MCID: RSP003
MIFTS: 70

Respiratory Failure malady

Respiratory diseases, Fetal diseases, Rare diseases, Infectious diseases categories
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Summaries for Respiratory Failure

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MedlinePlus:33 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards based summary: Respiratory Failure, also known as chronic respiratory failure, is related to neuromuscular disease and rigid spine syndrome. An important gene associated with Respiratory Failure is SFTPB (surfactant protein B), and among its related pathways are FOXA1 transcription factor network and Selected targets of C EBPalpha. The drugs naloxone and nalmefene and the compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are muscle and tumorigenesis.

CDC:3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:65 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Aliases & Classifications for Respiratory Failure

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Respiratory Failure, Aliases & Descriptions:

Name: Respiratory Failure 8 10 44 33 62
Chronic Respiratory Failure 8 44 62
Acute Respiratory Failure 8 44 62
Acute-on-Chronic Respiratory Failure 8 62
Respiratory Insufficiency/failure 8 62
Acute and Chronic Respiratory Failure 8
 
Chronic Disease of Respiratory System 62
Acute on Chronic Respiratory Failure 8
Chronic Respiratory Disease 44
Respiratory Failure Nos 8
Respiration Disorders 62
Respiratory Disease 44


Classifications:



External Ids:

Disease Ontology8 DOID:11162
ICD9CM27 518.81
SNOMED-CT57 65710008
NCIt39 C27043

Related Diseases for Respiratory Failure

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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 888)
idRelated DiseaseScoreTop Affiliating Genes
1neuromuscular disease31.2GAA, TTN
2rigid spine syndrome30.9GAA
3interstitial lung disease30.8SFTPD
4bronchiolitis30.7APEX1
5pneumonia30.7SFTPB, SFTPD, SCGB1A1, SFTPC
6bronchopulmonary dysplasia30.6SFTPB, SCGB1A1
7pulmonary hypertension30.6SFTPC, SFTPB
8muscular dystrophy30.6GAA, TTN
9limb-girdle muscular dystrophy30.5GAA, TTN
10chronic obstructive pulmonary disease30.5TTN, SCGB1A1, SFTPD, SFTPB
11congenital diaphragmatic hernia30.5SFTPB
12meconium aspiration syndrome30.4SFTPB, TTN
13polymyositis30.4SFTPD, TTN, GAA
14newborn respiratory distress syndrome30.3SFTPB, NKX2-1
15spinal muscular atrophy30.2GAA, IGHMBP2
16pulmonary alveolar proteinosis30.2SFTPB, SFTPD, SFTPC
17dermatomyositis30.2SFTPD, GAA
18motor neuron disease30.2IGHMBP2, GAA
19adult respiratory distress syndrome30.1SFTPD, SFTPB, SFTPC
20thymoma30.0NKX2-1, TTN
21malignant mesothelioma29.6SFTPB, NKX2-1
22lung cancer29.6SFTPD, SCGB1A1, APEX1, NKX2-1, SFTPB
23idiopathic pulmonary fibrosis29.5SFTPB, SCGB1A1, SFTPD, SFTPC
24asthma29.4SFTPD, APEX1, SCGB1A1, SFTPC, SFTPB
25lung adenocarcinoma29.2NKX2-1, SCGB1A1, SFTPC, SFTPD, SFTPB
26cystic fibrosis29.2APEX1, SCGB1A1, SFTPC, SFTPD, SFTPB
27cork-handlers' disease28.7NKX2-1, APEX1, SFTPB, SFTPD, SFTPC, SCGB1A1
28adenocarcinoma28.7SFTPC, SFTPB, NKX2-1, APEX1, SCGB1A1, SFTPD
29neonatal respiratory failure10.8
30hereditary myopathy with early respiratory failure10.6
31myopathy10.6
32status asthmaticus10.5
33influenza10.5
34sclerosing hemangioma10.5SFTPB
35eosinophilic pneumonia10.5
36hypertension10.4
37leukemia10.4
38botulism10.4
39cor pulmonale10.4
40hypophosphatemia10.4
41obstructive lung disease10.4
42tuberculosis10.4
43distal muscular dystrophy10.3GAA, TTN
44lambert-eaton myasthenic syndrome10.3
45nemaline myopathy10.3
46myopathy congenital10.3TTN, GAA
47spinal muscular atrophy with respiratory distress 110.3
48miliary tuberculosis10.3
49cervicitis10.3
50esophagitis10.3

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Symptoms for Respiratory Failure

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Drugs & Therapeutics for Respiratory Failure

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Drug clinical trials:

Search ClinicalTrials for Respiratory Failure

Search NIH Clinical Center for Respiratory Failure

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Respiratory Failure

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Anatomical Context for Respiratory Failure

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MalaCards organs/tissues related to Respiratory Failure:

32
Lung, Heart, Brain, Spinal cord, Thyroid, Kidney, Liver, Testes, Neutrophil, Skeletal muscle, Myeloid, Monocytes, T cells, Bone marrow, Bone, Breast, Skin, Placenta, Hypothalamus

Animal Models for Respiratory Failure or affiliated genes

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MGI Mouse Phenotypes related to Respiratory Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2IGHMBP2, TTN, APEX1, GAA, SLC4A1
2MP:00020068.2NKX2-1, APEX1, SCGB1A1, SFTPC
3MP:00053868.0IGHMBP2, SFTPB, SFTPC, TTN, NKX2-1, GAA
4MP:00053887.7IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, NKX2-1
5MP:00053857.3IGHMBP2, SFTPC, TTN, APEX1, NKX2-1, GAA
6MP:00053877.0SFTPD, SFTPC, SCGB1A1, TTN, APEX1, SLC4A1
7MP:00053766.5IGHMBP2, SFTPB, SFTPD, SCGB1A1, TTN, APEX1
8MP:00053786.3SLC4A1, IGHMBP2, SFTPD, SFTPC, SCGB1A1, TTN
9MP:00107686.3IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, TTN

Publications for Respiratory Failure

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Articles related to Respiratory Failure:

(show top 50)    (show all 955)
idTitleAuthorsYear
1
An International Survey on Noninvasive Ventilation Use for Acute Respiratory Failure in General Non-Monitored Wards. (25406347)
2014
2
Intravenous colistin-induced acute respiratory failure: A case report and a review of literature. (25337492)
2014
3
Viral pneumonia in severe respiratory failure. (24602995)
2014
4
A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy. (25150234)
2014
5
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
6
Respiratory failure in a mouse model of myotonic dystrophy does not correlate with the CTG repeat length. (23811192)
2013
7
Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. (24215648)
2013
8
Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. (23335231)
2013
9
Acute respiratory failure in a rapidly enlarging benign cervical goitre. (23878293)
2013
10
A patient with severe respiratory failure caused by novel human coronavirus. (23900771)
2013
11
Extracorporeal membrane oxygenation as treatment for acute respiratory failure and subsequent pneumothorax caused by Pneumocystis jirovecii pneumonia in a kidney transplant recipient. (23279741)
2013
12
Clinical review: Early treatment of acute lung injury - paradigm shift toward prevention and treatment prior to respiratory failure. (22713281)
2012
13
State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure. (23134246)
2012
14
Efficacy of intraoperative, single-bolus corticosteroid administration to prevent postoperative acute respiratory failure after oesophageal cancer surgery. (22745302)
2012
15
The pulmonary circulation in neonatal respiratory failure. (22954275)
2012
16
Noninvasive positive pressure ventilation for chronic respiratory failure patients with stable chronic obstructive pulmonary disease (COPD): an evidence-based analysis. (23074437)
2012
17
A middle aged man with respiratory failure and weakness. (22772940)
2012
18
Race and respiratory failure: we need to learn more. (22511158)
2012
19
Single site venovenous extracorporeal membrane oxygenation as an alternative to invasive ventilation in post-pneumonectomy fistula with acute respiratory failure. (22219410)
2012
20
The long duration of extracorporeal membrane oxygenation in a child with acute severe hypoxic respiratory failure treated in a resource-limited center. (22802004)
2012
21
An achondroplasic case with foramen magnum stenosis, hydrocephaly, cortical atrophy, respiratory failure and sympathetic dysfunction. (23056871)
2012
22
Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology. (22052861)
2011
23
Noninvasive ventilation for acute respiratory failure in patients with hematologic malignancies: what an Italian 5-year multicenter survey tells us. (21926491)
2011
24
Non-invasive ventilation for surgical patients with acute respiratory failure. (22066065)
2011
25
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect. (21867529)
2011
26
Significance of herpesvirus 6 in BAL fluid of hematology patients with acute respiratory failure. (21538037)
2011
27
Plasma orexin-a levels in COPD patients with hypercapnic respiratory failure. (21765621)
2011
28
Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus. (19092662)
2009
29
Adjunctive pharmacotherapy in neonates with respiratory failure. (18851933)
2009
30
Bilateral pulmonary contusion, flail chest and respiratory failure on late iatrogenic diaphragmatic eventration and severe kyphoskoliosis: a case report. (19040741)
2008
31
Interleukin-1 receptor antagonist intron 2 variable number of tandem repeats polymorphism and respiratory failure in children with community-acquired pneumonia. (18838927)
2008
32
Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. (19469095)
2008
33
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. (18450855)
2008
34
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006
35
Utility of B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in evaluation of respiratory failure in critically ill patients. (16002948)
2005
36
Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients. (12917010)
2004
37
Venovenous extracorporeal membrane oxygenation in neonatal respiratory failure: does routine, cephalad jugular drainage improve outcome? (15136997)
2004
38
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
39
Acute neonatal respiratory failure and Chlamydia trachomatis. (11287694)
2001
40
Opioid peptides attenuate blood pressure increase in acute respiratory failure. (11311734)
2001
41
Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)
1999
42
Intratracheal pulmonary ventilation in neonatal respiratory failure. (9934880)
1999
43
Engraftment syndrome and survival after respiratory failure post-bone marrow transplantation. (9722046)
1998
44
Respiratory failure in nemaline myopathy. (9744641)
1998
45
Respiratory failure following oral administration of metoclopramide. (9793592)
1998
46
Pulmonary alveolar proteinosis with respiratory failure--therapeutic role of bronchoscopic and whole lung lavage. (11229289)
1998
47
Evaluation and treatment of respiratory failure in neuromuscular disease. (9156393)
1997
48
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life. (1609376)
1992
49
Extracorporeal membrane oxygenation in neonatal respiratory failure. A brief overview. (2681581)
1989
50
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (3860734)
1985

Variations for Respiratory Failure

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Expression for genes affiliated with Respiratory Failure

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Expression patterns in normal tissues for genes affiliated with Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

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Pathways related to Respiratory Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FOXA transcription factor networks37
9.3SCGB1A1, SFTPD
29.3SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 28IUPHAR, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Respiratory Failure according to GeneCards/GeneDecks:

(show all 48)
idCompoundScoreTop Affiliating Genes
1infasurf4410.1SFTPC, SFTPB
2popg4410.1SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.1SFTPB, SFTPC
4dppg4410.1SFTPB, SFTPC
5curosurf4410.1SFTPC, SFTPB
62,4-dinitrophenol4410.1NKX2-1, SFTPB
7survanta4410.1SFTPB, SFTPC
8dopc4410.1SFTPB, SFTPC
9dppc4410.1SFTPC, SFTPB
10p-opc4410.0SFTPB, SFTPC
11butanol4410.0SFTPB, SFTPC
12chloroform4410.0SFTPC, SFTPB
13ozone4410.0SFTPB, SCGB1A1
14gold449.9GAA, TTN, SFTPB
15methanol44 2410.9SFTPC, SFTPB
16maltose44 1110.8SFTPD, GAA
17isoleucine449.8SFTPC, SFTPB
18peroxynitrite449.7SLC4A1, SFTPC, SFTPB
19doxycycline44 1110.6SFTPB, SFTPC, SCGB1A1
20mannose449.5SFTPD, GAA, SLC4A1
21ribonucleic acid449.5SFTPB, SFTPC, NKX2-1
22fatty acid449.4SFTPB, SFTPC, GAA
23phosphatidylcholine449.4SFTPC, SFTPD, SFTPB
24hydrogen44 2410.4SFTPB, SFTPC, TTN, SLC4A1
25polyacrylamide449.3SFTPB, TTN, APEX1
26creatinine449.3GAA, TTN, SCGB1A1
27lysine449.3SLC4A1, TTN, SFTPC
28bleomycin44 1110.2SFTPB, SFTPC, APEX1
29anti-fungal449.2SFTPD, APEX1
30potassium44 24 1111.2SLC4A1, APEX1, TTN
31threonine449.2NKX2-1, TTN, SFTPC, SFTPB
32paraffin449.1NKX2-1, APEX1, SFTPB
33leucine449.0SFTPB, SFTPD, SFTPC, SLC4A1
34lactate449.0SFTPD, GAA, SLC4A1
35cholesterol44 28 24 1112.0SLC4A1, SFTPC, SFTPD, SFTPB
36cyclic amp44 249.9NKX2-1, SFTPC, SFTPD, SFTPB
37atp44 289.9SLC4A1, APEX1, TTN, SFTPB
38thymidine44 249.9GAA, SFTPD, SFTPB
39dexamethasone44 50 28 1111.9NKX2-1, SFTPC, SFTPD, SFTPB
40chloramphenicol44 2 50 1111.7SFTPB, SFTPC, SCGB1A1, APEX1
41phospholipid448.6SLC4A1, SCGB1A1, SFTPC, SFTPD, SFTPB
42glucose448.5SFTPD, APEX1, GAA, SLC4A1
43nitric oxide44 24 1110.3SLC4A1, APEX1, SCGB1A1, SFTPD, SFTPB
44serine448.2SFTPB, SFTPD, TTN, APEX1, NKX2-1
45lipid448.2SFTPB, SFTPD, SFTPC, SCGB1A1, GAA, SLC4A1
46oxygen44 249.1SFTPB, SFTPD, SFTPC, SCGB1A1, APEX1
47cysteine448.0SFTPB, SFTPD, SFTPC, TTN, APEX1, SLC4A1
48calcium44 50 24 1110.7SFTPB, SFTPD, SFTPC, SCGB1A1, TTN, APEX1

GO Terms for genes affiliated with Respiratory Failure

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Cellular components related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:0057648.9GAA, SFTPD, SFTPB
2extracellular spaceGO:0056158.5SCGB1A1, SFTPC, SFTPD, SFTPB

Biological processes related to Respiratory Failure according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cardiac muscle contractionGO:0600489.8GAA, TTN
2locomotory behaviorGO:0076269.7NKX2-1, GAA
3negative regulation of T cell proliferationGO:0421309.4SCGB1A1, SFTPD
4response to glucocorticoidGO:0513849.3SCGB1A1, SFTPC
5regulation of mRNA stabilityGO:0434889.2SCGB1A1, APEX1
6respiratory gaseous exchangeGO:0075859.2SFTPC, SFTPD, SFTPB
7DNA recombinationGO:0063108.9IGHMBP2, APEX1

Molecular functions related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.4SLC4A1, NKX2-1, APEX1, TTN, SCGB1A1, SFTPC

Products for genes affiliated with Respiratory Failure

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  • Antibodies
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Sources for Respiratory Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet