MCID: RST020
MIFTS: 19

Restless Legs Syndrome 6

Categories: Rare diseases

Aliases & Classifications for Restless Legs Syndrome 6

MalaCards integrated aliases for Restless Legs Syndrome 6:

Name: Restless Legs Syndrome 6 53 71
Restless Legs Syndrome, Susceptibility to, 6 53 49 13
Rls6 53 49 71
Periodic Limb Movements in Sleep 53 49

Classifications:



External Ids:

OMIM 53 611185
MedGen 39 C1970020
MeSH 41 D012148

Summaries for Restless Legs Syndrome 6

OMIM : 53 Restless legs syndrome (RLS) is a neurologic disorder characterized by an uncontrollable urge to move the legs during periods of rest. The majority of patients with RLS also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep. Limb movements during sleep are more common in otherwise asymptomatic family members of patients with RLS compared to the general population (Stefansson et al., 2007). Thus, periodic limb movements during sleep may serve as an endophenotype for RLS. However, not all patients with RLS have limb movements during sleep, and the majority of individuals with limb movements during sleep do not have waking symptoms of RLS (Winkelman, 2007). For additional information and a discussion of genetic heterogeneity of RLS, see RLS1 (102300). (611185)

MalaCards based summary : Restless Legs Syndrome 6, also known as restless legs syndrome, susceptibility to, 6, is related to restless legs syndrome and restless legs syndrome 7. An important gene associated with Restless Legs Syndrome 6 is RLS6 (Restless Legs Syndrome, Susceptibility To, 6). The drugs Dopamine and Benzocaine have been mentioned in the context of this disorder.

UniProtKB/Swiss-Prot : 71 Restless legs syndrome 6: A neurologic sleep/wake disorder characterized by uncomfortable and unpleasant sensations in the legs that appear at rest, usually at night, inducing an irresistible desire to move the legs. The disorder results in nocturnal insomnia and chronic sleep deprivation. The majority of patients also have periodic limb movements in sleep, which are characterized by involuntary, highly stereotypical, regularly occurring limb movements that occur during sleep.

Related Diseases for Restless Legs Syndrome 6

Diseases related to Restless Legs Syndrome 6 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 restless legs syndrome 31.5 BTBD9 RLS6
2 restless legs syndrome 7 11.0

Symptoms & Phenotypes for Restless Legs Syndrome 6

Clinical features from OMIM:

611185

Drugs & Therapeutics for Restless Legs Syndrome 6

Drugs for Restless Legs Syndrome 6 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
2
Benzocaine Approved, Investigational Phase 4,Phase 3 1994-09-7, 94-09-7 2337
3
Iron Approved Phase 4 7439-89-6 23925
4
Pramipexole Approved, Investigational Phase 4,Phase 3,Phase 2 104632-26-0 119570 59868
5
Ropinirole Approved, Investigational Phase 4,Phase 3 91374-20-8, 91374-21-9 5095 497540
6 tannic acid Approved, Nutraceutical Phase 4,Phase 3
7 Dopamine agonists Phase 4,Phase 3,Phase 2
8 N 0437 Phase 4,Phase 3,Phase 2
9 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
10 Dopamine Agents Phase 4,Phase 3,Phase 2,Not Applicable
11 Ferric Compounds Phase 4
12 Micronutrients Phase 4
13 Natriuretic Agents Phase 4
14 Coagulants Phase 4
15 Trace Elements Phase 4
16 Hematinics Phase 4
17 Hemostatics Phase 4
18 Vasopressins Phase 4
19 Deamino Arginine Vasopressin Phase 4
20 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
21 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
22 Arginine Vasopressin Phase 4
23 Antioxidants Phase 4,Phase 3,Phase 2
24 Autonomic Agents Phase 4,Not Applicable
25 Antiparkinson Agents Phase 4,Phase 3,Phase 2
26 arginine Nutraceutical Phase 4
27
Levodopa Approved Phase 3 59-92-7 6047
28
Lisuride Approved, Investigational Phase 3 18016-80-3 28864
29
Cabergoline Approved Phase 3 81409-90-7 54746
30
Pregabalin Approved, Illicit, Investigational Phase 3 148553-50-8 5486971
31
Serotonin Phase 3 50-67-9 5202
32 Analgesics Phase 3
33 calcium channel blockers Phase 3
34 Central Nervous System Depressants Phase 3
35 Serotonin Agents Phase 3
36 Tranquilizing Agents Phase 3
37 Anti-Anxiety Agents Phase 3
38 Anticonvulsants Phase 3
39 Psychotropic Drugs Phase 3
40 Calcium, Dietary Phase 3

Interventional clinical trials:

(show all 26)

# Name Status NCT ID Phase Drugs
1 Effect of Rotigotine Patch Treatment on Cardiovascular Markers in Idiopathic Restless Legs Syndrome Unknown status NCT01823770 Phase 4 Rotigotine;Placebo patchs
2 Effects of Neupro on Cardiovascular Observations in Patients With Restless Legs Syndrome Completed NCT01455012 Phase 4 Rotigotine;Placebo
3 Long-term Efficacy, Safety and Tolerability of Pramipexole in Patients With Idiopathic Moderate to Severe Restless Legs Syndrome (RLS) Completed NCT00472199 Phase 4 Pramipexole;Placebo
4 12-week Polysomnography Study of Ropinirole Controlled Release for Restless Legs Syndrome Completed NCT00373542 Phase 4 ropinirole CR-RLS
5 A Phase IV Trial With Pramipexole to Investigate the Effects on RLS Symptoms and Sleep Disturbance in Patients With RLS Completed NCT00349531 Phase 4 Pramipexole
6 Phase IV Trial With Pramipexole to Evaluate Safety and Efficacy in Patients With RLS Associated With Mood Disturbances Completed NCT00356096 Phase 4 pramipexole
7 Desmopressin Melt: Impact on Sleep and Daytime Functioning Completed NCT01645475 Phase 4 Desmopressin lyophilisate (Melt)
8 Switching From Oral Dopamine Agonists to Rotigotine Completed NCT01976871 Phase 4 Rotigotine
9 Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy Completed NCT01245777 Phase 4 ferric carboxymaltose
10 Rotigotine Effect on All-day Functioning and Quality of Life in Subjects With Moderate to Severe Restless Legs Syndrome (RLS) Completed NCT01569464 Phase 3 Rotigotine
11 Transdermal Lisuride: a Trial for the Treatment of Patients With Restless Legs Syndrome (RLS) Completed NCT00367822 Phase 3 Lisuride;Ropinirole;Placebo
12 Phase 3 Open-label Extension Trial With Rotigotine in Idiopathic Restless Legs Syndrome Subjects Completed NCT00498108 Phase 3 Rotigotine
13 Three Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Leg Syndrome Completed NCT00136045 Phase 3 Rotigotine
14 Four Different Transdermal Doses of Rotigotine in Subjects With Idiopathic Restless Legs Syndrome Completed NCT00135993 Phase 3 Rotigotine
15 A Sleep Laboratory Study to Investigate the Safety and Efficacy of the Rotigotine Skin Patch in Subjects With Restless Legs Syndrome and End-Stage Renal Disease Requiring Hemodialysis Completed NCT01537042 Phase 3 Rotigotine;Placebo
16 Pramipexole in Out-patients With Idiopathic Restless Legs Syndrome (IRLS) Completed NCT00654498 Phase 3 Pramipexole;Placebo
17 A Study to Determine the Efficacy and Safety of Cabergoline for the Treatment of Patients With RLS Completed NCT00625547 Phase 3 cabergoline;levodopa
18 A Study to Evaluate the Efficacy and Safety of Cabergoline Compared With Placebo for the Treatment of RLS Completed NCT00627003 Phase 3 Cabergoline
19 Polysomnography Study Of Pregabalin And Pramipexole Versus Placebo In Patients With Restless Legs Syndrome And Associated Sleep Disturbance Completed NCT00991276 Phase 3 pregabalin;placebo;pramipexole
20 Rotigotine Restless Legs Syndrome Dose Finding Trial Completed NCT00243217 Phase 2 SPM 936
21 Pramipexole (BI-Sifrol®) Orally Once Daily for 6 Weeks in Patients With Primary Restless Legs Syndrome Completed NCT00152997 Phase 2 Pramipexole 0.125 mg tablets;Pramipexole 0.125 mg tablets Placebo
22 Verification of Computerized Sleep-wake Analysis in Sleep Disorders Unknown status NCT02412527
23 Non-interventional Observational Study on the Influence of Pramipexole on Sensory Symptoms of Restless Legs Syndrome (RLS) Completed NCT00887289
24 Dopamine Transporter Density Profiles in Patients With Periodic Limb Movements Completed NCT01365364 Not Applicable
25 Observational Study of Sifrol® in Patients With Primary Restless Legs Syndrome (RLS) Completed NCT02248142 Pramipexole
26 The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes Recruiting NCT03383354

Search NIH Clinical Center for Restless Legs Syndrome 6

Genetic Tests for Restless Legs Syndrome 6

Anatomical Context for Restless Legs Syndrome 6

Publications for Restless Legs Syndrome 6

Articles related to Restless Legs Syndrome 6:

# Title Authors Year
1
The Role of Iron in Pediatric Restless Legs Syndrome and Periodic Limb Movements in Sleep. ( 28837991 )
2017
2
The validity of the PAM-RL device for evaluating periodic limb movements in sleep and an investigation on night-to-night variability of periodic limb movements during sleep in patients with restless legs syndrome or periodic limb movement disorder using this system. ( 24269130 )
2014
3
Periodic limb movements in sleep contribute to further cardiac structure abnormalities in hemodialysis patients with restless legs syndrome. ( 23372468 )
2013
4
L-Dopa improves Restless Legs Syndrome and periodic limb movements in sleep but not Attention-Deficit-Hyperactivity Disorder in a double-blind trial in children. ( 21463967 )
2011
5
Remission of severe restless legs syndrome and periodic limb movements in sleep after bilateral excision of multiple foot neuromas: a case report. ( 20849622 )
2010
6
A genetic risk factor for periodic limb movements in sleep. ( 18216367 )
2008
7
Periodic limb movements in sleep and periodic limb movement disorder. ( 17235435 )
2007
8
A genetic risk factor for periodic limb movements in sleep. ( 17634447 )
2007

Variations for Restless Legs Syndrome 6

Expression for Restless Legs Syndrome 6

Search GEO for disease gene expression data for Restless Legs Syndrome 6.

Pathways for Restless Legs Syndrome 6

GO Terms for Restless Legs Syndrome 6

Sources for Restless Legs Syndrome 6

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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