MCID: RTN021
MIFTS: 49

Retinal Vascular Occlusion malady

Eye diseases, Cardiovascular diseases categories

Summaries for Retinal Vascular Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Vascular Occlusion, also known as retinal vascular occlusion, unspecified, is related to retinitis and retinal vein occlusion. An important gene associated with Retinal Vascular Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Common Pathway. The compounds phosphatidylserine and uric acid have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Retinal Vascular Occlusion

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

retinal vascular occlusion 8 44 60
retinal vascular occlusion, unspecified 8
unspecified retinal vascular occlusion 8
retinal vascular occlusion nos 8
cardiovascular occlusion 60
retinal vasc. occlusion 8


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Disease Ontology8 DOID:1729
ICD9CM27 362.30, 362.3
NCIt39 C34980
ICD1025 H34

Related Diseases for Retinal Vascular Occlusion

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17GeneCards, 18GeneDecks
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Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.5RHO
2retinal vein occlusion30.6APOH, F5, MTHFR, VEGFA, SERPINC1
3vascular disease30.6APOH, VEGFA, SELP, SERPINC1
4retinal artery occlusion30.5APOH
5central retinal vein occlusion30.5VEGFA, MTHFR, F5, APOH
6protein c deficiency30.5APOH, F5, MTHFR, SERPINC1
7thrombophilia30.4APOH, F5, MTHFR, SELP, SERPINC1
8branch retinal artery occlusion30.1F5
9hemoglobinuria30.1PIGA
10purpura30.1SERPINC1
11atherosclerosis30.1APOH, MTHFR, SELP, SERPINC1
12antiphospholipid syndrome30.1APOH, F5, MTHFR, SELP, SERPINC1
13retinal disease10.5
14central retinal artery occlusion10.4
15retinal vascular disease10.4
16glaucoma10.3
17traumatic glaucoma10.1
18exfoliation syndrome10.1
19ischemic neuropathy10.1
20retinitis pigmentosa10.1
21thrombotic thrombocytopenic purpura10.1
22ischemic optic neuropathy10.1
23hemiplegia10.1
24neuropathy10.1
25papilledema10.1
26patent foramen ovale10.0F5
27thrombophlebitis10.0APOH
28deficiency anemia10.0PIGA
29hepatic vein thrombosis10.0PIGA
30quebec platelet disorder10.0F5
31splenic infarction10.0APOH
32autoimmune hemolytic anemia10.0PIGA
33chagas disease10.0RHO
34cystic fibrosis10.0RHO
35essential hypertension10.0SELP
36myeloma10.0VEGFA
37kidney cancer10.0VEGFA
38sickle cell disease10.0SELP
39intermittent claudication10.0SELP
40carotid stenosis10.0SELP
41hypercholesterolemia10.0SELP
42nephrotic syndrome10.0SERPINC1
43polycythemia vera10.0SELP
44uveitis10.0RHO
45liver cirrhosis10.0SERPINC1
46endometriosis10.0VEGFA
47lung cancer10.0VEGFA
48endophthalmitis10.0VEGFA
49peritonitis10.0SELP
50psoriasis10.0SELP

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to retinal vascular occlusion

Clinical Features for Retinal Vascular Occlusion

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Drugs & Therapeutics for Retinal Vascular Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Retinal Vascular Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vascular Occlusion

Search NIH Clinical Center for Retinal Vascular Occlusion

Search CenterWatch for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

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Anatomical Context for Retinal Vascular Occlusion

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32MalaCards
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MalaCards organs/tissues related to Retinal Vascular Occlusion:

32
Eye, Endothelial

Animal Models for Retinal Vascular Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9RHO
2MP:00053859.5RHO, SELP
3MP:00107719.2VEGFA, PIGA
4MP:00036316.9MTHFR, PIGA, F5, RHO, VEGFA, SELP
5MP:00053766.9MTHFR, RHO, VEGFA, SELP, SERPINC1, APOH
6MP:00107686.9SERPINC1, SELP, VEGFA, MTHFR, F5, APOH

Publications for Retinal Vascular Occlusion

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50PubMed
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Articles related to Retinal Vascular Occlusion:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Vascular endothelial growth factor promotes progressive retinal nonperfusion in patients with retinal vein occlusion. (23260261)
2013
2
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. (23869159)
2013
3
Pipeline embolization device: a new source for embolic retinal vascular occlusion. (24051422)
2013
4
Vascular remodeling in central retinal vein occlusion following laser-induced chorioretinal anastomosis. (23494049)
2013
5
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. (24034133)
2013
6
Anti-vascular endothelial growth factors in the treatment of macular oedema secondary to central retinal vein occlusion: a meta-analysis. (24330277)
2013
7
Thrombophilia and retinal vascular occlusion. (22969282)
2012
8
Effect of intravitreal anti-vascular endothelial growth factor treatment on the retinal gene expression in acute experimental central retinal vein occlusion. (22116547)
2012
9
Vascular endothelial growth factor and interleukin-6 are correlated with serous retinal detachment in central retinal vein occlusion. (21978265)
2012
10
Effects of apelin and vascular endothelial growth factor on central retinal vein occlusion in monkey eyes intravitreally injected with bevacizumab: a preliminary study. (21552499)
2011
11
Significant correlation between electroretinogram parameters and ocular vascular endothelial growth factor concentration in central retinal vein occlusion eyes. (21642626)
2011
12
Macular ischaemia after intravitreal bevacizumab injection in patients with central retinal vein occlusion and a history of diabetes and vascular disease. (20215378)
2010
13
Factor V Leiden mutation with retinal vascular occlusion. (21199226)
2010
14
Long-term study of vascular perfusion effects following arteriovenous sheathotomy for branch retinal vein occlusion. (20222903)
2010
15
Increase of vascular endothelial growth factor and interleukin-6 in the aqueous humour of patients with macular oedema and central retinal vein occlusion. (19563372)
2010
16
Anti-vascular endothelial growth factor for macular edema secondary to central retinal vein occlusion. (20927757)
2010
17
Retinal vascular occlusion syndromes. (19584622)
2009
18
Vitreous levels of interleukin-6 and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (19118700)
2009
19
Role of hyperhomocystinemia in retinal vascular occlusive disease. (17164500)
2007
20
Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated with macular edema in branch retinal vein occlusion. (16133018)
2006
21
Retinal vascular occlusion following ocular contusion. (15931542)
2005
22
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. (15710833)
2005
23
Retinal vascular occlusion in patients infected with human immunodeficiency virus. (16141865)
2005
24
The characteristics of retinitis pigmentosa with retinal vascular occlusion]. (15938805)
2005
25
Hyperhomocysteinaemia: risk of retinal vascular occlusion. (16335656)
2004
26
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. (12881356)
2003
27
Thrombophilia factors as inducers of retinal vascular occlusion]. (11450475)
2001
28
Thermolabile MTHFR genotype and retinal vascular occlusive disease. (11133719)
2001
29
Systemic disorders associated with retinal vascular occlusion. (11141642)
2000
30
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653431)
2000
31
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653432)
2000
32
Retinal vascular occlusion and deficiencies in the protein C pathway. (10482096)
1999
33
Delayed diagnosis of homocystinuria as a cause of vascular retinal occlusion in young adults. (10610111)
1999
34
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: implications for increased vascular risk. (9683948)
1998
35
Cocaine-associated retinal vascular occlusion: report of two cases. (8059789)
1994
36
Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. (8002838)
1994
37
Retinal vascular occlusion without retrobulbar or optic nerve sheath hemorrhage after retrobulbar injection of lidocaine. (3231409)
1988
38
Massive bilateral retinal vascular occlusion secondary to thrombotic thrombocytopenic purpura. (2976518)
1988
39
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. (3721721)
1986
40
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. (3721722)
1986
41
Occlusive retinal vascular disease in systemic lupus erythematosus. (6084063)
1984
42
Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. (6192376)
1983
43
Retinal vascular occlusion. (7013655)
1981
44
Retinal vascular occlusion and thrombocyte aggregation. (6931872)
1980
45
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978
46
Ocular hypotony after retinal vascular occlusion. (281809)
1977
47
Abnormal glucose tolerance in association with retinal vascular occlusion. (4752297)
1973
48
Retinal vascular occlusion as a presenting feature of glaucoma simplex. (5575222)
1971
49
A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. VI. X-ray irradiation, carotid artery occlusion, collagen vascular disease, and vitritis. (5684309)
1968
50
Micro-angiography in retinal vascular occlusion. (5255238)
1967

Genetic Variations for Retinal Vascular Occlusion

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Expression for genes affiliated with Retinal Vascular Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for genes affiliated with Retinal Vascular Occlusion

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53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINC1, F5
2
Hide members
9.5SERPINC1, F5
39.3SERPINC1, VEGFA
4
Hide members
9.1SELP, VEGFA, F5

Compounds for genes affiliated with Retinal Vascular Occlusion

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1phosphatidylserine44 28 1112.0APOH, RHO
2uric acid44 2411.0F5, APOH
3inogatran449.9SERPINC1, F5
4batroxobin449.8SELP, F5
5ecarin449.8F5, SERPINC1
6kaolin449.8APOH, F5
7hirugen449.8F5, SERPINC1
8spectrozyme449.8F5, SERPINC1
9nafamostat mesilate449.7F5, SERPINC1
10fluorescein44 1110.7SERPINC1, VEGFA
11danaparoid449.7F5, SERPINC1
12eltrombopag49 1110.7SERPINC1, F5
13sarpogrelate hydrochloride449.7SERPINC1, SELP
14ximelagatran44 1110.7SERPINC1, F5
15nadroparin44 1110.6SERPINC1, SELP
16ancrod449.6F5, SERPINC1
17halothane44 28 1111.5F5, RHO, SELP
18tyrosine sulfate449.5SELP, F5
19heparinoids449.5F5, SERPINC1
20bivalirudin44 1110.4SELP, F5, SERPINC1
21argatroban44 1110.4SERPINC1, F5, SELP
22warfarin44 49 11 2412.4APOH, SERPINC1, SELP
23ristocetin449.4SERPINC1, F5, SELP
24Alpha-D-Mannose119.4APOH, RHO, SERPINC1
25desmopressin44 59 28 1112.4F5, SERPINC1, SELP
26hirudin449.4SELP, F5, SERPINC1
27ticlopidine44 1110.4SELP, APOH, SERPINC1
28protamine449.4F5, SERPINC1, SELP
29dermatan sulfate449.4SERPINC1, SELP, F5
30vitamin b12449.3MTHFR, F5, APOH
31aprotinin44 1110.3F5, SELP, SERPINC1
32Dalteparin119.3VEGFA, SELP, SERPINC1
33progestin449.2F5, SERPINC1, VEGFA
34fondaparinux449.2SERPINC1, F5
35betacarotene449.2RHO, MTHFR, APOH
36atorvastatin44 49 28 11 2413.1SELP, VEGFA, F5
37dextran sulfate449.1F5, APOH, SELP, SERPINC1
38kininogen449.0APOH, F5, SERPINC1, SELP
39cyclophosphamide44 49 1110.9PIGA, MTHFR, F5, APOH
40polysaccharide448.9SELP, SERPINC1, RHO, F5
41folate448.7F5, MTHFR, SERPINC1, APOH
42arginine448.5SELP, SERPINC1, F5, RHO, APOH
43homocysteine44 249.2MTHFR, APOH, SERPINC1, SELP, F5
44aspirin44 49 28 2411.2MTHFR, SELP, F5, APOH, SERPINC1
45heparin44 28 11 2411.2SELP, RHO, MTHFR, APOH, VEGFA
46fibrinogen448.2APOH, F5, MTHFR, SELP, SERPINC1
47creatinine448.2F5, MTHFR, SELP, SERPINC1, APOH
48prostacyclin448.1VEGFA, F5, RHO, SELP, SERPINC1, APOH
49vegf448.1F5, APOH, RHO, VEGFA, SELP, SERPINC1
50estrogen447.7SERPINC1, SELP, VEGFA, MTHFR, F5, APOH

GO Terms for genes affiliated with Retinal Vascular Occlusion

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16Gene Ontology
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Cellular components related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6VEGFA, F5
2extracellular spaceGO:0056157.8SERPINC1, SELP, VEGFA, F5, APOH

Biological processes related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.4SELP, VEGFA
2blood circulationGO:0080159.3MTHFR, F5
3platelet degranulationGO:0025769.2SELP, VEGFA, F5
4platelet activationGO:0301688.8SELP, VEGFA, F5
5blood coagulationGO:0075968.4F5, VEGFA, SELP, SERPINC1

Molecular functions related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.3SELP, APOH
2heparin bindingGO:0082018.3APOH, VEGFA, SELP, SERPINC1
3protein bindingGO:0055157.2RHO, VEGFA, PIGA, APOH, SELP, SERPINC1

Products for genes affiliated with Retinal Vascular Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vascular Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet