Respiratory Failure malady

MedlinePlus: Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute²³

MalaCards: Respiratory Failure, also known as chronic respiratory failure, is related to neonatal respiratory failure and muscular dystrophy. An important gene associated with Respiratory Failure is SFTPB (surfactant protein B), and among its related pathways are Bacterial infections in CF airways and RAR-Gamma-RXR-Alpha Degradation. The drugs naloxone and nalmefene and the compounds glucose and citrate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

CDC: Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.²

Wikipedia: Respiratory failure is inadequate gas exchange by the respiratory system, with the result that arterial...⁴⁴ more...

Aliases & Descriptions:

respiratory failure 6 17 8 32 23 43 chronic respiratory failure 6 32 43 acute respiratory failure 6 32 43 respiratory failure nos (context-dependent category) 6 respiratory failure (context-dependent category) 6 acute-on-chronic respiratory failure (disorder) 6 chronic respiratory failure (disorder) 6 acute and chronic respiratory failure 6 chronic disease of respiratory system 43

acute respiratory failure (disorder) 6 acute on chronic respiratory failure 6 respiratory insufficiency/failure 6 respiratory failure (disorder) 6 chronic respiratory disease 32 respiratory failure nos 6 respiration disorders 43 respiratory disease 32

Diseases related to respiratory failure by text searches and GeneDecks gene sharing:

(show top 50)    (show all 992)

id	Related Disease	Score	Top Affiliating Genes
1	neonatal respiratory failure	33.6	SFTPB, TRPS1, ABCA7
2	muscular dystrophy	30.9	PIK3C2A, SEPN1, MUSK, LAMA2, FKRP, LOC619409
3	pulmonary hypertension	29.9	SFTPB, SFTPC, EDN1, ELANE, HBG2, THBD
4	sepsis	29.5	IL10, TNF, LTA
5	limb-girdle muscular dystrophy	29.4	PIK3C2A, LAMA2, FKRP, TTN
6	spinal muscular atrophy	29.3	CHAT, IGHMBP2, NDUFS4, TK2, GAA
7	acute interstitial pneumonia	29.3	PIK3C2A, SFTPC, SFTPD, SCGB1A1, THBD, CSF3
8	mitochondrial encephalomyopathy	29.1	MB, NDUFS4, TK2, DNAH8, RYR1
9	parkinson's disease	28.7	BCHE, CHAT, MAPT, NDUFS4, ACHE, HCRT
10	bronchitis	28.7	SERPINA1, CFTR, IL5, IL8, ELANE, PRTN3
11	muscular atrophy	28.6	RDH11, CHAT, IL5, IGHMBP2, IFNG, NDUFS4
12	status asthmaticus	28.5	PIK3C2A, IL1R1, IL1RN, IL5, IL8, HBG2
13	chronic obstructive pulmonary disease	28.1	SFTPB, SFTPD, SERPINA1, SCGB1A1, CFTR, ITGAM
14	idiopathic interstitial pneumonia	28.0	SFTPC, SFTPD, SCGB1A1, IL8, ICAM1, EDN1
15	congenital diaphragmatic hernia	27.9	SFTPB, SFTPC, PAOX, SCGB1A1, FGF7, AQP5
16	calciphylaxis	27.9	PIK3C2A, INS, ALB, PTHLH, EPO
17	adult respiratory distress syndrome	27.8	SFTPB, SERPINA1, IL1R1, IL8, TNF, ELANE
18	relapsing polychondritis	27.8	IL10, IL8, IFNG, CRP, PRTN3
19	cor pulmonale	27.4	REN, SERPINC1, SEPN1, PAOX, MB, SMOX
20	atopic dermatitis	27.0	ITGAM, IL10, IL5, IL8, IFNG, ICAM1
21	iron deficiency anemia	26.8	MB, ALB, TNF, HBG2, TF, CSF3
22	obstructive lung disease	26.7	REN, SFTPC, SERPINA1, ALB, TNF, LTA
23	sleep disorder	26.6	INS, IL1R1, IL6, IL8, ICAM1, ALB
24	hernia	26.4	PIK3C2A, SFTPB, RBP4, SCGB1A1, FGF7, AQP5
25	allergic asthma	26.2	SFTPD, SCGB1A1, ITGAM, IL10, IL3, IL5
26	multiple system atrophy	25.8	CHAT, IL10, IL1B, IL6, IL8, MAPT
27	lipodystrophy	25.7	RBP4, CD4, ITGAM, INS, IL6, GPT
28	aspergillosis	25.4	SFTPD, CFTR, CD4, IL10, IL1B, IL1R1
29	eosinophilic pneumonia	25.2	SFTPD, IL10, IL1B, IL1RN, IL3, IL5
30	silicosis	25.2	SFTPD, SCGB1A1, CDKN2A, IL10, IL1B, IL1RN
31	myasthenia gravis	25.1	BCHE, CHAT, MUSK, INS, IL10, IL5
32	cork-handlers' disease	25.0	SFTPC, CFTR, INS, FGF7, IL1RN, IL6
33	emphysema	25.0	SFTPB, SFTPC, SFTPD, SERPINA1, SCGB1A1, CFTR
34	amyotrophic lateral sclerosis	24.9	SCNN1A, CHAT, IL8, MB, ANXA5, MAPT
35	choriocarcinoma	24.8	CGB5, INS, FGF7, IL1B, ANXA5, IFNG
36	pulmonary edema	24.7	PIK3C2A, REN, SERPINC1, SCGB1A1, SCNN1A, CFTR
37	chorioamnionitis	24.3	SERPINC1, CGB5, FGF7, IL10, IL1B, IL1R1
38	atopy	24.2	SCGB1A1, CFTR, IL10, IL1B, IL1RN, IL3
39	esophageal cancer	24.2	CDKN2A, FGF7, IL10, IL1B, IL1RN, IL6
40	hypothyroidism	23.9	PIK3C2A, REN, RBP4, SERPINC1, SERPINA7, CGB5
41	septic shock	23.9	PIK3C2A, SFTPB, SERPINC1, ITGAM, IL10, IL1B
42	sarcoidosis	23.8	PIK3C2A, SFTPD, SCGB1A1, CFTR, CD4, ITGAM
43	neutropenia	23.4	ITGAM, IL10, IL1B, IL1R1, IL1RN, IL3
44	measles	23.2	SFTPD, RBP4, CD4, IL10, IL1B, IL1RN
45	acute myeloid leukemia	23.2	PIK3C2A, REN, CDKN2A, ITGAM, IL1B, IL1R1
46	asthma	23.1	SFTPB, SFTPC, SFTPD, SERPINA7, SERPINA1, SCGB1A1
47	dermatitis	22.8	PIK3C2A, SFTPD, CD4, ITGAM, IL10, IL1B
48	pulmonary fibrosis	22.4	SFTPB, SFTPC, SFTPD, SERPINA1, SCGB1A1, CDKN2A
49	myopathy	22.3	PIK3C2A, SEPN1, CHAT, MUSK, LAMA2, CD4
50	severe acute respiratory syndrome	22.3	SFTPD, SERPINC1, CD4, IL10, IL1B, IL6

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 nalmefene, nalmefene hydrochloride, naloxone, naloxone hydrochloride

MalaCards organs/tissues related to respiratory failure:

²²

MGI Mouse Phenotypes related to respiratory failure:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	10.1	NKX2-1, LTA, IFNG, GPBAR1, AQP5, LAMA2
2	respiratory system phenotype	MP:0005388	10.1	IGHMBP2, ALPL, TRPS1, NDUFS4, ABCA3, ACHE
3	hematopoietic system phenotype	MP:0005397	9.6	LAMA2, FGF7, IL3, IL5, MB, ALPL
4	craniofacial phenotype	MP:0005382	9.5	EDN1, ACHE, TTN, CSF2, RYR1, PTPN11
5	renal/urinary system phenotype	MP:0005367	9.5	ADM, SLC4A1, NPPA, TSC1, ABCA7, ABCA3
6	embryogenesis phenotype	MP:0005380	9.0	CSF2, DCTN1, TTN, PTPN11, ALPL, F2
7	no phenotypic analysis	MP:0003012	8.9	ACHE, PTPN11, TNFRSF9, GPBAR1, MAPT, AQP5
8	skeleton phenotype	MP:0005390	8.6	PTPN11, PLAT, NDUFS4, ACTA1, TTN, TSC1
9	reproductive system phenotype	MP:0005389	8.4	IFNG, ALPL, TNF, PTPN11, ACHE, TSC1
10	liver/biliary system phenotype	MP:0005370	8.4	ACTA1, ACADVL, TK2, ADM, EPO, PLA2G1B
11	adipose tissue phenotype	MP:0005375	8.3	ACE, ACHE, ACTA1, ACADVL, TK2, CSF2
12	integument phenotype	MP:0010771	8.3	PTHLH, PTPN11, NDUFS4, TK2, CSF2, CSF3
13	immune system phenotype	MP:0005387	8.1	MAPT, PRTN3, CSF2, SLC4A1, ADM, TTN
14	digestive/alimentary phenotype	MP:0005381	7.7	PTHLH, PLA2G1B, PLAT, EDN1, NPY, RYR1
15	growth/size phenotype	MP:0005378	7.5	CFTR, ALPL, TRPS1, PTHLH, PTPN11, PLA2G1B
16	tumorigenesis	MP:0002006	7.3	TNF, PTPN11, ACE, ACADVL, ELANE, HINT1
17	muscle phenotype	MP:0005369	7.0	IGHMBP2, ACTA1, ACADVL, HCRT, TTN, TSC1
18	nervous system phenotype	MP:0003631	7.0	ACHE, EDN1, NDUFS4, LTA, PTPN11, HCRT
19	behavior/neurological phenotype	MP:0005386	6.6	REN, SFTPB, SFTPC, SCNN1A, CHAT, MAPT
20	normal phenotype	MP:0002873	6.5	F3, F2, ALB, PTPN11, NDUFS4, ELANE
21	mortality/aging	MP:0010768	5.6	SCNN1A, CHAT, MUSK, LAMA2, CFTR, CD4
22	cellular phenotype	MP:0005384	4.7	TTN, HINT1, ACADVL, ACE, NDUFS4, LTA
23	cardiovascular system phenotype	MP:0005385	3.6	ACE, RYR1, NKX2-1, ECEL1, ADM, EPO
24	homeostasis/metabolism phenotype	MP:0005376	3.5	ABCA3, TK2, THBD, TF, CSF2, NPPA
25	vision/eye phenotype	MP:0005391	INF	PTHLH, TNFRSF9, TNF, F3, ICAM1, PTPN11

Articles related to respiratory failure:

(show top 50)    (show all 86)

id	Title	Authors	Year	Affiliating Genes
1	Plasma orexin-a levels in COPD patients with hypercap nic respiratory failure. (21765621)	Zhu L.Y.... Qu J.M.	2011	HCRT
2	Lethal respiratory failure and mild primary hypothyroidism in a term girl with a de novo heterozygous mutation in the TITF1/NKX2.1 gene. (18957494)	Maquet E.... DeladoAy J.	2009	NKX2-1
3	Severe congenital myasthenia gravis of the presynaptic type with choline acetyltransferase mutation in a Chinese infant with respiratory failure. (18797171)	Yeung W.L.... Ng P.C.	2009	CHAT
4	Interleukin-1 receptor antagonist intron 2 variable number of tandem repeats polymorphism and respiratory failure in children with community-acquired pneumonia. (18838927)	Patwari P.P.... Dahmer M.K.	2008	IL1RN
5	Angiotensin-converting enzyme D allele does not influence susceptibility to acute hypoxic respiratory failure in children. (18787808)	Plunkett A.... Peters M.J.	2008	ACE
6	The -1082 interleukin-10 polymorphism is associated with acute respiratory failure after major trauma: a prospective cohort study. (18242340)	Schroeder O.... Laun R.A.	2008	IL10
7	Acute respiratory failure in adult patients with dengue virus infection. (17620647)	Wang C.C.... Lin M.C.	2007	F2, ALB, F3
8	Inhaled nitric oxide combined with prostacyclin and adrenomedullin in acute respiratory failure with pulmonary hypertension in piglets. (17902148)	Dani C.... Rubaltelli F.F.	2007	ADM
9	Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. (17426196)	Karmpaliotis D.... Morrow D.	2007	NPPB
10	A case of sarcoidosis presenting with high fever and rash progressing to acute respiratory failure (17929471)	Shibata S.... Ieki R.	2007	ACE
11	Respiratory failure, juvenile myelomonocytic leukemia, and neonatal Noonan syndrome. (17414570)	Cheong J.L.... Moorkamp M.H.	2007	PTPN11
12	Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). (17106167)	Ando M.... Kumamoto T.	2006	CSF3
13	Respiratory failure in infants due to spinal muscular atrophy with respiratory distress type 1. (16964485)	Giannini A.... Nardocci N.	2006	IGHMBP2
14	Very long-chain acyl-CoA dehydrogenase deficiency presenting as acute hypercapnic respiratory failure. (16880373)	Tong M.K.... Tang N.L.	2006	ACADVL
15	Surfactant protein B deficiency: a rare cause of respiratory failure in a Lebanese newborn. (16521884)	Ferzli G.... Mroueh S.	2006	SFTPB
16	The effects of a neutrophil elastase inhibitor on the postoperative respiratory failure of acute aortic dissection. (16967377)	Furusawa T.... Amano J.	2006	ELANE
17	Two cases of acute respiratory failure due to idiopathic interstitial pneumonia successfully treated with sivelestat sodium hydrate and steroid therapy (16502863)	Imokawa S.... Chida K.	2006	ELANE
18	Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients. (12917010)	Pavlisa G.... Jaksic B.	2004	EPO
19	Acute eosinophilic pneumonia with respiratory failure : a case likely triggered by cigarette smoking. (15366338)	Grossi E.... Poletti V.	2004	IL5
20	C-reactive protein and body mass index predict outcome in end-stage respiratory failure. (15302742)	Cano N.J.... Pison C.M.	2004	TTR
21	Cardiac and respiratory failure in limb-girdle muscular dystrophy 2I. (15505776)	Poppe M.... Bushby K.	2004	FKRP
22	Surfactant protein B deficiency in infants with respiratory failure. (15027668)	Wilder M.A.	2004	SFTPB
23	An English kindred with a novel recessive tauopathy and respiratory failure. (14595660)	Nicholl D.J.... Heutink P.	2003	MAPT
24	Acute respiratory failure after interferon-gamma therapy of end-stage pulmonary fibrosis. (12663336)	HonorAc I.... Crestani B.	2003	IFNG
25	Invasive pulmonary aspergillosis resulting in respiratory failure during neutrophil recovery from postchemotherapy neutropenia in three patients with acute leukaemia. (12190893)	Takuma T.... Sawae Y.	2002	CSF3
26	Article reviewed: Sleep-disordered breathing and respiratory failure in acid maltase deficiency. (14592241)	Iranzo A.	2002	GAA
27	Opioid peptides attenuate blood pressure increase in acute respiratory failure. (11311734)	Fontana F.... Spampinato S.	2001	NPPA
28	Sleep-disordered breathing and respiratory failure in acid maltase deficiency. (11591850)	Mellies U.... Teschler H.	2001	GAA
29	Thyroid function in neonates with severe respiratory failure on extracorporeal membrane oxygenation. (11761086)	Stewart D.L.... Cook L.N.	2001	SERPINA7
30	Elevated plasma surfactant protein-B predicts development of acute respiratory distress syndrome in patients with acute respiratory failure. (11520731)	Bersten A.D.... Doyle I.R.	2001	SFTPB
31	Respiratory failure associated with the lipodystrophy syndrome in an HIV-positive patient with compromised lung function. (11521144)	Press N.... Montaner J.	2001	INS
32	Acute respiratory failure due to 'pulmonary calciphylaxis' in a maintenance haemodialysis patient. (11174029)	Matsuo T.... Saegusa N.	2001	PTHLH
33	Apoptosis in cells of bronchoalveolar lavage: a cellular reaction in patients who die with sepsis and respiratory failure. (11801832)	Liacos C.... Androulakis G.	2001	ANXA5
34	Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure. (10931427)	Iwatani N.... Miike T.	2000	NKX2-1
35	Suppressive effect of sarpogrelate hydrochloride on respiratory failure and right ventricular failure with pulmonary hypertension in patients with systemic sclerosis. (11191719)	Kato S.... Kaneko N.	2000	THBD
36	Clearance of Clara cell secretory protein 16 (CC16) and surfactant proteins A and B from blood in acute respiratory failure. (9817704)	Doyle I.R.... Bersten A.D.	1998	SCGB1A1, SFTPB
37	A 60-year-old woman with weakness, fatigue, and acute respiratory failure: case report and discussion of the differential diagnosis. (9795552)	Sander H.W.... Williams D.A.	1998	GAA
38	Endothelin-1 and NO2/NO3 circulating levels after short-term (1h) oxygen supplementation in patients with chronic respiratory failure during long-term oxygen treatment (LTOT). (9736447)	Biondi R.... Capodicasa E.	1998	EDN1
39	Pulmonary toxicity associated with nitric oxide in term infants with severe respiratory failure. (9602194)	Hallman M.... Lappalainen U.	1998	IL1R1
40	Relapsing polychondritis: a case with respiratory failure (9105165)	Kanou A.... Hashimoto H.	1997	CRP
41	Acute respiratory failure associated with G-CSF-induced leukocyte recovery in three patients with preceding infection (9394563)	Sakai C.... Takagi T.	1997	CSF3
42	Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia. The Neonatal Inhaled Nitric Oxide Study Group (NINOS). (9190553)		1997	HBG2
43	Structure and function of the band 3 Cl-/HCO3- transp orter in chronic respiratory failure patients. (9275335)	Yang X.... Mao B.	1996	SLC4A1
44	Respiratory failure in ANCA-associated vasculitis. (8697833)	er Maaten J.C.... Hoorntje S.J.	1996	PRTN3
45	The effect of furosemide and valium on band 3 protein anion transport function in chronic respiratory failure patients (8762500)	Yang X.... Qian G.	1995	SLC4A1
46	Oxygen cost of breathing in patients with emphysema o r chronic bronchitis in acute respiratory failure. (8520795)	Jounieaux V.... Mayeux I.	1995	ALB
47	Biochemical assessment of nutritional status in patients with chronic obstructive pulmonary disease and acute respiratory failure on admission to an intensive care unit. (16843367)	Le Bricon T.... Cynober L.	1994	TF, CRP, TTR
48	Preexisting cardiopulmonary disease attenuating the atrial natriuretic peptide response. Results in patients with acute respiratory failure. (1332838)	Westendorp R.G.... Meinders A.E.	1992	NPPA
49	Acute respiratory failure in pregnancy. (1362144)	Hollingsworth H.M.... Irwin R.S.	1992	TNF
50	ARDS-like reactive respiratory failure after radical operation for esophageal cancer--with reference to PMN elastase and anaphylatoxin (1960448)	Ohwada S.... Morishita Y.	1991	ELANE

Genes related to respiratory failure according to GeneCards:

(show top 50)    (show all 108)

id	Symbol	Description	Score	GeneCards Section Context
1	SFTPB	surfactant protein B	11.0	Publications
2	ECEL1	endothelin converting enzyme-like 1	11.0	Summaries
3	SLC4A1	solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)	11.0	Publications
4	GAA	glucosidase, alpha; acid	11.0	Publications
5	TTN	titin	11.0
6	MAPT	microtubule-associated protein tau	11.0	Publications
7	PIK3C2A	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	11.0
8	LOC619409	muscular dystrophy, congenital, merosin-positive	11.0
9	IGHMBP2	immunoglobulin mu binding protein 2	11.0	Publications
10	NKX2-1	NK2 homeobox 1	11.0	Publications
11	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
12	SFTPC	surfactant protein C	11.0	Publications
13	ALPL	alkaline phosphatase, liver/bone/kidney	11.0
14	ACTA1	actin, alpha 1, skeletal muscle	11.0
15	SFTPD	surfactant protein D	11.0
16	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0
17	NPY	neuropeptide Y	11.0	Publications
18	TSC1	tuberous sclerosis 1	11.0
19	MUSK	muscle, skeletal, receptor tyrosine kinase	11.0
20	CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	11.0
21	DNAH8	dynein, axonemal, heavy chain 8	11.0
22	CCK	cholecystokinin	11.0
23	LAMA2	laminin, alpha 2	11.0	Publications
24	RYR1	ryanodine receptor 1 (skeletal)	11.0
25	BOLA3	bolA homolog 3 (E. coli)	11.0
26	NDUFA5	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13kDa	11.0	Publications
27	SEPN1	selenoprotein N, 1	11.0
28	FKRP	fukutin related protein	11.0	Publications
29	HINT1	histidine triad nucleotide binding protein 1	11.0
30	NFU1	NFU1 iron-sulfur cluster scaffold homolog (S. cerevisiae)	11.0
31	AKR7A3	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	11.0
32	A1BG	alpha-1-B glycoprotein	11.0
33	ANKHD1	ankyrin repeat and KH domain containing 1	11.0
34	GLE1	GLE1 RNA export mediator homolog (yeast)	11.0
35	GKN1	gastrokine 1	11.0
36	CSF2RA	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	11.0	Publications
37	PAOX	polyamine oxidase (exo-N4-amino)	11.0
38	HBG2	hemoglobin, gamma G	11.0	Publications
39	RDH11	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	11.0
40	CSAD	cysteine sulfinic acid decarboxylase	11.0
41	GPBAR1	G protein-coupled bile acid receptor 1	11.0
42	TK2	thymidine kinase 2, mitochondrial	11.0
43	DCTN1	dynactin 1	11.0	Publications
44	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
45	AQP5	aquaporin 5	11.0
46	ACADVL	acyl-CoA dehydrogenase, very long chain	11.0	Publications
47	INTS3	integrator complex subunit 3	11.0	Publications
48	ABCA7	ATP-binding cassette, sub-family A (ABC1), member 7	11.0
49	CPT2	carnitine palmitoyltransferase 2	11.0	Publications
50	SMOX	spermine oxidase	11.0

Pathways related to respiratory failure according to GeneDecks:

(show top 50)    (show all 61)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	IL1R1, CFTR, SFTPD
2	RAR-Gamma-RXR-Alpha Degradation36	10.4	CSF3, CSF2, LTA, IL3
3	Selected targets of C/EBPalpha10	10.2	CSF2RA, TF, ELANE, ALB, SCGB1A1, SERPINC1
4	NFAT Signaling and Lymphocyte Interactions36	9.9	CD4, IL3, IL5
5	Cytokine production by Th17 cells in CF41	9.8	CSF3, CSF2, ICAM1, IL8, IL6, CFTR
6	Immune response_Bacterial infections in normal airways41	9.8	IFNG, IL1R1, IL1B, CFTR
7	Selected targets of CREB110	9.7	CCK, INS, CFTR, MUSK, CHAT, REN
8	Extrinsic Prothrombin Activation Pathway36	9.7	THBD, F2, F3, F5, SERPINC1
9	Regulation of eIF4 and p70S6K36	9.6	IL6, IL5, IL3, FGF7, ITGAM, CD4
10	Immune response_MIF-mediated glucocorticoid regulation41	9.5	TNF, ICAM1, IFNG, IL8, IL6
11	Immune response MIF-mediated glucocorticoid regulation10	9.5	TNF, ICAM1, IFNG, IL8, IL6
12	Amoebiasis20	9.5	CSF2, IL8, IL6, IL1R1, IL1B, ITGAM
13	Jak-STAT signaling pathway20	9.5	EPO, CSF2RA, PTPN11, IL5, IL3, IL10
14	Blood Coagulation Signaling Pathways37	9.4	THBD, PLAT, F2, F3, F5, SERPINC1
15	Complement and coagulation cascades20	9.4	THBD, PLAT, F2, F3, F5, SERPINA1
16	PGC1Alpha Pathway36	9.3	IL8, IL5, IL3, IL1R1, IL1B, CD4
17	Immune response IL-1 signaling pathway10	9.1	EDN1, TNF, F3, IL8, IL6, IL1R1
18	Immune response_IL-1 signaling pathway41	9.1	EDN1, TNF, F3, IL8, IL6, IL1R1
19	Molecular Mechanisms of Cancer36	9.1	IL6, ALK, TNFRSF9, LTA, TSC1, CSF2RA
20	Selected targets of GCR-alpha10	9.1	THBD, IL6, IL1B, INS, CHAT, SCNN1A
21	Selected targets of HNF110	9.1	CRP, ALB, INS, CFTR, SERPINA1
22	Immune response_MIF in innate immunity response41	9.0	TNF, IFNG, IL8, IL6, IL1B
23	Immune response MIF in innate immunity response10	8.9	TNF, IFNG, IL8, IL6, IL1B
24	Rheumatoid arthritis20	8.9	CSF2, TNF, ICAM1, IFNG, IL8, IL6
25	Akt Signaling36	8.9	TNFRSF9, LTA, TSC1, CSF2, CSF2RA, TNF
26	Tec Kinases Signaling36	8.8	CSF2RA, ACTA1, TNFRSF9, IL8, IL6, IL5
27	African trypanosomiasis20	8.7	TNF, ICAM1, IFNG, IL6, IL1B, IL10
28	Rho Family GTPases36	8.6	CSF3, CSF2, LTA, ALK, IL8, IL3
29	Pertussis20	8.6	TNF, IL8, IL6, IL1B, IL10, ITGAM
30	Endothelin-1 Signaling Pathway36	8.6	CSF3, EDN1, PLA2G1B, ALK, IL6, IL5
31	ERK Signaling36	8.6	CSF3, ALK, IL6, IL5, IL3, IL1B
32	all-trans-Retinoic Acid Signaling in Brain36	8.5	TNF, LTA, CSF2, CSF3, IL8, IL6
33	PEDF Induced Signaling36	8.5	TNF, LTA, CSF2, CSF3, IL8, IL6
34	Cytokine Network36	8.5	LTA, TNF, IFNG, IL8, IL6, IL5
35	MIF Mediated Glucocorticoid Regulation36	8.5	CSF3, CSF2, LTA, PLA2G1B, TNF, IL8
36	MIF Regulation of Innate Immune Cells36	8.5	CSF3, CSF2, LTA, PLA2G1B, TNF, IL8
37	IL-6 Pathway36	8.5	CSF3, CSF2, LTA, TNF, IL8, IL6
38	Malaria20	8.4	CSF3, TNF, ICAM1, IFNG, IL8, IL6
39	Chagas disease (American trypanosomiasis)20	8.4	ACE, TNF, IFNG, IL8, IL6, IL1B
40	Hematopoietic cell lineage20	8.4	CD4, EPO, CSF3, CSF2RA, CSF2, TNF
41	PAK Pathway36	8.4	CSF3, CSF2, ACTA1, LTA, TNF, IL8
42	Type I diabetes mellitus20	8.3	LTA, TNF, IFNG, IL1B, INS
43	TGF-Beta Pathway36	7.9	IL6, IL5, IL3, IL1R1, IL1B, IL10
44	STAT3 Pathway36	7.9	TNF, TNFRSF9, LTA, CSF2, CSF2RA, CSF3
45	MAPK Family Pathway36	7.9	IL6, IL8, TNF, LTA, IL5, IL3
46	SOCS Pathway36	7.8	IL8, IL5, IL3, IL1B, IL10, FGF7
47	Antioxidant Action of Vitamin-C36	7.7	TNFRSF9, PLA2G1B, LTA, ACTA1, CSF2, CSF2RA
48	Cytokine-cytokine receptor interaction20	7.7	TNFRSF9, LTA, CSF2, CSF2RA, CSF3, EPO
49	p38 Signaling36	7.6	ALK, TNF, TNFRSF9, LTA, CSF2, CSF2RA
50	JAK-STAT Pathway36	7.2	IL6, IL8, IFNG, F2, ALK, EPO

Compounds related to respiratory failure according to GeneDecks:

(show top 50)    (show all 474)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.7	PTHLH, TSC1, OGDH, CSF2RA, RYR1, GAA
2	citrate32	10.4	PIK3C2A, CFTR, INTS3, MB, NDUFS4, OGDH
3	nicotine32 34 9 9	13.4	GPT, PTHLH
4	ivig32	10.0	PIK3C2A, IL3, CRP, LTA, CSF2
5	polyethylene glycol32	9.7	SERPINC1, BCHE, MB, HBG2, THBD, NPPA
6	hyaluronic acid32 18	10.2	SCGB1A1, FGF7, MB, GPT, F2, LTA
7	aspartate32	9.2	PIK3C2A, RBP4, SERPINA7, SCGB1A1, CHAT, CFTR
8	n acetylcysteine32	9.2	SERPINC1, CFTR, CDKN2A, ITGAM, IL1R1, IL3
9	aprotinin32 9 9	11.0	SERPINC1, MB, F5, F2, PLAT, ELANE
10	oxygen32 18	10.0	PIK3C2A, SFTPB, SFTPC, SFTPD, RBP4, SERPINA1
11	endotoxin32	8.8	SFTPD, SCGB1A1, ITGAM, IL1R1, F5, F3
12	h2o232	8.8	SERPINA1, BCHE, CGB5, CFTR, ITGAM, INTS3
13	pge232	8.7	REN, SFTPB, CGB5, CFTR, CD4, FGF7
14	acetylcholine32 9 18 9	11.6	PIK3C2A, BCHE, CHAT, MUSK, CFTR, FGF7
15	heparin32 9 18 9	11.6	PIK3C2A, SERPINA1, BCHE, MUSK, LAMA2, CD4
16	paraffin32	8.5	SFTPB, SERPINA1, CHAT, CGB5, CFTR, CDKN2A
17	adenylate32	8.5	RBP4, SERPINC1, CGB5, CFTR, ITGAM, FGF7
18	rantes32	8.4	CD4, ITGAM, FGF7, IL1R1, IL3, IL5
19	iron32 18	9.3	PIK3C2A, RBP4, SERPINA7, SERPINA1, PAOX, SCGB1A1
20	glutamate32	8.3	BCHE, CHAT, CFTR, CD4, INS, IL1R1
21	cysteine32	8.3	SFTPB, SFTPC, SFTPD, RBP4, SERPINA1, CFTR
22	testosterone32 9 18 9	11.2	PIK3C2A, SERPINC1, SERPINA7, CHAT, CGB5, CFTR
23	estrogen32	8.1	RBP4, SERPINC1, SERPINA7, SERPINA1, SCGB1A1, CHAT
24	calcium32 9 18 9	10.9	PIK3C2A, REN, SFTPB, SFTPC, SFTPD, RBP4
25	arginine32	7.8	PIK3C2A, REN, SFTPB, SFTPC, SERPINC1, SERPINA7
26	il 1032	7.6	IL10, IL1B, IL1R1, IL1RN, IL3, IL5
27	vitamin d32	7.6	CFTR, ITGAM, FGF7, IL10, IL1R1, IL1RN
28	gabexate mesilate32	7.5	SERPINC1, IL10, IL6, IL8, F5, TNF
29	thyroxine32 18	8.5	PIK3C2A, REN, RBP4, SERPINA7, INS, IL10
30	aspirin32 34 18	9.5	SERPINC1, SERPINA7, BCHE, CGB5, CFTR, ITGAM
31	indomethacin32 9 9	9.3	REN, CGB5, CFTR, ITGAM, IL1B, IL1R1
32	gm-csf32	7.3	IL10, IL1B, IL3, IL5, IL6, IL8
33	prednisolone32 9 9	9.2	PIK3C2A, SFTPD, ITGAM, IL10, IL1R1, IL1RN
34	genistein32 9 18 9	10.1	CGB5, CFTR, CDKN2A, CD4, ITGAM, FGF7
35	actinomycin d32	7.0	SFTPB, SFTPC, SCNN1A, CGB5, CFTR, CDKN2A
36	norepinephrine32 9 18 9	10.0	PIK3C2A, REN, BCHE, CHAT, CGB5, CFTR
37	thymidine32 18	7.9	SFTPB, SFTPD, SERPINA1, ITGAM, FGF7, IL10
38	vegf32	6.8	PIK3C2A, REN, SFTPB, SFTPC, SERPINC1, CGB5
39	methotrexate32 34 42 9 9	10.7	PIK3C2A, CGB5, CDKN2A, IL10, IL1B, IL1R1
40	fibrinogen32	6.6	PIK3C2A, SFTPB, SFTPC, SERPINC1, SERPINA1, CGB5
41	simvastatin32 34 42 9 18 9	11.5	PIK3C2A, RBP4, BCHE, ITGAM, IL10, IL1RN
42	nitric oxide32 9 18 9	9.5	REN, SFTPB, SFTPD, SERPINA1, SCGB1A1, CHAT
43	prostacyclin32	6.4	PIK3C2A, REN, SERPINC1, IL10, IL1B, IL3
44	tyrosine32	6.3	PIK3C2A, SFTPB, SERPINA7, SERPINA1, CHAT, MUSK
45	lipid32	5.9	PIK3C2A, SFTPB, SFTPC, SFTPD, RBP4, SERPINA7
46	hydrocortisone32 9 9	7.8	REN, INS, FGF7, IL10, IL1B, IL1R1
47	alanine32	5.6	PIK3C2A, RBP4, SERPINC1, SERPINA7, BCHE, SCGB1A1
48	cycloheximide32	5.1	SFTPB, SFTPC, CHAT, CGB5, CDKN2A, CD4
49	serine32	5.1	SFTPB, SFTPD, RBP4, SERPINC1, SERPINA7, SERPINA1
50	lactate32	4.6	PIK3C2A, SFTPD, RBP4, BCHE, CHAT, CGB5

Cellular components related to respiratory failure according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:009897	8.8	TNFRSF9, TNF, ICAM1, IFNG, ANXA5, CD4
2	secretory granule	GO:030141	8.2	TF, HCRT, ELANE, PLAT, PLA2G1B, GKN1
3	extracellular region	GO:005576	3.9	SFTPD, IL1R1, IL3, IL5, IL6, IL8
4	extracellular space	GO:005615	2.9	REN, IL1B, IL1RN, IL3, IL5, IL6

Biological processes related to respiratory failure according to GeneDecks:

(show all 27)

id	Name	GO ID	Score	Top Affiliating Genes
1	respiratory gaseous exchange	GO:007585	10.5	EDN1, CFTR, SFTPD, SFTPC, SFTPB
2	positive regulation of podosome assembly	GO:071803	10.3	CSF2, TNF, IL5
3	female pregnancy	GO:007565	10.2	ADM, NPPA, THBD, PTHLH, IL1RN, SCGB1A1
4	positive regulation of immunoglobulin secretion	GO:051024	10.1	IL6, IL5, RBP4
5	response to cAMP	GO:051591	10.1	REN, SFTPC, PLAT, NDUFS4, THBD
6	chronic inflammatory response to antigenic stimulus	GO:002439	9.9	TNF, IL1RN, IL1B
7	response to insulin stimulus	GO:032868	9.8	RBP4, IL10, TSC1, NPPA, ADM
8	response to lipopolysaccharide	GO:032496	9.8	ELANE, THBD, NKX2-1, ADM, EPO, EDN1
9	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.7	TNF, IFNG, IL1B
10	negative regulation of lipid storage	GO:010888	9.7	CRP, TNF, IL6
11	negative regulation of growth of symbiont in host	GO:044130	9.5	ELANE, LTA, TNF, IFNG, IL10
12	neutrophil chemotaxis	GO:030593	9.4	EDN1, PLA2G1B, IFNG, IL8, IL1B
13	leukocyte migration	GO:050900	9.2	THBD, ELANE, PTPN11, F2, ICAM1, ITGAM
14	positive regulation of DNA replication	GO:045740	9.2	EPO, CSF2, PLA2G1B, IL3, INS
15	positive regulation of chemokine biosynthetic process	GO:045080	9.2	IL1B, IFNG, TNF
16	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	8.9	CCK, IL6, IL5, IL3, FGF7, INS
17	acute-phase response	GO:006953	8.8	CRP, F2, IL6, IL1RN, INS, SERPINA1
18	response to glucocorticoid stimulus	GO:051384	8.7	SFTPB, ADM, PLAT, TNF, ALPL, IL6
19	small molecule metabolic process	GO:044281	8.7	NDUFS4, ACHE, ACADVL, TK2, OGDH, CSAD
20	blood coagulation	GO:007596	8.6	TF, THBD, TTN, HBG2, PLAT, PTPN11
21	positive regulation of mitosis	GO:045840	8.6	EDN1, TNF, IL1B, INS
22	response to hypoxia	GO:001666	8.6	LTA, EDN1, NPPB, RYR1, ADM, PLAT
23	positive regulation of nitric oxide biosynthetic process	GO:045429	8.4	EDN1, TNF, ICAM1, IFNG, IL1B, INS
24	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.4	PLA2G1B, TNF, ALK, ICAM1, IL6, IL1B
25	response to drug	GO:042493	8.4	TNF, LTA, EDN1, ABCA3, NPPB, ICAM1
26	positive regulation of cell proliferation	GO:008284	8.1	EDN1, PRTN3, CSF2, CSF3, ADM, EPO
27	cell-cell signaling	GO:007267	7.8	EDN1, LTA, PTHLH, IL3, IL1B, IL10

Molecular functions related to respiratory failure according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone receptor binding	GO:051428	9.9	NPPB, NPPA, PTPN11, PTHLH
2	choline binding	GO:033265	9.8	BCHE, CHAT, CRP
3	receptor binding	GO:005102	9.2	ADM, NPY, NPPB, NPPA, LTA, PLA2G1B
4	protease binding	GO:002020	9.0	SERPINC1, RYR1, TTN, ELANE, TNF, F3
5	hormone activity	GO:005179	8.6	EPO, ADM, NPPB, NPPA, TTR, EDN1
6	growth factor activity	GO:008083	8.2	CSF3, CSF2, GKN1, F2, IL6, IL5
7	cytokine activity	GO:005125	7.9	CSF3, CSF2, EDN1, LTA, TNF, IFNG
8	protein binding	GO:005515	4.1	ACE, ACHE, ACTA1, ELANE, NFU1, PLAT