MCID: RTN021
MIFTS: 49

Retinal Vascular Occlusion malady

Eye diseases, Cardiovascular diseases categories

Summaries for Retinal Vascular Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 Ocular ischemic syndrome is the constellation of ocular signs and symptoms secondary to severe, chronic... more...

MalaCards: Retinal Vascular Occlusion, also known as retinal vascular occlusion, unspecified, is related to retinitis and retinal vein occlusion. An important gene associated with Retinal Vascular Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Formation of Fibrin Clot (Clotting Cascade) and Common Pathway. The compounds phosphatidylserine and uric acid have been mentioned in the context of this disorder. Affiliated tissues include eye and endothelial, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Retinal Vascular Occlusion

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases, Cardiovascular diseases


Aliases & Descriptions:

retinal vascular occlusion 8 44 60
retinal vascular occlusion, unspecified 8
unspecified retinal vascular occlusion 8
retinal vascular occlusion nos 8
cardiovascular occlusion 60
retinal vasc. occlusion 8


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Disease Ontology8 DOID:1729
ICD9CM27 362.30, 362.3
NCIt39 C34980
ICD1025 H34

Related Diseases for Retinal Vascular Occlusion

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17GeneCards, 18GeneDecks
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Diseases related to Retinal Vascular Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.5RHO
2retinal vein occlusion30.6APOH, F5, MTHFR, VEGFA, SERPINC1
3vascular disease30.6APOH, VEGFA, SELP, SERPINC1
4retinal artery occlusion30.5APOH
5central retinal vein occlusion30.5VEGFA, MTHFR, F5, APOH
6protein c deficiency30.5APOH, F5, MTHFR, SERPINC1
7thrombophilia30.4APOH, F5, MTHFR, SELP, SERPINC1
8branch retinal artery occlusion30.1F5
9hemoglobinuria30.1PIGA
10purpura30.1SERPINC1
11atherosclerosis30.1APOH, MTHFR, SELP, SERPINC1
12antiphospholipid syndrome30.1APOH, F5, MTHFR, SELP, SERPINC1
13retinal disease10.5
14central retinal artery occlusion10.4
15retinal vascular disease10.4
16glaucoma10.3
17traumatic glaucoma10.1
18exfoliation syndrome10.1
19ischemic neuropathy10.1
20retinitis pigmentosa10.1
21thrombotic thrombocytopenic purpura10.1
22ischemic optic neuropathy10.1
23hemiplegia10.1
24neuropathy10.1
25papilledema10.1
26patent foramen ovale10.0F5
27thrombophlebitis10.0APOH
28deficiency anemia10.0PIGA
29hepatic vein thrombosis10.0PIGA
30quebec platelet disorder10.0F5
31splenic infarction10.0APOH
32autoimmune hemolytic anemia10.0PIGA
33chagas disease10.0RHO
34cystic fibrosis10.0RHO
35essential hypertension10.0SELP
36myeloma10.0VEGFA
37kidney cancer10.0VEGFA
38sickle cell disease10.0SELP
39intermittent claudication10.0SELP
40carotid stenosis10.0SELP
41hypercholesterolemia10.0SELP
42nephrotic syndrome10.0SERPINC1
43polycythemia vera10.0SELP
44uveitis10.0RHO
45liver cirrhosis10.0SERPINC1
46endometriosis10.0VEGFA
47lung cancer10.0VEGFA
48endophthalmitis10.0VEGFA
49peritonitis10.0SELP
50psoriasis10.0SELP

Graphical network of the top 20 diseases related to Retinal Vascular Occlusion:



Diseases related to retinal vascular occlusion

Clinical Features for Retinal Vascular Occlusion

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Drugs & Therapeutics for Retinal Vascular Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Retinal Vascular Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vascular Occlusion

Search NIH Clinical Center for Retinal Vascular Occlusion

Search CenterWatch for Retinal Vascular Occlusion

Genetic Tests for Retinal Vascular Occlusion

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Anatomical Context for Retinal Vascular Occlusion

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32MalaCards
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MalaCards organs/tissues related to Retinal Vascular Occlusion:

32
Eye, Endothelial

Animal Models for Retinal Vascular Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinal Vascular Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9RHO
2MP:00053859.5SELP, RHO
3MP:00107719.2VEGFA, PIGA
4MP:00036316.9SERPINC1, PIGA, F5, MTHFR, RHO, VEGFA
5MP:00053766.9APOH, F5, MTHFR, RHO, VEGFA, SELP
6MP:00107686.9APOH, PIGA, F5, MTHFR, VEGFA, SELP

Publications for Retinal Vascular Occlusion

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50PubMed
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Articles related to Retinal Vascular Occlusion:

(show top 50)    (show all 116)
idTitleAuthorsYear
1
Thrombophilia and vascular risk factors in retinal vein occlusion. (23566482)
2013
2
Correlation between vascular endothelial growth factor and nonperfused areas in macular edema secondary to branch retinal vein occlusion. (23901258)
2013
3
Oral contraceptive pills: A risk factor for retinal vascular occlusion in in-vitro fertilization patients. (23869159)
2013
4
Vascular changes in eyes treated with dexamethasone intravitreal implant for macular edema after retinal vein occlusion. (23499064)
2013
5
Retinal vascular features associated with risk of branch retinal vein occlusion. (23654291)
2013
6
Anti-vascular endothelial growth factor for macular oedema secondary to branch retinal vein occlusion. (23440840)
2013
7
Impaired systemic vascular endothelial function in patients with branch retinal vein occlusion. (23167764)
2013
8
Aqueous soluble vascular endothelial growth factor receptor-2 in macular edema with branch retinal vein occlusion. (23972086)
2013
9
Vascular endothelial growth factor receptor-2 in macular oedema with retinal vein occlusion. (22415022)
2012
10
Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 COPERNICUS study. (22440275)
2012
11
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
12
Role of soluble vascular endothelial growth factor receptor-2 in macular oedema with central retinal vein occlusion. (21109696)
2011
13
Efficacy and safety of anti-vascular endothelial growth factor (VEGF) therapy with intravitreal ranibizumab (Lucentis) for naive retinal vein occlusion: 1-year follow-up. (20601660)
2011
14
Soluble vascular endothelial growth factor receptor-2 and inflammatory factors in macular edema with branch retinal vein occlusion. (21726846)
2011
15
Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema. (20714746)
2010
16
Long-term study of vascular perfusion effects following arteriovenous sheathotomy for branch retinal vein occlusion. (20222903)
2010
17
Vascular risk factors for central retinal artery occlusion. (19521436)
2010
18
Aqueous vascular endothelial growth factor levels are associated with serous macular detachment secondary to branch retinal vein occlusion. (19881397)
2010
19
Changes in foveal thickness after vitrectomy for macular edema with branch retinal vein occlusion and intravitreal vascular endothelial growth factor. (18797821)
2009
20
Changes of aqueous vascular endothelial growth factor and pigment epithelium-derived factor following intravitreal bevacizumab for macular oedema secondary to branch retinal vein occlusion. (19624346)
2009
21
Paroxysmal nocturnal hemoglobinuria may cause retinal vascular occlusions. (18437293)
2009
22
Retinal vascular occlusions: an interdisciplinary challenge. (19626196)
2008
23
Ocular vascular thrombotic events: central retinal vein and central retinal artery occlusions. (18160589)
2008
24
Primary vascular occlusion in IRVAN (idiopathic retinal vasculitis, aneurysms, neuroretinitis) syndrome. (16766406)
2006
25
Retinal vascular occlusion in patients infected with human immunodeficiency virus. (16141865)
2005
26
Impairment of homocysteine metabolism in patients with retinal vascular occlusion and non-arteritic ischemic optic neuropathy. (16197292)
2005
27
Central retinal vascular occlusion by orbital pseudotumor. (15187672)
2004
28
Meta-analysis of plasma homocysteine, serum folate, serum vitamin B(12), and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease. (14644226)
2003
29
Methylenetetrahydrofolate reductase gene polymorphism, hyperhomocysteinemia and occlusive retinal vascular disease in type 2 diabetic and non-diabetic subjects. (12356186)
2002
30
Retinal vascular occlusion and primary antiphospholipid syndrome. Report of 2 cases]. (11912840)
2001
31
The electroretinogram in patients with retinal vascular occlusion. (12567597)
2001
32
Vascular endothelial growth factor upregulation in human central retinal vein occlusion. (9499769)
1998
33
Visual field loss caused by retinal vascular occlusion after vitrectomy surgery. (9152086)
1997
34
Peripheral retinal neovascularization and retinal vascular occlusion associated with activated protein C resistance. (9372725)
1997
35
The investigation of patients with retinal vascular occlusion. (2209910)
1990
36
Ocular neovascularization with retinal vascular occlusion. I. Association with experimental retinal vein occlusion. (6175297)
1982
37
Ocular neovascularization with retinal vascular occlusion. II. Occurrence in central and branch retinal artery occlusion. (6182865)
1982
38
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978
39
Experimental central retinal vascular occlusion. Blood-retinal barrier alterations and retinal lesions. (103251)
1977
40
Occlusive retinal vascular disease and deafness. (949074)
1976
41
Acute infantile hemiplegia associated with ipsilateral retinal vascular occlusion. (4843527)
1974
42
Sudden blindness after ventriculography. Bilateral retinal vascular occlusion superimposed on papilledema. (4546564)
1974
43
Fluorescein studies in retinal vascular occlusion. (5635899)
1968
44
Microangiography in retinal vascular occlusion [abstract]. (20919019)
1968
45
A study of retinal vascular occlusion using fluorescein angiography. (4162168)
1966
46
CURRENT DEVELOPMENTS IN OPHTHALMOLOGY. FIBRINOLYSIS IN RETINAL VASCULAR OCCLUSION. (14190868)
1964
47
INTRAVENOUS STREPTOKINASE IN THE TREATMENT OF RETINAL VASCULAR OCCLUSION. (14159485)
1964
48
Medical Investigation of Retinal Vascular Occlusion. (20790334)
1964
49
Retinal vascular occlusion associated with gastro-intestinal hemorrhage. (13977191)
1962
50
Anticoagulant therapy in retinal vascular occlusion. (18136778)
1949

Genetic Variations for Retinal Vascular Occlusion

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Expression for genes affiliated with Retinal Vascular Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vascular Occlusion

Search GEO for disease gene expression data for Retinal Vascular Occlusion.

Pathways for genes affiliated with Retinal Vascular Occlusion

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Sources:
53Reactome, 52R&D Systems, 37NCBI BioSystems Database, 51QIAGEN
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Pathways related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.5SERPINC1, F5
2
Hide members
9.5SERPINC1, F5
39.3SERPINC1, VEGFA
4
Hide members
9.1SELP, VEGFA, F5

Compounds for genes affiliated with Retinal Vascular Occlusion

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 101)
idCompoundScoreTop Affiliating Genes
1phosphatidylserine44 28 1112.0APOH, RHO
2uric acid44 2411.0F5, APOH
3inogatran449.9SERPINC1, F5
4batroxobin449.8SELP, F5
5ecarin449.8F5, SERPINC1
6kaolin449.8APOH, F5
7hirugen449.8F5, SERPINC1
8spectrozyme449.8F5, SERPINC1
9nafamostat mesilate449.7F5, SERPINC1
10fluorescein44 1110.7SERPINC1, VEGFA
11danaparoid449.7F5, SERPINC1
12eltrombopag49 1110.7SERPINC1, F5
13sarpogrelate hydrochloride449.7SERPINC1, SELP
14ximelagatran44 1110.7SERPINC1, F5
15nadroparin44 1110.6SERPINC1, SELP
16ancrod449.6F5, SERPINC1
17halothane44 28 1111.5F5, RHO, SELP
18tyrosine sulfate449.5SELP, F5
19heparinoids449.5F5, SERPINC1
20bivalirudin44 1110.4SELP, F5, SERPINC1
21argatroban44 1110.4SERPINC1, F5, SELP
22warfarin44 49 11 2412.4APOH, SERPINC1, SELP
23ristocetin449.4SERPINC1, F5, SELP
24Alpha-D-Mannose119.4APOH, RHO, SERPINC1
25desmopressin44 59 28 1112.4F5, SERPINC1, SELP
26hirudin449.4SELP, F5, SERPINC1
27ticlopidine44 1110.4SELP, APOH, SERPINC1
28protamine449.4F5, SERPINC1, SELP
29dermatan sulfate449.4SERPINC1, SELP, F5
30vitamin b12449.3MTHFR, F5, APOH
31aprotinin44 1110.3F5, SELP, SERPINC1
32Dalteparin119.3VEGFA, SELP, SERPINC1
33progestin449.2F5, SERPINC1, VEGFA
34fondaparinux449.2SERPINC1, F5
35betacarotene449.2RHO, MTHFR, APOH
36atorvastatin44 49 28 11 2413.1SELP, VEGFA, F5
37dextran sulfate449.1F5, APOH, SELP, SERPINC1
38kininogen449.0APOH, F5, SERPINC1, SELP
39cyclophosphamide44 49 1110.9PIGA, MTHFR, F5, APOH
40polysaccharide448.9SELP, SERPINC1, RHO, F5
41folate448.7F5, MTHFR, SERPINC1, APOH
42arginine448.5SELP, SERPINC1, F5, RHO, APOH
43homocysteine44 249.2MTHFR, APOH, SERPINC1, SELP, F5
44aspirin44 49 28 2411.2MTHFR, SELP, F5, APOH, SERPINC1
45heparin44 28 11 2411.2SELP, RHO, MTHFR, APOH, VEGFA
46fibrinogen448.2APOH, F5, MTHFR, SELP, SERPINC1
47creatinine448.2F5, MTHFR, SELP, SERPINC1, APOH
48prostacyclin448.1VEGFA, F5, RHO, SELP, SERPINC1, APOH
49vegf448.1F5, APOH, RHO, VEGFA, SELP, SERPINC1
50estrogen447.7SERPINC1, SELP, VEGFA, MTHFR, F5, APOH

GO Terms for genes affiliated with Retinal Vascular Occlusion

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16Gene Ontology
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Cellular components related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.6VEGFA, F5
2extracellular spaceGO:0056157.8SERPINC1, SELP, VEGFA, F5, APOH

Biological processes related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte migrationGO:0026879.4SELP, VEGFA
2blood circulationGO:0080159.3MTHFR, F5
3platelet degranulationGO:0025769.2SELP, VEGFA, F5
4platelet activationGO:0301688.8SELP, VEGFA, F5
5blood coagulationGO:0075968.4F5, VEGFA, SELP, SERPINC1

Molecular functions related to Retinal Vascular Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glycoprotein bindingGO:0019489.3SELP, APOH
2heparin bindingGO:0082018.3SERPINC1, SELP, VEGFA, APOH
3protein bindingGO:0055157.2PIGA, F5, RHO, VEGFA, SELP, SERPINC1

Products for genes affiliated with Retinal Vascular Occlusion

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  • Antibodies
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Sources for Retinal Vascular Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet