Restless Legs Syndrome (RLS) malady

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Disease Ontology11 DOID:0050425 ICD1030 G25.81 ICD9CM32 333.94 SNOMED-CT62 32914008, 393579008

MeSH39 D012148 NCIt45 C84501 UMLS68 C0035258

NIH Rare Diseases:⁴⁸ Restless legs syndrome (rls) is a neurological condition that causes an irresistible urge to move the legs. the movement is triggered by strange or uncomfortable feelings, which occur mostly while the affected person is sitting or lying down and are worse at night. movement (i.e. kicking, stretching, rubbing, or pacing) makes the discomfort go away, at least temporarily. many people with restless legs syndrome also have uncontrollable, repetitive leg movements that occur while they are sleeping or while relaxed or drowsy. researchers have described early-onset and late-onset forms of restless legs syndrome. the early-onset form begins before age 45 and progresses slowly. the late-onset form begins after age 45, and its signs and symptoms tend to worsen more rapidly. rls likely results from a combination of genetic and environmental factors, many of which are unknown. the syndrome may also be classified in several types (rls1, rls2, rls3, rls4, rls5, rls6, rls7) according to the location in specific chromosomes of some of the genes that are associated with an increased risk (susceptibility) to have the syndrome.  treatment is based on the signs and symptoms present in each person. last updated: 5/5/2017

MalaCards based summary: Restless Legs Syndrome, also known as restless leg syndrome, is related to restless legs syndrome 2 and restless legs syndrome 6, and has symptoms including back pain, headache and pain. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB Domain Containing 9), and among its related pathways are Iron metabolism in placenta and DARPP-32 Phosphorylation. The drugs carbamazepine and clonazepam have been mentioned in the context of this disorder. Affiliated tissues include lung, heart and brain, and related mouse phenotype nervous system.

Disease Ontology:¹¹ A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.

Genetics Home Reference:²⁵ Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

MedlinePlus:³⁸ Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

NINDS:⁴⁹ Restless legs syndrome (RLS) is characterized by unpleasant sensations in the legs and an irresistible urge to move them. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful. Symptoms commonly occur in late afternoon or evening and are most severe at night, when the person is resting. Moving the legs or walking typically relieves the discomfort but the symptoms often recur. RLS is both a sleep and a neurological sensory disorder.

Wikipedia:⁷¹ Restless legs syndrome (RLS) is a disorder that causes a strong urge to move one\'s legs. There is often... more...

MGI Mouse Phenotypes related to Restless Legs Syndrome according to GeneCards Suite gene sharing:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	6.9	ATXN3, BTBD9, DRD2, DRD3, HCRT, SLC11A2

Search GEO for disease gene expression data for Restless Legs Syndrome.