Retinal Degeneration malady

MalaCards: Retinal Degeneration, also known as degeneration of retina (disorder), is related to peripheral retinal degeneration and leber congenital amaurosis. An important gene associated with Retinal Degeneration is PRPH2 (peripherin 2 (retinal degeneration, slow)), and among its related pathways are Visual Cycle in Retinal Rods and Phototransduction. The compounds 11-cis-retinol and threonine have been mentioned in the context of this disorder. Affiliated tissues include cortex, retina and kidney, and related mouse phenotypes are pigmentation and reproductive system.

Aliases & Descriptions:

retinal degeneration 6 7 17 8 32 43 degeneration of retina (disorder) 6

abnormal degeneration 43 retina degeneration 6

Diseases related to retinal degeneration by text searches and GeneDecks gene sharing:

(show top 50)    (show all 226)

id	Related Disease	Score	Top Affiliating Genes
1	peripheral retinal degeneration	34.6	CLN5, CLN3, RPGR, PRPH2, PRPH, ROM1
2	leber congenital amaurosis	32.7	LRAT, RD3, RDH12, RDH8, SERPINF1, MYO7A
3	age related macular degeneration	32.5	RDH8, SERPINF1, CLU, BEST1, GUCA1A, FGF2
4	spinocerebellar ataxia type 7	32.5	ATXN1, ATN1, ATXN7, CRX
5	macular degeneration	32.4	CNTF, RDH8, SERPINF1, CLU, BEST1, ATXN7
6	cerebellar ataxia	31.5	PAX6, ATXN1, ATN1, ATXN7, TMEM67, TBP
7	night blindness	30.5	LRAT, RDH5, RBP3, CHM, SAG, GRK1
8	macular dystrophy	30.3	RDH5, BEST1, BEST2, ATXN1, ATXN7, GUCA1A
9	choroiditis	30.0	CNTF, RCVRN, SERPINF1, BMP6, USH2A, BEST1
10	stickler syndrome	29.9	RDH8, SERPINF1, PAX6, CHM, SAG, OAT
11	enhanced s-cone syndrome	29.8	GRK1, NR2E3, NRL, CRX
12	choroideremia	29.7	RAB6A, RABGGTB, RABGGTA, CHM, ARSA, ABCA4
13	retinal disease	29.7	LRAT, CNGB1, CNTF, RDH12, RDH5, MYO7A
14	olivopontocerebellar atrophy	29.2	ATXN1, ATN1, ATXN7, GLUD1, TBP
15	nephronophthisis	29.1	CEP290, TMEM67, RPGRIP1L, RPGRIP1, RPGR, PKD1
16	blindness	29.1	LRAT, CNGB1, CNTF, RDH12, RDH5, RCVRN
17	retinitis	29.0	LRAT, PDE2A, PDE3B, RERE, CNGB1, CNTF
18	ataxia	28.3	RERE, RCVRN, USH1C, USH2A, PAX6, CEP290
19	polycystic kidney disease	28.1	CLU, JUN, GNB3, TMEM67, PKD1, PKD2
20	glaucoma	27.8	CNTF, SERPINF1, BMP6, RAB8A, CLU, BEST1
21	neuronitis	24.9	PDE2A, PDE3B, CNGB1, CNTF, RCVRN, SERPINF1
22	cerebritis	24.3	CNTF, BMP6, CLN5, CLN3, PAX6, BDNF
23	fibrosis	23.6	BMP6, CLU, BEST1, BBS1, BBS7, XBP1
24	obesity	23.6	PDE3B, CNTF, SERPINF1, BMP6, CLU, PAX6
25	hepatitis	22.3	LRAT, PDE3B, CNTF, SERPINF1, BMP6, RAB8A
26	cone dystrophy	14.6	RDH5, RCVRN, SERPINF1, BEST1, GUCA1A, GUCY2D
27	pigmentary retinopathy	14.6	RDH12, USH2A, BEST1, PANK2, CHM, BBS1
28	rhyns syndrome	14.5	RDH12, UNC119, LCA5, CEP290, CERKL, ATXN7
29	fundus dystrophy	14.4	LRAT, RDH12, RDH5, RDH8, BEST1, BBS1
30	chorioretinitis	14.3	RBP3, SERPINF1, PAX6, CHM, SAG, OAT
31	hyperopia	14.3	LRAT, MYO7A, GUCY2D, MFRP, IMPDH1, TULP1
32	retinitis punctata albescens	14.3	RDH5, RDH8, RBP3, RHO, PRPH2, ROM1
33	fundus albipunctatus	14.3	RDH5, RDH8, RBP3, SAG, GRK1, RPE65
34	partial central choroid dystrophy	14.3	UNC119, GUCA1A, GUCY2D, PITPNA, ABCA4, TIMP3
35	choroidal dystrophy	14.2	RCVRN, SERPINF1, ARRB2, AIPL1, PITPNA, TIMP3
36	keratoconus	14.2	LRAT, SERPINF1, MYO7A, GUCY2D, IMPDH1, ENO1
37	congenital stationary night blindness	14.2	RDH5, GRK1, RPE65, PDE6B, RHO
38	fundus flavimaculatus	14.2	ABCA4, PRPH2, ROM1, RLBP1
39	nystagmus	14.2	LRAT, MYO7A, PAX6, GRK1, IMPDH1, TULP1
40	maculopathy	14.1	SERPINF1, BEST1, BBS1, MTTP, AKR1B1, AIPL1
41	vitelliform macular dystrophy	14.1	BEST1, BEST2, ABCA4, PRPH2, ROM1
42	retinol binding protein	14.1	LRAT, RDH12, RDH5, RBP3, SAG, NTF3
43	retinitis pigmentosa 7	14.1	RHO, PRPH2, ROM1
44	hereditary night blindness	14.1	RDH5, SAG, GRK1, RHO
45	coloboma	14.1	RDH12, PAX6, LCA5, CEP290, GUCY2D, AIPL1
46	mckusick-kaufman syndrome	14.1	BBS1, BBS2, BBS4, BBS7, MKKS
47	laurence-moon syndrome	14.0	BBS2, MKKS, RPGRIP1, RPGR
48	usher syndrome	14.0	MYO7A, USH1C, USH2A, LCA5, CDH23, GNAT2
49	chorioretinal atrophy	14.0	SERPINF1, CHM, CRB1, COL2A1, C1QTNF5
50	scotoma	14.0	UNC119, GUCY2D, ABCA4, PRPH, PRPF3

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to retinal degeneration:

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MGI Mouse Phenotypes related to retinal degeneration:

²⁵ (show all 22)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	pigmentation phenotype	MP:0001186	10.6	SERPINF1, MYO7A, RABGGTA, BEST1, PAX6, UNC119
2	reproductive system phenotype	MP:0005389	9.8	PKD1, SMPD3, NRTN, PPP5C, GNAZ, MERTK
3	taste/olfaction phenotype	MP:0005394	9.8	MKKS, BBS4, BBS2, BBS1, BDNF, PAX6
4	endocrine/exocrine gland phenotype	MP:0005379	9.7	TUB, NRTN, SMPD3, PKD2, PITPNA, GLUD1
5	renal/urinary system phenotype	MP:0005367	9.2	COL2A1, PKD1, PKD2, TIMP3, NPHP1, NPHP3
6	hematopoietic system phenotype	MP:0005397	9.1	DKK3, TGFBI, HEPH, ELOVL4, PPP5C, DGKZ
7	immune system phenotype	MP:0005387	8.3	TIMP3, TSPAN32, GFAP, PKD2, PKD1, COL2A1
8	behavior/neurological phenotype	MP:0005386	8.0	CNTF, MYO7A, USH1C, DGKE, GDNF, PSIP1
9	cardiovascular system phenotype	MP:0005385	7.8	PKD2, PDE6B, RHO, NDP, C1QTNF5, PKD1
10	normal phenotype	MP:0002873	7.7	PKD1, COL2A1, CREBBP, PPP5C, PPEF1, PPEF2
11	homeostasis/metabolism phenotype	MP:0005376	6.6	MERTK, SPHK2, SPHK1, NTF3, SMPD3, CRB1
12	growth/size phenotype	MP:0005378	6.5	NTF4, PPP5C, SMPD3, CREBBP, CRYAB, RPGRIP1L
13	vision/eye phenotype	MP:0005391	INF	HEPH, SLC1A1, CP, ROM1, RORB, RLBP1
14	embryogenesis phenotype	MP:0005380	INF	TMEM67, TBP, SPHK2, SPHK1, PPP4C, CREBBP
15	muscle phenotype	MP:0005369	INF	CRYAB, CREBBP, NRTN, NTF3, SPHK1, PKD1
16	cellular phenotype	MP:0005384	INF	TSPAN32, GFAP, RHO, PDE6B, PITPNA, PKD2
17	craniofacial phenotype	MP:0005382	INF	RPGRIP1L, CRYAB, CREBBP, HSPG2, COL2A1, PKD1
18	digestive/alimentary phenotype	MP:0005381	INF	PKD1, COL2A1, CRYAB, CREBBP, NRTN, PKD2
19	nervous system phenotype	MP:0003631	INF	GRK1, SPHK2, SPHK1, NTF3, NTF4, NR2E3
20	mortality/aging	MP:0010768	INF	NTF4, PPP4C, PPP5C, SMPD3, CRB1, CREBBP
21	skeleton phenotype	MP:0005390	INF	CRYAB, RPGRIP1L, COL2A1, PKD1, NDP, TTC21B
22	hearing/vestibular/ear phenotype	MP:0005377	INF	FGF2, HSPG2, CALB1, TUB, TULP1, COL2A1

Articles related to retinal degeneration:

(show top 50)    (show all 163)

id	Title	Authors	Year	Affiliating Genes
1	TOPORS, implicated in retinal degeneration, is a cili a-centrosomal protein. (21159800)	Chakarova C.F.... Bhattacharya S.S.	2011	TOPORS
2	Functional analysis of BBS3 A89V that results in non- syndromic retinal degeneration. (21282186)	Pretorius P.R.... Slusarski D.C.	2011	ARL6
3	Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. (19765607)	Zhu D.... Kannan R.	2010	SPHK1, SPHK2, CERK
4	Gene therapy in the retinal degeneration slow model o f retinitis pigmentosa. (20238065)	Cai X.... Naash M.I.	2010	PRPH2
5	CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. (20209167)	Li Y.... Wen R.	2010	CNTF, ARR3
6	Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations. (19710705)	Sun X.... Li T.	2010	AIPL1, GRK1
7	RPGR-containing protein complexes in syndromic and no n-syndromic retinal degeneration due to ciliary dysfunction. (20090203)	Murga-Zamalloa C.A.... Khanna H.	2009	RPGRIP1, RPGR
8	A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies. (19430481)	Khanna H.... Katsanis N.	2009	RPGRIP1, RPGR, RPGRIP1L
9	Overexpression of a mutant form of TGFBI/BIGH3 induce s retinal degeneration in transgenic mice. (18568131)	Bustamante M.... Schorderet D.F.	2008	TGFBI
10	A missense mutation in the nuclear localization signal sequence of CERKL (p.R106S) causes autosomal recessive retinal degeneration. (18978954)	Ali M.... Inglehearn C.F.	2008	CERKL
11	Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila. (19074021)	Ni L.... Li H.S.	2008	RHO
12	Intrafamilial clinical heterogeneity associated with a novel mutation of the retinal degeneration slow/peripherin gene. (17851265)	Simonelli F.... Bandello F.	2007	PRPH
13	Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function. (17174953)	Ishiba Y.... Inana G.	2007	UNC119
14	The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals. (17251446)	Zhang Q.... Guo X.	2007	FSCN2
15	Paradoxical opsin expressing cells in the inner retin a that are augmented following retinal degeneration. (17445228)	Semo M.... Jeffery G.	2007	OPN4
16	A novel form of transducin-dependent retinal degeneration: accelerated retinal degeneration in the absence of rod transducin. (18055791)	Brill E.... Lem J.	2007	RHO, GNAZ
17	Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. (16505355)	Sieving P.A.... Bush R.A.	2006	CNTF
18	Autoantibodies to p75/LEDGF, a cell survival factor, found in patients with atypical retinal degeneration. (16757148)	Chin M.S.... Hooks J.J.	2006	PSIP1
19	Biochemical characterisation of the C1QTNF5 gene associated with late-onset retinal degeneration. A genetic model of age-related macular degeneration. (17249553)	Shu X.... Wright A.F.	2006	C1QTNF5
20	Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration. (15610977)	Wenzel A.... Reme C.E.	2005	ENDOG
21	Towards mutation-independent silencing of genes involved in retinal degeneration by RNA interference. (15877050)	Cashman S.M.... Kumar-Singh R.	2005	RHO
22	Cellular mechanisms of retinal degenerations: RPE65, ABCA4, RDS, and bicarbonate transporter genes as examples. (16374319)	Bok D.	2005	RPE65, ABCA4
23	Surmountable challenges in translating pigment epithelium-derived factor (PEDF) therapy from animal models to clinical trials for retinal degenerations. (16374323)	Chader G.J.	2005	SERPINF1
24	Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1. (15634774)	Huttl S.... Biel M.	2005	CNGB1
25	Constitutive opsin signaling: night blindness or retinal degeneration? (15059605)	Lem J.... Fain G.L.	2004	RHO
26	Factors that affect regulation of cGMP synthesis in vertebrate photoreceptors and their genetic link to human retinal degeneration. (11952089)	Olshevskaya E.V.... Dizhoor A.M.	2002	GUCY2D, GUCA1A
27	Role of Muller cells in retinal degenerations. (11578954)	Bringmann A.... Reichenbach A.	2001	BMP6
28	The mammalian retinal degeneration B2 gene is not required for photoreceptor function and survival. (11744244)	Lu C.... Li T.	2001	PITPNM1
29	A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. (10587575)	Maw M.A.... Denton M.J.	2000	PROM1
30	A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse. (10805811)	Akhmedov N.B.... Farber D.B.	2000	NR2E3
31	A neuronal-specific mammalian homolog of the Drosophila retinal degeneration B gene with expression restricted to the retina and dentate gyrus. (10460238)	Lu C.... Li T.	1999	PITPNM1
32	Repeated injections of a ciliary neurotrophic factor analogue leading to long-term photoreceptor survival in hereditary retinal degeneration. (10235570)	Chong N.H.... Luthert P.J.	1999	BDNF, CNTF
33	Retinal degeneration in tulp1-/- mice: vesicular accumulation in the interphotoreceptor matrix. (10549638)	Hagstrom S.A.... Li T.	1999	RHO, TULP1
34	Identification of a novel family of targets of PYK2 related to Drosophila retinal degeneration B (rdgB) protein. (10022914)	Lev S.... Schlessinger J.	1999	PTK2B, PITPNM1, NOC2L
35	A novel retinal degeneration locus identified by linkage and comparative mapping of canine early retinal degeneration. (10409424)	Acland G.M.... Aguirre G.D.	1999	RHO, PDE2A, PDE6B
36	Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations. (10393054)	Gao Y.Q.... Farber D.B.	1999	PDE6C
37	Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion. (9425224)	Del-Favero J.... Van Broeckhoven C.	1998	ATXN7
38	Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. (9326663)	Sherman P.M.... Nathans J.	1997	PPEF1, PPEF2
39	Cloning and characterization of human homologue of Drosophila retinal degeneration B: a candidate gene for degenerative retinal diseases. (9216063)	Guo J.... Yu F.X.	1997	PITPNM1
40	A mouse model of gyrate atrophy of the choroid and retina. Early retinal pigment epithelium damage and progressive retinal degeneration. (8675686)	Wang T.... Valle D.	1996	OAT
41	A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration. (7862413)	Gorin M.B.... Stone E.M.	1995	PRPH2
42	Chromosomal localization of three mouse diacylglycerol kinase (DAGK) genes: genes sharing sequence homology to the Drosophila retinal degeneration A (rdgA) gene. (7607687)	Pilz A.... Fitzgibbon J.	1995	DGKQ
43	Autosomal-dominant cerebellar ataxia with retinal degeneration (ADCA type II) is genetically different from ADCA type I. (8154871)	Benomar A.... Brice A.	1994	RHO
44	Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy. (8485576)	Wells J.... Fitzke F.	1993	PRPH2
45	Retinal degeneration in choroideremia: deficiency of rab geranylgeranyl transferase. (8380507)	Seabra M.C.... Goldstein J.L.	1993	CHM, RABGGTA, RABGGTB
46	Calcium channel blockers inhibit retinal degeneration in the retinal-degeneration-B mutant of Drosophila. (1309615)	Sahly I.... Minke B.	1992	PITPNM1
47	Multiple sulfatase deficiency with early severe retinal degeneration. (1875023)	Harbord M.... Clarke J.T.	1991	ARSA, GALNS, ARSH
48	The human retinal degeneration slow (RDS) gene: chromosome assignment and structure of the mRNA. (1679750)	Travis G.H.... Sutcliffe G.J.	1991	PRPH2
49	Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant. (2361011)	Steele F.... O'Tousa J.E.	1990	RHO
50	Identification of a photoreceptor-specific mRNA encoded by the gene responsible for retinal degeneration slow (rds). (2918924)	Travis G.H.... Sutcliffe J.G.	1989	PRPH2

Genes related to retinal degeneration according to GeneCards:

(show top 50)    (show all 198)

id	Symbol	Description	Score	GeneCards Section Context
1	PRPH2	peripherin 2 (retinal degeneration, slow)	11.1	Publications, Transcripts, Aliases & Descriptions, Orthologs (show all 5 sections) Summaries
2	PITPNM1	phosphatidylinositol transfer protein, membrane-associated 1	11.1	Summaries, Orthologs, Aliases & Descriptions, Publications
3	RD3	retinal degeneration 3	11.1	Transcripts, Summaries, Publications, Aliases & Descriptions (show all 5 sections) Orthologs
4	ATXN7	ataxin 7	11.1	Aliases & Descriptions, Publications, Summaries
5	PITPNM2	phosphatidylinositol transfer protein, membrane-associated 2	11.1	Aliases & Descriptions, Orthologs, Summaries, Publications
6	C1QTNF5	C1q and tumor necrosis factor related protein 5	11.1	Summaries, Publications
7	ROM1	retinal outer segment membrane protein 1	11.1	Summaries
8	PITPNC1	phosphatidylinositol transfer protein, cytoplasmic 1	11.1	Aliases & Descriptions, Orthologs
9	RP2	retinitis pigmentosa 2 (X-linked recessive)	11.1	Summaries
10	MYO7A	myosin VIIA	11.1	Summaries
11	PRCD	progressive rod-cone degeneration	11.1	Summaries
12	PPEF2	protein phosphatase, EF-hand calcium binding domain 2	11.1	Summaries, Orthologs, Publications
13	PPEF1	protein phosphatase, EF-hand calcium binding domain 1	11.1	Publications, Functions, Summaries, Orthologs
14	BBS7	Bardet-Biedl syndrome 7	11.1	Summaries
15	DGKI	diacylglycerol kinase, iota	11.1	Orthologs, Summaries
16	PITPNM3	PITPNM family member 3	11.0	Publications, Aliases & Descriptions
17	RD3L	retinal degeneration 3-like	11.0	Aliases & Descriptions
18	BBS10	Bardet-Biedl syndrome 10	11.0	Summaries
19	MPP5	membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)	11.0	Summaries
20	ATXN1	ataxin 1	11.0	Summaries
21	NRL	neural retina leucine zipper	11.0	Publications
22	MFRP	membrane frizzled-related protein	11.0	Publications
23	CLN3	ceroid-lipofuscinosis, neuronal 3	11.0
24	RPGR	retinitis pigmentosa GTPase regulator	11.0	Publications
25	TULP1	tubby like protein 1	11.0	Publications
26	UNC119	unc-119 homolog (C. elegans)	11.0	Publications
27	CLN5	ceroid-lipofuscinosis, neuronal 5	11.0
28	PRPH	peripherin	11.0	Publications
29	NR2E3	nuclear receptor subfamily 2, group E, member 3	11.0	Publications
30	FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)	11.0	Publications
31	RHO	rhodopsin	11.0	Publications
32	RPE65	retinal pigment epithelium-specific protein 65kDa	11.0	Publications
33	OPN4	opsin 4	11.0	Publications
34	AIPL1	aryl hydrocarbon receptor interacting protein-like 1	11.0	Publications
35	PDE6G	phosphodiesterase 6G, cGMP-specific, rod, gamma	11.0
36	FRZB	frizzled-related protein	11.0	Publications
37	TULP2	tubby like protein 2	11.0
38	NRTN	neurturin	11.0	Publications
39	RP1	retinitis pigmentosa 1 (autosomal dominant)	11.0	Publications
40	RDH5	retinol dehydrogenase 5 (11-cis/9-cis)	11.0
41	PROM2	prominin 2	11.0
42	MCOLN1	mucolipin 1	11.0
43	RPGRIP1	retinitis pigmentosa GTPase regulator interacting protein 1	11.0	Publications
44	RCVRN	recoverin	11.0	Publications
45	CRX	cone-rod homeobox	11.0	Publications
46	SFRP2	secreted frizzled-related protein 2	11.0	Publications
47	GUCA1B	guanylate cyclase activator 1B (retina)	11.0
48	RLBP1	retinaldehyde binding protein 1	11.0	Publications
49	PDE6B	phosphodiesterase 6B, cGMP-specific, rod, beta	11.0	Publications
50	RBP3	retinol binding protein 3, interstitial	11.0	Publications

Pathways related to retinal degeneration according to GeneDecks:

(show all 28)

id	Pathway	Score	Top Affiliating Genes
1	Visual Cycle in Retinal Rods36	11.1	LRAT, GNAT2, GNAZ, PPEF2, RPE65, PDE6B
2	Phototransduction20	10.9	RHO, PDE6G, PDE6B, GNAT2, GRK1, ARRB2
3	Glycerolipid metabolism20	10.7	DGKZ, DGKQ, DGKI, DGKE, DGKB, AKR1B1
4	Retinol metabolism41	10.6	LRAT, RDH12, RDH5, RPE65, RHO
5	Platelet activation, signaling and aggregation38	10.6	DGKZ, DGKQ, DGKI, DGKE, DGKB
6	Sphingolipid metabolism20	10.5	ACER2, SMPD3, SPHK1, SPHK2, ARSA, CERK
7	Relaxin Pathway36	10.2	GNB3, GNAZ, GNAT2, GUCY2D, JUN, PDE3B
8	Neuroscience3	9.9	SLC1A3, PSIP1, GFAP, RHO, TUBA1B, GLUD1
9	Actin-Based Motility by Rho Family GTPases36	9.7	GNB3, GNAZ, GNAT2, BDNF
10	ERK Signaling36	9.5	PSIP1, COL2A1, PTK2B, HSPG2, GNAZ, GNAT2
11	Protein Acetylation and Deacetylation36	9.5	EP300, TAF12, TAF9, TAF5L, CREBBP, TBP
12	Histone modification10	9.3	TAF12, TAF9, TAF5L, TADA3, SUPT3H, TRRAP
13	eNOS Signaling36	9.1	NUDT6, PRKAA1, PSIP1, NTF3, GNB3, MERTK
14	Rho Family GTPases36	9.0	PTK2B, NTF3, COL2A1, GFAP, TIMP3, PSIP1
15	ERK5 Signaling36	9.0	NUDT6, PSIP1, TIMP3, NTF3, GNB3, GNAZ
16	ILK Signaling36	8.9	NUDT6, PSIP1, TIMP3, COL2A1, NTF3, PTK2B
17	Activation of PKC through GPCR36	8.9	GNB3, NTF3, TIMP3, PSIP1, NUDT6, GNAZ
18	MAPK Signaling36	8.9	PTK2B, NTF3, COL2A1, TIMP3, PSIP1, NUDT6
19	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes41	8.7	SUPT3H, CREBBP, TADA3, TAF5L, TAF9, TADA2A
20	Transcription Ligand-Dependent Transcription of Retinoid-Target genes10	8.7	EP300, TBP, SUPT3H, CREBBP, TADA3, TAF5L
21	Activation of PKA through GPCR36	8.4	GNB3, NTF3, CREBBP, TIMP3, PSIP1, NUDT6
22	IP3 Pathway36	8.4	CREBBP, TIMP3, PSIP1, NUDT6, EP300, NTF3
23	CREB Pathway36	8.2	EP300, NUDT6, PSIP1, TIMP3, CREBBP, NTF3
24	Intracellular Calcium Signaling36	8.2	NTF3, CREBBP, TIMP3, PSIP1, NUDT6, EP300
25	Phospholipase-C Pathway36	8.2	CREBBP, COL2A1, TIMP3, PSIP1, NUDT6, EP300
26	cAMP Pathway36	8.2	GNB3, PTK2B, NTF3, CREBBP, TIMP3, PSIP1
27	Nuclear Receptor Activation by Vitamin-A36	8.1	TAF9, TAF12, PSIP1, NUDT6, EP300, TAF5L
28	Estrogen Pathway36	8.0	CREBBP, TIMP3, TAF5L, TAF9, TAF12, PSIP1

Compounds related to retinal degeneration according to GeneDecks:

(show top 50)    (show all 91)

id	Compound	Score	Top Affiliating Genes
1	11-cis-retinol32 18	12.1	LRAT, RDH5, RBP3, RPE65, RHO, ABCA4
2	threonine32	10.8	MKKS, ARR3, ARRB2, GRK1, GLUD1, PPEF1
3	guanylate32	10.8	PDE2A, PDE3B, RCVRN, SERPINF1, SAG, GUCA1A
4	r 59-02242	10.8	DGKB, DGKE, DGKI, DGKQ, DGKZ
5	dioctanoylglycol42	10.7	DGKB, DGKE, DGKI, DGKQ, DGKZ
6	cgmp32	10.6	PDE2A, PDE3B, CNGB1, RCVRN, SAG, GUCA1A
7	vitamin a32 9 18 9	13.6	LRAT, RDH12, RDH5, RDH8, RBP3, SAG
8	gtp32	10.5	PDE2A, PDE3B, RAB6A, CHM, GUCY2D, GRK1
9	ceramide32	10.4	PDE3B, CLN3, CERK, JUN, ARSA, ENDOG
10	fatty acid32	9.9	PDE3B, RCVRN, RBP3, CLU, MTTP, TUBA1B
11	retinoid32	9.9	LRAT, RDH5, RBP3, BMP6, SAG, JUN
12	lipid32	9.9	PDE3B, CNTF, RCVRN, RAB6A, CLU, CLN3
13	choline32 9 18 9	12.8	CNTF, BDNF, HSPG2, CALB1, GLUD1, NTF3
14	quinolinic acid32 18	10.8	CNTF, BDNF, CALB1, NTF3, NTF4, GFAP
15	glucose32	9.8	CNTF, SERPINF1, PAX6, XBP1, ENO1, CALB1
16	ly29400232	9.7	JUN, CDKN3, FGF2, AIFM1, TIMP3, EP300
17	oxygen32 18	10.6	SERPINF1, CLU, PAX6, BDNF, SAG, JUN
18	arginine32	9.6	PDE2A, CNTF, CLN3, PAX6, ARSH, ENO1
19	phosphoinositide32	9.5	PDE3B, RAB6A, BDNF, SAG, XBP1, JUN
20	cysteine32	9.4	LRAT, RCVRN, SERPINF1, RAB6A, CLU, PANK2
21	cyclic amp32 18	10.3	PDE2A, PDE3B, CNGB1, CNTF, BDNF, SAG
22	superoxide32 18	10.3	PDE2A, PDE3B, CNTF, CLU, ENO1, ENDOG
23	heparan sulfate32 18	10.2	BMP6, ARSH, ARSA, FGF2, HSPG2, EXTL3
24	dopamine32 9 18 9	12.2	PDE3B, CNTF, BMP6, CLU, BDNF, SAG
25	dbc-amp32	9.2	PDE3B, BMP6, BDNF, CREBBP, GFAP, TIMP3
26	acetylcholine32 9 18 9	12.2	CNTF, BMP6, BDNF, CDKN3, HSPG2, CALB1
27	potassium32 9 18 9	11.9	PDE3B, CNGB1, CNTF, RCVRN, SERPINF1, BDNF
28	pd 98,05932	8.9	CNTF, BMP6, BDNF, JUN, FGF2, HSPG2
29	wortmannin32 42	9.9	PDE3B, CNTF, BDNF, JUN, CDKN3, HSPG2
30	polyacrylamide32	8.9	ATXN7, ARSA, GRK1, GLUD1, TUBA1B, DRD4
31	alanine32	8.9	PDE2A, CNTF, BMP6, PAX6, MTTP, SAG
32	kainate32	8.9	CLU, BDNF, JUN, CDKN3, HSPG2, CALB1
33	aspartate32	8.9	BMP6, BDNF, SAG, ARSA, ENO1, GLUD1
34	bromodeoxyuridine32	8.8	CNTF, BMP6, PAX6, BDNF, FGF2, CALB1
35	adenylate32	8.8	PDE3B, CNTF, BDNF, SAG, CDKN3, HSPG2
36	forskolin32 42 9 9	11.8	PDE3B, CNTF, BMP6, BDNF, JUN, HSPG2
37	gaba32 42	9.6	CNTF, BMP6, BDNF, CDKN3, HSPG2, CALB1
38	h2o232	8.6	CNTF, SERPINF1, BMP6, CLU, BDNF, JUN
39	nmda32 42	9.6	BDNF, CDKN3, INADL, FGF2, HSPG2, CALB1
40	calcium32 9 18 9	11.5	PDE2A, PDE3B, CNGB1, CNTF, RCVRN, SERPINF1
41	glutamine32	8.5	RERE, RBP3, BMP6, RAB6A, SAG, ATXN1
42	okadaic acid32 42	9.4	PDE3B, BMP6, SAG, JUN, CDKN3, PTK2B
43	nitric oxide32 9 18 9	11.4	PDE2A, PDE3B, CNTF, RBP3, SERPINF1, BMP6
44	glutamate32	8.2	CNGB1, SERPINF1, BMP6, CLU, CLN3, CDKN3
45	atp32	8.2	LRAT, PDE3B, RAB6A, CLU, CLN3, PANK2
46	vegf32	7.8	CNTF, SERPINF1, BMP6, CLU, BEST1, PAX6
47	retinoic acid32 42 18	9.8	LRAT, CNTF, RCVRN, RBP3, SERPINF1, BMP6
48	phosphatidylinositol32	7.4	PDE3B, CNTF, BMP6, RAB6A, BDNF, JUN
49	serine32	7.0	PDE3B, CNTF, SERPINF1, BMP6, RAB6A, CLU
50	tyrosine32	6.6	PDE3B, CNTF, SERPINF1, BMP6, RAB6A, CLU

Cellular components related to retinal degeneration according to GeneDecks:

(show all 19)

id	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor inner segment	GO:001917	11.1	RHO, RP1, PPEF2, TULP1, AIPL1, GNAT2
2	photoreceptor outer segment	GO:001750	11.0	MYO7A, PROM1, C2orf71, RHO, RP1, RPGR
3	photoreceptor outer segment membrane	GO:042622	10.9	ROM1, PROM1, PRPH, RHO, GNAT2, CDHR1
4	stereocilium	GO:032420	10.7	MYO7A, USH1C, FSCN2, CDH23, PROM1
5	cilium membrane	GO:060170	10.7	PROM2, TMEM67, ARL6, BBS7, BBS4, BBS2
6	BBSome	GO:034464	10.6	ARL6, BBS7, BBS4, BBS2, BBS1
7	cilium axoneme	GO:035085	10.4	NPHP1, TTC21B, RP1, RP1L1, RPGRIP1L, IFT80
8	cilium	GO:005929	10.3	NPHP4, NPHP3, PKD2, PKD1, RP2, RPGRIP1
9	PCAF complex	GO:000125	10.1	TAF12, TADA2A, TAF9, TRRAP
10	centrosome	GO:005813	9.8	EP300, NPHP4, RPGR, RPGRIP1L, PPP4C, TMEM67
11	membrane	GO:016020	9.7	SPHK2, PITPNM1, PDE6B, ABCA4, NPHP1, NPHP4
12	STAGA complex	GO:030914	9.3	TAF12, TAF9, TAF5L, TADA3, SUPT3H, TRRAP
13	transcription factor TFTC complex	GO:033276	9.3	TAF12, TAF9, TAF5L, TADA3, SUPT3H, TRRAP
14	extracellular space	GO:005615	8.4	RS1, COL2A1, NDP, TGFBI, DKK3, PROM1
15	cytoplasm	GO:005737	8.1	CRYAB, RPGRIP1L, RP1L1, RP2, RP1, PKD1
16	nonmotile primary cilium	GO:031513	INF	PKD2, BBS4, RAB8A,
17	microtubule basal body	GO:005932	INF	TMEM67, RPGRIP1L, RPGR, PKD2, NPHP4, IFT80
18	photoreceptor connecting cilium	GO:032391	INF	NPHP1, TOPORS, RP1, RP1L1, CEP290, MYO7A
19	motile cilium	GO:031514	INF	NPHP1, MKKS, BBS4, BBS2,

Biological processes related to retinal degeneration according to GeneDecks:

(show all 36)

id	Name	GO ID	Score	Top Affiliating Genes
1	visual perception	GO:007601	11.5	ABCA4, TIMP3, TGFBI, PRCD, PRPH2, OPN4
2	phototransduction	GO:007602	11.0	TULP1, NR2E3, PITPNM1, OPN4, TUB, GNAT2
3	response to stimulus	GO:050896	11.0	RDH5, RDH8, USH2A, CHM, BBS1, BBS10
4	phototransduction, visible light	GO:007603	11.0	ABCA4, RHO, PDE6C, PDE6B, RP1, AIPL1
5	photoreceptor cell maintenance	GO:045494	11.0	BBS4, CDHR1, CDH23, MKKS, TULP1, RP1L1
6	retinal rod cell development	GO:046548	10.9	BBS4, NRL, RP1, TOPORS
7	nonmotile primary cilium assembly	GO:035058	10.9	MKKS, BBS4, BBS10, BBS1
8	retina homeostasis	GO:001895	10.9	AIPL1, BBS4, BBS10, BBS1
9	sensory perception of light stimulus	GO:050953	10.9	CDH23, USH2A, USH1C, MYO7A
10	pigment granule aggregation in cell center	GO:051877	10.9	BBS4, BBS7, MKKS
11	melanosome transport	GO:032402	10.9	ARL6, MKKS, BBS7, BBS4, BBS2
12	convergent extension involved in gastrulation	GO:060027	10.8	BBS4, MKKS, NPHP3
13	rhodopsin mediated phototransduction	GO:009586	10.8	SAG, GRK1, RHO
14	rhodopsin mediated signaling pathway	GO:016056	10.8	SAG, GRK1, RHO
15	retinal cone cell development	GO:046549	10.7	TOPORS, PDE6C, RP1, GNAT2
16	cilium morphogenesis	GO:060271	10.7	NPHP3, TMEM67, MKKS, CEP290, BBS7, BBS4
17	eye photoreceptor cell development	GO:042462	10.7	RORB, CRB1, TULP1, CEP290, PAX6, MYO7A
18	negative regulation of appetite by leptin-mediated signaling pathway	GO:038108	10.7	MKKS, BBS2, BBS4
19	retina development in camera-type eye	GO:060041	10.7	RHO, PRPH2, NPHP1, NPHP4, PDE6B, TULP1
20	protein kinase C-activating G-protein coupled receptor signaling pathway	GO:007205	10.7	DGKZ, DGKQ, DGKI, DGKE, DGKB, SPHK1
21	determination of left/right symmetry	GO:007368	10.6	NPHP3, PKD2, RPGRIP1L, ARL6, MKKS, BBS7
22	cilium assembly	GO:042384	10.6	RPGR, RPGRIP1L, TMEM67, ARL6, MKKS, CEP290
23	equilibrioception	GO:050957	10.6	MYO7A, USH1C, CDH23
24	regulation of cilium beat frequency involved in ciliary motility	GO:060296	10.5	MKKS, BBS4, BBS2
25	photoreceptor cell outer segment organization	GO:035845	10.5	NPHP1, TOPORS, RP1
26	retina layer formation	GO:010842	10.4	PROM1, TOPORS, RS1, CALB1
27	sphingolipid metabolic process	GO:006665	10.4	ACER2, SMPD3, SPHK1, SPHK2, ARSA, ARSH
28	cell death	GO:008219	10.2	ACO2, SPG11, TBP, ATXN7, ATXN1, CIDEA
29	retinol metabolic process	GO:042572	10.2	RDH8, RDH5, RDH12, LRAT
30	sensory perception of sound	GO:007605	10.2	SLC1A3, NDP, COL2A1, TUB, ALDH7A1, CDH23
31	regulation of retinal cell programmed cell death	GO:046668	10.1	BDNF, FGF2, CNTF
32	mechanoreceptor differentiation	GO:042490	9.9	BDNF, NTF3, NTF4
33	negative regulation of apoptotic process	GO:043066	9.8	EPO, PRKAA1, TAF9, TOPORS, COL2A1, NOC2L
34	histone deubiquitination	GO:016578	9.6	SUPT3H, TRRAP, KAT2A, ATXN7
35	histone H3 acetylation	GO:043966	9.6	TAF12, TADA2A, TAF9, TAF5L, TADA3, SUPT3H
36	transcription from RNA polymerase II promoter	GO:006366	9.3	NRL, TAF5L, TAF9, TADA2A, TAF12, NR2E3

Molecular functions related to retinal degeneration according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	phosphatidylinositol transporter activity	GO:008526	10.7	PITPNC1, PITPNM1, PITPNA, PITPNM3
2	G-protein coupled photoreceptor activity	GO:008020	10.5	OPN4, ELOVL4, TULP1, TUB, GNAT2
3	diacylglycerol kinase activity	GO:004143	10.5	DGKZ, DGKQ, DGKI, DGKE, DGKB, SPHK1
4	calcium sensitive guanylate cyclase activator activity	GO:008048	10.5	GUCA1B, GUCA1A, RCVRN
5	Rab geranylgeranyltransferase activity	GO:004663	10.5	RABGGTB, RABGGTA, CHM
6	protein serine/threonine phosphatase activity	GO:004722	10.1	PPEF1, PPEF2, PPP4C, CDKN3, PPP5C
7	metal ion binding	GO:046872	9.8	RPE65, PITPNM1, PDE6B, PDE6C, RHO, TIMP3
8	growth factor activity	GO:008083	9.2	GDNF, NUDT6, NDP, NRTN, NTF4, NTF3
9	histone acetyltransferase activity	GO:004402	8.7	EP300, TAF12, TADA2A, TAF9, TAF5L, TADA3
10	transcription coactivator activity	GO:003713	8.0	EP300, TAF12, TAF9, TAF5L, TADA3, CREBBP
11	protein binding	GO:005515	5.4	TMEM67, NOC2L, RPGRIP1L, RP1L1, RPGRIP1, RP2