MCID: RSP003
MIFTS: 62

Respiratory Failure malady

Respiratory diseases, Fetal diseases, Rare diseases, Infectious diseases categories

Aliases & Classifications for Respiratory Failure

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Respiratory Failure, Aliases & Descriptions:

Name: Respiratory Failure 9 11 43 32 60
Chronic Respiratory Failure 9 43 60
Acute Respiratory Failure 9 43 60
Acute-on-Chronic Respiratory Failure 9 60
Chronic Disease of Respiratory System 60
Acute and Chronic Respiratory Failure 9
 
Respiratory Insufficiency/failure 9
Chronic Respiratory Disease 43
Respiratory Tract Diseases 60
Respiratory Insufficiency 60
Respiration Disorders 60
Respiratory Disease 43


Classifications:



External Ids:

Disease Ontology9 DOID:11162
ICD9CM27 518.81
SNOMED-CT55 65710008
NCIt38 C27043

Summaries for Respiratory Failure

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MedlinePlus:32 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards based summary: Respiratory Failure, also known as chronic respiratory failure, is related to neuromuscular disease and interstitial lung disease. An important gene associated with Respiratory Failure is SFTPB (surfactant protein B), and among its related pathways are FOXA1 transcription factor network and Selected targets of C EBPalpha. The drugs oxygen and naloxone and the compounds infasurf and popg have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are muscle and tumorigenesis.

CDC:3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:63 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Related Diseases for Respiratory Failure

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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 836)
idRelated DiseaseScoreTop Affiliating Genes
1neuromuscular disease31.2GAA, TTN
2interstitial lung disease30.7SFTPD
3bronchiolitis30.7APEX1
4pneumonia30.7SCGB1A1, SFTPC, SFTPD, SFTPB
5bronchopulmonary dysplasia30.6SCGB1A1, SFTPB
6pulmonary hypertension30.6SFTPC, SFTPB
7muscular dystrophy30.5GAA, TTN
8limb-girdle muscular dystrophy30.5TTN, GAA
9congenital diaphragmatic hernia30.5SFTPB
10meconium aspiration syndrome30.4TTN, SFTPB
11polymyositis30.4GAA, TTN, SFTPD
12newborn respiratory distress syndrome30.3NKX2-1, SFTPB
13spinal muscular atrophy30.2GAA, IGHMBP2
14pulmonary alveolar proteinosis30.2SFTPC, SFTPD, SFTPB
15dermatomyositis30.2GAA, SFTPD
16duchenne muscular dystrophy30.2TTN, GAA
17motor neuron disease30.2IGHMBP2, GAA
18acute respiratory distress syndrome30.1SFTPB, SFTPD, SFTPC
19thymoma30.0TTN, NKX2-1
20pulmonary disease, chronic obstructive29.9SFTPB, SFTPD, SCGB1A1, TTN
21lung cancer29.6SFTPB, SFTPD, SCGB1A1, APEX1, NKX2-1
22pulmonary fibrosis, idiopathic29.5SFTPB, SFTPD, SFTPC, SCGB1A1
23asthma29.4SFTPB, SFTPD, SFTPC, SCGB1A1, APEX1
24cystic fibrosis29.2APEX1, SCGB1A1, SFTPC, SFTPD, SFTPB
25cork-handlers' disease28.7SFTPB, SFTPD, SFTPC, SCGB1A1, APEX1, NKX2-1
26adenocarcinoma28.7SFTPB, SFTPD, SFTPC, SCGB1A1, APEX1, NKX2-1
27neonatal respiratory failure10.8
28myopathy10.6
29status asthmaticus10.5
30influenza10.5
31sclerosing hemangioma10.5SFTPB
32muscular dystrophy, rigid spine, 110.5GAA
33myopathy, proximal, with early respiratory muscle involvement10.4
34eosinophilic pneumonia10.4
35leukemia10.4
36cor pulmonale10.4
37hypophosphatemia10.3
38botulism10.3
39obstructive lung disease10.3
40tuberculosis10.3
41distal muscular dystrophy10.3GAA, TTN
42nemaline myopathy10.3
43lambert-eaton myasthenic syndrome10.3
44myopathy congenital10.3GAA, TTN
45hypertrophic cardiomyopathy10.3TTN, GAA
46obesity10.3
47neuronopathy, distal hereditary motor, type vi10.3
48miliary tuberculosis10.3
49cervicitis10.3
50esophagitis10.3

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Symptoms for Respiratory Failure

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Drugs & Therapeutics for Respiratory Failure

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Genetic Tests for Respiratory Failure

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Anatomical Context for Respiratory Failure

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MalaCards organs/tissues related to Respiratory Failure:

31
Lung, Heart, Brain, Spinal cord, Thyroid, Kidney, Liver, Testes, Neutrophil, Skeletal muscle, Myeloid, Monocytes, Bone marrow, Bone, Breast, Skin, Placenta, T cells, Hypothalamus

Animal Models for Respiratory Failure or affiliated genes

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MGI Mouse Phenotypes related to Respiratory Failure:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.2IGHMBP2, TTN, APEX1, GAA, SLC4A1
2MP:00020068.2NKX2-1, APEX1, SCGB1A1, SFTPC
3MP:00053868.0IGHMBP2, SFTPB, SFTPC, TTN, NKX2-1, GAA
4MP:00053887.7IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, NKX2-1
5MP:00053857.3IGHMBP2, SFTPC, TTN, APEX1, NKX2-1, GAA
6MP:00053877.0SFTPD, SFTPC, SCGB1A1, TTN, APEX1, SLC4A1
7MP:00053766.5IGHMBP2, SFTPB, SFTPD, SCGB1A1, TTN, APEX1
8MP:00053786.3SLC4A1, IGHMBP2, SFTPD, SFTPC, SCGB1A1, TTN
9MP:00107686.3IGHMBP2, SFTPB, SFTPD, SFTPC, SCGB1A1, TTN

Publications for Respiratory Failure

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Articles related to Respiratory Failure:

(show top 50)    (show all 984)
idTitleAuthorsYear
1
Point-of-care ultrasound of the diaphragm in a liver transplant patient with acute respiratory failure. (25859317)
2015
2
An International Survey on Noninvasive Ventilation Use for Acute Respiratory Failure in General Non-Monitored Wards. (25406347)
2014
3
Intravenous colistin-induced acute respiratory failure: A case report and a review of literature. (25337492)
2014
4
Viral pneumonia in severe respiratory failure. (24602995)
2014
5
A 27-year-old woman presenting with refractory hypoxaemic respiratory failure, haemoptysis and thyrotoxicosis: a rare manifestation of propylthiouracil therapy. (25150234)
2014
6
Acetazolamide improves oxygenation in patients with respiratory failure and metabolic alkalosis. (23578004)
2013
7
Primary respiratory failure due to inclusion body myositis: think outside the box. (23589953)
2013
8
Respiratory failure in a mouse model of myotonic dystrophy does not correlate with the CTG repeat length. (23811192)
2013
9
Non-invasive ventilation for acute hypoxemic respiratory failure: intubation rate and risk factors. (24215648)
2013
10
Should high-dose steroid therapy and inhaled nitric oxide be considered for adult patients with H1N1 respiratory failure? (23476736)
2013
11
Epidemiology and outcomes of acute respiratory failure in the United States, 2001 to 2009: a national survey. (23335231)
2013
12
Acute respiratory failure in a rapidly enlarging benign cervical goitre. (23878293)
2013
13
A patient with severe respiratory failure caused by novel human coronavirus. (23900771)
2013
14
Extracorporeal membrane oxygenation as treatment for acute respiratory failure and subsequent pneumothorax caused by Pneumocystis jirovecii pneumonia in a kidney transplant recipient. (23279741)
2013
15
Clinical review: Early treatment of acute lung injury - paradigm shift toward prevention and treatment prior to respiratory failure. (22713281)
2012
16
State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure. (23134246)
2012
17
Efficacy of intraoperative, single-bolus corticosteroid administration to prevent postoperative acute respiratory failure after oesophageal cancer surgery. (22745302)
2012
18
The pulmonary circulation in neonatal respiratory failure. (22954275)
2012
19
Noninvasive positive pressure ventilation for chronic respiratory failure patients with stable chronic obstructive pulmonary disease (COPD): an evidence-based analysis. (23074437)
2012
20
A middle aged man with respiratory failure and weakness. (22772940)
2012
21
Race and respiratory failure: we need to learn more. (22511158)
2012
22
Single site venovenous extracorporeal membrane oxygenation as an alternative to invasive ventilation in post-pneumonectomy fistula with acute respiratory failure. (22219410)
2012
23
Acute management of neonatal respiratory failure due to crossed ectopic obstructed megaureter in a duplicated pelvic kidney. (21050823)
2011
24
Rhizomelic chondrodysplasia punctata type 1 and fulminant neonatal respiratory failure, a case report and discussion of pathophysiology. (22052861)
2011
25
Noninvasive ventilation for acute respiratory failure in patients with hematologic malignancies: what an Italian 5-year multicenter survey tells us. (21926491)
2011
26
Non-invasive ventilation for surgical patients with acute respiratory failure. (22066065)
2011
27
Altered surfactant homeostasis and recurrent respiratory failure secondary to TTF-1 nuclear targeting defect. (21867529)
2011
28
Significance of herpesvirus 6 in BAL fluid of hematology patients with acute respiratory failure. (21538037)
2011
29
Plasma orexin-a levels in COPD patients with hypercapnic respiratory failure. (21765621)
2011
30
Outcomes using extracorporeal life support for adult respiratory failure due to status asthmaticus. (19092662)
2009
31
Adjunctive pharmacotherapy in neonates with respiratory failure. (18851933)
2009
32
Bilateral pulmonary contusion, flail chest and respiratory failure on late iatrogenic diaphragmatic eventration and severe kyphoskoliosis: a case report. (19040741)
2008
33
Interleukin-1 receptor antagonist intron 2 variable number of tandem repeats polymorphism and respiratory failure in children with community-acquired pneumonia. (18838927)
2008
34
Acute respiratory failure in a 16-yr-old girl with alveolar soft part sarcoma]. (19469095)
2008
35
Neonatal respiratory failure: a 12-month clinical epidemiologic study from 2004 to 2005 in China. (18450855)
2008
36
Nephrogenic fibrosing dermopathy/nephrogenic systemic fibrosis with diaphragmatic involvement in a patient with respiratory failure. (16427988)
2006
37
Utility of B-type natriuretic peptide and N-terminal pro B-type natriuretic peptide in evaluation of respiratory failure in critically ill patients. (16002948)
2005
38
Erythropoietin response after correction of severe hypoxaemia due to acute respiratory failure in chronic obstructive pulmonary disease patients. (12917010)
2004
39
Respiratory failure due to pharyngeal dysfunction: a singular presentation of brainstem listeriosis. (12528037)
2003
40
Acute neonatal respiratory failure and Chlamydia trachomatis. (11287694)
2001
41
Opioid peptides attenuate blood pressure increase in acute respiratory failure. (11311734)
2001
42
Elevated plasma brain natriuretic peptide levels in chronic respiratory failure with cor pulmonale. (10464838)
1999
43
Intratracheal pulmonary ventilation in neonatal respiratory failure. (9934880)
1999
44
Engraftment syndrome and survival after respiratory failure post-bone marrow transplantation. (9722046)
1998
45
Respiratory failure in nemaline myopathy. (9744641)
1998
46
Respiratory failure following oral administration of metoclopramide. (9793592)
1998
47
Evaluation and treatment of respiratory failure in neuromuscular disease. (9156393)
1997
48
Domiciliary nocturnal nasal intermittent positive pressure ventilation in hypercapnic respiratory failure due to chronic obstructive lung disease: effects on sleep and quality of life. (1609376)
1992
49
Extracorporeal membrane oxygenation in neonatal respiratory failure. A brief overview. (2681581)
1989
50
Effect of hypophosphatemia on diaphragmatic contractility in patients with acute respiratory failure. (3860734)
1985

Variations for Respiratory Failure

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Expression for genes affiliated with Respiratory Failure

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Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

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Pathways related to Respiratory Failure according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
FOXA transcription factor networks36
9.3SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

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Sources:
43Novoseek, 24HMDB, 12DrugBank, 28IUPHAR, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Respiratory Failure according to GeneCards Suite gene sharing:

(show all 48)
idCompoundScoreTop Affiliating Genes
1infasurf4310.1SFTPC, SFTPB
2popg4310.1SFTPB, SFTPC
31,2-dipalmitoyl-sn-glycero-3-phosphocholine4310.1SFTPB, SFTPC
4dppg4310.1SFTPB, SFTPC
5curosurf4310.1SFTPC, SFTPB
62,4-dinitrophenol4310.1NKX2-1, SFTPB
7survanta4310.1SFTPB, SFTPC
8dopc4310.1SFTPB, SFTPC
9dppc4310.1SFTPC, SFTPB
10p-opc4310.0SFTPB, SFTPC
11butanol4310.0SFTPB, SFTPC
12chloroform4310.0SFTPC, SFTPB
13ozone4310.0SFTPB, SCGB1A1
14gold439.9GAA, TTN, SFTPB
15methanol43 2410.9SFTPC, SFTPB
16maltose43 1210.8SFTPD, GAA
17isoleucine439.8SFTPC, SFTPB
18peroxynitrite439.7SLC4A1, SFTPC, SFTPB
19doxycycline43 1210.6SFTPB, SFTPC, SCGB1A1
20mannose439.5SFTPD, GAA, SLC4A1
21ribonucleic acid439.5SFTPB, SFTPC, NKX2-1
22fatty acid439.4SFTPB, SFTPC, GAA
23phosphatidylcholine439.4SFTPC, SFTPD, SFTPB
24hydrogen43 2410.4SFTPB, SFTPC, TTN, SLC4A1
25polyacrylamide439.3SFTPB, TTN, APEX1
26creatinine439.3GAA, TTN, SCGB1A1
27lysine439.3SLC4A1, TTN, SFTPC
28bleomycin43 1210.2SFTPB, SFTPC, APEX1
29anti-fungal439.2SFTPD, APEX1
30potassium43 24 1211.2SLC4A1, APEX1, TTN
31threonine439.2NKX2-1, TTN, SFTPC, SFTPB
32paraffin439.1NKX2-1, APEX1, SFTPB
33leucine439.0SFTPB, SFTPD, SFTPC, SLC4A1
34lactate439.0SFTPD, GAA, SLC4A1
35cholesterol43 28 24 1212.0SLC4A1, SFTPC, SFTPD, SFTPB
36cyclic amp43 249.9NKX2-1, SFTPC, SFTPD, SFTPB
37atp43 289.9SLC4A1, APEX1, TTN, SFTPB
38thymidine43 249.9GAA, SFTPD, SFTPB
39dexamethasone43 49 28 1211.9NKX2-1, SFTPC, SFTPD, SFTPB
40chloramphenicol43 2 49 1211.7SFTPB, SFTPC, SCGB1A1, APEX1
41phospholipid438.6SLC4A1, SCGB1A1, SFTPC, SFTPD, SFTPB
42glucose438.5SFTPD, APEX1, GAA, SLC4A1
43nitric oxide43 24 1210.3SLC4A1, APEX1, SCGB1A1, SFTPD, SFTPB
44serine438.2SFTPB, SFTPD, TTN, APEX1, NKX2-1
45lipid438.2SFTPB, SFTPD, SFTPC, SCGB1A1, GAA, SLC4A1
46oxygen43 249.1SFTPB, SFTPD, SFTPC, SCGB1A1, APEX1
47cysteine438.0SFTPB, SFTPD, SFTPC, TTN, APEX1, SLC4A1
48calcium43 49 24 1210.7SFTPB, SFTPD, SFTPC, SCGB1A1, TTN, APEX1

GO Terms for genes affiliated with Respiratory Failure

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Cellular components related to Respiratory Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lysosomeGO:00057648.9GAA, SFTPD, SFTPB
2extracellular spaceGO:00056158.5SCGB1A1, SFTPC, SFTPD, SFTPB

Biological processes related to Respiratory Failure according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1cardiac muscle contractionGO:00600489.8TTN, GAA
2locomotory behaviorGO:00076269.7GAA, NKX2-1
3negative regulation of T cell proliferationGO:00421309.4SCGB1A1, SFTPD
4response to glucocorticoidGO:00513849.3SCGB1A1, SFTPC
5regulation of mRNA stabilityGO:00434889.2APEX1, SCGB1A1
6respiratory gaseous exchangeGO:00075859.2SFTPC, SFTPD, SFTPB
7DNA recombinationGO:00063108.9APEX1, IGHMBP2

Molecular functions related to Respiratory Failure according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00055156.4SLC4A1, NKX2-1, APEX1, TTN, SCGB1A1, SFTPC

Products for genes affiliated with Respiratory Failure

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  • Antibodies
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Sources for Respiratory Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet