RLS
MCID: RST001
MIFTS: 56

Restless Legs Syndrome (RLS) malady

Summaries for Restless Legs Syndrome

Sources:
21Genetics Home Reference, 34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards: Restless Legs Syndrome, also known as restless legs syndrome, susceptibility to, 1, is related to parkinson's disease and attention deficit hyperactivity disorder. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and Dopamine receptors. The drugs carbamazepine and clonazepam and the compounds nmda and talipexole have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotype nervous system.

Genetics Home Reference:21 Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

NINDS:44 Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Wikipedia:64 Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Aliases & Classifications for Restless Legs Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 44NINDS, 45Novoseek, 61UMLS, 34MedlinePlus, 35MeSH
See all sources

Aliases & Descriptions:

restless legs syndrome 8 21 44 45 61
restless legs syndrome, susceptibility to, 1 61
restless leg syndrome 21
willis-ekbom disease 21
ekbom's syndrome 21
ekbom syndrome 21
restless legs 34
wed 21
rls 21


External Ids:

Disease Ontology8 DOID:0050425
MeSH35 D012148

Related Diseases for Restless Legs Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Restless Legs Syndrome family:

restless legs syndrome, susceptibility to, 1 restless legs syndrome, susceptibility to, 6
restless legs syndrome, susceptibility to, 2 restless legs syndrome, susceptibility to, 3
restless legs syndrome, susceptibility to, 4 restless legs syndrome, susceptibility to, 5
restless legs syndrome 7 restless legs syndrome 8

Diseases related to Restless Legs Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.2MAOB, NTS, DRD3, DRD2
2attention deficit hyperactivity disorder30.8MAOB, DRD2, DRD1
3narcolepsy30.7DRD1, DRD2, ATXN3, HCRT
4pathological gambling30.6DRD3, DRD2, DRD1
5amyotrophic lateral sclerosis30.4MAOB, TFRC
6alzheimer's disease30.2HCRT, MAOB, NTS, DRD3, DRD2, DRD1
7n syndrome11.0
8periodic limb movement disorder10.9
9sleep disorder10.8
10char syndrome10.7
11adult syndrome10.6
12kid syndrome10.5
13restless legs syndrome, susceptibility to, 210.5
14essential tremor10.4
15irritable bowel syndrome10.4
16tooth disease10.4
17restless legs syndrome, susceptibility to, 110.4
18restless legs syndrome, susceptibility to, 310.4
19restless legs syndrome, susceptibility to, 410.4
20restless legs syndrome, susceptibility to, 510.4
21cardiovascular disease risk factor10.4
22headache10.4
23tremor10.4
24bruxism10.4
25vascular disease10.4
26restless legs syndrome, susceptibility to, 610.4
27ataxia10.4
28insomnia10.4
29deficiency anemia10.3
30axonal neuropathy10.3
31lateral sclerosis10.3
32iron deficiency anemia10.3
33brain disease10.3
34spinocerebellar ataxia10.3
35spinocerebellar ataxia type 310.3
36short syndrome10.3
37german syndrome10.3
38myoclonus10.3
39sleep apnea10.3
40restless legs syndrome 710.3
41restless legs syndrome 810.3
42coronary artery disease,10.1
43machado-joseph disease10.1
44anuria10.1
45major depressive disorder10.1
46myelitis10.1
47uremic neuropathy10.1
48burning mouth syndrome10.1
49frontal lobe epilepsy10.1
50atopic dermatitis10.1

Graphical network of the top 20 diseases related to Restless Legs Syndrome:



Diseases related to restless legs syndrome

Clinical Features for Restless Legs Syndrome

Drugs & Therapeutics for Restless Legs Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Restless Legs Syndrome

Drug clinical trials:

Search ClinicalTrials for Restless Legs Syndrome

Search NIH Clinical Center for Restless Legs Syndrome

Search CenterWatch for Restless Legs Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Restless Legs Syndrome

Anatomical Context for Restless Legs Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Restless Legs Syndrome:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Cortex, Heart, Small intestine, T cells, Globus pallidus

Animal Models for Restless Legs Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Restless Legs Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.8BTBD9, DRD2, DRD3, TFRC, MEIS1, ATXN3

Publications for Restless Legs Syndrome

Sources:
51PubMed
See all sources

Articles related to Restless Legs Syndrome:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Restless legs syndrome and akathisia as manifestations of acute pontine infarction. (23953640)
2014
2
Restlessness in right upper limb as sole presentation of restless legs syndrome. (23546363)
2013
3
The relationship between physical activity, restless legs syndrome, and health-related quality of life in type 2 diabetes. (23203003)
2013
4
The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia. (23494945)
2013
5
Is preeclampsia associated with restless legs syndrome? (23891236)
2013
6
MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome. (23001634)
2013
7
Hyperalgesia and functional sensory loss in restless legs syndrome. (23707286)
2013
8
Relation of the International Restless Legs Syndrome Study Group rating scale with the Clinical Global Impression severity scale, the restless legs syndrome 6-item questionnaire, and the restless legs syndrome-quality of life questionnaire. (24246378)
2013
9
Duloxetine-related galactorrhea and restless legs syndrome: a case report. (24048395)
2013
10
Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan. (23369046)
2013
11
The relationship among restless legs syndrome (Willis-Ekbom Disease), hypertension, cardiovascular disease, and cerebrovascular disease. (23963470)
2013
12
Sensory symptoms in restless legs syndrome: the enigma of pain. (23948222)
2013
13
Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. (23372468)
2013
14
Efficacy and safety of rotigotine in Japanese patients with restless legs syndrome: a phase 3, multicenter, randomized, placebo-controlled, double-blind, parallel-group study. (24055212)
2013
15
Exome sequencing in a family with restless legs syndrome. (23192925)
2012
16
European guidelines on management of restless legs syndrome: report of a joint task force by the European Federation of Neurological Societies, the European Neurological Society and the European Sleep Research Society. (22937989)
2012
17
Ten-year natural course of habitual snoring and restless legs syndrome in a population aged 61-63 years at the baseline. (21725862)
2012
18
Phenocopies in families with essential tremor and restless legs syndrome challenge Mendelian laws. Epigenetics might provide answers. (22521244)
2012
19
Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial. (22317944)
2012
20
Successful treatment with clonazepam and pramipexole of a patient with sleep-related eating disorder associated with restless legs syndrome: a case report. (22481958)
2012
21
Sensations in restless legs syndrome. (22296915)
2012
22
Risk factors and prevalence rate of restless legs syndrome among pregnant women in Taiwan. (22854259)
2012
23
A novel locus for restless legs syndrome on chromosome 13q. (22797413)
2012
24
A phase II, open-label, non-comparative study of Botulinum toxin in Restless Legs Syndrome. (23063302)
2012
25
Restless Legs Syndrome: a common disorder, but rarely diagnosed and barely treated--an Indian experience. (22704403)
2012
26
Restless legs syndrome in Czech patients with multiple sclerosis: an epidemiological and genetic study. (22609020)
2012
27
Restless legs syndrome in dialysis patients: a comparison between hemodialysis and continuous ambulatory peritoneal dialysis. (22271263)
2012
28
Restless abdomen: a phenotypic variant of restless legs syndrome. (21917771)
2011
29
Restless legs syndrome and periodic leg movements in sleep. (21056236)
2011
30
The dopamine transporter is decreased in the striatum of subjects with restless legs syndrome. (21358851)
2011
31
The high frequency of restless legs syndrome in patients with amyotrophic lateral sclerosis. (21314298)
2011
32
Restless legs syndrome enhances cardiovascular risk and mortality in patients with end-stage kidney disease undergoing long-term haemodialysis treatment. (21056943)
2011
33
Systemic lupus and risk of restless legs syndrome. (21324968)
2011
34
Treatment-resistant sensory motor symptoms in persons with SCI may be signs of restless legs syndrome. (21116284)
2011
35
Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch. (20920156)
2010
36
Restless legs syndrome is frequent in narcolepsy with cataplexy patients. (20469811)
2010
37
Restless legs syndrome and pregnancy: follow-up of pregnant women before and after delivery. (21088424)
2010
38
Restless legs syndrome and Parkinson's disease. (20593424)
2010
39
Restless legs syndrome, rapid eye movement sleep behavior disorder, and hypersomnia in patients with two parkin mutations. (19672985)
2009
40
Iron deficiency anemia, pica, and restless legs syndrome in a teenage girl. (17641119)
2008
41
A case of a patient with both chorea and restless legs syndrome. (18583895)
2008
42
Molecular genetic studies of DMT1 on 12q in French-Canadian restless legs syndrome patients and families. (17510944)
2007
43
Restless legs syndrome in narcolepsy: a side effect of sodium oxybate? (17275405)
2007
44
Ferritin subunits in CSF are decreased in restless legs syndrome. (16459164)
2006
45
Selected sleep disorders: restless legs syndrome and periodic limb movement disorder, sleep apnea syndrome, and narcolepsy. (17118276)
2006
46
EFNS guidelines on management of restless legs syndrome and periodic limb movement disorder in sleep. (16987157)
2006
47
Autosomal dominant restless legs syndrome maps on chromosome 14q. (12764067)
2003
48
Increased CSF hypocretin-1 (orexin-A) in restless legs syndrome. (12196669)
2002
49
Practice parameters for the treatment of restless legs syndrome and periodic limb movement disorder. An American Academy of Sleep Medicine Report. Standards of Practice Committee of the American Academy of Sleep Medicine. (10566915)
1999
50
Restless legs syndrome in uremic neuropathy. (4286316)
1966

Genetic Variations for Restless Legs Syndrome

Expression for genes affiliated with Restless Legs Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Restless Legs Syndrome

Search GEO for disease gene expression data for Restless Legs Syndrome.

Pathways for genes affiliated with Restless Legs Syndrome

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 30KEGG
See all sources

Compounds for genes affiliated with Restless Legs Syndrome

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nmda45 2911.7TFRC, HCRT, MAOB
2talipexole4510.7DRD3, MAOB, DRD2
3eticlopride29 4511.7DRD3, DRD1, DRD2
4cis flupentixol2910.7DRD3, DRD2, DRD1
5sch 233904510.6DRD3, DRD1, DRD2
6(+)-butaclamol29 4511.6DRD3, DRD1, DRD2
7piribedil29 4511.6MAOB, DRD3, DRD2
8rotigotine45 29 1112.6DRD1, DRD3, DRD2, MAOB
9d amphetamine4510.6DRD1, DRD2, MAOB
10methylphenidate45 50 1112.6HCRT, MAOB, DRD2, DRD1
11raclopride45 2911.6DRD1, DRD2, DRD3
12sulpiride45 29 1112.6NTS, DRD1, DRD2, DRD3
13ropinirole45 1111.6DRD3, DRD1, DRD2, MAOB
14Chlorprothixene1110.6DRD3, DRD1, DRD2
15quinpirole45 2911.6DRD1, DRD3, NTS, DRD2
16spiperone29 4511.6DRD1, DRD3, DRD2
17dopac4510.6DRD1, DRD3, MAOB
18amantadine45 1111.6DRD3, MAOB, DRD2
19apomorphine45 29 1112.6DRD3, DRD2, DRD1, MAOB, NTS
20domperidone45 29 1112.6DRD1, DRD2, DRD3
21amphetamine45 1111.6MAOB, HCRT, NTS, DRD2, DRD1
22methamphetamine45 50 1112.5MAOB, DRD1, NTS, DRD3, DRD2
236-hydroxydopamine4510.5DRD1, NTS, MAOB, DRD2, DRD3
24reserpine45 29 1112.5DRD2, NTS, MAOB
25chlorpromazine45 29 50 1113.5DRD1, DRD2, DRD3, NTS
26mptp4510.5DRD3, DRD2, MAOB, DRD1
27thioridazine29 45 50 1113.5DRD2, NTS, DRD1
28olanzapine50 45 29 11 2414.5DRD1, DRD2, NTS, DRD3
29lisuride29 45 1112.5DRD3, DRD1, DRD2
30opiate4510.5NTS, DRD1, DRD2, DRD3, TF, HCRT
31pergolide29 45 1112.5DRD1, DRD2, DRD3
32catecholamine4510.5DRD1, NTS, HCRT, MAOB, DRD3
33haloperidol45 29 2 50 1114.5NTS, DRD1, DRD2, MAOB, HCRT, DRD3
34levodopa45 1111.5MAOB, NTS, TF, DRD3, DRD2, DRD1
35paliperidone45 1111.5DRD2, DRD3, DRD1
36iloperidone50 45 29 1113.5DRD2, DRD1, DRD3
37nicotine45 50 29 1113.5NTS, HCRT, DRD1, DRD3, MAOB, DRD2
38gaba4510.4DRD2, DRD1, TF, NTS, MAOB, HCRT
39Methotrimeprazine1110.4DRD1, DRD2, DRD3
40cocaine45 1111.4TF, DRD2, DRD1, NTS, MAOB, DRD3
41pramipexole45 50 29 1113.4DRD1, DRD3, DRD2
42norepinephrine45 11 2412.4TF, DRD1, HCRT, DRD3, NTS, MAOB
43dopamine45 29 11 2413.4DRD2, MAOB, NTS, TFRC, TF, DRD3
44Acetophenazine1110.3DRD2, DRD1
45clozapine45 29 50 1113.3NTS, DRD3, DRD2, DRD1
46glutamate4510.3TF, TFRC, DRD3, DRD2, NTS, MAOB
47asenapine29 1111.3DRD1, DRD3, DRD2
48epinephrine45 11 2412.2MAOB, HCRT, TF, DRD2, NTS
49cabergoline29 45 1112.2DRD3, DRD2, DRD1
50pd 12890745 2911.0DRD2, DRD3

GO Terms for genes affiliated with Restless Legs Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:03013910.3TF, DRD3, DRD2

Biological processes related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.6DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2, DRD1
6dopamine metabolic processGO:04241710.6DRD3, DRD2, DRD1
7behavioral response to cocaineGO:04814810.6DRD1, DRD2, DRD3
8cerebral cortex GABAergic interneuron migrationGO:02185310.6DRD1, DRD2
9synaptic transmission, dopaminergicGO:00196310.6DRD1, DRD2, DRD3
10prepulse inhibitionGO:06013410.6DRD3, DRD2, DRD1
11peristalsisGO:03043210.6DRD2, DRD1
12response to amphetamineGO:00197510.6DRD1, DRD2, DRD3
13phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD2, DRD1
14regulation of dopamine secretionGO:01405910.6DRD2, DRD3
15visual learningGO:00854210.6DRD1, DRD2, DRD3
16adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
17G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2
18negative regulation of protein secretionGO:05070910.5DRD3, DRD2
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.4DRD1, DRD2
20arachidonic acid secretionGO:05048210.4DRD2, DRD3
21positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
22response to drugGO:04249310.3DRD1, DRD2, DRD3, MAOB
23temperature homeostasisGO:00165910.3DRD2, DRD1
24circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
25grooming behaviorGO:00762510.0DRD1, DRD2

Molecular functions related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD3, DRD2
2dopamine bindingGO:03524010.0DRD3, DRD2, DRD1

Products for genes affiliated with Restless Legs Syndrome

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Sources for Restless Legs Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet