MCID: RTN003
MIFTS: 48

Retinal Ischemia malady

Eye diseases category
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Summaries for Retinal Ischemia

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Ischemia, also known as retinal ischaemia, is related to ischemia and diabetic retinopathy. An important gene associated with Retinal Ischemia is SETD2 (SET domain containing 2), and among its related pathways are Renal cell carcinoma and Signaling events mediated by VEGFR1 and VEGFR2. The compounds echinomycin and deferoxamine mesylate have been mentioned in the context of this disorder. Affiliated tissues include eye, bone and endothelial, and related mouse phenotypes are craniofacial and cardiovascular system.

Aliases & Classifications for Retinal Ischemia

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8Disease Ontology, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 27ICD9CM, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

retinal ischemia 8 45 31 62
retinal ischaemia 8


External Ids:

Disease Ontology8 DOID:12510
SNOMED-CT58 193427006, 26468004
ICD9CM27 362.84

Related Diseases for Retinal Ischemia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 70)
idRelated DiseaseScoreTop Affiliating Genes
1ischemia31.6ADORA1, SETD2, CASP2, HIF1A, VEGFA
2diabetic retinopathy30.5HIF1A, VEGFA
3proliferative diabetic retinopathy30.0VEGFA, HIF1A
4melanoma29.9SETD2, CASP2, VEGFA, HIF1A
5retinitis11.2
6neuronitis10.5
7endotheliitis10.5
8glaucoma10.3
9choroiditis10.2
10retinal vein occlusion10.2
11neurofibromatosis10.2
12neovascular glaucoma10.2
13cerebritis10.2
14temporal arteritis10.2
15cataract10.2
16hypertension10.2
17hypoxia10.2
18artery disease10.1
19carotid artery disease10.1
20erythrocytosis10.0SETD2, HIF1A
21primary pulmonary hypertension10.0SETD2, HIF1A
22hemangioblastoma10.0VEGFA, HIF1A
23von hippel-lindau disease10.0VEGFA, HIF1A
24kidney rhabdoid cancer10.0VEGFA, HIF1A
25coronary artery disease10.0SETD2, ADORA1
26cervical cancer10.0SETD2, HIF1A
27antiphospholipid syndrome10.0
28ocular hypertension10.0
29exudative vitreoretinopathy10.0
30adult t-cell leukemia10.0
31kawasaki disease10.0
32central retinal artery occlusion10.0
33carotid stenosis10.0
34cervicitis10.0
35hyperglycemia10.0
36leukemia10.0
37multiple sclerosis10.0
38retinal artery occlusion10.0
39t-cell leukemia10.0
40eales disease10.0
41wallerian degeneration10.0
42exudative vitreoretinopathy 410.0
43exudative vitreoretinopathy, x-linked10.0
44blindness10.0
45hypoglycemia10.0ADORA1, SETD2, HIF1A
46renal clear cell carcinoma10.0HIF1A, VEGFA, SETD2
47squamous cell carcinoma of the head and neck10.0SETD2, HIF1A, VEGFA
48pre-eclampsia10.0SETD2, HIF1A, VEGFA
49congenital heart disease10.0HIF1A, VEGFA
50colorectal cancer10.0VEGFA, HIF1A, SETD2

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to retinal ischemia

Symptoms for Retinal Ischemia

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Drugs & Therapeutics for Retinal Ischemia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Retinal Ischemia

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family), PMIDs: 23049424, 21225138, 19347139, 23000646

Genetic Tests for Retinal Ischemia

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Anatomical Context for Retinal Ischemia

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33MalaCards
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MalaCards organs/tissues related to Retinal Ischemia:

33
Eye, Bone, Endothelial, Retina, Spleen, Brain, T cells, B cells

Animal Models for Retinal Ischemia or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Retinal Ischemia:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053828.9SETD2, HIF1A, VEGFA
2MP:00053858.1VEGFA, HIF1A, SETD2, ADORA1
3MP:00036317.4CASP2, ADORA1, SETD2, HIF1A, VEGFA

Publications for Retinal Ischemia

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Sources:
52PubMed
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Articles related to Retinal Ischemia:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Protective effect of pioglitazone on retinal ischemia/reperfusion injury in rats. (23557740)
2013
2
Transplantation of induced pluripotent stem cells without C-Myc attenuates retinal ischemia and reperfusion injury in rats. (23726881)
2013
3
Baicalein protects against retinal ischemia by antioxidation, antiapoptosis, downregulation of HIF-1I+, VEGF, and MMP-9 and upregulation of HO-1. (23537149)
2013
4
Neovascular glaucoma induced by peripheral retinal ischemia in neurofibromatosis type 1: management and imaging features. (23687499)
2013
5
Preclinical models to investigate retinal ischemia: advances and drawbacks. (22593752)
2012
6
Enhanced expression of proneurotrophins in elevated introcular pressure-induced rat retinal ischemia. (23106891)
2012
7
Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. (21455561)
2011
8
Inhalative preconditioning with hydrogen sulfide attenuated apoptosis after retinal ischemia/reperfusion injury. (21633713)
2011
9
Protective effects of catalase on retinal ischemia/reperfusion injury in rats. (21824472)
2011
10
Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. (20025059)
2010
11
Effect of 3(')-daidzein sulfonic sodium on the anti-oxidation of retinal ischemia/reperfusion injury in rats. (20238062)
2010
12
TRPC6 channel protects retinal ganglion cells in a rat model of retinal ischemia/reperfusion-induced cell death. (20554625)
2010
13
Neuroprotection against retinal ischemia-reperfusion injury by blocking the angiotensin II type 1 receptor. (20164447)
2010
14
Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion. (20300568)
2010
15
Retinal ischemia-induced apoptosis is associated with alteration in Bax and Bcl-x(L) expression rather than modifications in Bak and Bcl-2. (19862336)
2009
16
Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation. (19450446)
2009
17
Edaravone (MCI-186), a free radical scavenger, attenuates retinal ischemia/reperfusion injury in rats. (18565280)
2008
18
Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemia. (17763865)
2008
19
Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion-induced alterations by acting as a hydroxyl radical scavenger. (18788996)
2008
20
Nicotinamide attenuates retinal ischemia and light insults to neurones. (17976861)
2008
21
Evolving Wallerian degeneration after transient retinal ischemia in mice characterized by diffusion tensor imaging. (18187343)
2008
22
Localized retinal ischemia as an ocular manifestation of primary antiphospholipid syndrome. (17508052)
2007
23
The involvement of matrix metalloproteinases 2 and 9 in rat retinal ischemia. (17024442)
2007
24
Bevacizumab and retinal ischemia. (17980746)
2007
25
Gender differences in the effect of aspirin on retinal ischemia, prostanoid synthesis and nitric oxide production in experimental type 1-like diabetes. (17581795)
2007
26
Expression of antioxidant enzymes in rat retinal ischemia followed by reperfusion. (16784960)
2006
27
EDG receptors as a potential therapeutic target in retinal ischemia-reperfusion injury. (17026968)
2006
28
The effect of hyperglycemia on experimental retinal ischemia. (15006850)
2004
29
Mitogen-activated protein kinases and retinal ischemia. (14638742)
2003
30
Retinal ganglion cell death after acute retinal ischemia is an ongoing process whose severity and duration depends on the duration of the insult. (11784707)
2002
31
Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. (11917000)
2002
32
Loss of retinal ganglion cells following retinal ischemia: the role of inducible nitric oxide synthase. (12457864)
2002
33
Echocardiographic findings of patients with retinal ischemia or embolism. (12116739)
2002
34
Effect of trimetazidine on retinal ischemia/reperfusion injury in rats. (11399941)
2001
35
Leukocyte-endothelial cell interactions in diabetic retina after transient retinal ischemia. (10956257)
2000
36
Effect of CO(2) pneumoperitoneum on early cellular markers of retinal ischemia in rabbits with alpha-chymotrypsin-induced glaucoma. (11116419)
2000
37
Ischemic preconditioning attenuates hypoperfusion after retinal ischemia in rats. (10549654)
1999
38
Memantine is neuroprotective in a rat model of pressure-induced retinal ischemia. (9579489)
1998
39
Cerebral microembolism in patients with retinal ischemia. (9626285)
1998
40
Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCbeta inhibition with LY333531. (9430559)
1998
41
Retinal ischemia leads to apoptosis which is ameliorated by aurintricarboxylic acid. (9425521)
1997
42
Ameliorative effect of MK-801 on retinal ischemia. (9090613)
1997
43
Involvement of adenosine in retinal ischemia. Studies on the rat. (8977474)
1996
44
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
45
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
46
Intraretinal study of cat electroretinogram during retinal ischemia-reperfusion with extracellular K+ concentration microelectrodes. (8113017)
1994
47
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
48
Subretinal neovascular membranes associated with choroidal nonperfusion and retinal ischemia. (2446561)
1987
49
Rod-cone differences in response to retinal ischemia in rabbit. (3803167)
1986
50
Retinal ischemia (capillary nonperfusion) in diabetic retinopathy of patients with and without systemic hypertension. (745825)
1978

Variations for Retinal Ischemia

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Expression for genes affiliated with Retinal Ischemia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for genes affiliated with Retinal Ischemia

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology, 55Reactome, 60Thomson Reuters, 53QIAGEN, 57SinoBiological
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Compounds for genes affiliated with Retinal Ischemia

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Sources:
45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Retinal Ischemia according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1echinomycin459.9SETD2, HIF1A
2deferoxamine mesylate459.9HIF1A, SETD2
3pimonidazole459.9HIF1A, SETD2
4cocl2459.9SETD2, HIF1A
5apigenin45 2910.8SETD2, HIF1A
65-n-ethylcarboxamidoadenosine459.7ADORA1, VEGFA
7su5416459.7VEGFA, HIF1A
8everolimus45 51 1111.7VEGFA, HIF1A
9sunitinib45 51 1111.6VEGFA, HIF1A
10apocynin45 6110.6SETD2, VEGFA
11nickel45 2410.6HIF1A, SETD2
12candesartan45 51 29 1112.6VEGFA, HIF1A
1317-(allylamino)-17-demethoxygeldanamycin459.5HIF1A, SETD2
14deferoxamine45 1110.5SETD2, HIF1A
15verteporfin459.4CASP2, VEGFA
16radicicol45 61 1111.4HIF1A, VEGFA
17gsno459.4HIF1A, SETD2
183-(5-hydroxymethyl-2-furyl)-1-benzylindazole459.3VEGFA, SETD2, HIF1A
19cobalt chloride459.3SETD2, HIF1A, VEGFA
20topotecan45 1110.3SETD2, VEGFA, HIF1A
21diphenyleneiodonium459.3HIF1A, VEGFA, SETD2
22bortezomib45 51 1111.3VEGFA, HIF1A, SETD2
23geldanamycin45 51 61 1112.3HIF1A, VEGFA, SETD2
24n acetylcysteine459.2HIF1A, VEGFA, SETD2
25sb 20358045 6110.2HIF1A, VEGFA, SETD2
26rapamycin459.2HIF1A, VEGFA, SETD2
27phosphoinositide459.2ADORA1, HIF1A, SETD2
28ly294002459.1SETD2, VEGFA, HIF1A
29actinomycin d459.1SETD2, HIF1A, VEGFA
30sp 60012545 6110.1HIF1A, SETD2, CASP2
31camptothecin45 61 1111.1CASP2, HIF1A, SETD2
32etoposide45 51 61 1112.0HIF1A, SETD2, CASP2
33ascorbic acid45 2410.0SETD2, CASP2, HIF1A
34butyrate459.0SETD2, CASP2, HIF1A
35flavopiridol45 119.9CASP2, HIF1A, VEGFA
36wortmannin458.9HIF1A, SETD2, CASP2
37resveratrol45 61 24 1111.9VEGFA, HIF1A, CASP2
38mg 13245 619.9VEGFA, CASP2, HIF1A
395fluorouracil458.9VEGFA, CASP2, HIF1A
40genistein45 29 61 3 24 1113.8VEGFA, ADORA1, HIF1A, SETD2
41estrogen458.7SETD2, ADORA1, HIF1A, VEGFA
42paraffin458.7HIF1A, VEGFA, CASP2
43bapta458.6ADORA1, CASP2, SETD2, HIF1A
44pge2458.6HIF1A, VEGFA, SETD2
45atp45 299.5ADORA1, SETD2, HIF1A, CASP2
46docetaxel45 51 61 1111.5HIF1A, SETD2, CASP2, VEGFA
47arsenite45 249.5CASP2, HIF1A, VEGFA, SETD2
48paclitaxel45 51 1110.5VEGFA, CASP2, SETD2, HIF1A
49doxorubicin45 51 1110.5CASP2, SETD2, VEGFA, HIF1A
50cisplatin45 51 61 1111.5HIF1A, VEGFA, CASP2, SETD2

GO Terms for genes affiliated with Retinal Ischemia

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16Gene Ontology
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Biological processes related to Retinal Ischemia according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614199.6HIF1A, VEGFA
2dopaminergic neuron differentiationGO:0715429.6HIF1A, VEGFA
3positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:0309499.5HIF1A, VEGFA
4positive regulation of neuroblast proliferationGO:0020529.5HIF1A, VEGFA
5regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:0614189.5VEGFA, HIF1A
6outflow tract morphogenesisGO:0031519.4HIF1A, VEGFA
7lactationGO:0075959.4HIF1A, VEGFA
8positive regulation of endothelial cell proliferationGO:0019389.3VEGFA, HIF1A
9cellular response to hypoxiaGO:0714569.2HIF1A, VEGFA
10apoptotic signaling pathwayGO:0971909.1CASP2, ADORA1
11angiogenesisGO:0015259.1VEGFA, HIF1A, SETD2
12response to hypoxiaGO:0016669.1ADORA1, HIF1A, VEGFA
13positive regulation of angiogenesisGO:0457669.0HIF1A, VEGFA

Molecular functions related to Retinal Ischemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein heterodimerization activityGO:0469828.5ADORA1, HIF1A, VEGFA
2protein bindingGO:0055157.5CASP2, ADORA1, SETD2, HIF1A, VEGFA

Products for genes affiliated with Retinal Ischemia

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Sources for Retinal Ischemia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet