MCID: RSP003
MIFTS: 70

Respiratory Failure malady

Respiratory diseases, Fetal diseases categories

Summaries for Respiratory Failure

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards: Respiratory Failure, also known as chronic respiratory failure, is related to pneumonia and myopathy. An important gene associated with Respiratory Failure is ECEL1 (endothelin converting enzyme-like 1), and among its related pathways is FOXA1 transcription factor network. The drugs naloxone and nalmefene and the compounds lipid and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are homeostasis/metabolism and growth/size.

CDC:3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:63 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Aliases & Classifications for Respiratory Failure

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Respiratory Failure

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17GeneCards, 18GeneDecks
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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 642)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.9SFTPC, SFTPD, SFTPB, SCGB1A1, PIK3C2A, SERPINA1
2myopathy30.7GAA, PIK3C2A, TTN, ACTA1
3neuromuscular disease30.7GAA, MUSK, TTN, ACTA1
4hypertension30.5NPY
5leukemia30.5ALPL, MUSK, SCGB1A1
6lung cancer30.3SFTPC, SFTPB, SCGB1A1, NKX2-1
7muscular dystrophy30.2LOC619409, GAA, PIK3C2A, MUSK, TTN
8interstitial lung disease30.1SFTPD
9pulmonary alveolar proteinosis30.1SFTPB, SFTPD, SFTPC
10pneumothorax30.1TSC1
11bronchiolitis obliterans30.1SCGB1A1
12diarrhea30.0ALPL
13cystic fibrosis30.0SFTPC, SFTPD, SFTPB, SCGB1A1, SERPINA1
14dermatomyositis30.0PIK3C2A, GAA, SFTPD
15dilated cardiomyopathy30.0TTN, PIK3C2A
16pancreatitis30.0ALPL, SERPINA1, CCK
17adult respiratory distress syndrome30.0SFTPB, SERPINA1
18idiopathic pulmonary fibrosis29.9SCGB1A1, SFTPB, SFTPD, SFTPC
19pulmonary disease, chronic obstructive29.9SERPINA1, SFTPD
20cork-handlers' disease29.8SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1, SERPINA1
21lung adenocarcinoma29.8CCK, SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1
22polymyositis29.8TTN, PIK3C2A, GAA, SFTPD
23adenocarcinoma29.8CCK, SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1
24congenital diaphragmatic hernia29.8SFTPB
25meconium aspiration syndrome29.8TTN, SFTPB
26dementia29.8PIK3C2A
27hepatitis29.8SERPINA1
28pulmonary fibrosis29.8SFTPD, SFTPC
29thymoma29.8NKX2-1, MUSK, TTN
30breast cancer29.8SCGB1A1, SERPINA1, TSC1, ALPL
31bronchopulmonary dysplasia29.6SFTPB, SCGB1A1
32neonatal respiratory failure10.9
33hereditary myopathy with early respiratory failure10.6
34status asthmaticus10.5
35influenza10.5
36eosinophilic pneumonia10.4
37botulism10.3
38hypophosphatemia10.3
39obstructive lung disease10.3
40tuberculosis10.3
41rhinotracheitis10.3
42nemaline myopathy10.3
43lambert-eaton myasthenic syndrome10.3
44miliary tuberculosis10.2
45acute leukemia10.2
46cervicitis10.2
47esophagitis10.2
48neuropathy10.2
49polyneuropathy10.2
50bronchiolitis10.2

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Clinical Features for Respiratory Failure

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Drugs & Therapeutics for Respiratory Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Respiratory Failure

Drug clinical trials:

Search ClinicalTrials for Respiratory Failure

Search NIH Clinical Center for Respiratory Failure

Search CenterWatch for Respiratory Failure

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Respiratory Failure

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Anatomical Context for Respiratory Failure

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32MalaCards
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MalaCards organs/tissues related to Respiratory Failure:

32
Lung, Heart, Brain, Spinal cord, Liver, Thyroid, Kidney, Testes, Skeletal muscle, T cells, Monocytes, Myeloid, Placenta, Skin, Breast, Bone marrow, Bone, Hypothalamus

Animal Models for Respiratory Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Respiratory Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.7ALPL, CCK, NPY, SCGB1A1, GAA, PIK3C2A
2MP:000537810.7PIK3C2A, GAA, SCGB1A1, NPY, SFTPD, SFTPC
3MP:000538810.7SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1, IGHMBP2
4MP:001076810.7NKX2-1, PIK3C2A, SCGB1A1, SFTPB, SFTPD, SFTPC
5MP:000536910.6GAA, IGHMBP2, ECEL1, MUSK, TTN, SLC4A1
6MP:000538610.6SFTPC, SFTPB, NPY, GAA, NKX2-1, IGHMBP2
7MP:000539010.5NPY, GAA, NKX2-1, ECEL1, MUSK, TTN
8MP:000537510.5ALPL, ACTA1, ABCA7, PIK3C2A, NPY
9MP:000538510.4SFTPC, GAA, NKX2-1, IGHMBP2, ECEL1, TTN
10MP:000536710.2NPY, SCGB1A1, PIK3C2A, ABCA7, SLC4A1, TSC1

Publications for Respiratory Failure

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Sources:
50PubMed
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Articles related to Respiratory Failure:

(show top 50)    (show all 971)
idTitleAuthorsYear
1
Acute and chronic respiratory failure. (24365302)
2014
2
Blood oxygenation and decarboxylation determinants during venovenous ECMO for respiratory failure in adults. (23291732)
2013
3
H1N1 influenza A virus Related Pneumonia and Respiratory Failure. (24426265)
2013
4
Hydralazine in infants with persistent hypoxemic respiratory failure. (23450605)
2013
5
Early out-of-hospital non-invasive ventilation vs. standard medical treatment in patients with acute respiratory failure. Patient selection is the first priority. (23890689)
2013
6
Acute Stridor and Respiratory Failure due to Retrosternal Subglottic Stenosis of Unknown Origin. (23956890)
2013
7
Extracorporeal membrane oxygenation for the treatment of acute respiratory failure due to respiratory syncytial virus after congenital heart surgery. (23949619)
2013
8
Burden of respiratory viruses in patients with acute respiratory failure. (24108695)
2013
9
Acute respiratory failure from Surgifoam expansion after anterior cervical surgery: case report. (23971761)
2013
10
Acute respiratory failure in goitre patients qualified for operative treatment. (23873426)
2013
11
Race and respiratory failure: we need to learn more. (22511158)
2012
12
Mixed acid-base disorders, hydroelectrolyte imbalance and lactate production in hypercapnic respiratory failure: the role of noninvasive ventilation. (22539963)
2012
13
Severe Dejerine-Sottas disease with respiratory failure and dysmorphic features in association with a PMP22 point mutation and a 3q23 microdeletion. (22734911)
2012
14
Predictive value of daily living score in acute respiratory failure of COPD patients requiring invasive mechanical ventilation pilot study. (23078114)
2012
15
Extracorporeal membrane oxygenation for respiratory failure in adults. (22186218)
2012
16
Sudden atelectasis and respiratory failure in a neutropenic patient: atypical presentation of pseudomembranous necrotizing bronchial aspergillosis. (23269890)
2012
17
Volume targeted versus pressure support non-invasive ventilation in patients with super obesity and chronic respiratory failure: a randomised controlled trial. (22382596)
2012
18
Extracorporeal membrane oxygenation as a platform for recovery: a case report of a child with pulmonary hemorrhage, refractory hypoxemic respiratory failure, and new onset goodpasture syndrome. (22893987)
2012
19
Effectiveness of treatment with surfactant in premature infants with respiratory failure and pulmonary infection. (23029875)
2012
20
Postoperative respiratory failure after cardiac surgery: use of noninvasive ventilation. (22257829)
2012
21
Acute respiratory failure after endoscopic third ventriculostomy: A case report and review of the literature. (23493148)
2012
22
Respiratory pattern during neurally adjusted ventilatory assist in acute respiratory failure patients. (22127483)
2012
23
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect. (21867529)
2011
24
Uneven use of noninvasive ventilation in acute respiratory failure in Europe. (21632836)
2011
25
Acute respiratory failure due to unilateral dorsolateral bulbar infarction. (21778729)
2011
26
Acute respiratory failure as a first manifestation of syringomyelia. (20616943)
2010
27
Survival analysis for respiratory failure in patients with food-borne botulism. (20184431)
2010
28
Hyperglycaemia results from beta-cell dysfunction in critically ill children with respiratory and cardiovascular failure: a prospective observational study. (19245691)
2009
29
Neuromuscular disease and respiratory failure. (18644909)
2008
30
Meningoencephalitis in a child complicated by myocarditis, quadriparesis and respiratory failure. (16940851)
2006
31
Acute respiratory failure due to hypokalaemic muscular paralysis from renal tubular acidosis. (16235487)
2005
32
Pulmonary sarcoidosis presenting with acute respiratory failure. (15813166)
2005
33
Failure of gamma interferon but not interleukin-10 expression in response to human papillomavirus type 11 E6 protein in respiratory papillomatosis. (15138179)
2004
34
Acute respiratory failure with gross hemoptysis in a patient with lymphangioleiomyomatosis as part of tuberous sclerosis complex. (15468981)
2004
35
Persistent respiratory insufficiency secondary to diastolic heart failure. (15042253)
2004
36
Article reviewed: Sleep-disordered breathing and respiratory failure in acid maltase deficiency. (14592241)
2002
37
Angiotensin-converting enzyme inhibitor therapy improves respiratory muscle strength in patients with heart failure. (11399702)
2001
38
Nocturnal hypoventilation in chronic respiratory failure (CRF) due to neuromuscular disease. (10893104)
2000
39
Inhaled nitric oxide in burn patients with respiratory failure. (9137249)
1997
40
Non-invasive mechanical ventilation in severe chronic obstructive lung disease and acute respiratory failure: short- and long-term prognosis. (8857115)
1996
41
Venovenous compares favorably with venoarterial access for extracorporeal membrane oxygenation in neonatal respiratory failure. (8341073)
1993
42
Neuromuscular disease, respiratory failure and cor pulmonale. (1461855)
1992
43
A serial muscle biopsy study in a case of congenital fiber-type disproportion associated with progressive respiratory failure. (2240465)
1990
44
Respiratory failure due to choriocarcinoma: a study of 103 dyspneic patients. (1696917)
1990
45
Intermittent negative pressure ventilation in the treatment of respiratory failure in progressive neuromuscular disease. (3683880)
1987
46
Respiratory failure secondary to Eaton-Lambert syndrome. (3027216)
1986
47
Delayed respiratory failure during the treatment of myxedema coma. (6532795)
1984
48
Respiratory failure in malignant histiocytosis. (7305121)
1981
49
Reversible respiratory failure due to intravascular leukostasis in chronic myelogenous leukemia. Relationship of oxygen transfer to leukocyte count. (291338)
1979
50
Respiratory failure in childhood status asthmaticus. (910761)
1977

Genetic Variations for Respiratory Failure

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Expression for genes affiliated with Respiratory Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

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37NCBI BioSystems Database
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Pathways related to Respiratory Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SERPINA1, SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Respiratory Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1lipid4411.0SERPINA1, SFTPC, SFTPD, SFTPB, SCGB1A1, GAA
2phospholipid4411.0SFTPC, SFTPD, SFTPB, SCGB1A1, ABCA7, SLC4A1
3calcium44 49 11 2413.9CCK, SFTPC, SFTPD, SFTPB, NPY, SCGB1A1
4cholesterol44 28 11 2413.9CCK, SFTPC, SFTPD, SFTPB, PIK3C2A, ABCA7
5creatinine4410.9NPY, SCGB1A1, GAA, PIK3C2A, TTN, ACTA1
6peroxynitrite4410.9SFTPC, SFTPB, SLC4A1, SERPINA1
7glucose4410.9CCK, SFTPD, NPY, GAA, PIK3C2A, SLC4A1
8tyrosine4410.9CCK, SFTPB, NPY, PIK3C2A, NKX2-1, MUSK
9chloroform4410.9PIK3C2A, SFTPB, SFTPC
10gold4410.9SFTPB, GAA, PIK3C2A, TTN
11infasurf4410.9SFTPC, SFTPB
12cysteine4410.9SFTPC, SFTPD, SFTPB, TTN, SLC4A1, SERPINA1
13dppg4410.9SFTPC, SFTPB
14popg4410.9SFTPC, SFTPB
151,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.9SFTPC, SFTPB
16acetylcholine44 49 28 11 2414.9TTN, MUSK, PIK3C2A, NPY, CCK
17[met]enkephalin4410.9CCK, NPY
18curosurf4410.9SFTPC, SFTPB
19carbohydrates4410.9GAA, NPY, SFTPD, CCK
20paraffin4410.9TSC1, SERPINA1, NKX2-1, NPY, SFTPB
21dopc4410.9SFTPC, SFTPB
22survanta4410.9SFTPC, SFTPB
23arginine4410.9CCK, SFTPC, SFTPB, NPY, GAA, PIK3C2A
24lactate4410.9SLC4A1, PIK3C2A, GAA, NPY, SFTPD
25nitric oxide44 11 2412.9SFTPD, SFTPB, NPY, SCGB1A1, SLC4A1, SERPINA1
26sucrose44 11 2412.9SFTPB, GAA, ACTA1, ALPL
27acth4410.8SERPINA1, PIK3C2A, NPY, CCK
28cyclo(his-pro)4410.8CCK, NPY
29dppc4410.8SFTPB, SFTPC
30doxycycline44 1111.8SFTPC, SFTPB, SCGB1A1
31cyclic amp44 2411.8SFTPC, SFTPD, SFTPB, NPY, NKX2-1
32octadecaneuropeptide4410.8NPY, CCK
33oxygen44 2411.8SFTPC, SFTPD, SFTPB, SCGB1A1, PIK3C2A, SERPINA1
34bicarbonate4410.8SLC4A1, PIK3C2A, CCK
35retinoic acid44 2411.8CCK, SFTPC, SFTPB, NPY, NKX2-1, ALPL
36bethanechol44 28 1112.8NPY, CCK
37progesterone44 59 28 11 2414.8SFTPB, SCGB1A1, PIK3C2A, NKX2-1, SERPINA1
38butanol4410.7SFTPC, SFTPB
39enterostatin4410.7CCK, NPY
40npff4410.7CCK, NPY
41p-opc4410.7SFTPC, SFTPB
42polysaccharide4410.7CCK, SFTPD, GAA, SERPINA1
43fibrinogen4410.7SERPINA1, PIK3C2A, SFTPB, SFTPC
44alpha msh4410.6CCK, NPY
45incretin4410.6NPY, CCK
46serine4410.6SFTPD, SFTPB, NKX2-1, TTN, ACTA1, SERPINA1
472,4-dinitrophenol4410.5NKX2-1, SFTPB
48glycogen44 2411.5TSC1, TTN, PIK3C2A, GAA
49steroid4410.4SFTPD, SCGB1A1, PIK3C2A, NKX2-1, MUSK
50sodium nitroprusside4410.2PIK3C2A, NPY, CCK

GO Terms for genes affiliated with Respiratory Failure

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16Gene Ontology
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Cellular components related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1striated muscle thin filamentGO:00586510.5ACTA1, TTN
2extracellular spaceGO:00561510.2ALPL, CCK, SFTPC, SFTPD, SFTPB, NPY

Biological processes related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:03249610.6ALPL, SERPINA1, SCGB1A1, SFTPC
2respiratory gaseous exchangeGO:00758510.5SFTPB, SFTPD, SFTPC
3regulation of protein kinase activityGO:04585910.5TSC1, TTN
4skeletal muscle thin filament assemblyGO:03024010.4TTN, ACTA1
5response to glucocorticoid stimulusGO:05138410.2ALPL, SCGB1A1, SFTPC

Molecular functions related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5TSC1, SFTPC, SFTPD, SCGB1A1, NKX2-1, IGHMBP2

Products for genes affiliated with Respiratory Failure

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  • Antibodies
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Sources for Respiratory Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet