MCID: RSP003
MIFTS: 68

Respiratory Failure

Categories: Respiratory diseases, Fetal diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Respiratory Failure

MalaCards integrated aliases for Respiratory Failure:

Name: Respiratory Failure 12 29 52 41 14 69
Chronic Respiratory Failure 12 52 69
Acute Respiratory Failure 12 52 69
Acute-on-Chronic Respiratory Failure 12 69
Respiratory Insufficiency 29 69
Acute and Chronic Respiratory Failure 12
Chronic Disease of Respiratory System 69
Respiratory Insufficiency/failure 12
Pulmonary Valve Insufficiency 69
Chronic Respiratory Disease 52
Respiratory Tract Diseases 69
Respiration Disorders 69
Respiratory Disease 52

Classifications:



External Ids:

Disease Ontology 12 DOID:11162
ICD9CM 35 518.81
NCIt 47 C27043
SNOMED-CT 64 65710008
UMLS 69 C0264490

Summaries for Respiratory Failure

MedlinePlus : 41 respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards based summary : Respiratory Failure, also known as chronic respiratory failure, is related to muscular dystrophy, rigid spine, 1 and burns, and has symptoms including anoxemia, pleuritic pain and cheyne-stokes respiration. An important gene associated with Respiratory Failure is SFTPB (Surfactant Protein B), and among its related pathways/superpathways are Diseases of metabolism and FOXA2 and FOXA3 transcription factor networks. The drugs Riluzole and Beractant have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and testes, and related phenotypes are homeostasis/metabolism and behavior/neurological

Disease Ontology : 12 A lung disease characterized by inadequate gas exchange by the respiratory system.

CDC : 3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and “gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia : 72 Respiratory failure results from inadequate gas exchange by the respiratory system, meaning that the... more...

Related Diseases for Respiratory Failure

Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 460)
id Related Disease Score Top Affiliating Genes
1 muscular dystrophy, rigid spine, 1 31.3 GAA LAMA2 TTN
2 burns 30.1 ELANE SCGB1A1 SFTPB
3 exocrine pancreatic insufficiency 29.9 ALB CRP TNF
4 pulmonary embolism 29.8 ALB CRP TNF
5 clear cell sarcoma 28.1 GAA LAMA2 PIK3C2A TK2 TTN
6 acute chest syndrome 27.7 ALB CRP ELANE PDE4A SFTPC SFTPD
7 neonatal respiratory failure 12.2
8 hereditary proximal myopathy with early respiratory failure 12.0
9 congenital muscular dystrophy-respiratory failure-skin abnormalities-joint hyperlaxity syndrome 11.9
10 myopathy, distal, with early respiratory failure, autosomal dominant 11.9
11 myopathy, proximal, with early respiratory muscle involvement 11.7
12 neuronopathy, distal hereditary motor, type vi 11.7
13 idiopathic acute eosinophilic pneumonia 11.0
14 status asthmaticus 11.0
15 lung disease 10.9
16 midface dysplasia 10.9 ALB TTR
17 pulmonary edema 10.9
18 thyrotoxic periodic paralysis 10.9
19 asthma, aspirin-induced 10.9
20 spinal muscular atrophy with respiratory distress type 2 10.9
21 combined oxidative phosphorylation deficiency 3 10.9
22 adult respiratory distress syndrome 10.9
23 perry syndrome 10.9
24 myofibrillar myopathy 10.9
25 guillain-barre syndrome 10.9
26 trichinosis 10.9
27 paroxysmal cold hemoglobinuria 10.9 SCGB1A1 SFTPB
28 congenital dyserythropoietic anemia 10.9 ALB TNF
29 early-onset severe reducing body myopathy, x-linked 10.8 ALB TTR
30 anonychia with flexural pigmentation 10.8 SFTPB SFTPC
31 opsismodysplasia 10.8
32 nemaline myopathy 8, autosomal recessive 10.8
33 pediculus humanus corporis infestation 10.8 SCGB1A1 SFTPB
34 esophagus adenocarcinoma 10.7 NKX2-1 SFTPB
35 toxic shock syndrome 10.7 ELANE SLC4A1
36 cataract 10.7 ALB TNF TTR
37 speech and communication disorders 10.7 ALB CRP TTR
38 milker's nodule 10.7 ALB CRP TTR
39 multiple mitochondrial dysfunctions syndrome 1 10.7
40 trifunctional protein deficiency 10.7
41 pulmonary alveolar microlithiasis 10.7
42 nemaline myopathy 11, autosomal recessive 10.7
43 amyotrophic lateral sclerosis 21 10.7
44 mitochondrial dna depletion syndrome 2 10.7
45 panbronchiolitis, diffuse 10.7
46 miller fisher syndrome 10.7
47 acute interstitial pneumonia 10.7
48 hemolytic anemia due to triosephosphate isomerase deficiency 10.7
49 amyotrophic lateral sclerosis 1 10.7
50 nemaline myopathy 10 10.7

Comorbidity relations with Respiratory Failure via Phenotypic Disease Network (PDN): (show top 50) (show all 119)


Acquired Polycythemia Acquired Thrombocytopenia
Active Peptic Ulcer Disease Acute Cor Pulmonale
Acute Cystitis Acute Kidney Failure
Acute Myocardial Infarction Acute Pancreatitis
Alcohol Abuse Alcoholic Cardiomyopathy
Alcoholic Liver Cirrhosis Amyotrophic Lateral Sclerosis 1
Anthracosis Anxiety Disorder
Aortic Aneurysm Asbestosis
Aspergillosis Asthma Susceptibility, Phf11-Related
Bleeding Disorder, Platelet-Type, 11 Bronchiectasis
Bronchitis Bronchopneumonia
Candidiasis Cardiac Arrest
Cardiogenic Shock Cardiomyopathy, Familial Hypertrophic
Chronic Kidney Failure Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Conjunctivitis
Decubitus Ulcer Deficiency Anemia
Dermatomycosis Diabetic Polyneuropathy
Diaphragm Disease Disseminated Intravascular Coagulation
Dysthymic Disorder Encephalopathy
Esophageal Candidiasis Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Goodpasture Syndrome Heart Conduction Disease
Heart Disease Hepatic Encephalopathy
Hypertension, Essential Hypertensive Encephalopathy
Hyperuricemia, Pulmonary Hypertension, Renal Failure, and Alkalosis Hypoglycemia

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to Respiratory Failure

Symptoms & Phenotypes for Respiratory Failure

UMLS symptoms related to Respiratory Failure:


anoxemia, pleuritic pain, cheyne-stokes respiration, coughing, cyanosis, dyspnea, edema, hemoptysis, hoarseness, stridor, wheezing, sinus congestion, other symptoms involving respiratory system and chest, signs and symptoms of ill-defined conditions, inspiratory wheeze, expiratory wheeze, bronchorrhea, neonatal cyanosis, gasping for breath, symptoms involving respiratory system and other chest symptoms, respiratory distress, choking sensation, labored breathing, inspiratory stridor, nasal congestion (finding), pathological conditions, signs and symptoms, nasal irritation, sore throat, neck tightness, larynx pain, rhinorrhea, snoring

MGI Mouse Phenotypes related to Respiratory Failure:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.28 IGHMBP2 LAMA2 NKX2-1 PIK3C2A SCGB1A1 SFTPB
2 behavior/neurological MP:0005386 10.23 SFTPC TK2 TNF TTN ALPL DCTN1
3 cardiovascular system MP:0005385 10.21 ALPL CRP GAA IGHMBP2 NKX2-1 PDE4A
4 cellular MP:0005384 10.18 ALB ALPL DCTN1 GAA IGHMBP2 LAMA2
5 growth/size/body region MP:0005378 10.18 ALPL GAA IGHMBP2 LAMA2 NKX2-1 PIK3C2A
6 mortality/aging MP:0010768 10.06 ALB ALPL DCTN1 ELANE IGHMBP2 LAMA2
7 immune system MP:0005387 10.03 TNF TTN ALPL CRP ELANE LAMA2
8 muscle MP:0005369 9.61 ALPL GAA IGHMBP2 LAMA2 SLC4A1 TK2
9 respiratory system MP:0005388 9.23 ALPL IGHMBP2 NKX2-1 SCGB1A1 SFTPB SFTPC

Drugs & Therapeutics for Respiratory Failure

Drugs for Respiratory Failure (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 510)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Riluzole Approved, Investigational Phase 4,Phase 2,Phase 3 1744-22-5 5070
2 Beractant Approved Phase 4,Phase 3 108778-82-1
3 Poractant alfa Approved Phase 4,Phase 2 129069-19-8
4
Zinc Approved Phase 4,Phase 3,Phase 2 7440-66-6 32051 23994
5
Acetaminophen Approved Phase 4,Phase 3,Early Phase 1 103-90-2 1983
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Ropivacaine Approved Phase 4,Early Phase 1 84057-95-4 71273 175805
8
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
10
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
11
Dexlansoprazole Approved Phase 4 138530-94-6, 103577-45-3 9578005
12
Lansoprazole Approved, Investigational Phase 4 103577-45-3 3883
13
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
14
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
15
Ketamine Approved, Vet_approved Phase 4,Phase 3 6740-88-1 3821
16
Nitrous oxide Approved, Vet_approved Phase 4,Phase 2,Phase 3 10024-97-2 948
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 2078-54-8 4943
18
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
19
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 83-43-2 6741
20
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-24-8 5755
21
Diclofenac Approved, Vet_approved Phase 4,Early Phase 1 15307-86-5 3033
22
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
23
Morphine Approved, Investigational Phase 4,Phase 2 57-27-2 5288826
24
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 76631-46-4, 113775-47-6 68602 5311068 56032
25
Menthol Approved Phase 4,Phase 1 2216-51-5 16666
26
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
27
Furosemide Approved, Vet_approved Phase 4,Phase 3 54-31-9 3440
28
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
29
Adenosine Approved, Investigational Phase 4 58-61-7 60961
30
Remifentanil Approved Phase 4,Phase 1 132875-61-7 60815
31
Sevoflurane Approved, Vet_approved Phase 4,Phase 3 28523-86-6 5206
32
Procaterol Approved Phase 4 72332-33-3 688561
33
Ticlopidine Approved Phase 4 55142-85-3 5472
34
Diltiazem Approved Phase 4 42399-41-7 39186
35
Metoprolol Approved, Investigational Phase 4,Phase 3 37350-58-6, 51384-51-1 4171
36
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
37
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456
38
Citalopram Approved Phase 4 59729-33-8 2771
39
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 437-38-7 3345
40
Nalbuphine Approved Phase 4 20594-83-6 5360630 5311304
41
Orphenadrine Approved Phase 4 83-98-7 4601
42
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2 137-58-6 3676
43
Ipratropium Approved Phase 4 22254-24-6, 60205-81-4 43232
44
Carvedilol Approved, Investigational Phase 4 72956-09-3 2585
45
Nebivolol Approved, Investigational Phase 4 152520-56-4, 99200-09-6, 118457-14-0 71301
46
Ephedrine Approved Phase 4 299-42-3 9294
47
Oxymetazoline Approved Phase 4,Phase 2 1491-59-4 4636
48
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
49
Pseudoephedrine Approved Phase 4 90-82-4 7028
50
Cetirizine Approved Phase 4,Phase 3 83881-51-0 2678

Interventional clinical trials:

(show top 50) (show all 1384)

id Name Status NCT ID Phase Drugs
1 Neurally Adjusted Ventilatory Assist (NAVA) vs. Pressure Support in Pediatric Acute Respiratory Failure Unknown status NCT01873521 Phase 4
2 FRC Guided Therapy in Acute Respiratory Failure Unknown status NCT01280019 Phase 4
3 Comparative Study of Non-Invasive Mask Ventilation vs Cuirass Ventilation in Patients With Acute Respiratory Failure. Unknown status NCT00331656 Phase 4
4 Comparison of Pressure Support and Pressure Control Ventilation in Chronic Respiratory Failure Unknown status NCT00994552 Phase 4
5 Inspiratory Muscle Training in Hypercapnic COPD Unknown status NCT00291460 Phase 4
6 Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis Unknown status NCT00560287 Phase 4
7 Brain Oxygenation and Function of Preterm Newborns During Administration of Two Different Surfactant Preparations Unknown status NCT01941524 Phase 4 Poractant alfa instillation;Beractant instillation
8 Immunonutrition and Thoracoabdominal Aorta Aneurysm Repair Unknown status NCT00339053 Phase 4 Immunonutrition ( Impact)
9 Physiological Response to Heliox21 and Air O2 Unknown status NCT01498432 Phase 4 Heliox21;Air O2
10 A Trial Comparing SGC and Conventional Empiric Treatment for Glucose Control in Critically Ill Patients With Mechanical Ventilation in ICU Unknown status NCT02491346 Phase 4
11 Comparison of Nasal CPAP and Nasal SIMV in Transient Tachypnea of Newborn Unknown status NCT01499238 Phase 4
12 Epidural Analgesia for Pancreatitis (Epipan Study) Unknown status NCT02126332 Phase 4
13 Renal Effects of Levosimendan in Patients Admitted With Acute Decompensated Heart Failure Unknown status NCT00527059 Phase 4 Levosimendan in addition to standard therapy;spironolactone, beta-blockers,ecc
14 The Relationship Between Gastroesophageal Reflux and Pediatric Rhinitis: Significance of Pale/Blue Colored Turbinate Unknown status NCT02278081 Phase 4 lansoprazole;placebo
15 Inspiratory Muscle Training in Patients With End Stage Renal Failure Unknown status NCT01347775 Phase 4
16 Clinical Trial Assessing Two Protocols to Withdraw Non-invasive Ventilation in Hypercapnic Respiratory Failure Completed NCT00775710 Phase 4
17 Acetazolamide for Respiratory Failure in Combination With Metabolic Alkalosis Completed NCT00222534 Phase 4 Acetazolamide;Placebo
18 Helmet Ventilation in Acute Hypercapnic Respiratory Failure Completed NCT01645358 Phase 4
19 Evaluation Of The Total Face Mask For Emergency Application In Acute Respiratory Failure Completed NCT00686257 Phase 4
20 Ambulatory Adaptation to Non-Invasive Mechanical Ventilation Completed NCT00698958 Phase 4
21 B-type Natriuretic Peptide (BNP)-Guided Diagnostic Strategy in Intensive Care Unit (ICU) Patients With Respiratory Failure Completed NCT00130559 Phase 4
22 Brain Natriuretic Peptide (BNP) Levels in Patients in Non Invasive Mechanical Ventilation Completed NCT00453726 Phase 4
23 Non-invasive Ventilation in Terminally Ill Cancer Patients Completed NCT00533143 Phase 4
24 Patients-ventilator Interaction During Sleep: Effect of Humidification System Completed NCT01038791 Phase 4
25 Non-Positive Pressure Ventilation in Hypoxemic Patients Completed NCT00925860 Phase 4
26 Inhaled Nitric Oxide by Oxygen Hood in Neonates Completed NCT00732537 Phase 4 inhaled Nitric Oxide;Oxygen (>90% by hood) - standard therapy
27 Early Application of CPAP in Hematologic Completed NCT00507533 Phase 4
28 Proportional Assist Ventilation (PAV) in Early Stage of Critically Ill Patients Completed NCT01204281 Phase 4
29 Comparison of the Efficacy for Stress Ulcer Prophylaxis Between the Patients Received Lansoprazole OD and Control Group Weaning From Mechanical Ventilator in Respiratory Care Center: a Randomized Control Trial Completed NCT00708149 Phase 4 lansoprazole OD;placebo
30 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients Completed NCT00355732 Phase 4
31 Prevention of Pressure Ulcers in Patients Under Non-Invasive Mechanical Ventilation Completed NCT02526862 Phase 4
32 Checklists and Upright Positioning in Endotracheal Intubation of Critically Ill Patients (Check-UP) Trial Completed NCT02497729 Phase 4
33 Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients Completed NCT01472302 Phase 4
34 Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics Completed NCT02363920 Phase 4
35 Effect of Non-invasive Ventilation (NIV) on Cerebral Oxygenation Completed NCT02454582 Phase 4
36 Standard Treatment Compliance of Participants, Effectiveness and Prognosis in Acute Respiratory Distress Syndrome Completed NCT02178982 Phase 4
37 Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency Completed NCT01350297 Phase 4
38 Effects of Remifentanil on Respiratory Function in Mechanically Ventilated Patients Completed NCT00665119 Phase 4 remifentanil;placebo
39 Anesthesia for Retinopathy of Prematurity Completed NCT01955135 Phase 4 Ketamine;Sevoflurane;propofol
40 Supplemental Oxygen and Complications After Abdominal Surgery (The PROXI-trial) Completed NCT00364741 Phase 4 Oxygen
41 Non Invasive Mechanical Ventilation Versus Respiratory Rehabilitation in Hypercapnic COPD Completed NCT01377818 Phase 4
42 Comparative Study on the Efficacy and Safety of Procaterol Versus Salbutamol Given Via Metered Dose Inhaler With Spacer in the Management of Acute Asthma Attack in the Emergency Room Completed NCT01091337 Phase 4 Procaterol;Salbutamol
43 Effect of Clopidogrel (Plavix) on Postoperative Bleeding in Patients Undergoing Coronary Artery Bypass Surgery. Completed NCT00724880 Phase 4 Clopidogrel;Clopidogrel;Clopidogrel
44 Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome Completed NCT02041546 Phase 4 Lung lavage with surfactant;Bolus surfactant
45 Glucocorticoid Therapy Impact on the Inflammatory Response and Clinical Evolution in Patients With Severe Bronchiolitis Completed NCT02571517 Phase 4 Glucocorticoids
46 Botulism Outbreak in Thailand (Episode II) Completed NCT00348426 Phase 4 Botulinum AntiToxin
47 Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter Completed NCT01914926 Phase 4 Metoprolol;Diltiazem
48 Follow-Up at 6 Years of a Cohort of Children Born Very Prematurely Completed NCT00390065 Phase 4 Nitric Oxide
49 Effect of Neuromuscular Reversal With Sugammadex on Postoperative Recovery Profile Completed NCT02243943 Phase 4 Sugammadex;Neostigmine
50 Preventing Depression in People Receiving Mechanical Ventilation in an Intensive Care Unit Completed NCT00872027 Phase 4 Escitalopram;Placebo

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Respiratory Failure

Genetic tests related to Respiratory Failure:

id Genetic test Affiliating Genes
1 Respiratory Failure 29
2 Respiratory Insufficiency 29

Anatomical Context for Respiratory Failure

MalaCards organs/tissues related to Respiratory Failure:

39
Lung, Heart, Testes, Brain, Spinal Cord, Kidney, Liver

Publications for Respiratory Failure

Articles related to Respiratory Failure:

(show top 50) (show all 1164)
id Title Authors Year
1
A 53-year-old man with dyspnoea, respiratory failure, consistent with infliximab-induced acute interstitial pneumonitis after an accelerated induction dosing schedule. ( 28500116 )
2017
2
Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: Yes. ( 28074228 )
2017
3
Early vertebroplasty associated with a lower risk of mortality and respiratory failure in aged patients with painful vertebral compression fractures: a population-based cohort study in Taiwan. ( 28483705 )
2017
4
Extracorporeal Life Support for severe respiratory failure with special reference to the influenza H1N1 pandemic. ( 28066903 )
2017
5
Effect of inhaled nitric oxide on oxygen therapy, mechanical ventilation, and hypoxic respiratory failure. ( 28472876 )
2017
6
Mechanical ventilatory modes and cardioventilatory phase synchronization in acute respiratory failure patients. ( 28052047 )
2017
7
Impact of a Noninvasive Ventilation Protocol in Hospitalized Children With Acute Respiratory Failure. ( 28951468 )
2017
8
Volume-Targeted Versus Pressure-Limited in Noninvasive Ventilation in Hypercapnic Respiratory Failure. What Could Be Established in Real Practice?-Reply. ( 28924027 )
2017
9
A prospective cohort study of thoracic ultrasound in acute respiratory failure: the C3PO protocol. ( 28515954 )
2017
10
Early decrease of oxidative stress by non-invasive ventilation in patients with acute respiratory failure. ( 28914417 )
2017
11
Rare Cause of Type 2 Respiratory Failure: Arnold Chiari Malformation. ( 28527177 )
2017
12
Refractory acute respiratory failure due to Pneumocystis jiroveci (PCP) and Cytomegalovirus (CMV) pneumonitis: A case report and review of literature. ( 28879093 )
2017
13
Influenza vaccination and risk of respiratory failure in patients with chronic obstructive pulmonary disease: A nationwide population-based case-cohort study. ( 28927683 )
2017
14
A 62-Year-Old Woman With Wheezing, Respiratory Failure, and an Abnormal CTA Scan. ( 28889900 )
2017
15
Author response: Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia. ( 28847836 )
2017
16
Acute Respiratory Failure as the First Manifestation of Antisynthetase Syndrome. ( 28638428 )
2017
17
Association Between Antipsychotic Agents and Risk of Acute Respiratory Failure in Patients With Chronic Obstructive Pulmonary Disease. ( 28055066 )
2017
18
Respiratory Failure due to Severe Obesity and Kyphoscoliosis in a 24-Year-Old Male with Molecularly Confirmed Prader-Willi Syndrome in Tertiary Hospital in Northern Tanzania. ( 28487784 )
2017
19
Circulating chromogranin B levels in patients with acute respiratory failure: data from the FINNALI Study. ( 28049363 )
2017
20
Nitric oxide for respiratory failure in infants born at or near term. ( 28056166 )
2017
21
Mortality and Respiratory Failure After Thoracoscopic Lung Biopsy for Interstitial Lung Disease. ( 28527960 )
2017
22
Noninvasive airway approaches for acute neuromuscular respiratory failure in emergency departments. ( 28941227 )
2017
23
The Challenges of Identifying an Oxygenation Index Threshold for Increased Mortality in Pediatric Acute Respiratory Failure. ( 28924025 )
2017
24
Lung Rest During Extracorporeal Membrane Oxygenation for Neonatal Respiratory Failure-Practice Variations and Outcomes. ( 28504997 )
2017
25
Propofol as a Risk Factor for ICU-Acquired Weakness in Septic Patients with Acute Respiratory Failure. ( 28091345 )
2017
26
Does permissive hypoxaemia during extracorporeal membrane oxygenation cause long-term neurological impairment?: A study in patients with H1N1-induced severe respiratory failure. ( 28030441 )
2017
27
Acute amiodarone toxicity causing respiratory failure. ( 28489123 )
2017
28
Letter re: Clinical Reasoning: A young woman with respiratory failure, hearing loss, and paraplegia. ( 28847833 )
2017
29
Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy. ( 28811488 )
2017
30
Does high-flow nasal cannula oxygen improve outcome in acute hypoxemic respiratory failure? A systematic review and meta-analysis. ( 28947043 )
2017
31
Motor Neuron Disease Presenting With Acute Respiratory Failure: A Case Study. ( 28503469 )
2017
32
Progressive respiratory failure: a rare complication after graded talc pleurodesis. ( 28489449 )
2017
33
Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study. ( 28948369 )
2017
34
Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: We are not sure. ( 28074229 )
2017
35
Slow ventricular tachycardia in a 91-year-old man with implantable cardioverter-defibrillator and acute respiratory failure. ( 28526597 )
2017
36
Inclusion Body Myositis: A Case Presenting with Respiratory Failure and Autopsy Findings Leading to the Hypothesis of a Paraneoplastic Cause. ( 28642454 )
2017
37
Extracorporeal membrane oxygenation in severe influenza infection with respiratory failure: A systematic review and meta-analysis. ( 28074789 )
2017
38
Cosmetic silicone injection causing pneumomediastinum and respiratory failure. ( 28869246 )
2017
39
Efficacy of inhaled nitric oxide in neonates with hypoxic respiratory failure and pulmonary hypertension: the Japanese experience. ( 28926340 )
2017
40
The most frequent ABCA3 nonsense mutation -p.Tyr1515* (Y1515X) causing lethal neonatal respiratory failure in a term neonate. ( 28808495 )
2017
41
Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells. ( 28873200 )
2017
42
Anaemia and respiratory failure in a child: can it be idiopathic pulmonary haemosiderosis? ( 28512100 )
2017
43
Beneficial Effects of Noninvasive Ventilation in Acute Hypoxemic Respiratory Failure: Caution With Findings From Meta-Analyses. ( 28915197 )
2017
44
A Prospective One-Year Microbiologic Survey of Combined Pneumonia and Respiratory Failure. ( 28880805 )
2017
45
Ventilation-induced lung injury exists in spontaneously breathing patients with acute respiratory failure: No. ( 28074230 )
2017
46
The efficacy of initial ventilation strategy for adult immunocompromised patients with severe acute hypoxemic respiratory failure: study protocol for a multicentre randomized controlled trial (VENIM). ( 28931394 )
2017
47
Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation? A systematic review and meta-analysis. ( 28089816 )
2017
48
Management Strategies for Severe Respiratory Failure: As Extracorporeal Membrane Oxygenation Is Being Considered. ( 28887928 )
2017
49
Neonatal Respiratory Failure Caused by Congenital Diffuse Intrinsic Pontine Glioma. ( 28116951 )
2017
50
Non-invasive ventilation during cycle exercise training in patients with chronic respiratory failure on long-term ventilatory support: A randomized controlled trial. ( 28940820 )
2017

Variations for Respiratory Failure

ClinVar genetic disease variations for Respiratory Failure:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 MUSK NM_005592.3(MUSK): c.1724T> C (p.Ile575Thr) single nucleotide variant Pathogenic/Likely pathogenic rs751889864 GRCh38 Chromosome 9, 110785664: 110785664

Expression for Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

GO Terms for Respiratory Failure

Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALB ALPL CRP ELANE LAMA2 SCGB1A1
2 clathrin-coated endocytic vesicle GO:0045334 9.43 SFTPB SFTPC SFTPD
3 multivesicular body lumen GO:0097486 9.37 SFTPB SFTPC
4 extracellular space GO:0005615 9.36 ALB ALPL CRP ELANE LAMA2 SCGB1A1
5 lamellar body GO:0042599 9.33 SFTPB SFTPC SFTPD
6 extracellular exosome GO:0070062 10.06 ALB ALPL CRP ELANE GAA LAMA2

Biological processes related to Respiratory Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 9.5 ALPL SCGB1A1 TNF
2 negative regulation of growth of symbiont in host GO:0044130 9.37 ELANE TNF
3 negative regulation of lipid storage GO:0010888 9.26 CRP TNF
4 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.16 ELANE TNF
5 respiratory gaseous exchange GO:0007585 9.13 SFTPB SFTPC SFTPD
6 cellular protein metabolic process GO:0044267 9.02 ALB SFTPB SFTPC SFTPD TTR

Molecular functions related to Respiratory Failure according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 ELANE TNF TTN

Sources for Respiratory Failure

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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