MCID: RTC005
MIFTS: 42

Reticulosarcoma malady

Immune diseases category

Summaries for Reticulosarcoma

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46OMIM, 32MalaCards
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MalaCards: Reticulosarcoma, also known as diffuse large b-cell lymphoma, is related to anaplastic large cell lymphoma and lymphosarcoma. An important gene associated with Reticulosarcoma is LTK (leukocyte receptor tyrosine kinase), and among its related pathways is Lymphocyte Signaling. The compounds doxorubicin and [alcl] have been mentioned in the context of this disorder. Affiliated tissues include b cells, thyroid and bone, and related mouse phenotype mortality/aging.

Description from OMIM:46 267730

Aliases & Classifications for Reticulosarcoma

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8Disease Ontology, 10DISEASES, 60UMLS, 42NIH Rare Diseases, 44Novoseek, 56SNOMED-CT, 46OMIM, 34MeSH, 27ICD9CM, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Immune diseases


Aliases & Descriptions:

reticulosarcoma 8 10 60
diffuse large b-cell lymphoma 60
large-cell lymphomas 8
histiocytic lymphoma 8
lymphoma, large-cell 42
large cell lymphoma 42
lymphoma large cell 44


Related Diseases for Reticulosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Reticulosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 273)
idRelated DiseaseScoreTop Affiliating Genes
1anaplastic large cell lymphoma32.1GZMB, TNFRSF8, NPM1, BCL6, ALK, TPM3
2lymphosarcoma30.6BCL6, TNFRSF8
3myeloid leukemia30.4NPM1
4histiocytosis30.4LYZ
5cutaneous t cell lymphoma30.4TNFRSF8, GZMB, TIA1
6malignant histiocytosis30.4TNFRSF8
7hemophagocytic lymphohistiocytosis30.3GZMB, NCAM1
8mycosis fungoides30.3TIA1, GZMB, TNFRSF8
9burkitt's lymphoma30.3TNFRSF8, BCL6, ALK
10non-hodgkin lymphoma30.3GZMB, TNFRSF8, NPM1, BCL6, ALK
11panniculitis30.2TIA1
12sarcoma30.2LYZ, ALK
13lymphoma, diffuse large cell30.2TNFRSF8, BCL6
14hepatitis30.1GZMB
15hodgkin's lymphoma30.1TIA1, GZMB, TNFRSF8, BCL6, ALK
16lung cancer30.0GZMB, NPM1, NCAM1, FUT4, ALK
17leukemia29.8TIA1, GZMB, NPM1, NCAM1, FUT4, BCL6
18breast lymphoma10.8
19hepatitis b10.7
20pediatric lymphoma10.7
21lymphoplasmacytic lymphoma10.6
22adult lymphoma10.6
23diffuse large b-cell lymphoma10.6
24neutropenia10.6
25diffuse large b-cell lymphoma of the central nervous system10.6
26diffuse large b-cell lymphoma with chronic inflammation10.6
27central nervous system lymphoma10.5
28pure red-cell aplasia10.5
29thyroid lymphoma10.5
30hypercalcemia10.5
31b cell deficiency10.5
32gray zone lymphoma10.5
33ophthalmoplegia10.5
34primary cutaneous diffuse large b-cell lymphoma, leg type10.5
35epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly10.5
36large cell carcinoma10.5
37lung lymphoma10.4
38alk-negative anaplastic large cell lymphoma10.4
39alk-positive anaplastic large cell lymphoma10.4
40ataxia telangiectasia10.4
41common variable immunodeficiency10.4
42prostate lymphoma10.4
43gastric adenocarcinoma10.4
44gastric diffuse adenocarcinoma10.4
45prostatitis10.4
46alk-positive large b-cell lymphoma10.4
47t-cell leukemia10.4
48breast reconstruction10.3
49gastrointestinal lymphoma10.3
50bladder lymphoma10.3

Graphical network of the top 20 diseases related to Reticulosarcoma:



Diseases related to reticulosarcoma

Clinical Features for Reticulosarcoma

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46OMIM
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Clinical features from OMIM:

267730

Drugs & Therapeutics for Reticulosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Reticulosarcoma

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Anatomical Context for Reticulosarcoma

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32MalaCards
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MalaCards organs/tissues related to Reticulosarcoma:

32
B cells, Thyroid, Bone, Liver, Monocytes, Breast, Bone marrow, Lung, Eye, Kidney, Tonsil

Animal Models for Reticulosarcoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Reticulosarcoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.3TPM3, BCL6, PTGES3, DACH1, FGF19, NCAM1

Publications for Reticulosarcoma

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50PubMed
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Articles related to Reticulosarcoma:

(show top 50)    (show all 74)
idTitleAuthorsYear
1
In vitro and in vivo characterisation of low-resistant mouse reticulosarcoma (M5076) sublines obtained after pulse and continuous exposure to cisplatin. (8943689)
1996
2
Hepatic tissue distribution of doxorubicin-loaded nanoparticles after i.v. administration in reticulosarcoma M 5076 metastasis-bearing mice. (2189589)
1990
3
Primary reticulosarcoma of bone (non-Hodgkin's lymphoma). A study of 12 cases. (3503874)
1987
4
Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor. (3100032)
1987
5
Chemotherapists' need for uniform and rational nomenclature and classification of common lymphosarcomas and reticulosarcoma (hematosarcomas or non-Hodgkin's lymphomas). (373918)
1978
6
Preliminary results of chemoradiotherapy followed (or not ) by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma: correlation of the results with WHO categorization. (370939)
1978
7
Preliminary results of chemo-radiotherapy followed or not by active immunotherapy of stage III and IV lymphosarcoma and reticulosarcoma. Correlation of the results with WHO categorisation. (373920)
1978
8
Morphology of lymphoreticular tissues in mice with reticulosarcoma. (365565)
1978
9
Malignant lymphoma (reticulosarcoma) in bone. (334431)
1977
10
Modifications of macrophage chemotaxis in rats bearing the transplantable tumour reticulosarcoma 'IRE'. (335481)
1977
11
Adult coeliac disease. A case with ulceration, dermatitis herpetiformis and reticulosarcoma. (766153)
1976
12
Pathogenesis of ascites in a murine transplantable reticulosarcoma type A. (137595)
1976
13
Hairy cell leukemia ('leukemic reticuleondotheliosis'), reticulosarcoma, and monocytic leukemia. Cytochemical and ultrastructural investigations. (808067)
1975
14
Microglioma and/or reticulosarcoma of the nervous system. (51573)
1975
15
Reticulosarcoma occurring during long-term hemodialysis. (1092500)
1975
16
The effect of immunostimulation and chemotherapy on the growth of reticulosarcoma in mice. (4618487)
1974
17
Blastogenic transformation of lymphocytes following phytohaemagglutinin treatment in vitro in malignant lymphomas. II. Reticulosarcoma. (Correlation with the immunity reaction of the cellular type and the clinical status). (4573872)
1973
18
Blastoid lymphocyte transformation assay in malignant tumours of lymphopoietic tissue: in Hodgkin's disease, reticulosarcoma, lymphosarcoma and chronic lymphatic leukaemia. Relationship to the clinical status and to the delayed type of hypersensitivity. (4128515)
1973
19
Reticulosarcoma of the vulva complicating dermatomyositis treated by immunosuppression. (4577331)
1973
20
Reticulosarcoma of vulva complicating azathioprine-treated dermatomyositis. (4583173)
1973
21
Lambda cold agglutinin with anti-A 1 specificity in a patient with reticulosarcoma. (4622181)
1972
22
Cytologic studies of tumors. L. clonal proliferation of four stemlines in three hematopoietic tissues of a patient with reticulosarcoma. (4925076)
1971
23
Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors. (4941118)
1971
24
Reticulosarcoma of the stomach. Report of 13 cases with follow-up results. (4931920)
1970
25
Primary cerebral reticulosarcoma. (4913659)
1970
26
Electron microscopic study of tonsillar reticulosarcoma. II. Effect of radiation on tumor cells. (4886967)
1967
27
Electron microscopic study of tonsillar reticulosarcoma. I. Features of malignancy in tumor cells. (4886966)
1967
28
Reticulosarcoma of the eye treated with cyclophosphamide. (5336275)
1966
29
LYMPHOGRAPHY WITH RADIOACTIVE CONTRAST MEDIUM IN LYMPHOSARCOMA AND RETICULOSARCOMA. (14247471)
1965
30
DISSEMINATED HISTOPLASMOSIS FOLLOWING LONG-TERM STEROID THERAPY FOR RETICULOSARCOMA. (14331625)
1965
31
Case of Mesenteric Reticulosarcoma Associated with Gluten-sensitive Steatorrhoea. (20789212)
1961
32
Primary reticulosarcoma of the thyroid gland. (13742171)
1961
33
Trypan blue concentration and protein composition in sera of rats injected repeatedly with Trypan blue in relation to reticulosis and to reticulosarcoma. (13722875)
1960
34
A case of "malignant granuloma of the nose"; reticulosarcoma]. (13670636)
1959
35
Studies on the therapy of reticulosarcoma(-tosis) with actinomycin. (14445951)
1959
36
The mechanical resistance of white blood cells in lymphosarcoma, reticulosarcoma and malignant lymphogranuloma: a contribution to the differential diagnosis and to the knowledge of the biologic behaviour of leukocytes in human pathology. (13798549)
1959
37
Establishment of two human cell strains from kidney and reticulosarcoma in lung. (13545791)
1958
38
Studies on therapy of reticulosarcoma (-tosis) with actinomycin. (13415074)
1956
39
Reticulosarcoma of the thyroid gland and stomach. (13293343)
1956
40
Reticulosarcoma of the thyroid gland (struma reticulosa). (13270181)
1955
41
A case of reticulosarcoma (reticulum-cell sarcoma) of bone. (13190202)
1954
42
Intercurrent infection with toxoplasma: organisms found in the bone marrow of a patient with advanced reticulosarcoma. (13223095)
1954
43
Gastro-pleural fistula: review of the literature with a report of a case due to reticulosarcoma of the stomach. (14937225)
1952
44
Cytological studies on reticulosarcoma I. [Japanese text]. (14906538)
1951
45
Reticulosarcoma of the thyroid gland. (14895948)
1951
46
An autopsy case of myelogenic reticulosarcoma with marked osteoplasia [Japanese text]. (14906572)
1951
47
Reticulosarcoma; eosinophilic granuloma. (15430342)
1950
48
Reticulosarcoma of the thyroid gland. (15392482)
1949
49
A case of reticulosarcoma. (20277624)
1946
50
Dictyocytic Reticulosarcoma. (19992036)
1939

Genetic Variations for Reticulosarcoma

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Expression for genes affiliated with Reticulosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reticulosarcoma

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Pathways for genes affiliated with Reticulosarcoma

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4Cell Signaling Technology
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Pathways related to Reticulosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5BCL6, NCAM1, GZMB

Compounds for genes affiliated with Reticulosarcoma

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44Novoseek, 49PharmGKB, 11DrugBank
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Compounds related to Reticulosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1doxorubicin44 49 1110.9ALK, BCL6, NCAM1, NPM1
2[alcl]448.4ALK, NPM1, TNFRSF8, GZMB, TIA1
3lactate448.3GZMB, NPM1, NCAM1, BCL6, ALK
4paraffin447.6TIA1, GZMB, TNFRSF8, NPM1, NCAM1, BCL6
5tyrosine447.2GZMB, TNFRSF8, NPM1, NCAM1, LTK, BCL6

GO Terms for genes affiliated with Reticulosarcoma

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16Gene Ontology
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Biological processes related to Reticulosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytolysisGO:01983510.0LYZ, GZMB

Products for genes affiliated with Reticulosarcoma

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Sources for Reticulosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet