MCID: RTN021
MIFTS: 45

Retinal Vascular Occlusion

Categories: Eye diseases, Cardiovascular diseases

Aliases & Classifications for Retinal Vascular Occlusion

MalaCards integrated aliases for Retinal Vascular Occlusion:

Name: Retinal Vascular Occlusion 12 51 14 69
Retinal Vascular Occlusion, Unspecified 12
Unspecified Retinal Vascular Occlusion 12
Retinal Vascular Occlusion Nos 12
Retinal Vasc. Occlusion 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1729
ICD10 32 H34 H34.9
ICD9CM 34 362.3 362.30
NCIt 46 C34980
UMLS 69 C0035326

Summaries for Retinal Vascular Occlusion

MalaCards based summary : Retinal Vascular Occlusion, also known as retinal vascular occlusion, unspecified, is related to central retinal artery occlusion and central retinal vein occlusion, and has symptoms including amaurosis fugax An important gene associated with Retinal Vascular Occlusion is APOH (Apolipoprotein H), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Selenium Micronutrient Network. The drugs Bevacizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Retinal Vascular Occlusion

Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 central retinal artery occlusion 30.7 FANCG PLG
2 central retinal vein occlusion 30.3 APOH F2 F5 MTHFR SERPINC1 VEGFA
3 papilledema 30.0 APOH F2
4 retinal vasculitis 29.8 APOH CCL2
5 purpura 29.7 APOH F2 SERPINC1
6 nonarteritic anterior ischemic optic neuropathy 29.3 F2 F5 MTHFR SERPINC1
7 ischemic optic neuropathy 29.2 APOH F2 F5 MTHFR SERPINC1
8 arteritic anterior ischemic optic neuropathy 29.2 F2 F5 FANCG MTHFR
9 thrombophilia 29.0 APOH F2 F5 MTHFR PLG SERPINC1
10 retinal artery occlusion 29.0 APOH F2 F5 MTHFR SERPINC1
11 antiphospholipid syndrome 28.9 APOH F2 F5 MTHFR SELP SERPINC1
12 branch retinal artery occlusion 28.7 APOH F2 FANCG MTHFR SERPINC1
13 retinal vein occlusion 28.3 APOH CCL2 F2 F5 MTHFR SERPINC1
14 retinitis 10.6
15 may-thurner syndrome 10.5 APOH F5
16 acanthamoeba keratitis 10.5 APOH F5
17 inferior vena cava interruption 10.4 F5 MTHFR
18 amaurosis fugax 10.4 F5 MTHFR
19 vitreous detachment 10.4 PLG VEGFA
20 heparin-induced thrombocytopenia 10.4 SELP SERPINC1
21 hemifacial spasm 10.4 MTHFR VEGFA
22 chronic myocardial ischemia 10.4 PLG VEGFA
23 platelet aggregation, spontaneous 10.4 SELP SERPINC1
24 quebec platelet disorder 10.4 F5 SELP
25 sticky platelet syndrome 10.4 F5 SERPINC1
26 paracetamol poisoning 10.4 F2 F5
27 qualitative platelet defect 10.4 F2 SELP
28 carotid artery occlusion 10.4 APOH F5
29 splenic infarction 10.4 APOH F2
30 endophthalmitis 10.4 PLG VEGFA
31 hemoglobin e disease 10.3 F2 F5
32 cerebral falx meningioma 10.3 F2 PLG
33 mitral valve stenosis 10.3 SELP SERPINC1
34 factor viii deficiency 10.3 F2 F5
35 mesenteric vascular occlusion 10.3 F2 MTHFR
36 lateral medullary syndrome 10.3 APOH PLG
37 lemierre's syndrome 10.3 MTHFR PLG
38 femoral neuropathy 10.3 F2 PLG
39 anterior cranial fossa meningioma 10.3 F2 PLG
40 meningococcemia 10.3 F5 SERPINC1
41 ischemic neuropathy 10.3 F2 MTHFR
42 fournier gangrene 10.3 F2 SERPINC1
43 factor v deficiency 10.3 F2 F5
44 pregnancy loss, recurrent 1 10.3 APOH F5 MTHFR
45 stormorken syndrome 10.2 F2 SELP
46 neovascular glaucoma 10.2 PGF VEGFA
47 catastrophic antiphospholipid syndrome 10.2 APOH F5 MTHFR
48 basilar artery occlusion 10.2 F2 PLG
49 transient retinal arterial occlusion 10.2
50 epithelioid hemangioendothelioma 10.2 PGF VEGFA

Comorbidity relations with Retinal Vascular Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to Retinal Vascular Occlusion

Symptoms & Phenotypes for Retinal Vascular Occlusion

UMLS symptoms related to Retinal Vascular Occlusion:


amaurosis fugax

MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 SERPINC1 VEGFA APOH F2 F5 MTHFR
2 cardiovascular system MP:0005385 9.8 SELP SERPINC1 VEGFA F2 F5 PGF
3 integument MP:0010771 9.5 VEGFA F2 F5 MTHFR PGF PLG
4 vision/eye MP:0005391 9.1 SELP SERPINC1 VEGFA MTHFR PGF PLG

Drugs & Therapeutics for Retinal Vascular Occlusion

Drugs for Retinal Vascular Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 3,Phase 2 216974-75-3
2 Angiogenesis Inhibitors Phase 2
3 Angiogenesis Modulating Agents Phase 2
4 Endothelial Growth Factors Phase 2
5 Mitogens Phase 2
6
Bazedoxifene Approved, Investigational 198481-32-2
7 Bone Density Conservation Agents
8 Diphosphonates
9 Estrogen Antagonists
10 Estrogen Receptor Modulators
11 Estrogens
12 Hormone Antagonists
13 Hormones
14 Hormones, Hormone Substitutes, and Hormone Antagonists
15 Raloxifene Hydrochloride
16 Selective Estrogen Receptor Modulators

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bevacizumab and Retinal Vascular Occlusions Unknown status NCT00347711 Phase 3 Intravitreal injection
2 Pain and Visual Outcome in Intravitreal Bevacizumab Injection Completed NCT02790775 Phase 2 Anti-VEGF in quadrant 1;Anti-VEGF in quadrant 2;Anti-VEGF in quadrant 3;Anti-VEGF in quadrant 4
3 Body-fluid Balance and Drinking Habits in Patients With Retinal Vascular Occlusion Unknown status NCT01939119
4 Obstructive Sleep Apnea, Retinal Vein Occlusion, Retinal Artery Occlusion Unknown status NCT01291862
5 Prevalence of Vitreomacular Adhesion in Patients 40 Years and Older Active, not recruiting NCT02160340
6 Bazedoxifene Post Approval Safety Study (PASS) in the European Union (EU) Active, not recruiting NCT01416194 Bazedoxifene;Bisphosphonate;Raloxifene
7 Swept-Source Optical Coherence Tomography for Noninvasive Retinal Vascular Imaging Terminated NCT01834196

Search NIH Clinical Center for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

Anatomical Context for Retinal Vascular Occlusion

MalaCards organs/tissues related to Retinal Vascular Occlusion:

38
Eye, Endothelial, Bone

Publications for Retinal Vascular Occlusion

Articles related to Retinal Vascular Occlusion:

(show top 50) (show all 77)
# Title Authors Year
1
Retinal Vascular Occlusion Secondary to Retrobulbar Injection: Case Report and Literature Review. ( 28546695 )
2017
2
Atrial fibrillation in retinal vascular occlusion disease and non-arteritic anterior ischemic optic neuropathy. ( 28771491 )
2017
3
Retinal vascular occlusion: a window to diagnosis of familial and acquired thrombophilia and hypofibrinolysis, with important ramifications for pregnancy outcomes. ( 27563233 )
2016
4
Venous thromboembolism does not share familial susceptibility with retinal vascular occlusion or glaucoma: a nationwide family study. ( 27283943 )
2016
5
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS. ( 27533640 )
2016
6
SEVERE BILATERAL RETINAL VASCULAR OCCLUSION AS FIRST PRESENTATION OF SYSTEMIC LUPUS ERYTHEMATOSUS AND ANTIPHOSPHOLIPID SYNDROME. ( 27548039 )
2016
7
Risk of Mortality and of Atherosclerotic Events Among Patients Who Underwent Hemodialysis and Subsequently Developed Retinal Vascular Occlusion: A Taiwanese Retrospective Cohort Study. ( 26720586 )
2016
8
Pipeline embolization device: a new source for embolic retinal vascular occlusion. ( 24051422 )
2013
9
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. ( 23869159 )
2013
10
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. ( 24034133 )
2013
11
Thrombophilia and retinal vascular occlusion. ( 22969282 )
2012
12
Central retinal vascular occlusion associated with acute retinal necrosis. ( 22491922 )
2012
13
Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia-observational case series and survey of literature. ( 21850439 )
2011
14
Factor V Leiden mutation with retinal vascular occlusion. ( 21199226 )
2010
15
Retinal vascular occlusions occur more frequently in the more affected eye in exfoliation syndrome. ( 19557023 )
2010
16
Retinal vascular occlusion during in vitro fertilization. ( 25390129 )
2010
17
Retinal vascular occlusion syndromes. ( 19584622 )
2009
18
Paroxysmal nocturnal hemoglobinuria may cause retinal vascular occlusions. ( 18437293 )
2009
19
Retinal vascular occlusions: an interdisciplinary challenge. ( 19626196 )
2008
20
Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion. ( 17481600 )
2007
21
Role of hyperhomocystinemia in retinal vascular occlusive disease. ( 17164500 )
2007
22
Inappropriate investigation and management of a retinal vascular occlusion. ( 16082396 )
2006
23
Retinal vascular occlusion following ocular contusion. ( 15931542 )
2005
24
[The characteristics of retinitis pigmentosa with retinal vascular occlusion]. ( 15938805 )
2005
25
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. ( 16197292 )
2005
26
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. ( 15710833 )
2005
27
Retinal vascular occlusion following traumatic hyphema and glaucoma, as a presenting sign of sickle cell trait. ( 16011069 )
2005
28
Retinal vascular occlusion in patients infected with human immunodeficiency virus. ( 16141865 )
2005
29
Central retinal vascular occlusion by orbital pseudotumor. ( 15187672 )
2004
30
Hyperhomocysteinaemia: risk of retinal vascular occlusion. ( 16335656 )
2004
31
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. ( 14644226 )
2003
32
Unilateral peripheral retinal vascular occlusion in a young Japanese woman with neurofibromatosis-1. ( 12972769 )
2003
33
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. ( 12881356 )
2003
34
[Retinal vascular occlusion and primary antiphospholipid syndrome. Report of 2 cases]. ( 11912840 )
2001
35
[Thrombophilia factors as inducers of retinal vascular occlusion]. ( 11450475 )
2001
36
Thermolabile MTHFR genotype and retinal vascular occlusive disease. ( 11133719 )
2001
37
The electroretinogram in patients with retinal vascular occlusion. ( 12567597 )
2001
38
Systemic disorders associated with retinal vascular occlusion. ( 11141642 )
2000
39
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653432 )
2000
40
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10653431 )
2000
41
Retinal vascular occlusion and deficiencies in the protein C pathway. ( 10482096 )
1999
42
Genetic thrombophilia in patients with retinal vascular occlusion. ( 11456253 )
1999
43
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: implications for increased vascular risk. ( 9683948 )
1998
44
Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance. ( 9372725 )
1997
45
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. ( 9152086 )
1997
46
Cocaine-associated retinal vascular occlusion: report of two cases. ( 8059789 )
1994
47
Antiphospholipid antibodies in retinal vascular occlusions. A prospective study of 75 patients. ( 8002838 )
1994
48
Lipoprotein (a): a risk factor for retinal vascular occlusion. ( 1477637 )
1992
49
The investigation of patients with retinal vascular occlusion. ( 2209910 )
1990
50
Massive bilateral retinal vascular occlusion. ( 2475899 )
1989

Variations for Retinal Vascular Occlusion

Expression for Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for Retinal Vascular Occlusion

GO Terms for Retinal Vascular Occlusion

Cellular components related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.56 APOH CCL2 F2 F5 PGF PLG
2 blood microparticle GO:0072562 9.43 F2 PLG SERPINC1
3 platelet alpha granule lumen GO:0031093 9.33 F5 PLG VEGFA
4 extracellular space GO:0005615 9.28 APOH CCL2 F2 F5 PGF PLG

Biological processes related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.84 CCL2 F2 PGF VEGFA
2 response to hypoxia GO:0001666 9.72 MTHFR PGF VEGFA
3 regulation of cell shape GO:0008360 9.69 CCL2 F2 VEGFA
4 cellular protein metabolic process GO:0044267 9.67 F2 F5 PLG SERPINC1
5 blood coagulation GO:0007596 9.62 F2 F5 PLG SERPINC1
6 fibrinolysis GO:0042730 9.52 F2 PLG
7 blood coagulation, intrinsic pathway GO:0007597 9.49 APOH F2
8 positive regulation of leukocyte migration GO:0002687 9.48 SELP VEGFA
9 positive regulation of blood coagulation GO:0030194 9.46 APOH F2
10 induction of positive chemotaxis GO:0050930 9.43 PGF VEGFA
11 regulation of blood coagulation GO:0030193 9.43 APOH F2 SERPINC1
12 positive regulation of mast cell chemotaxis GO:0060754 9.4 PGF VEGFA
13 negative regulation of fibrinolysis GO:0051918 9.33 APOH F2 PLG
14 hemostasis GO:0007599 9.26 F2 F5 PLG SERPINC1
15 platelet degranulation GO:0002576 9.02 APOH F5 PLG SELP VEGFA

Molecular functions related to Retinal Vascular Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.33 F2 PGF VEGFA
2 lipopolysaccharide binding GO:0001530 9.26 F2 SELP
3 heparin binding GO:0008201 9.1 APOH F2 PGF SELP SERPINC1 VEGFA
4 vascular endothelial growth factor receptor binding GO:0005172 8.96 PGF VEGFA

Sources for Retinal Vascular Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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