MCID: RTN014
MIFTS: 47

Retinal Artery Occlusion malady

Eye diseases category

Aliases & Classifications for Retinal Artery Occlusion

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
See all sources

Retinal Artery Occlusion, Aliases & Descriptions:

Name: Retinal Artery Occlusion 9 43 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:8483
MeSH33 D015356
SNOMED-CT55 232035005
NCIt38 C34978

Summaries for Retinal Artery Occlusion

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MalaCards based summary: Retinal Artery Occlusion is related to central retinal artery occlusion and branch retinal artery occlusion. An important gene associated with Retinal Artery Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Dissolution of Fibrin Clot and Selected targets of HNF1. The compounds spectrozyme and ancrod have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are embryogenesis and renal/urinary system.

Related Diseases for Retinal Artery Occlusion

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Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 260)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal artery occlusion32.9SLC17A8, PLAT
2branch retinal artery occlusion32.6F5, PSD
3patent foramen ovale31.5F5
4retinal vein occlusion31.5F5, MTHFR, SERPINC1, APOH
5systemic lupus erythematosus31.4CRP
6lupus erythematosus31.3F5, SERPINC1, APOH, F2
7sneddon syndrome31.2SERPINC1, APOH
8retinal vasculitis31.2APOH
9nonarteritic anterior ischemic optic neuropathy31.2F5, MTHFR
10central retinal vein occlusion31.1F5, PLAT, MTHFR, APOH
11purpura31.1SERPINC1
12homocystinuria31.1F5, MTHFR, SERPINC1
13endophthalmitis31.0PLAT
14retinal vascular occlusion30.9F5, APOH
15vasculitis30.9CRP, APOH, TNF, F2
16crohn's disease30.6CRP, TNF
17meningitis30.5CRP, IL6
18hepatitis c30.5IL10, TNF, F2
19antiphospholipid syndrome30.5F5, PLAT, F8, MTHFR, SERPINC1, APOH
20protein s deficiency30.4F5, F8, MTHFR, SERPINC1, SERPINE1, APOH
21atrial fibrillation30.3PLAT, ACE, F2
22uveitis30.0IL10, ACE, TNF
23pneumonia29.7HMOX1, CRP, IL6, IL10, TNF
24hyperhomocysteinemia29.7F5, CRP, PLAT, F8, MTHFR, SERPINC1
25deficiency anemia29.6CRP, IL6, ACE, F9, F2
26thrombophilia29.5F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
27myocardial infarction28.8F5, CRP, PLAT, F8, ITGB3, ACE
28atherosclerosis28.2HMOX1, CRP, PLAT, IL6, IL10, ITGB3
29retinitis11.5
30neuropathy10.8
31ischemic optic neuropathy10.6
32cerebritis10.6
33susac syndrome10.6
34blindness10.6
35churg-strauss syndrome10.6
36sickle cell disease10.6
37factor xiii deficiency10.6F5
38hepatorenal syndrome10.6F2
39arteriovenous fistula10.5HMOX1
40homocysteinemia10.5F5, MTHFR
41eclampsia10.5MTHFR, SERPINC1
42riboflavin deficiency10.5MTHFR
43meningococcemia10.5F5, SERPINC1
44post-thrombotic syndrome10.5F5, SERPINC1
45neovascular glaucoma10.5
46transient retinal arterial occlusion10.5
47choroiditis10.5
48aneurysm10.5
49carotid artery thrombosis10.5SERPINE1
50legg-calve-perthes disease10.5F5, SERPINC1

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to retinal artery occlusion

Symptoms for Retinal Artery Occlusion

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Drugs & Therapeutics for Retinal Artery Occlusion

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Drug clinical trials:

Search ClinicalTrials for Retinal Artery Occlusion

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

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Anatomical Context for Retinal Artery Occlusion

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MalaCards organs/tissues related to Retinal Artery Occlusion:

31
Eye, Retina, Brain, Thyroid, Breast, T cells

Animal Models for Retinal Artery Occlusion or affiliated genes

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MGI Mouse Phenotypes related to Retinal Artery Occlusion:

35 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5F2, F9, TNF, SERPINC1, ITGB3, IL10
2MP:00053678.4SERPINE1, SERPINC1, ACE, ITGB3, IL6, HMOX1
3MP:00053918.3TNF, SERPINC1, MTHFR, ITGB3, IL10, IL6
4MP:00020068.2TNF, SERPINE1, ACE, ITGB3, IL10, IL6
5MP:00053908.2F2, TNF, MTHFR, ITGB3, IL10, IL6
6MP:00053818.2F2, TNF, ITGB3, IL10, IL6, PLAT
7MP:00053698.0TNF, ITGB3, IL10, IL6, PLAT, HMOX1
8MP:00107717.9F2, TNF, SERPINE1, MTHFR, ITGB3, IL10
9MP:00053867.6TNF, ACE, IL10, IL6, PLAT, F5
10MP:00053897.6F2, TNF, SERPINC1, MTHFR, ACE, ITGB3
11MP:00053847.5TNF, ACE, ITGB3, IL10, IL6, PLAT
12MP:00053887.5F2, THY1, TNF, SERPINE1, ITGB3, IL10
13MP:00036317.4SERPINC1, TNF, THY1, F2, MTHFR, IL10
14MP:00053707.3F9, TNF, SERPINE1, SERPINC1, ACE, ITGB3
15MP:00053787.0F2, TNF, SERPINE1, MTHFR, ACE, ITGB3
16MP:00053976.6SERPINC1, SERPINE1, TNF, F9, F2, ACE
17MP:00053856.4F2, F9, TNF, SERPINE1, SERPINC1, ACE
18MP:00053876.2SERPINC1, SERPINE1, TNF, F9, F2, ACE
19MP:00107686.0SERPINC1, SERPINE1, APOH, TNF, F9, F2
20MP:00053765.6HMOX1, F2, F9, TNF, APOH, SERPINE1

Publications for Retinal Artery Occlusion

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Articles related to Retinal Artery Occlusion:

(show top 50)    (show all 626)
idTitleAuthorsYear
1
Retinal and choroidal changes and visual outcome in central retinal artery occlusion: an optical coherence tomography study. (25579642)
2015
2
Interest of local intra-arterial fibrinolysis in acute central retinal artery occlusion: Clinical experience in 16 patients. (25451669)
2014
3
Peripheral retinal ischemia after intravenous tissue plasminogen activator for central retinal artery occlusion. (25284117)
2014
4
Central retinal artery occlusion and brain infarctions after nasal filler injection. (25434051)
2014
5
Seronegative granulomatous polyangiitis with central retinal artery occlusion as the initial manifestation. (25372516)
2014
6
Systemic prostaglandin E1 to treat acute central retinal artery occlusion. (23580487)
2013
7
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
8
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
9
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
10
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
11
Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections. (22835509)
2012
12
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
13
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
14
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
15
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
16
Branch retinal artery occlusion after septoplasty. (22785539)
2010
17
Branch retinal artery occlusion after septoplasty. (21117572)
2010
18
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
19
Two cases of branch retinal arterial occlusion after carotid artery stenting in the carotid stenosis. (19337482)
2009
20
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
21
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
22
Restoration of retinal blood flow via translumenal Nd:YAG embolysis/embolectomy (TYL/E) for central and branch retinal artery occlusion. (18301027)
2008
23
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
24
Recovery of retinal sensitivity after transient branch retinal artery occlusion. (17674925)
2007
25
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
26
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
27
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
28
Improved interpretation of flow maps obtained by scanning laser Doppler flowmetry using a rat model of retinal artery occlusion. (15623770)
2005
29
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
30
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
31
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
32
Translumenal Nd:YAG laser embolysis for branch retinal artery occlusion. (11927856)
2002
33
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
34
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
35
Bilateral prepapillary loops with unilateral branch retinal artery occlusion following thrombus at the loop apex. (11217933)
2001
36
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
37
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
38
Collaterals in branch retinal artery occlusion. (10219042)
1999
39
Branch retinal artery occlusion: angiographic demonstration of increased retinal blood flow after external carotid endarterectomy. (10088062)
1999
40
Internal carotid artery dissection causing a branch retinal artery occlusion in a young adult. (9625559)
1998
41
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
42
Central retinal artery occlusion after varicella. (1642311)
1992
43
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
44
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
45
A case of sudden retinal artery occlusion and blindness in pregnancy. (3808517)
1987
46
Branch retinal artery occlusion in patients with Hodgkin's disease. (6703578)
1984
47
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
48
Central retinal artery occlusion. (1121994)
1975
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Retinal Artery Occlusion

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Expression for genes affiliated with Retinal Artery Occlusion

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Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for genes affiliated with Retinal Artery Occlusion

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Pathways related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SERPINE1, PLAT
29.4THY1, SERPINE1, ITGB3
3
Show member pathways
9.4SERPINE1, ITGB3, F8, F5
49.3HMOX1, IL6, SERPINE1
59.3IL6, ITGB3, TNF
69.3SERPINE1, IL6, PLAT
79.2IL6, SERPINE1, TNF
89.2IL10, ITGB3, THY1
9
Show member pathways
9.1F5, F8, SERPINC1, F9, F2
10
Show member pathways
IL27-mediated signaling events36
9.1TNF, IL10, IL6
119.1TNF, IL10, IL6
129.1IL6, IL10, TNF
139.1TNF, IL10, IL6
149.1IL6, IL10, TNF
159.1TNF, IL10, IL6
169.1TNF, IL10, IL6
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.0HMOX1, IL6, SERPINE1, TNF
188.8TNF, IL10, IL6, HMOX1
19
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway58
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB58
Development Angiopoietin Tie2 signaling58
8.8IL6, IL10, TNF, F2
20
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
8.8IL6, ITGB3, ACE, TNF
218.7THY1, TNF, IL6, PLAT
22
Show member pathways
8.6IL6, IL10, ITGB3, TNF, F2
23
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.5F2, F9, SERPINE1, SERPINC1, F8, PLAT
24
Show member pathways
8.5F5, F2, F9, SERPINE1, SERPINC1, F8
25
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.3IL6, IL10, ACE, SERPINE1, TNF
26
Show member pathways
8.3F2, F9, SERPINE1, SERPINC1, ITGB3, F8
27
Show member pathways
thioredoxin pathway36
8.1F2, TNF, SERPINE1, MTHFR, IL6, PLAT

Compounds for genes affiliated with Retinal Artery Occlusion

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Compounds related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idCompoundScoreTop Affiliating Genes
1spectrozyme439.8F5, SERPINC1, F2, PLAT
2ancrod439.6PLAT, F5, SERPINC1, SERPINE1, F2
3batroxobin439.6F5, PLAT, SERPINE1, F2
4fondaparinux439.5F2, PLAT, F9, SERPINC1, F5
5p-amino benzamidine439.5PLAT, SERPINC1, SERPINE1, F9
6kaolin439.5F9, APOH, F8, F5, F2
7epsilon aminocaproic acid439.4F9, F2, SERPINE1, SERPINC1, PLAT
8tirofiban43 1210.4CRP, ITGB3, SERPINC1, PLAT, F2
9abciximab43 1210.3SERPINC1, ITGB3, PLAT, CRP, F2
10bivalirudin43 1210.2F2, SERPINC1, PLAT, F5
11phosphatidylethanolamine43 1210.1APOH, F8, F9, F5, F2
12tranexamic acid43 1210.1SERPINE1, SERPINC1, F9, F2, F8, PLAT
13polyethylene glycol439.0F8, HMOX1, F5, CRP, SERPINC1, F2
14ristocetin439.0F2, F5, PLAT, F8, ITGB3, SERPINC1
15desmopressin43 59 28 1212.0F5, PLAT, F8, SERPINC1, SERPINE1, F9
16protamine438.9IL6, F5, F2, SERPINE1, PLAT, SERPINC1
17hirudin438.9F2, F9, SERPINE1, SERPINC1, F8, PLAT
18cdp571438.9TNF, IL10, IL6, CRP
19clopidogrel43 49 24 1211.9PLAT, ACE, ITGB3, F2, CRP, SERPINC1
20pge1438.8APOH, F2, IL6, PLAT, F5, SERPINE1
21citrate438.8CRP, HMOX1, F2, F8, SERPINC1, F9
22kininogen438.6F9, PLAT, F5, ACE, APOH, SERPINE1
23gabexate mesilate438.4F5, CRP, PLAT, IL6, IL10, SERPINC1
24heparin43 28 24 1211.4PLAT, SERPINC1, F2, APOH, F8, SERPINE1
25cyclophosphamide43 49 1210.3APOH, IL10, F8, CRP, F5, MTHFR
26etanercept43 49 1210.3IL6, IL10, APOH, CRP, TNF
278-isoprostane438.3HMOX1, SERPINE1, APOH, IL10, IL6, CRP
28warfarin43 49 24 1211.3SERPINC1, APOH, F9, F2, MTHFR, F8
29aprotinin43 129.2F5, PLAT, IL6, IL10, SERPINC1, SERPINE1
30ivig438.1CRP, IL6, IL10, APOH, TNF, F9
31rituximab43 49 1210.1IL10, APOH, TNF, IL6, F8, CRP
32homocysteine43 249.1F5, CRP, PLAT, F8, MTHFR, SERPINC1
33prednisolone43 28 1210.1F9, TNF, IL10, F8, CRP, APOH
34methotrexate49 43 1210.0F2, TNF, APOH, MTHFR, IL6, IL10
35lactate437.9HMOX1, F5, CRP, F8, IL6, APOH
36simvastatin43 49 59 28 24 1212.8SERPINE1, TNF, F2, IL10, IL6, CRP
37aspartate437.8F9, F5, PLAT, CRP, F8, IL10
38cyclosporin a43 28 599.7F2, F9, TNF, MTHFR, IL10, HMOX1
39endotoxin437.7F9, TNF, APOH, SERPINE1, IL10, IL6
40alanine437.6F5, CRP, F8, IL6, ITGB3, MTHFR
41estrogen437.6F2, F9, HMOX1, F5, F8, IL6
42atorvastatin43 49 28 24 1211.6HMOX1, SERPINE1, TNF, ACE, IL10, F5
43aspirin43 49 28 2410.4PLAT, F8, ITGB3, ACE, MTHFR, SERPINC1
44prostacyclin437.4HMOX1, F5, CRP, PLAT, F8, IL10
45cholesterol43 28 24 1210.3APOH, MTHFR, ACE, IL6, PLAT, F8
46vegf437.3F5, APOH, CRP, SERPINE1, HMOX1, SERPINC1
47nitric oxide43 24 129.2ACE, IL10, IL6, F8, F5, HMOX1
48creatinine437.0F2, F9, APOH, SERPINE1, SERPINC1, MTHFR
49fibrinogen436.9SERPINC1, MTHFR, ITGB3, IL6, F8, PLAT
50lipid436.6CRP, F8, IL6, SERPINE1, APOH, TNF

GO Terms for genes affiliated with Retinal Artery Occlusion

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Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.6F5, F8, SERPINE1
2external side of plasma membraneGO:00098978.2THY1, TNF, ACE, IL6
3extracellular regionGO:00055766.6F2, F9, TNF, SERPINE1, SERPINC1, ACE
4plasma membraneGO:00058866.3TNF, F9, THY1, F2, SERPINE1, SERPINC1
5extracellular spaceGO:00056156.1HMOX1, F2, TNF, APOH, SERPINE1, SERPINC1

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:003163910.2APOH, PLAT
2smooth muscle cell migrationGO:001490910.2PLAT, ITGB3
3positive regulation of chemokine biosynthetic processGO:004508010.2HMOX1, TNF
4negative regulation of blood coagulationGO:003019510.1APOH, SERPINE1
5negative regulation of fibrinolysisGO:005191810.1SERPINE1, APOH, F2
6peptidyl-glutamic acid carboxylationGO:001718710.1F2, F9
7positive regulation of blood coagulationGO:003019410.1F2, APOH, SERPINE1
8receptor biosynthetic processGO:003280010.0IL10, TNF
9negative regulation of cytokine secretion involved in immune responseGO:000274010.0IL10, TNF
10fibrinolysisGO:004273010.0PLAT, SERPINE1, F2
11negative regulation of macrophage derived foam cell differentiationGO:00107459.9ITGB3, CRP
12epithelial cell proliferation involved in salivary gland morphogenesisGO:00606649.8IL6, TNF
13positive regulation of protein phosphorylationGO:00019349.8ITGB3, TNF, F2
14negative regulation of proteolysisGO:00458619.8F2, PLAT
15platelet degranulationGO:00025769.7SERPINE1, ITGB3, F8, F5
16negative regulation of growth of symbiont in hostGO:00441309.7IL10, TNF
17negative regulation of interleukin-6 productionGO:00327159.7IL10, TNF
18negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:019020429.7HMOX1, SERPINE1
19blood coagulation, intrinsic pathwayGO:00075979.6F2, F9, APOH, F8
20positive regulation of smooth muscle cell proliferationGO:00486619.6TNF, IL6, HMOX1
21positive regulation of chemokine productionGO:00327229.6IL6, TNF
22response to hypoxiaGO:00016669.6TNF, MTHFR, PLAT, CRP
23defense response to Gram-positive bacteriumGO:00508309.5TNF, IL6, CRP
24positive regulation of sequence-specific DNA binding transcription factor activityGO:00510919.3IL6, IL10, TNF
25negative regulation of lipid storageGO:00108889.3CRP, IL6, ITGB3, TNF
26acute-phase responseGO:00069539.2F2, IL6, F8, CRP
27response to glucocorticoidGO:00513849.1PLAT, IL6, IL10, TNF
28response to drugGO:00424939.1TNF, MTHFR, IL10, IL6
29inflammatory responseGO:00069548.9TNF, IL10, IL6, CRP
30platelet activationGO:00301688.9F2, SERPINE1, ITGB3, IL6, F8, F5
31blood coagulationGO:00075968.6F2, F9, SERPINE1, SERPINC1, ITGB3, F8

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.7SERPINC1, SERPINE1, TNF
2serine-type endopeptidase activityGO:00042528.7F2, F9, F8, PLAT, F5
3protein bindingGO:00055155.0F5, F2, THY1, TNF, APOH, SERPINE1

Products for genes affiliated with Retinal Artery Occlusion

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Sources for Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet