Aliases & Classifications for Retinal Ischemia

MalaCards integrated aliases for Retinal Ischemia:

Name: Retinal Ischemia 37 12 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12510
ICD10 32 H35.82
ICD9CM 34 362.84
SNOMED-CT 64 193427006 26468004
UMLS 69 C0162291

Summaries for Retinal Ischemia

MalaCards based summary : Retinal Ischemia is related to eales disease and ischemia. An important gene associated with Retinal Ischemia is HIF1A (Hypoxia Inducible Factor 1 Alpha Subunit), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and retina, and related phenotypes are Increased Nanog expression and Increased Nanog expression

Related Diseases for Retinal Ischemia

Diseases related to Retinal Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 eales disease 29.3 SOD1 TNF VEGFA
2 ischemia 29.0 BCL2 CASP3 CXCL12 HIF1A KNG1 SOD1
3 aging 28.5 BCL2 HIF1A NFKB1 SOD1
4 exudative vitreoretinopathy 1 10.9
5 exudative vitreoretinopathy 2, x-linked 10.9
6 exudative vitreoretinopathy 4 10.9
7 exudative vitreoretinopathy 3 10.9
8 retinitis 10.9
9 age-related hearing loss 10.4 HIF1A SETD2
10 cerebral artery occlusion 10.3 HIF1A TNF
11 intravascular papillary endothelial hyperplasia 10.3 HIF1A VEGFA
12 aids dementia complex 10.2 CXCL12 TNF
13 meningitis and encephalitis 10.2 CAT SOD1
14 critical limb ischemia 10.2 TNF VEGFA
15 neuronitis 10.2
16 endotheliitis 10.1
17 clear cell renal cell carcinoma 10.1 HIF1A SETD2 VEGFA
18 colon adenoma 10.1 CASP3 HIF1A VEGFA
19 dystrophinopathies 10.1 CASP2 TNF
20 retinal hemangioblastoma 10.1 CXCL12 HIF1A VEGFA
21 renal clear cell carcinoma 10.1 HIF1A SETD2 VEGFA
22 helicobacter pylori infection 10.0 CASP3 NFKB1 TNF
23 oral squamous cell carcinoma 10.0 CASP3 HIF1A VEGFA
24 pneumoconiosis 10.0 CAT SOD1 TNF
25 acute vascular insufficiency of intestine 10.0 SOD1 TNF
26 gastrointestinal system cancer 10.0 CASP3 TNF VEGFA
27 kashin-beck disease 10.0 BCL2 TNF
28 microvascular complications of diabetes 5 10.0
29 huntington disease 9.9 CASP2 CASP3 SETD2 SOD1
30 retinal vein occlusion 9.9
31 choroiditis 9.9
32 kidney cancer 9.9 HIF1A SETD2 TNF VEGFA
33 squamous cell carcinoma of the larynx 9.9 BCL2 PCNA
34 limb ischemia 9.9 CXCL12 HIF1A TNF VEGFA
35 neurofibromatosis, type iv, of riccardi 9.8
36 central retinal artery occlusion 9.8
37 retinal artery occlusion 9.8
38 head injury 9.8 BCL2 SOD1
39 primary central nervous system lymphoma 9.8 BCL2 CXCL12
40 arteries, anomalies of 9.8 KNG1 TNF VEGFA
41 esophageal cancer 9.8 CASP3 HIF1A TNF VEGFA
42 temporal arteritis 9.8
43 hydrops, lactic acidosis, and sideroblastic anemia 9.8
44 cataract 9.8
45 neovascular glaucoma 9.8
46 cerebritis 9.8
47 macular retinal edema 9.8
48 ocular hypertension 9.8
49 hypoxia 9.8
50 testicular torsion 9.8 BCL2 PCNA

Comorbidity relations with Retinal Ischemia via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Retinal Ischemia:



Diseases related to Retinal Ischemia

Symptoms & Phenotypes for Retinal Ischemia

GenomeRNAi Phenotypes related to Retinal Ischemia according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased Nanog expression GR00371-A-1 9.9 PCNA CASP2 SETD2 VEGFA
2 Increased Nanog expression GR00371-A-2 9.9 SETD2 VEGFA
3 Increased Nanog expression GR00371-A-4 9.9 SETD2 VEGFA
4 Increased Nanog expression GR00371-A-5 9.9 CASP2 SETD2 VEGFA
5 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 BCL2 PCNA CASP3 SOD1 HIF1A TNF
6 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 NFKB1 BCL2 PCNA CASP3 SOD1 HIF1A
7 Increased cell death HMECs cells GR00103-A-0 9.72 PCNA CASP2 CASP3 CAT HIF1A
8 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.65 PCNA CASP2 CASP3 CAT TNF
9 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.35 NFKB1 BCL2 PCNA SOD1 HIF1A

MGI Mouse Phenotypes related to Retinal Ischemia:

43 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.31 HSPB1 SOD1 NFKB1 HIF1A BCL2 CAT
2 hematopoietic system MP:0005397 10.29 PCNA SETD2 HSPB1 SOD1 NFKB1 BCL2
3 growth/size/body region MP:0005378 10.26 HIF1A PCNA SETD2 HSPB1 KNG1 SOD1
4 cardiovascular system MP:0005385 10.23 HIF1A HSPB1 SETD2 CASP3 BCL2 CXCL12
5 immune system MP:0005387 10.22 PCNA HSPB1 SOD1 NFKB1 HIF1A BCL2
6 endocrine/exocrine gland MP:0005379 10.19 PCNA SOD1 NFKB1 HIF1A CASP3 BCL2
7 homeostasis/metabolism MP:0005376 10.19 NFKB1 HIF1A HSPB1 SETD2 CASP3 CAT
8 mortality/aging MP:0010768 10.18 PCNA SETD2 SOD1 NFKB1 HIF1A CASP3
9 craniofacial MP:0005382 10.1 HIF1A SETD2 NFKB1 CASP3 BCL2 VEGFA
10 digestive/alimentary MP:0005381 10.02 NFKB1 HIF1A CASP3 BCL2 TNF VEGFA
11 integument MP:0010771 10 HIF1A NFKB1 CASP3 BCL2 TNF SOD1
12 muscle MP:0005369 9.97 SOD1 NFKB1 HIF1A CASP3 BCL2 CXCL12
13 nervous system MP:0003631 9.96 HIF1A SETD2 NFKB1 CASP3 BCL2 CXCL12
14 liver/biliary system MP:0005370 9.91 NFKB1 HIF1A CXCL12 TNF SOD1 VEGFA
15 neoplasm MP:0002006 9.8 HIF1A BCL2 CAT SOD1 VEGFA TNF
16 no phenotypic analysis MP:0003012 9.63 PCNA HSPB1 CASP3 CXCL12 TNF VEGFA
17 reproductive system MP:0005389 9.56 PCNA CASP3 BCL2 CXCL12 CASP2 SOD1
18 vision/eye MP:0005391 9.17 HIF1A SETD2 CASP3 BCL2 TNF SOD1

Drugs & Therapeutics for Retinal Ischemia

Drugs for Retinal Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 4 216974-75-3
2
Ranibizumab Approved Phase 4,Phase 1,Phase 2 347396-82-1 459903
3 Antibodies Phase 4
4 Immunoglobulins Phase 4
5 Angiogenesis Inhibitors Phase 4,Phase 1,Phase 2
6 Angiogenesis Modulating Agents Phase 4,Phase 1,Phase 2
7
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
8
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
9 Neurotransmitter Agents Phase 3
10 Platelet Aggregation Inhibitors Phase 3
11 Purinergic P2 Receptor Antagonists Phase 3
12 Purinergic P2Y Receptor Antagonists Phase 3
13
Methylprednisolone Approved, Vet_approved Phase 1, Phase 2 83-43-2 6741
14
Prednisolone Approved, Vet_approved Phase 1, Phase 2 50-24-8 5755
15 Antiemetics Phase 1, Phase 2
16 Anti-Inflammatory Agents Phase 1, Phase 2
17 Autonomic Agents Phase 1, Phase 2
18 Epoetin alfa Phase 1, Phase 2 113427-24-0
19 Gastrointestinal Agents Phase 1, Phase 2
20 glucocorticoids Phase 1, Phase 2
21 Hematinics Phase 1, Phase 2
22 Hormone Antagonists Phase 1, Phase 2
23 Hormones Phase 1, Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1, Phase 2
25 Methylprednisolone acetate Phase 1, Phase 2
26 Methylprednisolone Hemisuccinate Phase 1, Phase 2
27 Neuroprotective Agents Phase 1, Phase 2
28 Peripheral Nervous System Agents Phase 1, Phase 2
29 Prednisolone acetate Phase 1, Phase 2
30 Prednisolone hemisuccinate Phase 1, Phase 2
31 Prednisolone phosphate Phase 1, Phase 2
32 Protective Agents Phase 1, Phase 2
33 Endothelial Growth Factors Phase 1, Phase 2
34 Mitogens Phase 1, Phase 2

Interventional clinical trials:

(show all 23)

# Name Status NCT ID Phase Drugs
1 Laser Therapy Combined With Intravitreal Aflibercept vs Intravitreal Aflibercept Monotherapy (LADAMO) Unknown status NCT02432547 Phase 4 Aflibercept
2 Bevacizumab and Peripheral Retinal Changes on Wide Field Angiography in Diabetic Macular Edema Unknown status NCT02096874 Phase 4 Bevacizumab
3 Long-Term Efficacy & Safety of Aflibercept IVT for the Treatment of DME in Subjects Who Completed the VISTA-DME Trial Completed NCT02299336 Phase 4 Aflibercept
4 Widefield Angiography Guided Targeted-retinal Photocoagulation Combined With Anti VEgf Intravitreal Injections for the Treatment of Ischemic Central Retinal Vein Occlusion, Hemi Retinal Vein Occlusion, and Branch Retinal Vein Occlusion Completed NCT01710839 Phase 4 0.5mg Ranibizumab
5 Evaluation of the Effect of Intravitreal Injections of Anti-VEGF on Macular Perfusion in Diabetic Patients Using OCTA Recruiting NCT03246152 Phase 4 Bevacizumab
6 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion Not yet recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
7 Platelet-Oriented Inhibition in New TIA and Minor Ischemic Stroke (POINT) Trial Active, not recruiting NCT00991029 Phase 3 Clopidogrel;placebo
8 Ranibizumab Supplementing Panretinal Photocoagulation as Treatment for Iris/Angle Neovascularization in Retinal Ischemic Disease Completed NCT00841373 Phase 1, Phase 2
9 Traumatic Optic Neuropathy Treatment Trial (TONTT) Completed NCT01783847 Phase 1, Phase 2 Recombinant human erythropoietin (EPO)
10 Prevention of Retinal Non-perfusion in Central Retinal Vein Occlusion by Hydroxycarbamide Treatment. Recruiting NCT02957760 Phase 2 Hydroxycarbamid
11 Safety and Efficacy of Aflibercept in Proliferative Diabetic Retinopathy. Recruiting NCT02151695 Phase 2 Aflibercept intravitreal injections
12 Study of the Efficacy and Tolerability of Intravitreal Injections of Ranibizumab Compared to Intravitreal Injections of Ranibizumab Combined With Targeted Retinal Photocoagulation to Treat Radiation Retinopathy. Active, not recruiting NCT02222610 Phase 2 0.5 mg ranibizumab
13 Lucentis for New Onset Neovascular Glaucoma Withdrawn NCT00727038 Phase 1, Phase 2 Ranibizumab (Lucentis)
14 Study on the Oxygen Saturation in Pulsating and Non-pulsating Central Retinal Veins Unknown status NCT01794442
15 Retinal Ischemia in Central Retinal Vein Occlusion, and the Effects of Treatment With Intravitreal Ranibizumab Completed NCT01360385
16 Validation of Retinal Oximetry in Glaucoma Patients: a Structural and Functional Correlation Completed NCT01391247
17 Ultra-wide Fluorescein Angiography in Patients With Central Retinal Vein Occlusion Treated by Afilbercept Recruiting NCT02880644
18 Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion Recruiting NCT03061526
19 Rapid, Non-invasive, Regional Functional Imaging of the Retina. (Diabetic Retinopathy Diagnosis Device) Recruiting NCT01546766
20 Correlation Between Macular Ischemia and Peripheral Ischemia in Patients With Diabetes Recruiting NCT02876744
21 Perifoveal Vascular Network Assessed by OCT-Angiography in Type I Diabetes Mellitus Recruiting NCT03422965
22 Pediatric Type 1 Diabetes and Retinopathy Active, not recruiting NCT02691312
23 Radial Optic Neurotomy in Central Retinal Vein Occlusion : a Randomized Trial Terminated NCT00379223

Search NIH Clinical Center for Retinal Ischemia

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Ischemia:
Bone marrow-derived stem cells for retinal diseases
Embryonic/Adult Cultured Cells Related to Retinal Ischemia:
Bone marrow-derived mononuclear cells (family) PMIDs: 23049424 21225138 19347139 23000646

Genetic Tests for Retinal Ischemia

Anatomical Context for Retinal Ischemia

MalaCards organs/tissues related to Retinal Ischemia:

38
Endothelial, Bone, Retina, Eye, Brain, Bone Marrow, Myeloid

Publications for Retinal Ischemia

Articles related to Retinal Ischemia:

(show top 50) (show all 315)
# Title Authors Year
1
Effects of molsidomine on retinal ischemia/reperfusion injury in rabbits. ( 29323543 )
2018
2
PROGRESSION OF RETINAL ISCHEMIA IN A CASE OF MACULAR TELANGIECTASIA TYPE 1 AFTER RANIBIZUMAB INJECTION: OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FINDINGS. ( 29443804 )
2018
3
Vinpocetine protects inner retinal neurons with functional NMDA glutamate receptors against retinal ischemia. ( 29106899 )
2018
4
Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway. ( 29111459 )
2018
5
Use of OCTA, FA, and Ultra-Widefield Imaging in Quantifying Retinal Ischemia: A Review. ( 29436208 )
2018
6
Thrombolyic and Vasodilator Treatment in a Patient With Prolonged Retinal Ischemia. ( 28471897 )
2017
7
Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury. ( 28063877 )
2017
8
Post-ischemic treatment with azithromycin protects ganglion cells against retinal ischemia/reperfusion injury in the rat. ( 29296071 )
2017
9
Resveratrol Ameliorates Retinal Ischemia/Reperfusion Injury in C57BL/6J Mice via Downregulation of Caspase-3. ( 28985092 )
2017
10
Response by Golsari and Thomalla to Letter Regarding Article, "Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study". ( 28626060 )
2017
11
Neurosurgical Modeling of Retinal Ischemia-Reperfusion Injury. ( 29196198 )
2017
12
Application of Arterial Spin Labelling in Detecting Retinal Ischemia. ( 29422857 )
2017
13
Dexmedetomidine preconditioning protects against retinal ischemia/reperfusion injury and inhibits inflammation response via toll-like receptor 4 (TLR4) pathway. ( 28724211 )
2017
14
Neuroprotective effects of a novel peptide, FK18, under oxygen-glucose deprivation in SH-SY5Y cells and retinal ischemia in ratsA viaA the Akt pathway. ( 28257830 )
2017
15
Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study. ( 28386036 )
2017
16
Xue-fu-Zhu-Yu decoction protects rats against retinal ischemia by downregulation of HIF-1I+ and VEGF via inhibition of RBP2 and PKM2. ( 28709426 )
2017
17
Reversibility of retinal ischemia due to central retinal artery occlusion by hyperbaric oxygen. ( 28096655 )
2017
18
Passage through the Ocular Barriers and Beneficial Effects in Retinal Ischemia of Topical Application of PACAP1-38 in Rodents. ( 28335564 )
2017
19
Transplantation of lineage-negative stem cells in pterygopalatine artery ligation induced retinal ischemia-reperfusion injury in mice. ( 28210901 )
2017
20
OCT Angiography: Assessment of Retinal Ischemia in Susac's Syndrome. ( 28613358 )
2017
21
Letter by Kawada Regarding Article, "Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study". ( 28626051 )
2017
22
Protective Effect of Intravitreal Administration of Exosomes Derived from Mesenchymal Stem Cells on Retinal Ischemia. ( 28636406 )
2017
23
Pioglitazone ameliorates retinal ischemia/reperfusion injury<i>via</i>suppressing NLRP3 inflammasome activities. ( 29259897 )
2017
24
Optic Nerve Degeneration after Retinal Ischemia/Reperfusion in a Rodent Model. ( 28878627 )
2017
25
Norrin treatment improves ganglion cell survival in an oxygen-induced retinopathy model of retinal ischemia. ( 28823941 )
2017
26
Curcumin protects against hypertension aggravated retinal ischemia/reperfusion in a rat stroke model. ( 28678631 )
2017
27
Overexpression of Heme Oxygenase-1 in Mesenchymal Stem Cells Augments Their Protection on Retinal Cells In Vitro and Attenuates Retinal Ischemia/Reperfusion Injury In Vivo against Oxidative Stress. ( 28255307 )
2017
28
Bone-marrow mesenchymal stem-cell administration significantly improves outcome after retinal ischemia in rats. ( 28523456 )
2017
29
Chi-Ju-Di-Huang-Wan protects rats against retinal ischemia by downregulating matrix metalloproteinase-9 and inhibiting p38 mitogen-activated protein kinase. ( 27617027 )
2016
30
Peripheral retinal ischemia in a young Indian woman with neurofibromatosis type 1. ( 26949362 )
2016
31
The protective effect of prophylactic ozone administration against retinal ischemia-reperfusion injury. ( 27028056 )
2016
32
Involvement of microRNA-181a and Bim in a rat model of retinal ischemia-reperfusion injury. ( 26949607 )
2016
33
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury. ( 27008854 )
2016
34
Cellular Stress Response and Immune Signaling in Retinal Ischemia-Reperfusion Injury. ( 27822213 )
2016
35
Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury. ( 27185592 )
2016
36
Utility of optical coherence tomography in the evaluation of monocular visual loss related to retinal ischemia. ( 26765759 )
2016
37
Lower Hemoglobin Concentration Is Associated with Retinal Ischemia and the Severity of Diabetic Retinopathy in Type 2 Diabetes. ( 27200379 )
2016
38
Cryopreserved Mesenchymal Stromal Cells Maintain Potency in a Retinal Ischemia/Reperfusion Injury Model: Toward an off-the-shelf Therapy. ( 27212469 )
2016
39
Methane attenuates retinal ischemia/reperfusion injury via anti-oxidative and anti-apoptotic pathways. ( 27208496 )
2016
40
Inhibiting Matrix Metalloproteinase 3 Ameliorates Neuronal Loss in the Ganglion Cell Layer of Rats in Retinal Ischemia/Reperfusion. ( 26830289 )
2016
41
Pre-treatment with vinpocetine protects against retinal ischemia. ( 27899287 )
2016
42
Cannabinoid receptors and TRPA1 on neuroprotection in a model of retinal ischemia. ( 27876485 )
2016
43
A Mouse Model of Retinal Ischemia-Reperfusion Injury Through Elevation of Intraocular Pressure. ( 27501124 )
2016
44
Refractory acute angle-closure glaucoma with retinal ischemia: January consultation #1. ( 26948794 )
2016
45
Functional and Structural Evaluation of Sildenafil in a Rat Model of Acute Retinal Ischemia/Reperfusion Injury. ( 27421045 )
2016
46
Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. ( 27158842 )
2016
47
Neuroprotective impact of prothymosin alpha-derived hexapeptide against retinal ischemia-reperfusion. ( 26779836 )
2016
48
Postconditioning with inhaled hydrogen promotes survival of retinal ganglion cells in a rat model of retinal ischemia/reperfusion injury. ( 26705611 )
2016
49
Hypoxic-Preconditioned Bone Marrow Stem Cell Medium Significantly Improves Outcome After Retinal Ischemia in Rats. ( 27367588 )
2016
50
Protective effect of etanercept, an inhibitor of tumor necrosis factor-I+, in a rat model of retinal ischemia. ( 27259948 )
2016

Variations for Retinal Ischemia

Expression for Retinal Ischemia

Search GEO for disease gene expression data for Retinal Ischemia.

Pathways for Retinal Ischemia

Pathways related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.62 BCL2 CASP2 CASP3 CXCL12 NFKB1 TNF
2
Show member pathways
13.32 BCL2 CASP3 HIF1A NFKB1 TNF VEGFA
3
Show member pathways
13.26 BCL2 CASP2 CASP3 CXCL12 NFKB1 TNF
4
Show member pathways
13.01 BCL2 CASP3 NFKB1 PCNA VEGFA
5
Show member pathways
12.94 BCL2 CASP3 NFKB1 TNF VEGFA
6
Show member pathways
12.85 BCL2 CASP2 CASP3 NFKB1 TNF
7
Show member pathways
12.84 CASP2 CASP3 CXCL12 NFKB1 TNF
8 12.76 BCL2 CASP3 CXCL12 HIF1A NFKB1 VEGFA
9
Show member pathways
12.69 BCL2 CASP2 CASP3 HSPB1 NFKB1 TNF
10 12.6 CASP2 CASP3 HSPB1 NFKB1 TNF VEGFA
11
Show member pathways
12.56 BCL2 HIF1A NFKB1 TNF
12
Show member pathways
12.56 HSPB1 NFKB1 TNF VEGFA
13 12.49 BCL2 CASP3 NFKB1 VEGFA
14
Show member pathways
12.47 CASP2 CASP3 NFKB1 TNF
15
Show member pathways
12.44 BCL2 CASP2 CASP3 NFKB1 TNF VEGFA
16
Show member pathways
12.31 CAT NFKB1 SOD1 TNF
17 12.27 CASP3 HIF1A TNF VEGFA
18
Show member pathways
12.24 CASP3 HIF1A NFKB1 VEGFA
19
Show member pathways
12.23 BCL2 CASP2 CASP3 HIF1A
20
Show member pathways
12.22 BCL2 CASP3 NFKB1 TNF
21 12.21 BCL2 CASP2 CASP3 TNF
22 12.19 BCL2 CASP3 NFKB1 TNF
23
Show member pathways
12.15 BCL2 CASP2 CASP3 HSPB1 TNF
24 12.13 CASP3 NFKB1 TNF VEGFA
25
Show member pathways
12.09 CASP2 CASP3 NFKB1 TNF
26 12.09 BCL2 CASP3 NFKB1 VEGFA
27 12.07 BCL2 CASP2 CASP3
28 12.04 BCL2 NFKB1 TNF VEGFA
29 12.01 BCL2 HSPB1 NFKB1 VEGFA
30 11.98 BCL2 NFKB1 TNF
31 11.98 CASP3 HIF1A NFKB1 TNF VEGFA
32 11.96 BCL2 CAT NFKB1
33 11.93 CASP3 NFKB1 TNF
34 11.93 BCL2 HIF1A TNF VEGFA
35 11.86 BCL2 CASP3 NFKB1
36 11.85 BCL2 CASP3 NFKB1
37
Show member pathways
11.85 HIF1A HSPB1 VEGFA
38 11.85 BCL2 HIF1A NFKB1 VEGFA
39 11.83 CXCL12 TNF VEGFA
40 11.82 CASP3 HSPB1 NFKB1 TNF
41 11.8 BCL2 CXCL12 NFKB1 TNF
42
Show member pathways
11.79 CASP3 CXCL12 NFKB1
43 11.75 CASP3 NFKB1 TNF
44
Show member pathways
11.74 BCL2 CASP2 CASP3 NFKB1 TNF
45
Show member pathways
11.73 BCL2 NFKB1 TNF
46
Show member pathways
11.7 BCL2 CASP2 CASP3 NFKB1
47
Show member pathways
11.69 BCL2 CASP3 HIF1A NFKB1 PCNA TNF
48 11.67 CXCL12 HIF1A VEGFA
49
Show member pathways
11.65 NFKB1 TNF VEGFA
50
Show member pathways
11.61 BCL2 CASP3 CAT SOD1 TNF

GO Terms for Retinal Ischemia

Cellular components related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CAT CXCL12 HSPB1 KNG1 SOD1 TNF
2 axon cytoplasm GO:1904115 8.8 HIF1A HSPB1 SOD1

Biological processes related to Retinal Ischemia according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.93 BCL2 CASP3 CAT SOD1
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 CAT NFKB1 TNF
3 positive regulation of angiogenesis GO:0045766 9.86 HIF1A HSPB1 VEGFA
4 negative regulation of neuron apoptotic process GO:0043524 9.86 BCL2 HIF1A SOD1
5 platelet degranulation GO:0002576 9.84 KNG1 SOD1 VEGFA
6 negative regulation of gene expression GO:0010629 9.84 HIF1A NFKB1 TNF VEGFA
7 response to virus GO:0009615 9.82 CXCL12 HSPB1 TNF
8 cellular response to hypoxia GO:0071456 9.82 BCL2 HIF1A VEGFA
9 kidney development GO:0001822 9.81 BCL2 CAT VEGFA
10 positive regulation of apoptotic process GO:0043065 9.8 CASP2 CASP3 KNG1 SOD1 TNF
11 response to estradiol GO:0032355 9.79 CASP3 CAT PCNA
12 response to organic substance GO:0010033 9.78 CASP3 SOD1 TNF
13 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.77 CASP2 CASP3 TNF
14 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.77 BCL2 TNF VEGFA
15 apoptotic signaling pathway GO:0097190 9.76 CASP2 CASP3 TNF
16 positive regulation of endothelial cell proliferation GO:0001938 9.74 CXCL12 HIF1A VEGFA
17 response to glucocorticoid GO:0051384 9.72 BCL2 CASP3 TNF
18 negative regulation of ossification GO:0030279 9.69 BCL2 HIF1A
19 camera-type eye morphogenesis GO:0048593 9.69 HIF1A VEGFA
20 B cell homeostasis GO:0001782 9.69 BCL2 CASP3
21 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.69 BCL2 CASP2 TNF
22 response to iron ion GO:0010039 9.68 BCL2 HIF1A
23 positive regulation of neuroblast proliferation GO:0002052 9.68 HIF1A VEGFA
24 positive regulation of chemokine production GO:0032722 9.67 HIF1A TNF
25 negative regulation of apoptotic signaling pathway GO:2001234 9.67 BCL2 HSPB1
26 muscle cell cellular homeostasis GO:0046716 9.67 HIF1A SOD1
27 positive regulation of cell adhesion GO:0045785 9.67 CXCL12 TNF VEGFA
28 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.66 HIF1A VEGFA
29 digestive tract morphogenesis GO:0048546 9.65 BCL2 HIF1A
30 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.65 HSPB1 TNF
31 induction of positive chemotaxis GO:0050930 9.64 CXCL12 VEGFA
32 ovarian follicle development GO:0001541 9.63 BCL2 SOD1 VEGFA
33 growth GO:0040007 9.62 BCL2 VEGFA
34 response to reactive oxygen species GO:0000302 9.62 CAT SOD1
35 response to oxidative stress GO:0006979 9.62 BCL2 CAT PCNA SOD1
36 response to radiation GO:0009314 9.61 BCL2 CAT CXCL12
37 cellular response to nicotine GO:0071316 9.58 NFKB1 TNF
38 positive regulation of axon extension involved in axon guidance GO:0048842 9.56 CXCL12 VEGFA
39 response to hypoxia GO:0001666 9.55 CASP3 CAT CXCL12 HIF1A VEGFA
40 positive regulation of blood vessel endothelial cell migration GO:0043536 9.54 HIF1A HSPB1 VEGFA
41 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.52 HSPB1 VEGFA
42 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.48 HIF1A VEGFA
43 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 BCL2 CASP2 CASP3
44 negative regulation of apoptotic process GO:0043066 9.28 BCL2 CASP2 CASP3 CAT HIF1A HSPB1
45 response to hydrogen peroxide GO:0042542 9.26 BCL2 CASP3 CAT SOD1

Molecular functions related to Retinal Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.63 BCL2 CAT HSPB1 NFKB1 SOD1 VEGFA
2 protease binding GO:0002020 9.54 BCL2 CASP3 TNF
3 enzyme binding GO:0019899 9.35 CASP2 CAT HIF1A PCNA SOD1
4 cysteine-type endopeptidase activity involved in execution phase of apoptosis GO:0097200 9.32 CASP2 CASP3
5 cysteine-type endopeptidase activity involved in apoptotic process GO:0097153 9.26 CASP2 CASP3
6 identical protein binding GO:0042802 9.23 BCL2 CASP2 HSPB1 NFKB1 PCNA SOD1

Sources for Retinal Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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