MCID: RTN022
MIFTS: 56

Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Retinal Vein Occlusion

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66Wikipedia, 34MalaCards
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Wikipedia:66 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to central retinal vein occlusion and retinal artery occlusion. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Glypican 1 network. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Retinal Vein Occlusion

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9Disease Ontology, 11DISEASES, 46Novoseek, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

retinal vein occlusion 9 11 46 32 63
occlusion, of retinal vein 9


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Disease Ontology9 DOID:1727
MeSH36 D012170
SNOMED-CT59 46085004
NCIt41 C34981

Related Diseases for Retinal Vein Occlusion

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18GeneCards, 19GeneDecks
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Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal vein occlusion32.1APOH, VEGFA, MTHFR, PLAT, F5
2retinal artery occlusion31.2APOH
3macular holes31.0SERPINF1
4branch retinal artery occlusion31.0F5
5retinal detachment31.0PLAT, VEGFA, SERPINF1
6hypertension31.0F5, PLAT, MTHFR
7hyperhomocysteinemia30.9F5, PLAT, MTHFR, APOH, SERPINC1
8central retinal artery occlusion30.8PLAT
9thrombophilia30.7SERPINC1, PLAT, F5, MTHFR, APOH
10protein s deficiency30.7SERPINC1, F5
11retinal vascular occlusion30.7APOH, F5
12purpura30.7SERPINC1
13diabetic retinopathy30.6SERPINF1, VEGFA
14lupus erythematosus30.6APOH, SERPINC1, F5
15diabetic macular edema30.5SERPINF1, VEGFA
16factor xii deficiency30.5F5, APOH, SERPINC1
17antithrombin iii deficiency30.4MTHFR, F5, SERPINC1, APOH
18rheumatoid arthritis30.4MTHFR, APOH, VEGFA
19atherosclerosis30.4MTHFR, APOH, SERPINF1, PLAT, SERPINC1
20sneddon syndrome30.3APOH, SERPINC1
21eclampsia30.3MTHFR, SERPINC1
22venous thrombosis30.3SERPINC1, MTHFR, PLAT, APOH, F5
23migraine30.3MTHFR, APOH
24blindness30.3SERPINF1, VEGFA
25age related macular degeneration30.2VEGFA, PLAT
26vascular disease30.2APOH, VEGFA, SERPINC1
27hellp syndrome30.2APOH, SERPINC1, MTHFR, F5
28protein c deficiency30.2MTHFR, APOH, F5, SERPINC1
29coronary artery disease30.2PLAT, SERPINC1, MTHFR
30myocardial infarction30.1PLAT, F5, SERPINC1, MTHFR
31antiphospholipid syndrome30.1APOH, F5, PLAT, MTHFR, SERPINC1
32pre-eclampsia30.0VEGFA, SERPINC1, PLAT, APOH, MTHFR, F5
33retinitis11.6
34endotheliitis10.9
35cystoid macular edema10.8
36glaucoma10.8
37chorioretinitis10.7
38neovascular glaucoma10.7
39choroiditis10.6
40neuropathy10.6
41tuberculosis10.5
42vitreous detachment10.5
43ischemia10.5
44vasculitis10.5
45hepatitis c10.4
46partial of retinal vein occlusion10.4
47thrombotic thrombocytopenic purpura10.4
48retinal vasculitis10.4
49retinal ischemia10.4
50systemic lupus erythematosus10.4

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Symptoms for Retinal Vein Occlusion

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Drugs & Therapeutics for Retinal Vein Occlusion

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Search CenterWatch for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

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Anatomical Context for Retinal Vein Occlusion

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34MalaCards
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MalaCards organs/tissues related to Retinal Vein Occlusion:

34
Retina, Eye, Endothelial, Bone, Myeloid, Colon, Liver, Testes, Monocytes, Skin

Animal Models for Retinal Vein Occlusion or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Retinal Vein Occlusion:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6PLAT, MTHFR, SERPINC1, SERPINF1, VEGFA
2MP:00053857.6F5, PLAT, SERPINC1, SERPINF1, VEGFA
3MP:00053897.4VEGFA, SERPINF1, SERPINC1, MTHFR, PLAT
4MP:00053767.3VEGFA, APOH, SERPINC1, MTHFR, PLAT, F5
5MP:00036317.2VEGFA, SERPINF1, SERPINC1, MTHFR, PLAT, F5
6MP:00107687.0VEGFA, APOH, SERPINC1, MTHFR, PLAT, F5

Publications for Retinal Vein Occlusion

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53PubMed
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Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 929)
idTitleAuthorsYear
1
Thrombophilia and vascular risk factors in retinal vein occlusion. (23566482)
2013
2
Bevacizumab for macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis. (23746130)
2013
3
Long term visual outcome after arteriolar constriction in patients with branch retinal vein occlusion. (23549514)
2013
4
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
5
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
6
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
7
Vitreoretinal traction in impending branch retinal vein occlusion: a pathogenetic role? (22688432)
2012
8
Combined intravitreal bevacizumab and grid laser photocoagulation for macular edema secondary to branch retinal vein occlusion. (22101497)
2012
9
Branch retinal vein occlusion. (23230220)
2012
10
Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion. (21402990)
2011
11
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
12
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
13
Retinal vein occlusion in high altitude. (22206565)
2011
14
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
15
Intravitreal triamcinolone for acute branch retinal vein occlusion: a randomized clinical trial. (22454718)
2011
16
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
17
Altered fibrin clot properties in patients with retinal vein occlusion. (21955304)
2011
18
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
19
Intravitreal injection of autologous plasmin enzyme for macular edema associated with branch retinal vein occlusion. (20801424)
2010
20
Comparison of bevacizumab and triamcinolone for treatment of macular edema secondary to branch retinal vein occlusion in a pair-matched analysis. (20424494)
2010
21
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
22
Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. (20664492)
2010
23
An asymptomatic retinal vein occlusion and retinal arterial emboli in the same eye. (20935345)
2010
24
The incidence of retinal vein occlusion in the ocular hypertension treatment study. (20031222)
2010
25
Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion. (20045570)
2010
26
Citalopram-associated central retinal vein occlusion. (18545940)
2009
27
Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. (18293182)
2008
28
Bilateral simultaneous central retinal vein occlusion secondary to hyperviscosity in Waldenstrom's macroglobulinaemia. (18600248)
2008
29
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
30
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. (18759522)
2008
31
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
32
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
33
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
34
Recurrent branch retinal vein occlusion with factor V leiden mutation. (16113634)
2006
35
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
36
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
37
Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. (15968383)
2005
38
Central retinal vein occlusion secondary to an intraocular nematode. (15883297)
2005
39
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
40
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
41
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
42
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
43
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
44
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
45
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
46
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
47
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
48
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Retinal Vein Occlusion

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Expression for genes affiliated with Retinal Vein Occlusion

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vein Occlusion

Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

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Sources:
51PathCards, 56Reactome, 39NCBI BioSystems Database, 61Thomson Reuters, 31KEGG, 54QIAGEN, 55R&D Systems
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Pathways related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6VEGFA, F5
29.3VEGFA, SERPINC1
3
Show member pathways
thioredoxin pathway39
9.2PLAT, MTHFR
49.1PLAT, VEGFA
59.1VEGFA, PLAT
6
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
8.7SERPINC1, PLAT, F5
7
Show member pathways
8.7F5, PLAT, SERPINC1
8
Show member pathways
8.1VEGFA, SERPINC1, PLAT, F5

Compounds for genes affiliated with Retinal Vein Occlusion

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Sources:
46Novoseek, 25HMDB, 52PharmGKB, 12DrugBank, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1inogatran469.8F5, SERPINC1
2hirugen469.7SERPINC1, F5
3verteporfin469.7SERPINF1, VEGFA
4fondaparinux469.7PLAT, F5
5ecarin469.7F5, SERPINC1
6nafamostat mesilate469.5F5, SERPINC1
7vitamin b12469.5F5, MTHFR, APOH
8uric acid46 2510.4MTHFR, APOH, F5
9dextran sulfate469.4SERPINC1, F5, APOH
10danaparoid469.4SERPINC1, F5
11integrilin469.4SERPINC1, PLAT
12reviparin469.4PLAT, SERPINC1
13efegatran469.3PLAT, SERPINC1
14batroxobin469.3F5, PLAT
15eaca469.1SERPINC1, PLAT
16pge1469.1PLAT, APOH, F5
17cyclophosphamide46 52 1211.1F5, MTHFR, APOH, VEGFA
18progestin469.1F5, SERPINC1, VEGFA
19spectrozyme469.1PLAT, F5, SERPINC1
20ancrod469.1F5, PLAT, SERPINC1
21bivalirudin46 1210.1F5, PLAT, SERPINC1
22argatroban46 1210.1SERPINC1, PLAT, F5
23gabexate mesilate469.1SERPINC1, PLAT, F5
24protamine sulfate469.1F5, SERPINC1, PLAT
25ristocetin469.1F5, SERPINC1, PLAT
26levonorgestrel46 62 30 1212.0PLAT, SERPINC1, F5
27desmopressin46 62 30 1212.0SERPINC1, PLAT, F5
28p-amino benzamidine469.0SERPINC1, PLAT
29hirudin469.0F5, SERPINC1, PLAT
30ticlopidine46 1210.0APOH, SERPINC1, PLAT
31protamine469.0F5, PLAT, SERPINC1
32folate469.0F5, APOH, SERPINC1, MTHFR
33dermatan sulfate469.0SERPINC1, PLAT, F5
34fluorescein46 129.9F5, VEGFA, SERPINF1, SERPINC1
35aprotinin46 129.9SERPINC1, PLAT, F5
36p002468.8F5, PLAT, MTHFR, APOH
37fibrinopeptide a468.7PLAT, SERPINC1
38kininogen468.7APOH, SERPINC1, PLAT, F5
39ascorbic acid46 259.6SERPINC1, PLAT, MTHFR, F5
40tamoxifen46 52 30 1211.5F5, PLAT, SERPINC1, VEGFA
41estrogen468.4VEGFA, SERPINC1, APOH, MTHFR, F5
42vegf468.4VEGFA, F5, SERPINC1, SERPINF1, APOH
43glutamate468.3F5, SERPINF1, APOH, PLAT, MTHFR
44warfarin46 52 25 1211.2F5, PLAT, MTHFR, SERPINC1, APOH
45homocysteine46 259.2SERPINC1, APOH, PLAT, F5, MTHFR
46aspirin46 52 30 2511.2MTHFR, PLAT, F5, SERPINC1, APOH
47fibrinogen468.2F5, PLAT, APOH, MTHFR, SERPINC1
48creatinine468.2APOH, SERPINC1, MTHFR, F5, PLAT
49prostacyclin468.2SERPINC1, F5, PLAT, APOH, VEGFA
50heparin46 30 25 1210.2F5, PLAT, MTHFR, SERPINC1, SERPINF1, APOH

GO Terms for genes affiliated with Retinal Vein Occlusion

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17Gene Ontology
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Cellular components related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, VEGFA
2secretory granuleGO:0301419.1VEGFA, PLAT
3extracellular matrixGO:0310128.7PLAT, APOH, SERPINF1
4cell surfaceGO:0099868.6VEGFA, PLAT, APOH
5extracellular regionGO:0055767.7F5, VEGFA, SERPINF1, SERPINC1, PLAT
6extracellular spaceGO:0056157.3VEGFA, APOH, SERPINF1, SERPINC1, F5, PLAT

Biological processes related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.8MTHFR, F5
2negative regulation of angiogenesisGO:0165259.7SERPINF1, APOH
3regulation of proteolysisGO:0301629.5SERPINF1, SERPINC1
4plasminogen activationGO:0316399.5PLAT, APOH
5platelet degranulationGO:0025769.5F5, VEGFA
6negative regulation of inflammatory responseGO:0507289.4SERPINC1, SERPINF1
7negative regulation of endopeptidase activityGO:0109519.3SERPINC1, SERPINF1
8kidney developmentGO:0018229.1SERPINF1, VEGFA
9response to glucocorticoidGO:0513849.1SERPINF1, PLAT
10response to hypoxiaGO:0016668.9PLAT, MTHFR, VEGFA
11blood coagulationGO:0075968.4VEGFA, SERPINC1, PLAT, F5

Molecular functions related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.3SERPINC1, SERPINF1
2heparin bindingGO:0082018.6SERPINC1, APOH, VEGFA

Products for genes affiliated with Retinal Vein Occlusion

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  • Antibodies
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Sources for Retinal Vein Occlusion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet