RLS
MCID: RST001
MIFTS: 61

Restless Legs Syndrome (RLS) malady

Neuronal diseases category
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Summaries for Restless Legs Syndrome

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MedlinePlus:33 Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards based summary: Restless Legs Syndrome, also known as willis-ekbom disease, is related to parkinson's disease and migraine. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and HIF-1-alpha transcription factor network. The drugs carbamazepine and clonazepam and the compounds saporin and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are growth/size/body and nervous system.

Disease Ontology:8 A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.

NINDS:43 Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Genetics Home Reference:21 Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

Wikipedia:65 Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Descriptions from OMIM:46 612853, 610438, 610439, 608830, 615197 611242, 611185, 102300 more

Aliases & Classifications for Restless Legs Syndrome

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Restless Legs Syndrome, Aliases & Descriptions:

Name: Restless Legs Syndrome 8 21 43 44 62
Willis-Ekbom Disease 8 21 62
Wittmaack-Ekbom Syndrome 8 62
Ekbom Syndrome 21 62
Wed 8 21
 
Restless Legs Syndrome, Susceptibility to, 1 62
Restless Leg Syndrome 21
Ekbom's Syndrome 21
Restless Legs 33
Rls 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:0050425
MeSH34 D012148
ICD9CM27 333.94

Related Diseases for Restless Legs Syndrome

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Diseases related to Restless Legs Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 156)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.4DRD2, HCRT, HTR3A
2migraine31.2HTR3A, DRD2, HCRT
3narcolepsy31.2DRD2, HCRT
4multiple sclerosis31.1HCRT, DRD2, TFRC
5iron deficiency anemia30.8TFRC, TF
6eating disorder30.6HTR3A, HCRT
7schizophrenia30.6HTR3A, HCRT, DRD2
8friedreich ataxia30.6FTMT, TFRC
9periodic limb movement disorder10.9
10blindness10.8
11neuropathy10.7
12sleep disorder10.6
13attention deficit hyperactivity disorder10.6
14kidney disease10.6
15restless legs syndrome, susceptibility to, 110.5
16restless legs syndrome, susceptibility to, 210.5
17charcot-marie-tooth disease10.5
18hypertension10.5
19irritable bowel syndrome10.5
20essential tremor10.5
21impulse control disorder10.5
22tooth disease10.5
23restless legs syndrome, susceptibility to, 310.5
24restless legs syndrome, susceptibility to, 410.5
25restless legs syndrome, susceptibility to, 510.5
26headache10.5
27tremor10.5
28neuroleptic malignant syndrome10.5DRD2
29diabetic neuropathy10.4
30bruxism10.4
31machado-joseph disease10.4
32pathological gambling10.4
33myotonic dystrophy type 210.4
34cerebrovascular disease10.4
35migraine with aura10.4
36myotonic dystrophy10.4
37restless legs syndrome, susceptibility to, 610.4
38ataxia10.4
39deficiency anemia10.3
40amyotrophic lateral sclerosis10.3
41arthritis10.3
42liver disease10.3
43multiple myeloma10.3
44rheumatoid arthritis10.3
45axonal neuropathy10.3
46lateral sclerosis10.3
47charcot-marie-tooth disease type 210.3
48pain disorder10.3
49neuronitis10.3
50artery disease10.3

Graphical network of the top 20 diseases related to Restless Legs Syndrome:



Diseases related to restless legs syndrome

Symptoms for Restless Legs Syndrome

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Clinical features from OMIM:

612853,610438,610439,608830,615197,611242,611185,102300

Drugs & Therapeutics for Restless Legs Syndrome

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Drug clinical trials:

Search ClinicalTrials for Restless Legs Syndrome

Search NIH Clinical Center for Restless Legs Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Restless Legs Syndrome

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Anatomical Context for Restless Legs Syndrome

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MalaCards organs/tissues related to Restless Legs Syndrome:

32
Heart, Lung, Brain, Kidney, Testes, Liver, Eye, Cortex, Spinal cord, Small intestine, Skin, Globus pallidus

Animal Models for Restless Legs Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Restless Legs Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1TF, TFRC, HCRT, HTR3A, DRD2
2MP:00036318.1BTBD9, DRD2, HTR3A, HCRT, TFRC
3MP:00053767.6HCRT, TF, HTR3A, DRD2, BTBD9, TFRC

Publications for Restless Legs Syndrome

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Articles related to Restless Legs Syndrome:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Changes in motor behavior during pregnancy in rats: the basis for a possible animal model of restless legs syndrome. (25295571)
2014
2
Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in Taiwan. (24433515)
2014
3
Treatment of restless legs syndrome. (23703310)
2013
4
Restless legs syndrome: impact on sleep-related breathing disorders. (22882720)
2013
5
Prevalence and associated features of restless legs syndrome in a population of Iranian women during pregnancy. (23886452)
2013
6
Is a diagnosis of ancillary restless legs syndrome reproducible over time? Experience with the Wayne Hening telephone diagnostic interview. (23517586)
2013
7
Bad medicine: restless legs syndrome. (24355578)
2013
8
Improvement of restless legs syndrome by varenicline as antismoking treatment. (24127155)
2013
9
Restless legs syndrome and quality of sleep in patients with glomerulopathy. (23710767)
2013
10
Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome. (23305102)
2013
11
Effectiveness and tolerability of rotigotine transdermal patch for the treatment of restless legs syndrome in a routine clinical practice setting in Germany. (23668924)
2013
12
Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. (23390174)
2013
13
Restlessness in right upper limb as sole presentation of restless legs syndrome. (23546363)
2013
14
Prospective study of restless legs syndrome and risk of erectile dysfunction. (23608708)
2013
15
Restless legs syndrome in patients with systemic sclerosis. Prevalence and possible causes. (23456369)
2013
16
Restless legs syndrome in a group of patients with Alzheimer's disease. (23264651)
2013
17
Restless legs syndrome: update on pathogenesis. (24048084)
2013
18
Exome sequencing in a family with restless legs syndrome. (23192925)
2012
19
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
20
Epidemiology of restless legs syndrome: a synthesis of the literature. (21795081)
2012
21
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
22
European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. (22937989)
2012
23
Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic restless legs syndrome patients. (22175823)
2012
24
Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. (22038683)
2012
25
Efficacy and safety of pramipexole in chinese patients with restless legs syndrome: results from a multi-center, randomized, double-blind, placebo-controlled trial. (22137119)
2012
26
Assessing health-related quality of life in patients with restless legs syndrome in Korea: comparison with other chronic medical diseases. (22939530)
2012
27
Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey. (21722973)
2012
28
Restless legs syndrome reported by incident haemodialysis patients: is treatment time of day relevant? (22713094)
2012
29
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. (21677899)
2011
30
Sensory profile in primary restless legs syndrome and restless legs syndrome associated with small fibre neuropathy. (21059747)
2011
31
Restless abdomen: a phenotypic variant of restless legs syndrome. (21917771)
2011
32
Psychiatric comorbidity in children and adolescents with restless legs syndrome: a retrospective study. (22171196)
2011
33
Prevalence and clinical correlates of restless legs syndrome among psychogeriatric patients. (21748800)
2011
34
Pregabalin is more effective than placebo for restless legs syndrome with mild adverse effects of daytime somnolence, headache and unsteadiness. (21081629)
2011
35
Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. (21715702)
2011
36
Restless legs syndrome mothers and attention-deficit/hyperactivity disorder children: what happened between them? (20851048)
2011
37
Migraine and restless legs syndrome: is there an association? (21660429)
2011
38
Profile of altered brain iron acquisition in restless legs syndrome. (21398376)
2011
39
No significance of the COMT val158met polymorphism in restless legs syndrome. (20184941)
2010
40
Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch. (20920156)
2010
41
Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. (20629075)
2010
42
Decision making in restless legs syndrome. (20669306)
2010
43
Prevalence and clinical profile of restless legs syndrome in Parkinson's disease. (20737549)
2010
44
Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome. (17659477)
2007
45
Reported bruxism and restless legs syndrome in media personnel with or without irregular shift work. (16134548)
2005
46
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
47
Circadian variation in neuroendocrine response to L-dopa in patients with restless legs syndrome. (15283001)
2004
48
SLEEP year in review 2003--insomnia, sleep in psychiatric disorders, periodic limb movement disorder/restless legs syndrome, sleep in medical disorders. (15532215)
2004
49
Autosomal dominant restless legs syndrome maps on chromosome 14q. (12764067)
2003
50
Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. (12136060)
2002

Variations for Restless Legs Syndrome

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Expression for genes affiliated with Restless Legs Syndrome

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Expression patterns in normal tissues for genes affiliated with Restless Legs Syndrome

Search GEO for disease gene expression data for Restless Legs Syndrome.

Pathways for genes affiliated with Restless Legs Syndrome

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Compounds for genes affiliated with Restless Legs Syndrome

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 2BitterDB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1saporin4410.0HCRT, TFRC
2methylphenidate44 50 1112.0HCRT, DRD2
3alizapride44 1111.0HTR3A, DRD2
4amperozide4410.0DRD2, HTR3A
5droperidol44 1111.0HTR3A, DRD2
6benzamide2 4410.9DRD2, HTR3A
7granisetron50 44 1111.9DRD2, HTR3A
8buspirone44 28 1111.9DRD2, HTR3A
9ritanserin44 2810.9HTR3A, DRD2
10spiperone44 2810.9DRD2, HTR3A
11ergotamine28 44 1111.9DRD2, HTR3A
12perphenazine28 44 50 1112.9DRD2, HTR3A
13iloperidone50 44 28 1112.9DRD2, HTR3A
14aluminium citrate449.8TF, TFRC
15ketanserin44 2810.8DRD2, HTR3A
16clomipramine44 50 1111.8HCRT, HTR3A
17gallium449.8TFRC, TF
18deferiprone449.8TF, TFRC
19lorazepam44 50 1111.8DRD2, HTR3A
20aluminium44 1110.8TFRC, TF
21bismuth44 2410.8TF, TFRC
22apotransferrin449.8TFRC, TF
23iron dextran44 1110.8TFRC, TF
24metoclopramide44 50 1111.8HTR3A, DRD2
25succinylacetone449.8TF, TFRC
26zinc protoporphyrin449.7TFRC, TF
27protoporphyrin ix44 24 1111.7TFRC, TF
28aripiprazole28 44 50 24 1113.7DRD2, HTR3A
29fe3+449.6TFRC, TF
30haloperidol44 50 28 2 1113.6DRD2, HTR3A, HCRT
31tbps44 2810.6TFRC, TF
32yohimbine44 2 28 1112.5HTR3A, DRD2
335-hydroxytryptamine449.5HCRT, HTR3A, DRD2
34opiate449.5DRD2, TF, HCRT
35nh4cl449.5TF, TFRC
36cocaine44 1110.5HCRT, DRD2, TF
37ferric ammonium citrate449.3FTMT, TF, TFRC
38deferoxamine44 1110.3FTMT, TFRC, TF
39epinephrine44 24 1111.3HCRT, DRD2, TF
40fe2+449.3TF, TFRC
41ziprasidone28 50 44 1112.2HTR3A, DRD2
42nmda44 2810.2DRD2, TFRC, HCRT
43acetylcholine44 50 28 24 1113.1TFRC, HTR3A, DRD2, HCRT
44ascorbic acid44 2410.1TF, TFRC, DRD2
45adenylate449.1HCRT, DRD2, HTR3A, TFRC
46gaba449.0HTR3A, DRD2, HCRT, TF
47norepinephrine44 24 1111.0HCRT, HTR3A, TF, DRD2
48histamine44 28 2410.9TF, HCRT, HTR3A, TFRC
49glutamate448.9TF, HCRT, DRD2, TFRC
50dopamine44 28 24 1111.5DRD2, HTR3A, HCRT, TFRC, TF

GO Terms for genes affiliated with Restless Legs Syndrome

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Cellular components related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.3TF, DRD2
2coated pitGO:0059059.1TFRC, TF
3perinuclear region of cytoplasmGO:0484719.0HCRT, TFRC, TF
4integral component of plasma membraneGO:0058878.3DRD2, PCDHA3, HTR3A, TFRC

Biological processes related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term memoryGO:0076169.6DRD2, BTBD9
2response to cocaineGO:0422209.5DRD2, HTR3A
3transferrin transportGO:0335729.1TFRC, TF
4cellular iron ion homeostasisGO:0068798.9FTMT, TFRC, TF
5transmembrane transportGO:0550858.9HTR3A, TFRC, TF

Molecular functions related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTMT, TF

Products for genes affiliated with Restless Legs Syndrome

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  • Antibodies
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Sources for Restless Legs Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet