MCID: RTN014
MIFTS: 53

Retinal Artery Occlusion malady

Summaries for Retinal Artery Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Artery Occlusion is related to central retinal artery occlusion and branch retinal artery occlusion. An important gene associated with Retinal Artery Occlusion is SERPINC1 (serpin peptidase inhibitor, clade C (antithrombin), member 1), and among its related pathways are Platelet activation, signaling and aggregation and Dissolution of Fibrin Clot. The compounds aspartate and coumarins have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are respiratory system and integument.

Aliases & Classifications for Retinal Artery Occlusion

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8Disease Ontology, 44Novoseek, 60UMLS, 34MeSH, 39NCIt, 56SNOMED-CT
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Aliases & Descriptions:

retinal artery occlusion 8 44 60


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Disease Ontology8 DOID:8483
MeSH34 D015356
SNOMED-CT56 232035005
NCIt39 C34978

Related Diseases for Retinal Artery Occlusion

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17GeneCards, 18GeneDecks
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Diseases in the Central Retinal Artery Occlusion family:

retinal artery occlusion

Diseases related to Retinal Artery Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 270)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal artery occlusion32.1SLC17A8, PLAT
2branch retinal artery occlusion31.7F5, PSD
3retinal vein occlusion31.0SERPINC1, MTHFR, F5, APOH
4central retinal vein occlusion30.9PLAT, MTHFR, APOH, F5
5sickle cell disease30.7HMOX1, F9
6retinal vasculitis30.7APOH
7lupus erythematosus30.7APOH, F5, F2, SERPINC1
8vasculitis30.7F2, APOH, TNF
9patent foramen ovale30.6F5
10systemic lupus erythematosus30.6IL10, F2, F8, TNF, APOH
11hyperhomocysteinemia30.6SERPINC1, SERPINE1, PLAT, F2, MTHFR, F5
12migraine30.6APOH, MTHFR
13retinal vascular occlusion30.6F5, APOH
14antiphospholipid syndrome30.6APOH, SERPINC1, PLAT, F2, MTHFR, F5
15protein s deficiency30.5SERPINC1, F9, F5
16acquired immunodeficiency syndrome30.3F8
17homocystinuria30.3F5, SERPINC1, MTHFR
18ischemia30.3PLAT, HMOX1
19hepatitis30.3F2, F8, F9
20hepatitis c30.3F2, IL10, TNF
21purpura30.1SERPINC1
22ovarian hyperstimulation syndrome30.1F5
23cryoglobulinemia30.1APOH
24adenocarcinoma30.1HMOX1
25crohn's disease30.1TNF
26sneddon syndrome30.1APOH, SERPINC1
27endophthalmitis30.1PLAT
28deficiency anemia30.1F9, F2
29hepatitis a30.1F2, F8
30pneumonia30.1TNF, HMOX1, IL10
31hemorrhagic disease30.1F2, F8, SERPINC1, F9, F5
32breast cancer30.1PLAT, MTHFR, ITGB3, F9, HMOX1, SERPINE1
33myocardial infarction30.1SERPINE1, PLAT, F9, F8, ITGB3, F5
34atherosclerosis30.1MTHFR, PLAT, IL10, HMOX1, SERPINE1, SERPINC1
35thrombophilia30.1F2, MTHFR, F5, F8, APOH, F9
36retinitis11.5
37retinal disease10.9
38carotid artery occlusion10.8
39neuropathy10.8
40ischemic neuropathy10.6
41transient retinal arterial occlusion10.6
42ischemic optic neuropathy10.6
43glaucoma10.6
44churg-strauss syndrome10.6
45carotid artery dissection10.5
46wegener's granulomatosis10.5
47neovascular glaucoma10.4
48carotid artery disease10.4
49partial arterial retinal occlusion10.4
50carotid stenosis10.4

Graphical network of the top 20 diseases related to Retinal Artery Occlusion:



Diseases related to retinal artery occlusion

Clinical Features for Retinal Artery Occlusion

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Drugs & Therapeutics for Retinal Artery Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Retinal Artery Occlusion

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Anatomical Context for Retinal Artery Occlusion

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32MalaCards
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MalaCards organs/tissues related to Retinal Artery Occlusion:

32
Eye, Retina, Brain, Thyroid, Bone, Breast, T cells

Animal Models for Retinal Artery Occlusion or affiliated genes

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36MGI
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Publications for Retinal Artery Occlusion

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50PubMed
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Articles related to Retinal Artery Occlusion:

(show top 50)    (show all 609)
idTitleAuthorsYear
1
Central retinal artery occlusion caused by fat embolism following endoscopic sinus surgery. (23571187)
2013
2
Central retinal artery occlusion in a 13-year-old child as a presenting sign of hyperhomocysteinemia together with high lipoprotein(a) level. (23859863)
2013
3
A review of central retinal artery occlusion: clinical presentation and management. (23470793)
2013
4
Carbogen in the management of a central retinal artery occlusion. (23256429)
2012
5
Bilateral central retinal artery occlusions in an infant with hyperhomocysteinemia. (22819238)
2012
6
Central retinal artery occlusion secondary to orbital cellulitis and abscess following dacryocystitis. (21462155)
2011
7
Hyoid bone compression-induced repetitive occlusion and recanalization of the internal carotid artery in a patient with ipsilateral brain and retinal ischemia. (21320995)
2011
8
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
9
Optical coherence tomography findings in acute phase of branch retinal artery occlusion: case report. (20549053)
2010
10
Central retinal vein occlusion with cilioretinal infarction from branch flow exclusion and choroidal arterial steal. (19898176)
2009
11
Branch retinal vein occlusion followed by central retinal artery occlusion in Churg-Strauss syndrome: unusual ocular manifestations in allergic granulomatous angiitis. (19253257)
2009
12
Thrombolysis for acute central retinal artery occlusion: is it time? (18984082)
2008
13
Changes in retinal thickness are correlated with alterations of electroretinogram in eyes with central retinal artery occlusion. (18425524)
2008
14
Systemic diseases in non-inflammatory branch and central retinal artery occlusion--an overview of 416 patients. (18024271)
2007
15
Intra-arterial thrombolysis for central retinal artery occlusion in United States: Nationwide In-patient Survey 2001-2003. (17894624)
2007
16
Intraretinal oxygen distribution and consumption during retinal artery occlusion and graded hyperoxic ventilation in the rat. (17460293)
2007
17
Unilateral postoperative visual loss due to central retinal artery occlusion following cervical spine surgery in prone position. (17596227)
2007
18
The fate of patients with retinal artery occlusion and Hollenhorst plaque. (17950567)
2007
19
Preserved vision despite distinct retinal edema in central retinal artery occlusion. (16504960)
2006
20
Activation of the mitochondrial apoptotic pathway in a rat model of central retinal artery occlusion. (15914634)
2005
21
Retinal arterial occlusion in Takayasu's arteritis. (16137966)
2005
22
Visual functions following recovery from non-arteritic central retinal artery occlusion. (15088819)
2004
23
Posterior scleritis causing combined central retinal artery and vein occlusion. (15187677)
2004
24
Unilateral central retinal artery occlusion followed by contralateral anterior ischemic optic neuropathy. (15377812)
2004
25
Commotio-retinae and central retinal artery occlusion after blunt ocular trauma. (15004594)
2004
26
Sudden painless unilateral vision loss caused by branch retinal artery occlusion: implications for the primary care physician. (14722396)
2004
27
Branch retinal artery occlusions as the presenting feature of primary central nervous system vasculitis. (15675139)
2004
28
Translumenal Nd:YAG laser embolysis for branch retinal artery occlusion. (11927856)
2002
29
Central retinal artery occlusion caused by expansion of intraocular gas at high altitude. (12383821)
2002
30
Neovascular glaucoma associated with cilioretinal artery occlusion combined with perfused central retinal vein occlusion. (12062227)
2002
31
Branch retinal artery obstruction with simultaneous central retinal vein occlusion. (11339596)
2001
32
Multifocal electroretinograms in patients with branch retinal artery occlusion. (11583676)
2001
33
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: an experimental study in rhesus monkeys. (10926989)
2000
34
Ocular massage in a case of central retinal artery occlusion the successful treatment of a hitherto undescribed type of embolism. (10799350)
2000
35
Spontaneous central retinal artery occlusion in hemoglobin sickle cell disease. (10844071)
2000
36
Vitreous surgery for central retinal artery occlusion. (11074821)
2000
37
Branch retinal artery occlusion in systemic diseases: a case report. (10355155)
1999
38
Aggressive systematic treatment for central retinal artery occlusion. (10612510)
1999
39
Superselective fibrinolysis in central retinal artery occlusion. (8781602)
1996
40
Branch retinal artery occlusion in pregnancy. (8297878)
1994
41
Haemorheological parameters in patients with retinal artery occlusion and anterior ischaemic optic neuropathy. (1540556)
1992
42
Central retinal artery occlusion after local anesthesia for blepharoplasty. (1765303)
1991
43
A case of sudden retinal artery occlusion and blindness in pregnancy. (3808517)
1987
44
Central retinal artery occlusion in Sneddon's disease associated with antiphospholipid antibodies. (3524244)
1986
45
Relationship of extracranial carotid occlusive disease and central retinal artery occlusion. (3740355)
1986
46
Central retinal artery occlusion following transfemoral cerebral angiography. (4014930)
1985
47
Rheologic findings in patients with acute central retinal artery occlusion. (6862190)
1983
48
Retinal telangiectasia secondary to bilateral carotid artery occlusion. (6349594)
1983
49
THE HISTOPATHOLOGY OF EARLY CENTRAL RETINAL ARTERY OCCLUSION. (14270137)
1965
50
Neuromedical and ophthalmic aspects of central retinal artery occlusion. (13931064)
1962

Genetic Variations for Retinal Artery Occlusion

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Expression for genes affiliated with Retinal Artery Occlusion

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Artery Occlusion

Search GEO for disease gene expression data for Retinal Artery Occlusion.

Pathways for genes affiliated with Retinal Artery Occlusion

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53Reactome, 51QIAGEN, 4Cell Signaling Technology, 37NCBI BioSystems Database, 29KEGG, 52R&D Systems
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Compounds for genes affiliated with Retinal Artery Occlusion

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44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 158)
idCompoundScoreTop Affiliating Genes
1aspartate4410.3F8, F2
2coumarins4410.3F9, APOH
3warfarin44 49 11 2413.3SERPINC1, APOH, F9
4spectrozyme4410.1F2, F5, SERPINC1, PLAT
5estrogen4410.0F9, APOH, F8
6cyclophosphamide44 49 1112.0APOH, F5, F8, MTHFR
7bivalirudin44 1111.0F2, F5, SERPINC1, PLAT
8argatroban44 1111.0SERPINC1, PLAT, F2, F5
9batroxobin4410.0F2, SERPINE1, PLAT, F5
10protamine sulfate4410.0F2, PLAT, SERPINC1, F5
11inogatran449.9SERPINC1, F2, F5
12p-amino benzamidine449.9SERPINC1, F9, SERPINE1, PLAT
13Drotrecogin alfa119.9F8, F5, SERPINE1, F2
14tirofiban44 1110.8F2, ITGB3, SERPINC1, PLAT
15ancrod449.8F5, PLAT, SERPINE1, SERPINC1, F2
16cyclosporin a44 28 5911.8HMOX1, F2, F8, F9
17fondaparinux449.8PLAT, SERPINC1, F2, F5, F9
18aprotinin44 1110.8SERPINC1, F9, F5, PLAT, SERPINE1
19heparin44 28 11 2412.7SERPINA10, F9, APOH, F8, MTHFR
20kaolin449.7F2, F8, APOH, F9, F5
21protamine449.7SERPINE1, SERPINC1, PLAT, F5, F2
22epsilon aminocaproic acid449.7SERPINE1, F2, PLAT, SERPINC1, F9
23creatinine449.7F5, F2, F9, APOH, F8
24gabexate mesilate449.7F5, SERPINC1, IL10, PLAT, TNF
25levonorgestrel44 59 28 1112.7SERPINC1, F2, PLAT, F5
26dermatan sulfate449.7SERPINC1, PLAT, F2, F5, F9
27phosphatidylserine44 28 1111.7F2, ITGB3, APOH, F8
28phosphatidylethanolamine44 1110.6F2, F8, F5, F9, APOH
29serine449.6TNF, F9, F8, SERPINA10
308-isoprostane449.6HMOX1, SERPINE1, IL10, TNF, APOH
31pge1449.5PLAT, F2, F5, SERPINE1, APOH
32tranexamic acid44 1110.4F2, PLAT, F8, SERPINE1, F9, SERPINC1
33citrate449.4F2, F5, F9, F8, HMOX1, SERPINC1
34kininogen449.4SERPINC1, PLAT, F2, SERPINE1, APOH, F5
35ristocetin449.3F2, F5, ITGB3, F8, PLAT, SERPINC1
36ivig449.3IL10, APOH, F8, TNF, F9
37atorvastatin44 49 28 11 2413.3TNF, F5, IL10, HMOX1, PLAT, SERPINE1
38desmopressin44 59 28 1112.3SERPINE1, F9, F8, F5, F2, PLAT
39hirudin449.3F8, F9, F2, F5, PLAT, SERPINE1
40rituximab44 49 1111.2IL10, APOH, TNF, F9, F8
41simvastatin44 49 59 28 11 2414.1SERPINE1, HMOX1, PLAT, IL10, F2, F5
42endotoxin449.0SERPINE1, F5, IL10, APOH, TNF, F8
43methotrexate44 49 1110.9TNF, APOH, MTHFR, IL10, F2, SERPINE1
44homocysteine44 249.9MTHFR, F5, F8, APOH, F9, F2
45aspirin44 49 28 2411.7APOH, F8, ITGB3, F5, MTHFR, F2
46prostacyclin448.7SERPINC1, SERPINE1, HMOX1, PLAT, IL10, F8
47alanine448.7HMOX1, SERPINC1, MTHFR, F2, F5, SERPINA10
48vegf448.6TNF, F5, HMOX1, SERPINE1, F8, IL10
49fibrinogen448.4F9, TNF, APOH, F8, ITGB3, F5
50cholesterol44 28 11 2411.4PLAT, ROM1, APOH, MTHFR, F5, SERPINE1

GO Terms for genes affiliated with Retinal Artery Occlusion

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16Gene Ontology
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Cellular components related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5F5, SERPINE1, F8
2extracellular matrixGO:0310129.2APOH, EMILIN1, PLAT, SERPINE1
3extracellular regionGO:0055768.1SERPINC1, F9, SERPINE1, PLAT, F2, EMILIN1
4extracellular spaceGO:0056157.9APOH, SERPINE1, SERPINC1, HMOX1, PLAT, F2
5plasma membraneGO:0058867.8SERPINC1, SERPINE1, THY1, F2, F8, ITGB3

Biological processes related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1smooth muscle cell migrationGO:01490910.3ITGB3, PLAT
2plasminogen activationGO:03163910.2APOH, PLAT
3negative regulation of lipid storageGO:01088810.2ITGB3, TNF
4receptor biosynthetic processGO:03280010.1IL10, TNF
5negative regulation of fibrinolysisGO:05191810.1SERPINE1, F2, APOH
6positive regulation of blood coagulationGO:03019410.1APOH, F2, SERPINE1
7negative regulation of cytokine secretion involved in immune responseGO:00274010.1TNF, IL10
8positive regulation of chemokine biosynthetic processGO:04508010.1HMOX1, TNF
9negative regulation of endopeptidase activityGO:01095110.1SERPINC1, SERPINE1, SERPINA10
10negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.1SERPINE1, HMOX1
11fibrinolysisGO:04273010.1SERPINE1, PLAT, F2
12negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH
13peptidyl-glutamic acid carboxylationGO:01718710.0F2, F9
14platelet degranulationGO:0025769.9F8, ITGB3, F5, SERPINE1
15blood coagulation, intrinsic pathwayGO:0075979.8F9, APOH, F8, F2
16response to glucocorticoid stimulusGO:0513849.8TNF, IL10, PLAT
17platelet activationGO:0301689.6SERPINE1, F2, F5, ITGB3, F8
18positive regulation of protein phosphorylationGO:0019349.5F2, ITGB3, TNF
19cell adhesionGO:0071559.4ROM1, EMILIN1, F5, ITGB3, F8
20extracellular matrix organizationGO:0301989.2TNF, ITGB3, EMILIN1, SERPINE1
21blood coagulationGO:0075968.8SERPINC1, F9, F8, ITGB3, F5, F2

Molecular functions related to Retinal Artery Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.9SERPINA10, SERPINE1, SERPINC1
2protease bindingGO:0020209.5TNF, SERPINE1, SERPINC1
3protein bindingGO:0055156.6TNF, APOH, PSD, F8, ITGB3, F5

Products for genes affiliated with Retinal Artery Occlusion

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  • Antibodies
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Sources for Retinal Artery Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet