MCID: RTN022
MIFTS: 53

Retinal Vein Occlusion malady

Summaries for Retinal Vein Occlusion

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to central retinal vein occlusion and central retinal artery occlusion. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Platelet Adhesion to exposed collagen and Immune response Oncostatin M signaling via JAK-Stat in human cells. The compounds warfarin and estrogen have been mentioned in the context of this disorder. Related mouse phenotypes are cardiovascular system and integument.

Aliases & Classifications for Retinal Vein Occlusion

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

retinal vein occlusion 8 10 45 31 61
occlusion, of retinal vein 8


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Disease Ontology8 DOID:1727
MeSH35 D012170
SNOMED-CT57 46085004
NCIt40 C34981

Related Diseases for Retinal Vein Occlusion

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Retinal Vein Occlusion family:

central retinal vein occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal vein occlusion32.2PLAT, VEGFA, MTHFR, F5, APOH
2central retinal artery occlusion31.2PLAT
3hyperhomocysteinemia31.0SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
4branch retinal artery occlusion30.9F5
5thrombophilia30.9SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
6factor v deficiency30.7F2, F5, F8
7protein c deficiency30.7SERPINC1, SERPINE1, F2, HRG, PROCR, MTHFR
8vasculitis30.6F2, VWF, APOH
9hepatitis a30.6F2, F8
10hepatitis c30.6F2, F8
11diabetic macular edema30.6SERPINF1, VEGFA
12systemic lupus erythematosus30.5F2, VWF, IL6, PROCR, F8, APOH
13atherosclerosis30.5SERPINF1, SERPINC1, SERPINE1, PLAT, VWF, IL6
14hemolytic-uremic syndrome30.4VWF
15arthritis30.4IL6
16hepatitis b30.4F2, F8
17deficiency anemia30.4F2, VWF, IL6, JAK2, G6PD
18venous thrombosis30.4SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
19eclampsia30.2SERPINC1, MTHFR
20cystic fibrosis30.2F8
21sneddon syndrome30.2SERPINC1, APOH
22sickle cell disease30.2VWF, G6PD
23polycythemia vera30.2JAK2, G6PD
24hemoglobinuria30.2G6PD
25blindness30.2SERPINF1, VEGFA
26macular holes30.2SERPINF1
27nephritis30.2APOH
28acute leukemia30.2MTHFR, JAK2
29stroke, ischemic30.2F2, F5
30uveitis30.2SERPINF1
31thrombotic thrombocytopenic purpura, acquired30.2SERPINE1, VWF, F8, APOH
32thrombocytosis30.2SERPINC1, F2, VWF, IL6, JAK2
33hellp syndrome30.2SERPINC1, SERPINE1, VWF, MTHFR, F5, APOH
34protein s deficiency30.2SERPINC1, SERPINE1, F2, MTHFR, F5, F8
35coronary artery disease,30.2SERPINE1, PLAT, VWF, IL6, MTHFR, ITGA2
36antiphospholipid syndrome30.2SERPINC1, PLAT, F2, VWF, PROCR, MTHFR
37vascular disease30.2SERPINC1, SERPINE1, PLAT, VWF, VEGFA, MTHFR
38cystoid macular edema10.8
39vein disease10.7
40neovascular glaucoma10.6
41vitreous detachment10.5
42ischemic neuropathy10.5
43ischemic optic neuropathy10.5
44tuberculosis10.5
45protein r deficiency10.5
46retinal ischemia10.5
47thrombotic thrombocytopenic purpura10.5
48retinal vasculitis10.5
49partial of retinal vein occlusion10.4
50primary open angle glaucoma10.4

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Clinical Features for Retinal Vein Occlusion

Drugs & Therapeutics for Retinal Vein Occlusion

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Search CenterWatch for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

Anatomical Context for Retinal Vein Occlusion

Animal Models for Retinal Vein Occlusion or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Retinal Vein Occlusion

Sources:
51PubMed
See all sources

Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 954)
idTitleAuthorsYear
1
Influence of pars plana vitrectomy on macular sensitivity and morphology in patients with branch retinal vein occlusion and serous retinal detachment. (23510041)
2013
2
Aqueous flare and inflammatory factors in macular edema with central retinal vein occlusion: a case series. (24325604)
2013
3
SECTORAL RETINAL NERVE FIBER LAYER THINNING IN BRANCH RETINAL VEIN OCCLUSION. (23958844)
2013
4
Platelet indices in retinal vein occlusion in hypertensive patients. (24343602)
2013
5
Vascular changes in eyes treated with dexamethasone intravitreal implant for macular edema after retinal vein occlusion. (23499064)
2013
6
Branch retinal vein occlusion and optic nerve head topographic parameters: the Singapore Indian eye study. (23435192)
2013
7
Vascular remodeling in central retinal vein occlusion following laser-induced chorioretinal anastomosis. (23494049)
2013
8
Central retinal vein occlusion as an uncommon complication of sarcoidosis. (23712809)
2013
9
Extrafoveal changes following intravitreal bevacizumab injections for macular edema secondary to branch retinal vein occlusion: an mfERG and OCT study. (23255086)
2013
10
Subfoveal serous retinal detachment associated with extramacular branch retinal vein occlusion. (23390359)
2013
11
Branch retinal vein occlusion: epidemiology, pathogenesis, risk factors, clinical features, diagnosis, and complications. An update of the literature. (23609064)
2013
12
Branch retinal vein occlusion and vitreovascular traction: a preliminary spectral domain OCT case-control study. (24022673)
2013
13
Coronary artery disease, cerebral non-fatal ischemic stroke in retinal vein occlusion: an 8-yr follow-up. (20674314)
2012
14
Disrupted foveal photoreceptors after combined cystoid spaces and retinal detachment in branch vein occlusion treated with bevacizumab. (22481482)
2012
15
Macular sensitivity and morphology after intravitreal injection of triamcinolone acetonide for macular edema with branch retinal vein occlusion. (22653545)
2012
16
Intravitreal triamcinolone for acute branch retinal vein occlusion: a randomized clinical trial. (22454718)
2011
17
Role of inflammation-related gene polymorphisms in patients with central retinal vein occlusion. (21269700)
2011
18
Intravitreal bevacizumab for treatment of serous macular detachment in central retinal vein occlusion. (21053008)
2011
19
Medical image. Retinal macroaneurysm following a branch retinal vein occlusion. (22016171)
2011
20
Lamellar macular hole formation in chronic cystoid macular edema associated with retinal vein occlusion. (21744123)
2011
21
Sequential central retinal artery occlusion and retinal vein stasis as a result of ocular ischemic syndrome. (20408094)
2010
22
Visual improvement in established central retinal vein occlusion with long-standing macular edema following systemic eculizumab treatment. (20935688)
2010
23
Antithrombotic and fibrinolytic drugs for retinal vein occlusion: a systematic review and a call for action. (20126837)
2010
24
Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion. (20417567)
2010
25
The Central Retinal Vein Bypass Study: a trial of laser-induced chorioretinal venous anastomosis for central retinal vein occlusion. (20163872)
2010
26
Comparison of surgical treatments for central retinal vein occlusion; RON vs. cannulation of tissue plasminogen activator into the retinal vein. (19734765)
2009
27
Changes in foveal thickness after vitrectomy for macular edema with branch retinal vein occlusion and intravitreal vascular endothelial growth factor. (18797821)
2009
28
The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors. Case-control study and meta-analysis. (18449423)
2008
29
Central retinal vein occlusion in hypertensive patients with chronic hepatitis C treated with interferon alpha and ribavirin. (19089580)
2008
30
Induction of retinochoroidal venous anastomosis in central retinal vein occlusion with macular edema via a full-thickness retinochoroidal incision. (18327142)
2008
31
Visual prognosis and vitreous cytokine levels after arteriovenous sheathotomy in branch retinal vein occlusion associated with macular oedema. (18039346)
2008
32
Central retinal vein occlusion heralding the relapse of haematodermic neoplasm. (18637803)
2008
33
Central retinal vein occlusion with non-arteritic ischemic optic neuropathy and cystoid macular edema. (18491126)
2008
34
Hyperhomocysteinemia and central retinal vein occlusion in Iranian population. (17636432)
2008
35
Histopathological findings after retinal endovascular lysis in central retinal vein occlusion. (17372342)
2007
36
Radial optic neurotomy in central retinal vein occlusion: comparison of outcome in younger vs older patients. (17113557)
2007
37
Protein S deficiency with homozygous factor V Leiden mutation in central retinal vein occlusion. (17641719)
2007
38
Chronic angle-closure glaucoma secondary to a suprachoroidal effusion induced by central retinal vein occlusion. (17552395)
2007
39
Modified laser-induced chorioretinal anastomosis for treatment of longstanding perfused central retinal vein occlusion. (16963859)
2006
40
Iron deficiency anemia with marked thrombocytosis complicated by central retinal vein occlusion. (16293924)
2005
41
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
42
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
43
Does radial optic neurotomy induce surgical optociliary vessels in central retinal vein occlusion? (15076970)
2004
44
The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion. (12928694)
2003
45
Central retinal vein occlusion immediately following cardiac surgery. (12757097)
2003
46
Hypercoagulable states and central retinal vein occlusion. (12904708)
2003
47
Optociliary venous anastomosis after radial optic neurotomy for central retinal vein occlusion. (12875463)
2003
48
Peripheral retinochoroidal anastomosis after central retinal vein occlusion. (12446390)
2002
49
Oral contraceptives and central retinal vein occlusion. (12568236)
2002
50
Experimental retinal vascular occlusion. II. A clinico-pathologic correlative study of simultaneous occlusion of central retinal vein and artery. (3721721)
1986

Genetic Variations for Retinal Vein Occlusion

Expression for genes affiliated with Retinal Vein Occlusion

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Retinal Vein Occlusion

Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

Sources:
54Reactome, 12EMD Millipore, 50PharmGKB, 52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2VWF, ITGA2
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
Hide members
10.2JAK2, VEGFA, IL6
310.2F12, VEGFA, PLAT
410.1HRG, PLAT, SERPINE1
5
Hide members
10.1VWF, HRG, F2
610.1ITGA2, VWF, F2
7
Hide members
10.1SERPINC1, F2, F12, F5
8
Translation Insulin regulation of translation
Hide members
10.1SERPINE1, PLAT, VEGFA, JAK2
910.0SERPINE1, PLAT, F2, IL6, MTHFR
109.9VWF, IL6, VEGFA, ITGA2, JAK2
11
Hide members
9.9F8, F5, VEGFA, VWF, HRG, SERPINE1
12
Hide members
9.8VEGFA, F12, F5, ITGA2, JAK2, F8
13
Hide members
9.7F8, F5, F12, VWF, F2, PLAT
14
Hide members
9.7SERPINC1, F8, F5, F12, VWF, F2
15
Hide members
9.6LOXL1, F8, ITGA2, F5, F12, F2

Compounds for genes affiliated with Retinal Vein Occlusion

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1warfarin45 50 11 2413.6APOH, VWF, SERPINC1
2estrogen4510.6F12, APOH, F8
3creatinine4510.6APOH, F8, F5, F2
4aspartate4510.5F2, JAK2, G6PD, F8
5spectrozyme4510.5F5, SERPINC1, F2, PLAT
6pge14510.4F5, APOH, F2, PLAT, SERPINE1
7ancrod4510.4F5, F2, PLAT, SERPINC1, SERPINE1
8batroxobin4510.4PLAT, F2, F5, SERPINE1
9kaolin4510.4F2, APOH, F8, F5, F12
10fondaparinux4510.4PLAT, SERPINC1, F2, F5
11aprotinin45 1111.4F5, VWF, PLAT, SERPINE1, SERPINC1
12bivalirudin45 1111.4PLAT, F2, F5, SERPINC1
13Drotrecogin alfa1110.4SERPINE1, F8, F2, PROCR, F5
14matrigel4510.4SERPINE1, JAK2, ITGA2, HRG
15tirofiban45 1111.3PLAT, ITGA2, F2, SERPINC1, VWF
16ristocetin4510.3SERPINC1, F2, VWF, F8, F5, PLAT
17epsilon aminocaproic acid4510.3PLAT, HRG, F2, SERPINE1, SERPINC1
18tranexamic acid45 1111.3PLAT, SERPINC1, F2, VWF, F8, SERPINE1
19protamine4510.3F2, IL6, PLAT, F5, SERPINE1, SERPINC1
20argatroban45 1111.3F2, SERPINC1, PLAT, F5
2111-dehydrothromboxane b24510.3SERPINE1, VWF, APOH, F2
22cyclophosphamide45 50 1112.3VWF, MTHFR, F5, G6PD, F8, APOH
23dermatan sulfate4510.3F2, HRG, VWF, F5, SERPINC1, PLAT
24epinephrine45 11 2412.3JAK2, G6PD, VWF, F5, F2, F8
25phosphatidylethanolamine45 1111.2F8, F5, PROCR, F2, APOH
26clopidogrel50 45 11 2413.2ITGA2, SERPINC1, PLAT, F2, VWF
27desmopressin45 60 29 1113.2SERPINC1, SERPINE1, F2, PLAT, F5, VWF
28hydroxyethyl starch4510.2F8, VWF, F2, SERPINC1
29ppack4510.2F2, SERPINC1, PLAT, VWF
30gabexate mesilate4510.2SERPINC1, PLAT, F5, IL6
31simvastatin45 50 60 29 11 2415.2VEGFA, IL6, VWF, F5, PLAT, SERPINE1
32prostacyclin4510.1PLAT, VWF, VEGFA, F5, F8, APOH
33hirudin4510.1F8, SERPINE1, SERPINC1, PLAT, F2, VWF
34atorvastatin45 50 29 11 2414.1VWF, VEGFA, F5, SERPINE1, PLAT, IL6
35endotoxin4510.1SERPINE1, IL6, F5, JAK2, APOH, F8
36dextran sulfate4510.1APOH, IL6, F5, JAK2
37homocysteine45 2411.1F8, F5, MTHFR, VWF, PLAT, SERPINE1
38serine4510.1F12, PROCR, JAK2, F8, G6PD, HRG
39heparin45 29 11 2413.1MTHFR, F12, VEGFA, HRG, SERPINF1, ITGA2
40n acetylcysteine4510.0SERPINC1, VEGFA, G6PD, IL6, VWF, F2
41protamine sulfate4510.0F2, F5, PLAT, SERPINC1
42kininogen4510.0F2, PLAT, SERPINE1, SERPINC1, HRG, VWF
43phospholipid4510.0APOH, JAK2, ITGA2, F5, PROCR, F2
44cholesterol45 29 11 2412.9PLAT, VWF, F8, JAK2, F5, MTHFR
45ascorbic acid45 2410.8G6PD, JAK2, F5, MTHFR, VWF, PLAT
46nitric oxide45 11 2411.7PROCR, F8, ITGA2, SERPINF1, SERPINE1, VWF
47vegf459.7SERPINF1, VEGFA, F5, ITGA2, JAK2, APOH
48aspirin45 50 29 2412.6ITGA2, JAK2, G6PD, F8, APOH, MTHFR
49citrate459.6SERPINC1, F8, G6PD, VWF, F2, F5
50fibrinogen459.5APOH, F8, ITGA2, F5, MTHFR, F12

GO Terms for genes affiliated with Retinal Vein Occlusion

Sources:
16Gene Ontology
See all sources

Cellular components related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.8APOH, VWF, PLAT, SERPINE1, SERPINF1, LOXL1
2platelet alpha granule lumenGO:0310939.8F8, F5, VEGFA, VWF, HRG, SERPINE1
3extracellular spaceGO:0056159.3SERPINF1, LOXL1, APOH, F8, F5, F12
4extracellular regionGO:0055768.8LOXL1, F8, F5, F12, VEGFA, IL6

Biological processes related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.5PLAT, APOH
2negative regulation of cell adhesion mediated by integrinGO:03362910.4SERPINE1, HRG
3acute-phase responseGO:00695310.4F2, IL6, F8
4negative regulation of angiogenesisGO:01652510.3APOH, HRG, SERPINF1
5negative regulation of fibrinolysisGO:05191810.3SERPINE1, F2, HRG, APOH
6regulation of blood coagulationGO:03019310.3F2, HRG
7positive regulation of blood coagulationGO:03019410.3APOH, F12, F2, SERPINE1
8negative regulation of endopeptidase activityGO:01095110.3SERPINF1, SERPINC1, SERPINE1
9positive regulation of focal adhesion assemblyGO:05189410.3HRG, VEGFA
10blood coagulation, intrinsic pathwayGO:00759710.2APOH, F8, F12, VWF, F2
11fibrinolysisGO:04273010.2F12, HRG, F2, PLAT, SERPINE1
12positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2JAK2, VEGFA, IL6
13positive regulation of protein import into nucleus, translocationGO:03316010.2IL6, JAK2
14platelet degranulationGO:00257610.1F8, F5, VEGFA, VWF, HRG, SERPINE1
15negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH
16platelet activationGO:03016810.0F8, F5, VEGFA, IL6, VWF, HRG
17blood coagulationGO:0075969.4SERPINC1, F8, JAK2, ITGA2, F5, F12

Molecular functions related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin bindingGO:01986510.2HRG, VWF
2protease bindingGO:00202010.2SERPINC1, SERPINE1, VWF
3serine-type endopeptidase inhibitor activityGO:00486710.1HRG, SERPINE1, SERPINC1, SERPINF1
4heparin bindingGO:00820110.0APOH, VEGFA, HRG, SERPINC1
5copper ion bindingGO:0055079.9F5, F8, LOXL1
6protein bindingGO:0055159.0SERPINC1, APOH, F8, G6PD, JAK2, ITGA2

Products for genes affiliated with Retinal Vein Occlusion

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vein Occlusion

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet