MCID: RTC005
MIFTS: 40

Reticulosarcoma malady

Immune category

Summaries for Reticulosarcoma

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47OMIM, 33MalaCards
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MalaCards: Reticulosarcoma, also known as diffuse large b-cell lymphoma, is related to anaplastic large cell lymphoma and lymphoma, diffuse large cell. An important gene associated with Reticulosarcoma is LTK (leukocyte receptor tyrosine kinase), and among its related pathways is Lymphocyte Signaling. The compounds doxorubicin and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and lung, and related mouse phenotype mortality/aging.

Description from OMIM:47 267730

Aliases & Classifications for Reticulosarcoma

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 43NIH Rare Diseases, 45Novoseek, 57SNOMED-CT, 47OMIM, 35MeSH, 27ICD9CM, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune


Aliases & Descriptions:

reticulosarcoma 8 10 61
diffuse large b-cell lymphoma 61
large-cell lymphomas 8
histiocytic lymphoma 8
lymphoma, large-cell 43
large cell lymphoma 43
lymphoma large cell 45


Related Diseases for Reticulosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Reticulosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.2NPM1, ALK, BCL6, TNFRSF8, TPM3, GZMB
2lymphoma, diffuse large cell31.3TNFRSF8, BCL6
3lymphomatoid papulosis31.1ALK, GZMB, TNFRSF8, TIA1, NPM1
4lymphosarcoma30.7TNFRSF8, BCL6
5peripheral t-cell lymphoma30.6BCL6, GZMB, TNFRSF8, NCAM1, TIA1, ALK
6malignant histiocytosis30.5TNFRSF8
7hemophagocytic lymphohistiocytosis30.4GZMB, NCAM1
8mycosis fungoides30.4TIA1, TNFRSF8, GZMB
9angioimmunoblastic t-cell lymphoma30.0BCL6
10burkitt's lymphoma30.0BCL6, TNFRSF8, ALK
11b-cell lymphomas29.9NPM1, ALK, BCL6, TIA1, TNFRSF8, GZMB
12primary cutaneous anaplastic large cell lymphoma11.0
13breast lymphoma10.8
14pediatric lymphoma10.7
15hepatitis d10.7
16lymphoplasmacytic lymphoma10.7
17anaplastic small cell lymphoma10.6
18adult lymphoma10.6
19follicular lymphoma10.6
20nodular lymphocyte predominant hodgkin lymphoma10.6
21diffuse large b-cell lymphoma10.6
22central nervous system lymphoma10.5
23thyroid lymphoma10.5
24hypercalcemia10.5
25cold agglutinin disease10.5
26diffuse large b-cell lymphoma of the central nervous system10.5
27large cell carcinoma10.5
28lung lymphoma10.5
29n syndrome10.5
30alk-negative anaplastic large cell lymphoma10.5
31ataxia telangiectasia10.4
32common variable immunodeficiency10.4
33hepatitis b10.4
34ataxia10.4
35follicular lymphoma 110.4
36lymphoplasmacytoid lymphoma10.4
37primary cutaneous diffuse large b-cell lymphoma, leg type10.4
38epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.4
39diffuse large b-cell lymphoma with chronic inflammation10.4
40t-cell prolymphocytic leukemia10.4
41colon lymphoma10.4
42alk-positive anaplastic large cell lymphoma10.4
43histiocytic sarcoma10.3
44gastrointestinal lymphoma10.3
45bladder lymphoma10.3
46t-cell leukemia10.3
47central nervous system lymphoma, primary10.3
48inflammatory myofibroblastic tumor10.3
49leukemia/lymphoma, t-cell10.3
50intravascular large b-cell lymphoma10.3

Graphical network of the top 20 diseases related to Reticulosarcoma:



Diseases related to reticulosarcoma

Clinical Features for Reticulosarcoma

Sources:
47OMIM
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Clinical features from OMIM:

267730

Drugs & Therapeutics for Reticulosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Reticulosarcoma

Drug clinical trials:

Search ClinicalTrials for Reticulosarcoma

Search NIH Clinical Center for Reticulosarcoma

Search CenterWatch for Reticulosarcoma

Genetic Tests for Reticulosarcoma

Anatomical Context for Reticulosarcoma

Sources:
33MalaCards
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MalaCards organs/tissues related to Reticulosarcoma:

33
Liver, Kidney, Lung, Bone marrow, Thyroid, Breast, Tonsil, Monocytes, B cells

Animal Models for Reticulosarcoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Reticulosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.3TPM3, BCL6, PTGES3, DACH1, FGF19, NCAM1

Publications for Reticulosarcoma

Sources:
51PubMed
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Articles related to Reticulosarcoma:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. (11426330)
2001
2
In vitro and in vivo characterisation of low-resistant mouse reticulosarcoma (M5076) sublines obtained after pulse and continuous exposure to cisplatin. (8943689)
1996
3
Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice. (2189589)
1990
4
Ultrastructural and freeze fracture localization of multilamellar liposomes containing a lipophilic cisplatin analogue in normal tissues and liver metastases of M5076 reticulosarcoma. (3322541)
1987
5
Primary reticulosarcoma of bone (non-Hodgkin's lymphoma). A study of 12 cases. (3503874)
1987
6
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
7
Preliminary results of chemoradiotherapy followed (or not ) by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma: correlation of the results with WHO categorization. (370939)
1978
8
Preliminary results of chemo-radiotherapy followed or not by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma. Correlation of the results with WHO categorisation. (373920)
1978
9
Malignant lymphoma (reticulosarcoma) in bone. (334431)
1977
10
Modifications of macrophage chemotaxis in rats bearing the transplantable tumour reticulosarcoma 'IRE'. (335481)
1977
11
Adult coeliac disease. A case with ulceration, dermatitis herpetiformis and reticulosarcoma. (766153)
1976
12
The effect of immunostimulation and chemotherapy on the growth of reticulosarcoma in mice. (4618487)
1974
13
Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. II. Reticulosarcoma. (Correlation with the immunity reaction of the cellular type and the clinical status). (4573872)
1973
14
Reticulosarcoma of vulva complicating azathioprine-treated dermatomyositis. (4583173)
1973
15
Lambda cold agglutinin with anti-A 1 specificity in a patient with reticulosarcoma. (4622181)
1972
16
Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. (4941118)
1971
17
Reticulosarcoma of the stomach. Report of 13 cases with follow-up results. (4931920)
1970
18
Primary cerebral reticulosarcoma. (4913659)
1970
19
Cytogenetic analysis in two cases of lymphoma. Comparison between lymphosarcoma and reticulosarcoma. (4910257)
1970
20
Electron microscopic study of tonsillar reticulosarcoma. II. Effect of radiation on tumor cells. (4886967)
1967
21
Reticulosarcoma of the caecum. (5337477)
1967
22
Reticulosarcoma of the eye treated with cyclophosphamide. (5336275)
1966
23
LYMPHOGRAPHY WITH RADIOACTIVE CONTRAST MEDIUM IN LYMPHOSARCOMA AND RETICULOSARCOMA. (14247471)
1965
24
Case of Mesenteric Reticulosarcoma Associated with Gluten-sensitive Steatorrhoea. (20789212)
1961
25
Reticulosarcoma complicating sarcoidosis. (13805580)
1960
26
Trypan blue concentration and protein composition in sera of rats injected repeatedly with Trypan blue in relation to reticulosis and to reticulosarcoma. (13722875)
1960
27
Reticulosarcoma of both breasts. (13835234)
1959
28
Perforating reticulosarcoma of the jejunum. (14420016)
1959
29
A case of "malignant granuloma of the nose"; reticulosarcoma]. (13670636)
1959
30
Studies on the therapy of reticulosarcoma(-tosis) with actinomycin. (14445951)
1959
31
The mechanical resistance of white blood cells in lymphosarcoma, reticulosarcoma and malignant lymphogranuloma: a contribution to the differential diagnosis and to the knowledge of the biologic behaviour of leukocytes in human pathology. (13798549)
1959
32
Chemotherapeutic management of reticulosarcoma. (14441246)
1959
33
Reticulosarcoma. (13653789)
1959
34
Establishment of two human cell strains from kidney and reticulosarcoma in lung. (13545791)
1958
35
Unusual evolutive aspects of the histological picture and systemic characteristics of reticulosarcoma of the tonsils]. (13436161)
1957
36
Reticulosarcoma in Hashimoto's disease. (13510630)
1957
37
Studies on therapy of reticulosarcoma (-tosis) with actinomycin. (13415074)
1956
38
Reticulosarcoma of the thyroid gland and stomach. (13293343)
1956
39
Reticulosarcoma of the caecum. (13242834)
1955
40
Some connective tissue diseases (amyloidosis, arthritis, reticulosarcoma) in the baboon (Papio ursinus). (13238076)
1954
41
Intercurrent infection with toxoplasma: organisms found in the bone marrow of a patient with advanced reticulosarcoma. (13223095)
1954
42
The cytologic diagnosis of duodenal sarcoma; polymorphic reticulosarcoma. (13105202)
1953
43
The diagnosis of reticulosarcoma of the thyroid gland. (14938460)
1952
44
Gastro-pleural fistula: review of the literature with a report of a case due to reticulosarcoma of the stomach. (14937225)
1952
45
Cytological studies on reticulosarcoma I. [Japanese text]. (14906538)
1951
46
Reticulosarcoma of the thyroid gland. (14895948)
1951
47
An autopsy case of myelogenic reticulosarcoma with marked osteoplasia [Japanese text]. (14906572)
1951
48
Reticulosarcoma of the thyroid gland. (15392482)
1949
49
A case of reticulosarcoma. (20277624)
1946
50
Dictyocytic Reticulosarcoma. (19992036)
1939

Genetic Variations for Reticulosarcoma

Expression for genes affiliated with Reticulosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticulosarcoma

Search GEO for disease gene expression data for Reticulosarcoma.

Pathways for genes affiliated with Reticulosarcoma

Sources:
4Cell Signaling Technology
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Pathways related to Reticulosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BCL6, NCAM1, GZMB

Compounds for genes affiliated with Reticulosarcoma

Sources:
45Novoseek, 50PharmGKB, 11DrugBank
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Compounds related to Reticulosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1doxorubicin45 50 1110.9ALK, BCL6, NCAM1, NPM1
2[alcl]458.4ALK, NPM1, TNFRSF8, GZMB, TIA1
3lactate458.3GZMB, NPM1, NCAM1, BCL6, ALK
4paraffin457.6TIA1, GZMB, TNFRSF8, NPM1, NCAM1, BCL6
5tyrosine457.2GZMB, TNFRSF8, NPM1, NCAM1, LTK, BCL6

GO Terms for genes affiliated with Reticulosarcoma

Sources:
16Gene Ontology
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Biological processes related to Reticulosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytolysisGO:01983510.0LYZ, GZMB

Products for genes affiliated with Reticulosarcoma

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  • Lysates
  • Antibodies

Sources for Reticulosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet