurf 17 CALFACTANT ONY July 1998

Drugs for Respiratory Distress Syndrome, Infant (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 393)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
3
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
4
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
5
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
6
Metformin Approved Phase 4 657-24-9 4091 14219
7
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
8
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 657311 5754
9
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
10
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
11
Budesonide Approved Phase 4,Phase 2 51333-22-3 5281004 63006
12 Cisatracurium Approved, Experimental Phase 4,Phase 3 96946-41-7
13
Remifentanil Approved Phase 4 132875-61-7 60815
14
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
15
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
16
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
17
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
18
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
19
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
20
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
21 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
22
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
23 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
24 Racepinephrine Approved Phase 4,Phase 2 329-65-7
25
Carbon monoxide Approved, Investigational Phase 4,Phase 1 630-08-0 281
26 Nefopam Approved, Investigational Phase 4 13669-70-0
27
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
28
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
29
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
30
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
31
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
32
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
33
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
34
Misoprostol Approved Phase 4 59122-46-2 5282381
35 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
36
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 1406-16-2
37
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
38
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3 50-14-6 5280793
39
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
40
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 3 67-97-0 10883523 5280795 6221
41
B-Carotene Approved, Nutraceutical Phase 4 7235-40-7 5280489
42
Butyric Acid Experimental, Investigational Phase 4,Phase 3,Phase 2 107-92-6 264
43 Sivelestat Investigational Phase 4,Phase 1,Phase 2 127373-66-4
44 Prednisolone acetate Phase 4,Phase 2,Phase 3
45 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
46 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
47 glucocorticoids Phase 4,Phase 2,Phase 3
48
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1
49 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
50 Methylprednisolone acetate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 1013)

# Name Status NCT ID Phase Drugs
1 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4 propofol
2 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
3 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4 NIMBEX;NIMBEX
4 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
5 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4 hydrocortisone;placebo
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4 Surfactant
7 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4 budesonide;surfactant and air (placebo)
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4 6-methyl-prednisolone
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
14 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
15 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
16 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
17 Corticosteroid Mediates Acute Respiratory Distress Syndrome Completed NCT02819453 Phase 4 Methylprednisolone
18 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4 Remifentanil
19 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
20 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4 exogenous surfactant
21 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
22 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
23 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4 sevoflurane;midazolam
24 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4 Poractant alfa (Curosurf®)
25 Caesarean and Corticotherapy Completed NCT00446953 Phase 4 betamethasone
26 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4 Rocuronium
27 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
28 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
29 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
30 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
31 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4 Progesterone
32 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4 Hydrocortisone;Saline
33 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
34 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Completed NCT03026777 Phase 4 intravenous crystalloid fluid, 500 mL
35 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
36 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4 17 alpha-hydroxyprogesterones caproate
37 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
38 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
39 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
40 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4 Sivelestat sodium hydrate;Sivelestat sodium hydrate
41 The Effect of β-Carotene, Vitamin D3 and Zinc on Hyaline Membrane Disease and Feeding Intolerance in Premature Neonates Recruiting NCT03366584 Phase 4 Dexamethasone
42 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4 Dexamethasone
43 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4 remifentanil
44 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4 4% albumin
45 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4 Betamethasone;saline
46 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM Recruiting NCT02673359 Phase 4 Progesterone
47 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4 Dexmedetomidine
48 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
49 Handling Oxygenation Targets in the Intensive Care Unit Recruiting NCT03174002 Phase 4 Oxygen;Oxygen
50 Cervical Cerclage for Preventing Spontaneous Preterm Birth in Singleton Pregnancies Without Prior Spontaneous Preterm Birth and With Short Transvaginal Ultrasound Cervical Length Recruiting NCT02746900 Phase 4

Search NIH Clinical Center for Respiratory Distress Syndrome, Infant

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Respiratory Distress Syndrome, Infant

Anatomical Context for Respiratory Distress Syndrome, Infant

MalaCards organs/tissues related to Respiratory Distress Syndrome, Infant:

38
Lung, Brain, Liver, Fetal Lung, Testes, Cervix, Heart

Publications for Respiratory Distress Syndrome, Infant

Articles related to Respiratory Distress Syndrome, Infant:

# Title Authors Year
1
Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants. ( 23883784 )
2013

Variations for Respiratory Distress Syndrome, Infant

ClinVar genetic disease variations for Respiratory Distress Syndrome, Infant:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806

Expression for Respiratory Distress Syndrome, Infant

Search GEO for disease gene expression data for Respiratory Distress Syndrome, Infant.

Pathways for Respiratory Distress Syndrome, Infant

GO Terms for Respiratory Distress Syndrome, Infant

Sources for Respiratory Distress Syndrome, Infant

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....