MCID: RTN014
MIFTS: 58

Retinal Artery Occlusion malady

Cardiovascular diseases, Eye diseases categories
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Summaries for Retinal Artery Occlusion

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Wikipedia:65 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards based summary: Retinal Artery Occlusion is related to central retinal artery occlusion and branch retinal artery occlusion. An important gene associated with Retinal Artery Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Dissolution of Fibrin Clot and Selected targets of HNF1. The compounds spectrozyme and ancrod have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are embryogenesis and renal/urinary system.

Aliases & Classifications for Retinal Artery Occlusion

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH
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Retinal Artery Occlusion, Aliases & Descriptions:

Name: Retinal Artery Occlusion 8 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Eye diseases


External Ids:

Disease Ontology8 DOID:8483
NCIt39 C34978
SNOMED-CT57 232035005
MeSH34 D015356

Related Diseases for Retinal Artery Occlusion

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Diseases in the Central Retinal Artery Occlusion family:

retinal artery occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal artery occlusion32.9SLC17A8, PLAT
2branch retinal artery occlusion32.6F5, PSD
3retinal vein occlusion31.5F5, MTHFR, SERPINC1, APOH
4patent foramen ovale31.4F5
5systemic lupus erythematosus31.3CRP
6sneddon syndrome31.2SERPINC1, APOH
7lupus erythematosus31.2F5, SERPINC1, APOH, F2
8retinal vasculitis31.2APOH
9central retinal vein occlusion31.1F5, PLAT, MTHFR, APOH
10retinal vascular occlusion31.1F5, APOH
11purpura31.1SERPINC1
12homocystinuria31.1F5, MTHFR, SERPINC1
13endophthalmitis31.0PLAT
14vasculitis30.8CRP, APOH, TNF, F2
15crohn's disease30.6CRP, TNF
16hepatitis c30.5IL10, TNF, F2
17antiphospholipid syndrome30.4F5, PLAT, F8, MTHFR, SERPINC1, APOH
18protein s deficiency30.4F5, F8, MTHFR, SERPINC1, SERPINE1, APOH
19diabetic retinopathy30.3ITGB3, ACE, SERPINE1
20uveitis30.0IL10, ACE, TNF
21pneumonia29.8HMOX1, CRP, IL6, IL10, TNF
22hyperhomocysteinemia29.7F5, CRP, PLAT, F8, MTHFR, SERPINC1
23deficiency anemia29.6CRP, IL6, ACE, F9, F2
24thromboembolism29.5F5, PLAT, F8, MTHFR, SERPINC1, SERPINE1
25myocardial infarction28.8F5, CRP, PLAT, F8, ITGB3, ACE
26atherosclerosis28.2HMOX1, CRP, PLAT, IL6, IL10, ITGB3
27retinitis11.5
28neuropathy10.8
29ischemic optic neuropathy10.6
30anterior ischemic optic neuropathy10.6
31churg-strauss syndrome10.6
32cerebritis10.6
33susac syndrome10.6
34blindness10.6
35factor xii deficiency10.6F5
36sickle cell disease10.6
37hepatorenal syndrome10.6F2
38wegener's granulomatosis10.5
39arteriovenous fistula10.5HMOX1
40homocysteinemia10.5F5, MTHFR
41eclampsia10.5MTHFR, SERPINC1
42riboflavin deficiency10.5MTHFR
43meningococcemia10.5F5, SERPINC1
44post-thrombotic syndrome10.5F5, SERPINC1
45carotid artery thrombosis10.5SERPINE1
46legg-calve-perthes disease10.5F5, SERPINC1
47neovascular glaucoma10.5
48aneurysm10.5
49cardiac tamponade10.5F8
50sagittal sinus thrombosis10.5F5, SERPINC1

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to retinal artery occlusion

Symptoms for Retinal Artery Occlusion

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Drugs & Therapeutics for Retinal Artery Occlusion

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Drug clinical trials:

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Genetic Tests for Retinal Artery Occlusion

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Anatomical Context for Retinal Artery Occlusion

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MalaCards organs/tissues related to Retinal Artery Occlusion:

32
Eye, Retina, Brain, Thyroid, Breast, T cells

Animal Models for Retinal Artery Occlusion or affiliated genes

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MGI Mouse Phenotypes related to Retinal Artery Occlusion:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053808.5F2, F9, TNF, SERPINC1, ITGB3, IL10
2MP:00053678.4SERPINE1, SERPINC1, ACE, ITGB3, IL6, HMOX1
3MP:00053918.3TNF, SERPINC1, MTHFR, ITGB3, IL10, IL6
4MP:00020068.2TNF, SERPINE1, ACE, ITGB3, IL10, IL6
5MP:00053908.2F2, TNF, MTHFR, ITGB3, IL10, IL6
6MP:00053818.2F2, TNF, ITGB3, IL10, IL6, PLAT
7MP:00053698.0TNF, ITGB3, IL10, IL6, PLAT, HMOX1
8MP:00107717.9F2, TNF, SERPINE1, MTHFR, ITGB3, IL10
9MP:00053867.6TNF, ACE, IL10, IL6, PLAT, F5
10MP:00053897.6F2, TNF, SERPINC1, MTHFR, ACE, ITGB3
11MP:00053847.5TNF, ACE, ITGB3, IL10, IL6, PLAT
12MP:00053887.5F2, THY1, TNF, SERPINE1, ITGB3, IL10
13MP:00036317.4SERPINC1, TNF, THY1, F2, MTHFR, IL10
14MP:00053707.3F9, TNF, SERPINE1, SERPINC1, ACE, ITGB3
15MP:00053787.0F2, TNF, SERPINE1, MTHFR, ACE, ITGB3
16MP:00053976.6SERPINC1, SERPINE1, TNF, F9, F2, ACE
17MP:00053856.4F2, F9, TNF, SERPINE1, SERPINC1, ACE
18MP:00053876.2SERPINC1, SERPINE1, TNF, F9, F2, ACE
19MP:00107686.0SERPINC1, SERPINE1, APOH, TNF, F9, F2
20MP:00053765.6HMOX1, F2, F9, TNF, APOH, SERPINE1

Publications for Retinal Artery Occlusion

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Articles related to Retinal Artery Occlusion:

(show top 50)    (show all 603)
idTitleAuthorsYear
1
Peripheral retinal ischemia after intravenous tissue plasminogen activator for central retinal artery occlusion. (25284117)
2014
2
Seronegative granulomatous polyangiitis with central retinal artery occlusion as the initial manifestation. (25372516)
2014
3
Systemic prostaglandin E1 to treat acute central retinal artery occlusion. (23580487)
2013
4
Unilateral central retinal artery occlusion as the sole presenting sign of Susac syndrome in a young man: case report. (24232952)
2013
5
Acute, bilateral, concurrent central retinal artery occlusion in sickle cell disease after use of tadalafil (Cialis). (24052082)
2013
6
Surgical embolectomy for central retinal artery occlusion. (23561615)
2013
7
Clinicopathological correlation of parapapillary atrophy in monkeys with experimental glaucoma and temporary central retinal artery occlusion. (23619503)
2013
8
Simultaneous vitreous hemorrhage and branch retinal artery occlusion after prepapillary arterial loop rupture. (23410854)
2013
9
Iatrogenic retinal artery occlusion caused by cosmetic facial filler injections. (22835509)
2012
10
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
11
ANCA-associated vasculitis with central retinal artery occlusion developing during treatment with methimazole. (23154728)
2012
12
Higher incidence of carotid stenosis in patients with central retinal artery occlusion. (20384592)
2011
13
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
14
Branch retinal artery occlusion after septoplasty. (22785539)
2010
15
Branch retinal artery occlusion after septoplasty. (21117572)
2010
16
Teaching NeuroImages: central retinal artery occlusion with cilioretinal artery sparing in giant cell arteritis. (20679629)
2010
17
Two cases of branch retinal arterial occlusion after carotid artery stenting in the carotid stenosis. (19337482)
2009
18
Translation of clinical studies to clinical practice: survey on the treatment of central retinal artery occlusion. (19540987)
2009
19
Molecular and histological changes following central retinal artery occlusion in a mouse model. (18639547)
2008
20
Restoration of retinal blood flow via translumenal Nd:YAG embolysis/embolectomy (TYL/E) for central and branch retinal artery occlusion. (18301027)
2008
21
Central retinal artery occlusion following transcatheter balloon aortic valvuloplasty in an adolescent with aortic valvular stenosis. (18094913)
2008
22
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
23
Recovery of retinal sensitivity after transient branch retinal artery occlusion. (17674925)
2007
24
A case of polyarteritis nodosa complicated by left central retinal artery occlusion, ischemic optic neuropathy, and retinal vasculitis. (16575492)
2007
25
An unusual cause of central retinal artery occlusion: acquired immunodeficiency syndrome. (17671949)
2007
26
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
27
Improved interpretation of flow maps obtained by scanning laser Doppler flowmetry using a rat model of retinal artery occlusion. (15623770)
2005
28
Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion. (15654031)
2005
29
Neodymium:yttrium-aluminum-garnet laser arteriotomy with embolectomy for central retinal artery occlusion. (14700675)
2004
30
Selective intraarterial fibrinolysis of acute central retinal artery occlusion. (14616215)
2003
31
Translumenal Nd:YAG laser embolysis for branch retinal artery occlusion. (11927856)
2002
32
Chlamydia pneumoniae in central retinal artery occlusion. (12485289)
2002
33
Henoch-Schonlein purpura with bilateral central retinal artery occlusion. (11864898)
2002
34
Bilateral prepapillary loops with unilateral branch retinal artery occlusion following thrombus at the loop apex. (11217933)
2001
35
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
36
Central retinal artery occlusion in a patient homozygous for factor V Leiden. (10927002)
2000
37
Collaterals in branch retinal artery occlusion. (10219042)
1999
38
Branch retinal artery occlusion: angiographic demonstration of increased retinal blood flow after external carotid endarterectomy. (10088062)
1999
39
Internal carotid artery dissection causing a branch retinal artery occlusion in a young adult. (9625559)
1998
40
A case of central retinal artery occlusion after carotid endoarterectomy. (9474333)
1997
41
Peripheral thrombolytic therapy for central retinal artery occlusion. CRAO Study Group. (7661736)
1995
42
Central retinal artery occlusion after varicella. (1642311)
1992
43
Central retinal artery occlusion in a child after general anesthesia. (1882928)
1991
44
Delayed filling of retinal and ciliary circulation after central retinal artery occlusion. (3060337)
1988
45
A case of sudden retinal artery occlusion and blindness in pregnancy. (3808517)
1987
46
Branch retinal artery occlusion in patients with Hodgkin's disease. (6703578)
1984
47
Central retinal artery occlusion (reversible in sickle trait with glaucoma. (952815)
1976
48
Central retinal artery occlusion. (1121994)
1975
49
Central retinal artery occlusion associated with cryoglobulinemia. (13410214)
1957
50
Bilateral central retinal artery occlusion; occurrence in a patient with cortisone-treated systemic lupus erythematosus, sickle cell trait, and active pulmonary tuberculosis. (13257998)
1955

Variations for Retinal Artery Occlusion

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Expression for genes affiliated with Retinal Artery Occlusion

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Expression patterns in normal tissues for genes affiliated with Retinal Artery Occlusion

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Pathways for genes affiliated with Retinal Artery Occlusion

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Pathways related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9SERPINE1, PLAT
29.5CRP, F8, APOH
39.4THY1, SERPINE1, ITGB3
4
Show member pathways
9.4SERPINE1, ITGB3, F8, F5
59.3HMOX1, IL6, SERPINE1
69.3IL6, ITGB3, TNF
79.3SERPINE1, IL6, PLAT
89.2IL6, SERPINE1, TNF
99.2IL10, ITGB3, THY1
10
Show member pathways
9.1F5, F8, SERPINC1, F9, F2
11
Show member pathways
IL27-mediated signaling events37
9.1TNF, IL10, IL6
129.1TNF, IL10, IL6
139.1IL6, IL10, TNF
149.1TNF, IL10, IL6
159.1IL6, IL10, TNF
169.1TNF, IL10, IL6
179.1TNF, IL10, IL6
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.0HMOX1, IL6, SERPINE1, TNF
198.8TNF, IL10, IL6, HMOX1
20
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8IL6, IL10, TNF, F2
21
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
8.8IL6, ITGB3, ACE, TNF
228.7THY1, TNF, IL6, PLAT
23
Show member pathways
8.6IL6, IL10, ITGB3, TNF, F2
24
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.5F2, F9, SERPINE1, SERPINC1, F8, PLAT
25
Show member pathways
8.5F5, F2, F9, SERPINE1, SERPINC1, F8
26
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.3IL6, IL10, ACE, SERPINE1, TNF
27
Show member pathways
8.3F2, F9, SERPINE1, SERPINC1, ITGB3, F8
28
Show member pathways
thioredoxin pathway37
8.1F2, TNF, SERPINE1, MTHFR, IL6, PLAT

Compounds for genes affiliated with Retinal Artery Occlusion

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Compounds related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 254)
idCompoundScoreTop Affiliating Genes
1spectrozyme449.8F5, SERPINC1, F2, PLAT
2ancrod449.6PLAT, F5, SERPINC1, SERPINE1, F2
3batroxobin449.6F5, PLAT, SERPINE1, F2
4fondaparinux449.5F2, PLAT, F9, SERPINC1, F5
5p-amino benzamidine449.5PLAT, SERPINC1, SERPINE1, F9
6kaolin449.5F9, APOH, F8, F5, F2
7epsilon aminocaproic acid449.4F9, F2, SERPINE1, SERPINC1, PLAT
8tirofiban44 1110.4CRP, ITGB3, SERPINC1, PLAT, F2
9abciximab44 1110.3SERPINC1, ITGB3, PLAT, CRP, F2
10bivalirudin44 1110.2F2, SERPINC1, PLAT, F5
11phosphatidylethanolamine44 1110.1APOH, F8, F9, F5, F2
12tranexamic acid44 1110.1SERPINE1, SERPINC1, F9, F2, F8, PLAT
13polyethylene glycol449.0F8, HMOX1, F5, CRP, SERPINC1, F2
14ristocetin449.0F2, F5, PLAT, F8, ITGB3, SERPINC1
15desmopressin44 61 28 1112.0F5, PLAT, F8, SERPINC1, SERPINE1, F9
16protamine448.9IL6, F5, F2, SERPINE1, PLAT, SERPINC1
17hirudin448.9F2, F9, SERPINE1, SERPINC1, F8, PLAT
18cdp571448.9TNF, IL10, IL6, CRP
19clopidogrel44 50 24 1111.9PLAT, ACE, ITGB3, F2, CRP, SERPINC1
20pge1448.8APOH, F2, IL6, PLAT, F5, SERPINE1
21citrate448.8CRP, HMOX1, F2, F8, SERPINC1, F9
22kininogen448.6F9, PLAT, F5, ACE, APOH, SERPINE1
23gabexate mesilate448.4F5, CRP, PLAT, IL6, IL10, SERPINC1
24heparin44 28 24 1111.4PLAT, SERPINC1, F2, APOH, F8, SERPINE1
25cyclophosphamide44 50 1110.3APOH, IL10, F8, CRP, F5, MTHFR
26etanercept44 50 1110.3IL6, IL10, APOH, CRP, TNF
278-isoprostane448.3HMOX1, SERPINE1, APOH, IL10, IL6, CRP
28warfarin44 50 24 1111.3SERPINC1, APOH, F9, F2, MTHFR, F8
29aprotinin44 119.2F5, PLAT, IL6, IL10, SERPINC1, SERPINE1
30ivig448.1CRP, IL6, IL10, APOH, TNF, F9
31rituximab44 50 1110.1IL10, APOH, TNF, IL6, F8, CRP
32homocysteine44 249.1F5, CRP, PLAT, F8, MTHFR, SERPINC1
33prednisolone44 28 1110.1F9, TNF, IL10, F8, CRP, APOH
34methotrexate50 44 1110.0F2, TNF, APOH, MTHFR, IL6, IL10
35lactate447.9HMOX1, F5, CRP, F8, IL6, APOH
36simvastatin44 50 61 28 24 1112.8SERPINE1, TNF, F2, IL10, IL6, CRP
37aspartate447.8F9, F5, PLAT, CRP, F8, IL10
38cyclosporin a44 28 619.7F2, F9, TNF, MTHFR, IL10, HMOX1
39endotoxin447.7F9, TNF, APOH, SERPINE1, IL10, IL6
40alanine447.6F5, CRP, F8, IL6, ITGB3, MTHFR
41estrogen447.6F2, F9, HMOX1, F5, F8, IL6
42atorvastatin44 50 28 24 1111.6HMOX1, SERPINE1, TNF, ACE, IL10, F5
43aspirin44 50 28 2410.4PLAT, F8, ITGB3, ACE, MTHFR, SERPINC1
44prostacyclin447.4HMOX1, F5, CRP, PLAT, F8, IL10
45cholesterol44 28 24 1110.3APOH, MTHFR, ACE, IL6, PLAT, F8
46vegf447.3F5, APOH, CRP, SERPINE1, HMOX1, SERPINC1
47nitric oxide44 24 119.2ACE, IL10, IL6, F8, F5, HMOX1
48creatinine447.0F2, F9, APOH, SERPINE1, SERPINC1, MTHFR
49fibrinogen446.9SERPINC1, MTHFR, ITGB3, IL6, F8, PLAT
50lipid446.6CRP, F8, IL6, SERPINE1, APOH, TNF

GO Terms for genes affiliated with Retinal Artery Occlusion

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Cellular components related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6F5, F8, SERPINE1
2external side of plasma membraneGO:0098978.2THY1, TNF, ACE, IL6
3extracellular regionGO:0055766.6F2, F9, TNF, SERPINE1, SERPINC1, ACE
4plasma membraneGO:0058866.3TNF, F9, THY1, F2, SERPINE1, SERPINC1
5extracellular spaceGO:0056156.1HMOX1, F2, TNF, APOH, SERPINE1, SERPINC1

Biological processes related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 31)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.2APOH, PLAT
2smooth muscle cell migrationGO:01490910.2PLAT, ITGB3
3positive regulation of chemokine biosynthetic processGO:04508010.2HMOX1, TNF
4negative regulation of blood coagulationGO:03019510.1APOH, SERPINE1
5negative regulation of fibrinolysisGO:05191810.1SERPINE1, APOH, F2
6peptidyl-glutamic acid carboxylationGO:01718710.1F2, F9
7positive regulation of blood coagulationGO:03019410.1F2, APOH, SERPINE1
8receptor biosynthetic processGO:03280010.0IL10, TNF
9negative regulation of cytokine secretion involved in immune responseGO:00274010.0IL10, TNF
10fibrinolysisGO:04273010.0PLAT, SERPINE1, F2
11negative regulation of macrophage derived foam cell differentiationGO:0107459.9ITGB3, CRP
12epithelial cell proliferation involved in salivary gland morphogenesisGO:0606649.8IL6, TNF
13positive regulation of protein phosphorylationGO:0019349.8ITGB3, TNF, F2
14negative regulation of proteolysisGO:0458619.8F2, PLAT
15platelet degranulationGO:0025769.7SERPINE1, ITGB3, F8, F5
16negative regulation of growth of symbiont in hostGO:0441309.7IL10, TNF
17negative regulation of interleukin-6 productionGO:0327159.7IL10, TNF
18negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:19020429.7HMOX1, SERPINE1
19blood coagulation, intrinsic pathwayGO:0075979.6F2, F9, APOH, F8
20positive regulation of smooth muscle cell proliferationGO:0486619.6TNF, IL6, HMOX1
21positive regulation of chemokine productionGO:0327229.6IL6, TNF
22response to hypoxiaGO:0016669.6TNF, MTHFR, PLAT, CRP
23defense response to Gram-positive bacteriumGO:0508309.5TNF, IL6, CRP
24positive regulation of sequence-specific DNA binding transcription factor activityGO:0510919.3IL6, IL10, TNF
25negative regulation of lipid storageGO:0108889.3CRP, IL6, ITGB3, TNF
26acute-phase responseGO:0069539.2F2, IL6, F8, CRP
27response to glucocorticoidGO:0513849.1PLAT, IL6, IL10, TNF
28response to drugGO:0424939.1TNF, MTHFR, IL10, IL6
29inflammatory responseGO:0069548.9TNF, IL10, IL6, CRP
30platelet activationGO:0301688.9F2, SERPINE1, ITGB3, IL6, F8, F5
31blood coagulationGO:0075968.6F2, F9, SERPINE1, SERPINC1, ITGB3, F8

Molecular functions related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.7SERPINC1, SERPINE1, TNF
2serine-type endopeptidase activityGO:0042528.7F2, F9, F8, PLAT, F5
3protein bindingGO:0055155.0F5, F2, THY1, TNF, APOH, SERPINE1

Products for genes affiliated with Retinal Artery Occlusion

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  • Antibodies
  • Proteins
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Sources for Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet