Aliases & Classifications for Retinal Detachment

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Retinal Detachment, Aliases & Descriptions:

Name: Retinal Detachment 9 11 43 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology9 DOID:5327
NCIt38 C26874
MeSH33 D012163
ICD9CM27 361.9
ICD1025 H33.0

Summaries for Retinal Detachment

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MedlinePlus:32 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. it provides the sharp, central vision needed for reading, driving, and seeing fine detail. a retinal detachment lifts or pulls the retina from its normal position. it can occur at any age, but it is more common in people over age 40. it affects men more than women and whites more than african americans. a retinal detachment is also more likely to occur in people who are extremely nearsighted have had a retinal detachment in the other eye have a family history of retinal detachment have had cataract surgery have other eye diseases or disorders have had an eye injury symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. it may also seem like there is a "curtain" over your field of vision. a retinal detachment is a medical emergency. if not promptly treated, it can cause permanent vision loss. if you have any symptoms, see an eye care professional immediately. treatment includes different types of surgery. nih: national eye institute

MalaCards based summary: Retinal Detachment is related to retinoschisis and macular holes, and has symptoms including retinal detachment An important gene associated with Retinal Detachment is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Endochondral Ossification and Renal cell carcinoma. The compounds cystine and alginate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are pigmentation and renal/urinary system.

Wikipedia:63 Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of... more...

Related Diseases for Retinal Detachment

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Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1retinoschisis32.0RS1
2macular holes31.7SERPINF1, TGFB2
3myopia31.0COL2A1, SERPINF1
4exudative vitreoretinopathy 130.9FZD4
5vitreoretinopathy, neovascular inflammatory30.8TGFB2
6uveitis30.7TGFB2, SERPINF1
7blindness30.6RS1, SERPINF1, COL2A1
8melanoma30.1TGFB2, SERPINF1, COL2A1, PDGFB, GAP43
9retinoblastoma29.9GFAP, TGFB2, SERPINF1
10retinal degeneration29.8RS1, GFAP, SERPINF1
11ischemia29.1GFAP, TGFB2, PDGFB, GLUL, GAP43
12retinitis11.5
13choroiditis10.8
14coloboma10.8
15cataract10.7
16cytomegalovirus retinitis10.7
17coats disease10.6
18vitreous detachment10.6
19retinal vein occlusion10.5
20stickler syndrome10.5
21central serous chorioretinopathy10.5
22hellp syndrome10.5
23exudative vitreoretinopathy10.5
24hemangioma10.5
25scleritis10.5
26knobloch syndrome10.5
27endotheliitis10.5
28sympathetic ophthalmia10.4
29chorioretinitis10.4
30weber syndrome10.4
31autosomal dominant rhegmatogenous retinal detachment10.4
32central retinal vein occlusion10.4
33eclampsia10.4
34vogt-koyanagi-harada disease10.4
35ehlers-danlos syndrome classical type10.4
36leukemia10.4
37thrombotic thrombocytopenic purpura10.4
38purpura10.4
39scleral staphyloma10.4
40strabismus10.4
41morning glory syndrome10.4
42ehlers-danlos syndrome, type vi10.3
43donnai-barrow syndrome10.3
44aniridia10.3
45stickler syndrome, type i10.3
46kniest dysplasia10.3
47marfan syndrome10.3
48norrie disease10.3
49sed congenita10.3
50neovascular glaucoma10.3

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to retinal detachment

Symptoms for Retinal Detachment

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HPO human phenotypes related to Retinal Detachment:

id Description Frequency HPO Source Accession
1 retinal detachment HP:0000541

Drugs & Therapeutics for Retinal Detachment

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Drug clinical trials:

Search ClinicalTrials for Retinal Detachment

Search NIH Clinical Center for Retinal Detachment

Genetic Tests for Retinal Detachment

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Anatomical Context for Retinal Detachment

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MalaCards organs/tissues related to Retinal Detachment:

31
Eye, Retina, Brain, Endothelial, Cortex, Kidney, Liver, Breast, Monocytes

Animal Models for Retinal Detachment or affiliated genes

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MGI Mouse Phenotypes related to Retinal Detachment:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9RS1, SERPINF1, FZD4, PDGFB
2MP:00053678.7PDGFB, COL2A1, FZD4, TGFB2
3MP:00053698.0GFAP, TGFB2, FZD4, PDGFB
4MP:00053818.0GFAP, TGFB2, SERPINF1, FZD4, COL2A1
5MP:00053877.7GAP43, PDGFB, COL2A1, TGFB2, GFAP
6MP:00053857.6GFAP, TGFB2, SERPINF1, FZD4, COL2A1, PDGFB
7MP:00053787.1GFAP, TGFB2, FZD4, COL2A1, PDGFB, GLUL
8MP:00107686.9GFAP, TGFB2, FZD4, COL2A1, PDGFB, GLUL
9MP:00053916.7GAP43, RS1, GFAP, TGFB2, SERPINF1, FZD4
10MP:00036316.3RS1, GFAP, TGFB2, SERPINF1, FZD4, COL2A1

Publications for Retinal Detachment

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Articles related to Retinal Detachment:

(show top 50)    (show all 948)
idTitleAuthorsYear
1
Resolution of foveal schisis in X-linked retinoschisis in the setting of retinal detachment. (25892045)
2015
2
Retinal detachment after open globe injury. (24011994)
2014
3
Investigating the pathological processes of rhegmatogenous retinal detachment and proliferative vitreoretinopathy with metabolomics analysis. (24556753)
2014
4
Aniseikonia Following Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment. (25127694)
2014
5
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
6
Surgical repair of macular fold after vitrectomy for bullous rhegmatogenous retinal detachment. (23481455)
2013
7
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
8
Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. (24143072)
2013
9
Flashes, floaters, and oral fluoroquinolones: is retinal detachment a worry? (23307216)
2013
10
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
11
Post-operative hospitalization in retinal detachment correlation to recurrences. (24334776)
2013
12
Dalen Fuch's nodules and serous retinal detachment on optical coherence tomography in sympathetic ophthalmitis. (23760454)
2013
13
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
14
A developmental mechanism of spontaneous reattachment in rhegmatogenous retinal detachment. (22511841)
2012
15
Familial retinal detachment associated with COL2A1 exon 2 and FZD4 mutations. (22574936)
2012
16
Functional and anatomical remodeling in human retinal detachment. (22406310)
2012
17
Persistent submacular fluid diagnosed with optical coherence tomography after successful scleral buckle surgery for macula-off retinal detachment. (22938546)
2012
18
Disappearance of extramacular drusen after chronic retinal detachment. (22557885)
2012
19
The fellow eye in retinal detachment: findings from the Scottish Retinal Detachment Study. (21378003)
2012
20
Longitudinal changes in retinal nerve fiber layer thickness after vitrectomy for rhegmatogenous retinal detachment. (22807292)
2012
21
The incidence of retinal detachment after cataract surgery. (23002414)
2012
22
Six months treatment with ibopamine in patients with hypotony after vitreoretinal surgery for retinal detachment, uveitis or penetrating trauma. (21909052)
2012
23
Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction. (21653215)
2012
24
Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment. (22722489)
2012
25
A chick model of retinal detachment: cone rich and novel. (22970190)
2012
26
Heavy internal tamponade for cases with complicated retinal detachment. (21484628)
2011
27
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
28
Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. (21356360)
2011
29
Trends in primary retinal detachment surgery: results of a Bicenter study. (21242859)
2011
30
Cervicofacial subcutaneous emphysema and pneumomediastinum after retinal detachment surgery: just another monitored anesthesia eye case. (21723109)
2011
31
Contrast-enhanced ultrasonography in the differentiation of retinal detachment and vitreous membrane in dogs and cats. (21967099)
2011
32
Comparison of 20-, 23-, and 25-gauge pars plana vitrectomy in pseudophakic rhegmatogenous retinal detachment repair. (21210580)
2011
33
Visual hallucinations from retinal detachment misdiagnosed as psychosis. (21430493)
2011
34
Apoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescue. (21778775)
2011
35
Cryptococcal-related exudative retinal detachment. (21546919)
2011
36
Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment. (19815730)
2010
37
Outcome of scleral buckling procedures for primary rhegmatogenous retinal detachment. (21381585)
2010
38
Discriminate characteristics of photopsia in posterior vitreous detachment, retinal tears and retinal detachment. (19709374)
2010
39
Pediatric retinal detachment due to Coats' disease diagnosed with bedside emergency department ultrasound. (18226872)
2009
40
Retinal detachment causing unilateral blindness in a 12-year-old girl with gyrate atrophy. (19757146)
2009
41
Combined 5-fluorouracil, low-molecular-weight heparin, and silicone oil in the management of complicated retinal detachment with proliferative vitreoretinopathy grade C. (17674917)
2007
42
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
43
Submacular exudates with serous retinal detachment caused by cat scratch disease. (12778351)
2002
44
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. (11110038)
2000
45
Use of perfluorocarbon liquid in the repair of retinoschisis retinal detachments. (8878197)
1996
46
Retinal detachment with a hiatus hernia. (8012680)
1994
47
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
48
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
49
HEREDITARY RETINOSCHISIS WITH RETINAL DETACHMENT. (14137967)
1964
50
Retinal detachments occurring in cataract associated with neurodermatitis. (14932558)
1952

Variations for Retinal Detachment

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Expression for genes affiliated with Retinal Detachment

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Search GEO for disease gene expression data for Retinal Detachment.

Pathways for genes affiliated with Retinal Detachment

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Compounds for genes affiliated with Retinal Detachment

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Compounds related to Retinal Detachment according to GeneCards Suite gene sharing:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cystine439.8GLUL, PDGFB
2alginate439.7COL2A1, TGFB2
32,3-cyclic nucleotide439.6GFAP, GLUL
4retinaldehyde439.6GLUL, GFAP
5quinolinic acid43 2410.5GFAP, GLUL
6glycosaminoglycan439.5COL2A1, SERPINF1, TGFB2
7nh4cl439.5GLUL, GFAP
8ascorbic acid43 2410.5TGFB2, COL2A1, GLUL
9orthophosphate439.4GAP43, GFAP
10n acetylcysteine439.3GLUL, SERPINF1, TGFB2
11silver439.2GLUL, PDGFB, GFAP
12ribonucleic acid439.2TGFB2, PDGFB, GAP43
13mptp439.1TGFB2, GFAP
14bromodeoxyuridine439.1GFAP, TGFB2, PDGFB
15dbc-amp439.0GAP43, GLUL, GFAP
16streptozotocin439.0GFAP, SERPINF1
17agar439.0GFAP, TGFB2, PDGFB
18polyacrylamide439.0GFAP, GLUL, GAP43
19gaba439.0GFAP, GLUL, GAP43
20matrigel438.9SERPINF1, TGFB2, GFAP
21oligonucleotide438.9TGFB2, COL2A1, PDGFB, GAP43
22arginine438.9GFAP, FZD4, COL2A1, GLUL
23nmda43 289.8GFAP, GLUL, GAP43
24ethanol43 49 24 1211.8GAP43, GLUL, GFAP
256-hydroxydopamine438.7GAP43, GFAP
26aspartate438.7GFAP, COL2A1, GLUL, GAP43
27paraffin438.7GFAP, TGFB2, PDGFB, GLUL
28potassium43 24 1210.7GFAP, TGFB2, SERPINF1
29thymidine43 249.7GFAP, TGFB2, PDGFB, GLUL
30adenylate438.6GAP43, GLUL, FZD4, GFAP
31alanine438.6GAP43, GLUL, COL2A1, GFAP
32dopamine43 28 24 1211.5GFAP, TGFB2, FZD4, GAP43
33methionine438.5GAP43, GLUL, SERPINF1, GFAP
34forskolin43 49 1210.5GAP43, TGFB2, GFAP
35vegf438.5GFAP, TGFB2, SERPINF1, PDGFB
36progesterone43 28 59 24 1212.4GAP43, PDGFB, TGFB2, GFAP
37threonine438.4GFAP, SERPINF1, GLUL, GAP43
38estrogen438.4GFAP, TGFB2, PDGFB, GLUL
39oxygen43 249.4GFAP, SERPINF1, COL2A1, PDGFB, GLUL
40lipid438.2GFAP, COL2A1, PDGFB, GLUL, GAP43
41glucose438.2GFAP, TGFB2, SERPINF1, PDGFB, GLUL
42retinoic acid43 249.1GFAP, TGFB2, SERPINF1, COL2A1, GAP43
43cycloheximide437.8GFAP, TGFB2, COL2A1, PDGFB, GLUL, GAP43
44nitric oxide43 24 129.7TGFB2, SERPINF1, FZD4, COL2A1, PDGFB, GLUL
45cysteine437.7GFAP, TGFB2, SERPINF1, COL2A1, GLUL, GAP43
46glutamate437.6GFAP, TGFB2, SERPINF1, FZD4, GLUL, GAP43
47calcium43 49 24 1210.3GFAP, TGFB2, SERPINF1, FZD4, COL2A1, GLUL
48dexamethasone43 49 28 1210.3GAP43, GFAP, TGFB2, SERPINF1, COL2A1, PDGFB
49serine437.2GFAP, TGFB2, SERPINF1, COL2A1, PDGFB, GLUL
50tyrosine437.2GFAP, TGFB2, SERPINF1, FZD4, PDGFB, GLUL

GO Terms for genes affiliated with Retinal Detachment

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Cellular components related to Retinal Detachment according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.5PDGFB, TGFB2
2extracellular spaceGO:00056158.0PDGFB, COL2A1, SERPINF1, TGFB2, RS1

Biological processes related to Retinal Detachment according to GeneCards Suite gene sharing:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cartilage condensationGO:00015029.9COL2A1, TGFB2
2heart morphogenesisGO:00030079.8COL2A1, TGFB2
3collagen fibril organizationGO:00301999.8TGFB2, COL2A1
4activation of protein kinase activityGO:00321479.7PDGFB, TGFB2
5positive regulation of cell divisionGO:00517819.6PDGFB, TGFB2
6positive regulation of phosphatidylinositol 3-kinase signalingGO:00140689.5TGFB2, PDGFB
7platelet degranulationGO:00025769.5PDGFB, TGFB2
8cell growthGO:00160499.4PDGFB, TGFB2
9hemopoiesisGO:00300979.2PDGFB, TGFB2
10cell proliferationGO:00082839.1GLUL, SERPINF1, TGFB2
11extracellular matrix organizationGO:00301988.6GFAP, TGFB2, COL2A1, PDGFB
12response to woundingGO:00096118.3GAP43, PDGFB, TGFB2, GFAP

Molecular functions related to Retinal Detachment according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:00484079.6PDGFB, COL2A1
2identical protein bindingGO:00428029.3GLUL, PDGFB, COL2A1
3protein heterodimerization activityGO:00469828.8PDGFB, FZD4, TGFB2

Products for genes affiliated with Retinal Detachment

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Sources for Retinal Detachment

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet