MCID: RTN017
MIFTS: 55

Retinal Detachment malady

Eye diseases category
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Summaries for Retinal Detachment

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Sources:
34MedlinePlus, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 The retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. it provides the sharp, central vision needed for reading, driving, and seeing fine detail. a retinal detachment lifts or pulls the retina from its normal position. it can occur at any age, but it is more common in people over age 40. it affects men more than women and whites more than african americans. a retinal detachment is also more likely to occur in people who are extremely nearsighted have had a retinal detachment in the other eye have a family history of retinal detachment have had cataract surgery have other eye diseases or disorders have had an eye injury symptoms include an increase in the number of floaters, which are little "cobwebs" or specks that float about in your field of vision, and/or light flashes in the eye. it may also seem like there is a "curtain" over your field of vision. a retinal detachment is a medical emergency. if not promptly treated, it can cause permanent vision loss. if you have any symptoms, see an eye care professional immediately. treatment includes different types of surgery. nih: national eye institute

MalaCards: Retinal Detachment is related to proliferative vitreoretinopathy and macular holes. An important gene associated with Retinal Detachment is COL2A1 (collagen, type II, alpha 1), and among its related pathways are Endochondral Ossification and Renal cell carcinoma. The compounds cystine and alginate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related mouse phenotypes are pigmentation and renal/urinary system.

Wikipedia:65 Retinal detachment is a disorder of the eye in which the retina peels away from its underlying layer of... more...

Description from OMIM:47 312530

Aliases & Classifications for Retinal Detachment

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Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 47OMIM, 27ICD9CM, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

retinal detachment 8 10 45 34 62


External Ids:

Disease Ontology8 DOID:5327
OMIM47 312530
ICD9CM27 361.9
MeSH35 D012163
NCIt40 C26874
ICD1025 H33.0

Related Diseases for Retinal Detachment

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Retinal Detachment via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 240)
idRelated DiseaseScoreTop Affiliating Genes
1proliferative vitreoretinopathy31.6TGFB2
2macular holes31.5TGFB2, SERPINF1
3retinoschisis31.5RS1
4diabetic retinopathy31.0PDGFB, SERPINF1, TGFB2
5proliferative diabetic retinopathy30.9GFAP, TGFB2, SERPINF1
6retinopathy of prematurity30.8FZD4
7uveitis30.6SERPINF1, TGFB2
8melanoma30.6GAP43, TGFB2, SERPINF1, COL2A1, PDGFB
9blindness30.5SERPINF1, RS1, COL2A1
10retinoblastoma30.1TGFB2, GFAP, SERPINF1
11retinal degeneration30.0RS1, SERPINF1, GFAP
12meningioma30.0GLUL, PDGFB, GFAP
13retinitis11.5
14choroiditis10.8
15coloboma10.7
16cataract10.7
17cytomegalovirus retinitis10.6
18retinal vein occlusion10.6
19vitreous detachment10.5
20myopia10.5
21coats disease10.5
22glaucoma10.5
23central serous chorioretinopathy10.5
24cystoid macular edema10.5
25exudative vitreoretinopathy10.5
26hellp syndrome10.5
27scleritis10.5
28stickler syndrome10.4
29chorioretinitis10.4
30endotheliitis10.4
31thrombotic thrombocytopenic purpura10.4
32central retinal vein occlusion10.4
33sympathetic ophthalmia10.4
34hemangioma10.4
35hypertension10.4
36purpura10.4
37eclampsia10.4
38scleral staphyloma10.4
39strabismus10.4
40sturge-weber syndrome10.4
41weber syndrome10.4
42neovascular glaucoma10.3
43diabetic macular edema10.3
44neuronitis10.3
45aniridia10.3
46vogt-koyanagi-harada disease10.3
47acute retinal necrosis syndrome10.3
48pre-eclampsia10.3
49knobloch syndrome10.3
50stickler syndrome type 110.3

Graphical network of the top 20 diseases related to Retinal Detachment:



Diseases related to retinal detachment

Symptoms for Retinal Detachment

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47OMIM
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Clinical features from OMIM:

312530

Drugs & Therapeutics for Retinal Detachment

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Retinal Detachment

Search NIH Clinical Center for Retinal Detachment

Genetic Tests for Retinal Detachment

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Anatomical Context for Retinal Detachment

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33MalaCards
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MalaCards organs/tissues related to Retinal Detachment:

33
Eye, Retina, Brain, Endothelial, Liver, Kidney, Breast, Monocytes, Cortex

Animal Models for Retinal Detachment or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Retinal Detachment:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.9RS1, SERPINF1, FZD4, PDGFB
2MP:00053678.7PDGFB, COL2A1, FZD4, TGFB2
3MP:00053698.0GFAP, TGFB2, FZD4, PDGFB
4MP:00053818.0GFAP, TGFB2, SERPINF1, FZD4, COL2A1
5MP:00053877.7GAP43, PDGFB, COL2A1, TGFB2, GFAP
6MP:00053857.6GFAP, TGFB2, SERPINF1, FZD4, COL2A1, PDGFB
7MP:00053787.1GFAP, TGFB2, FZD4, COL2A1, PDGFB, GLUL
8MP:00107686.9GFAP, TGFB2, FZD4, COL2A1, PDGFB, GLUL
9MP:00053916.7GAP43, RS1, GFAP, TGFB2, SERPINF1, FZD4
10MP:00036316.3RS1, GFAP, TGFB2, SERPINF1, FZD4, COL2A1

Publications for Retinal Detachment

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Sources:
52PubMed
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Articles related to Retinal Detachment:

(show top 50)    (show all 875)
idTitleAuthorsYear
1
Retinal detachment after open globe injury. (24011994)
2014
2
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
3
Surgical repair of macular fold after vitrectomy for bullous rhegmatogenous retinal detachment. (23481455)
2013
4
Management of rhegmatogenous retinal detachment with coexisting macular hole: a comparison of vitrectomy with and without internal limiting membrane peeling. (23222496)
2013
5
Anatomic and functional outcomes of 25-gauge vitrectomy for repair of eyes with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy. (24143072)
2013
6
Flashes, floaters, and oral fluoroquinolones: is retinal detachment a worry? (23307216)
2013
7
Bilateral retinal detachment with subsequent blindness in a pregnant woman with severe pre-eclampsia. (23548240)
2013
8
Post-operative hospitalization in retinal detachment correlation to recurrences. (24334776)
2013
9
Dalen Fuch's nodules and serous retinal detachment on optical coherence tomography in sympathetic ophthalmitis. (23760454)
2013
10
Episcleral macular buckling for posterior retinal detachment in silicone oil filled eyes associated with myopic macular hole. (23638417)
2013
11
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (23585552)
2013
12
Controversy over the etiology and therapy of retinal detachment: the struggles of Jules Gonin. (23257154)
2013
13
Characteristics of rhegmatogenous retinal detachment and their relationship to visual outcome. (23788207)
2013
14
A case of Alagille syndrome complicated by intraocular lens subluxation and rhegmatogenous retinal detachment. (23898221)
2013
15
A developmental mechanism of spontaneous reattachment in rhegmatogenous retinal detachment. (22511841)
2012
16
Familial retinal detachment associated with COL2A1 exon 2 and FZD4 mutations. (22574936)
2012
17
Functional and anatomical remodeling in human retinal detachment. (22406310)
2012
18
Persistent submacular fluid diagnosed with optical coherence tomography after successful scleral buckle surgery for macula-off retinal detachment. (22938546)
2012
19
Disappearance of extramacular drusen after chronic retinal detachment. (22557885)
2012
20
The fellow eye in retinal detachment: findings from the Scottish Retinal Detachment Study. (21378003)
2012
21
Longitudinal changes in retinal nerve fiber layer thickness after vitrectomy for rhegmatogenous retinal detachment. (22807292)
2012
22
The incidence of retinal detachment after cataract surgery. (23002414)
2012
23
Six months treatment with ibopamine in patients with hypotony after vitreoretinal surgery for retinal detachment, uveitis or penetrating trauma. (21909052)
2012
24
Bevacizumab for Coats' disease with exudative retinal detachment and risk of vitreoretinal traction. (21653215)
2012
25
Ultra-wide-field autofluorescence imaging in non-traumatic rhegmatogenous retinal detachment. (22722489)
2012
26
A chick model of retinal detachment: cone rich and novel. (22970190)
2012
27
Heavy internal tamponade for cases with complicated retinal detachment. (21484628)
2011
28
Persistent subretinal fluid due to central serous chorioretinopathy after retinal detachment surgery. (22069347)
2011
29
Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase. (21356360)
2011
30
Trends in primary retinal detachment surgery: results of a Bicenter study. (21242859)
2011
31
Cervicofacial subcutaneous emphysema and pneumomediastinum after retinal detachment surgery: just another monitored anesthesia eye case. (21723109)
2011
32
Contrast-enhanced ultrasonography in the differentiation of retinal detachment and vitreous membrane in dogs and cats. (21967099)
2011
33
Visual hallucinations from retinal detachment misdiagnosed as psychosis. (21430493)
2011
34
Apoptosis and other cell death mechanisms after retinal detachment: implications for photoreceptor rescue. (21778775)
2011
35
Cryptococcal-related exudative retinal detachment. (21546919)
2011
36
Assessment of the integrin alpha5beta1 antagonist JSM6427 in proliferative vitreoretinopathy using in vitro assays and a rabbit model of retinal detachment. (19815730)
2010
37
Outcome of scleral buckling procedures for primary rhegmatogenous retinal detachment. (21381585)
2010
38
Discriminate characteristics of photopsia in posterior vitreous detachment, retinal tears and retinal detachment. (19709374)
2010
39
Pediatric retinal detachment due to Coats' disease diagnosed with bedside emergency department ultrasound. (18226872)
2009
40
Retinal detachment causing unilateral blindness in a 12-year-old girl with gyrate atrophy. (19757146)
2009
41
Combined 5-fluorouracil, low-molecular-weight heparin, and silicone oil in the management of complicated retinal detachment with proliferative vitreoretinopathy grade C. (17674917)
2007
42
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
43
Submacular exudates with serous retinal detachment caused by cat scratch disease. (12778351)
2002
44
Concentration of vascular endothelial growth factor in the subretinal fluid of retinal detachment. (11110038)
2000
45
Use of perfluorocarbon liquid in the repair of retinoschisis retinal detachments. (8878197)
1996
46
Retinal detachment with a hiatus hernia. (8012680)
1994
47
Incidence of cystoid macular edema after retinal detachment surgery and the use of topical indomethacin. (6340512)
1983
48
Treatment of retinal detachment due to macular holes without chorio-retinal lesions. A seven-year follow-up study. (6963057)
1982
49
HEREDITARY RETINOSCHISIS WITH RETINAL DETACHMENT. (14137967)
1964
50
Retinal detachments occurring in cataract associated with neurodermatitis. (14932558)
1952

Variations for Retinal Detachment

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Expression for genes affiliated with Retinal Detachment

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Detachment

Search GEO for disease gene expression data for Retinal Detachment.

Pathways for genes affiliated with Retinal Detachment

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Sources:
50PathCards, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN, 55Reactome
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Compounds for genes affiliated with Retinal Detachment

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Sources:
45Novoseek, 24HMDB, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Retinal Detachment according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1cystine459.8GLUL, PDGFB
2alginate459.7COL2A1, TGFB2
32,3-cyclic nucleotide459.6GFAP, GLUL
4retinaldehyde459.6GLUL, GFAP
5quinolinic acid45 2410.5GFAP, GLUL
6glycosaminoglycan459.5COL2A1, SERPINF1, TGFB2
7nh4cl459.5GLUL, GFAP
8ascorbic acid45 2410.5TGFB2, COL2A1, GLUL
9orthophosphate459.4GAP43, GFAP
10n acetylcysteine459.3GLUL, SERPINF1, TGFB2
11silver459.2GLUL, PDGFB, GFAP
12ribonucleic acid459.2TGFB2, PDGFB, GAP43
13mptp459.1TGFB2, GFAP
14bromodeoxyuridine459.1GFAP, TGFB2, PDGFB
15dbc-amp459.0GAP43, GLUL, GFAP
16streptozotocin459.0GFAP, SERPINF1
17agar459.0GFAP, TGFB2, PDGFB
18polyacrylamide459.0GFAP, GLUL, GAP43
19gaba459.0GFAP, GLUL, GAP43
20matrigel458.9SERPINF1, TGFB2, GFAP
21oligonucleotide458.9TGFB2, COL2A1, PDGFB, GAP43
22arginine458.9GFAP, FZD4, COL2A1, GLUL
23nmda45 299.8GFAP, GLUL, GAP43
24ethanol45 51 24 1111.8GAP43, GLUL, GFAP
256-hydroxydopamine458.7GAP43, GFAP
26aspartate458.7GFAP, COL2A1, GLUL, GAP43
27paraffin458.7GFAP, TGFB2, PDGFB, GLUL
28potassium45 24 1110.7GFAP, TGFB2, SERPINF1
29thymidine45 249.7GFAP, TGFB2, PDGFB, GLUL
30adenylate458.6GAP43, GLUL, FZD4, GFAP
31alanine458.6GAP43, GLUL, COL2A1, GFAP
32dopamine45 29 24 1111.5GFAP, TGFB2, FZD4, GAP43
33methionine458.5GAP43, GLUL, SERPINF1, GFAP
34forskolin45 51 1110.5GAP43, TGFB2, GFAP
35vegf458.5GFAP, TGFB2, SERPINF1, PDGFB
36progesterone45 29 61 24 1112.4GAP43, PDGFB, TGFB2, GFAP
37threonine458.4GFAP, SERPINF1, GLUL, GAP43
38estrogen458.4GFAP, TGFB2, PDGFB, GLUL
39oxygen45 249.4GFAP, SERPINF1, COL2A1, PDGFB, GLUL
40lipid458.2GFAP, COL2A1, PDGFB, GLUL, GAP43
41glucose458.2GFAP, TGFB2, SERPINF1, PDGFB, GLUL
42retinoic acid45 249.1GFAP, TGFB2, SERPINF1, COL2A1, GAP43
43cycloheximide457.8GFAP, TGFB2, COL2A1, PDGFB, GLUL, GAP43
44nitric oxide45 24 119.7TGFB2, SERPINF1, FZD4, COL2A1, PDGFB, GLUL
45cysteine457.7GFAP, TGFB2, SERPINF1, COL2A1, GLUL, GAP43
46glutamate457.6GFAP, TGFB2, SERPINF1, FZD4, GLUL, GAP43
47calcium45 51 24 1110.3GFAP, TGFB2, SERPINF1, FZD4, COL2A1, GLUL
48dexamethasone45 51 29 1110.3GAP43, GFAP, TGFB2, SERPINF1, COL2A1, PDGFB
49serine457.2GFAP, TGFB2, SERPINF1, COL2A1, PDGFB, GLUL
50tyrosine457.2GFAP, TGFB2, SERPINF1, FZD4, PDGFB, GLUL

GO Terms for genes affiliated with Retinal Detachment

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16Gene Ontology
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Cellular components related to Retinal Detachment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5PDGFB, TGFB2
2extracellular spaceGO:0056158.0PDGFB, COL2A1, SERPINF1, TGFB2, RS1

Biological processes related to Retinal Detachment according to GeneCards/GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1cartilage condensationGO:0015029.9COL2A1, TGFB2
2heart morphogenesisGO:0030079.8COL2A1, TGFB2
3collagen fibril organizationGO:0301999.8TGFB2, COL2A1
4activation of protein kinase activityGO:0321479.7PDGFB, TGFB2
5positive regulation of cell divisionGO:0517819.6PDGFB, TGFB2
6positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.5TGFB2, PDGFB
7platelet degranulationGO:0025769.5PDGFB, TGFB2
8cell growthGO:0160499.4PDGFB, TGFB2
9hemopoiesisGO:0300979.2PDGFB, TGFB2
10cell proliferationGO:0082839.1GLUL, SERPINF1, TGFB2
11extracellular matrix organizationGO:0301988.6GFAP, TGFB2, COL2A1, PDGFB
12response to woundingGO:0096118.3GAP43, PDGFB, TGFB2, GFAP

Molecular functions related to Retinal Detachment according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet-derived growth factor bindingGO:0484079.6PDGFB, COL2A1
2identical protein bindingGO:0428029.3GLUL, PDGFB, COL2A1
3protein heterodimerization activityGO:0469828.8PDGFB, FZD4, TGFB2

Products for genes affiliated with Retinal Detachment

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Retinal Detachment

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet