MCID: RTN021
MIFTS: 47

Retinal Vascular Occlusion malady

Eye diseases, Cardiovascular diseases categories

Summaries for Retinal Vascular Occlusion

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66Wikipedia, 34MalaCards
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Wikipedia:66 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Vascular Occlusion, also known as retinal vascular occlusion, unspecified, is related to retinal vein occlusion and thrombophilia. An important gene associated with Retinal Vascular Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Integrated Breast Cancer Pathway and Hemostasis. The compounds kaolin and coumarins have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are integument and cardiovascular system.

Aliases & Classifications for Retinal Vascular Occlusion

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9Disease Ontology, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

retinal vascular occlusion 9 46 63
retinal vascular occlusion, unspecified 9
unspecified retinal vascular occlusion 9
retinal vascular occlusion nos 9
cardiovascular occlusion 63
retinal vasc. occlusion 9


External Ids:

Disease Ontology9 DOID:1729
ICD9CM28 362.30, 362.3
NCIt41 C34980
ICD1026 H34

Related Diseases for Retinal Vascular Occlusion

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 63)
idRelated DiseaseScoreTop Affiliating Genes
1retinal vein occlusion30.6F5, APOH, VEGFA
2thrombophilia30.5F5, SELP, APOH
3retinal artery occlusion30.3APOH
4central retinal vein occlusion30.2VEGFA, APOH, F5
5blindness30.2RHO, VEGFA
6antiphospholipid syndrome30.2F5, SELP, APOH
7retinitis11.1
8glaucoma10.3
9retinal disease10.3
10thrombotic thrombocytopenic purpura10.1
11hemoglobinuria10.1
12retinitis pigmentosa10.1
13exfoliation syndrome10.1
14branch retinal artery occlusion10.1
15central retinal artery occlusion10.1
16atherosclerosis10.1
17hemiplegia10.1
18neuropathy10.1
19papilledema10.1
20purpura10.1
21paroxysmal nocturnal hemoglobinuria10.1
22quebec platelet disorder10.1F5
23purpura fulminans10.1F5
24sneddon syndrome10.1APOH
25patent foramen ovale10.1F5
26thrombophlebitis10.1APOH
27endophthalmitis10.1VEGFA
28mondor disease10.1APOH, F5
29prothrombin deficiency10.1F5, APOH
30hepatic vein thrombosis10.1APOH, F5
31antithrombin iii deficiency10.1APOH, F5
32intracranial thrombosis10.1APOH, F5
33factor xii deficiency10.1F5, APOH
34severe pre-eclampsia10.1APOH, F5
35hellp syndrome10.1APOH, F5
36protein c deficiency10.1APOH, F5
37ovarian hyperstimulation syndrome10.1VEGFA, F5
38pulmonary embolism10.0APOH, F5
39pregnancy loss10.0APOH, F5
40behcet's disease10.0APOH, F5
41protein s deficiency10.0PIGA, F5
42age related macular degeneration10.0RHO, VEGFA
43lupus erythematosus10.0APOH, F5
44von willebrand's disease10.0SELP, F5
45factor viii deficiency10.0F5, SELP
46hemolytic anemia10.0APOH, PIGA
47diabetic retinopathy10.0RHO, VEGFA
48thrombotic thrombocytopenic purpura, acquired10.0APOH, SELP
49adult respiratory distress syndrome10.0SELP, F5
50cerebrovascular disease10.0APOH, SELP

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to retinal vascular occlusion

Symptoms for Retinal Vascular Occlusion

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Drugs & Therapeutics for Retinal Vascular Occlusion

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Retinal Vascular Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vascular Occlusion

Search NIH Clinical Center for Retinal Vascular Occlusion

Search CenterWatch for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

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Anatomical Context for Retinal Vascular Occlusion

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34MalaCards
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MalaCards organs/tissues related to Retinal Vascular Occlusion:

34
Eye

Animal Models for Retinal Vascular Occlusion or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107718.2F5, SELP, VEGFA, PIGA
2MP:00053858.1F5, RHO, SELP, VEGFA
3MP:00053868.1F5, SELP, VEGFA, PIGA
4MP:00053767.9VEGFA, APOH, SELP, RHO, F5
5MP:00036317.7F5, RHO, SELP, VEGFA, PIGA
6MP:00053977.7PIGA, VEGFA, SELP, RHO
7MP:00107687.6PIGA, VEGFA, APOH, SELP, F5

Publications for Retinal Vascular Occlusion

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53PubMed
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Articles related to Retinal Vascular Occlusion:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. (23869159)
2013
2
Pipeline embolization device: a new source for embolic retinal vascular occlusion. (24051422)
2013
3
Impact of cilostazol on the progression of carotid atherosclerosis in patients with retinal vascular occlusion. (24034133)
2013
4
Thrombophilia and retinal vascular occlusion. (22969282)
2012
5
Central retinal vascular occlusion associated with acute retinal necrosis. (22491922)
2012
6
Retinal vascular occlusion after vitrectomy with retrobulbar anesthesia-observational case series and survey of literature. (21850439)
2011
7
Factor V Leiden mutation with retinal vascular occlusion. (21199226)
2010
8
Retinal vascular occlusion syndromes. (19584622)
2009
9
Retinal vascular occlusions: an interdisciplinary challenge. (19626196)
2008
10
Low density lipoprotein triglycerides and lipoprotein(a) are risk factors for retinal vascular occlusion. (17481600)
2007
11
Role of hyperhomocystinemia in retinal vascular occlusive disease. (17164500)
2007
12
Retinal vascular occlusion following ocular contusion. (15931542)
2005
13
Retinal vascular occlusion following traumatic hyphema and glaucoma, as a presenting sign of sickle cell trait. (16011069)
2005
14
Retinal vascular occlusion with overlying vitreous hemorrhage masquerading as a tumor. (15710833)
2005
15
Retinal vascular occlusion in patients infected with human immunodeficiency virus. (16141865)
2005
16
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. (16197292)
2005
17
Central retinal vascular occlusion by orbital pseudotumor. (15187672)
2004
18
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. (14644226)
2003
19
Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with BehAset's disease. (12881356)
2003
20
Unilateral peripheral retinal vascular occlusion in a young Japanese woman with neurofibromatosis-1. (12972769)
2003
21
Retinal vascular occlusion and primary antiphospholipid syndrome. Report of 2 cases]. (11912840)
2001
22
The electroretinogram in patients with retinal vascular occlusion. (12567597)
2001
23
Systemic disorders associated with retinal vascular occlusion. (11141642)
2000
24
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653431)
2000
25
Retinal vascular occlusion and deficiencies in the protein C pathway. (10653432)
2000
26
Retinal vascular occlusion and deficiencies in the protein C pathway. (10482096)
1999
27
Genetic thrombophilia in patients with retinal vascular occlusion. (11456253)
1999
28
Abnormalities in haemorheological factors and lipoprotein (a) in retinal vascular occlusion: implications for increased vascular risk. (9683948)
1998
29
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. (9152086)
1997
30
Cocaine-associated retinal vascular occlusion: report of two cases. (8059789)
1994
31
Lipoprotein (a): a risk factor for retinal vascular occlusion. (1477637)
1992
32
The investigation of patients with retinal vascular occlusion. (2209910)
1990
33
Massive bilateral retinal vascular occlusion. (2475899)
1989
34
Retinal vascular occlusion without retrobulbar or optic nerve sheath hemorrhage after retrobulbar injection of lidocaine. (3231409)
1988
35
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. (3721721)
1986
36
Experimental retinal vascular occlusion. III. An ultrastructural study of simultaneous occlusion of central retinal vein and artery. (3721722)
1986
37
Ocular neovascularization with retinal vascular occlusion-III. Incidence of ocular neovascularization with retinal vein occlusion. (6192376)
1983
38
Ocular neovascularization with retinal vascular occlusion. I. Association with experimental retinal vein occlusion. (6175297)
1982
39
Ocular neovascularization with retinal vascular occlusion. II. Occurrence in central and branch retinal artery occlusion. (6182865)
1982
40
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978
41
Acute infantile hemiplegia associated with ipsilateral retinal vascular occlusion. (4843527)
1974
42
Sudden blindness after ventriculography. Bilateral retinal vascular occlusion superimposed on papilledema. (4546564)
1974
43
Abnormal glucose tolerance in association with retinal vascular occlusion. (4752297)
1973
44
Retinal vascular occlusion in the cat by photocoagulation: trial of a new instrument. (4753336)
1973
45
Fluorescein studies in retinal vascular occlusion. (5635899)
1968
46
Microangiography in retinal vascular occlusion [abstract]. (20919019)
1968
47
CURRENT DEVELOPMENTS IN OPHTHALMOLOGY. FIBRINOLYSIS IN RETINAL VASCULAR OCCLUSION. (14190868)
1964
48
INTRAVENOUS STREPTOKINASE IN THE TREATMENT OF RETINAL VASCULAR OCCLUSION. (14159485)
1964
49
Retinal vascular occlusion associated with gastro-intestinal hemorrhage. (13977191)
1962
50
Anticoagulant therapy in retinal vascular occlusion. (18136778)
1949

Variations for Retinal Vascular Occlusion

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Expression for genes affiliated with Retinal Vascular Occlusion

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for genes affiliated with Retinal Vascular Occlusion

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51PathCards, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4RHO, VEGFA
2
Show member pathways
8.7F5, SELP, VEGFA
3
Show member pathways
8.7F5, SELP, VEGFA

Compounds for genes affiliated with Retinal Vascular Occlusion

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 52PharmGKB, 25HMDB
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Compounds related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 70)
idCompoundScoreTop Affiliating Genes
1kaolin4610.0APOH, F5
2coumarins4610.0F5, APOH
3cardiolipin46 1210.9F5, APOH
4phosphatidylethanolamine46 1210.8F5, APOH
5fluorescein46 1210.8VEGFA, F5
6batroxobin469.7F5, SELP
7tyrosine sulfate469.7F5, SELP
8bivalirudin46 1210.7F5, SELP
9argatroban46 1210.6SELP, F5
10penicillin469.6F5, SELP
1111-dehydrothromboxane b2469.6APOH, SELP
12ristocetin469.6SELP, F5
13ticlopidine46 1210.5SELP, APOH
14desmopressin46 62 30 1212.5SELP, F5
15ptca469.5SELP, APOH
16deoxyribonucleic acid469.5F5, APOH
17fluorochrome469.5SELP, RHO
18hirudin469.5SELP, F5
19quinacrine46 1210.5SELP, APOH
20phosphatidylcholine469.5APOH, RHO, F5
21candesartan46 52 30 1212.4SELP, VEGFA
22phospholipid469.4APOH, RHO, F5
23protamine469.4SELP, F5
24txb2469.4APOH, SELP
25mycophenolate mofetil46 52 1211.4SELP, F5
26dermatan sulfate469.3F5, SELP
27dextran sulfate469.2F5, SELP, APOH
28warfarin46 52 25 1212.2F5, APOH, SELP
29kininogen469.2F5, APOH, SELP
30homocysteine46 2510.2APOH, SELP, F5
31cocaine46 1210.2SELP, APOH, F5
32infliximab46 52 1211.2APOH, VEGFA
33aspirin46 52 30 2512.2APOH, SELP, F5
34halothane46 52 30 1212.2RHO, SELP, F5
35atorvastatin46 52 30 25 1213.1SELP, F5, VEGFA
36simvastatin46 52 62 30 25 1214.1VEGFA, F5, SELP
37fibrinogen469.1F5, SELP, APOH
38epinephrine46 25 1211.1SELP, RHO, F5
39polysaccharide469.1SELP, RHO, F5
40lactate469.0SELP, APOH, F5
41ly294002468.9RHO, VEGFA, SELP
42cyclophosphamide46 52 1210.9VEGFA, APOH, PIGA, F5
43creatinine468.8F5, APOH, SELP
44aspartate468.7RHO, SELP, F5
45phosphatidylserine46 30 1210.7F5, RHO, SELP, APOH
46arginine468.7RHO, APOH, F5, SELP
47estrogen468.6SELP, VEGFA, F5, APOH
48prostacyclin468.2RHO, F5, SELP, APOH, VEGFA
49heparin46 30 25 1211.2F5, VEGFA, APOH, SELP, RHO
50vegf468.2F5, VEGFA, APOH, SELP, RHO

GO Terms for genes affiliated with Retinal Vascular Occlusion

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17Gene Ontology
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Cellular components related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5F5, VEGFA
2extracellular spaceGO:0056158.0F5, SELP, APOH, VEGFA

Biological processes related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.0SELP, VEGFA
2platelet degranulationGO:0025768.7F5, SELP, VEGFA
3blood coagulationGO:0075968.7F5, SELP, VEGFA
4platelet activationGO:0301688.4VEGFA, SELP, F5

Molecular functions related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.2SELP, APOH
2heparin bindingGO:0082018.6SELP, APOH, VEGFA
3protein bindingGO:0055156.8PIGA, VEGFA, APOH, SELP, RHO, F5

Products for genes affiliated with Retinal Vascular Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vascular Occlusion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet