RLS
MCID: RST001
MIFTS: 56

Restless Legs Syndrome (RLS) malady

Summaries for Restless Legs Syndrome

About this section
Sources:
21Genetics Home Reference, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards: Restless Legs Syndrome, also known as restless legs syndrome, susceptibility to, 1, is related to parkinson's disease and migraine. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and Dopamine receptors. The drugs carbamazepine and clonazepam and the compounds nmda and talipexole have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotype nervous system.

Genetics Home Reference:21 Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

NINDS:43 Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Wikipedia:63 Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Aliases & Classifications for Restless Legs Syndrome

About this section
Sources:
8Disease Ontology, 21Genetics Home Reference, 43NINDS, 44Novoseek, 60UMLS, 33MedlinePlus, 34MeSH
See all sources

Aliases & Descriptions:

restless legs syndrome 8 21 43 44 60
restless legs syndrome, susceptibility to, 1 60
restless leg syndrome 21
willis-ekbom disease 21
ekbom's syndrome 21
ekbom syndrome 21
restless legs 33
wed 21
rls 21


External Ids:

Disease Ontology8 DOID:0050425
MeSH34 D012148

Related Diseases for Restless Legs Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Restless Legs Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.2MAOB, NTS, DRD3, DRD2
2migraine31.0HCRT, MAOB, DRD3, DRD2, DRD1
3multiple sclerosis30.9HCRT, TFRC, DRD2
4attention deficit hyperactivity disorder30.8MAOB, DRD2, DRD1
5narcolepsy30.7DRD1, DRD2, ATXN3, HCRT
6pathological gambling30.5DRD3, DRD2, DRD1
7schizophrenia30.5DRD1, DRD2, DRD3, NTS, MAOB, HCRT
8amyotrophic lateral sclerosis30.4MAOB, TFRC
9alzheimer's disease30.2HCRT, MAOB, NTS, DRD3, DRD2, DRD1
10periodic limb movement disorder10.9
11sleep disorder10.8
12neuropathy10.7
13adult syndrome10.6
14image syndrome10.5
15kidney disease10.5
16restless legs syndrome, susceptibility to, 210.5
17essential tremor10.4
18irritable bowel syndrome10.4
19charcot-marie-tooth disease10.4
20diabetic neuropathy10.4
21hypertension10.4
22tooth disease10.4
23restless legs syndrome, susceptibility to, 110.4
24restless legs syndrome, susceptibility to, 310.4
25restless legs syndrome, susceptibility to, 410.4
26restless legs syndrome, susceptibility to, 510.4
27bruxism10.4
28cerebrovascular disease10.4
29impulse control disorder10.4
30migraine with aura10.4
31vascular disease10.4
32spinocerebellar ataxia type 310.4
33restless legs syndrome, susceptibility to, 610.4
34deficiency anemia10.3
35axonal neuropathy10.3
36major depressive disorder10.3
37lateral sclerosis10.3
38charcot-marie-tooth disease type 210.3
39iron deficiency anemia10.3
40brain disease10.3
41epilepsy syndrome10.3
42liver disease10.3
43multiple myeloma10.3
44myeloma10.3
45peripheral neuropathy10.3
46polyneuropathy10.3
47spinocerebellar ataxia10.3
48restless legs syndrome 710.3
49restless legs syndrome 810.3
50burns10.1

Graphical network of the top 20 diseases related to Restless Legs Syndrome:



Diseases related to restless legs syndrome

Clinical Features for Restless Legs Syndrome

About this section

Drugs & Therapeutics for Restless Legs Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Restless Legs Syndrome

Drug clinical trials:

Search ClinicalTrials for Restless Legs Syndrome

Search NIH Clinical Center for Restless Legs Syndrome

Search CenterWatch for Restless Legs Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Restless Legs Syndrome

About this section

Anatomical Context for Restless Legs Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Restless Legs Syndrome:

32
Heart, Lung, Brain, Kidney, Testes, Liver, Skin, Eye, Small intestine, Spinal cord, Cortex, Globus pallidus

Animal Models for Restless Legs Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Restless Legs Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.8BTBD9, DRD2, DRD3, TFRC, MEIS1, ATXN3

Publications for Restless Legs Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Restless Legs Syndrome:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Treatment of restless legs syndrome. (24363103)
2014
2
Is a diagnosis of ancillary restless legs syndrome reproducible over time? Experience with the Wayne Hening telephone diagnostic interview. (23517586)
2013
3
Effectiveness and tolerability of rotigotine transdermal patch for the treatment of restless legs syndrome in a routine clinical practice setting in Germany. (23668924)
2013
4
Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. (23390174)
2013
5
Restless legs syndrome: update on pathogenesis. (24048084)
2013
6
Topography of sensory symptoms in patients with drug-naA^ve restless legs syndrome. (24157096)
2013
7
Validation of the Multiple Suggested Immobilization Test: A Test for the Assessment of Severity of Restless Legs Syndrome (Willis-Ekbom Disease). (23814348)
2013
8
Is restless legs syndrome associated with cardiovascular disease? (23410556)
2013
9
Restless legs syndrome is underdiagnosed in the US Renal Data System. (23359721)
2013
10
Increased synaptic dopamine in the putamen in restless legs syndrome. (23288971)
2013
11
Prevalence of restless legs syndrome in patients with chronic pain in Maputo, Mozambique. (24211034)
2013
12
Restless legs syndrome and coronary artery disease risk. (23841185)
2013
13
Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep. (23624560)
2013
14
Presenting symptoms in pediatric restless legs syndrome patients. (24127152)
2013
15
Management of symptoms of Restless Legs Syndrome with use of a traction straight leg raise: a preliminary case series. (23276629)
2013
16
Restless legs syndrome in an appalachian primary care population: prevalence, demographic and lifestyle correlates, and burden. (24127151)
2013
17
Restless legs syndrome reported by incident haemodialysis patients: is treatment time of day relevant? (22713094)
2012
18
Long-term use of pramipexole in the management of restless legs syndrome. (23036265)
2012
19
Suggested immobilization test for diagnosis of restless legs syndrome in Parkinson's disease. (22437899)
2012
20
Restless legs syndrome and all-cause mortality in four prospective cohort studies. (23129573)
2012
21
Role of gabapentin enacarbil XR in restless legs syndrome. (22570552)
2012
22
Prevalence of neuroleptic-induced restless legs syndrome in patients taking neuroleptic drugs. (22099638)
2012
23
Frequency, severity and risk factors for restless legs syndrome in healthcare personnel. (22772928)
2012
24
Incremental effects of restless legs syndrome on nocturnal blood pressure in hypertensive patients and normotensive individuals. (23111555)
2012
25
Increased frequency of restless legs syndrome in atopic dermatitis. (22712855)
2012
26
Periodic leg movements during sleep in narcoleptic patients with or without restless legs syndrome. (21827556)
2012
27
Restless legs syndrome. (23169803)
2012
28
Intravenous iron given prior to pregnancy for restless legs syndrome is associated with remission of symptoms. (23066374)
2012
29
Effect of pramipexole on cutaneous-silent-period parameters in patients with restless legs syndrome. (21757401)
2012
30
Association between irritable bowel syndrome and restless legs syndrome: a comparative study with control group. (23106004)
2012
31
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. (21677899)
2011
32
Sensory profile in primary restless legs syndrome and restless legs syndrome associated with small fibre neuropathy. (21059747)
2011
33
Efficacy and augmentation during 6 months of double-blind pramipexole for restless legs syndrome. (21354368)
2011
34
Effects of STN DBS for Parkinson's disease on restless legs syndrome and other sleep-related measures. (21216651)
2011
35
A 10-year, longitudinal assessment of dopamine agonists and methadone in the treatment of restless legs syndrome. (21239226)
2011
36
Incidence of restless legs syndrome in two population-based cohort studies in Germany. (22063473)
2011
37
Prevalence and clinical characteristics of restless legs syndrome in chronic kidney disease patients. (22036105)
2011
38
Effect of the antiplatelet agent cilostazol on endovascular inflammatory biochemical parameters and the clinical symptoms of peripheral artery disease and restless legs syndrome in hemodialysis patients. (21773691)
2011
39
Restless legs syndrome in Friedreich ataxia: a polysomnographic study. (21412837)
2011
40
Restless legs syndrome in post-polio syndrome: a series of 10 patients with demographic, clinical and laboratorial findings. (21640631)
2011
41
Restless legs syndrome: literature review. (20963367)
2010
42
Restless legs syndrome and pregnancy: a questionnaire study in the Poitiers District, France. (20980760)
2010
43
Restless legs syndrome and periodic limb movements disorder in the pediatric population. (20859209)
2010
44
Effect of tetrabenazine use on restless legs syndrome. (20817597)
2010
45
The use of rotigotine in the treatment of restless legs syndrome. (21179615)
2010
46
Restless legs syndrome and Parkinson's disease in men. (20737545)
2010
47
High prevalence of restless legs syndrome in somatoform pain disorder. (16917680)
2007
48
Restless legs syndrome and periodic limb movement disorder. (15087209)
2004
49
Mutational analysis of neurotensin in familial restless legs syndrome. (14743366)
2004
50
Subjective sleep quality and suggested immobilization test in restless leg syndrome and periodic limb movement disorder. (12047601)
2002

Genetic Variations for Restless Legs Syndrome

About this section

Expression for genes affiliated with Restless Legs Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Restless Legs Syndrome

Search GEO for disease gene expression data for Restless Legs Syndrome.

Pathways for genes affiliated with Restless Legs Syndrome

About this section
Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG
See all sources

Compounds for genes affiliated with Restless Legs Syndrome

About this section
Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nmda44 2811.7TFRC, HCRT, MAOB
2talipexole4410.7DRD3, MAOB, DRD2
3eticlopride28 4411.7DRD3, DRD1, DRD2
4cis flupentixol2810.7DRD3, DRD2, DRD1
5sch 233904410.6DRD3, DRD1, DRD2
6(+)-butaclamol28 4411.6DRD3, DRD1, DRD2
7piribedil28 4411.6MAOB, DRD3, DRD2
8rotigotine44 28 1112.6DRD1, DRD3, DRD2, MAOB
9d amphetamine4410.6DRD1, DRD2, MAOB
10methylphenidate44 49 1112.6HCRT, MAOB, DRD2, DRD1
11raclopride44 2811.6DRD1, DRD2, DRD3
12sulpiride44 28 1112.6NTS, DRD1, DRD2, DRD3
13ropinirole44 1111.6DRD3, DRD1, DRD2, MAOB
14Chlorprothixene1110.6DRD3, DRD1, DRD2
15quinpirole44 2811.6DRD1, DRD3, NTS, DRD2
16spiperone28 4411.6DRD1, DRD3, DRD2
17dopac4410.6DRD1, DRD3, MAOB
18amantadine44 1111.6DRD3, MAOB, DRD2
19apomorphine44 28 1112.6DRD3, DRD2, DRD1, MAOB, NTS
20domperidone44 28 1112.6DRD1, DRD2, DRD3
21amphetamine44 1111.6MAOB, HCRT, NTS, DRD2, DRD1
22methamphetamine44 49 1112.5MAOB, DRD1, NTS, DRD3, DRD2
236-hydroxydopamine4410.5DRD1, NTS, MAOB, DRD2, DRD3
24reserpine44 28 1112.5DRD2, NTS, MAOB
25chlorpromazine44 28 49 1113.5DRD1, DRD2, DRD3, NTS
26mptp4410.5DRD3, DRD2, MAOB, DRD1
27thioridazine28 44 49 1113.5DRD2, NTS, DRD1
28olanzapine49 44 28 11 2414.5DRD1, DRD2, NTS, DRD3
29lisuride28 44 1112.5DRD3, DRD1, DRD2
30opiate4410.5NTS, DRD1, DRD2, DRD3, TF, HCRT
31pergolide28 44 1112.5DRD1, DRD2, DRD3
32catecholamine4410.5DRD1, NTS, HCRT, MAOB, DRD3
33haloperidol44 28 2 49 1114.5NTS, DRD1, DRD2, MAOB, HCRT, DRD3
34levodopa44 1111.5MAOB, NTS, TF, DRD3, DRD2, DRD1
35paliperidone44 1111.5DRD2, DRD3, DRD1
36iloperidone49 44 28 1113.5DRD2, DRD1, DRD3
37nicotine44 49 28 1113.5NTS, HCRT, DRD1, DRD3, MAOB, DRD2
38gaba4410.4DRD2, DRD1, TF, NTS, MAOB, HCRT
39Methotrimeprazine1110.4DRD2, DRD3, DRD1
40cocaine44 1111.4TF, DRD2, DRD1, NTS, MAOB, DRD3
41pramipexole44 49 28 1113.4DRD1, DRD3, DRD2
42norepinephrine44 11 2412.4TF, DRD1, HCRT, DRD3, NTS, MAOB
43dopamine44 28 11 2413.4DRD2, MAOB, NTS, TFRC, TF, DRD3
44(+)-s-142972810.3DRD2, DRD3
45clozapine44 28 49 1113.3NTS, DRD1, DRD2, DRD3
46glutamate4410.3TF, TFRC, DRD3, DRD2, NTS, MAOB
47asenapine28 1111.3DRD1, DRD3, DRD2
48epinephrine44 11 2412.2NTS, MAOB, TF, DRD2, HCRT
49cabergoline28 44 1112.2DRD3, DRD2, DRD1
50trans flupenthixol2810.0DRD3, DRD2

GO Terms for genes affiliated with Restless Legs Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:03013910.3TF, DRD3, DRD2

Biological processes related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.6DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2, DRD1
6dopamine metabolic processGO:04241710.6DRD3, DRD2, DRD1
7behavioral response to cocaineGO:04814810.6DRD1, DRD2, DRD3
8cerebral cortex GABAergic interneuron migrationGO:02185310.6DRD1, DRD2
9synaptic transmission, dopaminergicGO:00196310.6DRD1, DRD2, DRD3
10prepulse inhibitionGO:06013410.6DRD3, DRD2, DRD1
11peristalsisGO:03043210.6DRD2, DRD1
12response to amphetamineGO:00197510.6DRD1, DRD2, DRD3
13phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD2, DRD1
14regulation of dopamine secretionGO:01405910.6DRD2, DRD3
15visual learningGO:00854210.6DRD1, DRD2, DRD3
16adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
17G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2
18negative regulation of protein secretionGO:05070910.5DRD3, DRD2
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.4DRD1, DRD2
20arachidonic acid secretionGO:05048210.4DRD2, DRD3
21positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
22response to drugGO:04249310.3DRD1, DRD2, DRD3, MAOB
23temperature homeostasisGO:00165910.3DRD2, DRD1
24circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
25grooming behaviorGO:00762510.0DRD1, DRD2

Molecular functions related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD3, DRD2
2dopamine bindingGO:03524010.0DRD3, DRD2, DRD1

Products for genes affiliated with Restless Legs Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Restless Legs Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet