RLS
MCID: RST001
MIFTS: 56

Restless Legs Syndrome (RLS) malady

Summaries for Restless Legs Syndrome

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21Genetics Home Reference, 33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Restless legs syndrome (rls) causes a powerful urge to move your legs. your legs become uncomfortable when you are lying down or sitting. some people describe it as a creeping, crawling, tingling, or burning sensation. moving makes your legs feel better, but not for long. rls can make it hard to fall asleep and stay asleep. in most cases, there is no known cause for rls. in other cases, rls is caused by a disease or condition, such as anemia or pregnancy. some medicines can also cause temporary rls. caffeine, tobacco, and alcohol may make symptoms worse. lifestyle changes, such as regular sleep habits, relaxation techniques, and moderate exercise during the day can help. if those don't work, medicines may reduce the symptoms of rls. most people with rls also have a condition called periodic limb movement disorder (plmd). plmd is a condition in which a person's legs twitch or jerk uncontrollably, usually during sleep. plmd and rls can also affect the arms. nih: national heart, lung, and blood institute

MalaCards: Restless Legs Syndrome, also known as restless legs syndrome, susceptibility to, 1, is related to parkinson's disease and migraine. An important gene associated with Restless Legs Syndrome is BTBD9 (BTB (POZ) domain containing 9), and among its related pathways are Iron metabolism in placenta and Dopamine receptors. The drugs carbamazepine and clonazepam and the compounds nmda and talipexole have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and brain, and related mouse phenotype nervous system.

Genetics Home Reference:21 Restless legs syndrome is a neurological condition that causes an irresistible urge to move the legs. The movement is triggered by strange or uncomfortable feelings, often described as crawling, pulling, or itching, deep within both legs. The feelings usually occur while the affected person is sitting or lying down and are worse at night. Movement, such as kicking, stretching, rubbing, or pacing, make the discomfort go away, at least temporarily. The unpleasant feelings and the resulting need to move the legs often make it difficult for an affected person to fall asleep or stay asleep.

NINDS:43 Restless legs syndrome (RLS) is a neurological disorder characterized by unpleasant sensations in the legs and an uncontrollable, and sometimes overwhelming, urge to move them for relief. Individuals affected with the disorder often describe the sensations as throbbing, polling, or creeping. The sensations range in severity from uncomfortable to irritating to painful.

Wikipedia:63 Restless legs syndrome (RLS) also known as Willis-Ekbom disease (WED) or Wittmaack-Ekbom syndrome, is a... more...

Aliases & Classifications for Restless Legs Syndrome

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8Disease Ontology, 21Genetics Home Reference, 43NINDS, 44Novoseek, 60UMLS, 33MedlinePlus, 34MeSH
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Aliases & Descriptions:

restless legs syndrome 8 21 43 44 60
restless legs syndrome, susceptibility to, 1 60
restless leg syndrome 21
willis-ekbom disease 21
ekbom's syndrome 21
ekbom syndrome 21
restless legs 33
wed 21
rls 21


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Disease Ontology8 DOID:0050425
MeSH34 D012148

Related Diseases for Restless Legs Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Restless Legs Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 135)
idRelated DiseaseScoreTop Affiliating Genes
1parkinson's disease31.2MAOB, NTS, DRD3, DRD2
2migraine31.0HCRT, MAOB, DRD3, DRD2, DRD1
3multiple sclerosis30.9HCRT, TFRC, DRD2
4attention deficit hyperactivity disorder30.8MAOB, DRD2, DRD1
5narcolepsy30.7DRD1, DRD2, ATXN3, HCRT
6pathological gambling30.5DRD3, DRD2, DRD1
7schizophrenia30.5DRD1, DRD2, DRD3, NTS, MAOB, HCRT
8amyotrophic lateral sclerosis30.4MAOB, TFRC
9alzheimer's disease30.2HCRT, MAOB, NTS, DRD3, DRD2, DRD1
10periodic limb movement disorder10.9
11sleep disorder10.8
12neuropathy10.7
13adult syndrome10.6
14image syndrome10.5
15kidney disease10.5
16restless legs syndrome, susceptibility to, 210.5
17essential tremor10.4
18irritable bowel syndrome10.4
19charcot-marie-tooth disease10.4
20diabetic neuropathy10.4
21hypertension10.4
22tooth disease10.4
23restless legs syndrome, susceptibility to, 110.4
24restless legs syndrome, susceptibility to, 310.4
25restless legs syndrome, susceptibility to, 410.4
26restless legs syndrome, susceptibility to, 510.4
27bruxism10.4
28cerebrovascular disease10.4
29impulse control disorder10.4
30migraine with aura10.4
31vascular disease10.4
32spinocerebellar ataxia type 310.4
33restless legs syndrome, susceptibility to, 610.4
34deficiency anemia10.3
35axonal neuropathy10.3
36major depressive disorder10.3
37lateral sclerosis10.3
38charcot-marie-tooth disease type 210.3
39iron deficiency anemia10.3
40brain disease10.3
41epilepsy syndrome10.3
42liver disease10.3
43multiple myeloma10.3
44myeloma10.3
45peripheral neuropathy10.3
46polyneuropathy10.3
47spinocerebellar ataxia10.3
48restless legs syndrome 710.3
49restless legs syndrome 810.3
50burns10.1

Graphical network of the top 20 diseases related to Restless Legs Syndrome:



Diseases related to restless legs syndrome

Clinical Features for Restless Legs Syndrome

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Drugs & Therapeutics for Restless Legs Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Restless Legs Syndrome

Drug clinical trials:

Search ClinicalTrials for Restless Legs Syndrome

Search NIH Clinical Center for Restless Legs Syndrome

Search CenterWatch for Restless Legs Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Restless Legs Syndrome

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Anatomical Context for Restless Legs Syndrome

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32MalaCards
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MalaCards organs/tissues related to Restless Legs Syndrome:

32
Heart, Lung, Brain, Testes, Kidney, Liver, Cortex, Small intestine, Eye, Spinal cord, Skin, Globus pallidus

Animal Models for Restless Legs Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Restless Legs Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.8BTBD9, DRD2, DRD3, TFRC, MEIS1, ATXN3

Publications for Restless Legs Syndrome

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50PubMed
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Articles related to Restless Legs Syndrome:

(show top 50)    (show all 602)
idTitleAuthorsYear
1
Restless legs syndrome and akathisia as manifestations of acute pontine infarction. (23953640)
2014
2
Treatment of restless legs syndrome. (23703310)
2013
3
Restless legs syndrome and quality of sleep in patients with glomerulopathy. (23710767)
2013
4
Phototoxic Rash during Therapy with Pramipexole in a Patient with Restless Legs Syndrome. (23573408)
2013
5
Low brain iron content in idiopathic restless legs syndrome patients detected by phase imaging. (23780623)
2013
6
Restless legs syndrome or Willis-Ekbom disease: what is in a name? (23218536)
2013
7
Is preeclampsia associated with restless legs syndrome? (23891236)
2013
8
MAPT1 gene rs1052553 variant is unrelated with the risk for restless legs syndrome. (23001634)
2013
9
Hyperalgesia and functional sensory loss in restless legs syndrome. (23707286)
2013
10
Actigraphic assessment of periodic leg movements in patients with restless legs syndrome. (23530689)
2013
11
Migraine and restless leg syndrome co-morbidity may be due to iron deficiency. (24101854)
2013
12
Safety and efficacy of rotigotine transdermal patch in patients with restless legs syndrome: a post-hoc analysis of patients taking 1 - 3 mg/24 h for up to 5 years. (23256574)
2013
13
Application of the Cambridge-Hopkins diagnostic questionnaire for investigating restless legs syndrome in patients with chronic renal failure. (23036266)
2013
14
The solute carrier family 1 (glial high affinity glutamate transporter), member 2 gene, SLC1A2, rs3794087 variant and assessment risk for restless legs syndrome. (24424098)
2013
15
Restless legs syndrome and conditions associated with metabolic dysregulation, sympathoadrenal dysfunction, and cardiovascular disease risk: a systematic review. (21733722)
2012
16
The low prevalence of primary restless legs syndrome in Thai Parkinson's disease patients at Chulalongkorn University Hospital. (22435246)
2012
17
Living with restless legs syndrome. (23033555)
2012
18
Clinical correlates of the restless legs syndrome. (22836460)
2012
19
Strategies for the treatment of restless legs syndrome. (22923001)
2012
20
Association of multiple sclerosis with restless legs syndrome and other sleep disorders in women. (22539566)
2012
21
Prospective study of restless legs syndrome and coronary heart disease among women. (22967852)
2012
22
Prospective evaluation of the frequency and treatment of restless legs syndrome in a palliative care unit. (23131706)
2012
23
Efficacy and safety of dopamine agonists in restless legs syndrome. (22281001)
2012
24
Dopa responsive burning mouth syndrome: restless mouth syndrome or oral variant of restless legs syndrome? (22819057)
2012
25
Preferential D2 or preferential D3 dopamine agonists in restless legs syndrome. (21715702)
2011
26
Restless legs syndrome mothers and attention-deficit/hyperactivity disorder children: what happened between them? (20851048)
2011
27
The high frequency of restless legs syndrome in patients with amyotrophic lateral sclerosis. (21314298)
2011
28
Restless legs syndrome is not associated with migraine with aura: a clinical study. (21533734)
2011
29
Pathological gambling plus hypersexuality in restless legs syndrome: a new case. (21567182)
2011
30
Acupuncture for restless legs syndrome in patients previously treated with dopaminergic drugs. (21697212)
2011
31
Opioids protect against substantia nigra cell degeneration under conditions of iron deprivation: a mechanism of possible relevance to the Restless Legs Syndrome (RLS) and Parkinson's disease. (21376342)
2011
32
The restless legs syndrome: is it more than that? (21537239)
2011
33
A prevalence study of restless legs syndrome in Turkish children and adolescents. (21339085)
2011
34
A neurophysiological approach to the complex organisation of the spine: F-wave duration and the cutaneous silent period in restless legs syndrome. (20724211)
2011
35
Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndrome. (21611981)
2011
36
Restless legs syndrome in BehAset's disease. (21819706)
2011
37
Are we aware of restless legs syndrome in COPD patients who are in an exacerbation period? Frequency and probable factors related to underlying mechanism. (22149404)
2011
38
Rotigotine improves restless legs syndrome: a 6-month randomized, double-blind, placebo-controlled trial in the United States. (20629075)
2010
39
Restless legs syndrome associated with narcolepsy and somnambulism. (19703790)
2010
40
Restless legs syndrome in Parkinson's disease: clinical characteristics and biochemical correlations. (21243243)
2010
41
Rotigotine transdermal patch for the treatment of Parkinson's disease and restless legs syndrome. (20683503)
2010
42
Update in restless legs syndrome. (20581683)
2010
43
Rotigotine transdermal patch in moderate to severe idiopathic restless legs syndrome: a randomized, placebo-controlled polysomnographic study. (20813583)
2010
44
Advances in pediatric restless legs syndrome: Iron, genetics, diagnosis and treatment. (20620105)
2010
45
Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease. (18207455)
2009
46
Restless legs syndrome and diabetic neuropathy. (18363304)
2008
47
Spinocerebellar ataxia type 1, 2, and 3 and restless legs syndrome: striatal dopamine D2 receptor status investigated by [11C]raclopride positron emission tomography. (16941469)
2006
48
An update on the dopaminergic treatment of restless legs syndrome and periodic limb movement disorder. (15164915)
2004
49
Evidence for a genetic association between monoamine oxidase A and restless legs syndrome. (12136060)
2002
50
An FDOPA PET study in patients with periodic limb movement disorder and restless legs syndrome. (10668725)
2000

Genetic Variations for Restless Legs Syndrome

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Expression for genes affiliated with Restless Legs Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Restless Legs Syndrome

Search GEO for disease gene expression data for Restless Legs Syndrome.

Pathways for genes affiliated with Restless Legs Syndrome

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 29KEGG
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Compounds for genes affiliated with Restless Legs Syndrome

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 124)
idCompoundScoreTop Affiliating Genes
1nmda44 2811.7TFRC, MAOB, HCRT
2talipexole4410.7MAOB, DRD3, DRD2
3eticlopride28 4411.7DRD1, DRD2, DRD3
4cis flupentixol2810.7DRD1, DRD2, DRD3
5(+)-butaclamol28 4411.6DRD1, DRD2, DRD3
6sch 233904410.6DRD1, DRD2, DRD3
7piribedil28 4411.6DRD2, DRD3, MAOB
8rotigotine44 28 1112.6DRD1, DRD2, DRD3, MAOB
9d amphetamine4410.6DRD1, DRD2, MAOB
10methylphenidate44 49 1112.6DRD1, DRD2, MAOB, HCRT
11raclopride44 2811.6DRD3, DRD2, DRD1
12sulpiride44 28 1112.6DRD1, DRD2, DRD3, NTS
13ropinirole44 1111.6DRD1, DRD2, DRD3, MAOB
14Chlorprothixene1110.6DRD1, DRD2, DRD3
15quinpirole44 2811.6DRD1, DRD2, DRD3, NTS
16spiperone28 4411.6DRD1, DRD2, DRD3
17dopac4410.6DRD1, DRD3, MAOB
18amantadine44 1111.6MAOB, DRD3, DRD2
19apomorphine44 28 1112.6DRD1, DRD2, DRD3, NTS, MAOB
20domperidone44 28 1112.6DRD1, DRD2, DRD3
21amphetamine44 1111.6DRD1, DRD2, NTS, MAOB, HCRT
22methamphetamine44 49 1112.5DRD1, DRD2, DRD3, NTS, MAOB
23reserpine44 28 1112.5DRD2, NTS, MAOB
246-hydroxydopamine4410.5DRD1, DRD2, DRD3, NTS, MAOB
25chlorpromazine44 28 49 1113.5DRD1, DRD2, DRD3, NTS
26mptp4410.5DRD1, DRD2, DRD3, MAOB
27thioridazine28 44 49 1113.5DRD1, DRD2, NTS
28olanzapine49 44 28 11 2414.5NTS, DRD3, DRD2, DRD1
29lisuride28 44 1112.5DRD1, DRD2, DRD3
30opiate4410.5DRD1, DRD2, DRD3, TF, NTS, HCRT
31paliperidone44 1111.5DRD1, DRD2, DRD3
32catecholamine4410.5DRD1, DRD3, NTS, MAOB, HCRT
33haloperidol44 28 2 49 1114.5DRD1, DRD2, DRD3, NTS, MAOB, HCRT
34levodopa44 1111.5DRD1, DRD2, DRD3, TF, NTS, MAOB
35pergolide28 44 1112.5DRD1, DRD2, DRD3
36Methotrimeprazine1110.5DRD1, DRD2, DRD3
37nicotine44 49 28 1113.5DRD1, DRD2, DRD3, NTS, MAOB, HCRT
38gaba4410.4DRD1, DRD2, TF, NTS, MAOB, HCRT
39pramipexole44 49 28 1113.4DRD1, DRD2, DRD3
40cocaine44 1111.4HCRT, DRD1, DRD2, DRD3, TF, NTS
41iloperidone49 44 28 1113.4DRD1, DRD2, DRD3
42norepinephrine44 11 2412.4DRD1, DRD2, DRD3, TF, NTS, MAOB
43dopamine44 28 11 2413.4DRD1, DRD2, DRD3, TF, TFRC, NTS
44Acetophenazine1110.3DRD2, DRD1
45clozapine44 28 49 1113.3DRD1, DRD2, DRD3, NTS
46glutamate4410.3DRD1, DRD2, DRD3, TF, TFRC, NTS
47asenapine28 1111.3DRD3, DRD2, DRD1
48epinephrine44 11 2412.2DRD2, TF, NTS, MAOB, HCRT
49cabergoline28 44 1112.2DRD1, DRD2, DRD3
50pd 12890744 2811.0DRD3, DRD2

GO Terms for genes affiliated with Restless Legs Syndrome

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16Gene Ontology
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Cellular components related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicleGO:03013910.3TF, DRD3, DRD2

Biological processes related to Restless Legs Syndrome according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1response to histamineGO:03477610.7DRD3, DRD2
2negative regulation of dopamine receptor signaling pathwayGO:06016010.7DRD3, DRD2
3adenylate cyclase-inhibiting dopamine receptor signaling pathwayGO:00719510.6DRD3, DRD2
4regulation of cAMP metabolic processGO:03081410.6DRD3, DRD2
5regulation of dopamine uptake involved in synaptic transmissionGO:05158410.6DRD3, DRD2, DRD1
6dopamine metabolic processGO:04241710.6DRD3, DRD2, DRD1
7behavioral response to cocaineGO:04814810.6DRD1, DRD2, DRD3
8cerebral cortex GABAergic interneuron migrationGO:02185310.6DRD1, DRD2
9synaptic transmission, dopaminergicGO:00196310.6DRD1, DRD2, DRD3
10prepulse inhibitionGO:06013410.6DRD3, DRD2, DRD1
11peristalsisGO:03043210.6DRD2, DRD1
12response to amphetamineGO:00197510.6DRD1, DRD2, DRD3
13phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.6DRD2, DRD1
14regulation of dopamine secretionGO:01405910.6DRD2, DRD3
15visual learningGO:00854210.6DRD1, DRD2, DRD3
16adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.5DRD1, DRD3
17G-protein coupled receptor internalizationGO:00203110.5DRD3, DRD2
18negative regulation of protein secretionGO:05070910.5DRD3, DRD2
19elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.4DRD1, DRD2
20arachidonic acid secretionGO:05048210.4DRD2, DRD3
21positive regulation of renal sodium excretionGO:03581510.3DRD2, DRD3
22response to drugGO:04249310.3DRD1, DRD2, DRD3, MAOB
23temperature homeostasisGO:00165910.3DRD2, DRD1
24circadian regulation of gene expressionGO:03292210.2DRD2, DRD3
25grooming behaviorGO:00762510.0DRD1, DRD2

Molecular functions related to Restless Legs Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via Gi/GoGO:00159110.3DRD3, DRD2
2dopamine bindingGO:03524010.0DRD3, DRD2, DRD1

Products for genes affiliated with Restless Legs Syndrome

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Sources for Restless Legs Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet