MCID: RTC007
MIFTS: 22

Reticular Perineurioma malady

Neuronal, Cancer categories

Summaries for Reticular Perineurioma

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33MalaCards
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MalaCards: Reticular Perineurioma is related to intraneural perineurioma and uterine carcinosarcoma. An important gene associated with Reticular Perineurioma is MUC1 (mucin 1, cell surface associated), and among its related pathways are Rho Family GTPases and Signaling by the B Cell Receptor (BCR). The compounds trastuzumab and hematoxylin have been mentioned in the context of this disorder. Affiliated tissues include skin, and related mouse phenotypes are tumorigenesis and no phenotypic analysis.

Aliases & Classifications for Reticular Perineurioma

Sources:
49Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

reticular perineurioma 49


Related Diseases for Reticular Perineurioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Reticular Perineurioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1intraneural perineurioma10.3
2uterine carcinosarcoma10.0KIT
3uterine sarcoma10.0KIT
4perineurioma10.0MUC1
5angiomyolipoma10.0KIT
6fibromatosis10.0KIT
7sertoli cell tumor10.0MUC1
8cholangiocarcinoma10.0MUC1
9adenoma10.0MUC1
10interstitial lung disease10.0MUC1
11fibrosarcoma10.0PDGFRA
12chondroma10.0PDGFRA
13medulloblastoma10.0PDGFRA
14osteosarcoma10.0PDGFRA
15myelofibrosis10.0PDGFRA
16anaplastic large cell lymphoma10.0MUC1
17eosinophilia10.0PDGFRA
18pancreatic cancer10.0MUC1
19oligodendroglioma10.0PDGFRA
20dermatofibrosarcoma protuberans10.0KIT, MUC1
21merkel cell carcinoma10.0KIT, MUC1
22malignant mixed mullerian tumor10.0KIT, MUC1
23adenoid cystic carcinoma10.0MUC1, KIT
24thymic carcinoma10.0KIT, MUC1
25oxyphilic adenoma10.0MUC1, KIT
26neuroendocrine carcinoma10.0MUC1, KIT
27synovial sarcoma10.0KIT, MUC1
28gastrointestinal stromal tumor, somatic10.0PDGFRA, KIT
29mesenchymal cell neoplasm10.0KIT, PDGFRA
30carney triad10.0KIT, PDGFRA
31systemic mastocytosis10.0KIT, PDGFRA
32endometrial stromal sarcoma10.0KIT, PDGFRA
33piebaldism10.0KIT, PDGFRA
34leiomyoma10.0PDGFRA, KIT
35chronic myelomonocytic leukemia10.0KIT, PDGFRA
36malignant peripheral nerve sheath tumor10.0KIT, PDGFRA
37desmoid tumor10.0KIT, PDGFRA
38hypereosinophilic syndrome10.0KIT, PDGFRA
39angiosarcoma10.0MUC1, PDGFRA
40myeloproliferative disorder10.0KIT, PDGFRA
41mastocytosis10.0KIT, PDGFRA
42peripheral primitive neuroectodermal tumor10.0PDGFRA, KIT
43polycythemia vera10.0KIT, PDGFRA
44embryonal cancer10.0PDGFRA, KIT
45neurofibromatosis10.0PDGFRA
46glioblastoma multiforme10.0KIT, PDGFRA
47chordoma10.0MUC1, PDGFRA
48ependymoma10.0MUC1, PDGFRA
49seminoma10.0KIT, PDGFRA
50gastrointestinal stromal tumor10.0PDGFRA, KIT

Graphical network of the top 20 diseases related to Reticular Perineurioma:



Diseases related to reticular perineurioma

Clinical Features for Reticular Perineurioma

Drugs & Therapeutics for Reticular Perineurioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reticular Perineurioma

Anatomical Context for Reticular Perineurioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Reticular Perineurioma:

33
Skin

Animal Models for Reticular Perineurioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Reticular Perineurioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.6PDGFRA, MUC1, KIT
2MP:00030128.5PDGFRA, MUC1, KIT
3MP:00107718.5KIT, PDGFRA, MUC1
4MP:00053818.4KIT, PDGFRA, MUC1
5MP:00053798.2PDGFRA, MUC1, KIT

Publications for Reticular Perineurioma

Sources:
51PubMed
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Articles related to Reticular Perineurioma:

idTitleAuthorsYear
1
Challenging differential diagnosis of a wild-type gastrointestinal stromal tumour (GIST) or rare reticular perineurioma of the stomach? The role for mutational analysis. (21725412)
2011
2
Intraneural reticular perineurioma of the hypoglossal nerve. (18972430)
2009
3
Reticular and plexiform perineurioma: clinicopathological and immunohistochemical analysis of two cases and review of perineurial neoplasms of skin and soft tissues. (16133356)
2005
4
Intraneural reticular perineurioma of the neck. (12715338)
2003
5
Reticular perineurioma: a distinctive variant of soft tissue perineurioma. (11257623)
2001

Genetic Variations for Reticular Perineurioma

Expression for genes affiliated with Reticular Perineurioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticular Perineurioma

Search GEO for disease gene expression data for Reticular Perineurioma.

Pathways for genes affiliated with Reticular Perineurioma

Sources:
52QIAGEN, 54Reactome, 30KEGG, 4Cell Signaling Technology, 50PharmGKB, 38NCBI BioSystems Database
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Compounds for genes affiliated with Reticular Perineurioma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB
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Compounds related to Reticular Perineurioma according to GeneCards/GeneDecks:

(show all 22)
idCompoundScoreTop Affiliating Genes
1trastuzumab45 50 1111.6MUC1, KIT
2hematoxylin459.6MUC1, KIT
3cytarabine45 50 1111.5KIT, MUC1
4pkc 412459.5KIT, PDGFRA
5gold459.5MUC1, KIT
6ag-1296459.5KIT, PDGFRA
7Pazopanib119.5KIT, PDGFRA
8Ponatinib 119.5PDGFRA, KIT
9agarose459.4KIT, MUC1
10Regorafenib119.4PDGFRA, KIT
11sunitinib45 50 1111.4KIT, PDGFRA
12formaldehyde45 2410.4KIT, MUC1
13hydroxyurea45 50 1111.3KIT, PDGFRA
145fluorouracil459.3KIT, MUC1
15imatinib45 50 1111.1PDGFRA, KIT
16methotrexate45 50 1111.0KIT, MUC1
17folate458.9MUC1, PDGFRA
18paraffin458.8KIT, MUC1, PDGFRA
19thymidine45 249.8KIT, MUC1, PDGFRA
20vegf458.8KIT, MUC1, PDGFRA
21estrogen458.7KIT, MUC1, PDGFRA
22retinoic acid45 249.7PDGFRA, MUC1, KIT

GO Terms for genes affiliated with Reticular Perineurioma

Sources:
16Gene Ontology
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Cellular components related to Reticular Perineurioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1KIT, PDGFRA

Biological processes related to Reticular Perineurioma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of phospholipase C activityGO:0108639.4KIT, PDGFRA
2cell chemotaxisGO:0603269.3KIT, PDGFRA
3positive regulation of phosphatidylinositol 3-kinase activityGO:0435529.3PDGFRA, KIT
4positive regulation of phosphatidylinositol 3-kinase cascadeGO:0140689.3KIT, PDGFRA
5peptidyl-tyrosine phosphorylationGO:0181089.2KIT, PDGFRA
6phosphatidylinositol-mediated signalingGO:0480159.2PDGFRA, KIT
7protein autophosphorylationGO:0467779.1KIT, PDGFRA
8epidermal growth factor receptor signaling pathwayGO:0071739.1KIT, PDGFRA
9fibroblast growth factor receptor signaling pathwayGO:0085439.0KIT, PDGFRA
10Fc-epsilon receptor signaling pathwayGO:0380958.8KIT, PDGFRA

Molecular functions related to Reticular Perineurioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane receptor protein tyrosine kinase activityGO:0047149.1KIT, PDGFRA

Products for genes affiliated with Reticular Perineurioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Reticular Perineurioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet