MCID: RTN022
MIFTS: 59

Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Retinal Vein Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to central retinal vein occlusion and macular retinal edema. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Platelet Adhesion to exposed collagen and Immune response Oncostatin M signaling via JAK-Stat in human cells. The compounds warfarin and estrogen have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and integument.

Aliases & Classifications for Retinal Vein Occlusion

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

retinal vein occlusion 8 10 44 30 60
occlusion, of retinal vein 8


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Disease Ontology8 DOID:1727
MeSH34 D012170
SNOMED-CT56 46085004
NCIt39 C34981

Related Diseases for Retinal Vein Occlusion

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17GeneCards, 18GeneDecks
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Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal vein occlusion32.2PLAT, VEGFA, MTHFR, F5, APOH
2macular retinal edema31.9SERPINF1, VEGFA
3retinal vascular occlusion31.4F5, APOH
4retinal artery occlusion31.3APOH
5central retinal artery occlusion31.2PLAT
6retinal detachment31.2SERPINF1, PLAT, VEGFA
7glaucoma31.1SERPINF1, LOXL1
8hyperhomocysteinemia31.0SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
9branch retinal artery occlusion30.9F5
10hypertension30.9SERPINE1, PLAT, F2, MTHFR, F5
11retinal disease30.9SERPINF1, SERPINE1, VWF, VEGFA, ITGA2, F8
12thrombophilia30.8SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
13macular holes30.8SERPINF1
14protein s deficiency30.7SERPINC1, SERPINE1, F2, MTHFR, F5, F8
15purpura30.6SERPINC1
16ischemia30.6PLAT, VEGFA, JAK2
17vasculitis30.6F2, VWF, APOH
18hepatitis30.5F2, F8
19hepatitis c30.5F2, F8
20factor v deficiency30.5F2, F5, F8
21diabetic macular edema30.5SERPINF1, VEGFA
22antithrombin iii deficiency30.5SERPINC1, F2, MTHFR, F5, APOH
23diabetic retinopathy30.5SERPINF1, SERPINE1, VEGFA, ITGA2
24lupus erythematosus30.5SERPINC1, F2, PROCR, F5, APOH
25leukemia30.5SERPINF1, IL6, MTHFR, JAK2, F8
26systemic lupus erythematosus30.5F2, VWF, IL6, PROCR, F8, APOH
27protein c deficiency30.5SERPINC1, SERPINE1, F2, HRG, PROCR, MTHFR
28atherosclerosis30.5SERPINF1, SERPINC1, SERPINE1, PLAT, VWF, IL6
29hemolytic-uremic syndrome30.4VWF
30multiple myeloma30.4IL6
31arthritis30.4IL6
32psoriasis30.4IL6
33factor xii deficiency30.4F5
34myeloma30.4IL6, VEGFA, ITGA2, JAK2
35deficiency anemia30.4F2, VWF, IL6, JAK2, G6PD
36rheumatoid arthritis30.4HRG, IL6, VEGFA, MTHFR, ITGA2, JAK2
37pneumonia30.2IL6
38multiple sclerosis30.2IL6
39eclampsia30.2SERPINC1, MTHFR
40migraine30.2MTHFR, APOH
41cystic fibrosis30.2F8
42age related macular degeneration30.2PLAT, VEGFA
43sneddon syndrome30.2SERPINC1, APOH
44polycythemia30.2JAK2, G6PD
45sickle cell disease30.2VWF, G6PD
46polycythemia vera30.2JAK2, G6PD
47hemoglobinuria30.2G6PD
48hepatitis a30.2F2, F8
49acute leukemia30.2MTHFR, JAK2
50essential hypertension30.2SERPINE1, PLAT, VWF

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Clinical Features for Retinal Vein Occlusion

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Drugs & Therapeutics for Retinal Vein Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Search CenterWatch for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

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Anatomical Context for Retinal Vein Occlusion

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32MalaCards
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MalaCards organs/tissues related to Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Bone, Myeloid, Monocytes, Testes, Liver, Skin, Colon

Animal Models for Retinal Vein Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinal Vein Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.2G6PD, F2, SERPINF1
2MP:001077110.0LOXL1, ITGA2, VEGFA, IL6, F2
3MP:00053819.6LOXL1, VEGFA, IL6, VWF, F2, PLAT
4MP:00053899.6LOXL1, F8, MTHFR, VEGFA, SERPINC1, SERPINF1
5MP:00053789.5JAK2, F5, MTHFR, PROCR, VEGFA, IL6
6MP:00053879.4F8, JAK2, PROCR, VEGFA, IL6, VWF
7MP:00107689.3MTHFR, F5, JAK2, G6PD, F8, APOH
8MP:00053979.3F8, G6PD, JAK2, ITGA2, PROCR, VEGFA
9MP:00036319.3G6PD, F5, MTHFR, F12, VEGFA, IL6
10MP:00053768.8AQP12A, APOH, F8, G6PD, JAK2, ITGA2

Publications for Retinal Vein Occlusion

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Sources:
50PubMed
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Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 953)
idTitleAuthorsYear
1
Time to Clinically Significant Visual Acuity Gains after Ranibizumab Treatment for Retinal Vein Occlusion: BRAVO and CRUISE Trials. (24424249)
2014
2
Thrombophilia and vascular risk factors in retinal vein occlusion. (23566482)
2013
3
Progressive optic nerve collateralization after serial intravitreal ranibizumab injections for central retinal vein occlusion. (23190926)
2013
4
Vitreous attachment in age-related macular degeneration, diabetic macular edema, and retinal vein occlusion: a systematic review and metaanalysis. (23591535)
2013
5
Proteomic analysis of aqueous humor from patients with branch retinal vein occlusion-induced macular edema. (24068204)
2013
6
Reading Center Characterization of Central Retinal Vein Occlusion Using Optical Coherence Tomography During the COPERNICUS Trial. (24381819)
2013
7
Recalcitrant macular edema after intravitreal bevacizumab is responsive to an intravitreal dexamethasone implant in retinal vein occlusion. (23518900)
2013
8
Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study. (23218699)
2013
9
Subfoveal choroidal thickness in retinal vein occlusion. (24246829)
2013
10
Combined intravitreal bevacizumab and grid laser photocoagulation for macular edema secondary to branch retinal vein occlusion. (22101497)
2012
11
Benefit from bevacizumab for macular edema in central retinal vein occlusion: twelve-month results of a prospective, randomized study. (22902212)
2012
12
Vitreous inflammatory factors and serous macular detachment in branch retinal vein occlusion. (21866074)
2012
13
Triamcinolone intravitreal injection and intraocular pressure in macular edema associated with retinal vein occlusion. (23225839)
2012
14
Homocysteine induces oxidative stress in young adult central retinal vein occlusion. (22628536)
2012
15
Importance of complete haematological workup for relatives of young patients presenting central retinal vein occlusion. (21484662)
2011
16
Steroids and macular edema from retinal vein occlusion. (23264327)
2011
17
Focal macular electroretinogram in macular edema secondary to central retinal vein occlusion. (21398283)
2011
18
Vitreous levels of interleukine-8 and monocyte chemoattractant protein-1 in macular oedema with branch retinal vein occlusion. (20111061)
2010
19
Pigment epithelium-derived factor and vascular endothelial growth factor in branch retinal vein occlusion with macular edema. (20714746)
2010
20
Branch retinal artery occlusion and non-ischemic central retinal vein occlusion due to hyperhomocysteinemia in a 14-year-old child. (21158360)
2010
21
Coagulation disorders and the risk of retinal vein occlusion. (20126828)
2010
22
MTHFR C677T homozygous mutation in a patient with pigmentary glaucoma and central retinal vein occlusion. (20068371)
2010
23
Central retinal vein occlusion following infliximab treatment for plaque-type psoriasis. (20883414)
2010
24
Central retinal vein occlusion following Sirsasana (headstand posture). (19075418)
2009
25
Fenethylline as a possible etiology for retinal vein occlusion. (20214057)
2009
26
Ranibizumab for macular edema due to retinal vein occlusions: implication of VEGF as a critical stimulator. (18362932)
2008
27
Surgical treatment of central retinal vein occlusion. (18494725)
2008
28
Three-dimensional imaging of cystoid macular edema in retinal vein occlusion. (17675242)
2008
29
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
30
One-year safety and efficacy of intravitreal triamcinolone acetonide for the management of macular edema secondary to central retinal vein occlusion. (17031288)
2006
31
Lamina puncture for central retinal vein occlusion: results of a pilot trial. (16832020)
2006
32
Intravitreal triamcinolone for acute central retinal vein occlusion; a randomized clinical trial. (16738858)
2006
33
Vitrectomy with complete posterior hyaloid removal for ischemic central retinal vein occlusion: series of cases. (15943889)
2005
34
Intravitreal triamcinolone acetonide for cystoid macular edema in nonischemic central retinal vein occlusion. (15860292)
2005
35
Retinal vein occlusion, homocysteine, and methylene tetrahydrofolate reductase genotype. (16303969)
2005
36
Vitrectomy and radial optic neurotomy for central retinal vein occlusion: effects on visual acuity and macular anatomy. (15931541)
2005
37
Influence of factor V Leiden on the development of neovascularisation secondary to central retinal vein occlusion. (12598443)
2003
38
Central retinal vein occlusion risk profile: a case-control study. (12841567)
2003
39
Perivenular macular whitening during acute central retinal vein occlusion. (14557193)
2003
40
Retinochoroidal collateral veins protect against anterior segment neovascularization after central retinal vein occlusion. (12617702)
2003
41
Injection of tissue plasminogen activator into a branch retinal vein in eyes with central retinal vein occlusion. (11733266)
2001
42
Central retinal vein occlusion in a patient with thrombotic thrombocytopenic purpura. (11336953)
2001
43
Hyperhomocystinemia in patients with nonarteritic anterior ischemic optic neuropathy, central retinal artery occlusion, and central retinal vein occlusion. (10919914)
2000
44
Central retinal vein occlusion due to hyperviscosity syndrome. (10645832)
2000
45
Central retinal vein occlusion combined with cilioretinal artery occlusion. (10761407)
1999
46
Acute central retinal vein occlusion successfully treated with intravenous thrombolysis. (10636648)
1999
47
Fundus photographic, fluorescein angiographic, and indocyanine green angiographic signs in successful laser chorioretinal venous anastomosis for central retinal vein occlusion. (10599655)
1999
48
Factor V Leiden, activated protein C resistance, and retinal vein occlusion. (9730172)
1998
49
Plasma endothelin-1 concentrations in patients with retinal vein occlusions. (9713055)
1998
50
Axial length and hyperopia in eyes with retinal vein occlusions. (9700008)
1997-1998

Genetic Variations for Retinal Vein Occlusion

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Expression for genes affiliated with Retinal Vein Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vein Occlusion

Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2ITGA2, VWF
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.2VEGFA, JAK2, IL6
310.2F12, PLAT, VEGFA
410.1SERPINE1, PLAT, HRG
5
Hide members
10.1F2, HRG, VWF
610.1F2, VWF, ITGA2
7
Hide members
10.1F5, F12, F2, SERPINC1
8
Translation Insulin regulation of translation
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10.1JAK2, VEGFA, PLAT, SERPINE1
910.0SERPINE1, MTHFR, IL6, F2, PLAT
109.9JAK2, ITGA2, VEGFA, IL6, VWF
11
Hide members
9.9F8, SERPINE1, HRG, VWF, VEGFA, F5
12
Hide members
9.8F8, VEGFA, F12, F5, ITGA2, JAK2
13
Hide members
9.7F2, PLAT, SERPINE1, VWF, F12, F5
14
Hide members
9.7F2, SERPINE1, PLAT, F5, VWF, F12
15
Hide members
9.6F8, ITGA2, F5, F12, F2, SERPINE1

Compounds for genes affiliated with Retinal Vein Occlusion

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.6APOH, VWF, SERPINC1
2estrogen4410.6F12, APOH, F8
3creatinine4410.6APOH, F8, F5, F2
4aspartate4410.5F2, JAK2, G6PD, F8
5spectrozyme4410.5F5, SERPINC1, F2, PLAT
6pge14410.4F5, APOH, F2, PLAT, SERPINE1
7ancrod4410.4F5, F2, PLAT, SERPINC1, SERPINE1
8batroxobin4410.4PLAT, F2, F5, SERPINE1
9kaolin4410.4F2, APOH, F8, F5, F12
10fondaparinux4410.4PLAT, SERPINC1, F2, F5
11aprotinin44 1111.4F5, VWF, PLAT, SERPINE1, SERPINC1
12bivalirudin44 1111.4PLAT, F2, F5, SERPINC1
13Drotrecogin alfa1110.4SERPINE1, F8, F2, PROCR, F5
14matrigel4410.4SERPINE1, JAK2, ITGA2, HRG
15tirofiban44 1111.3PLAT, ITGA2, F2, SERPINC1, VWF
16ristocetin4410.3SERPINC1, F2, VWF, F8, F5, PLAT
17epsilon aminocaproic acid4410.3PLAT, HRG, F2, SERPINE1, SERPINC1
18tranexamic acid44 1111.3PLAT, SERPINC1, F2, VWF, F8, SERPINE1
19protamine4410.3F2, IL6, PLAT, F5, SERPINE1, SERPINC1
20argatroban44 1111.3F2, SERPINC1, PLAT, F5
2111-dehydrothromboxane b24410.3SERPINE1, VWF, APOH, F2
22cyclophosphamide44 49 1112.3VWF, MTHFR, F5, G6PD, F8, APOH
23dermatan sulfate4410.3F2, HRG, VWF, F5, SERPINC1, PLAT
24epinephrine44 11 2412.3JAK2, G6PD, VWF, F5, F2, F8
25phosphatidylethanolamine44 1111.2F8, F5, PROCR, F2, APOH
26clopidogrel49 44 11 2413.2ITGA2, SERPINC1, PLAT, F2, VWF
27desmopressin44 59 28 1113.2SERPINC1, SERPINE1, F2, PLAT, F5, VWF
28hydroxyethyl starch4410.2F8, VWF, F2, SERPINC1
29ppack4410.2F2, SERPINC1, PLAT, VWF
30gabexate mesilate4410.2SERPINC1, PLAT, F5, IL6
31simvastatin44 49 59 28 11 2415.2VEGFA, IL6, VWF, F5, PLAT, SERPINE1
32prostacyclin4410.1PLAT, VWF, VEGFA, F5, F8, APOH
33hirudin4410.1F8, SERPINE1, SERPINC1, PLAT, F2, VWF
34atorvastatin44 49 28 11 2414.1VWF, VEGFA, F5, SERPINE1, PLAT, IL6
35endotoxin4410.1SERPINE1, IL6, F5, JAK2, APOH, F8
36dextran sulfate4410.1APOH, IL6, F5, JAK2
37homocysteine44 2411.1F8, F5, MTHFR, VWF, PLAT, SERPINE1
38serine4410.1F12, PROCR, JAK2, F8, G6PD, HRG
39heparin44 28 11 2413.1MTHFR, F12, VEGFA, HRG, SERPINF1, ITGA2
40n acetylcysteine4410.0SERPINC1, VEGFA, G6PD, IL6, VWF, F2
41protamine sulfate4410.0F2, F5, PLAT, SERPINC1
42kininogen4410.0F2, PLAT, SERPINE1, SERPINC1, HRG, VWF
43phospholipid4410.0APOH, JAK2, ITGA2, F5, PROCR, F2
44cholesterol44 28 11 2412.9PLAT, VWF, F8, JAK2, F5, MTHFR
45ascorbic acid44 2410.8G6PD, JAK2, F5, MTHFR, VWF, PLAT
46nitric oxide44 11 2411.7PROCR, F8, ITGA2, SERPINF1, SERPINE1, VWF
47vegf449.7SERPINF1, VEGFA, F5, ITGA2, JAK2, APOH
48aspirin44 49 28 2412.6ITGA2, JAK2, G6PD, F8, APOH, MTHFR
49citrate449.6SERPINC1, F8, G6PD, VWF, F2, F5
50fibrinogen449.5APOH, F8, ITGA2, F5, MTHFR, F12

GO Terms for genes affiliated with Retinal Vein Occlusion

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16Gene Ontology
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Cellular components related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.8SERPINF1, LOXL1, APOH, VWF, SERPINE1, PLAT
2platelet alpha granule lumenGO:0310939.8SERPINE1, F8, HRG, VWF, VEGFA, F5
3extracellular spaceGO:0056159.3IL6, PLAT, SERPINE1, SERPINC1, SERPINF1, VEGFA
4extracellular regionGO:0055768.8LOXL1, SERPINC1, SERPINE1, PLAT, F2, HRG

Biological processes related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.5APOH, PLAT
2negative regulation of cell adhesion mediated by integrinGO:03362910.4HRG, SERPINE1
3acute-phase responseGO:00695310.4F8, F2, IL6
4negative regulation of angiogenesisGO:01652510.3SERPINF1, HRG, APOH
5negative regulation of fibrinolysisGO:05191810.3APOH, HRG, SERPINE1, F2
6regulation of blood coagulationGO:03019310.3HRG, F2
7positive regulation of blood coagulationGO:03019410.3F12, APOH, SERPINE1, F2
8negative regulation of blood coagulationGO:03019510.3SERPINE1, APOH
9negative regulation of endopeptidase activityGO:01095110.3SERPINE1, SERPINC1, SERPINF1
10blood coagulation, intrinsic pathwayGO:00759710.2F8, APOH, VWF, F2, F12
11fibrinolysisGO:04273010.2F12, HRG, F2, PLAT, SERPINE1
12positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2IL6, VEGFA, JAK2
13positive regulation of protein import into nucleus, translocationGO:03316010.2IL6, JAK2
14platelet degranulationGO:00257610.1SERPINE1, VWF, F8, F5, VEGFA, HRG
15platelet activationGO:03016810.0F2, IL6, VWF, HRG, VEGFA, SERPINE1
16positive regulation of focal adhesion assemblyGO:05189410.0HRG, VEGFA
17blood coagulationGO:0075969.4PROCR, VEGFA, VWF, HRG, F2, PLAT

Molecular functions related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin bindingGO:01986510.2HRG, VWF
2protease bindingGO:00202010.2VWF, SERPINE1, SERPINC1
3serine-type endopeptidase inhibitor activityGO:00486710.1HRG, SERPINE1, SERPINF1, SERPINC1
4heparin bindingGO:00820110.0APOH, VEGFA, HRG, SERPINC1
5copper ion bindingGO:0055079.9F5, F8, LOXL1
6protein bindingGO:0055159.0VWF, SERPINE1, PLAT, F2, HRG, ITGA2

Products for genes affiliated with Retinal Vein Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet