MCID: RTC005
MIFTS: 42

Reticulosarcoma malady

Immune diseases category

Summaries for Reticulosarcoma

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46OMIM, 32MalaCards
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MalaCards: Reticulosarcoma, also known as diffuse large b-cell lymphoma, is related to anaplastic large cell lymphoma and lymphosarcoma. An important gene associated with Reticulosarcoma is LTK (leukocyte receptor tyrosine kinase), and among its related pathways is Lymphocyte Signaling. The compounds doxorubicin and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and bone, and related mouse phenotype mortality/aging.

Description from OMIM:46 267730

Aliases & Classifications for Reticulosarcoma

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

reticulosarcoma 8 10 60
diffuse large b-cell lymphoma 60
large-cell lymphomas 8
histiocytic lymphoma 8
lymphoma, large-cell 42
lymphoma large cell 44
large cell lymphoma 42


Related Diseases for Reticulosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Reticulosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.1GZMB, TNFRSF8, NPM1, BCL6, ALK, TPM3
2lymphosarcoma30.6BCL6, TNFRSF8
3myeloid leukemia30.4NPM1
4histiocytosis30.4LYZ
5cutaneous t cell lymphoma30.4TNFRSF8, GZMB, TIA1
6malignant histiocytosis30.4TNFRSF8
7hemophagocytic lymphohistiocytosis30.3GZMB, NCAM1
8mycosis fungoides30.3TIA1, GZMB, TNFRSF8
9burkitt's lymphoma30.3TNFRSF8, BCL6, ALK
10non-hodgkin lymphoma30.3GZMB, TNFRSF8, NPM1, BCL6, ALK
11panniculitis30.2TIA1
12sarcoma30.2LYZ, ALK
13lymphoma, diffuse large cell30.2TNFRSF8, BCL6
14hepatitis30.1GZMB
15hodgkin's lymphoma30.1TIA1, GZMB, TNFRSF8, BCL6, ALK
16lung cancer30.0GZMB, NPM1, NCAM1, FUT4, ALK
17leukemia29.8TIA1, GZMB, NPM1, NCAM1, FUT4, BCL6
18breast lymphoma10.8
19hepatitis b10.7
20pediatric lymphoma10.7
21lymphoplasmacytic lymphoma10.6
22adult lymphoma10.6
23diffuse large b-cell lymphoma10.6
24neutropenia10.6
25diffuse large b-cell lymphoma of the central nervous system10.6
26diffuse large b-cell lymphoma with chronic inflammation10.6
27central nervous system lymphoma10.5
28pure red-cell aplasia10.5
29thyroid lymphoma10.5
30hypercalcemia10.5
31b cell deficiency10.5
32gray zone lymphoma10.5
33ophthalmoplegia10.5
34primary cutaneous diffuse large b-cell lymphoma, leg type10.5
35epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.5
36large cell carcinoma10.5
37lung lymphoma10.4
38alk-negative anaplastic large cell lymphoma10.4
39alk-positive anaplastic large cell lymphoma10.4
40ataxia telangiectasia10.4
41common variable immunodeficiency10.4
42prostate lymphoma10.4
43gastric adenocarcinoma10.4
44gastric diffuse adenocarcinoma10.4
45prostatitis10.4
46alk-positive large b-cell lymphoma10.4
47t-cell leukemia10.4
48breast reconstruction10.3
49gastrointestinal lymphoma10.3
50bladder lymphoma10.3

Graphical network of the top 20 diseases related to Reticulosarcoma:



Diseases related to reticulosarcoma

Clinical Features for Reticulosarcoma

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46OMIM
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Clinical features from OMIM:

267730

Drugs & Therapeutics for Reticulosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Reticulosarcoma

Genetic Tests for Reticulosarcoma

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Anatomical Context for Reticulosarcoma

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32MalaCards
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MalaCards organs/tissues related to Reticulosarcoma:

32
B cells, Thyroid, Bone, Liver, Monocytes, Tonsil, Breast, Lung, Kidney, Eye, Bone marrow

Animal Models for Reticulosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Reticulosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.3TPM3, BCL6, PTGES3, DACH1, FGF19, NCAM1

Publications for Reticulosarcoma

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50PubMed
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Articles related to Reticulosarcoma:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. (11426330)
2001
2
Treatment and prophylaxis of experimental liver metastases of M5076 reticulosarcoma with cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) encapsulated in multilamellar vesicles. (3315188)
1987
3
Ultrastructural and freeze fracture localization of multilamellar liposomes containing a lipophilic cisplatin analogue in normal tissues and liver metastases of M5076 reticulosarcoma. (3322541)
1987
4
Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. (3100032)
1987
5
Round-cell sarcomas of bone and their differential diagnosis (with particular emphasis on Ewing's sarcoma and reticulosarcoma). A study of 233 tumors with optical and electron microscopic techniques. (6763672)
1982
6
Morphology of lymphoreticular tissues in mice with reticulosarcoma. (365565)
1978
7
Combination chemotherapy with adriamycine, VM 26, cyclophosphamide and prednisone in lymphosarcoma and reticulosarcoma stage III and IV. (326554)
1977
8
Adult coeliac disease. A case with ulceration, dermatitis herpetiformis and reticulosarcoma. (766153)
1976
9
Pathogenesis of ascites in a murine transplantable reticulosarcoma type A. (137595)
1976
10
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
11
Microglioma and/or reticulosarcoma of the nervous system. (51573)
1975
12
Reticulosarcoma occurring during long-term hemodialysis. (1092500)
1975
13
Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. II. Reticulosarcoma. (Correlation with the immunity reaction of the cellular type and the clinical status). (4573872)
1973
14
Blastoid lymphocyte transformation assay in malignant tumours of lymphopoietic tissue: in Hodgkin's disease, reticulosarcoma, lymphosarcoma and chronic lymphatic leukaemia. Relationship to the clinical status and to the delayed type of hypersensitivity. (4128515)
1973
15
Reticulosarcoma of the vulva complicating dermatomyositis treated by immunosuppression. (4577331)
1973
16
Reticulosarcoma of vulva complicating azathioprine-treated dermatomyositis. (4583173)
1973
17
Cytologic studies of tumors. L. clonal proliferation of four stemlines in three hematopoietic tissues of a patient with reticulosarcoma. (4925076)
1971
18
Reticulosarcoma of the stomach. Report of 13 cases with follow-up results. (4931920)
1970
19
Cytogenetic analysis in two cases of lymphoma. Comparison between lymphosarcoma and reticulosarcoma. (4910257)
1970
20
Electron microscopic study of tonsillar reticulosarcoma. I. Features of malignancy in tumor cells. (4886966)
1967
21
Reticulosarcoma of the caecum. (5337477)
1967
22
Reticulosarcoma of the eye treated with cyclophosphamide. (5336275)
1966
23
DISSEMINATED HISTOPLASMOSIS FOLLOWING LONG-TERM STEROID THERAPY FOR RETICULOSARCOMA. (14331625)
1965
24
INTESTINAL RETICULOSARCOMA IN IDIOPATHIC STEATORRHOEA. (14273509)
1964
25
ACQUIRED HYPOGAMMAGLOBULINAEMIA COMPLICATED BY RETICULOSARCOMA. (14098564)
1963
26
Primary reticulosarcoma of the thyroid gland. (13742171)
1961
27
Malignant tumours of the stomach arising from the lympho-reticular system. A report of 10 cases of lymphosarcoma and reticulosarcoma of the stomach. (14492653)
1961
28
Reticulosarcoma complicating sarcoidosis. (13805580)
1960
29
Reticulosarcoma of both breasts. (13835234)
1959
30
Perforating reticulosarcoma of the jejunum. (14420016)
1959
31
Studies on the therapy of reticulosarcoma(-tosis) with actinomycin. (14445951)
1959
32
Chemotherapeutic management of reticulosarcoma. (14441246)
1959
33
Reticulosarcoma. (13653789)
1959
34
Unusual evolutive aspects of the histological picture and systemic characteristics of reticulosarcoma of the tonsils]. (13436161)
1957
35
Reticulosarcoma in Hashimoto's disease. (13510630)
1957
36
Reticulosarcoma of the thyroid gland (struma reticulosa). (13270181)
1955
37
Reticulosarcoma of the caecum. (13242834)
1955
38
A case of reticulosarcoma (reticulum-cell sarcoma) of bone. (13190202)
1954
39
Some connective tissue diseases (amyloidosis, arthritis, reticulosarcoma) in the baboon (Papio ursinus). (13238076)
1954
40
The cytologic diagnosis of duodenal sarcoma; polymorphic reticulosarcoma. (13105202)
1953
41
Multiple reticulosarcoma of the duodenum and jejunum. (13082015)
1953
42
The diagnosis of reticulosarcoma of the thyroid gland. (14938460)
1952
43
Gastro-pleural fistula: review of the literature with a report of a case due to reticulosarcoma of the stomach. (14937225)
1952
44
Reticulosarcoma of the thyroid gland. (14895948)
1951
45
Experimental studies on reticulosarcoma. (14820984)
1951
46
An autopsy case of myelogenic reticulosarcoma with marked osteoplasia [Japanese text]. (14906572)
1951
47
Reticulosarcoma; eosinophilic granuloma. (15430342)
1950
48
Reticulosarcoma of the thyroid gland. (15392482)
1949
49
A case of reticulosarcoma. (20277624)
1946
50
Report of a Case of Retotheliosarcoma (Reticulosarcoma) of the Cerebral Hemisphere. (19970053)
1933

Genetic Variations for Reticulosarcoma

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Expression for genes affiliated with Reticulosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticulosarcoma

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Pathways for genes affiliated with Reticulosarcoma

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4Cell Signaling Technology
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Pathways related to Reticulosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BCL6, NCAM1, GZMB

Compounds for genes affiliated with Reticulosarcoma

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Reticulosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1doxorubicin44 49 1110.9ALK, BCL6, NCAM1, NPM1
2[alcl]448.4ALK, NPM1, TNFRSF8, GZMB, TIA1
3lactate448.3GZMB, NPM1, NCAM1, BCL6, ALK
4paraffin447.6TIA1, GZMB, TNFRSF8, NPM1, NCAM1, BCL6
5tyrosine447.2GZMB, TNFRSF8, NPM1, NCAM1, LTK, BCL6

GO Terms for genes affiliated with Reticulosarcoma

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16Gene Ontology
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Biological processes related to Reticulosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytolysisGO:01983510.0LYZ, GZMB

Products for genes affiliated with Reticulosarcoma

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Sources for Reticulosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet