MCID: RTN022
MIFTS: 48

Retinal Vein Occlusion malady

Cardiovascular diseases, Rare diseases categories

Aliases & Classifications for Retinal Vein Occlusion

About this section

Retinal Vein Occlusion, Aliases & Descriptions:

Name: Retinal Vein Occlusion 30 9 11 43 60
Central Retinal Vein Occlusion 60
 
Occlusion, of Retinal Vein 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:1727
NCIt38 C34981
SNOMED-CT55 46085004
MeSH33 D012170

Summaries for Retinal Vein Occlusion

About this section


MalaCards based summary: Retinal Vein Occlusion, also known as central retinal vein occlusion, is related to retinal artery occlusion and central retinal vein occlusion. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Glypican 1 network. The compounds inogatran and ecarin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and bone, and related mouse phenotypes are vision/eye and cardiovascular system.

Related Diseases for Retinal Vein Occlusion

About this section

Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 172)
idRelated DiseaseScoreTop Affiliating Genes
1retinal artery occlusion31.8APOH
2central retinal vein occlusion31.7APOH, VEGFA, MTHFR, PLAT, F5
3branch retinal artery occlusion31.7F5
4macular holes31.5SERPINF1
5central retinal artery occlusion31.2PLAT
6purpura31.2SERPINC1
7retinal vascular occlusion31.1APOH, F5
8retinal detachment30.8PLAT, VEGFA, SERPINF1
9diabetic macular edema30.8SERPINF1, VEGFA
10nonarteritic anterior ischemic optic neuropathy30.7F5, MTHFR
11lupus erythematosus30.7APOH, SERPINC1, F5
12sneddon syndrome30.6APOH, SERPINC1
13protein s deficiency30.6SERPINC1, MTHFR, APOH, F5
14eclampsia30.6MTHFR, SERPINC1
15factor xii deficiency30.6F5, APOH, SERPINC1
16hyperhomocysteinemia30.4F5, PLAT, MTHFR, APOH, SERPINC1
17migraine30.3MTHFR, APOH
18blindness30.3SERPINF1, VEGFA
19rheumatoid arthritis30.3MTHFR, APOH, VEGFA
20vascular disease30.2APOH, VEGFA, SERPINC1
21thrombophilia30.2SERPINC1, PLAT, F5, MTHFR, APOH
22hellp syndrome30.1APOH, SERPINC1, MTHFR, F5
23protein c deficiency30.0MTHFR, APOH, F5, SERPINC1
24coronary artery disease30.0PLAT, SERPINC1, MTHFR
25atherosclerosis29.7MTHFR, APOH, SERPINF1, PLAT, SERPINC1
26myocardial infarction29.7PLAT, F5, SERPINC1, MTHFR
27antiphospholipid syndrome29.5APOH, F5, PLAT, MTHFR, SERPINC1
28retinitis11.7
29endotheliitis10.9
30chorioretinitis10.8
31neovascular glaucoma10.7
32choroiditis10.7
33neuropathy10.6
34ischemia10.6
35ischemic optic neuropathy10.5
36tuberculosis10.5
37vasculitis10.5
38thrombophlebitis10.5APOH
39partial of retinal vein occlusion10.5
40thrombotic thrombocytopenic purpura10.5
41vitreous detachment10.5
42retinal vasculitis10.5
43patent foramen ovale10.4F5
44systemic lupus erythematosus10.4
45hepatitis10.4
46leukemia10.4
47retinal ischemia10.4
48hepatitis c10.4
49rubeosis iridis10.4
50open-angle glaucoma10.4

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Symptoms for Retinal Vein Occlusion

About this section

Drugs & Therapeutics for Retinal Vein Occlusion

About this section

Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

About this section

Anatomical Context for Retinal Vein Occlusion

About this section

MalaCards organs/tissues related to Retinal Vein Occlusion:

31
Eye, Endothelial, Bone, Retina, Myeloid, Colon, Liver, Skin, Testes, Monocytes

Animal Models for Retinal Vein Occlusion or affiliated genes

About this section

MGI Mouse Phenotypes related to Retinal Vein Occlusion:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6PLAT, MTHFR, SERPINC1, SERPINF1, VEGFA
2MP:00053857.6PLAT, VEGFA, SERPINF1, SERPINC1, F5
3MP:00053897.4MTHFR, SERPINC1, SERPINF1, PLAT, VEGFA
4MP:00053767.3PLAT, MTHFR, SERPINC1, APOH, VEGFA, F5
5MP:00036317.2F5, PLAT, MTHFR, SERPINC1, SERPINF1, VEGFA
6MP:00107687.0MTHFR, PLAT, SERPINC1, APOH, VEGFA, F5

Publications for Retinal Vein Occlusion

About this section

Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 1006)
idTitleAuthorsYear
1
Flicker electroretinograms before and after intravitreal ranibizumab injection in eyes with central retinal vein occlusion. (25597703)
2015
2
Presentation of acute central retinal vein occlusion in scleroderma. (25892936)
2015
3
Retinochoroiditis Toxoplasmotica Initially Presenting as Branch Retinal Vein Occlusion. (25902127)
2015
4
Mean platelet volume in retinal vein occlusion. (25339469)
2014
5
Intravitreal Aflibercept for Macular Edema Following Branch Retinal Vein Occlusion: The 24-Week Results of the VIBRANT Study. (25315663)
2014
6
The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis. (24800060)
2014
7
Thrombophilia and vascular risk factors in retinal vein occlusion. (23566482)
2013
8
Bevacizumab for macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis. (23746130)
2013
9
Long term visual outcome after arteriolar constriction in patients with branch retinal vein occlusion. (23549514)
2013
10
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
11
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
12
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
13
Vitreoretinal traction in impending branch retinal vein occlusion: a pathogenetic role? (22688432)
2012
14
Combined intravitreal bevacizumab and grid laser photocoagulation for macular edema secondary to branch retinal vein occlusion. (22101497)
2012
15
Branch retinal vein occlusion. (23230220)
2012
16
Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion. (21402990)
2011
17
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
18
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
19
Retinal vein occlusion in high altitude. (22206565)
2011
20
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
21
Intravitreal triamcinolone for acute branch retinal vein occlusion: a randomized clinical trial. (22454718)
2011
22
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
23
Altered fibrin clot properties in patients with retinal vein occlusion. (21955304)
2011
24
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
25
Intravitreal injection of autologous plasmin enzyme for macular edema associated with branch retinal vein occlusion. (20801424)
2010
26
Comparison of bevacizumab and triamcinolone for treatment of macular edema secondary to branch retinal vein occlusion in a pair-matched analysis. (20424494)
2010
27
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
28
Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. (20664492)
2010
29
An asymptomatic retinal vein occlusion and retinal arterial emboli in the same eye. (20935345)
2010
30
The incidence of retinal vein occlusion in the ocular hypertension treatment study. (20031222)
2010
31
Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion. (20045570)
2010
32
Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. (18293182)
2008
33
Bilateral simultaneous central retinal vein occlusion secondary to hyperviscosity in Waldenstrom's macroglobulinaemia. (18600248)
2008
34
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
35
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
36
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
37
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
38
Recurrent branch retinal vein occlusion with factor V leiden mutation. (16113634)
2006
39
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
40
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
41
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
42
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
43
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
44
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
45
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
46
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
47
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
48
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Retinal Vein Occlusion

About this section

Expression for genes affiliated with Retinal Vein Occlusion

About this section
Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

About this section

Pathways related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VEGFA, F5
29.3VEGFA, SERPINC1
3
Show member pathways
thioredoxin pathway36
9.2PLAT, MTHFR
49.1PLAT, VEGFA
59.1VEGFA, PLAT
6
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
8.7SERPINC1, PLAT, F5
7
Show member pathways
8.7F5, PLAT, SERPINC1
8
Show member pathways
8.1VEGFA, SERPINC1, PLAT, F5

Compounds for genes affiliated with Retinal Vein Occlusion

About this section

Compounds related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1inogatran439.8SERPINC1, F5
2ecarin439.7SERPINC1, F5
3verteporfin439.7SERPINF1, VEGFA
4fondaparinux439.7PLAT, F5
5hirugen439.7F5, SERPINC1
6vitamin b12439.5APOH, MTHFR, F5
7nafamostat mesilate439.5F5, SERPINC1
8ximelagatran43 1210.5SERPINC1, F5
9uric acid43 2410.4F5, APOH, MTHFR
10dextran sulfate439.4SERPINC1, F5, APOH
11integrilin439.4SERPINC1, PLAT
12reviparin439.4PLAT, SERPINC1
13efegatran439.3SERPINC1, PLAT
14batroxobin439.2F5, PLAT
15danaparoid439.2SERPINC1, F5
16fibrinopeptide a439.1PLAT, SERPINC1
17pge1439.1APOH, PLAT, F5
18cyclophosphamide43 49 1211.1F5, MTHFR, APOH, VEGFA
19progestin439.1F5, SERPINC1, VEGFA
20eaca439.1SERPINC1, PLAT
21spectrozyme439.1PLAT, F5, SERPINC1
22ancrod439.1F5, PLAT, SERPINC1
23bivalirudin43 1210.1F5, PLAT, SERPINC1
24argatroban43 1210.1SERPINC1, PLAT, F5
25gabexate mesilate439.1SERPINC1, PLAT, F5
26protamine sulfate439.1F5, SERPINC1, PLAT
27ristocetin439.1F5, SERPINC1, PLAT
28levonorgestrel43 59 28 1212.0PLAT, SERPINC1, F5
29desmopressin43 59 28 1212.0SERPINC1, PLAT, F5
30hirudin439.0F5, SERPINC1, PLAT
31ticlopidine43 1210.0APOH, SERPINC1, PLAT
32protamine439.0F5, PLAT, SERPINC1
33folate439.0F5, APOH, SERPINC1, MTHFR
34dermatan sulfate439.0SERPINC1, PLAT, F5
35fluorescein43 129.9F5, VEGFA, SERPINF1, SERPINC1
36aprotinin43 129.9F5, PLAT, SERPINC1
37p002438.8F5, PLAT, MTHFR, APOH
38kininogen438.7APOH, SERPINC1, PLAT, F5
39ascorbic acid43 249.6SERPINC1, PLAT, MTHFR, F5
40tamoxifen43 49 28 1211.5F5, PLAT, SERPINC1, VEGFA
41estrogen438.4VEGFA, APOH, SERPINC1, MTHFR, F5
42vegf438.4VEGFA, F5, SERPINC1, SERPINF1, APOH
43glutamate438.3F5, SERPINF1, APOH, PLAT, MTHFR
44warfarin43 49 24 1211.2F5, PLAT, MTHFR, SERPINC1, APOH
45homocysteine43 249.2SERPINC1, APOH, PLAT, F5, MTHFR
46aspirin43 49 28 2411.2MTHFR, PLAT, F5, SERPINC1, APOH
47fibrinogen438.2F5, PLAT, APOH, MTHFR, SERPINC1
48creatinine438.2APOH, SERPINC1, MTHFR, F5, PLAT
49prostacyclin438.2SERPINC1, F5, PLAT, APOH, VEGFA
50heparin43 28 24 1210.2F5, PLAT, MTHFR, SERPINC1, SERPINF1, APOH

GO Terms for genes affiliated with Retinal Vein Occlusion

About this section

Cellular components related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:00310939.3F5, VEGFA
2secretory granuleGO:00301419.1VEGFA, PLAT
3extracellular matrixGO:00310128.7PLAT, APOH, SERPINF1
4cell surfaceGO:00099868.6VEGFA, PLAT, APOH
5extracellular regionGO:00055767.7F5, VEGFA, SERPINF1, SERPINC1, PLAT
6extracellular spaceGO:00056157.3VEGFA, APOH, SERPINF1, SERPINC1, F5, PLAT

Biological processes related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:00080159.8MTHFR, F5
2negative regulation of angiogenesisGO:00165259.7SERPINF1, APOH
3regulation of proteolysisGO:00301629.5SERPINF1, SERPINC1
4plasminogen activationGO:00316399.5PLAT, APOH
5platelet degranulationGO:00025769.5F5, VEGFA
6negative regulation of inflammatory responseGO:00507289.4SERPINC1, SERPINF1
7negative regulation of endopeptidase activityGO:00109519.3SERPINC1, SERPINF1
8kidney developmentGO:00018229.1SERPINF1, VEGFA
9response to glucocorticoidGO:00513849.1SERPINF1, PLAT
10response to hypoxiaGO:00016668.9PLAT, MTHFR, VEGFA
11blood coagulationGO:00075968.4VEGFA, SERPINC1, PLAT, F5

Molecular functions related to Retinal Vein Occlusion according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00048679.3SERPINC1, SERPINF1
2heparin bindingGO:00082018.6SERPINC1, APOH, VEGFA

Products for genes affiliated with Retinal Vein Occlusion

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Retinal Vein Occlusion

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet