MCID: RTN001
MIFTS: 43

Retinal Vasculitis

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vasculitis

MalaCards integrated aliases for Retinal Vasculitis:

Name: Retinal Vasculitis 12 52 42 14 69
Retinal Vasculitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD10 33 H35.06
ICD9CM 35 362.18
MeSH 42 D031300
SNOMED-CT 64 193367006 77628002
UMLS 69 C0152026

Summaries for Retinal Vasculitis

MalaCards based summary : Retinal Vasculitis, also known as retinal vasculitis nos, is related to pulmonary tuberculosis and irvan syndrome, and has symptoms including eye manifestations An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll-like Receptor Signaling Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia : 72 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
id Related Disease Score Top Affiliating Genes
1 pulmonary tuberculosis 29.2 CCL2 IFNB1
2 irvan syndrome 11.7
3 eales disease 11.2
4 vasculitis 10.8
5 retinitis 10.8
6 aneurysm 10.3
7 neuroretinitis 10.3
8 cryptosporidiosis 10.3 APOH CCL2
9 uveitis 10.2
10 brown's tendon sheath syndrome 10.1 APOH NOS2
11 sacrococcygeal teratoma 10.1 APOH CCL2
12 dermatitis herpetiformis, familial 10.1 APOH CCL2
13 bell's palsy 10.1 IFNB1 SOD1
14 ostertagiasis 10.0 CCL2 IFNB1
15 lupus erythematosus 10.0
16 systemic lupus erythematosus 10.0
17 cataract 10.0
18 tuberculosis 10.0
19 back pain 10.0 NOS2 SOD1
20 choroiditis 9.9
21 endophthalmitis 9.9
22 retinal vein occlusion 9.8
23 anterior uveitis 9.8
24 scleritis 9.8
25 lymphoma 9.8
26 mixed connective tissue disease 9.8
27 arthritis 9.8
28 crohn's disease 9.8
29 syphilis 9.8
30 rheumatoid arthritis 9.8
31 connective tissue disease 9.8
32 ragweed sensitivity 9.8 CCL2 NOS2
33 intermediate uveitis 9.8
34 acute posterior multifocal placoid pigment epitheliopathy 9.8
35 leukemia 9.8
36 chickenpox 9.8
37 neuropathy 9.8
38 neuritis 9.8
39 melanoma 9.8
40 endotheliitis 9.8
41 central retinal vein occlusion 9.8
42 polyarteritis nodosa 9.8
43 west nile virus 9.8
44 optic neuritis 9.8
45 multiple myeloma 9.7
46 t-cell leukemia 9.7
47 allergic encephalomyelitis 9.7
48 antiphospholipid syndrome 9.7
49 retinal artery occlusion 9.7
50 neovascular glaucoma 9.7

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

GenomeRNAi Phenotypes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 NOS2 CX3CR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 NOS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.64 NOS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 NOS2 APOH CX3CR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CX3CR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 CX3CR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.64 CX3CR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.64 NOS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NOS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 NOS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 APOH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 APOH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.64 CX3CR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 NOS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 APOH CX3CR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 NOS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 NOS2

MGI Mouse Phenotypes related to Retinal Vasculitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 APOH CX3CR1 IFNB1 NOS2 SAG SOD1
2 immune system MP:0005387 9.63 NOS2 SOD1 TLR3 CCL2 CX3CR1 IFNB1
3 neoplasm MP:0002006 9.26 IFNB1 NOS2 SOD1 TLR3
4 nervous system MP:0003631 9.1 CX3CR1 IFNB1 NOS2 SAG SOD1 TLR3

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
13 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
16 Prednisolone acetate Phase 4,Phase 3,Phase 2
17 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
18 Prednisolone phosphate Phase 4,Phase 3,Phase 2
19 Protective Agents Phase 4
20 Adrenocorticotropic Hormone Phase 4
21 beta-endorphin Phase 4
22 Melanocyte-Stimulating Hormones Phase 4
23
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
24
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
25 Antifungal Agents Phase 3
26 Anti-Infective Agents Phase 3,Phase 1,Phase 2
27 Antirheumatic Agents Phase 3,Phase 2,Phase 1
28 Antiviral Agents Phase 3
29 Calcineurin Inhibitors Phase 3
30 Cyclosporins Phase 3
31 Dermatologic Agents Phase 3,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Interferon-alpha Phase 3
34 interferons Phase 3
35 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
36 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
37
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
38
Azathioprine Approved Phase 2 446-86-6 2265
39
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
40
rituximab Approved Phase 2 174722-31-7 10201696
41
Daclizumab Approved, Investigational Phase 2 152923-56-3
42
Benzocaine Approved Phase 2 1994-09-7, 94-09-7 2337
43
Ustekinumab Approved, Investigational Phase 2 815610-63-0
44
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
45 tannic acid Approved, Nutraceutical Phase 2
46 Analgesics Phase 2,Phase 1
47 Analgesics, Non-Narcotic Phase 2,Phase 1
48 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
49 Antibodies Phase 2
50 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 15)

id Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
4 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
5 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
6 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2 Rituximab;Cytotoxic Combination
7 HAT in Eye Complications of Behcet's Disease Completed NCT00001865 Phase 2 Daclizumab
8 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
9 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Not yet recruiting NCT02648581 Phase 2 Subcutaneous Ustekinumab
10 Apremilast in the Treatment of Uveitis Terminated NCT00889421 Phase 1, Phase 2 Apremilast
11 Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Terminated NCT00550498 Phase 1
12 Optical Coherence Tomography (OCT) in Retinal Vasculitis Unknown status NCT01998464
13 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Etanercept, Methotrexate, Prednisolone
14 Biological Markers in Retinal Vasculitis Completed NCT00050492
15 Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography Not yet recruiting NCT03264391

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

39
Eye, T Cells, Endothelial, Testes, Retina, Skin, Pituitary

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 349)
id Title Authors Year
1
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. ( 28724375 )
2017
2
Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis. ( 28810044 )
2017
3
Case of combination therapy to treat lupus retinal vasculitis refractory to steroids. ( 28237161 )
2017
4
A New Complication Associated with the Use of Prophylactic Intracameral Antibiotics: Hemorrhagic Occlusive Retinal Vasculitis. ( 28433121 )
2017
5
Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis. ( 28263735 )
2017
6
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease. ( 28937479 )
2017
7
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
8
Intracameral Antibiotics in the Shadow of Hemorrhagic Occlusive Retinal Vasculitis. ( 28433122 )
2017
9
Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography. ( 28844053 )
2017
10
Clinical Features and Incidence Rates of Ocular Complications in Patients With Retinal Vasculitis. ( 28501390 )
2017
11
Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes. ( 28110950 )
2017
12
RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA. ( 27820753 )
2017
13
Hemorrhagic occlusive retinal vasculitis after inadvertent intraocular perforation with gentamycin injection. ( 28233891 )
2017
14
Multimodal Imaging in Retinal Vasculitis. ( 28696172 )
2017
15
Ultra-widefield fundus fluorescein angiography in the diagnosis and management of retinal vasculitis. ( 28574499 )
2017
16
Acute Bilateral Retinal Vasculitis Revealing a Serotonin-Secreting Neuroendocrine Neoplasm. ( 28291162 )
2017
17
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
18
New imaging techniques in retinal vasculitis. ( 28687121 )
2017
19
Characterization of isolated retinal vasculitis. Analysis of a cohort from a single center and literature review. ( 28137481 )
2017
20
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. ( 28816862 )
2017
21
Bilateral Branch Occlusive Retinal Vasculitis Induced by Septic Embo-lism in Endogenous Klebsiella Endo-phthalmitis. ( 28367048 )
2017
22
Acute necrotizing retinal vasculitis as onset of systemic lupus erythematosus: A case report. ( 28079801 )
2017
23
Bilateral Ischemic Retinal Vasculitis in Metastatic Cutaneous Melanoma Patient Treated with Dabrafenib and Trametinib: A Case Report. ( 27973971 )
2016
24
Inter-observer Variability in Scoring Ultra-wide-field Fluorescein Angiography in Patients with BehAset Retinal Vasculitis. ( 27230121 )
2016
25
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
26
PERIPHERAL RETINAL VASCULITIS: Analysis of 110 Consecutive Cases and a Contemporary Reappraisal of Tubercular Etiology. ( 27491042 )
2016
27
Retinal vasculitis. ( 26945335 )
2016
28
MICROVASCULAR FLOW ABNORMALITIES ASSOCIATED WITH RETINAL VASCULITIS: A Potential of Mechanism of Retinal Injury. ( 27759582 )
2016
29
Bilateral neovascular glaucoma in idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. ( 27085273 )
2016
30
MACULA RETINAL VASCULITIS AND CHOROIDITIS ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGIITIS. ( 27305849 )
2016
31
Retinal Vasculitis in Patients with Systemic Lupus Erythematosus. ( 27726473 )
2016
32
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AND NONHEMORRHAGIC VASCULITIS AFTER UNCOMPLICATED CATARACT SURGERY WITH INTRACAMERAL VANCOMYCIN. ( 27552119 )
2016
33
Retinal vasculitis associated with autoantibodies of primary SjAPgren's syndrome after cataract surgery. ( 26875858 )
2016
34
A case report of Epstein-Barr virus-associated retinal vasculitis: successful treatment using only acyclovir therapy. ( 27524923 )
2016
35
POSTOPERATIVE HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS: A FORME FRUSTE VARIANT? ( 28045863 )
2016
36
Retinal Vasculitis in Anti-Synthetase Syndrome. ( 27631486 )
2016
37
Bilateral retinal vasculitis in a patient with lichen planus. ( 28076570 )
2016
38
Acute multifocal hemorrhagic retinal vasculitis in a child: a case report. ( 27756269 )
2016
39
Haemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin during cataract surgery. ( 26946326 )
2016
40
Bilateral Scleritis and Retinal Vasculitis in Microscopic Polyangiitis. ( 27871395 )
2016
41
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS. ( 27533640 )
2016
42
Fluorescein Photodiagnosis of Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) Syndrome: A Case Report and Long-Term Outcome of Photocoagulation Therapy. ( 27491854 )
2016
43
Canadian Retina Society ocular safety and therapeutics update: hemorrhagic occlusive retinal vasculitis. ( 27316278 )
2016
44
Adaptive Optics Imaging in Retinal Vasculitis. ( 28010147 )
2016
45
Hemorrhagic Occlusive Retinal Vasculitis After First Eye Cataract Surgery Without Subsequent Second Eye Involvement. ( 27548454 )
2016
46
Postoperative hemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin prophylaxis duringA cataract surgery. ( 27956296 )
2016
47
Vanishing retinal arterial aneurysms with anti-tubercular treatment in a patient presenting with idiopathic retinal vasculitis, aneurysms, and neuroretinitis. ( 26922651 )
2016
48
Occlusive retinal vasculitis secondary to BehAset's disease. ( 27489374 )
2016
49
VISUAL OUTCOME AND POOR PROGNOSTIC FACTORS IN ISOLATED IDIOPATHIC RETINAL VASCULITIS. ( 26991648 )
2016
50
SCLEROMYXEDEMA WITH RETINAL VASCULITIS AND MACULAR EDEMA. ( 27348792 )
2016

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

GO Terms for Retinal Vasculitis

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 CCL2 IFNB1 SAG
2 defense response to bacterium GO:0042742 9.71 IFNB1 NOS2 TLR3
3 cellular response to lipopolysaccharide GO:0071222 9.63 CCL2 CX3CR1 NOS2
4 humoral immune response GO:0006959 9.61 CCL2 IFNB1
5 response to heat GO:0009408 9.6 CCL2 SOD1
6 positive regulation of tumor necrosis factor production GO:0032760 9.59 CCL2 TLR3
7 response to antibiotic GO:0046677 9.58 CCL2 SOD1
8 cellular response to dexamethasone stimulus GO:0071549 9.57 CCL2 IFNB1
9 response to bacterium GO:0009617 9.56 CCL2 NOS2
10 response to exogenous dsRNA GO:0043330 9.55 IFNB1 TLR3
11 positive regulation of cytokine production GO:0001819 9.52 SOD1 TLR3
12 superoxide metabolic process GO:0006801 9.51 NOS2 SOD1
13 negative regulation of angiogenesis GO:0016525 9.5 APOH CCL2 CX3CR1
14 cellular response to exogenous dsRNA GO:0071360 9.49 IFNB1 TLR3
15 cellular response to interferon-beta GO:0035458 9.48 IFNB1 TLR3
16 macrophage chemotaxis GO:0048246 9.43 CCL2 CX3CR1
17 cellular response to drug GO:0035690 9.43 CCL2 NOS2 TLR3
18 cellular response to ATP GO:0071318 9.4 CCL2 SOD1
19 cellular response to dsRNA GO:0071359 9.37 IFNB1 TLR3
20 cellular response to interferon-gamma GO:0071346 9.33 CCL2 NOS2 TLR3
21 microglial cell activation involved in immune response GO:0002282 8.96 CX3CR1 TLR3
22 positive regulation of leukocyte mediated cytotoxicity GO:0001912 8.62 CCL2 NOS2

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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