MCID: RTN003
MIFTS: 49

Retinal Ischemia malady

Eye diseases category
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Summaries for Retinal Ischemia

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Wikipedia:65 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards based summary: Retinal Ischemia, also known as retinal ischaemia, is related to ischemia and diabetic retinopathy. An important gene associated with Retinal Ischemia is SETD2 (SET domain containing 2), and among its related pathways are Renal cell carcinoma and Signaling events mediated by VEGFR1 and VEGFR2. The compounds echinomycin and deferoxamine mesylate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and endothelial, and related mouse phenotypes are craniofacial and cardiovascular system.

Aliases & Classifications for Retinal Ischemia

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Retinal Ischemia, Aliases & Descriptions:

Name: Retinal Ischemia 30 8 44 62
 
Retinal Ischaemia 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


External Ids:

Disease Ontology8 DOID:12510
SNOMED-CT57 26468004, 193427006
ICD9CM27 362.84

Related Diseases for Retinal Ischemia

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Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia30.9ADORA1, SETD2, CASP2, HIF1A, VEGFA
2diabetic retinopathy30.6HIF1A, VEGFA
3proliferative diabetic retinopathy30.2VEGFA, HIF1A
4melanoma29.4SETD2, CASP2, VEGFA, HIF1A
5retinitis11.2
6neuronitis10.5
7endotheliitis10.5
8retinal vein occlusion10.3
9choroiditis10.3
10erythrocytosis10.2SETD2, HIF1A
11hypertension10.2
12neovascular glaucoma10.2
13temporal arteritis10.2
14central retinal artery occlusion10.2
15neurofibromatosis10.2
16cerebritis10.2
17retinal artery occlusion10.2
18hypoxia10.2
19pulmonary hypertension10.2SETD2, HIF1A
20hemangioblastoma10.1VEGFA, HIF1A
21von hippel-lindau disease10.1VEGFA, HIF1A
22kidney rhabdoid cancer10.1VEGFA, HIF1A
23artery disease10.1
24carotid artery disease10.1
25cervical cancer10.0SETD2, HIF1A
26coronary artery anomaly10.0SETD2, ADORA1
27adult t-cell leukemia10.0
28cataract10.0
29leukemia10.0
30multiple sclerosis10.0
31antiphospholipid syndrome10.0
32kawasaki disease10.0
33carotid stenosis10.0
34ocular hypertension10.0
35cervicitis10.0
36hyperglycemia10.0
37retinal detachment10.0
38t-cell leukemia10.0
39eales disease10.0
40wallerian degeneration10.0
41exudative vitreoretinopathy 410.0
42exudative vitreoretinopathy 110.0
43exudative vitreoretinopathy 2, x-linked10.0
44blindness10.0
45hypoglycemia10.0ADORA1, SETD2, HIF1A
46renal clear cell carcinoma10.0HIF1A, VEGFA, SETD2
47glioblastoma multiforme10.0VEGFA, SETD2, HIF1A
48squamous cell carcinoma of the head and neck9.9SETD2, HIF1A, VEGFA
49pre-eclampsia9.9SETD2, HIF1A, VEGFA
50congenital heart disease9.9HIF1A, VEGFA

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to retinal ischemia

Symptoms for Retinal Ischemia

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Drugs & Therapeutics for Retinal Ischemia

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Drug clinical trials:

Search ClinicalTrials for Retinal Ischemia

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family), PMIDs: 23049424, 21225138, 19347139, 23000646

Genetic Tests for Retinal Ischemia

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Anatomical Context for Retinal Ischemia

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MalaCards organs/tissues related to Retinal Ischemia:

32
Eye, Bone, Endothelial, Retina, Bone marrow, Spleen, Brain, T cells, B cells, Neutrophil

Animal Models for Retinal Ischemia or affiliated genes

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MGI Mouse Phenotypes related to Retinal Ischemia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9SETD2, HIF1A, VEGFA
2MP:00053858.1VEGFA, HIF1A, SETD2, ADORA1
3MP:00036317.4CASP2, ADORA1, SETD2, HIF1A, VEGFA

Publications for Retinal Ischemia

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Articles related to Retinal Ischemia:

(show top 50)    (show all 240)
idTitleAuthorsYear
1
Diffuse retinal ischemia following intravenous crushed oxymorphone abuse. (24921173)
2014
2
Peripheral retinal ischemia after intravenous tissue plasminogen activator for central retinal artery occlusion. (25284117)
2014
3
Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis. (24514073)
2014
4
Retinal ischemia/reperfusion injury is mediated by Toll-like receptor 4 activation of NLRP3 inflammasomes. (25097240)
2014
5
Protective effect of pioglitazone on retinal ischemia/reperfusion injury in rats. (23557740)
2013
6
Transplantation of induced pluripotent stem cells without C-Myc attenuates retinal ischemia and reperfusion injury in rats. (23726881)
2013
7
Baicalein protects against retinal ischemia by antioxidation, antiapoptosis, downregulation of HIF-1I+, VEGF, and MMP-9 and upregulation of HO-1. (23537149)
2013
8
Neovascular glaucoma induced by peripheral retinal ischemia in neurofibromatosis type 1: management and imaging features. (23687499)
2013
9
Preclinical models to investigate retinal ischemia: advances and drawbacks. (22593752)
2012
10
Enhanced expression of proneurotrophins in elevated introcular pressure-induced rat retinal ischemia. (23106891)
2012
11
Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. (21455561)
2011
12
Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. (21633713)
2011
13
Protective effects of catalase on retinal ischemia/reperfusion injury in rats. (21824472)
2011
14
Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. (20025059)
2010
15
Effect of 3(')-daidzein sulfonic sodium on the anti-oxidation of retinal ischemia/reperfusion injury in rats. (20238062)
2010
16
TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. (20554625)
2010
17
Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. (19862336)
2009
18
Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation. (19450446)
2009
19
Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats. (18565280)
2008
20
Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia. (17763865)
2008
21
Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion-induced alterations by acting as a hydroxyl radical scavenger. (18788996)
2008
22
Nicotinamide attenuates retinal ischemia and light insults to neurones. (17976861)
2008
23
Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. (18187343)
2008
24
Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome. (17508052)
2007
25
The involvement of matrix metalloproteinases 2 and 9 in rat retinal ischemia. (17024442)
2007
26
Bevacizumab and retinal ischemia. (17980746)
2007
27
Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. (17581795)
2007
28
Expression of antioxidant enzymes in rat retinal ischemia followed by reperfusion. (16784960)
2006
29
EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. (17026968)
2006
30
The effect of hyperglycemia on experimental retinal ischemia. (15006850)
2004
31
Mitogen-activated protein kinases and retinal ischemia. (14638742)
2003
32
Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. (11784707)
2002
33
Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. (11917000)
2002
34
Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. (12457864)
2002
35
Effect of trimetazidine on retinal ischemia/reperfusion injury in rats. (11399941)
2001
36
Leukocyte-endothelial cell interactions in diabetic retina after transient retinal ischemia. (10956257)
2000
37
Effect of CO(2) pneumoperitoneum on early cellular markers of retinal ischemia in rabbits with alpha-chymotrypsin-induced glaucoma. (11116419)
2000
38
Ischemic preconditioning attenuates hypoperfusion after retinal ischemia in rats. (10549654)
1999
39
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. (9579489)
1998
40
Cerebral microembolism in patients with retinal ischemia. (9626285)
1998
41
Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. (9425521)
1997
42
Ameliorative effect of MK-801 on retinal ischemia. (9090613)
1997
43
Involvement of adenosine in retinal ischemia. Studies on the rat. (8977474)
1996
44
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
45
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
46
Intraretinal study of cat electroretinogram during retinal ischemia-reperfusion with extracellular K+ concentration microelectrodes. (8113017)
1994
47
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
48
Subretinal neovascular membranes associated with choroidal nonperfusion and retinal ischemia. (2446561)
1987
49
Rod-cone differences in response to retinal ischemia in rabbit. (3803167)
1986
50
Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension. (745825)
1978

Variations for Retinal Ischemia

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Expression for genes affiliated with Retinal Ischemia

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Expression patterns in normal tissues for genes affiliated with Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for genes affiliated with Retinal Ischemia

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Compounds for genes affiliated with Retinal Ischemia

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Compounds related to Retinal Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1echinomycin449.9SETD2, HIF1A
2deferoxamine mesylate449.9HIF1A, SETD2
3pimonidazole449.9HIF1A, SETD2
4cocl2449.9SETD2, HIF1A
5apigenin44 2810.8SETD2, HIF1A
65-n-ethylcarboxamidoadenosine449.7ADORA1, VEGFA
7su5416449.7VEGFA, HIF1A
8everolimus44 50 1111.7VEGFA, HIF1A
9sunitinib44 50 1111.6VEGFA, HIF1A
10apocynin44 6110.6SETD2, VEGFA
11nickel44 2410.6HIF1A, SETD2
12candesartan44 50 28 1112.6VEGFA, HIF1A
1317-(allylamino)-17-demethoxygeldanamycin449.5HIF1A, SETD2
14deferoxamine44 1110.5SETD2, HIF1A
15verteporfin449.4CASP2, VEGFA
16radicicol44 61 1111.4HIF1A, VEGFA
17gsno449.4HIF1A, SETD2
183-(5-hydroxymethyl-2-furyl)-1-benzylindazole449.3VEGFA, SETD2, HIF1A
19cobalt chloride449.3SETD2, HIF1A, VEGFA
20topotecan44 1110.3SETD2, VEGFA, HIF1A
21diphenyleneiodonium449.3HIF1A, VEGFA, SETD2
22bortezomib44 50 1111.3VEGFA, HIF1A, SETD2
23geldanamycin44 50 61 1112.3HIF1A, VEGFA, SETD2
24n acetylcysteine449.2HIF1A, VEGFA, SETD2
25sb 20358044 6110.2HIF1A, VEGFA, SETD2
26rapamycin449.2HIF1A, VEGFA, SETD2
27phosphoinositide449.2ADORA1, HIF1A, SETD2
28ly294002449.1SETD2, VEGFA, HIF1A
29actinomycin d449.1SETD2, HIF1A, VEGFA
30sp 60012544 6110.1HIF1A, SETD2, CASP2
31camptothecin44 61 1111.1CASP2, HIF1A, SETD2
32etoposide44 50 61 1112.0HIF1A, SETD2, CASP2
33ascorbic acid44 2410.0SETD2, CASP2, HIF1A
34butyrate449.0SETD2, CASP2, HIF1A
35flavopiridol44 119.9CASP2, HIF1A, VEGFA
36wortmannin448.9HIF1A, SETD2, CASP2
37resveratrol44 61 24 1111.9VEGFA, HIF1A, CASP2
38mg 13244 619.9VEGFA, CASP2, HIF1A
395fluorouracil448.9VEGFA, CASP2, HIF1A
40genistein44 28 61 2 24 1113.8VEGFA, ADORA1, HIF1A, SETD2
41estrogen448.7SETD2, ADORA1, HIF1A, VEGFA
42paraffin448.7HIF1A, VEGFA, CASP2
43bapta448.6ADORA1, CASP2, SETD2, HIF1A
44pge2448.6HIF1A, VEGFA, SETD2
45atp44 289.5ADORA1, SETD2, HIF1A, CASP2
46docetaxel44 50 61 1111.5HIF1A, SETD2, CASP2, VEGFA
47arsenite44 249.5CASP2, HIF1A, VEGFA, SETD2
48paclitaxel44 50 1110.5VEGFA, CASP2, SETD2, HIF1A
49doxorubicin44 50 1110.5CASP2, SETD2, VEGFA, HIF1A
50cisplatin44 50 61 1111.5HIF1A, VEGFA, CASP2, SETD2

GO Terms for genes affiliated with Retinal Ischemia

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Biological processes related to Retinal Ischemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.6HIF1A, VEGFA
2dopaminergic neuron differentiationGO:0715429.6HIF1A, VEGFA
3positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.5HIF1A, VEGFA
4positive regulation of neuroblast proliferationGO:0020529.5HIF1A, VEGFA
5regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.5VEGFA, HIF1A
6outflow tract morphogenesisGO:0031519.4HIF1A, VEGFA
7lactationGO:0075959.4HIF1A, VEGFA
8positive regulation of endothelial cell proliferationGO:0019389.3VEGFA, HIF1A
9cellular response to hypoxiaGO:0714569.2HIF1A, VEGFA
10apoptotic signaling pathwayGO:0971909.1CASP2, ADORA1
11angiogenesisGO:0015259.1VEGFA, HIF1A, SETD2
12response to hypoxiaGO:0016669.1ADORA1, HIF1A, VEGFA
13positive regulation of angiogenesisGO:0457669.0HIF1A, VEGFA

Molecular functions related to Retinal Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:0469828.5ADORA1, HIF1A, VEGFA
2protein bindingGO:0055157.5CASP2, ADORA1, SETD2, HIF1A, VEGFA

Products for genes affiliated with Retinal Ischemia

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  • Antibodies
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Sources for Retinal Ischemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet