RLS
MCID: RST001
MIFTS: 55

Restless Legs Syndrome (RLS) malady

Neuronal diseases category

Summaries for Restless Legs Syndrome

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Sources:
22Genetics Home Reference, 35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards: Restless Legs Syndrome, also known as restless legs syndrome, susceptibility to, 1, is related to parkinson's disease and migraine. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and HIF-1-alpha transcription factor network. The drugs carbamazepine and clonazepam and the compounds saporin and methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotypes are growth/size/body and nervous system.

Genetics Home Reference:22 Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

NINDS:45 Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Wikipedia:66 Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Aliases & Classifications for Restless Legs Syndrome

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Sources:
9Disease Ontology, 22Genetics Home Reference, 45NINDS, 46Novoseek, 63UMLS, 35MedlinePlus, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

restless legs syndrome 9 22 45 46 63
restless legs syndrome, susceptibility to, 1 63
restless leg syndrome 22
willis-ekbom disease 22
ekbom's syndrome 22
ekbom syndrome 22
restless legs 35
wed 22
rls 22


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Disease Ontology9 DOID:0050425
MeSH36 D012148

Related Diseases for Restless Legs Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Restless Legs Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 152)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.3DRD2, HCRT, HTR3A
2migraine31.1HTR3A, DRD2, HCRT
3multiple sclerosis31.0HCRT, DRD2, TFRC
4narcolepsy30.9DRD2, HCRT
5schizophrenia30.6HTR3A, HCRT, DRD2
6iron deficiency anemia30.5TFRC, TF
7eating disorder30.3HTR3A, HCRT
8friedreich ataxia30.3FTMT, TFRC
9periodic limb movement disorder10.9
10blindness10.8
11neuropathy10.7
12sleep disorder10.6
13attention deficit hyperactivity disorder10.6
14kidney disease10.5
15restless legs syndrome, susceptibility to, 210.5
16irritable bowel syndrome10.5
17charcot-marie-tooth disease10.5
18hypertension10.5
19tooth disease10.5
20restless legs syndrome, susceptibility to, 110.5
21restless legs syndrome, susceptibility to, 310.5
22restless legs syndrome, susceptibility to, 410.5
23restless legs syndrome, susceptibility to, 510.5
24bruxism10.4
25essential tremor10.4
26pathological gambling10.4
27cerebrovascular disease10.4
28diabetic neuropathy10.4
29impulse control disorder10.4
30migraine with aura10.4
31restless legs syndrome, susceptibility to, 610.4
32ataxia10.4
33headache10.4
34tremor10.4
35insomnia10.4
36deficiency anemia10.3
37axonal neuropathy10.3
38lateral sclerosis10.3
39charcot-marie-tooth disease type 210.3
40amyotrophic lateral sclerosis10.3
41artery disease10.3
42liver disease10.3
43multiple myeloma10.3
44myeloma10.3
45polyneuropathy10.3
46sleep apnea10.3
47spinocerebellar ataxia10.3
48myoclonus10.3
49restless legs syndrome 710.3
50restless legs syndrome 810.3

Graphical network of the top 20 diseases related to Restless Legs Syndrome:



Diseases related to restless legs syndrome

Symptoms for Restless Legs Syndrome

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Drugs & Therapeutics for Restless Legs Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Restless Legs Syndrome

Drug clinical trials:

Search ClinicalTrials for Restless Legs Syndrome

Search NIH Clinical Center for Restless Legs Syndrome

Search CenterWatch for Restless Legs Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Restless Legs Syndrome

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Anatomical Context for Restless Legs Syndrome

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34MalaCards
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MalaCards organs/tissues related to Restless Legs Syndrome:

34
Heart, Lung, Brain, Kidney, Testes, Liver, Skin, Eye, Small intestine, Spinal cord, Cortex, Globus pallidus

Animal Models for Restless Legs Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Restless Legs Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053788.1DRD2, HTR3A, HCRT, TFRC, TF
2MP:00036318.1TFRC, HCRT, HTR3A, DRD2, BTBD9
3MP:00053767.6BTBD9, DRD2, HTR3A, HCRT, TFRC, TF

Publications for Restless Legs Syndrome

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53PubMed
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Articles related to Restless Legs Syndrome:

(show top 50)    (show all 596)
idTitleAuthorsYear
1
Association of candidate genetic variants with restless legs syndrome in end stage renal disease: a multicenter case-control study in Taiwan. (24433515)
2014
2
Treatment of restless legs syndrome. (23703310)
2013
3
Restless legs syndrome: impact on sleep-related breathing disorders. (22882720)
2013
4
Prevalence and associated features of restless legs syndrome in a population of Iranian women during pregnancy. (23886452)
2013
5
Is a diagnosis of ancillary restless legs syndrome reproducible over time? Experience with the Wayne Hening telephone diagnostic interview. (23517586)
2013
6
Bad medicine: restless legs syndrome. (24355578)
2013
7
Improvement of restless legs syndrome by varenicline as antismoking treatment. (24127155)
2013
8
Restless legs syndrome and quality of sleep in patients with glomerulopathy. (23710767)
2013
9
Ascertainment of iron deficiency and depletion in blood donors through screening questions for pica and restless legs syndrome. (23305102)
2013
10
Effectiveness and tolerability of rotigotine transdermal patch for the treatment of restless legs syndrome in a routine clinical practice setting in Germany. (23668924)
2013
11
Characteristics and determinants of restless legs syndrome in pregnancy: a prospective study. (23390174)
2013
12
Restlessness in right upper limb as sole presentation of restless legs syndrome. (23546363)
2013
13
Prospective study of restless legs syndrome and risk of erectile dysfunction. (23608708)
2013
14
Restless legs syndrome in patients with systemic sclerosis. Prevalence and possible causes. (23456369)
2013
15
Restless legs syndrome in a group of patients with Alzheimer's disease. (23264651)
2013
16
Restless legs syndrome: update on pathogenesis. (24048084)
2013
17
Exome sequencing in a family with restless legs syndrome. (23192925)
2012
18
Association between irritable bowel syndrome and restless legs syndrome in the general population. (22463600)
2012
19
Epidemiology of restless legs syndrome: a synthesis of the literature. (21795081)
2012
20
Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. (22672613)
2012
21
European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. (22937989)
2012
22
Combined brain voxel-based morphometry and diffusion tensor imaging study in idiopathic restless legs syndrome patients. (22175823)
2012
23
Restless legs syndrome: a comprehensive overview on its epidemiology, risk factors, and treatment. (22038683)
2012
24
Efficacy and safety of pramipexole in chinese patients with restless legs syndrome: results from a multi-center, randomized, double-blind, placebo-controlled trial. (22137119)
2012
25
Assessing health-related quality of life in patients with restless legs syndrome in Korea: comparison with other chronic medical diseases. (22939530)
2012
26
Prevalence and characteristics of restless legs syndrome (RLS) in the elderly and the relation of serum ferritin levels with disease severity: hospital-based study from Istanbul, Turkey. (21722973)
2012
27
Restless legs syndrome reported by incident haemodialysis patients: is treatment time of day relevant? (22713094)
2012
28
A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. (21677899)
2011
29
Sensory profile in primary restless legs syndrome and restless legs syndrome associated with small fibre neuropathy. (21059747)
2011
30
Restless abdomen: a phenotypic variant of restless legs syndrome. (21917771)
2011
31
Psychiatric comorbidity in children and adolescents with restless legs syndrome: a retrospective study. (22171196)
2011
32
Prevalence and clinical correlates of restless legs syndrome among psychogeriatric patients. (21748800)
2011
33
Pregabalin is more effective than placebo for restless legs syndrome with mild adverse effects of daytime somnolence, headache and unsteadiness. (21081629)
2011
34
Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. (21715702)
2011
35
Restless legs syndrome mothers and attention-deficit/hyperactivity disorder children: what happened between them? (20851048)
2011
36
Migraine and restless legs syndrome: is there an association? (21660429)
2011
37
Profile of altered brain iron acquisition in restless legs syndrome. (21398376)
2011
38
Restless legs syndrome and periodic leg movements in sleep. (21056236)
2011
39
No significance of the COMT val158met polymorphism in restless legs syndrome. (20184941)
2010
40
Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch. (20920156)
2010
41
Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. (20629075)
2010
42
Decision making in restless legs syndrome. (20669306)
2010
43
Prevalence and clinical profile of restless legs syndrome in Parkinson's disease. (20737549)
2010
44
Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome. (17659477)
2007
45
Reported bruxism and restless legs syndrome in media personnel with or without irregular shift work. (16134548)
2005
46
Treatment of restless legs syndrome with subcutaneous apomorphine in a patient with short bowel syndrome. (15726274)
2005
47
Circadian variation in neuroendocrine response to L-dopa in patients with restless legs syndrome. (15283001)
2004
48
SLEEP year in review 2003--insomnia, sleep in psychiatric disorders, periodic limb movement disorder/restless legs syndrome, sleep in medical disorders. (15532215)
2004
49
Autosomal dominant restless legs syndrome maps on chromosome 14q. (12764067)
2003
50
Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. (12136060)
2002

Variations for Restless Legs Syndrome

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Expression for genes affiliated with Restless Legs Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Restless Legs Syndrome

Search GEO for disease gene expression data for Restless Legs Syndrome.

Pathways for genes affiliated with Restless Legs Syndrome

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 56Reactome
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Compounds for genes affiliated with Restless Legs Syndrome

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Sources:
46Novoseek, 52PharmGKB, 12DrugBank, 3BitterDB, 30IUPHAR, 25HMDB
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Compounds related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 71)
idCompoundScoreTop Affiliating Genes
1saporin4610.0HCRT, TFRC
2methylphenidate46 52 1212.0HCRT, DRD2
3alizapride46 1211.0HTR3A, DRD2
4amperozide4610.0DRD2, HTR3A
5droperidol46 1211.0HTR3A, DRD2
6benzamide3 4610.9DRD2, HTR3A
7granisetron52 46 1211.9DRD2, HTR3A
8buspirone46 30 1211.9DRD2, HTR3A
9ritanserin46 3010.9HTR3A, DRD2
10spiperone46 3010.9DRD2, HTR3A
11ergotamine30 46 1211.9DRD2, HTR3A
12perphenazine30 46 52 1212.9DRD2, HTR3A
13iloperidone52 46 30 1212.9DRD2, HTR3A
14aluminium citrate469.8TF, TFRC
15ketanserin46 3010.8DRD2, HTR3A
16clomipramine46 52 1211.8HCRT, HTR3A
17gallium469.8TFRC, TF
18deferiprone469.8TF, TFRC
19lorazepam46 52 1211.8DRD2, HTR3A
20aluminium46 1210.8TFRC, TF
21bismuth46 2510.8TF, TFRC
22apotransferrin469.8TFRC, TF
23iron dextran46 1210.8TFRC, TF
24metoclopramide46 52 1211.8HTR3A, DRD2
25succinylacetone469.8TF, TFRC
26zinc protoporphyrin469.7TFRC, TF
27protoporphyrin ix46 25 1211.7TFRC, TF
28aripiprazole30 46 52 25 1213.7DRD2, HTR3A
29fe3+469.6TFRC, TF
30haloperidol46 52 30 3 1213.6DRD2, HTR3A, HCRT
31tbps46 3010.6TFRC, TF
32yohimbine46 3 30 1212.5HTR3A, DRD2
335-hydroxytryptamine469.5HCRT, HTR3A, DRD2
34opiate469.5DRD2, TF, HCRT
35nh4cl469.5TF, TFRC
36cocaine46 1210.5HCRT, DRD2, TF
37ferric ammonium citrate469.3FTMT, TF, TFRC
38deferoxamine46 1210.3FTMT, TFRC, TF
39epinephrine46 25 1211.3HCRT, DRD2, TF
40fe2+469.3TF, TFRC
41ziprasidone30 52 46 1212.2HTR3A, DRD2
42nmda46 3010.2DRD2, TFRC, HCRT
43acetylcholine46 52 30 25 1213.1TFRC, HTR3A, DRD2, HCRT
44ascorbic acid46 2510.1TF, TFRC, DRD2
45adenylate469.1HCRT, DRD2, HTR3A, TFRC
46gaba469.0HTR3A, DRD2, HCRT, TF
47norepinephrine46 25 1211.0HCRT, HTR3A, TF, DRD2
48histamine46 30 2510.9TF, HCRT, HTR3A, TFRC
49glutamate468.9TF, HCRT, DRD2, TFRC
50dopamine46 30 25 1211.5DRD2, HTR3A, HCRT, TFRC, TF

GO Terms for genes affiliated with Restless Legs Syndrome

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17Gene Ontology
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Cellular components related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:0301399.3TF, DRD2
2coated pitGO:0059059.1TF, TFRC
3perinuclear region of cytoplasmGO:0484719.0HCRT, TFRC, TF
4integral component of plasma membraneGO:0058878.3DRD2, PCDHA3, HTR3A, TFRC

Biological processes related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term memoryGO:0076169.6DRD2, BTBD9
2response to cocaineGO:0422209.5DRD2, HTR3A
3transferrin transportGO:0335729.1TFRC, TF
4cellular iron ion homeostasisGO:0068798.9FTMT, TFRC, TF
5transmembrane transportGO:0550858.9HTR3A, TFRC, TF

Molecular functions related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ferric iron bindingGO:0081999.3FTMT, TF

Products for genes affiliated with Restless Legs Syndrome

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Sources for Restless Legs Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet