MCID: RTN014
MIFTS: 45

Retinal Artery Occlusion

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Retinal Artery Occlusion

MalaCards integrated aliases for Retinal Artery Occlusion:

Name: Retinal Artery Occlusion 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8483
MeSH 41 D015356
NCIt 46 C34978
SNOMED-CT 64 232035005
UMLS 69 C0035302

Summaries for Retinal Artery Occlusion

MalaCards based summary : Retinal Artery Occlusion is related to branch retinal artery occlusion and homocystinuria, and has symptoms including amaurosis fugax An important gene associated with Retinal Artery Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Ranibizumab and insulin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 branch retinal artery occlusion 33.6 APOH F2 MTHFR SERPINC1
2 homocystinuria 29.9 F5 MTHFR SERPINC1
3 amaurosis fugax 29.9 F5 MTHFR SERPINE1
4 endocarditis 29.8 APOH F2 SERPINC1
5 infective endocarditis 29.6 APOH F2 SERPINE1
6 purpura 29.6 APOH F2 SERPINC1
7 central retinal vein occlusion 29.5 APOH F2 F5 MTHFR SERPINC1
8 sneddon syndrome 29.5 APOH F2 F5 SERPINC1
9 nonarteritic anterior ischemic optic neuropathy 29.5 ACE F2 F5 MTHFR SERPINC1
10 patent foramen ovale 29.5 APOH F2 F5 MTHFR SERPINC1
11 antiphospholipid syndrome 29.4 APOH F2 F5 MTHFR SERPINC1
12 arteritic anterior ischemic optic neuropathy 29.3 ACE F2 F5 MTHFR
13 protein s deficiency 29.3 APOH F2 F5 MTHFR SERPINC1
14 coronary artery anomaly 29.3 ACE MTHFR SERPINE1
15 catastrophic antiphospholipid syndrome 29.1 APOH F5 MTHFR SERPINE1
16 retinal vein occlusion 29.1 APOH F2 F5 MTHFR SERPINC1 SERPINE1
17 ischemic optic neuropathy 29.1 ACE APOH F2 F5 MTHFR SERPINC1
18 buerger disease 29.1 APOH F2 MTHFR SERPINE1
19 arteries, anomalies of 29.0 ACE F2 MTHFR SERPINC1 SERPINE1
20 retinal vascular occlusion 28.9 APOH F2 F5 MTHFR SERPINC1
21 livedoid vasculopathy 28.7 APOH F2 F5 MTHFR SERPINE1
22 thrombosis 28.4 APOH F2 F5 MTHFR SERPINC1 SERPINE1
23 stroke, ischemic 28.1 ACE APOH F2 F5 MTHFR SERPINC1
24 myocardial infarction 27.9 ACE F2 F5 F8 MTHFR SERPINC1
25 thrombophilia 27.9 APOH F2 F5 F8 MTHFR SERPINC1
26 central retinal artery occlusion 12.7
27 transient retinal arterial occlusion 12.4
28 partial arterial retinal occlusion 11.6
29 retinitis 11.1
30 paracetamol poisoning 10.4 F2 F5
31 may-thurner syndrome 10.4 APOH F5
32 acanthamoeba keratitis 10.4 APOH F5
33 mesenteric vascular occlusion 10.4 F2 MTHFR
34 hemoglobin e disease 10.4 F2 F5
35 neuropathy 10.4
36 ischemic neuropathy 10.4 F2 MTHFR
37 splenic infarction 10.3 APOH F2
38 papilledema 10.3 APOH F2
39 intestinal impaction 10.3 F2 SERPINC1
40 acquired hemophilia a 10.3 F5 F8
41 leech infestation 10.3 F2 SERPINC1
42 scott syndrome 10.3 F2 F5
43 acquired hemophilia 10.3 F5 F8
44 alpha-2-plasmin inhibitor deficiency 10.3 F2 SERPINC1
45 factor v and factor viii, combined deficiency of, 2 10.3 F5 F8
46 giant hemangioma 10.3 F2 SERPINC1
47 intracranial embolism 10.3 F2 SERPINC1
48 acute liver failure 10.3 F2 F5
49 hepatoportal sclerosis 10.3 ACE F2
50 anterior spinal artery syndrome 10.3 F2 SERPINC1

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to Retinal Artery Occlusion

Symptoms & Phenotypes for Retinal Artery Occlusion

UMLS symptoms related to Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Artery Occlusion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 MTHFR SERPINC1 ACE SERPINE1 APOH F2
2 cardiovascular system MP:0005385 9.8 HMOX1 SERPINC1 ACE SERPINE1 F2 F5
3 mortality/aging MP:0010768 9.61 MTHFR SERPINC1 ACE SERPINE1 APOH F2
4 liver/biliary system MP:0005370 9.55 HMOX1 SERPINC1 ACE SERPINE1 F5
5 reproductive system MP:0005389 9.1 HMOX1 MTHFR SERPINC1 ACE F2 F8

Drugs & Therapeutics for Retinal Artery Occlusion

Drugs for Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4 347396-82-1 459903
2 insulin Phase 4
3 Angiogenesis Inhibitors Phase 4
4 Angiogenesis Modulating Agents Phase 4
5 Insulin, Globin Zinc Phase 4
6
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
7
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
8
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
9
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
10 Neurotransmitter Agents Phase 3,Phase 2
11 Analgesics Phase 3
12 Fibrinolytic Agents Phase 3
13 Tissue Plasminogen Activator Phase 3
14 Cyclooxygenase Inhibitors Phase 3
15 Analgesics, Non-Narcotic Phase 3
16 Peripheral Nervous System Agents Phase 3
17 Pharmaceutical Solutions Phase 3
18 Plasminogen Phase 3
19 Platelet Aggregation Inhibitors Phase 3
20 Anti-Inflammatory Agents Phase 3
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Antipyretics Phase 3
23 Antirheumatic Agents Phase 3
24 calcium heparin Phase 3
25 diuretics Phase 3
26 Adrenergic Agents Phase 3
27 Adrenergic Antagonists Phase 3
28 Adrenergic beta-Antagonists Phase 3
29 Natriuretic Agents Phase 3
30 Anticoagulants Phase 3
31 Anticonvulsants Phase 3
32 Carbonic Anhydrase Inhibitors Phase 3
33
Adenosine Approved, Investigational Phase 2 58-61-7 60961
34
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
35
Bevacizumab Approved, Investigational 216974-75-3
36 Tetrahydrozoline
37 Ophthalmic Solutions

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Not yet recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
6 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
7 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
8 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
9 OCT in Rare Chorioretinal Diseases Unknown status NCT02141308
10 Spectral-domain Optical Coherence Tomography of the Eye Unknown status NCT02614625
11 Ocular Discomfort Assessment After Intravitreal Injections Completed NCT02806830 Optive
12 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
13 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
14 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
15 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Recruiting NCT03061526
16 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
17 Investigation of Biomarkers in Susac Syndrome Recruiting NCT01273792
18 Optical Coherence Tomography Angiography Examinations in Chronic Retinal Artery Occlusion Active, not recruiting NCT03357146
19 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Active, not recruiting NCT02679716
20 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Active, not recruiting NCT02898480
21 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
22 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
23 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

Anatomical Context for Retinal Artery Occlusion

MalaCards organs/tissues related to Retinal Artery Occlusion:

38
Eye, Retina, Brain, Thyroid, T Cells, Lung

Publications for Retinal Artery Occlusion

Articles related to Retinal Artery Occlusion:

(show top 50) (show all 773)
# Title Authors Year
1
Branch retinal artery occlusion post-penetrating globe injury with intraocular foreign body. ( 29283146 )
2018
2
Optical Coherence Tomography-Based Angiography in Retinal Artery Occlusion in Children. ( 29393247 )
2018
3
Current treatment of central retinal artery occlusion: a national survey. ( 29236169 )
2018
4
Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion. ( 29358594 )
2018
5
Ophthalmic artery MRI in an arteritis-related central retinal artery occlusion. ( 29358510 )
2018
6
Branch retinal artery occlusion as a clinical manifestation of hereditary haemorrhagic telangiectasia (Osler-Weber-Rendu syndrome) in pregnancy. ( 29068144 )
2018
7
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29378380 )
2018
8
Differentiating Occult Branch Retinal Artery Occlusion from Primary Open-angle Glaucoma. ( 29370018 )
2018
9
Thrombus in Lamina Cribrosa Seen Using Swept-Source Optical Coherence Tomography in Eye With Central Retinal Artery Occlusion. ( 29360684 )
2018
10
Visibility of Blood Flow on Optical Coherence Tomography Angiography in a Case of Branch Retinal Artery Occlusion. ( 29403595 )
2018
11
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017
12
Hyperbaric oxygen in the treatment of acute retinal artery occlusion. ( 29241233 )
2017
13
Is Intravenous Thrombolysis Safe and Effective in Central Retinal Artery Occlusion? A Critically Appraised Topic. ( 28644261 )
2017
14
Retinal artery occlusion and associated recurrent vascular risk with underlying etiologies. ( 28570629 )
2017
15
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
16
Expression of angiogenic mediators in a patient with a retinal artery occlusion. ( 28774531 )
2017
17
Central Retinal Artery Occlusion by Left Atrial Myxoma. ( 28243029 )
2017
18
Optical Coherence Tomography Angiography of a Central Retinal Artery Occlusion Before and After Anterior Chamber Paracentesis. ( 28433123 )
2017
19
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
20
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome Presenting With Branch Retinal Artery Occlusion. ( 29121367 )
2017
21
Perioperative Retinal Artery Occlusion: Incidence and Risk Factors in Spinal Fusion Surgery From the US National Inpatient Sample 1998-2013. ( 28665867 )
2017
22
Central retinal artery occlusion in a 30-year-old woman taking tranexamic acid. ( 28705840 )
2017
23
A Framework for Classification and Segmentation of Branch Retinal Artery Occlusion in SD-OCT. ( 28459688 )
2017
24
Triamcinolone emboli leading to central retinal artery occlusion: a multimodal imaging study. ( 28228436 )
2017
25
Bilateral Central Retinal Artery Occlusion Associated with Bilateral Lymphoproliferative Infiltrative Optic Neuropathy. ( 29071274 )
2017
26
Central retinal artery occlusion without underlying chronic ocular ischemic syndrome may lead to neovascular glaucoma. ( 29055729 )
2017
27
PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH RETINAL ARTERY OCCLUSION AFTER COSMETIC FILLER INJECTION. ( 27763945 )
2017
28
The efficacy of hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 28500127 )
2017
29
Central retinal artery occlusion after percutaneous nephrolithotomy lithotripsy in the prone position. ( 28097535 )
2017
30
Combined branch retinal vein and branch retinal artery occlusion - clinical features, systemic associations, and outcomes. ( 28440254 )
2017
31
Retinal Artery Occlusion Secondary to Buerger's Disease (Thromboangiitis Obliterans). ( 28491481 )
2017
32
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
33
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
34
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
35
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
36
Multimodal Images of Acute Central Retinal Artery Occlusion. ( 29348953 )
2017
37
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
38
Traumatic optic neuropathy and central retinal artery occlusion following blunt trauma to the eyebrow. ( 29264089 )
2017
39
Treatment of retinal artery occlusion using transluminal Nd:YAG laser: a systematic review and meta-analysis. ( 28823062 )
2017
40
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
41
Disappearance of Myelinated Retinal Nerve Fibers after Central Retinal Artery Occlusion Reveals Nettleship Collaterals. ( 28823346 )
2017
42
Hyperbaric, Central Retinal Artery Occlusion ( 28613728 )
2017
43
Combined Central Retinal Vein and Branch Retinal Artery Occlusion Post Intense Physical Activity. ( 29067224 )
2017
44
Rescue vitrectomy with blocked artery massage and bloodletting for branch retinal artery occlusion. ( 28513500 )
2017
45
Systemic intravenous abciximab: a novel treatment for acute central retinal artery occlusion? ( 28470954 )
2017
46
Carotid cavernous fistula with central retinal artery occlusion and Terson syndrome after mid-facial trauma. ( 28580223 )
2017
47
Incidental branch retinal artery occlusion on optical coherence tomography angiography presenting as segmental optic atrophy in a child: a case report. ( 29258533 )
2017
48
Fundus autofluorescence in retinal artery occlusion: A more precise diagnosis. ( 28882392 )
2017
49
RETINAL ARTERY OCCLUSION AFTER INTRAVASCULAR PROCEDURES: Case Series and Literature Review. ( 29266046 )
2017
50
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017

Variations for Retinal Artery Occlusion

Expression for Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for Retinal Artery Occlusion

GO Terms for Retinal Artery Occlusion

Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE APOH F2 F5 F8 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.46 F2 F5 F8 SERPINC1
3 COPII-coated ER to Golgi transport vesicle GO:0030134 9.32 F5 F8
4 extracellular space GO:0005615 9.23 ACE APOH F2 F5 F8 HMOX1
5 platelet alpha granule lumen GO:0031093 9.13 F5 F8 SERPINE1

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.71 F2 F5 F8 SERPINC1
2 cellular protein metabolic process GO:0044267 9.67 F2 F5 SERPINC1
3 platelet degranulation GO:0002576 9.67 APOH F5 F8 SERPINE1
4 ER to Golgi vesicle-mediated transport GO:0006888 9.65 F2 F5 F8
5 blood circulation GO:0008015 9.54 F5 MTHFR
6 acute-phase response GO:0006953 9.52 F2 F8
7 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.51 HMOX1 SERPINE1
8 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
9 fibrinolysis GO:0042730 9.46 F2 SERPINE1
10 negative regulation of blood coagulation GO:0030195 9.43 APOH SERPINE1
11 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F2 F8
12 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
13 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
14 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....