Retinal Detachment malady

Wikipedia: Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of...⁴⁴ more...

MalaCards: Retinal Detachment is related to knobloch syndrome and proliferative vitreoretinopathy. An important gene associated with Retinal Detachment is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Glioma Invasiveness and Actin-Based Motility by Rho Family GTPases. The compounds glycosaminoglycan and ascorbic acid have been mentioned in the context of this disorder. Affiliated tissues include retina, monocytes and t cells, and related mouse phenotypes are respiratory system and embryogenesis.

Aliases & Descriptions:

retinal detachment 6 8 32 43

Diseases related to retinal detachment by text searches and GeneDecks gene sharing:

(show top 50)    (show all 816)

id	Related Disease	Score	Top Affiliating Genes
1	knobloch syndrome	32.7	COL18A1, ADAMTS18
2	proliferative vitreoretinopathy	31.5	FN1, FGF2, CCL2, GLUL, CTGF, GFAP
3	stickler syndrome	30.0	COL9A2, COL11A1, COL2A1, COL9A1
4	exudative vitreoretinopathy	29.8	LRP5, FZD4, IKBKG, NDP, TSPAN12
5	coats disease	29.7	VEGFA, FZD4, ENO2, IKBKG, RS1, NDP
6	ehlers-danlos syndrome	29.5	FN1, LOX, PLOD1, COL2A1, ELN
7	weber syndrome	29.3	VEGFA, FN1, SST
8	central retinal vein occlusion	28.8	VEGFA, IL6, PLAT
9	retinal disease	28.4	VEGFA, FGF2, IGF1, RS1, RHO, NDP
10	atopic dermatitis	28.2	CCL2, IFNG, TNF, RNASE3, TIMP1, PRG2
11	retinal vein occlusion	26.9	SERPINF1, VEGFA, LEP, IL6, CCL2, CBS
12	vitreoretinopathy	25.8	LRP5, SERPINF1, VIM, VEGFA, FZD4, MMP3
13	uveitis	25.4	SERPINF1, VEGFA, MMP3, IL6, CCL2, IFNG
14	retinopathy of prematurity	24.8	SERPINF1, VEGFA, FZD4, FGF2, IL6, IKBKG
15	vasculitis	23.4	VEGFA, FN1, FGF2, IL6, CCL2, IFNG
16	proliferative diabetic retinopathy	23.1	SERPINF1, VEGFA, FGF2, IL6, CCL2, IGF1
17	dermatitis	22.2	VIM, VEGFA, LEP, MMP3, IL6, ENO2
18	cataract	21.6	SERPINF1, VIM, VEGFA, KCNJ13, LEP, LEPREL1
19	homocysteine	21.4	VEGFA, LEP, IL6, CCL2, IGF1, LOX
20	diabetic retinopathy	21.2	SERPINF1, VIM, VEGFA, LEP, FN1, FGF2
21	retinitis	21.1	LRP5, SERPINF1, VIM, VEGFA, RAB11FIP4, KCNJ13
22	neuronitis	16.3	SERPINF1, VIM, VEGFA, KCNJ13, LEP, FZD4
23	microcystic meningioma	13.9	VEGFA, TIMP1, TIMP2
24	snowflake vitreoretinal degeneration	13.9	KCNJ13, COL11A1, COL2A1
25	vitreous syneresis	13.8	COL11A1, COL2A1, PRG2
26	osteoporosis-pseudoglioma syndrome	13.8	LRP5, FZD4, NDP
27	sorsby fundus dystrophy	13.8	MMP3, ELN, TIMP1
28	retinal vascular disease	13.8	SERPINF1, VEGFA, CTGF, NDP
29	pierre robin sequence	13.8	COL9A2, COL11A1, COL2A1, COL9A1
30	macular retinal edema	13.8	SERPINF1, VEGFA, CXCL12
31	chorioretinal atrophy	13.8	SERPINF1, COL11A1, COL2A1
32	macroglossia	13.7	COL11A1, COL2A1, COL9A1
33	epiphyseal dysplasia	13.7	COL9A2, COL11A1, COL2A1, COL9A1
34	multiple epiphyseal dysplasia	13.7	COL9A2, COL11A1, COL2A1, COL9A1
35	eosinophilic gastroenteritis	13.7	SRF, RNASE3, PRG2
36	osteochondritis dissecans	13.7	MMP3, COL9A2, COL9A1
37	refractive error	13.7	MMP3, RHO, TIMP1, TIMP2
38	neovascular glaucoma	13.6	VEGFA, TGFB2
39	strabismus	13.6	RS1, COL11A1, COL2A1, COL9A1
40	chorioretinitis	13.6	SERPINF1, COL11A1, COL2A1, COL9A1, RHO
41	familial exudative vitreoretinopathy, autosomal dominant	13.6	LRP5, FZD4
42	pineocytoma	13.6	ENO2, RHO, GFAP
43	avascular necrosis of femoral head	13.6	VEGFA, COL2A1, SOD1
44	norrie disease	13.6	LRP5, NDP
45	abdominal aortic aneurysm	13.6	MMP3, CCL2, ELN, TIMP1, TIMP2
46	gingival hypertrophy	13.6	VIM, MMP3, TIMP2
47	cerebral neuroblastoma	13.5	ENO2, GFAP
48	corneal disease	13.5	TIMP1, TGFB2, TGFBI
49	lacrimal duct obstruction	13.5	MMP3, RNASE3, PDGFA, ELN, TGFB2
50	bednar's tumor	13.5	VIM, ENO2, PDGFB

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to retinal detachment:

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MGI Mouse Phenotypes related to retinal detachment:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	PRG2, ELN, PDGFB, COL2A1, CTSA, SRF
2	embryogenesis phenotype	MP:0005380	9.9	TGFB2, COL2A1, CBS, FKTN, FZD4, MTERFD1
3	craniofacial phenotype	MP:0005382	9.9	EDN1, COL2A1, COL11A1, CTSA, HPRT1, CBS
4	renal/urinary system phenotype	MP:0005367	9.7	NPPA, TGFB2, PDGFB, PDGFA, COL2A1, COL18A1
5	no phenotypic analysis	MP:0003012	9.5	NDP, RHO, PDGFB, PLOD1, SRF, SST
6	endocrine/exocrine gland phenotype	MP:0005379	9.4	HPRT1, IFNG, FZD4, LRP5
7	hematopoietic system phenotype	MP:0005397	9.4	EPO, HGF, PRG2, TGFBI, PDGFB, CTSA
8	pigmentation phenotype	MP:0001186	9.3	RS1, PDGFB, RHO, NDP, RLBP1, HPRT1
9	limbs/digits/tail phenotype	MP:0005371	8.8	COL11A1, COL2A1, COL9A1, TGFB2, CTGF, CBS
10	integument phenotype	MP:0010771	8.7	CTSA, PLOD1, EGF, RLBP1, HPRT1, CBS
11	liver/biliary system phenotype	MP:0005370	8.4	EPO, SOD1, COL2A1, CTSA, HPRT1, CBS
12	nervous system phenotype	MP:0003631	8.3	GAP43, SLC6A6, CXCL12, TGFB2, TGFB1, TIMP2
13	hearing/vestibular/ear phenotype	MP:0005377	8.2	COL9A1, NDP, EDN1, TSPAN12, TGFB2, SOD1
14	skeleton phenotype	MP:0005390	7.8	PLAT, COL2A1, COL9A1, PDGFA, NDP, TGFB2
15	normal phenotype	MP:0002873	7.3	SST, SRF, CTGF, COL2A1, GFAP, IFNG
16	growth/size phenotype	MP:0005378	7.2	GAP43, HGF, CBS, IKBKG, IL6, FKTN
17	immune system phenotype	MP:0005387	7.0	CTSA, SRF, TNF, HPRT1, CBS, IFNG
18	behavior/neurological phenotype	MP:0005386	6.6	CTSA, SRF, SST, HMGB1, PLAT, PLOD1
19	mortality/aging	MP:0010768	6.6	GFAP, EDN1, COL2A1, COL11A1, NOS2, PLOD1
20	reproductive system phenotype	MP:0005389	6.2	TNF, NOS2, PDGFA, PDGFB, NDP, TIMP1
21	tumorigenesis	MP:0002006	5.7	TNF, NOS2, COL18A1, TIMP1, TGFB1, TGFBI
22	digestive/alimentary phenotype	MP:0005381	5.5	CTGF, PLAT, NOS2, COL11A1, COL2A1, EDN1
23	vision/eye phenotype	MP:0005391	4.4	IFNG, CCL2, IL6, FGF2, JMJD6, FZD4
24	homeostasis/metabolism phenotype	MP:0005376	4.1	HMGB1, LRP5, VIM, VEGFA, LEP, HPRT1
25	muscle phenotype	MP:0005369	4.0	PDGFB, PDGFA, NOS2, PLOD1, PLAT, SRF
26	cellular phenotype	MP:0005384	3.1	RHO, NOS2, PLAT, CTSA, CTGF, SRF
27	cardiovascular system phenotype	MP:0005385	2.2	EPO, HGF, SLC6A6, NPPA, SOD1, CXCL12

Articles related to retinal detachment:

(show all 42)

id	Title	Authors	Year	Affiliating Genes
1	Stromal cell-derived factor-1 is essential for photor eceptor cell protection in retinal detachment. (20889568)	Otsuka H.... Sakamoto T.	2010	CXCL12
2	Homocysteine levels in the vitreous of proliferative diabetic retinopathy and rhegmatogenous retinal detachment: its modulating role on lysyl oxidase. (19369240)	Coral K.... Rupak R.	2009	ELN, LOX
3	The effects of transient retinal detachment on cavity size and glial and neural remodeling in a mouse model of X-linked retinoschisi s. (19387072)	Luna G.... Fisher S.K.	2009	RS1
4	Elevated erythropoietin in vitreous of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. (19602911)	Wang Z.Y.... Qu J.	2009	EPO
5	Intraocular expression and release of high-mobility group box 1 protein in retinal detachment. (19139725)	Arimura N.... Maruyama I.	2009	HMGB1
6	Upregulation of Semaphorin 3A and the associated biochemical and cellular events in a rat model of retinal detachment. (18815803)	Klebanov O.... Solomon A.S.	2009	GFAP, GAP43
7	Resolution of persistent exudative retinal detachment in a case of Sturge-Weber syndrome with anti-VEGF administration. (19657986)	Paulus Y.M.... Moshfeghi D.M.	2009	VEGFA
8	Cyclic GMP in the pig vitreous and retina after experimental retinal detachment. (18334939)	Diederen R.M.... Hendrikse F.	2008	NPPA
9	Lysyl oxidase activity in the ocular tissues and the role of LOX in proliferative diabetic retinopathy and rhegmatogenous retinal detachment. (18566459)	Coral K.... Krishnakumar S.	2008	LOX
10	Interleukin-6 as a photoreceptor neuroprotectant in an experimental model of retinal detachment. (18378582)	Chong D.Y.... Zacks D.N.	2008	IL6
11	Retinal detachment: visual acuity and subretinal immunoreactive endothelin-1. (18401297)	Roldan-Pallares M.... Fernandez-Durango R.	2008	EDN1
12	Treatment of total exudative retinal detachment due t o central retinal vein occlusion by intravitreal bevacizumab in a patient with p-ANCA vasculitis. (19668494)	Ferencz J.R.... Korzets Z.	2007	VEGFA
13	Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis. (17284607)	Nakazawa T.... Miller J.W.	2007	CCL2
14	Expression of matrix metalloproteinases in the subretinal fluid correlates with the extent of rhegmatogenous retinal detachment. (16941143)	Symeonidis C.... Dimitrakos S.A.	2007	TIMP1
15	Correlation of the extent and duration of rhegmatogenous retinal detachment with the expression of matrix metalloproteinases in the vitreous. (18046238)	Symeonidis C.... Karakiulakis G.	2007	TIMP1
16	Detection of PEDF in subretinal fluid of retinal detachment: possible role in the prevention of subretinal neovascularization. preliminary results. (16679806)	Abdiu O.... Van Setten G.	2006	SERPINF1
17	Increased nitric oxide (NO) pathway metabolites in th e vitreous fluid of patients with rhegmatogenous retinal detachment or diabetic traction retinal detachment. (16267670)	Diederen R.M.... Hendrikse F.	2006	NOS2
18	Glial cell reactivity in a porcine model of retinal detachment. (16639028)	Iandiev I.... Uhlmann S.	2006	VIM
19	Cytokine gene polymorphisms in retinal detachment patients with and without proliferative vitreoretinopathy: a preliminary study. (16704689)	Sanabria Ruiz-Colmenares M.R.... Yugueros Fernandez M.I.	2006	TGFB1, IL6, IFNG
20	Detection of connective tissue growth factor in subretinal Fluid following retinal detachment: possible contribution to subretinal scar formation, preliminary results. (16118511)	Van Setten G.... Schultz G.	2005	CTGF
21	A novel mutation of COL2A1 resulting in dominantly inherited rhegmatogenous retinal detachment. (15671297)	Richards A.J.... Snead M.P.	2005	COL2A1, COL11A1
22	The efficacy of delayed oxygen therapy in the treatme nt of experimental retinal detachment. (15183794)	Lewis G.P.... Fisher S.K.	2004	GFAP
23	High TGF-beta2 levels during primary retinal detachment may protect against proliferative vitreoretinopathy. (15505063)	DieudonnAc S.C.... Hendrikse F.	2004	HGF, TGFB2
24	Autosomal dominant rhegmatogenous retinal detachment associated with an Arg453Ter mutation in the COL2A1 gene. (12939326)	Go S.L.... Hoyng C.B.	2003	COL2A1
25	Intraocular expression of endostatin reduces VEGF-ind uced retinal vascular permeability, neovascularization, and retinal detachment. (12670875)	Takahashi K.... Campochiaro P.A.	2003	VEGFA
26	A case of Kniest dysplasia with retinal detachment and the mutation analysis. (14644246)	Yokoyama T.... Murakami A.	2003	COL2A1
27	Basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in vitreous fluid from eyes with retinal detachment complicated by proliferative vitreoretinopathy. (12208248)	La Heij E.C.... Hendrikse F.	2002	FGF2, GLUL
28	Levels of basic fibroblast growth factor, glutamine synthetase, and interleukin-6 in subretinal fluid from patients with retinal detachment. (11589877)	La Heij E.C.... Hendrikse F.	2001	GLUL
29	Neuron specific enolase in retinal detachment. (11910528)	Dunker S.... Sebag J.	2001	ENO2
30	Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. (11110038)	Su C.Y.... Wu W.C.	2000	VEGFA
31	Elevation of vitreous leptin in diabetic retinopathy and retinal detachment. (11006255)	Gariano R.F.... Sierra-Honigmann M.R.	2000	LEP
32	Photoreceptor-specific expression of platelet-derived growth factor-B results in traction retinal detachment. (10980138)	Seo M.S.... Campochiaro P.A.	2000	PDGFB, PDGFA
33	Activities of trypsin-like serine proteases and their inhibitors in blood and subretinal fluid of patients with different stages of proliferative vitreoretinopathy in rhegmatogenous retinal detachment (10741259)	Katsnel'son L.A.... Antelava N.D.	2000	KLK11
34	Aqueous levels of eosinophil cationic protein and major basic protein in patients with retinal detachment associated with atopic dermatitis (9558841)	Matsuda H.... Inoue M.	1998	PRG2, RNASE3
35	Vitreous intercellular adhesion molecule 1 in uveitis complicated by retinal detachment. (9640197)	Webster L.... Limb G.A.	1998	TNF
36	Measurements of serum and subretinal fluid before and after surgery of retinal detachment (10436998)	Jin S.... Jiang G.	1997	EGF
37	Retinal detachment in Ehlers-Danlos syndrome. Treatment by pars plana vitrectomy (9410229)	Bodanowitz S.... Kroll P.	1997	PLOD1
38	Activity of cathepsin a in subretinal fluid in primary retinal detachment (9379666)	Obuchowska I.... Proniewska-Skretek E.	1997	CTSA
39	Concentration of vascular endothelial growth factor within the subretinal space and vitreous fluid in rhegmatogenous retinal detach ment (9209137)	Moromizato Y.... Oshima K.	1997	VEGFA
40	Evaluation of antiproliferative effects of the somato statin analogue somatuline in a rabbit model of traction retinal detachment. (8566935)	Baudouin C.... Gastaud P.	1995	IGF1, SST
41	Inhibition of preretinal proliferation by free radical scavengers in an experimental model of tractional retinal detachment. (7698262)	Baudouin C.... Lapalus P.	1994	SOD1
42	Mutation in type II procollagen (COL2A1) that substitutes aspartate for glycine alpha 1-67 and that causes cataracts and retinal detachment: evidence for molecular heterogeneity in the Wagner syndrome and the Stickler syndrome (arthro-ophthalmopathy). (8317498)	Koerkkoe J.... Ala-Kokko L.	1993	COL2A1

Genes related to retinal detachment according to GeneCards:

(show top 50)    (show all 67)

id	Symbol	Description	Score	GeneCards Section Context
1	COL2A1	collagen, type II, alpha 1	11.0	Publications
2	RS1	retinoschisin 1	11.0	Publications
3	FZD4	frizzled family receptor 4	11.0
4	GLUL	glutamate-ammonia ligase	11.0	Publications
5	PDGFB	platelet-derived growth factor beta polypeptide	11.0	Publications
6	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1	11.0	Publications
7	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0
8	GAP43	growth associated protein 43	11.0	Publications
9	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
10	GFAP	glial fibrillary acidic protein	11.0	Publications
11	CBS	cystathionine-beta-synthase	11.0
12	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
13	TGFB2	transforming growth factor, beta 2	11.0	Publications
14	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0
15	TIMP2	TIMP metallopeptidase inhibitor 2	11.0
16	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.0
17	VEGFA	vascular endothelial growth factor A	11.0	Publications
18	KCNJ13	potassium inwardly-rectifying channel, subfamily J, member 13	11.0
19	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
20	NDP	Norrie disease (pseudoglioma)	11.0
21	ADAMTSL4	ADAMTS-like 4	11.0
22	COL9A2	collagen, type IX, alpha 2	11.0
23	CTSA	cathepsin A	11.0	Publications
24	JMJD6	jumonji domain containing 6	11.0
25	MTERFD1	MTERF domain containing 1	11.0	Disorders
26	KLK11	kallikrein-related peptidase 11	11.0	Publications
27	TSPAN12	tetraspanin 12	11.0
28	RLBP1	retinaldehyde binding protein 1	11.0
29	PLOD1	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	11.0	Publications
30	LOX	lysyl oxidase	11.0	Publications
31	COL9A1	collagen, type IX, alpha 1	11.0
32	FKTN	fukutin	11.0
33	TGFBI	transforming growth factor, beta-induced, 68kDa	11.0
34	LRP5	low density lipoprotein receptor-related protein 5	11.0
35	SLC6A6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	11.0
36	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
37	RAB11FIP4	RAB11 family interacting protein 4 (class II)	11.0
38	LEPREL1	leprecan-like 1	11.0
39	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
40	HMGB1	high mobility group box 1	11.0	Publications
41	CTGF	connective tissue growth factor	11.0	Publications
42	COL18A1	collagen, type XVIII, alpha 1	11.0
43	COL11A1	collagen, type XI, alpha 1	11.0	Publications
44	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	11.0
45	ADAMTS18	ADAM metallopeptidase with thrombospondin type 1 motif, 18	11.0
46	RHO	rhodopsin	11.0
47	ELN	elastin	11.0	Publications
48	EDN1	endothelin 1	11.0	Publications
49	SOD1	superoxide dismutase 1, soluble	11.0	Publications
50	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications

Pathways related to retinal detachment according to GeneDecks:

(show top 50)    (show all 109)

id	Pathway	Score	Top Affiliating Genes
1	Glioma Invasiveness36	10.1	FGF2, PDGFA, PDGFB, TGFB2, HGF, TIMP1
2	Actin-Based Motility by Rho Family GTPases36	10.0	CTGF, IGF1
3	CREB Pathway36	9.8	TGFB2, IGF1
4	Inhibition of Angiogenesis by TSP136	9.4	COL9A1, COL18A1, COL9A2, ELN, TGFB2, FN1
5	ERK5 Signaling36	9.1	TGFB2, IL6, CTGF, PDGFA, CXCL12, PDGFB
6	Telomerase Components in Cell Signaling36	9.1	CTGF, HGF, CXCL12, TIMP2, TIMP1, PDGFB
7	Ras Pathway36	9.0	TIMP1, FGF2, CTGF, PDGFA, PDGFB, EGF
8	eNOS Signaling36	8.8	PDGFA, PDGFB, CXCL12, TIMP2, TIMP1, TGFB1
9	Paxillin Interactions36	8.8	EGF, CXCL12, TGFB2, TIMP2, FGF2, IGF1
10	14-3-3 Induced Intracellular Signaling36	8.7	IGF1, TNF, CTGF, PDGFB, TIMP1, TGFB1
11	JNK Pathway36	8.6	EGF, CXCL12, TGFB1, PDGFB, FGF2, IL6
12	PPAR Pathway36	8.6	TGFB2, CTGF, FGF2, IL6, IGF1, TNF
13	PTEN Pathway36	8.6	FN1, HGF, FGF2, CTGF, COL9A2, COL18A1
14	Akt Signaling36	8.5	IL6, CXCL12, TGFB2, HGF, PDGFB, PDGFA
15	Pathways in cancer20	8.4	HGF, VEGFA, PDGFA, TGFB1, EGF, FZD4
16	eIF2 Pathway36	8.2	EGF, PDGFA, IGF1, CTGF, IL6, FGF2
17	IP3 Pathway36	8.0	HGF, PDGFA, IGF1, CTGF, FGF2, PDGFB
18	ERK Signaling36	7.9	SRF, TIMP2, TGFB1, TGFB2, PRG2, CXCL12
19	GSK3 Signaling36	7.8	TGFB2, CXCL12, HGF, TIMP2, TIMP1, EGF
20	Renin-Angiotensin Pathway36	7.7	IL6, IKBKG, IGF1, CTGF, PDGFA, PDGFB
21	p53 Mediated Apoptosis36	7.7	IGF1, IL6, FGF2, CTGF, PDGFA, CXCL12
22	Mitochondrial Apoptosis36	7.7	FGF2, IL6, IGF1, CTGF, PDGFA, EGF
23	mTOR Pathway36	7.7	TIMP2, FGF2, IL6, IGF1, CTGF, PDGFA
24	DHA Signaling36	7.6	PDGFA, TGFB1, TIMP2, TIMP1, FGF2, EGF
25	Nanog in Mammalian ESC Pluripotency36	7.6	HGF, IL6, PDGFA, FZD4, FGF2, IGF1
26	Nuclear Receptor Activation by Vitamin-A36	7.6	PDGFB, FGF2, IL6, IGF1, CTGF, EGF
27	ILK Signaling36	7.6	EGF, PDGFB, PDGFA, COL9A1, COL2A1, COL11A1
28	Rac1 Pathway36	7.6	FGF2, IL6, IGF1, CTGF, PDGFA, PDGFB
29	Pancreatic Adenocarcinoma36	7.6	MMP3, FGF2, CTGF, IGF1, CXCL12, TGFB2
30	p70S6K Signaling36	7.6	HGF, CXCL12, TGFB2, TGFB1, TIMP1, TIMP2
31	Activation of PKC through GPCR36	7.5	IGF1, CTGF, PDGFB, EGF, TIMP1, HGF
32	GPCR Pathway36	7.5	EGF, TIMP1, TIMP2, TGFB1, TGFB2, CXCL12
33	NFAT in Immune Response36	7.4	FGF2, IL6, HGF, IKBKG, CTGF, PDGFA
34	TGF-Beta Pathway36	7.4	TIMP2, TGFB1, PDGFA, CTGF, IGF1, CCL2
35	Rap1 Pathway36	7.4	CTGF, IGF1, IL6, FGF2, PDGFA, PDGFB
36	Estrogen Pathway36	7.4	HGF, CXCL12, TGFB2, TGFB1, PDGFB, TIMP1
37	Molecular Mechanisms of Cancer36	7.2	CXCL12, PRG2, TGFB2, TGFB1, TIMP2, TIMP1
38	Apoptotic Pathways in Synovial Fibroblasts36	7.2	FGF2, IL6, IGF1, HGF, CXCL12, TGFB2
39	PAK Pathway36	7.2	CCL2, IL6, FGF2, IGF1, TNF, HGF
40	NF-KappaB (p50-p65) Pathway36	7.0	TGFB2, CXCL12, HGF, TGFB1, FGF2, IL6
41	NF-KappaB Family Pathway36	7.0	FGF2, IL6, IKBKG, IGF1, TNF, CTGF
42	Cellular Apoptosis Pathway36	7.0	IGF1, HGF, CXCL12, TGFB2, TGFB1, TIMP2
43	Rho Family GTPases36	7.0	TGFB2, TGFB1, TIMP2, TIMP1, GFAP, ELN
44	Tec Kinases Signaling36	6.8	FGF2, IL6, CCL2, IGF1, TNF, PDGFA
45	MAPK Family Pathway36	6.8	FGF2, TIMP1, IKBKG, IGF1, CTGF, PDGFA
46	Antioxidant Action of Vitamin-C36	6.7	CCL2, HGF, IKBKG, TGFB2, TGFB1, TIMP2
47	Cytokine-cytokine receptor interaction20	6.6	LEP, VEGFA, CCL2, IFNG, TNF, PDGFA
48	Phospholipase-C Pathway36	6.6	COL9A2, COL18A1, COL11A1, COL2A1, COL9A1, PDGFA
49	JAK-STAT Pathway36	6.4	EGF, TGFB1, TGFB2, TIMP2, TIMP1, PDGFB
50	MAPK Signaling36	6.1	TIMP2, TIMP1, ELN, EGF, PDGFB, PDGFA

Compounds related to retinal detachment according to GeneDecks:

(show top 50)    (show all 290)

id	Compound	Score	Top Affiliating Genes
1	glycosaminoglycan32	10.1	CXCL12, SRF, LOX, FGF2, COL2A1
2	ascorbic acid32 18	11.0	EPO, TGFB2, TIMP2, PDGFA, COL2A1, PLOD1
3	n acetylcysteine32	9.9	HGF, TIMP1, ELN, RNASE3, CTGF, LOX
4	h2o232	9.9	GLUL, GAP43, ELN, LEP, LOX, CBS
5	bleomycin32 9 9	11.4	PDGFB, PLOD1, CTGF, HPRT1, IGF1, CCL2
6	hyaluronic acid32 18	10.4	TIMP2, ELN, RNASE3, FGF2, FN1, MMP3
7	oxygen32 18	10.0	PDGFB, PDGFA, COL2A1, NOS2, PLOD1, CTGF
8	pge232	8.9	FGF2, FN1, MMP3, LOX, SST, EDN1
9	vitamin a32 9 18 9	11.9	SRF, HPRT1, RHO, ELN, LEP, TGFB2
10	procollagen32	8.7	TGFB1, VIM, MMP3, TIMP1, ELN, PDGFB
11	histamine32 18	9.7	VIM, CCL2, SST, SRF, HGF, PRG2
12	alginate32	8.5	HGF, TGFB2, TGFB1, TIMP1, ELN, COL2A1
13	testosterone32 9 18 9	11.2	SRF, PLOD1, EGF, ELN, GFAP, EPO
14	tgf beta132	8.2	MMP3, FN1, TIMP1, ELN, EGF, PDGFA
15	heparin32 9 18 9	11.2	GAP43, HGF, CXCL12, PRG2, TIMP2, TIMP1
16	arginine32	8.1	PRG2, TGFBI, TIMP1, GFAP, ELN, EDN1
17	glutamate32	8.1	TGFB2, CBS, MMP3, FZD4, LEP, VIM
18	ang ii32	8.0	NPPA, TGFB1, ELN, EGF, EDN1, NOS2
19	matrigel32	7.9	VEGFA, MMP3, FN1, HGF, CXCL12, TGFB2
20	nitric oxide32 9 18 9	10.8	GAP43, SLC6A6, PRG2, TGFB2, TIMP2, TIMP1
21	cyclosporin a32 42	8.8	TGFB1, TIMP2, TIMP1, EDN1, PDGFB, RNASE3
22	methotrexate32 34 42 9 9	11.7	LEP, TIMP2, HGF, TGFB1, TIMP1, TNF
23	losartan32 34 9 9	10.6	ELN, EDN1, PDGFA, PLAT, CTGF, IGF1
24	ly29400232	7.6	CTGF, NOS2, TIMP1, TIMP2, TGFB1, TNF
25	estrogen32	7.6	TGFB2, HMGB1, GLUL, LOX, IGF1, MMP3
26	cysteine32	7.5	SERPINF1, FN1, NDP, RHO, COL2A1, PLAT
27	cytochalasin d32 42	8.5	FGF2, EGF, CTGF, CXCL12, IGF1, TIMP1
28	adenylate32	7.3	PLAT, SST, HPRT1, GLUL, LOX, ENO2
29	paraffin32	7.3	LOX, VIM, VEGFA, LEP, FN1, FGF2
30	glutamine32	7.2	RLBP1, TGFBI, TGFB2, TGFB1, TIMP1, GFAP
31	vitamin d32	7.2	FN1, TGFB2, LRP5, IGF1, MMP3, CCL2
32	creatinine32	7.1	HPRT1, GLUL, IGF1, CCL2, ENO2, FN1
33	prostacyclin32	7.0	LEP, VEGFA, RHO, PDGFB, NOS2, PLAT
34	lactate32	6.8	TIMP2, IL6, FN1, MMP3, VIM, ENO2
35	butyrate32	6.7	EPO, EGF, TGFB1, FN1, GLUL, MMP3
36	lipid32	6.6	RNASE3, COL2A1, CTGF, SRF, TNF, HMGB1
37	herbimycin a32 42	7.6	NOS2, HGF, CXCL12, TIMP2, TIMP1, EGF
38	hydrocortisone32 9 9	8.5	EPO, HGF, TGFB2, ELN, EGF, SST
39	sb 20358032 42	7.5	HGF, CXCL12, TIMP2, TIMP1, VIM, VEGFA
40	vegf32	6.2	MMP3, SERPINF1, EPO, TIMP2, TGFB1, TGFB2
41	tyrosine32	6.2	GAP43, PDGFA, RNASE3, CTGF, SRF, GLUL
42	pd 98,05932	5.8	PDGFA, LEP, MMP3, CTGF, TNF, HMGB1
43	indomethacin32 9 9	7.3	PRG2, IL6, FN1, MMP3, LEP, VIM
44	thymidine32 18	6.3	EPO, HGF, CXCL12, TGFB2, TGFB1, TIMP2
45	genistein32 9 18 9	8.0	MMP3, FN1, FGF2, IL6, CCL2, IGF1
46	serine32	4.7	COL2A1, PLOD1, PLAT, CTSA, CTGF, SRF
47	actinomycin d32	4.7	HGF, CXCL12, PRG2, CCL2, IL6, FGF2
48	retinoic acid32 42 18	6.1	MMP3, GAP43, HGF, RLBP1, PRG2, TGFB2
49	dexamethasone32 42 34 9 9	7.7	COL2A1, ENO2, IL6, FGF2, FN1, MMP3
50	cycloheximide32	3.5	VIM, TGFB2, TGFB1, TIMP2, TIMP1, GFAP

Cellular components related to retinal detachment according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	basement membrane	GO:005604	10.1	LEPREL1, COL2A1, TIMP1, TIMP2, TGFB2
2	endoplasmic reticulum lumen	GO:005788	9.6	PDGFB, PDGFA, COL9A1, COL2A1, COL11A1, COL18A1
3	extracellular matrix	GO:031012	9.1	SOD1, TGFBI, TGFB2, NDP, COL18A1, PLAT
4	cell surface	GO:009986	8.6	PDGFB, TIMP2, TGFB1, TGFB2, PDGFA, PLAT
5	proteinaceous extracellular matrix	GO:005578	8.6	ADAMTS18, TGFBI, TGFB1, ELN, CTGF, FN1
6	platelet alpha granule lumen	GO:031093	8.0	HGF, TGFB2, TGFB1, TIMP1, EGF, PDGFB
7	extracellular space	GO:005615	3.3	EPO, HMGB1, IFNG, LOX, IGF1, CCL2
8	extracellular region	GO:005576	3.0	EPO, HGF, NPPA, SOD1, COL9A2, PLAT

Biological processes related to retinal detachment according to GeneDecks:

(show top 50)    (show all 58)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of protein autophosphorylation	GO:031954	10.5	PDGFB, PDGFA, VEGFA
2	collagen fibril organization	GO:030199	10.5	TGFB2, COL2A1, COL11A1, LOX
3	cell migration involved in sprouting angiogenesis	GO:002042	10.2	SRF, FGF2, VEGFA
4	visual perception	GO:007601	10.2	RLBP1, TGFBI, NDP, COL2A1, COL11A1, COL18A1
5	lung development	GO:030324	10.1	CTGF, HMGB1, LOX, FGF2, JMJD6
6	response to amino acid stimulus	GO:043200	10.1	CCL2, SST, CTGF, EDN1
7	positive regulation of endothelial cell proliferation	GO:001938	10.1	CXCL12, PDGFB, CCL2, FGF2, VEGFA
8	positive regulation of blood vessel endothelial cell migration	GO:043536	10.0	VEGFA, FGF2, PDGFB, TGFB1
9	monocyte chemotaxis	GO:002548	10.0	PDGFB, CCL2, IL6
10	superoxide metabolic process	GO:006801	9.9	CBS, NOS2, SOD1
11	positive regulation of cell division	GO:051781	9.9	TGFB2, TGFB1, PDGFB, PDGFA, FGF2, VEGFA
12	response to estradiol stimulus	GO:032355	9.9	ENO2, CTGF, PDGFB, TGFB1, TGFB2
13	blood vessel remodeling	GO:001974	9.9	TGFB2, ELN, CBS, IGF1
14	positive regulation of DNA replication	GO:045740	9.8	EPO, PDGFB, PDGFA, IGF1
15	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.8	PDGFB, PDGFA, CTGF, TNF, FGF2
16	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	9.8	HGF, TGFB2, PDGFB, PDGFA, IGF1
17	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.7	NDP, SRF, TNF, IL6, FZD4
18	glial cell differentiation	GO:010001	9.7	GAP43, IGF1, FGF2
19	response to heat	GO:009408	9.7	CCL2, SST, CXCL12, SOD1
20	aging	GO:007568	9.7	EPO, TGFB2, TGFB1, TIMP1, CCL2, SERPINF1
21	response to wounding	GO:009611	9.6	GAP43, TGFB2, TGFB1, GFAP, PDGFB, PDGFA
22	positive regulation of cell migration	GO:030335	9.6	TGFB1, EDN1, PDGFB, PDGFA, VEGFA
23	positive regulation of protein complex assembly	GO:031334	9.6	TGFB1, TNF, VEGFA
24	positive regulation of cerebellar granule cell precursor proliferation	GO:021940	9.6	FGF2, IGF1, EGF
25	neutrophil chemotaxis	GO:030593	9.5	TGFB2, EDN1, IFNG, CCL2
26	positive regulation of MAPK cascade	GO:043410	9.4	PDGFB, PDGFA, IGF1, IL6, LEP
27	organ morphogenesis	GO:009887	9.4	ELN, PDGFA, COL9A1, COL18A1, TNF, CCL2
28	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	VEGFA, IL6, IGF1, PDGFB, HGF
29	cell growth	GO:016049	9.4	TGFB2, TGFB1, EDN1, PDGFB
30	angiogenesis	GO:001525	9.3	TGFBI, TGFB2, TSPAN12, EGF, PDGFA, CTGF
31	activation of MAPK activity	GO:000187	9.3	HGF, SOD1, TNF, IKBKG, FGF2
32	positive regulation of peptidyl-serine phosphorylation	GO:033138	9.2	TGFB1, TNF, IL6, VEGFA
33	response to glucocorticoid stimulus	GO:051384	9.2	PLAT, TNF, HMGB1, CCL2, IL6, SERPINF1
34	extracellular matrix organization	GO:030198	9.1	LEPREL1, ADAMTSL4, TIMP2, TIMP1, GFAP, ELN
35	cell surface receptor signaling pathway	GO:007166	9.1	TSPAN12, EDN1, SST, IFNG, CCL2, JMJD6
36	organ regeneration	GO:031100	9.1	HGF, CXCL12, TGFB1, CCL2
37	positive regulation of smooth muscle cell proliferation	GO:048661	9.1	EDN1, PDGFB, TNF, IGF1, IL6
38	positive regulation of MAP kinase activity	GO:043406	9.1	TGFB1, EGF, EDN1, PDGFB, PDGFA, TNF
39	negative regulation of apoptotic process	GO:043066	9.0	EPO, CXCL12, TGFB2, TIMP1, COL2A1, TNF
40	positive regulation of mitosis	GO:045840	9.0	EGF, EDN1, PDGFB, TNF, IGF1, LRP5
41	humoral immune response	GO:006959	8.8	IL6, CCL2, IFNG, TNF
42	platelet degranulation	GO:002576	8.2	HGF, SOD1, TGFB2, TGFB1, TIMP1, EGF
43	response to hypoxia	GO:001666	8.0	PDGFB, EDN1, TGFB1, TGFB2, CXCL12, NOS2
44	response to drug	GO:042493	7.9	SOD1, TGFB2, TGFB1, EDN1, PDGFB, SST
45	negative regulation of cell proliferation	GO:008285	7.8	TGFB2, TGFB1, TIMP2, COL18A1, SRF, SST
46	platelet activation	GO:030168	7.7	TIMP1, TGFB1, TGFB2, SOD1, HGF, EGF
47	positive regulation of transcription, DNA-dependent	GO:045893	7.6	EPO, TGFB1, EGF, NDP, PDGFB, TNF
48	blood coagulation	GO:007596	7.5	TIMP1, TGFB1, TGFB2, SOD1, HGF, EGF
49	positive regulation of cell proliferation	GO:008284	7.4	EDN1, EGF, TIMP1, TGFB1, TGFB2, EPO
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.2	TGFB1, SRF, TNF, HMGB1, IFNG, IGF1

Molecular functions related to retinal detachment according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cell surface binding	GO:043498	10.5	NDP, PDGFB, PDGFA, VEGFA
2	extracellular matrix structural constituent conferring tensile strength	GO:030020	10.4	COL9A2, COL2A1, COL9A1
3	platelet-derived growth factor binding	GO:048407	10.3	COL2A1, PDGFA, PDGFB
4	platelet-derived growth factor receptor binding	GO:005161	10.2	PDGFB, PDGFA, VEGFA
5	chemoattractant activity	GO:042056	10.0	VEGFA, FGF2, HMGB1
6	eukaryotic cell surface binding	GO:043499	9.8	EPO, TGFB1, PDGFB, PDGFA
7	extracellular matrix binding	GO:050840	9.8	VEGFA, COL11A1, ELN
8	integrin binding	GO:005178	9.5	TGFBI, TIMP2, GFAP, CTGF, IGF1
9	heparin binding	GO:008201	9.5	PRG2, CTGF, CCL2, FGF2, FN1, VEGFA
10	protein heterodimerization activity	GO:046982	9.4	HGF, TGFB2, TGFB1, PDGFB, PDGFA, ENO2
11	hormone activity	GO:005179	8.9	EPO, NPPA, EDN1, SST, IGF1, LEP
12	protein homodimerization activity	GO:042803	8.9	PDGFA, PDGFB, NDP, TGFB1, TGFB2, SOD1
13	cytokine activity	GO:005125	8.2	TGFB2, EDN1, NDP, TNF, HMGB1, IFNG
14	growth factor activity	GO:008083	7.3	VEGFA, HGF, CXCL12, TGFB2, TGFB1, EGF
15	protein binding	GO:005515	4.5	ELN, EGF, RHO, PDGFB, COL18A1, NOS2