MCID: RTN017
MIFTS: 60

Retinal Detachment malady

Eye diseases category

Summaries for Retinal Detachment

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33MedlinePlus, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. it provides the sharp, central vision needed for reading, driving, and seeing fine detail. a retinal detachment lifts or pulls the retina from its normal position. it can occur at any age, but it is more common in people over age 40. it affects men more than women and whites more than african americans. a retinal detachment is also more likely to occur in people who are extremely nearsighted have had a retinal detachment in the other eye have a family history of retinal detachment have had cataract surgery have other eye diseases or disorders have had an eye injury symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. it may also seem like there is a "curtain" over your field of vision. a retinal detachment is a medical emergency. if not promptly treated, it can cause permanent vision loss. if you have any symptoms, see an eye care professional immediately. treatment includes different types of surgery. nih: national eye institute

MalaCards: Retinal Detachment is related to macular holes and proliferative vitreoretinopathy. An important gene associated with Retinal Detachment is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Endochondral Ossification and p70S6K Signaling. The compounds estrogen and matrigel have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are respiratory system and pigmentation.

Wikipedia:63 Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of... more...

Description from OMIM:46 312530

Aliases & Classifications for Retinal Detachment

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

retinal detachment 8 10 44 33 60


External Ids:

Disease Ontology8 DOID:5327
MeSH34 D012163
ICD9CM27 361.9
NCIt39 C26874
OMIM46 312530
ICD1025 H33.0

Related Diseases for Retinal Detachment

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 305)
idRelated DiseaseScoreTop Affiliating Genes
1macular holes31.4HPRT1, SERPINF1, TGFB2
2proliferative vitreoretinopathy31.4TIMP2, TGFB2, GFAP, GLUL, TIMP1
3retinal disease31.0GFAP, GLUL, SERPINF1, RS1, VEGFA, PDGFB
4cataract30.9MMP3, SERPINF1, TGFB2
5diabetic retinopathy30.9TGFB2, SERPINF1, SRF, VEGFA, PDGFB
6proliferative diabetic retinopathy30.9VEGFA, SERPINF1, TIMP1, TGFB2, GFAP, TIMP2
7macular retinal edema30.8VEGFA, SERPINF1
8retinal vein occlusion30.8VEGFA
9glaucoma30.7TIMP2, SERPINF1, TGFB2
10retinal degeneration30.7SERPINF1, RS1, GFAP
11melanoma30.6SRF, COL2A1, TIMP2, SERPINF1, TGFB2, GAP43
12retinopathy of prematurity30.6VEGFA, FZD4
13uveitis30.6SERPINF1, TGFB2
14neovascular glaucoma30.4TGFB2, VEGFA
15pre-eclampsia30.4TIMP2, CBS, SRF, VEGFA
16leukemia30.3SERPINF1, PRG2, PDGFB, HPRT1, SRF, GAP43
17vasculitis30.2PRG2
18retinoblastoma30.2GFAP, SERPINF1, TGFB2, PDGFA
19hemangioblastoma30.2VEGFA, GFAP
20adenocarcinoma30.2TIMP2, TIMP1, PDGFA, PDGFB, VEGFA, SRF
21arthritis30.2TIMP2, TIMP1, HPRT1, MMP3, SRF, COL2A1
22esophagitis29.9PRG2
23meningioma29.9GFAP, GLUL, PDGFB, PDGFA
24tuberculosis29.9PDGFB, GLUL, SRF
25rheumatoid arthritis29.9MMP3, TIMP2, HPRT1, VEGFA, PRG2, TIMP1
26breast cancer29.9TIMP2, TIMP1, MMP3, HPRT1, PDGFA, VEGFA
27age related macular degeneration29.9VEGFA
28squamous cell carcinoma29.9MMP3, KLK11, TGFB2, SERPINF1, PDGFA, SRF
29sarcoidosis29.9PDGFB, TGFB2
30retinitis11.4
31retinoschisis10.8
32vitreous detachment10.8
33choroiditis10.8
34coloboma10.7
35coats disease10.5
36myopia10.5
37cystoid macular edema10.4
38retinal melanoma10.4
39hellp syndrome10.4
40exudative vitreoretinopathy10.4
41scleritis10.4
42stickler syndrome10.4
43chorioretinitis10.4
44thrombotic thrombocytopenic purpura10.4
45central retinal vein occlusion10.4
46coloboma of optic nerve10.4
47sympathetic ophthalmia10.4
48hemangioma10.4
49hypertension10.4
50purpura10.4

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to retinal detachment

Clinical Features for Retinal Detachment

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Sources:
46OMIM
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Clinical features from OMIM:

312530

Drugs & Therapeutics for Retinal Detachment

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Retinal Detachment

Drug clinical trials:

Search ClinicalTrials for Retinal Detachment

Search NIH Clinical Center for Retinal Detachment

Search CenterWatch for Retinal Detachment

Genetic Tests for Retinal Detachment

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Anatomical Context for Retinal Detachment

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32MalaCards
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MalaCards organs/tissues related to Retinal Detachment:

32
Eye, Retina, Brain, Endothelial, Cortex, Kidney, Liver, Breast, Monocytes

Animal Models for Retinal Detachment or affiliated genes

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36MGI
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Publications for Retinal Detachment

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50PubMed
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Articles related to Retinal Detachment:

(show top 50)    (show all 944)
idTitleAuthorsYear
1
Vitrectomy combined with periocular/intravitreal injection of steroids for rhegmatogenous retinal detachment associated with choroidal detachment. (23648998)
2014
2
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
3
Rhegmatogenous retinal detachment following electrical shock injury. (23826543)
2013
4
The incidence of rhegmatogenous retinal detachment in The Netherlands. (23218185)
2013
5
Severe retinopathy of prematurity with retinal detachment in monozygotic twins. (23782366)
2013
6
Aggressive posterior retinopathy of prematurity: risk factors for retinal detachment despite confluent laser photocoagulation. (23022161)
2013
7
Correction: Five Year Nationwide Incidence of Rhegmatogenous Retinal Detachment Requiring Surgery in Korea. (24324566)
2013
8
National survey of progressive symptomatic retinal detachment complicating retinoschisis in the United Kingdom. (24136569)
2013
9
Pars plana vitrectomy to repair retinal detachment following brachytherapy for uveal melanoma. (24064939)
2013
10
Retinal detachment after open-globe injury. (24088935)
2013
11
Oral anticoagulation and the risk of vitreous hemorrhage and retinal tears in eyes with acute posterior vitreous detachment. (23108264)
2013
12
RNFL damage after treatment for retinal detachment. (23883790)
2013
13
Retinal detachment model in rodents by subretinal injection of sodium hyaluronate. (24056325)
2013
14
Alteration of Vitreal Retinoschisin Level in Human Primary Retinal Detachment. (24370778)
2013
15
Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment. (22722489)
2012
16
Prediction of proliferative vitreoretinopathy after retinal detachment surgery: potential of biomarker profiling. (22541653)
2012
17
Retinal vasoproliferative tumor with total retinal detachment managed with plaque radiotherapy. (22557879)
2012
18
Primary 23-gauge vitreoretinal surgery for rhegmatogenous retinal detachment. (22762056)
2012
19
Two-step surgery for retinal detachment caused by myopic macular hole. (23152655)
2012
20
Therapy with Chinese medicine in WaldenstrAPm's macroglobulinemia-associated retinal detachment. (21373983)
2012
21
Disrupted foveal photoreceptors after combined cystoid spaces and retinal detachment in branch vein occlusion treated with bevacizumab. (22481482)
2012
22
Subfoveal choroidal thickness change following segmental scleral buckling for rhegmatogenous retinal detachment. (22939214)
2012
23
1000 cSt silicone oil vs heavy silicone oil as intraocular tamponade in retinal detachment associated to myopic macular hole. (21080197)
2011
24
Systemic bevacizumab (Avastin) for exudative retinal detachment secondary to choroidal melanoma. (21445839)
2011
25
Surgical management of unilateral rhegmatogenous retinal detachment associated with ocular coloboma in a 7-year-old child with Noonan syndrome. (22696753)
2011
26
Sliding macular fold following retinal detachment surgery. (20931216)
2011
27
Acute lymphocytic leukemia relapsing as bilateral serous retinal detachment: a case report. (21720411)
2011
28
Retinal adaptability loss in serous retinal detachment with central serous chorioretinopathy. (20164451)
2010
29
Chronic Retinal Detachment Associated with Central Retinal Artery Occlusion. (20337308)
2010
30
To push? or not to push?: Second stage management in a patient with Stickler syndrome at risk of retinal detachment. (19280503)
2009
31
Pyogenic granuloma after retinal detachment surgery with scleral buckle: case report. (19820798)
2009
32
Lens-sparing vitrectomy effective for reattachment of newly developed falciform retinal detachment in a patient with Norrie disease. (19365046)
2009
33
Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment. (18815803)
2009
34
Combined rhegmatogenous and traction retinal detachment in proliferative diabetic retinopathy: clinical manifestations and surgical outcome. (18347622)
2008
35
Cyclic GMP in the pig vitreous and retina after experimental retinal detachment. (18334939)
2008
36
Retinal detachment: visual acuity and subretinal immunoreactive endothelin-1. (18401297)
2008
37
Scleral buckling with macular plombe for eyes with myopic macular retinoschisis and retinal detachment without macular hole. (16935595)
2006
38
Central serous retinal detachment detected by optical coherence tomography in Leber's idiopathic stellate neuroretinitis. (16365812)
2005
39
Management of branch retinal vein occlusion with vitrectomy and arteriovenous adventitial sheathotomy, the possible role of surgical posterior vitreous detachment. (14685873)
2004
40
Optical coherence tomographic findings of macular holes and retinal detachment after vitrectomy in highly myopic eyes. (12967801)
2003
41
Autosomal dominant rhegmatogenous retinal detachment associated with an Arg453Ter mutation in the COL2A1 gene. (12939326)
2003
42
Serous retinal detachment and cystoid macular edema in hypotony maculopathy. (11239878)
2001
43
Rhegmatogenous retinal detachments with cytomegalovirus retinitis. (10182103)
1998
44
Retinal detachment with a hiatus hernia. (8012680)
1994
45
Bilateral retinal detachment with large breaks of pars plicata associated with coloboma lentis and ocular hypertension. (1635302)
1992
46
Unilateral benign medulloepithelioma associated with bilateral retinal detachment. (1594190)
1992
47
The chemoattractant activity of the vitreous to human scleral fibroblasts following retinal detachment and proliferative vitreoretinopathy. (1540560)
1992
48
Coloboma of the iris and choroid and retinal detachment in oculo-auricular dysplasia (Goldenhar syndrome). (5076735)
1972
49
Retinal detachment associated with coloboma of the choroid. (13789985)
1961
50
Orbital cellulitis with exudative retinal detachment. (13426469)
1957

Genetic Variations for Retinal Detachment

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Expression for genes affiliated with Retinal Detachment

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Detachment

Search GEO for disease gene expression data for Retinal Detachment.

Pathways for genes affiliated with Retinal Detachment

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Sources:
37NCBI BioSystems Database, 51QIAGEN, 4Cell Signaling Technology, 53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Retinal Detachment according to GeneCards/GeneDecks:

(show all 29)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5COL2A1
2
Hide members
10.5PDGFB
3
Hide members
10.4FZD4, PDGFA
4
Hide members
10.4PDGFA, PDGFB
510.4FZD4, PDGFB, PDGFA
610.4TIMP2, TIMP1, TGFB2
710.4VEGFA, PDGFB, TIMP2
8
Hide members
10.4TIMP2, TIMP1, MMP3
9
Hide members
10.4TIMP1, PDGFA, VEGFA
10
Cell adhesion ECM remodeling
Hide members
10.4COL2A1, TIMP2, TIMP1, MMP3
11
Hide members
10.4COL2A1, TIMP2, TIMP1, MMP3
12
Hide members
10.4COL2A1, PDGFA, PDGFB, VEGFA
1310.4PDGFA, PDGFB, VEGFA, TGFB2
14
Hide members
10.4TIMP2, TIMP1, PDGFA, PDGFB
15
Hide members
10.4TIMP2, TIMP1, PDGFA, PDGFB
16
Hide members
10.4PDGFB, PDGFA, TIMP1, TIMP2
17
Hide members
10.4TGFB2, SRF, PDGFB, PDGFA
18
Hide members
10.3SRF, VEGFA, PDGFB, PDGFA
1910.3TGFB2, VEGFA, FZD4, PDGFB, PDGFA
2010.3TGFB2, SRF, FZD4, PDGFB, PDGFA
21
Hide members
10.3TIMP2, TIMP1, PDGFA, PDGFB, TGFB2
22
Hide members
10.3TIMP2, TIMP1, PDGFA, PDGFB, TGFB2
23
Hide members
10.3TIMP1, PDGFA, PDGFB, TGFB2, TIMP2
24
Hide members
10.3TIMP2, TIMP1, PDGFA, PDGFB, FZD4, TGFB2
25
Hide members
10.3TIMP1, PDGFA, PDGFB, VEGFA, SRF, SERPINF1
26
Hide members
10.3TIMP2, TIMP1, PDGFA, PDGFB, MMP3, SRF
27
Hide members
10.3COL2A1, TIMP2, TIMP1, PDGFA, PDGFB, PRG2
28
Hide members
10.3MMP3, KLK11, COL2A1, TIMP2, TIMP1, PDGFA
29
Hide members
10.2COL2A1, TIMP2, TIMP1, PDGFA, PDGFB, FZD4

Compounds for genes affiliated with Retinal Detachment

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Sources:
44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Retinal Detachment according to GeneCards/GeneDecks:

(show top 50)    (show all 114)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9GLUL, GFAP
2matrigel4410.8MMP3, TGFB2
3cycloheximide4410.8COL2A1, PDGFA, PDGFB, GAP43
4procollagen4410.8COL2A1
5alginate4410.8COL2A1
6glutamate4410.8GLUL, KLK11, FZD4, HPRT1, GFAP, SRF
7glycosaminoglycan4410.7TIMP2, TIMP1, MMP3, SRF, TGFB2, COL2A1
8oxygen44 2411.7PRG2, GLUL, GFAP, SERPINF1, PDGFA, TIMP2
9nitric oxide44 11 2412.7PRG2, GLUL, COL2A1, TIMP1, PDGFB, FZD4
10propionate4410.7TIMP2, GFAP, TIMP1, MMP3
11ribonucleic acid4410.7TIMP2, TIMP1, PDGFA, TGFB2, PDGFB, MMP3
12glucose4410.7GFAP, TIMP2, TGFB2, SRF, SERPINF1
13ascorbic acid44 2411.7COL2A1, TIMP2, PDGFA, GLUL, HPRT1, MMP3
14glyceraldehyde 3-phosphate4410.7MMP3, HPRT1, GFAP, TIMP2, TIMP1, GLUL
15paraffin4410.7TIMP2, TIMP1, PDGFA, PDGFB, VEGFA, GLUL
1612-o-tetradecanoylphorbol 13-acetate4410.7PDGFA, GAP43, TIMP1, TIMP2, GLUL, MMP3
17methotrexate44 49 1112.6HPRT1, SRF, MMP3, TIMP1, TIMP2, CBS
18dexamethasone44 49 28 1113.6TGFB2, SERPINF1, SRF, GFAP, GLUL, VEGFA
19n acetylcysteine4410.6VEGFA, GLUL, TGFB2, SERPINF1, MMP3, TIMP1
20heparin44 28 11 2413.6MMP3, SRF, PRG2, TIMP2, SERPINF1, GAP43
21genistein44 28 59 2 11 2415.6TGFB2, SRF, GFAP, MMP3, VEGFA, PRG2
22progesterone44 59 28 11 2414.6GFAP, PDGFB, TIMP2, TIMP1, PDGFA, GAP43
23methionine4410.6GLUL, SERPINF1, GAP43, MMP3, GFAP, CBS
24thymidine44 2411.6SRF, TGFB2, GFAP, HPRT1, GLUL, TIMP2
25nmda44 2811.6GFAP, GAP43, SRF, MMP3, CBS
26oligonucleotide4410.6GAP43, PDGFB, TGFB2, SRF, CBS, PRG2
27serine4410.6CBS, COL2A1, TIMP2, PDGFB, GAP43, SRF
28cholesterol44 28 11 2413.6CBS, TIMP1, GAP43, TIMP2, GLUL, GFAP
29arginine4410.6GLUL, KLK11, COL2A1, TIMP1, FZD4, CBS
30vegf4410.6MMP3, TIMP2, PDGFA, PDGFB, TIMP1, TGFB2
31creatinine4410.6GLUL, SRF, TIMP2, HPRT1, TGFB2, MMP3
32tyrosine4410.6PDGFB, SERPINF1, SRF, GFAP, GLUL, PDGFA
33zinc44 2411.6MMP3, TIMP2, GFAP, PDGFA, COL2A1, SRF
34retinoic acid44 2411.6GAP43, GFAP, PRG2, TIMP1, TIMP2, COL2A1
35tgf beta14410.6MMP3, TIMP1, PDGFA, PDGFB, TGFB2
36lipid4410.6PDGFB, CBS, GAP43, COL2A1, GLUL, GFAP
37adenylate4410.6TIMP2, TIMP1, FZD4, GLUL, HPRT1, GFAP
38cysteine4410.6HPRT1, GLUL, CBS, PRG2, GAP43, GFAP
39latanoprost44 1111.6TIMP1, MMP3, TIMP2
40hyaluronic acid44 2411.6TGFB2, MMP3, VEGFA, TIMP1, TIMP2
41(4-aminophenyl)mercuric acetate4410.5TIMP1, MMP3
42alanine4410.5SRF, TIMP2, COL2A1, TIMP1, GAP43, GLUL
43pd 98,0594410.5MMP3, TIMP2, TIMP1, PDGFA, PDGFB, GFAP
44h2o24410.5TIMP2, GAP43, GLUL, HPRT1, SERPINF1
45calcium44 49 11 2413.5GLUL, MMP3, SRF, TGFB2, GFAP, CBS
46cyclosporin a44 28 5912.4TGFB2, PDGFB, TIMP2, SRF
47dbc-amp4410.4GAP43, GLUL, GFAP, SRF
48vitamin a44 11 2412.3TGFB2, SRF, HPRT1, GAP43, TIMP1
49glutamine4410.2TGFB2, GFAP, HPRT1, GLUL, TIMP1, MMP3
50pge24410.1VEGFA

GO Terms for genes affiliated with Retinal Detachment

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Sources:
16Gene Ontology
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Cellular components related to Retinal Detachment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basement membraneGO:00560410.4TIMP1, TIMP2, COL2A1
2platelet alpha granule lumenGO:03109310.4TGFB2, VEGFA, PDGFB, PDGFA, TIMP1
3extracellular regionGO:00557610.2TIMP1, TIMP2, COL2A1, KLK11, PDGFA, PDGFB
4extracellular spaceGO:00561510.1COL2A1, TIMP2, PDGFA, PDGFB, VEGFA, MMP3
5cell surfaceGO:00998610.0TIMP2, PDGFA, PDGFB, FZD4, VEGFA

Biological processes related to Retinal Detachment according to GeneCards/GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of phosphatidylinositol biosynthetic processGO:01051210.7PDGFB, PDGFA
2positive regulation of protein autophosphorylationGO:03195410.7VEGFA, PDGFB, PDGFA
3response to woundingGO:00961110.7PDGFA, PDGFB, GAP43, GFAP, TGFB2
4activation of protein kinase activityGO:03214710.7PDGFB, VEGFA, TGFB2
5positive regulation of cell divisionGO:05178110.7TGFB2, VEGFA, PDGFB, PDGFA
6platelet degranulationGO:00257610.7TIMP1, PDGFA, PDGFB, VEGFA, TGFB2
7positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathwayGO:03579310.7PDGFB, PDGFA
8extracellular matrix disassemblyGO:02261710.7COL2A1, TIMP2, TIMP1, MMP3
9heart morphogenesisGO:00300710.7TGFB2, VEGFA, COL2A1
10response to hypoxiaGO:00166610.6PDGFA, PDGFB, VEGFA, SRF, TGFB2
11platelet activationGO:03016810.6TIMP1, PDGFA, PDGFB, VEGFA, SRF, TGFB2
12positive regulation of MAP kinase activityGO:04340610.6PDGFA, PDGFB, VEGFA
13positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.6TGFB2, PDGFB, PDGFA
14extracellular matrix organizationGO:03019810.6TGFB2, COL2A1, TIMP2, TIMP1, PDGFA, PDGFB
15response to cytokine stimulusGO:03409710.6SRF, TIMP1, TIMP2
16positive regulation of MAPK cascadeGO:04341010.5PDGFB, PDGFA, TIMP2
17positive regulation of cell proliferationGO:00828410.5TIMP1, PDGFA, PDGFB, VEGFA, TGFB2
18cartilage development involved in endochondral bone morphogenesisGO:06035110.5COL2A1, CBS
19blood coagulationGO:00759610.4TIMP1, PDGFA, PDGFB, VEGFA, TGFB2
20cell projection assemblyGO:03003110.4PDGFA, PDGFB
21cell migration involved in sprouting angiogenesisGO:00204210.4SRF, VEGFA
22negative regulation of platelet activationGO:01054410.3PDGFB, PDGFA
23response to drugGO:04249310.1TIMP2, PDGFA, PDGFB, TGFB2

Molecular functions related to Retinal Detachment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:04840710.5PDGFB, PDGFA, COL2A1
2metalloendopeptidase inhibitor activityGO:00819110.4TIMP1, TIMP2
3platelet-derived growth factor receptor bindingGO:00516110.4PDGFA, PDGFB, VEGFA
4protein homodimerization activityGO:04280310.4TGFB2, PDGFA, PDGFB, FZD4, VEGFA, CBS
5protein heterodimerization activityGO:04698210.2TGFB2, VEGFA, FZD4, PDGFB, PDGFA
6growth factor activityGO:00808310.1PDGFA, PDGFB, VEGFA, TGFB2

Products for genes affiliated with Retinal Detachment

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  • Antibodies
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Sources for Retinal Detachment

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet