MCID: RTC007
MIFTS: 27

Reticular Perineurioma malady

Neuronal diseases, Cancer diseases categories

Summaries for Reticular Perineurioma

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32MalaCards
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MalaCards: Reticular Perineurioma is related to perineurioma and intraneural perineurioma. An important gene associated with Reticular Perineurioma is MUC1 (mucin 1, cell surface associated), and among its related pathways are Rho Family GTPases and Endocytosis. The compounds trastuzumab and hematoxylin have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Reticular Perineurioma

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48Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

reticular perineurioma 48


Related Diseases for Reticular Perineurioma

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17GeneCards, 18GeneDecks
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Diseases related to Reticular Perineurioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.7MUC1
2intraneural perineurioma10.3
3uterine carcinosarcoma10.0KIT
4uterine sarcoma10.0KIT
5angiomyolipoma10.0KIT
6fibromatosis10.0KIT
7sertoli cell tumor10.0MUC1
8cholangiocarcinoma10.0MUC1
9adenoma10.0MUC1
10interstitial lung disease10.0MUC1
11fibrosarcoma10.0PDGFRA
12chondroma10.0PDGFRA
13medulloblastoma10.0PDGFRA
14osteosarcoma10.0PDGFRA
15myelofibrosis10.0PDGFRA
16anaplastic large cell lymphoma10.0MUC1
17eosinophilia10.0PDGFRA
18pancreatic cancer10.0MUC1
19oligodendroglioma10.0PDGFRA
20dermatofibrosarcoma protuberans10.0KIT, MUC1
21merkel cell carcinoma10.0KIT, MUC1
22malignant mixed mullerian tumor10.0KIT, MUC1
23adenoid cystic carcinoma10.0MUC1, KIT
24thymus cancer10.0KIT, MUC1
25oxyphilic adenoma10.0MUC1, KIT
26neuroendocrine carcinoma10.0MUC1, KIT
27synovial sarcoma10.0KIT, MUC1
28gastrointestinal stromal tumor, somatic10.0PDGFRA, KIT
29mesenchymal cell neoplasm10.0KIT, PDGFRA
30carney triad10.0KIT, PDGFRA
31systemic mastocytosis10.0KIT, PDGFRA
32endometrial stromal sarcoma10.0KIT, PDGFRA
33piebaldism10.0KIT, PDGFRA
34leiomyoma10.0PDGFRA, KIT
35chronic myelomonocytic leukemia10.0KIT, PDGFRA
36malignant peripheral nerve sheath tumor10.0KIT, PDGFRA
37desmoid tumor10.0KIT, PDGFRA
38hypereosinophilic syndrome10.0KIT, PDGFRA
39angiosarcoma10.0MUC1, PDGFRA
40myeloproliferative disorder10.0KIT, PDGFRA
41mastocytosis10.0KIT, PDGFRA
42peripheral primitive neuroectodermal tumor10.0PDGFRA, KIT
43polycythemia vera10.0KIT, PDGFRA
44embryonal cancer10.0PDGFRA, KIT
45neurofibromatosis10.0PDGFRA
46glioblastoma multiforme10.0KIT, PDGFRA
47chordoma10.0MUC1, PDGFRA
48ependymoma10.0MUC1, PDGFRA
49seminoma10.0KIT, PDGFRA
50gastrointestinal stromal tumor10.0PDGFRA, KIT

Graphical network of the top 20 diseases related to Reticular Perineurioma:



Diseases related to reticular perineurioma

Clinical Features for Reticular Perineurioma

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Drugs & Therapeutics for Reticular Perineurioma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reticular Perineurioma

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Anatomical Context for Reticular Perineurioma

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Animal Models for Reticular Perineurioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Reticular Perineurioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PDGFRA, MUC1, KIT
2MP:00030128.5PDGFRA, MUC1, KIT
3MP:00107718.5KIT, PDGFRA, MUC1
4MP:00053818.4KIT, PDGFRA, MUC1
5MP:00053798.2PDGFRA, MUC1, KIT

Publications for Reticular Perineurioma

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Genetic Variations for Reticular Perineurioma

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Expression for genes affiliated with Reticular Perineurioma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticular Perineurioma

Search GEO for disease gene expression data for Reticular Perineurioma.

Pathways for genes affiliated with Reticular Perineurioma

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 4Cell Signaling Technology, 49PharmGKB, 37NCBI BioSystems Database
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Compounds for genes affiliated with Reticular Perineurioma

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Reticular Perineurioma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1trastuzumab44 49 1111.6MUC1, KIT
2hematoxylin449.6KIT, MUC1
3cytarabine44 49 1111.5KIT, MUC1
4pkc 412449.5PDGFRA, KIT
5gold449.5KIT, MUC1
6ag-1296449.5KIT, PDGFRA
7Pazopanib119.5PDGFRA, KIT
8Ponatinib 119.5KIT, PDGFRA
9agarose449.4MUC1, KIT
10Regorafenib119.4KIT, PDGFRA
11sunitinib44 49 1111.4KIT, PDGFRA
12formaldehyde44 2410.4KIT, MUC1
13hydroxyurea44 49 1111.3KIT, PDGFRA
145fluorouracil449.3KIT, MUC1
15imatinib44 49 1111.1PDGFRA, KIT
16methotrexate44 49 1111.0MUC1, KIT
17folate448.9PDGFRA, MUC1
18paraffin448.8PDGFRA, MUC1, KIT
19thymidine44 249.8KIT, PDGFRA, MUC1
20vegf448.8PDGFRA, MUC1, KIT
21estrogen448.7KIT, MUC1, PDGFRA
22retinoic acid44 249.7PDGFRA, MUC1, KIT

GO Terms for genes affiliated with Reticular Perineurioma

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16Gene Ontology
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Cellular components related to Reticular Perineurioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1KIT, PDGFRA

Biological processes related to Reticular Perineurioma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.4KIT, PDGFRA
2cell chemotaxisGO:0603269.3PDGFRA, KIT
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.3PDGFRA, KIT
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.3KIT, PDGFRA
5peptidyl-tyrosine phosphorylationGO:0181089.2PDGFRA, KIT
6phosphatidylinositol-mediated signalingGO:0480159.2PDGFRA, KIT
7protein autophosphorylationGO:0467779.1KIT, PDGFRA
8epidermal growth factor receptor signaling pathwayGO:0071739.1PDGFRA, KIT
9fibroblast growth factor receptor signaling pathwayGO:0085439.0PDGFRA, KIT
10Fc-epsilon receptor signaling pathwayGO:0380958.8PDGFRA, KIT

Molecular functions related to Reticular Perineurioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.1KIT, PDGFRA

Products for genes affiliated with Reticular Perineurioma

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Reticular Perineurioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet