MCID: RTN021
MIFTS: 42

Retinal Vascular Occlusion malady

Eye category

Summaries for Retinal Vascular Occlusion

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Vascular Occlusion, also known as retinal vascular occlusion, unspecified, is related to vascular disease and central retinal vein occlusion. An important gene associated with Retinal Vascular Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Common Pathway. The compounds phosphatidylserine and uric acid have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Retinal Vascular Occlusion

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 40NCIt, 57SNOMED-CT, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

retinal vascular occlusion 8 45 61
retinal vascular occlusion, unspecified 8
unspecified retinal vascular occlusion 8
retinal vascular occlusion nos 8
cardiovascular occlusion 61
retinal vasc. occlusion 8


External Ids:

Disease Ontology8 DOID:1729
ICD9CM27 362.30, 362.3
NCIt40 C34980
ICD1025 H34

Related Diseases for Retinal Vascular Occlusion

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1vascular disease30.6APOH, VEGFA, SELP, SERPINC1
2central retinal vein occlusion30.5VEGFA, MTHFR, F5, APOH
3thrombophilia30.5APOH, F5, MTHFR, SELP, SERPINC1
4branch retinal artery occlusion30.2F5
5hemoglobinuria30.2PIGA
6blindness30.1VEGFA, RHO
7atherosclerosis30.1APOH, MTHFR, SELP, SERPINC1
8antiphospholipid syndrome30.1APOH, F5, MTHFR, SELP, SERPINC1
9central retinal artery occlusion10.4
10neurofibromatosis10.1
11traumatic glaucoma10.1
12exfoliation syndrome10.1
13ischemic neuropathy10.1
14retinitis pigmentosa10.1
15thrombotic thrombocytopenic purpura10.1
16ischemic optic neuropathy10.1
17paroxysmal nocturnal hemoglobinuria10.1
18occlusion of gallbladder10.0
19patent foramen ovale10.0F5
20thrombophlebitis10.0APOH
21retinal artery occlusion10.0APOH
22deficiency anemia10.0PIGA
23hepatic vein thrombosis10.0PIGA
24quebec platelet disorder10.0F5
25retinitis10.0RHO
26splenic infarction10.0APOH
27autoimmune hemolytic anemia10.0PIGA
28chagas disease10.0RHO
29cystic fibrosis10.0RHO
30essential hypertension10.0SELP
31myeloma10.0VEGFA
32kidney cancer10.0VEGFA
33sickle cell disease10.0SELP
34intermittent claudication10.0SELP
35carotid stenosis10.0SELP
36hypercholesterolemia10.0SELP
37purpura10.0SERPINC1
38nephrotic syndrome10.0SERPINC1
39polycythemia vera10.0SELP
40uveitis10.0RHO
41liver cirrhosis10.0SERPINC1
42endometriosis10.0VEGFA
43lung cancer10.0VEGFA
44endophthalmitis10.0VEGFA
45peritonitis10.0SELP
46psoriasis10.0SELP
47mondor disease10.0F5, APOH
48coronary thrombosis10.0SERPINC1
49pancreatitis10.0SELP
50ovarian hyperstimulation syndrome10.0VEGFA, F5

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to retinal vascular occlusion

Clinical Features for Retinal Vascular Occlusion

Drugs & Therapeutics for Retinal Vascular Occlusion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Retinal Vascular Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vascular Occlusion

Search NIH Clinical Center for Retinal Vascular Occlusion

Search CenterWatch for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

Anatomical Context for Retinal Vascular Occlusion

Animal Models for Retinal Vascular Occlusion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9RHO
2MP:00053859.5RHO, SELP
3MP:00107719.2VEGFA, PIGA
4MP:00036316.9MTHFR, PIGA, F5, RHO, VEGFA, SELP
5MP:00053766.9MTHFR, RHO, VEGFA, SELP, SERPINC1, APOH
6MP:00107686.9SERPINC1, SELP, VEGFA, MTHFR, F5, APOH

Publications for Retinal Vascular Occlusion

Sources:
51PubMed
See all sources

Articles related to Retinal Vascular Occlusion:

(show top 50)    (show all 109)
idTitleAuthorsYear
1
Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion. (23260261)
2013
2
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. (23869159)
2013
3
Pipeline embolization device: a new source for embolic retinal vascular occlusion. (24051422)
2013
4
Vascular remodeling in central retinal vein occlusion following laser-induced chorioretinal anastomosis. (23494049)
2013
5
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. (24034133)
2013
6
Anti-vascular endothelial growth factors in the treatment of macular oedema secondary to central retinal vein occlusion: a meta-analysis. (24330277)
2013
7
Thrombophilia and retinal vascular occlusion. (22969282)
2012
8
Effect of intravitreal anti-vascular endothelial growth factor treatment on the retinal gene expression in acute experimental central retinal vein occlusion. (22116547)
2012
9
Vascular endothelial growth factor and interleukin-6 are correlated with serous retinal detachment in central retinal vein occlusion. (21978265)
2012
10
Usefulness of indocyanine green angiography to depict the distant retinal vascular anomalies associated with branch retinal vein occlusion causing serous macular detachment. (21869614)
2012
11
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
12
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
13
Role of soluble vascular endothelial growth factor receptor-2 in macular oedema with central retinal vein occlusion. (21109696)
2011
14
Significant correlation between electroretinogram parameters and ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes. (21642626)
2011
15
Macular ischaemia after intravitreal bevacizumab injection in patients with central retinal vein occlusion and a history of diabetes and vascular disease. (20215378)
2010
16
Factor V Leiden mutation with retinal vascular occlusion. (21199226)
2010
17
Long-term study of vascular perfusion effects following arteriovenous sheathotomy for branch retinal vein occlusion. (20222903)
2010
18
Increase of vascular endothelial growth factor and interleukin-6 in the aqueous humour of patients with macular oedema and central retinal vein occlusion. (19563372)
2010
19
Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion. (20927757)
2010
20
Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome. (19557023)
2010
21
Retinal vascular occlusion syndromes. (19584622)
2009
22
Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (19118700)
2009
23
Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions. (18160589)
2008
24
Primary vascular occlusion in IRVAN (idiopathic retinal vasculitis, aneurysms, neuroretinitis) syndrome. (16766406)
2006
25
Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. (16133018)
2006
26
Inappropriate investigation and management of a retinal vascular occlusion. (16082396)
2006
27
Retinal vascular occlusion following ocular contusion. (15931542)
2005
28
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. (15710833)
2005
29
Retinal vascular occlusion in patients infected with human immunodeficiency virus. (16141865)
2005
30
The characteristics of retinitis pigmentosa with retinal vascular occlusion]. (15938805)
2005
31
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. (12881356)
2003
32
Thrombophilia factors as inducers of retinal vascular occlusion]. (11450475)
2001
33
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653431)
2000
34
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653432)
2000
35
Retinal vascular occlusion and deficiencies in the protein C pathway. (10482096)
1999
36
Delayed diagnosis of homocystinuria as a cause of vascular retinal occlusion in young adults. (10610111)
1999
37
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. (9152086)
1997
38
Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. (8002838)
1994
39
Retinal vascular occlusion without retrobulbar or optic nerve sheath hemorrhage after retrobulbar injection of lidocaine. (3231409)
1988
40
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. (3721722)
1986
41
Retinal vascular occlusion. (7013655)
1981
42
Retinal vascular occlusion and thrombocyte aggregation. (6931872)
1980
43
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978
44
Central retinal vascular occlusion associated with oral contraceptives. (736077)
1978
45
Ocular hypotony after retinal vascular occlusion. (281809)
1977
46
Abnormal glucose tolerance in association with retinal vascular occlusion. (4752297)
1973
47
Retinal vascular occlusion as a presenting feature of glaucoma simplex. (5575222)
1971
48
Fluorescein studies in retinal vascular occlusion. (5635899)
1968
49
A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. VI. X-ray irradiation, carotid artery occlusion, collagen vascular disease, and vitritis. (5684309)
1968
50
Micro-angiography in retinal vascular occlusion. (5255238)
1967

Genetic Variations for Retinal Vascular Occlusion

Expression for genes affiliated with Retinal Vascular Occlusion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for genes affiliated with Retinal Vascular Occlusion

Sources:
54Reactome, 53R&D Systems, 38NCBI BioSystems Database, 52QIAGEN
See all sources

Pathways related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINC1, F5
2
Hide members
9.5SERPINC1, F5
39.3SERPINC1, VEGFA
4
Hide members
9.1SELP, VEGFA, F5

Compounds for genes affiliated with Retinal Vascular Occlusion

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1phosphatidylserine45 29 1112.0APOH, RHO
2uric acid45 2411.0F5, APOH
3inogatran459.9SERPINC1, F5
4batroxobin459.8SELP, F5
5ecarin459.8F5, SERPINC1
6kaolin459.8APOH, F5
7hirugen459.8F5, SERPINC1
8spectrozyme459.8F5, SERPINC1
9nafamostat mesilate459.7F5, SERPINC1
10fluorescein45 1110.7SERPINC1, VEGFA
11danaparoid459.7F5, SERPINC1
12eltrombopag50 1110.7SERPINC1, F5
13sarpogrelate hydrochloride459.7SERPINC1, SELP
14ximelagatran45 1110.7SERPINC1, F5
15nadroparin45 1110.6SERPINC1, SELP
16ancrod459.6F5, SERPINC1
17halothane45 29 1111.5F5, RHO, SELP
18tyrosine sulfate459.5SELP, F5
19heparinoids459.5F5, SERPINC1
20bivalirudin45 1110.4SELP, F5, SERPINC1
21argatroban45 1110.4SERPINC1, F5, SELP
22warfarin45 50 11 2412.4APOH, SERPINC1, SELP
23ristocetin459.4SERPINC1, F5, SELP
24Alpha-D-Mannose119.4APOH, RHO, SERPINC1
25desmopressin45 60 29 1112.4F5, SERPINC1, SELP
26hirudin459.4SELP, F5, SERPINC1
27ticlopidine45 1110.4SELP, APOH, SERPINC1
28protamine459.4F5, SERPINC1, SELP
29dermatan sulfate459.4SERPINC1, SELP, F5
30vitamin b12459.3MTHFR, F5, APOH
31aprotinin45 1110.3F5, SELP, SERPINC1
32Dalteparin119.3VEGFA, SELP, SERPINC1
33progestin459.2F5, SERPINC1, VEGFA
34fondaparinux459.2SERPINC1, F5
35betacarotene459.2RHO, MTHFR, APOH
36atorvastatin45 50 29 11 2413.1SELP, VEGFA, F5
37dextran sulfate459.1F5, APOH, SELP, SERPINC1
38kininogen459.0APOH, F5, SERPINC1, SELP
39cyclophosphamide45 50 1110.9PIGA, MTHFR, F5, APOH
40polysaccharide458.9SELP, SERPINC1, RHO, F5
41folate458.7F5, MTHFR, SERPINC1, APOH
42arginine458.5SELP, SERPINC1, F5, RHO, APOH
43homocysteine45 249.2MTHFR, APOH, SERPINC1, SELP, F5
44aspirin45 50 29 2411.2MTHFR, SELP, F5, APOH, SERPINC1
45heparin45 29 11 2411.2SELP, RHO, MTHFR, APOH, VEGFA
46fibrinogen458.2APOH, F5, MTHFR, SELP, SERPINC1
47creatinine458.2F5, MTHFR, SELP, SERPINC1, APOH
48prostacyclin458.1VEGFA, F5, RHO, SELP, SERPINC1, APOH
49vegf458.1F5, APOH, RHO, VEGFA, SELP, SERPINC1
50estrogen457.7SERPINC1, SELP, VEGFA, MTHFR, F5, APOH

GO Terms for genes affiliated with Retinal Vascular Occlusion

Sources:
16Gene Ontology
See all sources

Cellular components related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6VEGFA, F5
2extracellular spaceGO:0056157.8SERPINC1, SELP, VEGFA, F5, APOH

Biological processes related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.4SELP, VEGFA
2blood circulationGO:0080159.3MTHFR, F5
3platelet degranulationGO:0025769.2SELP, VEGFA, F5
4platelet activationGO:0301688.8SELP, VEGFA, F5
5blood coagulationGO:0075968.4F5, VEGFA, SELP, SERPINC1

Molecular functions related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.3SELP, APOH
2heparin bindingGO:0082018.3APOH, VEGFA, SELP, SERPINC1
3protein bindingGO:0055157.2RHO, VEGFA, PIGA, APOH, SELP, SERPINC1

Products for genes affiliated with Retinal Vascular Occlusion

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vascular Occlusion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet