Aliases & Classifications for Retinal Disease

MalaCards integrated aliases for Retinal Disease:

Name: Retinal Disease 12 14
Retinal Diseases 42 69
Retinal Disorders 41

Classifications:



External Ids:

Disease Ontology 12 DOID:5679
ICD10 33 H35.9 H36 H35.8
ICD9CM 35 362.9
MeSH 42 D012164
UMLS 69 C0035309

Summaries for Retinal Disease

MedlinePlus : 41 the retina is a layer of tissue in the back of your eye that senses light and sends images to your brain. in the center of this nerve tissue is the macula. it provides the sharp, central vision needed for reading, driving and seeing fine detail. retinal disorders affect this vital tissue. they can affect your vision, and some can be serious enough to cause blindness. examples are macular degeneration - a disease that destroys your sharp, central vision diabetic eye disease retinal detachment - a medical emergency, when the retina is pulled away from the back of the eye retinoblastoma - cancer of the retina. it is most common in young children. macular pucker - scar tissue on the macula macular hole - a small break in the macula that usually happens to people over 60 floaters - cobwebs or specks in your field of vision nih: national eye institute

MalaCards based summary : Retinal Disease, also known as retinal diseases, is related to leber congenital amaurosis and stargardt disease 1, and has symptoms including eye manifestations An important gene associated with Retinal Disease is CACNA1F (Calcium Voltage-Gated Channel Subunit Alpha1 F), and among its related pathways/superpathways are Phototransduction and Metabolism of fat-soluble vitamins. The drugs Acarbose and Pioglitazone have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are nervous system and pigmentation

Disease Ontology : 12 An eye disease that is located in the retina.

Related Diseases for Retinal Disease

Diseases related to Retinal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
id Related Disease Score Top Affiliating Genes
1 leber congenital amaurosis 32.1 AIPL1 CRB1 CRX GUCY2D RPE65
2 stargardt disease 1 31.7 ABCA4 CNGB3 CRX RHO
3 autosomal recessive cerebral atrophy 11.0 ABCA4 RPE65
4 cone-rod dystrophy 3 11.0 ABCA4 CACNA1F
5 meckel syndrome 4 11.0 CEP290 RPE65
6 actin-accumulation myopathy 11.0 ABCA4 PRPH2 RHO
7 methylmalonic aciduria, mut(0) type 11.0 BEST1 PRPH2
8 tuberculous peritonitis 11.0 AIPL1 GUCY2D PRPH2
9 collagen vi-related myopathy 11.0 PDE6B RHO
10 sulfate transporter-related osteochondrodysplasia 11.0 ABCA4 CNGB3
11 hypertropia 11.0 AIPL1 GUCY2D PRPH2
12 multiple familial trichoepithelioma 10.9 ARMS2 CFH
13 bladder disease 10.9 BEST1 PRPH2
14 leber congenital amaurosis 12 10.9 CEP290 GUCY2D RPE65
15 cerebellar ataxia, areflexia, pes cavus, optic atrophy and sensorinural hearing loss 10.9 ARMS2 CFH
16 joubert syndrome 10 10.9 CEP290 RPGR
17 endosalpingiosis 10.9 ARMS2 CFH
18 blessig's cysts 10.9 BEST1 PRPH2 RPGR
19 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 10.9 BEST1 RPGR
20 aloxe3-related autosomal recessive congenital ichthyosis 10.9 AIPL1 CEP290 GUCY2D RPE65
21 retinitis pigmentosa 19 10.9 ABCA4 PDE6B
22 rhizomelic chondrodysplasia punctata 10.9 ARMS2 CFH
23 osteogenesis imperfecta, type vi 10.8 PRPF31 RPGR
24 orofaciodigital syndrome xv 10.8 CNGB3 GUCY2D RPGR
25 asthma-related traits 8 10.8 MYO7A RHO RPGR USH2A
26 fundus dystrophy 10.8 CACNA1F PDE6B RHO
27 dystonia 16 10.8 CNGB3 GUCY2D RPGR
28 rpgrip1l-related meckel syndrome 10.8 AIPL1 CRX GUCY2D RPE65
29 androgenic alopecia 10.8 CNGB3 GUCY2D RPGR
30 ichthyosis, congenital, autosomal recessive 2 10.8 AIPL1 CRX GUCY2D RPE65
31 retinal degeneration 10.8
32 lumbosacral plexus lesion 10.8 ABCA4 CNGB3 RHO RPE65
33 acute biphenotypic leukemia 10.8 CNGB3 RPE65 RPGR
34 macular dystrophy, patterned, 1 10.8 PRPH2 RHO
35 jalili syndrome 10.8
36 somatization disorder 10.8 CNGB3 RHO
37 impetigo herpetiformis 10.8 CEP290 GUCY2D RHO RS1
38 leukodystrophy, hypomyelinating, 5 10.7 BEST1 CRB1
39 congenital hypogammaglobulinemia 10.7 CNGB3 RPE65
40 trichohepatoenteric syndrome 1 10.7 CRB1 MYO7A PDE6B USH2A
41 combined oxidative phosphorylation deficiency 3 10.7 CACNA1F PDE6B PRPH2 RHO RPE65
42 angiolipoma 10.7 PRPF31 PRPH2 RHO RPE65 RPGR
43 placental choriocarcinoma 10.7 ABCA4 ARMS2 CFH RHO RPE65
44 urofacial syndrome 1 10.7 CNGB3 RPGR
45 hereditary retinal dystrophy 10.7 CACNA1F RHO
46 iliac vein thrombophlebitis 10.7 ARMS2 CFH
47 histiocytic and dendritic cell cancer 10.7 ABCA4 ARMS2 CACNA1F CEP290 CFH
48 ciliary dyskinesia, primary, 9, with or without situs inversus 10.7 ABCA4 CRB1 CRX GUCY2D PRPH2
49 leber congenital amaurosis 9 10.6 AIPL1 CRB1 CRX GUCY2D RPE65
50 ventricular extrasystoles with syncope, perodactyly, and robin sequence 10.6 ABCA4 AIPL1 CEP290 CFH MYO7A RPE65

Graphical network of the top 20 diseases related to Retinal Disease:



Diseases related to Retinal Disease

Symptoms & Phenotypes for Retinal Disease

UMLS symptoms related to Retinal Disease:


eye manifestations

MGI Mouse Phenotypes related to Retinal Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.09 CFH CNGB3 CRB1 CRX GUCY2D MYO7A
2 pigmentation MP:0001186 9.8 ABCA4 BEST1 CEP290 CFH CRB1 CRX
3 vision/eye MP:0005391 9.6 CRX GUCY2D MYO7A PDE6B PRPF31 PRPH2

Drugs & Therapeutics for Retinal Disease

Drugs for Retinal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 768)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acarbose Approved, Investigational Phase 4,Phase 3,Early Phase 1 56180-94-0 441184
2
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
3
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 216974-75-3
4
Ranibizumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 347396-82-1 459903
5
Ketorolac Approved Phase 4,Phase 2,Phase 3,Phase 1 74103-06-3, 66635-83-4 3826
6
Hydroxocobalamin Approved Phase 4,Phase 2 13422-51-0 11953898 5460373 44475014
7
Fenofibrate Approved Phase 4,Phase 3,Phase 2 49562-28-9 3339
8
Glatiramer Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 147245-92-9 3081884
9
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
10
Verteporfin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 129497-78-5
11
Isosorbide Dinitrate Approved Phase 4 87-33-2 6883
12
Nitric Oxide Approved Phase 4,Phase 2,Phase 3 10102-43-9 145068
13
Acetazolamide Approved, Vet_approved Phase 4,Phase 3,Phase 2 59-66-5 1986
14
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 137-58-6 3676
15
Dorzolamide Approved Phase 4,Phase 2,Phase 3 120279-96-1 3154 5284549
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
17
Triamcinolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 124-94-7 31307
18
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
19
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
20
Insulin Glargine Approved Phase 4,Early Phase 1 160337-95-1
21
Zinc Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 7440-66-6 32051 23994
22
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
23 Povidone-iodine Approved Phase 4,Phase 3,Phase 2,Phase 1 25655-41-8
24
Eplerenone Approved Phase 4,Phase 2,Phase 3 107724-20-9 150310 443872
25
Spironolactone Approved Phase 4,Phase 2,Phase 3,Phase 1 1952-01-7, 52-01-7 5833
26
Temazepam Approved Phase 4,Phase 3,Phase 2,Phase 1 846-50-4 5391
27
Nepafenac Approved Phase 4,Phase 3,Phase 2 78281-72-8 151075
28
Ephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 299-42-3 9294
29
Pseudoephedrine Approved Phase 4,Phase 2,Phase 3,Phase 1 90-82-4 7028
30
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 67-73-2 6215
31
Diclofenac Approved, Vet_approved Phase 4,Phase 1 15307-86-5 3033
32
Cidofovir Approved Phase 4,Phase 3,Phase 2,Phase 1 113852-37-2 60613
33
Ganciclovir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 82410-32-0 3454
34
Foscarnet Approved Phase 4,Phase 3,Phase 2,Phase 1 63585-09-1, 4428-95-9 3415
35
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22916-47-8 4189
36
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
37
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
38
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2 2068-78-2, 57-22-7 5978
39 Poractant alfa Approved Phase 4 129069-19-8
40
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
41
Fluorouracil Approved Phase 4,Phase 3 51-21-8 3385
42
Insulin Aspart Approved Phase 4,Phase 3,Phase 2,Early Phase 1 116094-23-6 16132418
43
Metformin Approved Phase 4,Phase 3,Phase 2,Early Phase 1 657-24-9 14219 4091
44
Methotrexate Approved Phase 4,Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
45
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
46
Nitrous oxide Approved, Vet_approved Phase 4,Phase 3 10024-97-2 948
47
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
48
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
49
Latanoprost Approved, Investigational Phase 4,Phase 3,Phase 2 130209-82-4 5282380 5311221
50
Dipivefrin Approved Phase 4 52365-63-6 3105

Interventional clinical trials:

(show top 50) (show all 2771)

id Name Status NCT ID Phase Drugs
1 Macugen for Proliferative Diabetic Retinopathy Study With Extended Dosing (M-PDRS ED) Unknown status NCT01486771 Phase 4 Macugen ® (pegaptanib sodium)
2 Thiazolidinedione (TZD) on the Diabetic Retinopathy and Nephropathy Unknown status NCT01175486 Phase 4 Actos (Pioglitazone);Acarbose
3 Panretinal Photocoagulation for Proliferative Diabetic Retinopathy in a Single Session Using Low Fluence Parameters Unknown status NCT01023698 Phase 4
4 PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferative Diabetic Retinopathy Unknown status NCT02005432 Phase 4 Intravitreal Ranibizumabe;panfotocoagulation (PASCAL);panfotocoagulation (PRP) single shoot (ETDRS)
5 Efficient Study of ACULAR in Inhibiting Proliferative Retinopathy in Prematurity Unknown status NCT00634972 Phase 4 ACULAR;REFRESH TEARS;placebo
6 Effect of Doxium on High Sensitivity CRP and Endothelin-1 Serum Levels in Patients With Diabetic Retinopathy Unknown status NCT01382498 Phase 4 Calcium dobesilate (Doxium);Placebo drug
7 Use of Intravitreal Ranibizumab in the Treatment of Vitreous Hemorrhage Unknown status NCT01824043 Phase 4 intravitreal ranibizumab injections
8 Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy Unknown status NCT01921192 Phase 4 Folic Acid, vit B6 and B12;Placebo
9 Effects of Fenofibrate on Endothelial Progenitor Cells in Diabetes Unknown status NCT01927315 Phase 4 Fenofibrate 145 mg;Placebo
10 Ranibizumab in Diabetic Vitrectomy Unknown status NCT01306981 Phase 4 Ranibizumab;Saline
11 Effects of Copaxone in the Retinal Function in Diabetic Patients After Panphotocoagulation Unknown status NCT00677664 Phase 4 Glatiramer acetate (Copaxone);Mannitol
12 Changes in Macular Thickness After Patterns Scan Laser Unknown status NCT00563628 Phase 4
13 Changes in Electroretinogram and Contrast Sensitivity After PASCAL Treatment Unknown status NCT00563043 Phase 4
14 Cpap at Delivery Room for Preterm Infants Unknown status NCT01024361 Phase 4
15 Intravitreal Ranibizumab for the Prevention of Radiation Maculopathy Following Plaque Radiotherapy Unknown status NCT00540930 Phase 4 Ranibizumab
16 Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
17 Efficacy of Ranibizumab in Combination With Photodynamic Therapy for Wet Age-Related Macular Degeneration Unknown status NCT00813891 Phase 4 Ranibizumab;Ranibizumab;Ranibizumab
18 Aflibercept (EYLEA)as Secondary or Third Line Treatment for Neovascular Age-related Macular Degeneration. Unknown status NCT01918878 Phase 4 Aflibercept (EYLEA)
19 Comparison of the Effects of Bevacizumab Before vs After Pattern Panretinal Photocoagulation Unknown status NCT00804206 Phase 4 bevacizumab;bevacizumab
20 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
21 ALPI vs Medical Therapy Effects on Optic Nerve Structure & Function Unknown status NCT00485238 Phase 4 Intravenous acetazolamide
22 Withholding Feeds During Red Blood Cell Transfusion and TRAGI Unknown status NCT02132819 Phase 4
23 Multicenter Study to Evaluate the Efficacy of Treat and Extend Regimen of Aflibercept (EYLEA) as a Second Line Treatment for Diabetic Macular Edema Unknown status NCT02633852 Phase 4 Aflibercept
24 Adjunctive Local Application of Lidocaine During Scleral Buckling Under General Anesthesia Unknown status NCT01417572 Phase 4 lidocaine
25 On-label tReatment With Intravitreal Aflibercept injectiOn for Patients With Persistent Pigment epitheliaL Detachments in Neovascular Age Related Macular Degeneration (AMD) Unknown status NCT01670162 Phase 4 Aflibercept
26 The Endurance 1 Trial Unknown status NCT02297204 Phase 4 aflibercept 2.0 mg
27 Treat and Extend Therapy Study Using Intravitreal Aflibercept for Patients Exited From Protocol VGFT-OD 0910 Unknown status NCT01961414 Phase 4 Aflibercept
28 Treatment of Cystoid Macular Edema in Patients With Retinal Degeneration Unknown status NCT00716586 Phase 4 dorzolamide
29 A Clinical Trial to Explore the Safety and Efficacy of Injections of Macugen When Given Every 6 Weeks in Subjects With AMD Unknown status NCT00354445 Phase 4 pegaptanib sodium (Macugen)
30 Study to Evaluate Efficacy of Aflibercept in Neovascular Age-related Macular Degeneration Patients Non Responders to Anti-Vascular Endothelial Growth Factor Unknown status NCT01896284 Phase 4 0.5mg aflibercept
31 Effect of Dexamethasone Implant in Hard Exudate Complicated With Diabetic Macular Edema Unknown status NCT02399657 Phase 4 Intravitreal dexamethasone 0.7mg implant
32 POSTERIOR SUB-TENON'S Avastin Unknown status NCT00567372 Phase 4 bevacizumab (Sub-tenon´s injection)
33 Early CPAP in Respiratory Distress Syndrome Unknown status NCT00368680 Phase 4
34 Aflibercept Intravitreal Injection for Myopic Choroidal Neovascularization Unknown status NCT02033018 Phase 4 Aflibercept Injection
35 Retinal Sensitivity in BRVO After Anti-VEGF Therapy Unknown status NCT02527733 Phase 4 Ranibizumab;Ranibizumab and laser
36 Study of Intravitreal Aflibercept Injection for Persistent CRVO-associated Macular Edema Despite Prior Anti-VEGF Therapy Unknown status NCT01857544 Phase 4 Aflibercept
37 Evaluation of Changes in the Parameters of Optical Coherence Tomography After Intravitreal Injection of Lucentis Unknown status NCT01669447 Phase 4
38 Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema Unknown status NCT02055911 Phase 4 Ranibizumab
39 Treatment of Bevacizumab and Triamcinolone in Treatment or Macular Edema Secondary to CRVO Unknown status NCT00566761 Phase 4 bevacizumab and triamcinolone
40 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
41 Anesthesia for Retinopathy of Prematurity Completed NCT01955135 Phase 4 Ketamine;Sevoflurane;propofol
42 Topical Application of Latanoprost in Diabetic Retinopathy Completed NCT01225653 Phase 4 Latanoprost
43 Comparison of Insulin Glargine and NPH Human Insulin in Progression of Diabetic Retinopathy in Type 2 Diabetic Patients Completed NCT00174824 Phase 4 Insulin glargine
44 Intravitreal Bevacizumab for Surgical Treatment of Severe Proliferative Diabetic Retinopathy Completed NCT01025934 Phase 4 Bevacizumab
45 Intravitreal Bevacizumab for Proliferative Diabetic Retinopathy Completed NCT01724385 Phase 4 intravitreal injection of bevacizumab
46 Sucrose Analgesia for the Reduction of Pain During Retinopathy of Prematurity Screening Completed NCT00921544 Phase 4
47 Pain Using Reduced Fluence Parameters in Photocoagulation for Diabetic Retinopathy. Completed NCT00802269 Phase 4
48 Vascular Endothelial Growth Factor in Stage V ROP Completed NCT00500396 Phase 4
49 Effect of Levodopa on Human Multifocal Electroretinogram Completed NCT00812760 Phase 4 levodopa
50 Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy Completed NCT01854593 Phase 4 Bevacizumab

Search NIH Clinical Center for Retinal Disease

Cochrane evidence based reviews: retinal diseases

Genetic Tests for Retinal Disease

Anatomical Context for Retinal Disease

MalaCards organs/tissues related to Retinal Disease:

39
Eye, Endothelial, Retina, Testes, Bone, Brain, Lung

Publications for Retinal Disease

Articles related to Retinal Disease:

(show top 50) (show all 333)
id Title Authors Year
1
Comprehensive Rare Variant Analysis via Whole-Genome Sequencing to Determine the Molecular Pathology of Inherited Retinal Disease. ( 28041643 )
2017
2
The Blood-Retinal Barrier in the Management of Retinal Disease: EURETINA Award Lecture. ( 28152535 )
2017
3
Genetic Testing for Inherited Retinal Disease. ( 28823343 )
2017
4
Stem cell-derived retinal pigment epithelium transplantation for treatment of retinal disease. ( 28554398 )
2017
5
Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-I^ (PPARI^) are disrupted by retinal disease-associated mutations. ( 28300834 )
2017
6
Multisensory cue combination after sensory loss: Audio-visual localization in patients with progressive retinal disease. ( 28182481 )
2017
7
Telemedicine Applications in Pediatric Retinal Disease. ( 28333078 )
2017
8
An experimental comparison of human and bovine rhodopsin provides insight into the molecular basis of retinal disease. ( 28369862 )
2017
9
Unique cell biological profiles of retinal disease-causing missense mutations in the polarity protein Crumbs. ( 28515229 )
2017
10
Genome editing: the breakthrough technology for inherited retinal disease? ( 28695744 )
2017
11
Clinically Focused Molecular Investigation of 1000 Consecutive Families with Inherited Retinal Disease. ( 28559085 )
2017
12
Retinal miRNAs variations in a large cohort of inherited retinal disease. ( 28704127 )
2017
13
Genome-Wide Detection of Copy Number Variations in Unsolved Inherited Retinal Disease. ( 28118666 )
2017
14
Bestrophin 1 and retinal disease. ( 28153808 )
2017
15
Minireview: Fibronectin in retinal disease. ( 27798121 )
2017
16
Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations. ( 28749477 )
2017
17
Panel-Based Clinical Genetic Testing in 85 Children with Inherited Retinal Disease. ( 28341476 )
2017
18
Stem Cells for Retinal Disease: A Perspective on the Promise and Perils. ( 28428049 )
2017
19
Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension. ( 28951125 )
2017
20
Blur Adaptation to Central Retinal Disease. ( 28728172 )
2017
21
Safety and acceptability of an organic light-emitting diode sleep mask as a potential therapy for retinal disease. ( 27983728 )
2017
22
Evidence for Telemedicine for Diabetic Retinal Disease. ( 27748634 )
2017
23
Comparative sequence analyses of rhodopsin and RPE65 reveal patterns of selective constraint across hereditary retinal disease mutations. ( 26750628 )
2016
24
Molecular findings from 537 individuals with inherited retinal disease. ( 27208204 )
2016
25
Induced Pluripotent Stem Cells and Outer Retinal Disease. ( 26880948 )
2016
26
The clinical features of retinal disease due to a dominant mutation in RPE65. ( 27307694 )
2016
27
Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease. ( 26427396 )
2016
28
Author Response: Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1. ( 27737465 )
2016
29
Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: Central Retinal Enrichment Supplementation Trials - Report 1. ( 27367585 )
2016
30
Multimodal Imaging in Retinal Disease: A Consensus Definition. ( 26985792 )
2016
31
Investigation of SLA4A3 as a candidate gene for human retinal disease. ( 27211793 )
2016
32
Optical Coherence Tomography Angiography of Miscellaneous Retinal Disease. ( 27023316 )
2016
33
RGR variants in different forms of retinal diseases: The undetermined role of truncation mutations. ( 27748892 )
2016
34
Systemic confounders affecting serum measurements of omega-3 and -6 polyunsaturated fatty acids in patients with retinal disease. ( 27596098 )
2016
35
Clinical applications of fundus autofluorescence in retinal disease. ( 27847630 )
2016
36
How Was Your Sleep? New Implications for Obstructive Sleep Apnea in Retinal Disease. ( 26841214 )
2016
37
Clustered Regularly Interspaced Short Palindromic Repeats: Challenges in Treating Retinal Disease. ( 27488072 )
2016
38
Endogenous and Synthetic Cannabinoids as Therapeutics in Retinal Disease. ( 26881135 )
2016
39
Advanced Diagnostic Genetic Testing In Inherited Retinal Disease:Experience from a Single Tertiary Referral Centre in the UK National Health Service. ( 27160483 )
2016
40
A computer-assisted method for pathogenicity assessment and genetic reporting of variants stored in the Australian Inherited Retinal Disease Register. ( 26728880 )
2016
41
Wide field of view swept-source optical coherence tomography for peripheral retinal disease. ( 26755643 )
2016
42
Hsp90 as a Potential Therapeutic Target in Retinal Disease. ( 26427407 )
2016
43
Retinal disease in the C3 glomerulopathies and the risk of impaired vision. ( 26915021 )
2016
44
Intravitreal Steroid Implants in the Management of Retinal Disease and Uveitis. ( 27575764 )
2016
45
Telemedicine for a General Screening of Retinal Disease Using Nonmydriatic Fundus Cameras in Optometry Centers: Three-Year Results. ( 27228051 )
2016
46
Anti-angiogenic Therapy for Retinal Disease. ( 27783271 )
2016
47
Macromolecular markers in normal human retina and applications to human retinal disease. ( 26769220 )
2016
48
Whole Genome Sequencing Increases Molecular Diagnostic Yield Compared with Current Diagnostic Testing for Inherited Retinal Disease. ( 26872967 )
2016
49
Anti-Vascular Endothelial Growth Factor Agents in the Treatment of Retinal Disease: From Bench to Bedside. ( 27664289 )
2016
50
Cell therapy for retinal disease. ( 26859132 )
2016

Variations for Retinal Disease

Expression for Retinal Disease

Search GEO for disease gene expression data for Retinal Disease.

Pathways for Retinal Disease

GO Terms for Retinal Disease

Cellular components related to Retinal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 ciliary basal body GO:0036064 9.5 CEP290 RPGR USH2A
2 photoreceptor disc membrane GO:0097381 9.46 ABCA4 GUCY2D PDE6B RHO
3 photoreceptor connecting cilium GO:0032391 9.43 CEP290 MYO7A USH2A
4 photoreceptor inner segment GO:0001917 9.35 AIPL1 ARMS2 MYO7A RHO USH2A
5 photoreceptor outer segment GO:0001750 9.17 ABCA4 CACNA1F CNGB3 MYO7A PRPH2 RHO

Biological processes related to Retinal Disease according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 visual perception GO:0007601 9.83 ABCA4 AIPL1 BEST1 CACNA1F CNGB3 CRX
2 retinoid metabolic process GO:0001523 9.7 ABCA4 RHO RPE65
3 retina homeostasis GO:0001895 9.67 AIPL1 ARMS2 RPE65
4 photoreceptor cell maintenance GO:0045494 9.65 ABCA4 RHO USH2A
5 retina development in camera-type eye GO:0060041 9.62 PDE6B PRPH2 RHO RPE65
6 regulation of rhodopsin mediated signaling pathway GO:0022400 9.61 GUCY2D PDE6B RHO
7 eye photoreceptor cell development GO:0042462 9.58 CEP290 CRB1 MYO7A
8 rhodopsin mediated signaling pathway GO:0016056 9.54 PDE6B RHO
9 detection of light stimulus involved in visual perception GO:0050908 9.54 BEST1 CACNA1F RPE65
10 inner ear receptor cell differentiation GO:0060113 9.51 MYO7A USH2A
11 detection of light stimulus GO:0009583 9.46 PDE6B RHO
12 phototransduction, visible light GO:0007603 9.46 ABCA4 AIPL1 PDE6B RHO
13 response to stimulus GO:0050896 9.44 ABCA4 AIPL1 BEST1 CACNA1F CNGB3 CRX
14 sensory perception of light stimulus GO:0050953 9.43 MYO7A RHO USH2A

Sources for Retinal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....