MCID: RTN001
MIFTS: 47

Retinal Vasculitis

Categories: Cardiovascular diseases, Eye diseases

Aliases & Classifications for Retinal Vasculitis

MalaCards integrated aliases for Retinal Vasculitis:

Name: Retinal Vasculitis 12 51 41 14 69
Retinal Vasculitis Nos 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11563
ICD10 32 H35.06
ICD9CM 34 362.18
MeSH 41 D031300
SNOMED-CT 64 193367006 77628002
UMLS 69 C0152026

Summaries for Retinal Vasculitis

MalaCards based summary : Retinal Vasculitis, also known as retinal vasculitis nos, is related to eales disease and retinal vein occlusion, and has symptoms including eye manifestations An important gene associated with Retinal Vasculitis is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Toll-Like receptor Signaling Pathways and Toll-like receptor signaling pathway. The drugs Methylprednisolone and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include eye, t cells and endothelial, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 72 Retinal vasculitis is inflammation of the vascular branches of the retinal artery, caused either by... more...

Related Diseases for Retinal Vasculitis

Diseases related to Retinal Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 eales disease 31.4 NOS2 SAG SOD1
2 retinal vein occlusion 30.1 APOH CCL2
3 retinal vascular occlusion 29.7 APOH CCL2
4 temporal arteritis 29.5 APOH CCL2
5 multiple sclerosis 28.6 CCL2 IFNB1 NOS2
6 irvan syndrome 11.8
7 retinitis 10.9
8 vasculitis 10.9
9 aneurysm 10.4
10 neuroretinitis 10.4
11 uveitis 10.2
12 degeneration of macula and posterior pole 10.1 CCL2 CX3CR1
13 systemic lupus erythematosus 10.1
14 mycobacterium tuberculosis 1 10.1
15 cataract 10.1
16 lupus erythematosus 10.1
17 choroiditis 10.0
18 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
19 scleritis 9.9
20 endophthalmitis 9.9
21 pneumoconiosis 9.9 CCL2 SOD1
22 ocular hyperemia 9.9 IFNB1 SOD1
23 severe acute respiratory syndrome 9.9 CCL2 IFNB1
24 borderline leprosy 9.9 APOH NOS2
25 japanese encephalitis 9.9 IFNB1 TLR3
26 rheumatoid arthritis 9.9
27 arthritis 9.9
28 crohn's disease 9.9
29 lymphoma 9.9
30 mixed connective tissue disease 9.9
31 syphilis 9.9
32 connective tissue disease 9.9
33 anterior uveitis 9.9
34 west nile virus 9.8
35 polyarteritis nodosa, childhood-onset 9.8
36 hydrops, lactic acidosis, and sideroblastic anemia 9.8
37 leukemia 9.8
38 optic neuritis 9.8
39 intermediate uveitis 9.8
40 neuritis 9.8
41 melanoma 9.8
42 central retinal vein occlusion 9.8
43 macular retinal edema 9.8
44 retinal artery occlusion 9.8
45 chickenpox 9.8
46 neuropathy 9.8
47 polyarteritis nodosa 9.8
48 acute posterior multifocal placoid pigment epitheliopathy 9.8
49 endotheliitis 9.8
50 peyronie disease 9.8 NOS2 SOD1

Graphical network of the top 20 diseases related to Retinal Vasculitis:



Diseases related to Retinal Vasculitis

Symptoms & Phenotypes for Retinal Vasculitis

UMLS symptoms related to Retinal Vasculitis:


eye manifestations

GenomeRNAi Phenotypes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

25 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.64 CX3CR1 NOS2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.64 NOS2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.64 NOS2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.64 NOS2 APOH CX3CR1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.64 CX3CR1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-186 9.64 CX3CR1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.64 CX3CR1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.64 NOS2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.64 NOS2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.64 NOS2
11 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.64 APOH
12 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.64 APOH
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.64 CX3CR1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.64 NOS2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.64 APOH CX3CR1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.64 NOS2
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.64 NOS2

MGI Mouse Phenotypes related to Retinal Vasculitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.8 TLR3 APOH CX3CR1 IFNB1 NOS2 SAG
2 immune system MP:0005387 9.63 SOD1 TLR3 CCL2 CX3CR1 IFNB1 NOS2
3 neoplasm MP:0002006 9.26 SOD1 TLR3 IFNB1 NOS2
4 nervous system MP:0003631 9.1 SOD1 TLR3 CX3CR1 IFNB1 NOS2 SAG

Drugs & Therapeutics for Retinal Vasculitis

Drugs for Retinal Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 69)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
2
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
3 Antiemetics Phase 4
4 Anti-Inflammatory Agents Phase 4,Phase 1,Phase 2
5 Antineoplastic Agents, Hormonal Phase 4
6 Autonomic Agents Phase 4
7 Gastrointestinal Agents Phase 4
8 glucocorticoids Phase 4
9 Hormone Antagonists Phase 4
10 Hormones Phase 4
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
12 Methylprednisolone acetate Phase 4,Phase 3,Phase 2
13 Methylprednisolone Hemisuccinate Phase 4,Phase 3,Phase 2
14 Neuroprotective Agents Phase 4
15 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 1
16 Prednisolone acetate Phase 4,Phase 3,Phase 2
17 Prednisolone hemisuccinate Phase 4,Phase 3,Phase 2
18 Prednisolone phosphate Phase 4,Phase 3,Phase 2
19 Protective Agents Phase 4
20 Adrenocorticotropic Hormone Phase 4
21 beta-endorphin Phase 4
22 Melanocyte-Stimulating Hormones Phase 4
23
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
24
Ranibizumab Approved Phase 2, Phase 3 347396-82-1 459903
25 Antifungal Agents Phase 3
26 Anti-Infective Agents Phase 3,Phase 1,Phase 2
27 Antirheumatic Agents Phase 3,Phase 2,Phase 1
28 Antiviral Agents Phase 3
29 Calcineurin Inhibitors Phase 3
30 Cyclosporins Phase 3
31 Dermatologic Agents Phase 3,Phase 2
32 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
33 Interferon-alpha Phase 3
34 interferons Phase 3
35 Angiogenesis Inhibitors Phase 2, Phase 3,Phase 1
36 Angiogenesis Modulating Agents Phase 2, Phase 3,Phase 1
37
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
38
Azathioprine Approved Phase 2 446-86-6 2265
39
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
40
rituximab Approved Phase 2 174722-31-7 10201696
41
Benzocaine Approved, Investigational Phase 2 1994-09-7, 94-09-7 2337
42
Daclizumab Approved, Investigational Phase 2 152923-56-3
43
Ustekinumab Approved, Investigational Phase 2 815610-63-0
44
Apremilast Approved, Investigational Phase 1, Phase 2 608141-41-9 11561674
45 tannic acid Approved, Nutraceutical Phase 2
46 Analgesics Phase 2,Phase 1
47 Analgesics, Non-Narcotic Phase 2,Phase 1
48 Anti-Inflammatory Agents, Non-Steroidal Phase 1, Phase 2
49 Antibodies Phase 2
50 Antibodies, Monoclonal Phase 2

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 The Efficacy of Methylprednisolone in the Treatment of Patients With Ocular Involvement in Behcet's Disease Unknown status NCT01306955 Phase 4 methylorednisolone
2 Study of H.P. ACTHAR Subcutaneous Gelatin (Gel)(Highly Purified Gel Injection) in Uveitis Patients Completed NCT02764697 Phase 4 H.P. ACTHAR SUBCUTANEOUS GEL INJECTION
3 Efficacy and Safety of H.P. ACTHAR GEL in Adults With Retinal Vasculitis Recruiting NCT03066869 Phase 4 H.P. ACTHAR GEL
4 Interferon-alpha2a Versus Cyclosporin A for Severe Ocular Behcet`s Disease (INCYTOB) Unknown status NCT00167583 Phase 3 Cyclosporin A;Interferon-alpha2a
5 Lucentis (Ranibizumab) for Eales' Disease Completed NCT00384449 Phase 2, Phase 3 Ranibizumab
6 Rituximab for the Treatment of Severe Ocular Manifestations of Behcet's Disease Completed NCT00664599 Phase 2 Rituximab;Cytotoxic Combination
7 Safety and Efficacy of AIN457 in Noninfectious Uveitis Completed NCT00685399 Phase 2 AIN457;AIN 457;AIN457
8 HAT in Eye Complications of Behcet's Disease Completed NCT00001865 Phase 2 Daclizumab
9 Efficacy and Safety of Ustekinumab, a Human Monoclonal Anti-IL-12/IL-23 Antibody, in Patients With Behçet Disease Recruiting NCT02648581 Phase 2 Subcutaneous Ustekinumab
10 Apremilast in the Treatment of Uveitis Terminated NCT00889421 Phase 1, Phase 2 Apremilast
11 Stem Cell Transplantation in Ocular Lesions of Behcet's Disease Terminated NCT00550498 Phase 1
12 Optical Coherence Tomography (OCT) in Retinal Vasculitis Unknown status NCT01998464
13 Etanercept: Single Blind Control Study in Ocular Manifestations of Behcet's Disease Unknown status NCT00931957 Etanercept, Methotrexate, Prednisolone
14 Biological Markers in Retinal Vasculitis Completed NCT00050492
15 Evaluation of Macular Vascular Changes in Behcet's Disease Using Optical Coherence Tomography Angiography Not yet recruiting NCT03264391

Search NIH Clinical Center for Retinal Vasculitis

Cochrane evidence based reviews: retinal vasculitis

Genetic Tests for Retinal Vasculitis

Anatomical Context for Retinal Vasculitis

MalaCards organs/tissues related to Retinal Vasculitis:

38
Eye, T Cells, Endothelial, Testes, Retina, Pituitary, Skin

Publications for Retinal Vasculitis

Articles related to Retinal Vasculitis:

(show top 50) (show all 366)
# Title Authors Year
1
Pathogenesis of idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) or 'idiopathic retinal arteriolar aneurysms (IRAA)' with macular star. ( 29447942 )
2018
2
Rituximab for Sight-Threatening Lupus-Related Retinal Vasculitis. ( 29059086 )
2018
3
Hemorrhagic Ischemic Retinal Vasculitis and Alopecia Areata as a Manifestation of HLA-B27. ( 29304269 )
2018
4
SjAPgren's Disease Associated with Severe Retinal Vasculitis and/or Necrotizing Scleritis: Two Cases. ( 29452446 )
2018
5
Multimodal imaging questions etiology of idiopathic retinal vasculitis, aneurysms and neuroretinitis syndrome (IRVAN syndrome). ( 29406987 )
2018
6
Vancomycin-associated hemorrhagic occlusive retinal vasculitis: a clinical-pathophysiological analysis. ( 29425799 )
2018
7
Tubercular retinal vasculitis mimicking frosted branch angiitis: a case report. ( 29356903 )
2018
8
Characteristics and visual outcome of refractory retinal vasculitis associated with antineutrophil cytoplasm antibody-associated vasculitides. ( 29258731 )
2017
9
Clinical Outcome of Retinal Vasculitis and Predictors for Prognosis of Ischemic Retinal Vasculitis. ( 28263735 )
2017
10
Bilateral idiopathic retinal vasculitis following coxsackievirus A4 infection: a case report. ( 28724375 )
2017
11
Idiopathic Retinal Vasculitis, Aneurysms, and Neuroretinitis Syndrome Presenting With Branch Retinal Artery Occlusion. ( 29121367 )
2017
12
Retinal and Choroidal Detachment in Antineutrophil Cytoplasmic Antibody-Associated Scleritis and Retinal Vasculitis Mimicking Choroidal Tumor. ( 28489623 )
2017
13
Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male. ( 28936058 )
2017
14
New imaging techniques in retinal vasculitis. ( 28687121 )
2017
15
Ultra-wide imaging in a case of retinal vasculitis with macular star. ( 29054905 )
2017
16
Acute Bilateral Retinal Vasculitis Revealing a Serotonin-Secreting Neuroendocrine Neoplasm. ( 28291162 )
2017
17
Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography. ( 28844053 )
2017
18
Retinal Vasculitis and Choroidopathy in Pediatric-Onset Mixed Connective Tissue Disease. ( 28937479 )
2017
19
Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: Clinical Characteristics of 36 Eyes. ( 28110950 )
2017
20
TREATMENT OF IDIOPATHIC RETINAL VASCULITIS, ANEURYSMS, AND NEURORETINITIS (IRVAN) WITH PHOTOCOAGULATION IN COMBINATION WITH SYSTEMIC IMMUNOSUPPRESSION. ( 29261555 )
2017
21
Intracameral Antibiotics in the Shadow of Hemorrhagic Occlusive Retinal Vasculitis. ( 28433122 )
2017
22
RETINAL VASCULITIS ASSOCIATED WITH NEUROMYELITIS OPTICA. ( 27820753 )
2017
23
Bilateral Branch Occlusive Retinal Vasculitis Induced by Septic Embo-lism in Endogenous Klebsiella Endo-phthalmitis. ( 28367048 )
2017
24
Case of combination therapy to treat lupus retinal vasculitis refractory to steroids. ( 28237161 )
2017
25
Multimodal Imaging in Retinal Vasculitis. ( 28696172 )
2017
26
Intravitreal bevacizumab in treatment of retinal neovascularization from tuberculous retinal vasculitis. ( 29062788 )
2017
27
Ultra-widefield fundus fluorescein angiography in the diagnosis and management of retinal vasculitis. ( 28574499 )
2017
28
Retinal Vasculitis Is Principally a Single-Organ Vasculitis of the Eye. ( 29280823 )
2017
29
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. ( 28816862 )
2017
30
Idiopathic retinal vasculitis, aneurysms, and neuroretinitis (IRVAN) syndrome: clinical perspectives. ( 29062224 )
2017
31
Acute necrotizing retinal vasculitis as onset of systemic lupus erythematosus: A case report. ( 28079801 )
2017
32
Characterization of isolated retinal vasculitis. Analysis of a cohort from a single center and literature review. ( 28137481 )
2017
33
Early anti-VEGF treatment for hemorrhagic occlusive retinal vasculitis as a complication of cataract surgery. ( 29212481 )
2017
34
Retinal vasculitis associated with cutaneous leukocytoclastic vasculitis. ( 29256164 )
2017
35
Review of people with retinal vasculitis and positive QuantiFERON<sup>Ar</sup>-TB Gold test in an area nonendemic for tuberculosis. ( 29027603 )
2017
36
Hemorrhagic occlusive retinal vasculitis after inadvertent intraocular perforation with gentamycin injection. ( 28233891 )
2017
37
A New Complication Associated with the Use of Prophylactic Intracameral Antibiotics: Hemorrhagic Occlusive Retinal Vasculitis. ( 28433121 )
2017
38
Clinical Features and Incidence Rates of Ocular Complications in Patients With Retinal Vasculitis. ( 28501390 )
2017
39
Swept-Source Optical Coherence Tomography Angiography in West Nile Virus Chorioretinitis and Associated Occlusive Retinal Vasculitis. ( 28810044 )
2017
40
VISUAL OUTCOME AND POOR PROGNOSTIC FACTORS IN ISOLATED IDIOPATHIC RETINAL VASCULITIS. ( 26991648 )
2016
41
Vanishing retinal arterial aneurysms with anti-tubercular treatment in a patient presenting with idiopathic retinal vasculitis, aneurysms, and neuroretinitis. ( 26922651 )
2016
42
Bilateral Ischemic Retinal Vasculitis in Metastatic Cutaneous Melanoma Patient Treated with Dabrafenib and Trametinib: A Case Report. ( 27973971 )
2016
43
Inter-observer Variability in Scoring Ultra-wide-field Fluorescein Angiography in Patients with BehAset Retinal Vasculitis. ( 27230121 )
2016
44
ADULT WITH CHICKENPOX COMPLICATED BY SYSTEMIC VASCULITIS AND BILATERAL RETINAL VASCULITIS WITH RETINAL VASCULAR OCCLUSIONS. ( 27533640 )
2016
45
MACULA RETINAL VASCULITIS AND CHOROIDITIS ASSOCIATED WITH GRANULOMATOSIS WITH POLYANGIITIS. ( 27305849 )
2016
46
Postoperative hemorrhagic occlusive retinal vasculitis associated with intracameral vancomycin prophylaxis duringA cataract surgery. ( 27956296 )
2016
47
Bilateral retinal vasculitis in a patient with lichen planus. ( 28076570 )
2016
48
PERIPHERAL RETINAL VASCULITIS: Analysis of 110 Consecutive Cases and a Contemporary Reappraisal of Tubercular Etiology. ( 27491042 )
2016
49
Adaptive Optics Imaging in Retinal Vasculitis. ( 28010147 )
2016
50
MICROVASCULAR FLOW ABNORMALITIES ASSOCIATED WITH RETINAL VASCULITIS: A Potential of Mechanism of Retinal Injury. ( 27759582 )
2016

Variations for Retinal Vasculitis

Expression for Retinal Vasculitis

Search GEO for disease gene expression data for Retinal Vasculitis.

Pathways for Retinal Vasculitis

GO Terms for Retinal Vasculitis

Biological processes related to Retinal Vasculitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.67 CCL2 IFNB1 SAG
2 chemokine-mediated signaling pathway GO:0070098 9.54 CCL2 CX3CR1
3 cellular response to drug GO:0035690 9.52 NOS2 TLR3
4 humoral immune response GO:0006959 9.51 CCL2 IFNB1
5 response to exogenous dsRNA GO:0043330 9.48 IFNB1 TLR3
6 response to bacterium GO:0009617 9.46 CCL2 NOS2
7 positive regulation of cytokine production GO:0001819 9.43 SOD1 TLR3
8 superoxide metabolic process GO:0006801 9.4 NOS2 SOD1
9 cellular response to exogenous dsRNA GO:0071360 9.37 IFNB1 TLR3
10 cellular response to lipopolysaccharide GO:0071222 9.33 CCL2 CX3CR1 NOS2
11 cellular response to interferon-beta GO:0035458 9.32 IFNB1 TLR3
12 macrophage chemotaxis GO:0048246 9.26 CCL2 CX3CR1
13 cellular response to interferon-gamma GO:0071346 9.13 CCL2 NOS2 TLR3
14 microglial cell activation involved in immune response GO:0002282 8.62 CX3CR1 TLR3

Sources for Retinal Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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