MCID: RSP003
MIFTS: 68

Respiratory Failure malady

Respiratory diseases, Fetal diseases, Rare diseases, Infectious diseases categories
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Summaries for Respiratory Failure

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34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards: Respiratory Failure, also known as chronic respiratory failure, is related to pneumonia and neuromuscular disease. An important gene associated with Respiratory Failure is SFTPB (surfactant protein B), and among its related pathways are FOXA1 transcription factor network and Selected targets of C EBPalpha. The drugs naloxone and nalmefene and the compounds infasurf and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are muscle and tumorigenesis.

CDC:4 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:65 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Aliases & Classifications for Respiratory Failure

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

respiratory failure 8 10 45 34 62
chronic respiratory failure 8 45 62
acute respiratory failure 8 45 62
acute-on-chronic respiratory failure 8 62
acute and chronic respiratory failure 8
chronic disease of respiratory system 62
acute on chronic respiratory failure 8
respiratory insufficiency/failure 8
chronic respiratory disease 45
respiratory failure nos 8
respiration disorders 62
respiratory disease 45


External Ids:

Disease Ontology8 DOID:11162
ICD9CM27 518.81
SNOMED-CT58 65710008
NCIt40 C27043

Related Diseases for Respiratory Failure

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 885)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.9SFTPB, SFTPD, SCGB1A1, SFTPC
2neuromuscular disease30.9GAA, TTN
3bronchiolitis30.4APEX1
4rigid spine syndrome30.4GAA
5muscular dystrophy30.3GAA, TTN
6interstitial lung disease30.3SFTPD
7polymyositis30.3SFTPD, TTN, GAA
8bronchopulmonary dysplasia30.3SFTPB, SCGB1A1
9lung cancer30.2SFTPD, SCGB1A1, APEX1, NKX2-1, SFTPB
10pulmonary alveolar proteinosis30.2SFTPB, SFTPD, SFTPC
11limb-girdle muscular dystrophy30.2GAA, TTN
12dermatomyositis30.1SFTPD, GAA
13asthma30.1SFTPD, APEX1, SCGB1A1, SFTPC, SFTPB
14adult respiratory distress syndrome30.1SFTPD, SFTPB, SFTPC
15pulmonary disease, chronic obstructive30.0TTN, SCGB1A1, SFTPD, SFTPB
16congenital diaphragmatic hernia30.0SFTPB
17meconium aspiration syndrome30.0SFTPB, TTN
18newborn respiratory distress syndrome29.9SFTPB, NKX2-1
19spinal muscular atrophy29.9GAA, IGHMBP2
20motor neuron disease29.9IGHMBP2, GAA
21thymoma29.9NKX2-1, TTN
22cystic fibrosis29.9APEX1, SCGB1A1, SFTPC, SFTPD, SFTPB
23idiopathic pulmonary fibrosis29.8SFTPB, SCGB1A1, SFTPD, SFTPC
24lung adenocarcinoma29.7NKX2-1, SCGB1A1, SFTPC, SFTPD, SFTPB
25primary pulmonary hypertension29.6SFTPC, SFTPB
26malignant mesothelioma29.6SFTPB, NKX2-1
27cork-handlers' disease29.6NKX2-1, APEX1, SFTPB, SFTPD, SFTPC, SCGB1A1
28adenocarcinoma29.6SFTPC, SFTPB, NKX2-1, APEX1, SCGB1A1, SFTPD
29neonatal respiratory failure10.8
30hereditary myopathy with early respiratory failure10.6
31myopathy10.5
32status asthmaticus10.5
33influenza10.5
34eosinophilic pneumonia10.4
35botulism10.4
36hypertension10.4
37leukemia10.4
38cor pulmonale10.4
39obstructive lung disease10.3
40tuberculosis10.3
41nemaline myopathy10.3
42hypophosphatemia10.3
43miliary tuberculosis10.3
44lambert-eaton myasthenic syndrome10.3
45cervicitis10.3
46esophagitis10.3
47neuropathy10.3
48polyneuropathy10.3
49rhinotracheitis10.3
50pemphigus10.2

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Symptoms for Respiratory Failure

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Drugs & Therapeutics for Respiratory Failure

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Respiratory Failure

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Respiratory Failure

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Anatomical Context for Respiratory Failure

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33MalaCards
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MalaCards organs/tissues related to Respiratory Failure:

33
Lung, Heart, Brain, Spinal cord, Thyroid, Kidney, Liver, Testes, Skeletal muscle, T cells, Monocytes, Myeloid, Placenta, Skin, Breast, Bone marrow, Bone, Hypothalamus

Animal Models for Respiratory Failure or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Respiratory Failure:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2IGHMBP2, TTN, APEX1, GAA, SLC4A1
2MP:00020068.2NKX2-1, APEX1, SCGB1A1, SFTPC
3MP:00053868.0IGHMBP2, SFTPB, SFTPC, TTN, NKX2-1, GAA
4MP:00053887.7IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, NKX2-1
5MP:00053857.3IGHMBP2, SFTPC, TTN, APEX1, NKX2-1, GAA
6MP:00053877.0SFTPD, SFTPC, SCGB1A1, TTN, APEX1, SLC4A1
7MP:00053766.5IGHMBP2, SFTPB, SFTPD, SCGB1A1, TTN, APEX1
8MP:00053786.3SLC4A1, IGHMBP2, SFTPD, SFTPC, SCGB1A1, TTN
9MP:00107686.3IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, TTN

Publications for Respiratory Failure

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52PubMed
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Articles related to Respiratory Failure:

(show top 50)    (show all 918)
idTitleAuthorsYear
1
Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis. (23578004)
2013
2
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
3
Respiratory failure in a mouse model of myotonic dystrophy does not correlate with the CTG repeat length. (23811192)
2013
4
Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. (24215648)
2013
5
Should high-dose steroid therapy and inhaled nitric oxide be considered for adult patients with H1N1 respiratory failure? (23476736)
2013
6
Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. (23335231)
2013
7
Acute respiratory failure in a rapidly enlarging benign cervical goitre. (23878293)
2013
8
A patient with severe respiratory failure caused by novel human coronavirus. (23900771)
2013
9
Extracorporeal membrane oxygenation as treatment for acute respiratory failure and subsequent pneumothorax caused by Pneumocystis jirovecii pneumonia in a kidney transplant recipient. (23279741)
2013
10
Clinical review: Early treatment of acute lung injury - paradigm shift toward prevention and treatment prior to respiratory failure. (22713281)
2012
11
State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure. (23134246)
2012
12
The pulmonary circulation in neonatal respiratory failure. (22954275)
2012
13
Noninvasive positive pressure ventilation for chronic respiratory failure patients with stable chronic obstructive pulmonary disease (COPD): an evidence-based analysis. (23074437)
2012
14
A middle aged man with respiratory failure and weakness. (22772940)
2012
15
Race and respiratory failure: we need to learn more. (22511158)
2012
16
Single site venovenous extracorporeal membrane oxygenation as an alternative to invasive ventilation in post-pneumonectomy fistula with acute respiratory failure. (22219410)
2012
17
The long duration of extracorporeal membrane oxygenation in a child with acute severe hypoxic respiratory failure treated in a resource-limited center. (22802004)
2012
18
An achondroplasic case with foramen magnum stenosis, hydrocephaly, cortical atrophy, respiratory failure and sympathetic dysfunction. (23056871)
2012
19
Acute respiratory failure from pulmonary tuberculosis due to head trauma immunosupression. (22417046)
2012
20
Acute management of neonatal respiratory failure due to crossed ectopic obstructed megaureter in a duplicated pelvic kidney. (21050823)
2011
21
Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology. (22052861)
2011
22
Noninvasive ventilation for acute respiratory failure in patients with hematologic malignancies: what an Italian 5-year multicenter survey tells us. (21926491)
2011
23
Non-invasive ventilation for surgical patients with acute respiratory failure. (22066065)
2011
24
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect. (21867529)
2011
25
Significance of herpesvirus 6 in BAL fluid of hematology patients with acute respiratory failure. (21538037)
2011
26
Plasma orexin-a levels in COPD patients with hypercapnic respiratory failure. (21765621)
2011
27
A rare cause of acute respiratory failure--allergic bronchopulmonary aspergillosis. (20028466)
2011
28
Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus. (19092662)
2009
29
Adjunctive pharmacotherapy in neonates with respiratory failure. (18851933)
2009
30
Bilateral pulmonary contusion, flail chest and respiratory failure on late iatrogenic diaphragmatic eventration and severe kyphoskoliosis: a case report. (19040741)
2008
31
Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. (19469095)
2008
32
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. (18450855)
2008
33
Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. (17426196)
2007
34
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006
35
Utility of B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in evaluation of respiratory failure in critically ill patients. (16002948)
2005
36
Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients. (12917010)
2004
37
Venovenous extracorporeal membrane oxygenation in neonatal respiratory failure: does routine, cephalad jugular drainage improve outcome? (15136997)
2004
38
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
39
Acute neonatal respiratory failure and Chlamydia trachomatis. (11287694)
2001
40
Opioid peptides attenuate blood pressure increase in acute respiratory failure. (11311734)
2001
41
Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)
1999
42
Intratracheal pulmonary ventilation in neonatal respiratory failure. (9934880)
1999
43
Engraftment syndrome and survival after respiratory failure post-bone marrow transplantation. (9722046)
1998
44
Respiratory failure in nemaline myopathy. (9744641)
1998
45
Respiratory failure following oral administration of metoclopramide. (9793592)
1998
46
Pulmonary alveolar proteinosis with respiratory failure--therapeutic role of bronchoscopic and whole lung lavage. (11229289)
1998
47
Evaluation and treatment of respiratory failure in neuromuscular disease. (9156393)
1997
48
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life. (1609376)
1992
49
Extracorporeal membrane oxygenation in neonatal respiratory failure. A brief overview. (2681581)
1989
50
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (3860734)
1985

Variations for Respiratory Failure

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Expression for genes affiliated with Respiratory Failure

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

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Sources:
50PathCards, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Respiratory Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FOXA transcription factor networks38
9.3SCGB1A1, SFTPD
29.3SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

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Sources:
45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB, 3BitterDB
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Compounds related to Respiratory Failure according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1infasurf4510.1SFTPC, SFTPB
21,2-dipalmitoyl-sn-glycero-3-phosphocholine4510.1SFTPB, SFTPC
3dppg4510.1SFTPB, SFTPC
4popg4510.1SFTPB, SFTPC
5curosurf4510.1SFTPB, SFTPC
62,4-dinitrophenol4510.1NKX2-1, SFTPB
7dopc4510.1SFTPC, SFTPB
8survanta4510.1SFTPC, SFTPB
9dppc4510.1SFTPB, SFTPC
10p-opc4510.0SFTPC, SFTPB
11butanol4510.0SFTPB, SFTPC
12chloroform4510.0SFTPB, SFTPC
13ozone4510.0SFTPB, SCGB1A1
14gold459.9SFTPB, GAA, TTN
15methanol45 2410.9SFTPC, SFTPB
16maltose45 1110.8GAA, SFTPD
17isoleucine459.8SFTPB, SFTPC
18peroxynitrite459.7SLC4A1, SFTPB, SFTPC
19doxycycline45 1110.6SFTPB, SCGB1A1, SFTPC
20mannose459.5GAA, SFTPD, SLC4A1
21ribonucleic acid459.5SFTPC, NKX2-1, SFTPB
22fatty acid459.4GAA, SFTPC, SFTPB
23phosphatidylcholine459.4SFTPB, SFTPD, SFTPC
24hydrogen45 2410.4TTN, SFTPB, SLC4A1, SFTPC
25polyacrylamide459.3SFTPB, TTN, APEX1
26creatinine459.3SCGB1A1, TTN, GAA
27lysine459.3SLC4A1, TTN, SFTPC
28bleomycin45 1110.2SFTPB, SFTPC, APEX1
29anti-fungal459.2SFTPD, APEX1
30potassium45 24 1111.2SLC4A1, APEX1, TTN
31threonine459.2NKX2-1, TTN, SFTPB, SFTPC
32paraffin459.1NKX2-1, SFTPB, APEX1
33leucine459.0SFTPB, SFTPD, SLC4A1, SFTPC
34lactate459.0GAA, SFTPD, SLC4A1
35cholesterol45 29 24 1112.0SLC4A1, SFTPB, SFTPD, SFTPC
36cyclic amp45 249.9SFTPD, SFTPB, SFTPC, NKX2-1
37atp45 299.9SLC4A1, TTN, SFTPB, APEX1
38thymidine45 249.9SFTPB, SFTPD, GAA
39dexamethasone45 51 29 1111.9NKX2-1, SFTPC, SFTPD, SFTPB
40chloramphenicol45 3 51 1111.7SFTPB, SFTPC, SCGB1A1, APEX1
41phospholipid458.6SLC4A1, SFTPB, SFTPD, SFTPC, SCGB1A1
42glucose458.5GAA, SFTPD, APEX1, SLC4A1
43nitric oxide45 24 1110.3SCGB1A1, SFTPD, SFTPB, SLC4A1, APEX1
44serine458.2APEX1, NKX2-1, TTN, SFTPD, SFTPB
45lipid458.2SFTPB, SFTPD, SFTPC, SCGB1A1, GAA, SLC4A1
46oxygen45 249.1SFTPD, SFTPC, SCGB1A1, APEX1, SFTPB
47cysteine458.0TTN, SFTPB, SFTPD, SFTPC, APEX1, SLC4A1
48calcium45 51 24 1110.7SFTPB, SFTPD, APEX1, TTN, SCGB1A1, SFTPC

GO Terms for genes affiliated with Respiratory Failure

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16Gene Ontology
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Cellular components related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057648.9GAA, SFTPD, SFTPB
2extracellular spaceGO:0056158.5SCGB1A1, SFTPC, SFTPD, SFTPB

Biological processes related to Respiratory Failure according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cardiac muscle contractionGO:0600489.8GAA, TTN
2locomotory behaviorGO:0076269.7NKX2-1, GAA
3negative regulation of T cell proliferationGO:0421309.4SCGB1A1, SFTPD
4response to glucocorticoidGO:0513849.3SCGB1A1, SFTPC
5regulation of mRNA stabilityGO:0434889.2SCGB1A1, APEX1
6respiratory gaseous exchangeGO:0075859.2SFTPC, SFTPD, SFTPB
7DNA recombinationGO:0063108.9IGHMBP2, APEX1

Molecular functions related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4SLC4A1, NKX2-1, APEX1, TTN, SCGB1A1, SFTPC

Products for genes affiliated with Respiratory Failure

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  • Antibodies
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Sources for Respiratory Failure

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet