IRDS
MCID: RSP007
MIFTS: 22

Respiratory Distress Syndrome, Infant (IRDS) malady

Categories: Rare diseases

Aliases & Classifications for Respiratory Distress Syndrome, Infant

Aliases & Descriptions for Respiratory Distress Syndrome, Infant:

Name: Respiratory Distress Syndrome, Infant 50
Hyaline Membrane Disease 50 69
Rds - Infants 50 69
Infantile Respiratory Distress Syndrome 50
Neonatal Respiratory Distress Syndrome 50
Respiratory Distress Syndrome, Newborn 69
Irds 50
Nrds 50

Classifications:



Summaries for Respiratory Distress Syndrome, Infant

MalaCards based summary : Respiratory Distress Syndrome, Infant, also known as hyaline membrane disease, is related to choreoathetosis, hypothyroidism, and neonatal respiratory distress and peroxisome biogenesis disorder 1b, and has symptoms including cheyne-stokes respiration, coughing and dyspnea. The drugs Infasurf and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include lung.

Related Diseases for Respiratory Distress Syndrome, Infant

Graphical network of the top 20 diseases related to Respiratory Distress Syndrome, Infant:



Diseases related to Respiratory Distress Syndrome, Infant

Symptoms & Phenotypes for Respiratory Distress Syndrome, Infant

UMLS symptoms related to Respiratory Distress Syndrome, Infant:


cheyne-stokes respiration, coughing, dyspnea, hemoptysis, hoarseness, respiratory distress

Drugs & Therapeutics for Respiratory Distress Syndrome, Infant

FDA approved drugs:

id Drug Name Active Ingredient(s) 17 Company Approval Date
1
Infasurf 17 CALFACTANT ONY Approved July 1998

Drugs for Respiratory Distress Syndrome, Infant (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 382)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4 4205-90-7 2803
2
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
3
Midazolam Approved, Illicit Phase 4,Phase 3 59467-70-8 4192
4
Acetaminophen Approved Phase 4,Phase 2,Phase 3,Phase 1 103-90-2 1983
5
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
6
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
7
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-23-7 5754 657311
8
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2 378-44-9 9782
9
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
10
Budesonide Approved Phase 4,Phase 2 51333-22-3 63006 5281004
11
Remifentanil Approved Phase 4 132875-61-7 60815
12
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3 2078-54-8 4943
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
14
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
15
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
16
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
17
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
18
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
19 Beractant Approved Phase 4,Phase 2,Phase 3,Phase 1 108778-82-1
20
Povidone-iodine Approved Phase 4,Phase 3,Phase 2 25655-41-8
21 Poractant alfa Approved Phase 4,Phase 2,Phase 3 129069-19-8
22
Carbon monoxide Approved Phase 4,Phase 1 630-08-0 281
23
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 50-02-2 5743
24
Progesterone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 57-83-0 5994
25
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3 57-27-2 5288826
26
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
27
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
28
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
30
Misoprostol Approved Phase 4 59122-46-2 5282381
31 tannic acid Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1
32
Glycine Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 56-40-6 750
33
Butyric Acid Experimental Phase 4,Phase 3,Phase 2 107-92-6 264
34 Cisatracurium Phase 4,Phase 3
35 Prednisolone acetate Phase 4,Phase 2,Phase 3
36 Betamethasone Valerate Phase 4,Phase 3,Phase 2 2152-44-5
37 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
38 glucocorticoids Phase 4,Phase 2,Phase 3
39
protease inhibitors Phase 4,Phase 2,Phase 3,Phase 1
40 Serine Proteinase Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
41 Adjuvants, Anesthesia Phase 4,Phase 3
42 Narcotics Phase 4
43 GABA Agents Phase 4,Phase 3
44 GABA Modulators Phase 4,Phase 3
45 Nefopam Phase 4
46 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
47 Neuromuscular Agents Phase 4,Phase 1,Phase 2
48 Neuromuscular Blocking Agents Phase 4,Phase 3,Phase 1,Phase 2
49 Neuroprotective Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 932)
id Name Status NCT ID Phase
1 Propofol Versus Midazolam as Premedication for Preterm Neonates With Respiratory Distress Syndrome (RDS) Unknown status NCT00797160 Phase 4
2 Efficacy Evaluation of Surfactant Administration Via Laryngeal Mask Airway Unknown status NCT01173237 Phase 4
3 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
4 Effects of Neuromuscular Blocking Agents (NMBA) on the Alteration of Transpulmonary Pressures at the Early Phase of Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT01573715 Phase 4
5 Effect of Treatment With Stress-Doses Glucocorticoid in Patients With Acute Respiratory Distress Syndrome (ARDS) Unknown status NCT00773058 Phase 4
6 Two Strategies of RDS Treatment in Newborns With Birth Weight > 1500 Grams Unknown status NCT00277030 Phase 4
7 Prevention of Chronic Lung Disease (CLD) in Preterm Infants Unknown status NCT00883532 Phase 4
8 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4
9 Surfactant Administration During Spontaneous Breathing Unknown status NCT01329432 Phase 4
10 The Study of Using Esophageal Pressure to Guide the PEEP Setting in Abdominal Hypertension Patients Who Undergoing Mechanical Ventilation Unknown status NCT01825304 Phase 4
11 6-Methyl-Prednisolone for Multiple Organ Dysfunction Syndrome Unknown status NCT00127985 Phase 4
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
14 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
15 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
16 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
17 Effects of Bolus Surfactant Therapy on Peripheral Perfusion Index and Tissue Carbon Monoxide Completed NCT01923844 Phase 4
18 Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome Completed NCT00391105 Phase 4
19 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
20 Diffuse Acute Respiratory Distress Syndrome (ARDS), Recruitment Maneuver, and sRAGE (DAMAGE Study) Completed NCT01600651 Phase 4
21 Randomized Controlled Trial of Surfactant Delivery Via Laryngeal Mask Airway (LMA) Versus Endotracheal Intubation Completed NCT01042600 Phase 4
22 Effects of SEvoflurane on Gas Exchange and Inflammation in Patients With ARDS (SEGA Study) Completed NCT02166853 Phase 4
23 Efficacy of Combining Prophylactic Curosurf With Early Nasal CPAP in Delivery Room: the Curpap Study Completed NCT00501982 Phase 4
24 Caesarean and Corticotherapy Completed NCT00446953 Phase 4
25 Synchronized Intermittent Mandatory Ventilation (SIMV) Versus Nasal Intermittent Positive Pressure Ventilation (NIPPV) In Preterm Infants With Respiratory Distress Completed NCT00486850 Phase 4
26 Comparison of Effectiveness of Nasal CPAP and Nasal IMV in Early Rescue Surfactant Treatment in Preterm Infants Completed NCT01741129 Phase 4
27 Premedication for Non-Emergency Endotracheal Intubation In the NICU Completed NCT01749501 Phase 4
28 INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery Completed NCT01020409 Phase 4
29 Effect of Perioperative Lung Protective Strategies on the Occurrence of Postoperative Pulmonary Complications in Patients Undergoing Lumbar Spinal Surgery in the Prone Position Completed NCT02373475 Phase 4
30 Steroids in Bilateral Total Knee Replacement Completed NCT01399268 Phase 4
31 Vaginal Progesterone for Prevention of Preterm Labor in Asymptomatic Twin Pregnancies With Sonographic Short Cervix Completed NCT02338830 Phase 4
32 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
33 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part IV Completed NCT01604447 Phase 4
34 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
35 Evaluate the Use of Plastic Bags in Preventing and Treating Hypothermia in Neonates Completed NCT01403623 Phase 4
36 Efficacy of 17 Alpha-hydroxyprogesterones Caproate for the Prevention of Preterm Delivery Completed NCT00331695 Phase 4
37 Intraoperative Protective Ventilation in Abdominal Surgery (IMPROVE Study) Completed NCT01282996 Phase 4
38 Study of Sivelestat Sodium Hydrate in Acute Lung Injury (ALI) Associated With Systemic Inflammatory Response Syndrome (SIRS) in Japan Completed NCT00219375 Phase 4
39 Corticosteroid Mediates Acute Respiratory Distress Syndrome Recruiting NCT02819453 Phase 4
40 Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome Recruiting NCT01731795 Phase 4
41 Surfactant Via Endotracheal Tube vs. Laryngeal Mask Airway (LMA) in Preterm Neonates With Respiratory Distress Syndrome Recruiting NCT02164734 Phase 4
42 Impact of Fluid Resuscitation Therapy on Pulmonary Edema as Measured by Alveolar Fluid Clearance in Patients With Acute Respiratory Distress Syndrome (ARDS) Recruiting NCT01763853 Phase 4
43 Effect of Antenatal Steroid on Pulmonary Artery Blood Flow Recruiting NCT02978976 Phase 4
44 Vaginal Progesterone Versus Cervical Cerclage for Pregnant Women With Short Cervix and History of PTL and/or MTM Recruiting NCT02673359 Phase 4
45 Dexmedetomidine Versus Standard Clinical Practice During Non Invasive Mechanical Ventilation Recruiting NCT02958150 Phase 4
46 Early Non-invasive Ventilation Outside the Intensive Care Unit Recruiting NCT01572337 Phase 4
47 Preventing Cardiovascular collaPse With Administration of Fluid Resuscitation Before Endotracheal Intubation Recruiting NCT03026777 Phase 4
48 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part II Recruiting NCT01604421 Phase 4
49 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I Recruiting NCT01604317 Phase 4
50 Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III Recruiting NCT01604434 Phase 4

Search NIH Clinical Center for Respiratory Distress Syndrome, Infant

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Respiratory Distress Syndrome, Infant

Anatomical Context for Respiratory Distress Syndrome, Infant

MalaCards organs/tissues related to Respiratory Distress Syndrome, Infant:

39
Lung

Publications for Respiratory Distress Syndrome, Infant

Articles related to Respiratory Distress Syndrome, Infant:

id Title Authors Year
1
Clinical and biological role of secretory phospholipase A2 in acute respiratory distress syndrome infants. ( 23883784 )
2013

Variations for Respiratory Distress Syndrome, Infant

ClinVar genetic disease variations for Respiratory Distress Syndrome, Infant:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BRAF NM_004333.4(BRAF): c.1502A> G (p.Glu501Gly) single nucleotide variant Pathogenic/Likely pathogenic rs180177039 GRCh37 Chromosome 7, 140477806: 140477806

Expression for Respiratory Distress Syndrome, Infant

Search GEO for disease gene expression data for Respiratory Distress Syndrome, Infant.

Pathways for Respiratory Distress Syndrome, Infant

GO Terms for Respiratory Distress Syndrome, Infant

Sources for Respiratory Distress Syndrome, Infant

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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