MCID: RTC005
MIFTS: 43

Reticulosarcoma malady

Rare diseases, Cancer diseases, Immune diseases categories
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Summaries for Reticulosarcoma

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47OMIM, 33MalaCards
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MalaCards: Reticulosarcoma, also known as diffuse large b-cell lymphoma, is related to anaplastic large cell lymphoma and lymphomatoid papulosis. An important gene associated with Reticulosarcoma is LYZ (lysozyme), and among its related pathways are Tyrosine Kinases / Adaptors and Akt Signaling. The compounds [alcl] and doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and bone.

Description from OMIM:47 267730

Aliases & Classifications for Reticulosarcoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 27ICD9CM, 58SNOMED-CT, 47OMIM, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Immune diseases


Aliases & Descriptions:

reticulosarcoma 8 10 62
diffuse large b-cell lymphoma 62
large-cell lymphomas 8
histiocytic lymphoma 8
lymphoma, large-cell 43
lymphoma large cell 45
large cell lymphoma 43


Related Diseases for Reticulosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Reticulosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 188)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.0TNFRSF8, TPM3, BCL6, ALK, NPM1
2lymphomatoid papulosis31.0NPM1, ALK, TIA1, TNFRSF8
3lymphosarcoma30.7TNFRSF8, BCL6
4b-cell lymphomas30.6TNFRSF8, TIA1, BCL6, ALK, NPM1
5peripheral t-cell lymphoma30.5ALK, BCL6, TIA1, TNFRSF8
6lymphoma, diffuse large cell30.4TNFRSF8, BCL6
7mycosis fungoides30.4TIA1, TNFRSF8
8burkitt's lymphoma30.2ALK, BCL6, TNFRSF8
9hodgkin's lymphoma30.1ALK, BCL6, TIA1, TNFRSF8
10b-cell chronic lymphocytic leukemia30.1TNFRSF8, BCL6
11myeloma30.0ALK, BCL6, TNFRSF8
12leukemia29.8TIA1, LYZ, BCL6, ALK, NPM1
13alk-positive anaplastic large cell lymphoma11.0
14primary cutaneous anaplastic large cell lymphoma11.0
15alk-negative anaplastic large cell lymphoma10.8
16follicular lymphoma10.5
17thyroiditis10.4
18malignant histiocytosis10.4
19histiocytosis10.4
20diffuse large b-cell lymphoma10.4
21mediastinitis10.4
22myeloid leukemia10.4
23inflammatory myofibroblastic tumor10.4
24acquired immunodeficiency syndrome10.3
25adult t-cell leukemia10.3
26t-cell leukemia10.3
27soft tissue sarcoma10.3
28sarcoma10.2
29acute monocytic leukemia10.2
30richter's syndrome10.2
31chronic lymphocytic leukemia10.2
32histiocytic sarcoma10.2
33burn scar10.2
34burns10.2
35chronic myeloid leukemia10.2
36hemophagocytic lymphohistiocytosis10.2
37acute myeloid leukemia10.2
38wiskott-aldrich syndrome10.2
39lymphoepithelioma-like carcinoma10.2
40capillary leak syndrome10.2
41eosinophilia10.2
42panniculitis10.2
43syphilis10.2
44vasculitis10.2
45tetraploidy10.2
46endotheliitis10.2
47primary mediastinal large b-cell lymphoma10.2
48intravascular large b-cell lymphoma10.2
49cerebritis10.1
50dermatomyositis10.1

Graphical network of the top 20 diseases related to Reticulosarcoma:



Diseases related to reticulosarcoma

Symptoms for Reticulosarcoma

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47OMIM
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Clinical features from OMIM:

267730

Drugs & Therapeutics for Reticulosarcoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Reticulosarcoma

Search NIH Clinical Center for Reticulosarcoma

Genetic Tests for Reticulosarcoma

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Anatomical Context for Reticulosarcoma

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33MalaCards
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MalaCards organs/tissues related to Reticulosarcoma:

33
B cells, Thyroid, Bone, Liver, Monocytes, Tonsil, Breast, Lung, Kidney, Eye, Bone marrow

Animal Models for Reticulosarcoma or affiliated genes

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Publications for Reticulosarcoma

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52PubMed
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Articles related to Reticulosarcoma:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Intravenous injection of oligodeoxynucleotides to the NF-kappaB binding site inhibits hepatic metastasis of M5076 reticulosarcoma in mice. (11426330)
2001
2
Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice. (2189589)
1990
3
Treatment and prophylaxis of experimental liver metastases of M5076 reticulosarcoma with cis-bis-neodecanoato-trans-R,R-1,2-diaminocyclohexaneplatinum (II) encapsulated in multilamellar vesicles. (3315188)
1987
4
Ultrastructural and freeze fracture localization of multilamellar liposomes containing a lipophilic cisplatin analogue in normal tissues and liver metastases of M5076 reticulosarcoma. (3322541)
1987
5
Primary reticulosarcoma of bone (non-Hodgkin's lymphoma). A study of 12 cases. (3503874)
1987
6
Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. (3100032)
1987
7
Round-cell sarcomas of bone and their differential diagnosis (with particular emphasis on Ewing's sarcoma and reticulosarcoma). A study of 233 tumors with optical and electron microscopic techniques. (6763672)
1982
8
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
9
Preliminary results of chemoradiotherapy followed (or not ) by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma: correlation of the results with WHO categorization. (370939)
1978
10
Preliminary results of chemo-radiotherapy followed or not by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma. Correlation of the results with WHO categorisation. (373920)
1978
11
Malignant lymphoma (reticulosarcoma) in bone. (334431)
1977
12
Combination chemotherapy with adriamycine, VM 26, cyclophosphamide and prednisone in lymphosarcoma and reticulosarcoma stage III and IV. (326554)
1977
13
Adult coeliac disease. A case with ulceration, dermatitis herpetiformis and reticulosarcoma. (766153)
1976
14
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
15
Microglioma and/or reticulosarcoma of the nervous system. (51573)
1975
16
Reticulosarcoma occurring during long-term hemodialysis. (1092500)
1975
17
Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. II. Reticulosarcoma. (Correlation with the immunity reaction of the cellular type and the clinical status). (4573872)
1973
18
Reticulosarcoma of the vulva complicating dermatomyositis treated by immunosuppression. (4577331)
1973
19
Lambda cold agglutinin with anti-A 1 specificity in a patient with reticulosarcoma. (4622181)
1972
20
Cytologic studies of tumors. L. clonal proliferation of four stemlines in three hematopoietic tissues of a patient with reticulosarcoma. (4925076)
1971
21
Reticulosarcoma of the stomach. Report of 13 cases with follow-up results. (4931920)
1970
22
Primary cerebral reticulosarcoma. (4913659)
1970
23
Cytogenetic analysis in two cases of lymphoma. Comparison between lymphosarcoma and reticulosarcoma. (4910257)
1970
24
Electron microscopic study of tonsillar reticulosarcoma. II. Effect of radiation on tumor cells. (4886967)
1967
25
Electron microscopic study of tonsillar reticulosarcoma. I. Features of malignancy in tumor cells. (4886966)
1967
26
Reticulosarcoma of the caecum. (5337477)
1967
27
Reticulosarcoma of the eye treated with cyclophosphamide. (5336275)
1966
28
LYMPHOGRAPHY WITH RADIOACTIVE CONTRAST MEDIUM IN LYMPHOSARCOMA AND RETICULOSARCOMA. (14247471)
1965
29
DISSEMINATED HISTOPLASMOSIS FOLLOWING LONG-TERM STEROID THERAPY FOR RETICULOSARCOMA. (14331625)
1965
30
INTESTINAL RETICULOSARCOMA IN IDIOPATHIC STEATORRHOEA. (14273509)
1964
31
ACQUIRED HYPOGAMMAGLOBULINAEMIA COMPLICATED BY RETICULOSARCOMA. (14098564)
1963
32
Reticulosarcoma complicating sarcoidosis. (13805580)
1960
33
Reticulosarcoma of both breasts. (13835234)
1959
34
Perforating reticulosarcoma of the jejunum. (14420016)
1959
35
A case of "malignant granuloma of the nose"; reticulosarcoma]. (13670636)
1959
36
Studies on the therapy of reticulosarcoma(-tosis) with actinomycin. (14445951)
1959
37
The mechanical resistance of white blood cells in lymphosarcoma, reticulosarcoma and malignant lymphogranuloma: a contribution to the differential diagnosis and to the knowledge of the biologic behaviour of leukocytes in human pathology. (13798549)
1959
38
Unusual evolutive aspects of the histological picture and systemic characteristics of reticulosarcoma of the tonsils]. (13436161)
1957
39
Studies on therapy of reticulosarcoma (-tosis) with actinomycin. (13415074)
1956
40
Reticulosarcoma of the thyroid gland (struma reticulosa). (13270181)
1955
41
A case of reticulosarcoma (reticulum-cell sarcoma) of bone. (13190202)
1954
42
The cytologic diagnosis of duodenal sarcoma; polymorphic reticulosarcoma. (13105202)
1953
43
Multiple reticulosarcoma of the duodenum and jejunum. (13082015)
1953
44
The diagnosis of reticulosarcoma of the thyroid gland. (14938460)
1952
45
Gastro-pleural fistula: review of the literature with a report of a case due to reticulosarcoma of the stomach. (14937225)
1952
46
Cytological studies on reticulosarcoma I. [Japanese text]. (14906538)
1951
47
Reticulosarcoma of the thyroid gland. (15392482)
1949
48
A case of reticulosarcoma. (20277624)
1946
49
Dictyocytic Reticulosarcoma. (19992036)
1939
50
Report of a Case of Retotheliosarcoma (Reticulosarcoma) of the Cerebral Hemisphere. (19970053)
1933

Variations for Reticulosarcoma

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Expression for genes affiliated with Reticulosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticulosarcoma

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Pathways for genes affiliated with Reticulosarcoma

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50PathCards, 5Cell Signaling Technology, 53QIAGEN
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Pathways related to Reticulosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5NPM1, ALK
2
Show member pathways
8.8FGF19, ALK, TNFRSF8

Compounds for genes affiliated with Reticulosarcoma

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45Novoseek, 51PharmGKB, 11DrugBank
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Compounds related to Reticulosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1[alcl]458.7NPM1, ALK, TIA1, TNFRSF8
2doxorubicin45 51 1110.6NPM1, ALK, BCL6
3lactate458.4BCL6, ALK, NPM1
4serine458.2ALK, BCL6, TIA1, TNFRSF8
5paraffin457.8TNFRSF8, TIA1, BCL6, ALK, NPM1
6tyrosine457.7TNFRSF8, TPM3, BCL6, ALK, NPM1

GO Terms for genes affiliated with Reticulosarcoma

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16Gene Ontology
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Cellular components related to Reticulosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700628.7ALK, LYZ, TPM3, TNFRSF8

Biological processes related to Reticulosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of NF-kappaB transcription factor activityGO:0510929.5NPM1, ALK
2negative regulation of cell proliferationGO:0082858.4NPM1, BCL6, TNFRSF8

Products for genes affiliated with Reticulosarcoma

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Sources for Reticulosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet