MCID: RSP003
MIFTS: 70

Respiratory Failure malady

Respiratory diseases, Fetal diseases categories

Summaries for Respiratory Failure

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33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Respiratory failure happens when not enough oxygen passes from your lungs into your blood. your body's organs, such as your heart and brain, need oxygen-rich blood to work well. respiratory failure also can happen if your lungs can't remove carbon dioxide (a waste gas) from your blood. too much carbon dioxide in your blood can harm your body's organs. diseases and conditions that affect your breathing can cause respiratory failure. examples include lung diseases such as copd (chronic obstructive pulmonary disease), pneumonia, pulmonary embolism, and cystic fibrosis conditions that affect the nerves and muscles that control breathing, such as spinal cord injuries, muscular dystrophy and stroke damage to the tissues and ribs around the lungs. an injury to the chest can cause this damage. drug or alcohol overdose injuries from inhaling smoke or harmful fumes treatment for respiratory failure depends on whether the condition is acute (short-term) or chronic (ongoing) and how severe it is. it also depends on the underlying cause. you may receive oxygen therapy and other treatment to help you breathe. nih: national heart, lung, and blood institute

MalaCards: Respiratory Failure, also known as chronic respiratory failure, is related to pneumonia and myopathy. An important gene associated with Respiratory Failure is ECEL1 (endothelin converting enzyme-like 1), and among its related pathways is FOXA1 transcription factor network. The drugs naloxone and nalmefene and the compounds lipid and phospholipid have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotypes are homeostasis/metabolism and growth/size.

CDC:3 Respirators protect the user in two basic ways. The first is by the removal of contaminants from the air. Respirators of this type include particulate respirators, which filter out airborne particles; and "gas masks” which filter out chemicals and gases. Other respirators protect by supplying clean respirable air from another source. Respirators that fall into this category include airline respirators, which use compressed air from a remote source; and self-contained breathing apparatus (SCBA), which include their own air supply.

Wikipedia:63 Respiratory failure is inadequate gas exchange by the respiratory system, with the result that levels of... more...

Aliases & Classifications for Respiratory Failure

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Related Diseases for Respiratory Failure

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17GeneCards, 18GeneDecks
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Diseases in the Respiratory Failure family:

Severe Acute Respiratory Syndrome

Diseases related to Respiratory Failure via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 642)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.9SFTPC, SFTPD, SFTPB, SCGB1A1, PIK3C2A, SERPINA1
2myopathy30.7GAA, PIK3C2A, TTN, ACTA1
3neuromuscular disease30.7GAA, MUSK, TTN, ACTA1
4hypertension30.5NPY
5leukemia30.5ALPL, MUSK, SCGB1A1
6lung cancer30.3SFTPC, SFTPB, SCGB1A1, NKX2-1
7muscular dystrophy30.2LOC619409, GAA, PIK3C2A, MUSK, TTN
8interstitial lung disease30.1SFTPD
9pulmonary alveolar proteinosis30.1SFTPB, SFTPD, SFTPC
10pneumothorax30.1TSC1
11bronchiolitis obliterans30.1SCGB1A1
12diarrhea30.0ALPL
13cystic fibrosis30.0SFTPC, SFTPD, SFTPB, SCGB1A1, SERPINA1
14dermatomyositis30.0PIK3C2A, GAA, SFTPD
15dilated cardiomyopathy30.0TTN, PIK3C2A
16pancreatitis30.0ALPL, SERPINA1, CCK
17adult respiratory distress syndrome30.0SFTPB, SERPINA1
18idiopathic pulmonary fibrosis29.9SCGB1A1, SFTPB, SFTPD, SFTPC
19pulmonary disease, chronic obstructive29.9SERPINA1, SFTPD
20cork-handlers' disease29.8SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1, SERPINA1
21lung adenocarcinoma29.8CCK, SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1
22polymyositis29.8TTN, PIK3C2A, GAA, SFTPD
23adenocarcinoma29.8CCK, SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1
24congenital diaphragmatic hernia29.8SFTPB
25meconium aspiration syndrome29.8TTN, SFTPB
26dementia29.8PIK3C2A
27hepatitis29.8SERPINA1
28pulmonary fibrosis29.8SFTPD, SFTPC
29thymoma29.8NKX2-1, MUSK, TTN
30breast cancer29.8SCGB1A1, SERPINA1, TSC1, ALPL
31bronchopulmonary dysplasia29.6SFTPB, SCGB1A1
32neonatal respiratory failure10.9
33hereditary myopathy with early respiratory failure10.6
34status asthmaticus10.5
35influenza10.5
36eosinophilic pneumonia10.4
37botulism10.3
38hypophosphatemia10.3
39obstructive lung disease10.3
40tuberculosis10.3
41rhinotracheitis10.3
42nemaline myopathy10.3
43lambert-eaton myasthenic syndrome10.3
44miliary tuberculosis10.2
45acute leukemia10.2
46cervicitis10.2
47esophagitis10.2
48neuropathy10.2
49polyneuropathy10.2
50bronchiolitis10.2

Graphical network of the top 20 diseases related to Respiratory Failure:



Diseases related to respiratory failure

Clinical Features for Respiratory Failure

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Drugs & Therapeutics for Respiratory Failure

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Respiratory Failure

Drug clinical trials:

Search ClinicalTrials for Respiratory Failure

Search NIH Clinical Center for Respiratory Failure

Search CenterWatch for Respiratory Failure

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Respiratory Failure

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Anatomical Context for Respiratory Failure

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32MalaCards
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MalaCards organs/tissues related to Respiratory Failure:

32
Lung, Heart, Brain, Spinal cord, Liver, Thyroid, Kidney, Testes, Myeloid, Skeletal muscle, T cells, Monocytes, Placenta, Bone marrow, Breast, Skin, Bone, Hypothalamus

Animal Models for Respiratory Failure or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Respiratory Failure:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537610.7ALPL, CCK, NPY, SCGB1A1, GAA, PIK3C2A
2MP:000537810.7PIK3C2A, GAA, SCGB1A1, NPY, SFTPD, SFTPC
3MP:000538810.7SFTPC, SFTPD, SFTPB, SCGB1A1, NKX2-1, IGHMBP2
4MP:001076810.7NKX2-1, PIK3C2A, SCGB1A1, SFTPB, SFTPD, SFTPC
5MP:000536910.6GAA, IGHMBP2, ECEL1, MUSK, TTN, SLC4A1
6MP:000538610.6SFTPC, SFTPB, NPY, GAA, NKX2-1, IGHMBP2
7MP:000539010.5NPY, GAA, NKX2-1, ECEL1, MUSK, TTN
8MP:000537510.5ALPL, ACTA1, ABCA7, PIK3C2A, NPY
9MP:000538510.4SFTPC, GAA, NKX2-1, IGHMBP2, ECEL1, TTN
10MP:000536710.2NPY, SCGB1A1, PIK3C2A, ABCA7, SLC4A1, TSC1

Publications for Respiratory Failure

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Sources:
50PubMed
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Articles related to Respiratory Failure:

(show top 50)    (show all 971)
idTitleAuthorsYear
1
Acute respiratory failure. (23537670)
2013
2
Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure. (22826046)
2013
3
Early malperfusion, ischemia reperfusion injury, and respiratory failure in acute complicated type B aortic dissection after thoracic endovascular repair. (23342986)
2013
4
Acute respiratory failure secondary to mesalamine-induced interstitial pneumonitis. (23964037)
2013
5
Deletion of STK40 protein in mice causes respiratory failure and death at birth. (23293024)
2013
6
Effects of Early Inhaled Nitric Oxide Therapy and Vitamin A Supplementation on the Risk for Bronchopulmonary Dysplasia in Premature Newborns with Respiratory Failure. (24388327)
2013
7
Outcome of lung cancer patients admitted to the intensive care unit with acute respiratory failure. (23935346)
2013
8
Venovenous extracorporeal membrane oxygenation is effective against post-cardiotomy acute respiratory failure in adults. (23436039)
2013
9
Endobronchial valve placement for a giant bulla in a patient with hypercapnic respiratory failure. (24161057)
2013
10
Acute respiratory failure caused by phenytoin overdose. (24307853)
2013
11
Randomized controlled trial of exercise training in chronic respiratory failure due to kyphoscoliosis. (23983272)
2013
12
Manual ventilation therapy and aggressive potassium supplementation in the management of respiratory failure secondary to severe hypokalaemia in a cat with exocrine pancreatic insufficiency. (24065706)
2013
13
Successful treatment of neonatal respiratory failure caused by a novel surfactant protein C p.Cys121Gly mutation with hydroxychloroquine. (23719253)
2013
14
A middle aged man with respiratory failure and weakness. (22772940)
2012
15
Acute respiratory failure from pulmonary tuberculosis due to head trauma immunosupression. (22417046)
2012
16
Expiratory flow-volume loop profile and patient outcome in chronic obstructive pulmonary disease in acute respiratory failure: a prospective observational study in a single intensive care unit. (21986039)
2012
17
Trends in and perspectives on extracorporeal membrane oxygenation for severe adult respiratory failure. (22451141)
2012
18
On a case of respiratory failure due to diaphragmatic paralysis and dilated cardiomyopathy in a patient with nemaline myopathy. (23620652)
2012
19
Venovenous extracorporeal membrane oxygenation in acute respiratory failure: do we need a new configuration? (22424528)
2012
20
Early out-of-hospital non-invasive ventilation is superior to standard medical treatment in patients with acute respiratory failure: a pilot study. (21951764)
2012
21
Transient defect in nitric oxide generation after rupture of fetal membranes and responsiveness to inhaled nitric oxide in very preterm infants with hypoxic respiratory failure. (22554621)
2012
22
Noninvasive mechanical ventilation for prevention of post-extubation respiratory failure. (22867647)
2012
23
Variation in academic medical centers' coding practices for postoperative respiratory complications: implications for the AHRQ postoperative respiratory failure Patient Safety Indicator. (22643197)
2012
24
Contemporary extracorporeal membrane oxygenation for adult respiratory failure: life support in the new era. (22147116)
2012
25
Acute respiratory failure and intensive measures. (22920463)
2012
26
Risk factors of respiratory failure in children with Guillain-BarrAc syndrome. (23084721)
2012
27
Management of kyphoscoliosis patients with respiratory failure in the intensive care unit and during long term follow up. (22999093)
2012
28
Postoperative pulmonary complications: pneumonia and acute respiratory failure. (22414416)
2012
29
Assessment of some inflammatory biomarkers as predictors of outcome of acute respiratory failure on top of chronic obstructive pulmonary disease and evaluation of the role of bacteria. (23724320)
2012
30
Resolution of chylous pulmonary congestion and respiratory failure in lymphangioleiomyomatosis with sirolimus therapy. (22896596)
2012
31
Pre-operative risk factors predict post-operative respiratory failure after liver transplantation. (21829646)
2011
32
Noninvasive ventilation in acute respiratory failure due to H1N1 influenza: A word of caution. (21712932)
2011
33
The effect of sivelestat sodium hydrate on severe respiratory failure after thoracic aortic surgery with deep hypothermia. (21881324)
2011
34
Respiratory failure was improved by growth hormone substitution in a patient with hypopituitarism. (22766570)
2010
35
Bilateral pulmonary contusion, flail chest and respiratory failure on late iatrogenic diaphragmatic eventration and severe kyphoskoliosis: a case report. (19040741)
2008
36
Noninvasive Positive-Pressure Ventilation for Acute Respiratory Failure: Comparative Effectiveness (23136672)
2007
37
Acute respiratory failure in adult patients with dengue virus infection. (17620647)
2007
38
Virus associated hemophagocytic syndrome accompanied by acute respiratory failure caused by influenza A (H3N2). (17106167)
2006
39
Very long-chain acyl-CoA dehydrogenase deficiency presenting as acute hypercapnic respiratory failure. (16880373)
2006
40
Acute respiratory failure and tracheal obstruction in patients with posterior giant mediastinal (intrathoracic) goiter. (17670208)
2004
41
Respiratory failure associated with the lipodystrophy syndrome in an HIV-positive patient with compromised lung function. (11521144)
2001
42
Deletion of NKX2.1 gene encoding thyroid transcription factor-1 in two siblings with hypothyroidism and respiratory failure. (10931427)
2000
43
Multifocal motor neuropathy presenting with respiratory failure. (11102916)
2000
44
Intratracheal pulmonary ventilation in neonatal respiratory failure. (9934880)
1999
45
Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice. (7644495)
1995
46
Extra corporeal membrane oxygenation (ECMO) for neonatal respiratory failure. (2131304)
1990
47
High-frequency oscillatory ventilation and extracorporeal membrane oxygenation for the treatment of acute neonatal respiratory failure. (2296503)
1990
48
Postoperative respiratory failure due to acute eosinophilic pneumonia. (2246425)
1990
49
Acute life threatening respiratory failure due to multinodular goiter. (6838062)
1983
50
Failure to thrive secondary to upper respiratory tract obstruction and cor pulmonale. (7086384)
1982

Genetic Variations for Respiratory Failure

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Expression for genes affiliated with Respiratory Failure

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Respiratory Failure

Search GEO for disease gene expression data for Respiratory Failure.

Pathways for genes affiliated with Respiratory Failure

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37NCBI BioSystems Database
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Pathways related to Respiratory Failure according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5SERPINA1, SCGB1A1, SFTPD

Compounds for genes affiliated with Respiratory Failure

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Respiratory Failure according to GeneCards/GeneDecks:

(show top 50)    (show all 51)
idCompoundScoreTop Affiliating Genes
1lipid4411.0SERPINA1, SFTPC, SFTPD, SFTPB, SCGB1A1, GAA
2phospholipid4411.0SFTPC, SFTPD, SFTPB, SCGB1A1, ABCA7, SLC4A1
3calcium44 49 11 2413.9CCK, SFTPC, SFTPD, SFTPB, NPY, SCGB1A1
4cholesterol44 28 11 2413.9CCK, SFTPC, SFTPD, SFTPB, PIK3C2A, ABCA7
5creatinine4410.9NPY, SCGB1A1, GAA, PIK3C2A, TTN, ACTA1
6peroxynitrite4410.9SFTPC, SFTPB, SLC4A1, SERPINA1
7glucose4410.9CCK, SFTPD, NPY, GAA, PIK3C2A, SLC4A1
8tyrosine4410.9CCK, SFTPB, NPY, PIK3C2A, NKX2-1, MUSK
9chloroform4410.9PIK3C2A, SFTPB, SFTPC
10gold4410.9SFTPB, GAA, PIK3C2A, TTN
11infasurf4410.9SFTPC, SFTPB
12cysteine4410.9SFTPC, SFTPD, SFTPB, TTN, SLC4A1, SERPINA1
13dppg4410.9SFTPC, SFTPB
14popg4410.9SFTPC, SFTPB
151,2-dipalmitoyl-sn-glycero-3-phosphocholine4410.9SFTPC, SFTPB
16acetylcholine44 49 28 11 2414.9TTN, MUSK, PIK3C2A, NPY, CCK
17[met]enkephalin4410.9CCK, NPY
18curosurf4410.9SFTPC, SFTPB
19carbohydrates4410.9GAA, NPY, SFTPD, CCK
20paraffin4410.9TSC1, SERPINA1, NKX2-1, NPY, SFTPB
21dopc4410.9SFTPC, SFTPB
22survanta4410.9SFTPC, SFTPB
23arginine4410.9CCK, SFTPC, SFTPB, NPY, GAA, PIK3C2A
24lactate4410.9SLC4A1, PIK3C2A, GAA, NPY, SFTPD
25nitric oxide44 11 2412.9SFTPD, SFTPB, NPY, SCGB1A1, SLC4A1, SERPINA1
26sucrose44 11 2412.9SFTPB, GAA, ACTA1, ALPL
27acth4410.8SERPINA1, PIK3C2A, NPY, CCK
28cyclo(his-pro)4410.8CCK, NPY
29dppc4410.8SFTPB, SFTPC
30doxycycline44 1111.8SFTPC, SFTPB, SCGB1A1
31cyclic amp44 2411.8SFTPC, SFTPD, SFTPB, NPY, NKX2-1
32octadecaneuropeptide4410.8NPY, CCK
33oxygen44 2411.8SFTPC, SFTPD, SFTPB, SCGB1A1, PIK3C2A, SERPINA1
34bicarbonate4410.8SLC4A1, PIK3C2A, CCK
35retinoic acid44 2411.8CCK, SFTPC, SFTPB, NPY, NKX2-1, ALPL
36bethanechol44 28 1112.8NPY, CCK
37progesterone44 59 28 11 2414.8SFTPB, SCGB1A1, PIK3C2A, NKX2-1, SERPINA1
38butanol4410.7SFTPC, SFTPB
39enterostatin4410.7CCK, NPY
40npff4410.7CCK, NPY
41p-opc4410.7SFTPC, SFTPB
42polysaccharide4410.7CCK, SFTPD, GAA, SERPINA1
43fibrinogen4410.7SERPINA1, PIK3C2A, SFTPB, SFTPC
44alpha msh4410.6CCK, NPY
45incretin4410.6NPY, CCK
46serine4410.6SFTPD, SFTPB, NKX2-1, TTN, ACTA1, SERPINA1
472,4-dinitrophenol4410.5NKX2-1, SFTPB
48glycogen44 2411.5TSC1, TTN, PIK3C2A, GAA
49steroid4410.4SFTPD, SCGB1A1, PIK3C2A, NKX2-1, MUSK
50sodium nitroprusside4410.2PIK3C2A, NPY, CCK

GO Terms for genes affiliated with Respiratory Failure

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Sources:
16Gene Ontology
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Cellular components related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1striated muscle thin filamentGO:00586510.5ACTA1, TTN
2extracellular spaceGO:00561510.2ALPL, CCK, SFTPC, SFTPD, SFTPB, NPY

Biological processes related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:03249610.6SCGB1A1, SFTPC, SERPINA1, ALPL
2respiratory gaseous exchangeGO:00758510.5SFTPB, SFTPC, SFTPD
3regulation of protein kinase activityGO:04585910.5TSC1, TTN
4skeletal muscle thin filament assemblyGO:03024010.4TTN, ACTA1
5response to glucocorticoid stimulusGO:05138410.2ALPL, SCGB1A1, SFTPC

Molecular functions related to Respiratory Failure according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551510.5TSC1, SFTPC, SFTPD, SCGB1A1, NKX2-1, IGHMBP2

Products for genes affiliated with Respiratory Failure

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  • Antibodies
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Sources for Respiratory Failure

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet