Aliases & Classifications for Reticuloendotheliosis

Aliases & Descriptions for Reticuloendotheliosis:

Name: Reticuloendotheliosis 50 52
Reticuloendotheliosis, X-Linked 50 69

Characteristics:

HPO:

32
reticuloendotheliosis:
Inheritance x-linked inheritance
Onset and clinical course infantile onset


Classifications:



Summaries for Reticuloendotheliosis

MalaCards based summary : Reticuloendotheliosis, also known as reticuloendotheliosis, x-linked, is related to intrapelvic lymph node leukemic reticuloendotheliosis and histoplasmosis, and has symptoms including jaundice, hepatosplenomegaly and anemia. An important gene associated with Reticuloendotheliosis is REL (REL Proto-Oncogene, NF-KB Subunit), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and TNFR1 Pathway. Affiliated tissues include lung, and related phenotypes are liver/biliary system and respiratory system

Wikipedia : 71 Histoplasmosis (also known as \"Cave disease,\" \"Darling\'s disease,\" \"Ohio valley disease,\"... more...

Related Diseases for Reticuloendotheliosis

Diseases related to Reticuloendotheliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
id Related Disease Score Top Affiliating Genes
1 intrapelvic lymph node leukemic reticuloendotheliosis 11.9
2 histoplasmosis 11.4
3 omenn syndrome 11.0
4 hairy cell leukemia 11.0
5 hemophagocytic lymphohistiocytosis, familial, 1 10.8
6 letterer-siwe disease 10.3
7 eosinophilic granuloma 9.9
8 laryngotracheitis 9.8
9 lymphosarcoma 9.8
10 follicular mucinosis 9.8
11 retinopathy, arteriosclerotic 9.2 JARID2 LOC100422456 REL RELA RELB

Graphical network of the top 20 diseases related to Reticuloendotheliosis:



Diseases related to Reticuloendotheliosis

Symptoms & Phenotypes for Reticuloendotheliosis

Human phenotypes related to Reticuloendotheliosis:

32
id Description HPO Frequency HPO Source Accession
1 jaundice 32 HP:0000952
2 hepatosplenomegaly 32 HP:0001433
3 anemia 32 HP:0001903
4 lymphadenopathy 32 HP:0002716

MGI Mouse Phenotypes related to Reticuloendotheliosis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.26 JARID2 REL RELA RELB
2 respiratory system MP:0005388 8.92 JARID2 REL RELA RELB

Drugs & Therapeutics for Reticuloendotheliosis

Search Clinical Trials , NIH Clinical Center for Reticuloendotheliosis

Genetic Tests for Reticuloendotheliosis

Anatomical Context for Reticuloendotheliosis

MalaCards organs/tissues related to Reticuloendotheliosis:

39
Lung

Publications for Reticuloendotheliosis

Articles related to Reticuloendotheliosis:

(show all 16)
id Title Authors Year
1
Reticuloendotheliosis virus strain T induces miR-155, which targets JARID2 and promotes cell survival. ( 19759154 )
2009
2
Orbital lymphosarcoma associated with reticuloendotheliosis virus in a peafowl. ( 9702227 )
1998
3
Effects of reticuloendotheliosis virus on the response of chickens to infectious laryngotracheitis virus. ( 18770210 )
1982
4
Familial reticuloendotheliosis with eosinophilia and follicular mucinosis. ( 4337378 )
1972
5
Apparent cure of Letterer-Siwe disease. Seventeen-year survival of identical twins with nonlipoid reticuloendotheliosis. ( 5952210 )
1966
6
Congenital Letterer-Siwe disease (reticuloendotheliosis) in a term stillborn infant. ( 13681769 )
1960
7
The course and prognosis of reticuloendotheliosis (eosinophilic granuloma, SchA1ller-Christian disease and Letterer-Siwe disease); a study of forty cases. ( 13410955 )
1957
8
Recovery from acute infantile non-lipoid reticuloendotheliosis (Letterer-Siwe disease). ( 13228048 )
1954
9
Malignant reticuloendotheliosis (Letterer-Siwe disease); report of case with normocholesteremic lipid granulomatosis and eosinophilic granuloma. ( 13137595 )
1954
10
Systemic reticuloendotheliosis (Letterer-Siwe disease) in the adult male. ( 13181289 )
1954
11
The ameliorative effect of antibiotics on nonlipoid reticuloendotheliosis (Letterer-Siwe disease) in identical twins. ( 14908834 )
1952
12
Acute reticuloendotheliosis (Letterer-Siwe disease); report of a case in which several unusual features are combined. ( 14902100 )
1952
13
Familial incidence of non-lipoid reticuloendotheliosis (Letterer-Siwe disease). ( 14904103 )
1951
14
Nonlipid reticuloendotheliosis; Letterer-Siwe disease; report of a case. ( 18149231 )
1949
15
Systemic aleukemic reticuloendotheliosis; Letterer-Siwe disease. ( 18882062 )
1948
16
Reticuloendotheliosis (Letterer-Siwe disease). ( 20251575 )
1947

Variations for Reticuloendotheliosis

Expression for Reticuloendotheliosis

Search GEO for disease gene expression data for Reticuloendotheliosis.

Pathways for Reticuloendotheliosis

Pathways related to Reticuloendotheliosis according to GeneCards Suite gene sharing:

(show all 42)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 REL RELA RELB
2
Show member pathways
12.63 REL RELA RELB
3
Show member pathways
12.49 REL RELA RELB
4
Show member pathways
12.46 REL RELA RELB
5
Show member pathways
12.4 REL RELA RELB
6
Show member pathways
12.37 REL RELA RELB
7
Show member pathways
12.36 REL RELA RELB
8
Show member pathways
12.33 REL RELA RELB
9 12.32 REL RELA RELB
10
Show member pathways
12.21 REL RELA RELB
11
Show member pathways
12.2 REL RELA RELB
12
Show member pathways
12.14 REL RELA RELB
13
Show member pathways
12.13 REL RELA RELB
14
Show member pathways
12.07 REL RELA RELB
15
Show member pathways
12.01 REL RELA RELB
16
Show member pathways
12 REL RELA RELB
17
Show member pathways
11.98 REL RELA RELB
18
Show member pathways
11.92 REL RELA RELB
19
Show member pathways
11.84 REL RELA RELB
20 11.79 RELA RELB
21
Show member pathways
11.79 REL RELA RELB
22 11.72 REL RELA RELB
23
Show member pathways
11.68 REL RELA RELB
24 11.66 RELA RELB
25
Show member pathways
11.66 REL RELA RELB
26
Show member pathways
11.6 RELA RELB
27
Show member pathways
11.53 REL RELA RELB
28 11.52 REL RELA RELB
29 11.51 REL RELA RELB
30
Show member pathways
11.43 REL RELA RELB
31 11.38 REL RELA RELB
32
Show member pathways
11.36 REL RELA
33
Show member pathways
11.31 REL RELA RELB
34 11.28 REL RELA RELB
35 11.14 REL RELA RELB
36 11.08 REL RELA RELB
37
Show member pathways
11.01 REL RELA RELB
38 10.98 RELA RELB
39 10.94 REL RELA RELB
40 10.74 REL RELA
41 10.65 REL RELA RELB
42 10.55 JARID2 REL RELA RELB

GO Terms for Reticuloendotheliosis

Cellular components related to Reticuloendotheliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 I-kappaB/NF-kappaB complex GO:0033256 8.8 REL RELA RELB

Biological processes related to Reticuloendotheliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription, DNA-templated GO:0045892 9.58 JARID2 RELA RELB
2 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.46 RELA RELB
3 negative regulation of transcription from RNA polymerase II promoter GO:0000122 9.46 JARID2 REL RELA RELB
4 liver development GO:0001889 9.43 JARID2 RELA
5 inflammatory response GO:0006954 9.43 REL RELA RELB
6 NIK/NF-kappaB signaling GO:0038061 9.37 REL RELB
7 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.32 REL RELB
8 negative regulation of interferon-beta production GO:0032688 8.96 REL RELB
9 response to cytokine GO:0034097 8.8 REL RELA RELB

Molecular functions related to Reticuloendotheliosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.62 JARID2 REL RELA RELB
2 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.26 REL RELA
3 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0001205 9.16 REL RELA
4 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 9.13 JARID2 RELA RELB
5 chromatin binding GO:0003682 8.92 JARID2 REL RELA RELB

Sources for Reticuloendotheliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
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48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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