MCID: RTN020
MIFTS: 46

Retinal Vascular Disease

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vascular Disease

MalaCards integrated aliases for Retinal Vascular Disease:

Name: Retinal Vascular Disease 12 14
Retinal Vascular 51 69
Retina Circulation Disorder 12
Retinal Vascular Disorder 69

Classifications:



External Ids:

Disease Ontology 12 DOID:2462
NCIt 46 C35170
SNOMED-CT 64 57534004

Summaries for Retinal Vascular Disease

MalaCards based summary : Retinal Vascular Disease, also known as retinal vascular, is related to retinal vascular occlusion and exudative vitreoretinopathy, and has symptoms including chest pain An important gene associated with Retinal Vascular Disease is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are mTOR signaling pathway (KEGG) and Selenium Micronutrient Network. The drugs Bevacizumab and Ranibizumab have been mentioned in the context of this disorder. Affiliated tissues include retina, endothelial and eye, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Retinal Vascular Disease

Diseases related to Retinal Vascular Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 34.3 MTHFR PLG VEGFA
2 exudative vitreoretinopathy 31.0 FZD4 LRP5 NDP TSPAN12 ZNF408
3 retinal vein occlusion 30.1 MTHFR SERPINF1 VEGFA
4 microvascular complications of diabetes 5 28.6 AKR1B1 ALB FLT1 ICAM1 INS KDR
5 retinal degeneration 11.0
6 hemifacial spasm 10.5 MTHFR VEGFA
7 diabetic cataract 10.5 AKR1B1 SERPINF1 VEGFA
8 leukocoria 10.5 FZD4 NDP
9 central retinal vein occlusion 10.5 MTHFR SERPINF1 VEGFA
10 vascular disease 10.5
11 retinitis 10.5
12 kuhnt-junius degeneration 10.5 KDR PLG VEGFA
13 lymphangioma 10.5 KDR SERPINF1 VEGFA
14 severe nonproliferative diabetic retinopathy 10.4 INS VEGFA
15 retinal telangiectasia 10.4 FZD4 NDP TSPAN12
16 vitreous disease 10.4 CTGF PLG VEGFA
17 degeneration of macula and posterior pole 10.4 KDR PLG VEGFA
18 macular retinal edema 10.4 ICAM1 SERPINF1 VEGFA
19 hypoglycemic coma 10.4 INS VEGFA
20 endophthalmitis 10.4 ICAM1 PLG VEGFA
21 leukostasis 10.4 ICAM1 KDR VEGFA
22 background diabetic retinopathy 10.4 ALB INS VEGFA
23 hepatic vascular disease 10.4 ALB MTHFR PLG
24 diabetic macular edema 10.4 ICAM1 SERPINF1 VEGFA
25 vitreous detachment 10.4 PLG VEGFA
26 vein disease 10.4 ALB MTHFR PLG
27 diabetic neuropathy 10.4 AKR1B1 INS VEGFA
28 ovarian hyperstimulation syndrome 10.4 ALB KDR VEGFA
29 angiokeratoma circumscriptum 10.3 FLT1 KDR VEGFA
30 capillary hemangioma 10.3 FLT1 KDR VEGFA
31 epithelioid hemangioendothelioma 10.3 FLT1 KDR VEGFA
32 osteoporosis-pseudoglioma syndrome 10.3 FZD4 LRP5 NDP
33 autonomic neuropathy 10.3 AKR1B1 ALB INS
34 idiopathic interstitial pneumonia 10.3 CTGF ICAM1 VEGFA
35 vascular cancer 10.3 FLT1 KDR VEGFA
36 placental insufficiency 10.3 FLT1 KDR VEGFA
37 glomeruloid hemangioma 10.3 FLT1 VEGFA
38 angiosarcoma 10.3 FLT1 KDR VEGFA
39 urinary system disease 10.3 ALB CTGF INS
40 microvascular complications of diabetes 3 10.2 AKR1B1 ALB CTGF INS
41 glucose metabolism disease 10.2 ALB INS PSMD9
42 acquired metabolic disease 10.2 ALB INS PSMD9
43 hemangioendothelioma 10.2 KDR PLG
44 pregnancy loss, recurrent 1 10.2 LIF MTHFR
45 sialolithiasis 10.2 ALB CTGF LRP5
46 coats disease 10.2 FZD4 KDR NDP TSPAN12 VEGFA
47 norrie disease 10.2 FZD4 LRP5 NDP TSPAN12
48 eclampsia 10.2 ALB FLT1 MTHFR
49 acute hemorrhagic leukoencephalitis 10.1 FLT1 KDR OCLN VEGFA
50 breast carcinoma in situ 10.1 FLT1 KDR LIF VEGFA

Graphical network of the top 20 diseases related to Retinal Vascular Disease:



Diseases related to Retinal Vascular Disease

Symptoms & Phenotypes for Retinal Vascular Disease

UMLS symptoms related to Retinal Vascular Disease:


chest pain

MGI Mouse Phenotypes related to Retinal Vascular Disease:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.37 INS LIF KDR LRP5 FLT1 FZD4
2 homeostasis/metabolism MP:0005376 10.32 INS LIF KDR ICAM1 FLT1 AKR1B1
3 growth/size/body region MP:0005378 10.31 INS LIF KDR ICAM1 FLT1 AKR1B1
4 cellular MP:0005384 10.29 KDR ICAM1 INS LIF FLT1 ALB
5 endocrine/exocrine gland MP:0005379 10.25 INS LIF LRP5 ICAM1 ALB FZD4
6 digestive/alimentary MP:0005381 10.24 INS LIF ALB FZD4 CTGF ICAM1
7 immune system MP:0005387 10.2 KDR ICAM1 INS LIF FLT1 SERPINF1
8 mortality/aging MP:0010768 10.18 KDR ICAM1 INS LIF FLT1 AKR1B1
9 embryo MP:0005380 10.13 KDR INS LIF FLT1 FZD4 CTGF
10 nervous system MP:0003631 10.1 INS LIF KDR LRP5 FLT1 AIPL1
11 integument MP:0010771 10.09 INS LIF KDR ICAM1 FZD4 CTGF
12 liver/biliary system MP:0005370 10.01 INS LIF KDR ALB CTGF LRP5
13 muscle MP:0005369 9.97 INS LIF KDR ICAM1 FLT1 ALB
14 reproductive system MP:0005389 9.85 INS LIF FLT1 FZD4 OCLN PLG
15 skeleton MP:0005390 9.7 INS LIF KDR LRP5 AKR1B1 CTGF
16 vision/eye MP:0005391 9.53 INS LIF KDR LRP5 FLT1 AIPL1

Drugs & Therapeutics for Retinal Vascular Disease

Drugs for Retinal Vascular Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3 216974-75-3
2
Ranibizumab Approved Phase 3 347396-82-1 459903
3 Angiogenesis Inhibitors Phase 3
4 Angiogenesis Modulating Agents Phase 3
5 Endothelial Growth Factors Phase 3
6 Mitogens Phase 3
7
Adenosine Approved, Investigational Phase 2 58-61-7 60961
8
Regadenoson Approved, Investigational Phase 2 313348-27-5 219024
9 Neurotransmitter Agents Phase 2
10
Dipivefrin Approved 52365-63-6 3105
11
Triamcinolone Approved, Vet_approved 124-94-7 31307
12 Anesthetics
13 Anti-Inflammatory Agents
14 glucocorticoids
15 Hormone Antagonists
16 Hormones
17 Hormones, Hormone Substitutes, and Hormone Antagonists
18 Immunosuppressive Agents
19 Proxymetacaine
20 triamcinolone acetonide
21 Triamcinolone diacetate
22 Triamcinolone hexacetonide
23 Pharmaceutical Solutions

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective Trial of Treat and Extend Aflibercept for Macular Edema Secondary to Branch Retinal Vein Occlusion Not yet recruiting NCT03405376 Phase 4 Intravitreal aflibercept injection
2 Long-term Treatment Effect of Intravitreal Ant-VEGF in Branch Retinal Vein Occlusion Completed NCT02033031 Phase 3 Lucentis intravitreal injection;Avastin intravitreal injection
3 The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo Recruiting NCT03090087 Phase 2 Regadenoson
4 Study to Assess the Safety and Tolerability of a Single Administration of FOV2302 (Ecallantide) in Patients With Macular Edema Associated With Central Retinal Vein Occlusion Terminated NCT00969293 Phase 1 FOV2302 (Ecallantide)
5 Comparison of Two Techniques for Epiretinal or Internal Limiting Membrane Peel Unknown status NCT00892619
6 Sheathotomy vs. Intravitreal Triamcinolone for Branch Retinal Vein Occlusion Completed NCT00612261
7 Morphologic Changes After Membrane Peeling With Air Tamponade and Balanced Salt Solution Completed NCT02319655
8 Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics Recruiting NCT01994174
9 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196

Search NIH Clinical Center for Retinal Vascular Disease

Genetic Tests for Retinal Vascular Disease

Anatomical Context for Retinal Vascular Disease

MalaCards organs/tissues related to Retinal Vascular Disease:

38
Retina, Endothelial, Eye

Publications for Retinal Vascular Disease

Articles related to Retinal Vascular Disease:

(show top 50) (show all 65)
# Title Authors Year
1
Microscope-Integrated Optical Coherence Tomography Angiography in the Operating Room in Young Children With Retinal Vascular Disease. ( 28384676 )
2017
2
Ischemic Retinal Vascular Disease in an Infant With Hemophagocytic Lymphohistiocytosis. ( 28983568 )
2017
3
TESTOSTERONE SUPPLEMENTATION AND RETINAL VASCULAR DISEASE. ( 29040227 )
2017
4
Do photoreceptor cells cause the development of retinal vascular disease? ( 28438678 )
2017
5
Cell Therapy Applications for Retinal Vascular Diseases: Diabetic Retinopathy and Retinal Vein Occlusion. ( 27116667 )
2016
6
Adult lead exposure increases blood-retinal permeability: A risk factor for retinal vascular disease. ( 27663850 )
2016
7
Nanoengineering of therapeutics for retinal vascular disease. ( 26022642 )
2015
8
Systemic atheromatosis influence on retinal vascular disease. ( 25729610 )
2014
9
Changes in the foveal microstructure after intravitreal bevacizumab application in patients with retinal vascular disease. ( 23355773 )
2013
10
Regional morphology and pathophysiology of retinal vascular disease. ( 23892140 )
2013
11
[Cytokine determination from vitreous samples in retinal vascular diseases]. ( 23224211 )
2013
12
The role of glia in retinal vascular disease. ( 22519424 )
2012
13
Macular ischaemia: a contraindication for anti-VEGF treatment in retinal vascular disease? ( 22250209 )
2012
14
Retinal vascular disease and the pathogenesis of facioscapulohumeral muscular dystrophy. A signalling message from Wnt? ( 21377364 )
2011
15
The multifactorial nature of retinal vascular disease. ( 20714177 )
2010
16
Molecular targets for retinal vascular diseases. ( 17133346 )
2007
17
[Aging and retinal vascular diseases]. ( 17402563 )
2007
18
Newly recognized serous macular detachment in retinal vascular disease. ( 16770254 )
2006
19
Retinal vascular disease in hypertension. Risk factor modification optimizes vision outcomes. ( 16001767 )
2005
20
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects. ( 12356186 )
2002
21
Plasma total homocysteine and retinal vascular disease. ( 11040905 )
2000
22
Association of antiphospholipid antibodies with retinal vascular disease in systemic lupus erythematosus. ( 10342390 )
1999
23
Ambulatory blood pressure monitoring in cerebrovascular and retinal vascular disease. ( 17895027 )
1997
24
Ambulatory blood pressure monitoring in cerebrovascular and retinal vascular disease. ( 17895021 )
1997
25
Antiphospholipid antibodies and retinal vascular disease. ( 8869905 )
1996
26
On the significance of retinal vascular disease and hearing loss in facioscapulohumeral muscular dystrophy. ( 7739630 )
1995
27
On the significance of retinal vascular disease and hearing loss in facioscapulohumeral muscular dystrophy. ( 23573590 )
1995
28
Retinal vascular disease in ulcerative colitis. ( 8085600 )
1994
29
Arnall Patz Medal for Excellence in Retinal Vascular Disease. Matthew D. Davis, MD. ( 1439249 )
1992
30
Cerebral ischemic events associated with endocarditis, retinal vascular disease, and lupus anticoagulant. ( 1900660 )
1991
31
Semiconductor diode laser photocoagulation in retinal vascular disease. ( 2255529 )
1990
32
Crohn's disease and retinal vascular disease. ( 2220968 )
1990
33
The patency of the retinal vasculature to erythrocytes in retinal vascular disease. ( 2318585 )
1990
34
Antiphospholipid antibodies associated with retinal vascular disease. ( 2133045 )
1990
35
Occlusive retinal vascular disease in two patients. ( 2788911 )
1989
36
Initial clinical experience using a diode laser in the treatment of retinal vascular disease. ( 2630328 )
1989
37
The tunable dye laser in the management of retinal vascular disease. ( 3229908 )
1988
38
Antiphospholipid antibodies associated with retinal vascular disease. ( 3124231 )
1987
39
The eyes of Woodrow Wilson. Retinal vascular disease and George de Schweinitz. ( 3887267 )
1985
40
Occlusive retinal vascular disease in systemic lupus erythematosus. ( 6084063 )
1984
41
Treatment of retinal vascular disease using photocoagulation and cryotherapy. ( 6676223 )
1983
42
Digital subtraction angiography in the diagnosis of retinal vascular disease. ( 6195923 )
1983
43
Selected molecular weight dextrans for in vivo permeability studies of rat retinal vascular disease. ( 872904 )
1977
44
Retinal vascular disease: introduction and phenomenology. ( 888253 )
1977
45
Photocoagulation in retinal vascular disease. ( 281780 )
1977
46
Symposium on retinal vascular disease. Conclusion. ( 1070875 )
1976
47
Occlusive retinal vascular disease and deafness. ( 949074 )
1976
48
Clinical understanding in the management of retinal vascular disease. ( 1070871 )
1976
49
Retinal vascular disease. ( 4415614 )
1974
50
Evolution of hypertensive retinal vascular disease: correlation between clinical and postmortem observations. ( 4748590 )
1973

Variations for Retinal Vascular Disease

Expression for Retinal Vascular Disease

Search GEO for disease gene expression data for Retinal Vascular Disease.

Pathways for Retinal Vascular Disease

GO Terms for Retinal Vascular Disease

Cellular components related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 ALB CTGF FLT1 INS KDR LIF
2 extracellular space GO:0005615 9.36 AKR1B1 ALB CTGF FLT1 ICAM1 INS
3 platelet alpha granule lumen GO:0031093 9.33 ALB PLG VEGFA

Biological processes related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.98 CTGF INS LIF NDP VEGFA
2 negative regulation of gene expression GO:0010629 9.88 CTGF KDR SERPINF1 VEGFA
3 positive regulation of cell migration GO:0030335 9.83 FLT1 INS KDR VEGFA
4 lung development GO:0030324 9.79 CTGF LIF VEGFA
5 canonical Wnt signaling pathway GO:0060070 9.77 FZD4 LRP5 NDP
6 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.74 FLT1 KDR VEGFA
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.72 FLT1 INS KDR
8 angiogenesis GO:0001525 9.72 CTGF FLT1 KDR TSPAN12 VEGFA
9 positive regulation of cell proliferation GO:0008284 9.7 CTGF FLT1 INS KDR LIF LRP5
10 vasculogenesis GO:0001570 9.69 FZD4 KDR VEGFA
11 positive regulation of MAPK cascade GO:0043410 9.67 FLT1 INS KDR LIF
12 negative regulation of cell-substrate adhesion GO:0010812 9.63 FZD4 PLG
13 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.62 FLT1 VEGFA
14 cell migration involved in sprouting angiogenesis GO:0002042 9.62 KDR VEGFA
15 response to amino acid GO:0043200 9.61 CTGF ICAM1 MTHFR
16 positive regulation of positive chemotaxis GO:0050927 9.6 KDR VEGFA
17 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 FLT1 KDR VEGFA
18 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.56 ICAM1 INS LIF VEGFA
19 vascular endothelial growth factor signaling pathway GO:0038084 9.54 FLT1 KDR
20 regulation of cGMP metabolic process GO:0030823 9.49 AIPL1 VEGFA
21 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 9.48 KDR VEGFA
22 retinal blood vessel morphogenesis GO:0061304 9.46 FZD4 LRP5
23 retina vasculature morphogenesis in camera-type eye GO:0061299 9.13 FZD4 LRP5 NDP
24 extracellular matrix-cell signaling GO:0035426 8.8 FZD4 LRP5 NDP
25 multicellular organism development GO:0007275 10.1 FLT1 FZD4 KDR LIF LRP5 SERPINF1
26 negative regulation of apoptotic process GO:0043066 10 AIPL1 AKR1B1 ALB KDR VEGFA

Molecular functions related to Retinal Vascular Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 AIPL1 ALB CTGF FLT1 FZD4 ICAM1
2 growth factor activity GO:0008083 9.46 CTGF LIF NDP VEGFA
3 vascular endothelial growth factor-activated receptor activity GO:0005021 9.26 FLT1 KDR
4 Wnt-activated receptor activity GO:0042813 8.8 FZD4 LRP5 TSPAN12

Sources for Retinal Vascular Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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