Restless Legs Syndrome (RLS) malady

MedlinePlus:³³ Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards based summary: Restless Legs Syndrome, also known as willis-ekbom disease, is related to parkinson's disease and migraine. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and HIF-1-alpha transcription factor network. The drugs carbamazepine and clonazepam and the compounds saporin and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are growth/size/body and nervous system.

Disease Ontology:⁹ A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them.

NINDS:⁴³ Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Genetics Home Reference:²² Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

Wikipedia:⁶⁴ Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Descriptions from OMIM:⁴⁶ 612853, 610438, 610439, 608830, 615197 611242, 611185, 102300 more

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Disease Ontology9 DOID:0050425 OMIM46 612853, 610438, 610439 608830, 615197, 611242, 611185, 102300, more

MeSH34 D012148 ICD9CM28 333.94

Clinical features from OMIM:

612853,610438,610439,608830,615197,611242,611185,102300

Search GEO for disease gene expression data for Restless Legs Syndrome.