MCID: RTN022
MIFTS: 59

Retinal Vein Occlusion malady

Cardiovascular diseases category

Summaries for Retinal Vein Occlusion

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63Wikipedia, 32MalaCards
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Wikipedia:63 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards: Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to central retinal vein occlusion and macular retinal edema. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Platelet Adhesion to exposed collagen and Immune response Oncostatin M signaling via JAK-Stat in human cells. The compounds warfarin and estrogen have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are cardiovascular system and integument.

Aliases & Classifications for Retinal Vein Occlusion

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8Disease Ontology, 10DISEASES, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

retinal vein occlusion 8 10 44 30 60
occlusion, of retinal vein 8


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Disease Ontology8 DOID:1727
MeSH34 D012170
SNOMED-CT56 46085004
NCIt39 C34981

Related Diseases for Retinal Vein Occlusion

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17GeneCards, 18GeneDecks
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Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1central retinal vein occlusion32.2PLAT, VEGFA, MTHFR, F5, APOH
2macular retinal edema31.9SERPINF1, VEGFA
3retinal vascular occlusion31.4F5, APOH
4retinal artery occlusion31.3APOH
5central retinal artery occlusion31.2PLAT
6retinal detachment31.2SERPINF1, PLAT, VEGFA
7glaucoma31.1SERPINF1, LOXL1
8hyperhomocysteinemia31.0SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
9branch retinal artery occlusion30.9F5
10hypertension30.9SERPINE1, PLAT, F2, MTHFR, F5
11retinal disease30.9SERPINF1, SERPINE1, VWF, VEGFA, ITGA2, F8
12thrombophilia30.8SERPINC1, SERPINE1, PLAT, F2, HRG, VWF
13macular holes30.8SERPINF1
14protein s deficiency30.7SERPINC1, SERPINE1, F2, MTHFR, F5, F8
15purpura30.6SERPINC1
16ischemia30.6PLAT, VEGFA, JAK2
17vasculitis30.6F2, VWF, APOH
18hepatitis30.5F2, F8
19hepatitis c30.5F2, F8
20factor v deficiency30.5F2, F5, F8
21diabetic macular edema30.5SERPINF1, VEGFA
22antithrombin iii deficiency30.5SERPINC1, F2, MTHFR, F5, APOH
23diabetic retinopathy30.5SERPINF1, SERPINE1, VEGFA, ITGA2
24lupus erythematosus30.5SERPINC1, F2, PROCR, F5, APOH
25leukemia30.5SERPINF1, IL6, MTHFR, JAK2, F8
26systemic lupus erythematosus30.5F2, VWF, IL6, PROCR, F8, APOH
27protein c deficiency30.5SERPINC1, SERPINE1, F2, HRG, PROCR, MTHFR
28atherosclerosis30.5SERPINF1, SERPINC1, SERPINE1, PLAT, VWF, IL6
29hemolytic-uremic syndrome30.4VWF
30multiple myeloma30.4IL6
31arthritis30.4IL6
32psoriasis30.4IL6
33factor xii deficiency30.4F5
34myeloma30.4IL6, VEGFA, ITGA2, JAK2
35deficiency anemia30.4F2, VWF, IL6, JAK2, G6PD
36rheumatoid arthritis30.4HRG, IL6, VEGFA, MTHFR, ITGA2, JAK2
37pneumonia30.2IL6
38multiple sclerosis30.2IL6
39eclampsia30.2SERPINC1, MTHFR
40migraine30.2MTHFR, APOH
41cystic fibrosis30.2F8
42age related macular degeneration30.2PLAT, VEGFA
43sneddon syndrome30.2SERPINC1, APOH
44polycythemia30.2JAK2, G6PD
45sickle cell disease30.2VWF, G6PD
46polycythemia vera30.2JAK2, G6PD
47hemoglobinuria30.2G6PD
48hepatitis a30.2F2, F8
49acute leukemia30.2MTHFR, JAK2
50essential hypertension30.2SERPINE1, PLAT, VWF

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Clinical Features for Retinal Vein Occlusion

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Drugs & Therapeutics for Retinal Vein Occlusion

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Retinal Vein Occlusion

Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Search CenterWatch for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

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Anatomical Context for Retinal Vein Occlusion

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32MalaCards
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MalaCards organs/tissues related to Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Bone, Myeloid, Colon, Liver, Testes, Monocytes, Skin

Animal Models for Retinal Vein Occlusion or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinal Vein Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538510.2G6PD, F2, SERPINF1
2MP:001077110.0LOXL1, ITGA2, VEGFA, IL6, F2
3MP:00053819.6LOXL1, VEGFA, IL6, VWF, F2, PLAT
4MP:00053899.6LOXL1, F8, MTHFR, VEGFA, SERPINC1, SERPINF1
5MP:00053789.5JAK2, F5, MTHFR, PROCR, VEGFA, IL6
6MP:00053879.4F8, JAK2, PROCR, VEGFA, IL6, VWF
7MP:00107689.3MTHFR, F5, JAK2, G6PD, F8, APOH
8MP:00053979.3F8, G6PD, JAK2, ITGA2, PROCR, VEGFA
9MP:00036319.3G6PD, F5, MTHFR, F12, VEGFA, IL6
10MP:00053768.8AQP12A, APOH, F8, G6PD, JAK2, ITGA2

Publications for Retinal Vein Occlusion

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50PubMed
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Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 953)
idTitleAuthorsYear
1
Recognizing and managing retinal vein occlusion. (24402030)
2014
2
Bilateral central retinal vein occlusion in multiple myeloma. (23561614)
2013
3
Anti-vascular endothelial growth factors in the treatment of macular oedema secondary to central retinal vein occlusion: a meta-analysis. (24330277)
2013
4
Retinal vein occlusion during flare of multicentric Castleman's disease. (23983453)
2013
5
Intravitreal ranibizumab for macular oedema secondary to retinal vein occlusion: a retrospective study of 34 eyes. (20602625)
2012
6
Intravitreal bevacizumab in macular edema secondary to branch retinal vein occlusion: 12-month results. (22888203)
2012
7
Effect of intravitreal anti-vascular endothelial growth factor treatment on the retinal gene expression in acute experimental central retinal vein occlusion. (22116547)
2012
8
Evolution of vitreomacular traction following the use of the dexamethasone intravitreal implant (Ozurdex) in the treatment of macular edema secondary to central retinal vein occlusion. (22537269)
2012
9
Potential anti-vascular endothelial growth factor therapies for central retinal vein occlusion. (23061805)
2012
10
25-gauge vitrectomy versus intravitreal bevacizumab for macular edema secondary to branch retinal vein occlusion: 1 year follow-up. (22892606)
2012
11
Predictive value of the vitamin K epoxide reductase complex subunit 1 G-1639A and C1173T single nucleotide polymorphisms in retinal vein occlusion. (22394334)
2012
12
Retinal vein occlusion in high altitude. (22206565)
2011
13
Visual function and serous retinal detachment in patients with branch retinal vein occlusion and macular edema: a case series. (21943190)
2011
14
Retinal vein occlusion and macular edema - critical evaluation of the clinical value of ranibizumab. (21750610)
2011
15
Intravitreal bevacizumab for macular edema due to central retinal vein occlusion: perfused vs. ischemic and early vs. late treatment. (21978179)
2011
16
Intravitreal injection of bevacizumab combined with macular grid laser photocoagulation for macular edema in branch retinal vein occlusion. (21909658)
2011
17
Long-term effect of early intervention with single intravitreal injection of bevacizumab followed by panretinal and macular grid photocoagulation in central retinal vein occlusion (CRVO) with macular edema: a pilot study. (21307880)
2011
18
Sustained benefits from ranibizumab for macular edema following branch retinal vein occlusion: 12-month outcomes of a phase III study. (21684606)
2011
19
Retinal vein occlusion: pathophysiology and treatment options. (20689798)
2010
20
Progression of impending central retinal vein occlusion to the ischemic variant following intravitreal bevacizumab. (20532147)
2010
21
Intravitreal bevacizumab (avastin) in the treatment of macular edema associated with perfused retinal vein occlusion. (20148661)
2010
22
Treating central retinal vein occlusion. (20214044)
2009
23
Central retinal vein occlusion in a sickle cell trait carrier after a cycling race. (19092708)
2009
24
Changes of aqueous vascular endothelial growth factor and pigment epithelium-derived factor following intravitreal bevacizumab for macular oedema secondary to branch retinal vein occlusion. (19624346)
2009
25
The Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study system for evaluation of optical coherence tomograms: SCORE study report 4. (19901211)
2009
26
A randomized trial comparing the efficacy and safety of intravitreal triamcinolone with observation to treat vision loss associated with macular edema secondary to central retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 5. (19752419)
2009
27
Central retinal vein occlusion associated with thrombotic thrombocytopenic purpura/hemolytic uremic syndrome. (18296813)
2008
28
Changes of vascular endothelial growth factor after vitrectomy for macular edema secondary to retinal vein occlusion. (18988180)
2008
29
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
30
Platelet activation by collagen is increased in retinal vein occlusion. (17264950)
2007
31
Peripheral ulcerative keratitis and central retinal vein occlusion as the initial manifestation of HIV infection. (17972227)
2007
32
Intractable glaucoma following posterior sub-tenon's triamcinolone acetonide for central retinal vein occlusion in a young adult. (16601743)
2006
33
Recurrent incomplete central retinal vein occlusion in a patient with hereditary thrombophilia]. (16848214)
2006
34
Intravitreal triamcinolone for cystoid macular edema related to branch retinal vein occlusion. (17726219)
2006
35
Intravitreal triamcinolone as primary treatment of cystoid macular edema secondary to branch retinal vein occlusion. (16077348)
2005
36
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
37
Intravitreal triamcinolone acetonide for the treatment of central retinal vein occlusion in young patients. (15097906)
2004
38
Cessation of migraine following central retinal vein occlusion. (15258240)
2004
39
Anticardiolipin antibodies in patients with retinal vein occlusion and no risk factors: a prospective study. (12972759)
2003
40
Chorioretinal anastomosis after radial optic neurotomy for central retinal vein occlusion. (14557173)
2003
41
Patchy ischemic retinal whitening in acute central retinal vein occlusion. (12414432)
2002
42
Intravitreous triamcinolone acetonide as treatment for macular edema from central retinal vein occlusion. (12215101)
2002
43
Radial optic neurotomy for central retinal vein occlusion. (12476121)
2002
44
Ischemic central retinal vein occlusion and retinitis pigmentosa: lower risk of neovascularization? (11321148)
2001
45
Retinal surgery for treatment of central retinal vein occlusion. (10743932)
2000
46
Hyperhomocysteinemia: a new risk factor for central retinal vein occlusion. (11190038)
2000
47
Capillary closure secondary to retinal vein occlusion. A morphological, histopathological, and immunohistochemical study. (9881543)
1998
48
Activated protein C resistance in central retinal vein occlusion. (9059288)
1996
49
Factor XII deficiency and central retinal vein occlusion. (1353152)
1992
50
Hyperbaric oxygen treatment for chronic cystoid macular edema after branch retinal vein occlusion. (3631188)
1987

Genetic Variations for Retinal Vein Occlusion

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Expression for genes affiliated with Retinal Vein Occlusion

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinal Vein Occlusion

Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

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Sources:
53Reactome, 12EMD Millipore, 49PharmGKB, 51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
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Pathways related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2VWF, ITGA2
2
Immune response Oncostatin M signaling via JAK-Stat in human cells
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10.2JAK2, VEGFA, IL6
310.2F12, VEGFA, PLAT
410.1HRG, PLAT, SERPINE1
5
Hide members
10.1VWF, HRG, F2
610.1ITGA2, VWF, F2
7
Hide members
10.1SERPINC1, F2, F12, F5
8
Translation Insulin regulation of translation
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10.1SERPINE1, PLAT, VEGFA, JAK2
910.0SERPINE1, PLAT, F2, IL6, MTHFR
109.9VWF, IL6, VEGFA, ITGA2, JAK2
11
Hide members
9.9F8, F5, VEGFA, VWF, HRG, SERPINE1
12
Hide members
9.8VEGFA, F12, F5, ITGA2, JAK2, F8
13
Hide members
9.7F8, F5, F12, VWF, F2, PLAT
14
Hide members
9.7SERPINC1, F8, F5, F12, VWF, F2
15
Hide members
9.6LOXL1, F8, ITGA2, F5, F12, F2

Compounds for genes affiliated with Retinal Vein Occlusion

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 185)
idCompoundScoreTop Affiliating Genes
1warfarin44 49 11 2413.6APOH, VWF, SERPINC1
2estrogen4410.6F12, APOH, F8
3creatinine4410.6APOH, F8, F5, F2
4aspartate4410.5F2, JAK2, G6PD, F8
5spectrozyme4410.5F5, SERPINC1, F2, PLAT
6pge14410.4F5, APOH, F2, PLAT, SERPINE1
7ancrod4410.4F5, F2, PLAT, SERPINC1, SERPINE1
8batroxobin4410.4PLAT, F2, F5, SERPINE1
9kaolin4410.4F2, APOH, F8, F5, F12
10fondaparinux4410.4PLAT, SERPINC1, F2, F5
11aprotinin44 1111.4F5, VWF, PLAT, SERPINE1, SERPINC1
12bivalirudin44 1111.4PLAT, F2, F5, SERPINC1
13Drotrecogin alfa1110.4SERPINE1, F8, F2, PROCR, F5
14matrigel4410.4SERPINE1, JAK2, ITGA2, HRG
15tirofiban44 1111.3PLAT, ITGA2, F2, SERPINC1, VWF
16ristocetin4410.3SERPINC1, F2, VWF, F8, F5, PLAT
17epsilon aminocaproic acid4410.3PLAT, HRG, F2, SERPINE1, SERPINC1
18tranexamic acid44 1111.3PLAT, SERPINC1, F2, VWF, F8, SERPINE1
19protamine4410.3F2, IL6, PLAT, F5, SERPINE1, SERPINC1
20argatroban44 1111.3F2, SERPINC1, PLAT, F5
2111-dehydrothromboxane b24410.3SERPINE1, VWF, APOH, F2
22cyclophosphamide44 49 1112.3VWF, MTHFR, F5, G6PD, F8, APOH
23dermatan sulfate4410.3F2, HRG, VWF, F5, SERPINC1, PLAT
24epinephrine44 11 2412.3JAK2, G6PD, VWF, F5, F2, F8
25phosphatidylethanolamine44 1111.2F8, F5, PROCR, F2, APOH
26clopidogrel49 44 11 2413.2ITGA2, SERPINC1, PLAT, F2, VWF
27desmopressin44 59 28 1113.2SERPINC1, SERPINE1, F2, PLAT, F5, VWF
28hydroxyethyl starch4410.2F8, VWF, F2, SERPINC1
29ppack4410.2F2, SERPINC1, PLAT, VWF
30gabexate mesilate4410.2SERPINC1, PLAT, F5, IL6
31simvastatin44 49 59 28 11 2415.2VEGFA, IL6, VWF, F5, PLAT, SERPINE1
32prostacyclin4410.1PLAT, VWF, VEGFA, F5, F8, APOH
33hirudin4410.1F8, SERPINE1, SERPINC1, PLAT, F2, VWF
34atorvastatin44 49 28 11 2414.1VWF, VEGFA, F5, SERPINE1, PLAT, IL6
35endotoxin4410.1SERPINE1, IL6, F5, JAK2, APOH, F8
36dextran sulfate4410.1APOH, IL6, F5, JAK2
37homocysteine44 2411.1F8, F5, MTHFR, VWF, PLAT, SERPINE1
38serine4410.1F12, PROCR, JAK2, F8, G6PD, HRG
39heparin44 28 11 2413.1MTHFR, F12, VEGFA, HRG, SERPINF1, ITGA2
40n acetylcysteine4410.0SERPINC1, VEGFA, G6PD, IL6, VWF, F2
41protamine sulfate4410.0F2, F5, PLAT, SERPINC1
42kininogen4410.0F2, PLAT, SERPINE1, SERPINC1, HRG, VWF
43phospholipid4410.0APOH, JAK2, ITGA2, F5, PROCR, F2
44cholesterol44 28 11 2412.9PLAT, VWF, F8, JAK2, F5, MTHFR
45ascorbic acid44 2410.8G6PD, JAK2, F5, MTHFR, VWF, PLAT
46nitric oxide44 11 2411.7PROCR, F8, ITGA2, SERPINF1, SERPINE1, VWF
47vegf449.7SERPINF1, VEGFA, F5, ITGA2, JAK2, APOH
48aspirin44 49 28 2412.6ITGA2, JAK2, G6PD, F8, APOH, MTHFR
49citrate449.6SERPINC1, F8, G6PD, VWF, F2, F5
50fibrinogen449.5APOH, F8, ITGA2, F5, MTHFR, F12

GO Terms for genes affiliated with Retinal Vein Occlusion

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16Gene Ontology
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Cellular components related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrixGO:0310129.8APOH, VWF, PLAT, SERPINE1, SERPINF1, LOXL1
2platelet alpha granule lumenGO:0310939.8F8, F5, VEGFA, VWF, HRG, SERPINE1
3extracellular spaceGO:0056159.3SERPINF1, LOXL1, APOH, F8, F5, F12
4extracellular regionGO:0055768.8LOXL1, F8, F5, F12, VEGFA, IL6

Biological processes related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1plasminogen activationGO:03163910.5PLAT, APOH
2negative regulation of cell adhesion mediated by integrinGO:03362910.4SERPINE1, HRG
3acute-phase responseGO:00695310.4F2, IL6, F8
4negative regulation of angiogenesisGO:01652510.3APOH, HRG, SERPINF1
5negative regulation of fibrinolysisGO:05191810.3SERPINE1, F2, HRG, APOH
6regulation of blood coagulationGO:03019310.3F2, HRG
7positive regulation of blood coagulationGO:03019410.3APOH, F12, F2, SERPINE1
8negative regulation of endopeptidase activityGO:01095110.3SERPINF1, SERPINC1, SERPINE1
9positive regulation of focal adhesion assemblyGO:05189410.3HRG, VEGFA
10blood coagulation, intrinsic pathwayGO:00759710.2APOH, F8, F12, VWF, F2
11fibrinolysisGO:04273010.2F12, HRG, F2, PLAT, SERPINE1
12positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2JAK2, VEGFA, IL6
13positive regulation of protein import into nucleus, translocationGO:03316010.2IL6, JAK2
14platelet degranulationGO:00257610.1F8, F5, VEGFA, VWF, HRG, SERPINE1
15negative regulation of blood coagulationGO:03019510.0SERPINE1, APOH
16platelet activationGO:03016810.0F8, F5, VEGFA, IL6, VWF, HRG
17blood coagulationGO:0075969.4SERPINC1, F8, JAK2, ITGA2, F5, F12

Molecular functions related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin bindingGO:01986510.2HRG, VWF
2protease bindingGO:00202010.2SERPINC1, SERPINE1, VWF
3serine-type endopeptidase inhibitor activityGO:00486710.1HRG, SERPINE1, SERPINC1, SERPINF1
4heparin bindingGO:00820110.0APOH, VEGFA, HRG, SERPINC1
5copper ion bindingGO:0055079.9F5, F8, LOXL1
6protein bindingGO:0055159.0SERPINC1, APOH, F8, G6PD, JAK2, ITGA2

Products for genes affiliated with Retinal Vein Occlusion

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Retinal Vein Occlusion

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet