MCID: RTN014
MIFTS: 42

Retinal Artery Occlusion

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Artery Occlusion

MalaCards integrated aliases for Retinal Artery Occlusion:

Name: Retinal Artery Occlusion 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8483
MeSH 42 D015356
NCIt 47 C34978
SNOMED-CT 64 232035005
UMLS 69 C0035302

Summaries for Retinal Artery Occlusion

MalaCards based summary : Retinal Artery Occlusion is related to central retinal artery occlusion and essential thrombocythemia, and has symptoms including amaurosis fugax An important gene associated with Retinal Artery Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 285)
id Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 33.6 APOH F2 MTHFR SERPINC1
2 essential thrombocythemia 29.5 F2 F8 SERPINC1
3 loiasis 29.4 IL10 SERPINE1
4 myocardial infarction 27.2 F2 F5 F8 IL10 MTHFR SERPINC1
5 branch retinal artery occlusion 12.4
6 transient retinal arterial occlusion 12.3
7 retinitis 11.1
8 partial arterial retinal occlusion 11.0
9 multicentric osteolysis nephropathy 10.7 F5 MTHFR
10 variably protease-sensitive prionopathy 10.6 F2 F5
11 mcgillivray syndrome 10.6 APOH F5
12 porphyria 10.6 F2 MTHFR
13 accessory deep peroneal nerve 10.6 APOH F5
14 bile duct cystadenoma 10.6 F2 F5
15 landau-kleffner syndrome 10.5 APOH F2
16 prostatitis 10.5 APOH F2
17 irak4 deficiency 10.5 F2 F5
18 pyridoxine deficiency anemia 10.5 F2 SERPINC1
19 acquired von willebrand syndrome 10.5 F5 F8
20 schizencephaly 10.5 F5 MTHFR
21 myiasis 10.5 F2 SERPINC1
22 acquired pure red cell aplasia 10.5 F5 F8
23 egg allergy 10.5 F2 SERPINC1
24 rectum neuroendocrine neoplasm 10.5 F2 SERPINC1
25 factor v and factor viii, combined deficiency of 10.5 F5 F8
26 syndactyly, mesoaxial synostotic, with phalangeal reduction 10.5 F2 SERPINC1
27 littre gland carcinoma 10.5 F2 SERPINC1
28 acute lymphocytic leukemia 10.4 F2 F5
29 pilomyxoid astrocytoma 10.4 F2 SERPINC1
30 angelucci's syndrome 10.4 F2 SERPINC1
31 lethal congenital contracture syndrome 10.4 F2 SERPINC1
32 von willibrand disease, type 3 10.4 F2 F8
33 lujo hemorrhagic fever 10.4 F2 SERPINC1
34 bronchopulmonary dysplasia 10.4 APOH F8
35 childhood brain stem glioma 10.4 F2 SERPINC1
36 female breast cancer 10.4 F2 F8
37 social phobia 10.4 F2 F8
38 autonomic neuropathy 10.4 F2 F8
39 neuromyelitis optica 10.4 MTHFR SERPINE1
40 primary pigmented nodular adrenocortical disease 10.3 F2 F5 MTHFR
41 homologous wasting disease 10.3 F2 F5 MTHFR
42 hepatocellular adenoma 10.3 F2 F5 MTHFR
43 aids wasting syndrome 10.3 APOH IL10
44 thrombomodulin anomalies, familial 10.3 F2 F5 MTHFR
45 rete ovarii adenoma 10.3 F2 F8
46 hemophagocytic lymphohistiocytosis 10.3 IL10 MTHFR
47 hyperphenylalaninemia 10.3 F2 F8
48 pregnancy loss, recurrent 1 10.3 APOH F5 MTHFR
49 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 10.3 F5 SERPINE1
50 charcot-marie-tooth disease 10.3 F2 F5 MTHFR

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to Retinal Artery Occlusion

Symptoms & Phenotypes for Retinal Artery Occlusion

UMLS symptoms related to Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Artery Occlusion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 APOH F2 F5 F8 HMOX1 IL10
2 cardiovascular system MP:0005385 9.8 F2 F5 HMOX1 IL10 SERPINC1 SERPINE1
3 mortality/aging MP:0010768 9.61 F2 F5 F8 HMOX1 IL10 MTHFR
4 liver/biliary system MP:0005370 9.55 F5 HMOX1 IL10 SERPINC1 SERPINE1
5 reproductive system MP:0005389 9.1 F2 F8 HMOX1 IL10 MTHFR SERPINC1

Drugs & Therapeutics for Retinal Artery Occlusion

Drugs for Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 39)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4
3 Angiogenesis Modulating Agents Phase 4
4 insulin Phase 4
5 Insulin, Globin Zinc Phase 4
6
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
7
Salicylic acid Approved, Vet_approved Phase 3 69-72-7 338
8
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
9
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
10 Fibrinolytic Agents Phase 3,Phase 1
11 Plasminogen Phase 3,Phase 1
12 Tissue Plasminogen Activator Phase 3,Phase 1
13 Neurotransmitter Agents Phase 3,Phase 2
14 Analgesics Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Anti-Inflammatory Agents Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Antipyretics Phase 3
19 Antirheumatic Agents Phase 3
20 Cyclooxygenase Inhibitors Phase 3
21 Peripheral Nervous System Agents Phase 3
22 Pharmaceutical Solutions Phase 3
23 Platelet Aggregation Inhibitors Phase 3
24 Adrenergic Agents Phase 3
25 Adrenergic Antagonists Phase 3
26 Adrenergic beta-Antagonists Phase 3
27 Anticoagulants Phase 3
28 Anticonvulsants Phase 3
29 calcium heparin Phase 3
30 Carbonic Anhydrase Inhibitors Phase 3
31 diuretics Phase 3
32 Natriuretic Agents Phase 3
33
Adenosine Approved, Investigational Phase 2 58-61-7 60961
34
Regadenoson Approved Phase 2 313348-27-5 219024
35
Reteplase Approved Phase 1 133652-38-7 65820
36
Tenecteplase Approved Phase 1 191588-94-0
37
Bevacizumab Approved, Investigational 216974-75-3
38 Ophthalmic Solutions
39 Tetrahydrozoline

Interventional clinical trials:

(show all 25)

id Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Not yet recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
6 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
7 Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion Unknown status NCT01581411 Phase 1 Tissue Plasminogen Activator
8 Intravitreal Aflibercept Injection for Symptomatic Macular Edema From Retinal Artery Macroaneurysms Recruiting NCT02403128 Phase 1 aflibercept
9 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
10 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
11 OCT in Rare Chorioretinal Diseases Unknown status NCT02141308
12 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Optive
13 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
14 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Recruiting NCT02679716
15 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
16 Spectral-domain Optical Coherence Tomography of the Eye Recruiting NCT02614625
17 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
18 Investigation of Biomarkers in Susac Syndrome Recruiting NCT01273792
19 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Recruiting NCT02811536
20 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
21 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
22 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Not yet recruiting NCT03313817
23 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Not yet recruiting NCT02898480
24 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Not yet recruiting NCT03061526
25 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

Anatomical Context for Retinal Artery Occlusion

MalaCards organs/tissues related to Retinal Artery Occlusion:

39
Eye, Retina, Brain, Thyroid, T Cells, Lung

Publications for Retinal Artery Occlusion

Articles related to Retinal Artery Occlusion:

(show top 50) (show all 750)
id Title Authors Year
1
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
2
Systemic intravenous abciximab: a novel treatment for acute central retinal artery occlusion? ( 28470954 )
2017
3
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
4
Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis. ( 28433123 )
2017
5
Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study. ( 28228436 )
2017
6
Acute-on-Chronic: Retinal Artery Occlusion Following Retinal Vein Occlusion. ( 28734330 )
2017
7
Iatrogenic central retinal artery occlusion after carotid body tumor embolization and excision. ( 28401029 )
2017
8
Disappearance of Myelinated Retinal Nerve Fibers after Central Retinal Artery Occlusion Reveals Nettleship Collaterals. ( 28823346 )
2017
9
Fundus autofluorescence in retinal artery occlusion: A more precise diagnosis. ( 28882392 )
2017
10
Combined branch retinal vein and branch retinal artery occlusion - clinical features, systemic associations, and outcomes. ( 28440254 )
2017
11
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017
12
Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid. ( 28705840 )
2017
13
Retinal artery occlusion and associated recurrent vascular risk with underlying etiologies. ( 28570629 )
2017
14
Expression of angiogenic mediators in a patient with a retinal artery occlusion. ( 28774531 )
2017
15
Treatment of retinal artery occlusion using transluminal Nd:YAG laser: a systematic review and meta-analysis. ( 28823062 )
2017
16
Rescue vitrectomy with blocked artery massage and bloodletting for branch retinal artery occlusion. ( 28513500 )
2017
17
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
18
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
19
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
20
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
21
Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998-2013. ( 28665867 )
2017
22
Retinal Artery Occlusion Secondary to Buerger's Disease (Thromboangiitis Obliterans). ( 28491481 )
2017
23
Hyperbaric, Central Retinal Artery Occlusion ( 28613728 )
2017
24
Is Intravenous Thrombolysis Safe and Effective in Central Retinal Artery Occlusion? A Critically Appraised Topic. ( 28644261 )
2017
25
A Framework for Classification and Segmentation of Branch Retinal Artery Occlusion in SD-OCT. ( 28459688 )
2017
26
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
27
Visual loss due to optic nerve infarction and central retinal artery occlusion after spine surgery in the prone position: A case report. ( 28767569 )
2017
28
Central retinal artery occlusion after percutaneous nephrolithotomy lithotripsy in the prone position. ( 28097535 )
2017
29
The efficacy of hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 28500127 )
2017
30
Carotid cavernous fistula with central retinal artery occlusion and Terson syndrome after mid-facial trauma. ( 28580223 )
2017
31
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017
32
PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH RETINAL ARTERY OCCLUSION AFTER COSMETIC FILLER INJECTION. ( 27763945 )
2017
33
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
34
Central Retinal Artery Occlusion by Left Atrial Myxoma. ( 28243029 )
2017
35
CENTRAL RETINAL ARTERY OCCLUSION IN A YOUNG HIV-INFECTED PATIENT ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY. ( 27111556 )
2016
36
Intra-arterial Thrombolysis for Central Retinal Artery Occlusion after the Coil Embolization of Paraclinoid Aneurysm. ( 28184347 )
2016
37
Multimodal imaging of central retinal artery occlusion with retained cilioretinal perfusion. ( 27530879 )
2016
38
Combined central retinal vein and branch retinal artery occlusion in hyperhomocysteinaemia. ( 27974343 )
2016
39
Retinal artery occlusion by left atrial myxoma misdiagnosed as thrombus. ( 27064439 )
2016
40
Retinal Artery Occlusion and the Risk of Stroke Development: Twelve-Year Nationwide Cohort Study. ( 26742801 )
2016
41
Central Retinal Artery Occlusion: A Literature Review and the Rationale for Hyperbaric Oxygen Therapy. ( 27039492 )
2016
42
STRANGULATION-INDUCED CENTRAL RETINAL ARTERY OCCLUSION: CASE REPORT AND REVIEW OF THE LITERATURE. ( 27337704 )
2016
43
Central retinal artery occlusion, an early sign of crizotinib resistance in an alk positive adenocarcinoma of lung: A rare case report. ( 27606884 )
2016
44
The Characteristics of Retinal Emboli and its Association With Vascular Reperfusion in Retinal Artery Occlusion. ( 27598864 )
2016
45
Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion. ( 27745901 )
2016
46
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
47
Central Retinal Artery Occlusion after the Endovascular Treatment of Unruptured Ophthalmic Artery Aneurysm: A Case Report and a Literature Review. ( 28664002 )
2016
48
Retinal artery occlusion due to Bartonella henselae infection: a case series. ( 26748767 )
2016
49
Branch retinal artery occlusion in a patient with one eye. Laser Nd:YAG approach. ( 26896065 )
2016
50
Necrotizing Fasciitis of the Periorbital Region Complicated by Combined Central Retinal Artery Occlusion, Central Retinal Vein Occlusion, and Posterior Ciliary Occlusion. ( 27556345 )
2016

Variations for Retinal Artery Occlusion

Expression for Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for Retinal Artery Occlusion

GO Terms for Retinal Artery Occlusion

Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 APOH F2 F5 F8 IL10 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.46 F2 F5 F8 SERPINC1
3 ER to Golgi transport vesicle GO:0030134 9.32 F5 F8
4 extracellular space GO:0005615 9.23 APOH F2 F5 F8 HMOX1 IL10
5 platelet alpha granule lumen GO:0031093 9.13 F5 F8 SERPINE1

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 F2 F5 F8 SERPINC1
2 cellular protein metabolic process GO:0044267 9.7 F2 F5 SERPINC1
3 ER to Golgi vesicle-mediated transport GO:0006888 9.67 F2 F5 F8
4 platelet degranulation GO:0002576 9.67 APOH F5 F8 SERPINE1
5 blood circulation GO:0008015 9.57 F5 MTHFR
6 acute-phase response GO:0006953 9.56 F2 F8
7 liver regeneration GO:0097421 9.55 HMOX1 IL10
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.54 HMOX1 SERPINE1
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.51 IL10 SERPINE1
10 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
11 fibrinolysis GO:0042730 9.48 F2 SERPINE1
12 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.46 HMOX1 IL10
13 negative regulation of blood coagulation GO:0030195 9.43 APOH SERPINE1
14 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F2 F8
15 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
16 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
17 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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