MCID: RTN001
MIFTS: 44

Retinal Vasculitis malady

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vasculitis

Aliases & Descriptions for Retinal Vasculitis:

Name: Retinal Vasculitis 12 52 42 14 69
Retinal Vasculitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD10 33 H35.06
ICD9CM 35 362.18
MeSH 42 D031300
SNOMED-CT 64 193367006 77628002
UMLS 69 C0152026

Summaries for Retinal Vasculitis

MalaCards based summary : Retinal Vasculitis, also known as retinal vasculitis nos, is related to tuberculosis and irvan syndrome, and has symptoms including eye manifestations An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll-like Receptor Signaling Pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia : 71 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 tuberculosis 30.1 CCL2 IFNB1
2 irvan syndrome 11.7
3 eales disease 11.2
4 vasculitis 10.8
5 retinitis 10.8
6 aneurysm 10.3
7 neuroretinitis 10.3
8 uveitis 10.2
9 cryptosporidiosis 10.1 APOH CCL2
10 exhibitionism 10.1 APOH NOS2
11 scar contracture 10.1 APOH CCL2
12 stiff-person syndrome 10.1 APOH CCL2
13 systemic lupus erythematosus 10.0
14 lupus erythematosus 10.0
15 proximal symphalangism 10.0 CCL2 IFNB1
16 central cord syndrome 10.0 NOS2 SOD1
17 bell's palsy 10.0 IFNB1 SOD1
18 cataract 10.0
19 placental choriocarcinoma 10.0 CCL2 CX3CR1
20 baritosis 10.0 CCL2 SOD1
21 sexual masochism 9.9 IFNB1 TLR3
22 ectodermal dysplasia bartalos type 9.9 NOS2 SAG SOD1
23 advanced sleep phase syndrome, familial, 1 9.9 CCL2 IFNB1 NOS2
24 hyperimmunoglobulin syndrome 9.9 CCL2 IFNB1
25 choroiditis 9.9
26 endophthalmitis 9.9
27 rheumatoid arthritis 9.8
28 retinal vein occlusion 9.8
29 anterior uveitis 9.8
30 lymphoma 9.8
31 arthritis 9.8
32 crohn's disease 9.8
33 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 9.8 CCL2 CX3CR1 TLR3
34 endotheliitis 9.8
35 central retinal vein occlusion 9.8
36 polyarteritis nodosa 9.8
37 intermediate uveitis 9.8
38 connective tissue disease 9.8
39 leukemia 9.8
40 acute posterior multifocal placoid pigment epitheliopathy 9.8
41 scleritis 9.8
42 mixed connective tissue disease 9.8
43 chickenpox 9.8
44 melanoma 9.8
45 syphilis 9.8
46 pericarditis 9.7 APOH CCL2 NOS2 SOD1
47 substance-induced psychosis 9.7 CCL2 IFNB1 NOS2 SOD1
48 panuveitis 9.7
49 optic neuritis 9.7
50 toxoplasmosis 9.7

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

GenomeRNAi Phenotypes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 NOS2 CX3CR1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 NOS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.64 NOS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 CX3CR1 NOS2 APOH
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CX3CR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 CX3CR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.64 CX3CR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.64 NOS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NOS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 NOS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 APOH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 APOH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.64 CX3CR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 NOS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 APOH CX3CR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 NOS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 NOS2

MGI Mouse Phenotypes related to Retinal Vasculitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 APOH CX3CR1 IFNB1 NOS2 SAG SOD1
2 immune system MP:0005387 9.63 CX3CR1 IFNB1 NOS2 SOD1 TLR3 CCL2
3 neoplasm MP:0002006 9.26 IFNB1 NOS2 SOD1 TLR3
4 nervous system MP:0003631 9.1 CX3CR1 IFNB1 NOS2 SAG SOD1 TLR3

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4,Phase 1,Phase 2
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
13 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
16 Prednisolone acetate Phase 4,Phase 3,Phase 2
17 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
18 Prednisolone phosphate Phase 4,Phase 3,Phase 2
19 Protective Agents Phase 4
20 Adrenocorticotropic Hormone Phase 4
21 beta-endorphin Phase 4
22 Melanocyte-Stimulating Hormones Phase 4
23
Cyclosporine Approved, Investigational, Vet_approved Phase 3 79217-60-0, 59865-13-3 5284373 6435893
24
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
25
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
26 Antifungal Agents Phase 3
27 Anti-Infective Agents Phase 3,Phase 1,Phase 2
28 Antirheumatic Agents Phase 3,Phase 2,Phase 1
29 Antiviral Agents Phase 3
30 Calcineurin Inhibitors Phase 3
31 Dermatologic Agents Phase 3,Phase 1,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Interferon-alpha Phase 3
34 interferons Phase 3
35 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
36 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
37
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
38
Azathioprine Approved Phase 2 446-86-6 2265
39
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
40
rituximab Approved Phase 2 174722-31-7 10201696
41
Daclizumab Approved, Investigational Phase 2 152923-56-3
42
Infliximab Approved Phase 1, Phase 2 170277-31-3
43
Ustekinumab Approved, Investigational Phase 2 815610-63-0
44
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
45 Analgesics Phase 2,Phase 1
46 Analgesics, Non-Narcotic Phase 2,Phase 1
47 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
48 Antibodies Phase 2
49 Antibodies, Monoclonal Phase 2
50 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4
3 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Not yet recruiting NCT03066869 Phase 4
4 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3
5 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3
6 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2
7 HAT in Eye Complications of Behcet's Disease Completed NCT00001865 Phase 2
8 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2
9 Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study Completed NCT02620618 Phase 1, Phase 2
10 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Not yet recruiting NCT02648581 Phase 2
11 Apremilast in the Treatment of Uveitis Terminated NCT00889421 Phase 1, Phase 2
12 Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Terminated NCT00550498 Phase 1
13 Optical Coherence Tomography (OCT) in Retinal Vasculitis Unknown status NCT01998464
14 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957
15 Biological Markers in Retinal Vasculitis Completed NCT00050492
16 Interest of Medical Imaging in the Diagnostic Strategy Vis a Vis a Suspected Horton Disease Recruiting NCT02473029
17 Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Recruiting NCT01793168
18 Clinical and Molecular Investigations Into Ciliopathies Active, not recruiting NCT00068224

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

39
Eye, T Cells, Endothelial, Testes, Retina, Skin, Pituitary

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 329)
id Title Authors Year
1
RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA. ( 27820753 )
2017
2
Acute necrotizing retinal vasculitis as onset of systemic lupus erythematosus: A case report. ( 28079801 )
2017
3
Postoperative hemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin prophylaxis duringA cataract surgery. ( 27956296 )
2016
4
MICROVASCULAR FLOW ABNORMALITIES ASSOCIATED WITH RETINAL VASCULITIS: A Potential of Mechanism of Retinal Injury. ( 27759582 )
2016
5
Adaptive Optics Imaging in Retinal Vasculitis. ( 28010147 )
2016
6
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS. ( 27533640 )
2016
7
Fluorescein Photodiagnosis of Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis (IRVAN) Syndrome: A Case Report and Long-Term Outcome of Photocoagulation Therapy. ( 27491854 )
2016
8
Canadian Retina Society ocular safety and therapeutics update: hemorrhagic occlusive retinal vasculitis. ( 27316278 )
2016
9
Vanishing retinal arterial aneurysms with anti-tubercular treatment in a patient presenting with idiopathic retinal vasculitis, aneurysms, and neuroretinitis. ( 26922651 )
2016
10
A case report of Epstein-Barr virus-associated retinal vasculitis: successful treatment using only acyclovir therapy. ( 27524923 )
2016
11
Retinal vasculitis associated with autoantibodies of primary SjAPgren's syndrome after cataract surgery. ( 26875858 )
2016
12
RETINAL VASCULITIS ASSOCIATED WITH EPSTEIN-BARR VIRUS INFECTION, A CASE REPORT. ( 28030457 )
2016
13
Occlusive retinal vasculitis secondary to BehAset's disease. ( 27489374 )
2016
14
MACULA RETINAL VASCULITIS AND CHOROIDITIS ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGIITIS. ( 27305849 )
2016
15
HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS AND NONHEMORRHAGIC VASCULITIS AFTER UNCOMPLICATED CATARACT SURGERY WITH INTRACAMERAL VANCOMYCIN. ( 27552119 )
2016
16
Bilateral Scleritis and Retinal Vasculitis in Microscopic Polyangiitis. ( 27871395 )
2016
17
SCLEROMYXEDEMA WITH RETINAL VASCULITIS AND MACULAR EDEMA. ( 27348792 )
2016
18
Retinal Vasculitis in Patients with Systemic Lupus Erythematosus. ( 27726473 )
2016
19
Bilateral Ischemic Retinal Vasculitis in Metastatic Cutaneous Melanoma Patient Treated with Dabrafenib and Trametinib: A Case Report. ( 27973971 )
2016
20
Haemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin during cataract surgery. ( 26946326 )
2016
21
Inter-observer Variability in Scoring Ultra-wide-field Fluorescein Angiography in Patients with BehAset Retinal Vasculitis. ( 27230121 )
2016
22
VISUAL OUTCOME AND POOR PROGNOSTIC FACTORS IN ISOLATED IDIOPATHIC RETINAL VASCULITIS. ( 26991648 )
2016
23
Bilateral retinal vasculitis in a patient with lichen planus. ( 28076570 )
2016
24
Retinal Vasculitis in Anti-Synthetase Syndrome. ( 27631486 )
2016
25
Hemorrhagic Occlusive Retinal Vasculitis After First Eye Cataract Surgery Without Subsequent Second Eye Involvement. ( 27548454 )
2016
26
POSTOPERATIVE HEMORRHAGIC OCCLUSIVE RETINAL VASCULITIS: A FORME FRUSTE VARIANT? ( 28045863 )
2016
27
Retinal vasculitis. ( 26945335 )
2016
28
Churg-Strauss syndrome associated with antiphospholipid antibodies in a patient with retinal vasculitis. ( 27068137 )
2016
29
Small-Caliber Retinal Vasculitis Associated With Giant Cell Arteritis: A New Finding. ( 27842201 )
2016
30
PERIPHERAL RETINAL VASCULITIS: Analysis of 110 Consecutive Cases and a Contemporary Reappraisal of Tubercular Etiology. ( 27491042 )
2016
31
Acute multifocal hemorrhagic retinal vasculitis in a child: a case report. ( 27756269 )
2016
32
Eosinophilic Granulomatosis with Polyangiitis Presenting with Skin Rashes, Eosinophilic Cholecystitis, and Retinal Vasculitis. ( 27857032 )
2016
33
Bilateral neovascular glaucoma in idiopathic retinal vasculitis, aneurysms, and neuroretinitis syndrome. ( 27085273 )
2016
34
Correlation between Fluorescein Angiographic Findings and Visual Acuity in BehAset Retinal Vasculitis. ( 26069134 )
2015
35
Case report: an 11-year-old girl presenting with asymptomatic retinal vasculitis leading to diagnosis of HIV-1 infection. ( 26372396 )
2015
36
Optical Coherence Tomography Features in Idiopathic Retinal Vasculitis, Aneurysms and Neuroretinitis Syndrome. ( 26425325 )
2015
37
CHARACTERISTICS AND LONG-TERM OUTCOME OF PATIENTS WITH NONINFECTIOUS RETINAL VASCULITIS. ( 26035402 )
2015
38
A rare case of idiopathic retinal vasculitis, aneurysms and neuroretinitis (IRVAN) syndrome. ( 26265851 )
2015
39
Anterior and Intermediate Uveitis with Retinal Vasculitis: An Unusual Manifestation of Post-Streptococcal Uveitis Syndrome. ( 26713592 )
2015
40
Long-term follow-up of herpetic non-necrotizing retinopathy with occlusive retinal vasculitis and neovascularization. ( 25861397 )
2015
41
Systemic lupus erythematosus and antiphospholipid syndrome related retinal vasculitis mimicking ocular cysticercosis: a case report. ( 25837363 )
2015
42
LONG-TERM EFFICACY OF SYSTEMIC INFLIXIMAB IN RECALCITRANT RETINAL VASCULITIS. ( 26200508 )
2015
43
Postoperative Hemorrhagic Occlusive Retinal Vasculitis: Expanding the Clinical Spectrum and Possible Association with Vancomycin. ( 25886796 )
2015
44
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome. ( 26441263 )
2015
45
SEVERE PANUVEITIS, RETINAL VASCULITIS, AND OPTIC DISK GRANULOMA SECONDARY TO SARCOIDOSIS. ( 26650564 )
2015
46
Ischemic Retinal Vasculitis Associated with Cataract Surgery and Intracameral Vancomycin. ( 26618015 )
2015
47
Retinal Vasculitis in Kawasaki Disease. ( 25990595 )
2015
48
Klebsiella Endophthalmitis as Retinal Vasculitis with Prostatic Abscess. ( 26017191 )
2015
49
Bilateral vaso-occlusive retinal vasculitis with h1n1 influenza a infection. ( 25423042 )
2015
50
Ocular ischemic syndrome presenting as retinal vasculitis in a patient with moyamoya syndrome. ( 25799075 )
2015

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

GO Terms for Retinal Vasculitis

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 22)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.76 CCL2 IFNB1 SAG
2 defense response to bacterium GO:0042742 9.71 IFNB1 NOS2 TLR3
3 humoral immune response GO:0006959 9.61 CCL2 IFNB1
4 response to heat GO:0009408 9.6 CCL2 SOD1
5 positive regulation of tumor necrosis factor production GO:0032760 9.59 CCL2 TLR3
6 cellular response to dexamethasone stimulus GO:0071549 9.58 CCL2 IFNB1
7 cellular response to lipopolysaccharide GO:0071222 9.58 CCL2 CX3CR1 NOS2
8 response to bacterium GO:0009617 9.57 CCL2 NOS2
9 response to antibiotic GO:0046677 9.56 CCL2 SOD1
10 response to exogenous dsRNA GO:0043330 9.55 IFNB1 TLR3
11 positive regulation of cytokine production GO:0001819 9.52 SOD1 TLR3
12 superoxide metabolic process GO:0006801 9.51 NOS2 SOD1
13 cellular response to drug GO:0035690 9.5 CCL2 NOS2 TLR3
14 cellular response to interferon-beta GO:0035458 9.49 IFNB1 TLR3
15 cellular response to ATP GO:0071318 9.48 CCL2 SOD1
16 macrophage chemotaxis GO:0048246 9.46 CCL2 CX3CR1
17 cellular response to exogenous dsRNA GO:0071360 9.43 IFNB1 TLR3
18 negative regulation of angiogenesis GO:0016525 9.43 APOH CCL2 CX3CR1
19 cellular response to dsRNA GO:0071359 9.37 IFNB1 TLR3
20 cellular response to interferon-gamma GO:0071346 9.33 CCL2 NOS2 TLR3
21 positive regulation of leukocyte mediated cytotoxicity GO:0001912 8.96 CCL2 NOS2
22 microglial cell activation involved in immune response GO:0002282 8.62 CX3CR1 TLR3

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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