MCID: RSP003
MIFTS: 60

Respiratory Failure malady

Respiratory, Fetal categories

Summaries for Respiratory Failure

Sources:
34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards: Respiratory Failure, also known as chronic respiratory failure, is related to pulmonary disease, chronic obstructive and polymyositis. An important gene associated with Respiratory Failure is ECEL1 (endothelin converting enzyme-like 1), and among its related pathways is FOXA1 transcription factor network. The drugs naloxone and nalmefene and the compounds lipid and phospholipid have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and growth/size.

CDC:3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:64 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Aliases & Classifications for Respiratory Failure

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 40NCIt, 57SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Respiratory Failure

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Respiratory Failure family:

severe acute respiratory syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 606)
idRelated DiseaseScoreTop Affiliating Genes
1pulmonary disease, chronic obstructive30.7SERPINA1, SFTPD
2polymyositis30.2TTN, PIK3C2A, GAA, SFTPD
3bronchopulmonary dysplasia30.2SFTPB, SCGB1A1
4pulmonary alveolar proteinosis30.2SFTPB, SFTPD, SFTPC
5rigid spine syndrome30.2LOC619409, GAA
6bronchiolitis obliterans30.2SCGB1A1
7cystic fibrosis30.0SFTPC, SFTPD, SFTPB, SCGB1A1, SERPINA1
8adult respiratory distress syndrome30.0SFTPB, SERPINA1
9cork-handlers' disease29.8SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1, SERPINA1
10adenocarcinoma29.8CCK, SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1
11congenital diaphragmatic hernia29.8SFTPB
12meconium aspiration syndrome29.8TTN, SFTPB
13thymoma29.8NKX2-1, MUSK, TTN
14neonatal respiratory failure10.9
15asthma10.6
16status asthmaticus10.5
17hereditary myopathy with early respiratory failure10.5
18n syndrome10.4
19botulism10.4
20hypophosphatemia10.3
21tuberculosis10.3
22lambert syndrome10.3
23nemaline myopathy10.3
24lambert-eaton myasthenic syndrome10.3
25rhinotracheitis10.3
26miliary tuberculosis10.3
27acute leukemia10.3
28bronchiolitis10.2
29myxedema10.2
30pemphigus10.2
31blastomycosis10.2
32renal tubular acidosis10.2
33sepsis10.2
34paraneoplastic pemphigus10.2
35lemierre's syndrome10.2
36protein s deficiency10.2
37scrub typhus10.2
38acute intermittent porphyria10.2
39acute kidney failure10.2
40acute porphyria10.2
41amyotrophic lateral sclerosis10.2
42typhus10.2
43spinal muscular atrophy with respiratory distress 110.2
44protein r deficiency10.2
45thyrotoxic periodic paralysis10.2
46guillain-barr� syndrome10.2
47influenza, severe10.2
48diffuse alveolar hemorrhage10.2
49laryngotracheitis10.1
50acute interstitial pneumonia10.1

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Clinical Features for Respiratory Failure

Drugs & Therapeutics for Respiratory Failure

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Respiratory Failure

Drug clinical trials:

Search ClinicalTrials for Respiratory Failure

Search NIH Clinical Center for Respiratory Failure

Search CenterWatch for Respiratory Failure

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Respiratory Failure

Anatomical Context for Respiratory Failure

Animal Models for Respiratory Failure or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Respiratory Failure

Sources:
51PubMed
See all sources

Articles related to Respiratory Failure:

(show top 50)    (show all 971)
idTitleAuthorsYear
1
The clinical significance of anaemia and disturbed iron homeostasis in chronic respiratory failure. (24341307)
2014
2
The usage of the Boussignac continuous positive airway pressure system in acute respiratory failure. (23419338)
2013
3
Rescue therapy with noninvasive ventilation in do-not-intubate patients in acute respiratory failure: what is the best device among face masks? (23979383)
2013
4
Noninvasive ventilation for acute hypercapnic respiratory failure: intubation rate in an experienced unit. (23737546)
2013
5
Clinical assessment for identifying causes of acute respiratory failure in cancer patients. (23143549)
2013
6
Anemia and performance status as prognostic markers in acute hypercapnic respiratory failure due to chronic obstructive pulmonary disease. (23658480)
2013
7
Titin founder mutation is a common cause of myofibrillar myopathy with early respiratory failure. (23486992)
2013
8
The Prevalence of Sarcopenia in Patients With Respiratory Failure Classified as Normally Nourished Using Computed Tomography and Subjective Global Assessment. (23980135)
2013
9
State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure. (23134246)
2012
10
Bronchoscopic intervention obviates the need for continued mechanical ventilation in patients with airway obstruction and respiratory failure from inoperable non-small-cell lung cancer. (22759948)
2012
11
Long-term evaluation of phrenic nerve pacing for respiratory failure due to high cervical spinal cord injury. (22777487)
2012
12
Nebulized iloprost and noninvasive respiratory support for impending hypoxaemic respiratory failure in formerly preterm infants: a case series. (22170702)
2012
13
Using transcutaneous carbon dioxide monitor (TOSCA 500) to detect respiratory failure in patients with amyotrophic lateral sclerosis: a validation study. (22871078)
2012
14
Noninvasive ventilation in acute hypercapnic respiratory failure caused by obesity hypoventilation syndrome and chronic obstructive pulmonary disease. (23103736)
2012
15
Recurrent episodic hypoxaemic respiratory failure following a stroke. (22859382)
2012
16
Pediatric fiberoptic bronchoscopy as adjunctive therapy in acute asthma with respiratory failure. (22588986)
2012
17
Pulmonary calciphylaxis associated with acute respiratory and renal failure due to cryptogenic hypercalcemia: an autopsy case report. (23323114)
2012
18
Acute respiratory failure complicating advanced liver disease. (22447264)
2012
19
New hopes and better treatment prospects for patients with neuromuscular pathologies and respiratory failure?. (22391840)
2012
20
Strategies for the withdrawal of extracorporeal membrane oxygenation for severe acute respiratory failure support: a new challenge? (22417044)
2012
21
Phrenic nerve CMAP amplitude, duration, and latency could predict respiratory failure in Guillain-Barre syndrome. (22246012)
2012
22
Effect of pulmonary support using extracorporeal membrane oxygenation for adult liver transplant recipients with respiratory failure. (22483488)
2012
23
Noninvasive ventilation for acute respiratory failure in patients with hematologic malignancies: what an Italian 5-year multicenter survey tells us. (21926491)
2011
24
Respiratory failure after pediatric scald injury. (21929985)
2011
25
Sleep hypoventilation syndrome and respiratory failure due to multifocal motor neuropathy with conduction block. (21404292)
2011
26
Palliative noninvasive ventilation in patients with acute respiratory failure. (21656292)
2011
27
Rescue high frequency oscillation in neonates with acute respiratory failure. (21555797)
2011
28
Pentraxin-3 in late-preterm newborns with hypoxic respiratory failure. (20515753)
2010
29
Respiratory failure and acalculous cholecystitis in a patient with AIDS and disseminated tuberculosis: masking effect of fluoroquinolone monotherapy and immune restoration syndrome. (19008140)
2009
30
High cervical neurenteric cyst; acute post-traumatic rupture and respiratory failure: a case report. (18393167)
2008
31
Surfactant protein B deficiency: a rare cause of respiratory failure in a Lebanese newborn. (16521884)
2006
32
Neonatal respiratory failure associated with mutation in the surfactant protein C gene]. (15737281)
2005
33
Cor pulmonale and respiratory failure in a young woman. (16043957)
2005
34
Acute hypercapnic respiratory failure due to thyrotoxic periodic paralysis. (15166747)
2004
35
Infectious mononucleosis, diffuse pneumonia and acute respiratory failure in an elderly woman. (14994978)
2004
36
Zardaverine and aerosolised iloprost in a model of acute respiratory failure. (12952271)
2003
37
Use of activated protein C (drotrecogin alfa) in a patient with sepsis and respiratory failure on ultra high frequency jet ventilation. (12630184)
2003
38
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. (14654609)
2003
39
Opioid peptides attenuate blood pressure increase in acute respiratory failure. (11311734)
2001
40
Mechanical ventilation during pregnancy using a helium-oxygen mixture in a patient with respiratory failure due to status asthmaticus. (11593376)
2001
41
Nursing management of the child in status asthmaticus and impending respiratory failure. (10855115)
1999
42
Pulmonary alveolar proteinosis with respiratory failure--therapeutic role of bronchoscopic and whole lung lavage. (11229289)
1998
43
Partial 3-methylcrotonyl-CoA carboxylase deficiency in an infant with fatal outcome due to progressive respiratory failure. (9537490)
1998
44
Hypophosphatemia and phosphorus depletion in respiratory and peripheral muscles of patients with respiratory failure due to COPD. (8181325)
1994
45
Serum lipofuscin as a prognostic indicator of adult respiratory distress syndrome and multiple organ failure. (7953392)
1994
46
Experimental neonatal respiratory failure induced by a monoclonal antibody to the hydrophobic surfactant-associated protein SP-B. (1945561)
1991
47
Extracorporeal membrane oxygenation for neonatal respiratory failure. A report of 50 cases. (2709862)
1989
48
Sleep apnea contributing to respiratory failure in the Mounier-Kuhn syndrome. (3971720)
1985
49
Chronic eosinophilic pneumonia: an unusual cause of acute respiratory failure. (7416625)
1980
50
Neonatal respiratory failure due to myotonic dystrophy. (1167072)
1975

Genetic Variations for Respiratory Failure

Expression for genes affiliated with Respiratory Failure

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

Sources:
38NCBI BioSystems Database
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Pathways related to Respiratory Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SERPINA1, SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Respiratory Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1lipid4511.0SERPINA1, SFTPC, SFTPD, SFTPB, SCGB1A1, GAA
2phospholipid4511.0SFTPC, SFTPD, SFTPB, SCGB1A1, ABCA7, SLC4A1
3calcium45 50 11 2413.9CCK, SFTPC, SFTPD, SFTPB, NPY, SCGB1A1
4cholesterol45 29 11 2413.9CCK, SFTPC, SFTPD, SFTPB, PIK3C2A, ABCA7
5creatinine4510.9NPY, SCGB1A1, GAA, PIK3C2A, TTN, ACTA1
6peroxynitrite4510.9SFTPC, SFTPB, SLC4A1, SERPINA1
7glucose4510.9CCK, SFTPD, NPY, GAA, PIK3C2A, SLC4A1
8tyrosine4510.9CCK, SFTPB, NPY, PIK3C2A, NKX2-1, MUSK
9chloroform4510.9PIK3C2A, SFTPB, SFTPC
10gold4510.9SFTPB, GAA, PIK3C2A, TTN
11infasurf4510.9SFTPC, SFTPB
12cysteine4510.9SFTPC, SFTPD, SFTPB, TTN, SLC4A1, SERPINA1
13dppg4510.9SFTPC, SFTPB
14popg4510.9SFTPC, SFTPB
151,2-dipalmitoyl-sn-glycero-3-phosphocholine4510.9SFTPC, SFTPB
16acetylcholine45 50 29 11 2414.9TTN, MUSK, PIK3C2A, NPY, CCK
17[met]enkephalin4510.9CCK, NPY
18curosurf4510.9SFTPC, SFTPB
19carbohydrates4510.9GAA, NPY, SFTPD, CCK
20paraffin4510.9TSC1, SERPINA1, NKX2-1, NPY, SFTPB
21dopc4510.9SFTPC, SFTPB
22survanta4510.9SFTPC, SFTPB
23arginine4510.9CCK, SFTPC, SFTPB, NPY, GAA, PIK3C2A
24lactate4510.9SLC4A1, PIK3C2A, GAA, NPY, SFTPD
25nitric oxide45 11 2412.9SFTPD, SFTPB, NPY, SCGB1A1, SLC4A1, SERPINA1
26sucrose45 11 2412.9SFTPB, GAA, ACTA1, ALPL
27acth4510.8SERPINA1, PIK3C2A, NPY, CCK
28cyclo(his-pro)4510.8CCK, NPY
29dppc4510.8SFTPB, SFTPC
30doxycycline45 1111.8SFTPC, SFTPB, SCGB1A1
31cyclic amp45 2411.8SFTPC, SFTPD, SFTPB, NPY, NKX2-1
32octadecaneuropeptide4510.8NPY, CCK
33oxygen45 2411.8SFTPC, SFTPD, SFTPB, SCGB1A1, PIK3C2A, SERPINA1
34bicarbonate4510.8SLC4A1, PIK3C2A, CCK
35retinoic acid45 2411.8CCK, SFTPC, SFTPB, NPY, NKX2-1, ALPL
36bethanechol45 29 1112.8NPY, CCK
37progesterone45 60 29 11 2414.8SFTPB, SCGB1A1, PIK3C2A, NKX2-1, SERPINA1
38butanol4510.7SFTPC, SFTPB
39enterostatin4510.7CCK, NPY
40npff4510.7CCK, NPY
41p-opc4510.7SFTPC, SFTPB
42polysaccharide4510.7CCK, SFTPD, GAA, SERPINA1
43fibrinogen4510.7SERPINA1, PIK3C2A, SFTPB, SFTPC
44alpha msh4510.6CCK, NPY
45incretin4510.6NPY, CCK
46serine4510.6SFTPD, SFTPB, NKX2-1, TTN, ACTA1, SERPINA1
472,4-dinitrophenol4510.5NKX2-1, SFTPB
48glycogen45 2411.5TSC1, TTN, PIK3C2A, GAA
49steroid4510.4SFTPD, SCGB1A1, PIK3C2A, NKX2-1, MUSK
50sodium nitroprusside4510.2PIK3C2A, NPY, CCK

GO Terms for genes affiliated with Respiratory Failure

Sources:
16Gene Ontology
See all sources

Cellular components related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1striated muscle thin filamentGO:00586510.5ACTA1, TTN
2extracellular spaceGO:00561510.2ALPL, CCK, SFTPC, SFTPD, SFTPB, NPY

Biological processes related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:03249610.6SCGB1A1, SFTPC, SERPINA1, ALPL
2respiratory gaseous exchangeGO:00758510.5SFTPB, SFTPC, SFTPD
3regulation of protein kinase activityGO:04585910.5TSC1, TTN
4skeletal muscle thin filament assemblyGO:03024010.4TTN, ACTA1
5response to glucocorticoid stimulusGO:05138410.2ALPL, SCGB1A1, SFTPC

Molecular functions related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5TSC1, SFTPC, SFTPD, SCGB1A1, NKX2-1, IGHMBP2

Products for genes affiliated with Respiratory Failure

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Respiratory Failure

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet