MCID: RTN014
MIFTS: 44

Retinal Artery Occlusion malady

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Artery Occlusion

Aliases & Descriptions for Retinal Artery Occlusion:

Name: Retinal Artery Occlusion 12 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8483
MeSH 42 D015356
NCIt 47 C34978
SNOMED-CT 64 232035005
UMLS 69 C0035302

Summaries for Retinal Artery Occlusion

MalaCards based summary : Retinal Artery Occlusion is related to central retinal artery occlusion and lupus erythematosus, and has symptoms including amaurosis fugax An important gene associated with Retinal Artery Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Aspirin and Dipyridamole have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
id Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 33.9 APOH F2 MTHFR SERPINC1
2 lupus erythematosus 30.1 ACE SERPINC1
3 ischemic optic neuropathy 29.7 ACE APOH F2 SERPINC1 SERPINE1
4 atherosclerosis 29.7 APOH HMOX1
5 essential thrombocythemia 29.4 F2 F8 SERPINC1
6 myocardial infarction 28.7 ACE F2 F5 F8 MTHFR SERPINC1
7 branch retinal artery occlusion 12.5
8 transient retinal arterial occlusion 12.2
9 partial arterial retinal occlusion 11.2
10 retinitis 11.1
11 neuropathy 10.3
12 scn8a-related epilepsy with encephalopathy 10.3 F2 MTHFR
13 porphyria 10.3 F2 MTHFR
14 multiple familial trichoepithelioma 10.2 F5 MTHFR
15 miller-dieker lissencephaly syndrome 10.2 F2 SERPINC1
16 landau-kleffner syndrome 10.2 APOH F2
17 influenza 10.2 F2 SERPINC1
18 congenital insensitivity to pain with severe intellectual disability 10.2 F2 F5
19 prostatitis 10.2 APOH F2
20 med13l syndrome 10.2 APOH F5
21 chorioretinal scar 10.2 F2 SERPINC1
22 mixed hepatoblastoma 10.2 F2 SERPINC1
23 peanut allergy 10.2 F2 SERPINC1
24 achard thiers syndrome 10.2 APOH F5
25 dmd-related dilated cardiomyopathy 10.2 F2 SERPINC1
26 oxyphilic adenoma 10.2 F2 F5
27 schwannoma of jugular foramen 10.2 F2 SERPINC1
28 retinal vein occlusion 10.2
29 kartagener syndrome 10.2 ACE MTHFR
30 familial progressive hyperpigmentation 10.2 ACE F2
31 cerebellar astrocytoma 10.2 F2 SERPINC1
32 angelucci's syndrome 10.2 F2 SERPINC1
33 pars planitis 10.2 ACE MTHFR
34 ovarian papillary cystadenoma 10.2 F2 SERPINC1
35 carbohydrate metabolic disorder 10.2 ACE SERPINC1
36 epstein-barr virus hepatitis 10.2 F2 SERPINC1
37 neutropenia 10.2 MTHFR SERPINE1
38 cerebritis 10.2
39 melorheostosis 10.1 ACE SERPINC1
40 mixed epithelial tumor of ovary 10.1 F2 MTHFR SERPINC1
41 ductal carcinoma in situ 10.1 F2 MTHFR SERPINC1
42 myopia 10.1 ACE F2
43 capillary hemangioma 10.1 F2 MTHFR SERPINC1
44 photosensitive epilepsy 10.1 F2 F5 MTHFR
45 may-hegglin anomaly 10.1 APOH F2 SERPINC1
46 brazilian hemorrhagic fever 10.1 SERPINC1 SERPINE1
47 houlston ironton temple syndrome 10.1 F2 F5 MTHFR
48 gastrointestinal defects and immunodeficiency syndrome 10.1 F5 MTHFR
49 lung cancer 10.1 APOH F5 MTHFR
50 susac syndrome 10.1

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to Retinal Artery Occlusion

Symptoms & Phenotypes for Retinal Artery Occlusion

UMLS symptoms related to Retinal Artery Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Artery Occlusion:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 ACE APOH F2 F5 F8 HMOX1
2 cardiovascular system MP:0005385 9.8 ACE F2 F5 HMOX1 SERPINC1 SERPINE1
3 mortality/aging MP:0010768 9.61 ACE APOH F2 F5 F8 HMOX1
4 liver/biliary system MP:0005370 9.55 F5 HMOX1 SERPINC1 SERPINE1 ACE
5 reproductive system MP:0005389 9.1 ACE F2 F8 HMOX1 MTHFR SERPINC1

Drugs & Therapeutics for Retinal Artery Occlusion

Drugs for Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3 50-78-2 2244
2
Dipyridamole Approved Phase 4 58-32-2 3108
3
Ranibizumab Approved Phase 4 347396-82-1 459903
4 Rosuvastatin Calcium Phase 4 147098-20-2
5 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
6 Hypolipidemic Agents Phase 4
7 Fibrinolytic Agents Phase 4,Phase 3,Phase 1
8 Anticholesteremic Agents Phase 4
9 Lipid Regulating Agents Phase 4
10 Antimetabolites Phase 4
11 Calcium, Dietary Phase 4
12 insulin Phase 4
13 Analgesics Phase 4,Phase 3
14 Cyclooxygenase Inhibitors Phase 4,Phase 3
15 Analgesics, Non-Narcotic Phase 4,Phase 3
16 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
17 Vasodilator Agents Phase 4,Phase 2
18 Phosphodiesterase Inhibitors Phase 4,Phase 2
19 Platelet Aggregation Inhibitors Phase 4,Phase 3
20 Insulin, Globin Zinc Phase 4
21 Anti-Inflammatory Agents Phase 4,Phase 3
22 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
23 Antipyretics Phase 4,Phase 3
24 Antirheumatic Agents Phase 4,Phase 3
25 Angiogenesis Inhibitors Phase 4
26 Angiogenesis Modulating Agents Phase 4
27
Vorapaxar Approved Phase 3 618385-01-6
28
Ethanol Approved Phase 3 64-17-5 702
29
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
30
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
31 Neurotransmitter Agents Phase 3,Phase 2
32 calcium heparin Phase 3
33 diuretics Phase 3
34 Adrenergic Agents Phase 3
35 Natriuretic Agents Phase 3
36 Adrenergic Antagonists Phase 3
37 Adrenergic beta-Antagonists Phase 3
38 Anticoagulants Phase 3
39 Anticonvulsants Phase 3
40 Carbonic Anhydrase Inhibitors Phase 3
41
Papaverine Approved Phase 2 61-25-6, 58-74-2 4680
42
Adenosine Approved, Investigational Phase 2 58-61-7 60961
43
Regadenoson Approved Phase 2 313348-27-5 219024
44 Moxaverine Phase 2
45 Parasympatholytics Phase 2
46 Autonomic Agents Phase 2
47 Tissue Plasminogen Activator Phase 1
48 Plasminogen Phase 1
49
Triamcinolone Approved, Vet_approved 124-94-7 31307
50
Dipivefrin Approved 52365-63-6 3105

Interventional clinical trials:

(show all 42)
id Name Status NCT ID Phase
1 The Prediction of Extent and Risk Profile of Coronary Atherosclerosis and Their Changes During Lipid-lowering Therapy Based on Non-invasive Techniques Unknown status NCT01773512 Phase 4
2 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4
3 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4
4 Ranibizumab and the Risk of Arterial Thromboembolic Events Terminated NCT01319188 Phase 4
5 Trial to Assess the Ocular Safety of Vorapaxar (SCH 530348) in Participants With Atherosclerosis (Study P05183) Completed NCT00617123 Phase 3
6 Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients(EXCAVATION-CHN1) Recruiting NCT02817204 Phase 3
7 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3
8 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
9 Hyperbaric Chamber for Central Retinal Vein Occlusion (CRVO) Patients Unknown status NCT02405741 Phase 2
10 Effects of Moxaverine and Placebo on Ocular Blood Flow Completed NCT00709423 Phase 2
11 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2
12 Intraocular Pressure During Prone Spinal Surgery Terminated NCT00176722 Phase 2
13 Intra-arterial Thrombolysis for Severe Recent Central Retinal Vein Occlusion Unknown status NCT01581411 Phase 1
14 Intravitreal Aflibercept Injection for Symptomatic Macular Edema From Retinal Artery Macroaneurysms Recruiting NCT02403128 Phase 1
15 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
16 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
17 OCT in Rare Chorioretinal Diseases Unknown status NCT02141308
18 Transcorneal Electrical Stimulation Therapy for Retinal Disease Completed NCT00804102
19 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion Completed NCT00612261
20 Study of Methodologies to Measure Blood Flow and Oxygenation in Adults With Sickle Cell Disease Completed NCT02447627
21 Insulin Resistance and Atherosclerosis in Women With Lupus Completed NCT00544102
22 Autonomic Nervous System Activity and Normal Tension Glaucoma Completed NCT01192061
23 Retinal Arteriolar Abnormalities and CV Mortality Completed NCT00011167
24 Multi-Ethnic Study of Atherosclerosis (MESA) - Ancillary Eye Study Completed NCT00041444
25 Reconstruction of Pathological Changes of the Ophthalmic Artery in Patients With Retinal Artery Occlusion Recruiting NCT02679716
26 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
27 Ocular Discomfort Assessment After Intravitreal Injections Recruiting NCT02806830
28 Spectral-domain Optical Coherence Tomography of the Eye Recruiting NCT02614625
29 Epidemiological, Clinical and Etiological Features of SUSAC's Syndrome Recruiting NCT01481662
30 Investigation of Biomarkers in Susac Syndrome Recruiting NCT01273792
31 Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A) Recruiting NCT02811536
32 Retinal Thrombosis and Atherosclerosis Recruiting NCT02257333
33 Exercise, Arterial Cross-Talk Modulation and Inflammation in an Ageing Population Recruiting NCT02796976
34 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245
35 Retrospective Data Analysis of Patients Treated for Macular Edema Due to Central Retinal Vein Occlusion Active, not recruiting NCT02645747
36 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650
37 Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning Not yet recruiting NCT02898480
38 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Not yet recruiting NCT03061526
39 Evaluation of the Capacity of a Camera to Identify Signs of Arteriosclerosis in Retinal Arterioles Not yet recruiting NCT02849405
40 Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma Not yet recruiting NCT02955524
41 Ocular Effects of Carotid Endarterectomy Not yet recruiting NCT02448355
42 Comparison of Phase-variance Optical Coherence Tomography and Fluorescein Angiography in Retinovascular Imaging Terminated NCT01717937

Search NIH Clinical Center for Retinal Artery Occlusion

Genetic Tests for Retinal Artery Occlusion

Anatomical Context for Retinal Artery Occlusion

MalaCards organs/tissues related to Retinal Artery Occlusion:

39
Eye, Retina, Brain, Thyroid, Lung, T Cells, Breast

Publications for Retinal Artery Occlusion

Articles related to Retinal Artery Occlusion:

(show top 50) (show all 721)
id Title Authors Year
1
CENTRAL RETINAL ARTERY OCCLUSION WITH DOUBLE CILIORETINAL ARTERY SPARING. ( 28085758 )
2017
2
Evaluation of Ophthalmic Artery Branch Retrograde Intervention in the Treatment of Central Retinal Artery Occlusion (CRAO). ( 28064304 )
2017
3
Management of acute central retinal artery occlusion: Intravenous thrombolysis is feasible and safe. ( 28067616 )
2017
4
PARACENTRAL ACUTE MIDDLE MACULOPATHY AND DEEP RETINAL CAPILLARY PLEXUS INFARCTION SECONDARY TO REPERFUSED CENTRAL RETINAL ARTERY OCCLUSION. ( 27668500 )
2017
5
PARACENTRAL ACUTE MIDDLE MACULOPATHY ASSOCIATED WITH RETINAL ARTERY OCCLUSION AFTER COSMETIC FILLER INJECTION. ( 27763945 )
2017
6
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
7
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
8
Central retinal artery occlusion and cerebral infarction associated with Mycoplasma pneumonia infection in children. ( 27938350 )
2016
9
Risk of Retinal Artery Occlusion in Patients With End-Stage Renal Disease: A Retrospective Large-Scale Cohort Study. ( 27057891 )
2016
10
Branch retinal artery occlusion following carotid stenting: A case report. ( 27698708 )
2016
11
Manifestations of central retinal artery occlusion revealed by fundus fluorescein angiography are associated with the degree of visual loss. ( 27313672 )
2016
12
Branched Retinal Artery Occlusions and Susac Syndrome. ( 27159123 )
2016
13
Associations of retinal artery occlusion and retinal vein occlusion to mortality, stroke, and myocardial infarction: a systematic review. ( 27256303 )
2016
14
Two-Year Follow-up of a Prepapillary Vascular Loop-Related Branch Retinal Artery Occlusion. ( 26869129 )
2016
15
Central Retinal Artery Occlusion and Cerebral Infarction Following Stem Cell Injection for Baldness. ( 27941403 )
2016
16
STRANGULATION-INDUCED CENTRAL RETINAL ARTERY OCCLUSION: CASE REPORT AND REVIEW OF THE LITERATURE. ( 27337704 )
2016
17
Regional Changes in Choroidal Thickness in Branch Retinal Artery Occlusion. ( 27631476 )
2016
18
Retinal artery occlusion as an announcement of stroke and myocardial infarction? ( 27553349 )
2016
19
Central Retinal Artery Occlusion With Subsequent Central Retinal Vein Occlusion in Biopsy-Proven Giant Cell Arteritis. ( 27261946 )
2016
20
A Rare Cause of Retinal Artery Occlusion in Severe Hypernatremic Dehydration in Newborns. ( 27183555 )
2016
21
CENTRAL RETINAL ARTERY OCCLUSION IN A YOUNG HIV-INFECTED PATIENT ON HIGHLY ACTIVE ANTIRETROVIRAL THERAPY. ( 27111556 )
2016
22
Combined central retinal vein and branch retinal artery occlusion in hyperhomocysteinaemia. ( 27974343 )
2016
23
Branch Retinal Artery Occlusion Imaged With Spectral-Domain Optical Coherence Tomographic Angiography. ( 27078016 )
2016
24
Central Retinal Artery Occlusion: A Literature Review and the Rationale for Hyperbaric Oxygen Therapy. ( 27039492 )
2016
25
Mean platelet volume in patients with retinal artery occlusion. ( 26840159 )
2016
26
Central Retinal Artery Occlusion in Takayasu's Arteritis as the First Presentation of the Disease. ( 27867673 )
2016
27
Central retinal artery occlusion as a presenting manifestation of polycythaemia vera. ( 27797860 )
2016
28
CORRELATION OF OPTICAL INTENSITY ON OPTICAL COHERENCE TOMOGRAPHY AND VISUAL OUTCOME IN CENTRAL RETINAL ARTERY OCCLUSION. ( 26966866 )
2016
29
Comment on: mean platelet volume in patients with retinal artery occlusionResponse: comment on: mean platelet volume in patients with retinal artery occlusionMean platelet volume in patients with retinal artery occlusion. ( 27626159 )
2016
30
Central retinal artery occlusion after phacoemulsification under peribulbar anaesthesia: Pathogenic hypothesis. ( 26652970 )
2016
31
Cerebral Small Vessel Disease in Branch Retinal Artery Occlusion. ( 27802487 )
2016
32
Retinal artery occlusion due to Bartonella henselae infection: a case series. ( 26748767 )
2016
33
Retinal artery occlusion by left atrial myxoma misdiagnosed as thrombus. ( 27064439 )
2016
34
Perioperative Retinal Artery Occlusion: Risk Factors in Cardiac Surgery from the United States National Inpatient Sample 1998-2013. ( 27914836 )
2016
35
The Characteristics of Retinal Emboli and its Association With Vascular Reperfusion in Retinal Artery Occlusion. ( 27598864 )
2016
36
Spectral-Domain Optical Coherence Tomography Angiography of Central Retinal Artery Occlusion. ( 27183551 )
2016
37
Observation on therapeutic efficacy of rt-PA intravenous thrombolysis combined with compound anisodine injection on central retinal artery occlusion. ( 27698763 )
2016
38
Central Retinal Artery Occlusion in a Teenager. ( 27012699 )
2016
39
Visual Improvement after Intra-Arterial Thrombolysis for Central Retinal Artery Occlusion Does Not Correlate with Time to Treatment. ( 27781041 )
2016
40
Retinal Arterioarterial Anastomosis After Embolic Branch Retinal Artery Occlusion. ( 27548352 )
2016
41
Branch retinal artery occlusion in a patient with one eye. Laser Nd:YAG approach. ( 26896065 )
2016
42
Comparison of hyperbaric oxygen versus iloprost treatment in an experimental rat central retinal artery occlusion model. ( 27480178 )
2016
43
Embolic Central Retinal Artery Occlusion Detected with Point-of-care Ultrasonography in the Emergency Department. ( 26879704 )
2016
44
Ambient Air Pollution and the Risk of Central Retinal Artery Occlusion. ( 27745901 )
2016
45
Retinal Artery Occlusion and the Risk of Stroke Development: Twelve-Year Nationwide Cohort Study. ( 26742801 )
2016
46
Multimodal imaging of central retinal artery occlusion with retained cilioretinal perfusion. ( 27530879 )
2016
47
Central Retinal Artery Occlusion Masquerading as Branch Retinal Artery Occlusion. ( 27729760 )
2016
48
Optical Coherence Tomography Angiography of Retinal Artery Occlusion. ( 27023788 )
2016
49
Early Onset of Ocular Neovascularization After Hyperbaric Oxygen Therapy in a Patient With Central Retinal Artery Occlusion. ( 27613631 )
2016
50
Selective Thrombophilia Screening in Young Patients with Retinal Artery Occlusion. ( 27173060 )
2016

Variations for Retinal Artery Occlusion

Expression for Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for Retinal Artery Occlusion

GO Terms for Retinal Artery Occlusion

Cellular components related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE APOH F2 F5 F8 SERPINC1
2 endoplasmic reticulum lumen GO:0005788 9.46 F2 F5 F8 SERPINC1
3 ER to Golgi transport vesicle GO:0030134 9.32 F5 F8
4 extracellular space GO:0005615 9.23 ACE APOH F2 F5 F8 HMOX1
5 platelet alpha granule lumen GO:0031093 9.13 F5 F8 SERPINE1

Biological processes related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.85 ACE F2 F5 F8
2 blood coagulation GO:0007596 9.71 F2 F5 F8 SERPINC1
3 cellular protein metabolic process GO:0044267 9.69 F2 F5 SERPINC1
4 platelet degranulation GO:0002576 9.67 APOH F5 F8 SERPINE1
5 ER to Golgi vesicle-mediated transport GO:0006888 9.65 F2 F5 F8
6 platelet activation GO:0030168 9.61 F2 F5 F8
7 blood circulation GO:0008015 9.56 F5 MTHFR
8 acute-phase response GO:0006953 9.54 F2 F8
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.52 HMOX1 SERPINE1
10 regulation of blood coagulation GO:0030193 9.5 APOH F2 SERPINC1
11 fibrinolysis GO:0042730 9.49 F2 SERPINE1
12 negative regulation of blood coagulation GO:0030195 9.46 APOH SERPINE1
13 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F2 F8
14 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
15 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
16 hemostasis GO:0007599 8.92 F2 F5 F8 SERPINC1

Molecular functions related to Retinal Artery Occlusion according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.13 F2 F5 F8
2 heparin binding GO:0008201 8.8 APOH F2 SERPINC1

Sources for Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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