MCID: RTN022
MIFTS: 56

Retinal Vein Occlusion malady

Cardiovascular diseases, Rare diseases categories

Summaries for Retinal Vein Occlusion

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Wikipedia:64 The central retinal vein is the venous equivalent of the central retinal artery and, like that blood... more...

MalaCards based summary: Retinal Vein Occlusion, also known as occlusion, of retinal vein, is related to retinal artery occlusion and central retinal vein occlusion. An important gene associated with Retinal Vein Occlusion is F5 (coagulation factor V (proaccelerin, labile factor)), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Glypican 1 network. The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include retina, eye and endothelial, and related mouse phenotypes are vision/eye and cardiovascular system.

Aliases & Classifications for Retinal Vein Occlusion

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Retinal Vein Occlusion, Aliases & Descriptions:

Name: Retinal Vein Occlusion 31 9 11 44 61
 
Occlusion, of Retinal Vein 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:1727
MeSH34 D012170
SNOMED-CT56 46085004
NCIt39 C34981

Related Diseases for Retinal Vein Occlusion

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Diseases in the Retinal Vein Occlusion family:

Central Retinal Vein Occlusion

Diseases related to Retinal Vein Occlusion via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1retinal artery occlusion31.8APOH
2central retinal vein occlusion31.7F5, PLAT, MTHFR, APOH, VEGFA
3branch retinal artery occlusion31.7F5
4macular holes31.5SERPINF1
5central retinal artery occlusion31.2PLAT
6purpura31.2SERPINC1
7retinal vascular occlusion31.1F5, APOH
8hypertension30.9F5, PLAT, MTHFR
9retinal detachment30.8VEGFA, SERPINF1, PLAT
10diabetic macular edema30.8SERPINF1, VEGFA
11lupus erythematosus30.7APOH, SERPINC1, F5
12diabetic retinopathy30.6SERPINF1, VEGFA
13sneddon syndrome30.6APOH, SERPINC1
14protein s deficiency30.6APOH, SERPINC1, MTHFR, F5
15factor xii deficiency30.6APOH, SERPINC1, F5
16eclampsia30.6MTHFR, SERPINC1
17migraine30.4MTHFR, APOH
18hyperhomocysteinemia30.4APOH, SERPINC1, MTHFR, PLAT, F5
19blindness30.4VEGFA, SERPINF1
20antithrombin iii deficiency30.3APOH, SERPINC1, MTHFR, F5
21rheumatoid arthritis30.3MTHFR, APOH, VEGFA
22age related macular degeneration30.2VEGFA, PLAT
23vascular disease30.2SERPINC1, APOH, VEGFA
24thrombophilia30.2APOH, SERPINC1, MTHFR, PLAT, F5
25hellp syndrome30.1F5, MTHFR, SERPINC1, APOH
26protein c deficiency30.1APOH, SERPINC1, MTHFR, F5
27atherosclerosis29.8PLAT, MTHFR, SERPINC1, SERPINF1, APOH
28myocardial infarction29.8SERPINC1, MTHFR, PLAT, F5
29venous thrombosis29.8APOH, SERPINC1, MTHFR, PLAT, F5
30antiphospholipid syndrome29.5APOH, SERPINC1, MTHFR, PLAT, F5
31pre-eclampsia29.2VEGFA, APOH, SERPINC1, MTHFR, PLAT, F5
32retinitis11.7
33endotheliitis10.9
34cystoid macular edema10.8
35chorioretinitis10.8
36neovascular glaucoma10.7
37choroiditis10.7
38neuropathy10.6
39ischemia10.6
40ischemic optic neuropathy10.5
41tuberculosis10.5
42thrombophlebitis10.5APOH
43vitreous detachment10.5
44thrombotic thrombocytopenic purpura10.5
45vasculitis10.5
46patent foramen ovale10.4F5
47hepatitis10.4
48leukemia10.4
49retinal ischemia10.4
50systemic lupus erythematosus10.4

Graphical network of the top 20 diseases related to Retinal Vein Occlusion:



Diseases related to retinal vein occlusion

Symptoms for Retinal Vein Occlusion

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Drugs & Therapeutics for Retinal Vein Occlusion

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Drug clinical trials:

Search ClinicalTrials for Retinal Vein Occlusion

Search NIH Clinical Center for Retinal Vein Occlusion

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Retinal Vein Occlusion cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells for retinopathy
Embryonic/Adult Cultured Cells Related to Retinal Vein Occlusion:
Bone marrow-derived hematopoietic stem cells (family), PMID: 22247454
Bone marrow-derived hematopoietic CD34+ progenitors, PMID: 22247454

Genetic Tests for Retinal Vein Occlusion

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Anatomical Context for Retinal Vein Occlusion

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MalaCards organs/tissues related to Retinal Vein Occlusion:

32
Retina, Eye, Endothelial, Bone, Myeloid, Colon, Liver, Skin, Testes, Monocytes

Animal Models for Retinal Vein Occlusion or affiliated genes

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MGI Mouse Phenotypes related to Retinal Vein Occlusion:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053917.6PLAT, MTHFR, SERPINC1, SERPINF1, VEGFA
2MP:00053857.6F5, PLAT, SERPINC1, SERPINF1, VEGFA
3MP:00053897.4VEGFA, SERPINF1, SERPINC1, MTHFR, PLAT
4MP:00053767.3VEGFA, APOH, SERPINC1, MTHFR, PLAT, F5
5MP:00036317.2VEGFA, SERPINF1, SERPINC1, MTHFR, PLAT, F5
6MP:00107687.0VEGFA, APOH, SERPINC1, MTHFR, PLAT, F5

Publications for Retinal Vein Occlusion

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Articles related to Retinal Vein Occlusion:

(show top 50)    (show all 962)
idTitleAuthorsYear
1
Mean platelet volume in retinal vein occlusion. (25339469)
2014
2
Intravitreal Aflibercept for Macular Edema Following Branch Retinal Vein Occlusion: The 24-Week Results of the VIBRANT Study. (25315663)
2014
3
The effect of antivascular endothelial growth factor therapy on the development of neovascular glaucoma after central retinal vein occlusion: a retrospective analysis. (24800060)
2014
4
Thrombophilia and vascular risk factors in retinal vein occlusion. (23566482)
2013
5
Bevacizumab for macular edema secondary to retinal vein occlusion: a systematic review and meta-analysis. (23746130)
2013
6
Vitrectomy and panretinal photocoagulation reduces the occurrence of neovascular glaucoma in central retinal vein occlusion with vitreous hemorrhage. (23114407)
2013
7
Three intravitreal bevacizumab versus two intravitreal triamcinolone injections in recent onset central retinal vein occlusion. (24373344)
2013
8
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
9
Vitreoretinal traction in impending branch retinal vein occlusion: a pathogenetic role? (22688432)
2012
10
Combined intravitreal bevacizumab and grid laser photocoagulation for macular edema secondary to branch retinal vein occlusion. (22101497)
2012
11
Branch retinal vein occlusion. (23230220)
2012
12
Myocardial infarction and cerebrovascular accident in patients with retinal vein occlusion. (21402990)
2011
13
Longer-term outcomes of a prospective study of intravitreal ranibizumab as a treatment for decreased visual acuity secondary to central retinal vein occlusion. (21317833)
2011
14
Vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in macular edema with central retinal vein occlusion. (21275514)
2011
15
Retinal vein occlusion in high altitude. (22206565)
2011
16
Correlation between spectral domain optical coherence tomography findings and visual outcomes in central retinal vein occlusion. (21468337)
2011
17
Intravitreal triamcinolone for acute branch retinal vein occlusion: a randomized clinical trial. (22454718)
2011
18
Predictors of short-term visual outcome after anti-VEGF therapy of macular edema due to central retinal vein occlusion. (21087958)
2011
19
Altered fibrin clot properties in patients with retinal vein occlusion. (21955304)
2011
20
Obstructive sleep apnea among patients with retinal vein occlusion. (21149775)
2010
21
Intravitreal injection of autologous plasmin enzyme for macular edema associated with branch retinal vein occlusion. (20801424)
2010
22
Comparison of bevacizumab and triamcinolone for treatment of macular edema secondary to branch retinal vein occlusion in a pair-matched analysis. (20424494)
2010
23
Cilioretinal artery occlusion combined with central retinal vein occlusion - a report of two cases and review of the literature. (20408080)
2010
24
Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. (20664492)
2010
25
An asymptomatic retinal vein occlusion and retinal arterial emboli in the same eye. (20935345)
2010
26
The incidence of retinal vein occlusion in the ocular hypertension treatment study. (20031222)
2010
27
Ultra wide-field angiographic characteristics of branch retinal and hemicentral retinal vein occlusion. (20045570)
2010
28
Citalopram-associated central retinal vein occlusion. (18545940)
2009
29
Branch retinal vein occlusion: pathogenesis, visual prognosis, and treatment modalities. (18293182)
2008
30
Crohn's disease complicated by granulomatous interstitial nephritis, choroidal neovascularization, and central retinal vein occlusion. (18195499)
2008
31
Long-term effect of dalteparin in the prevention of neovascularization of iris in recent-onset central retinal vein occlusion. (18759522)
2008
32
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
33
Clinical case report: treatment of a central retinal vein occlusion with hyperbaric oxygen. (18019081)
2007
34
Irreversible visual loss and optic nerve dysfunction associated with central retinal vein occlusion in Waldenstrom Macroglobulinemia. (18551947)
2007
35
Recurrent branch retinal vein occlusion with factor V leiden mutation. (16113634)
2006
36
Retinal blood flow and macular edema after radial optic neurotomy for central retinal vein occlusion. (17011887)
2006
37
Laser chorioretinal venous anastomosis for progressive nonischemic central retinal vein occlusion. (16515021)
2005
38
Retinal vein occlusion: a form of venous thrombosis or a complication of atherosclerosis? A meta-analysis of thrombophilic factors. (15968383)
2005
39
Central retinal vein occlusion secondary to an intraocular nematode. (15883297)
2005
40
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
41
Exudative retinal detachment following central retinal vein occlusion. (14762434)
2004
42
The question of radial optic neurotomy in central retinal vein occlusion. (15477488)
2004
43
Intravitreal tissue plasminogen activator in the management of central retinal vein occlusion. (14707827)
2003
44
Retinal vein occlusion in lymphomatoid papulosis. (12510725)
2002
45
Central retinal vein occlusion in bird-shot retinochoroidopathy. (12096977)
2002
46
Intravitreal injection of tissue plasminogen activator for central retinal vein occlusion. (11797310)
2001
47
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
48
Primary empty sella syndrome and central retinal vein occlusion. (7746642)
1995
49
Prognosis for rubeosis iridis following central retinal vein occlusion. (508688)
1979
50
Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. (415709)
1978

Variations for Retinal Vein Occlusion

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Expression for genes affiliated with Retinal Vein Occlusion

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Expression patterns in normal tissues for genes affiliated with Retinal Vein Occlusion

Search GEO for disease gene expression data for Retinal Vein Occlusion.

Pathways for genes affiliated with Retinal Vein Occlusion

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Pathways related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6F5, VEGFA
29.3VEGFA, SERPINC1
3
Show member pathways
thioredoxin pathway37
9.2PLAT, MTHFR
49.1PLAT, VEGFA
59.1PLAT, VEGFA
6
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
8.7SERPINC1, PLAT, F5
7
Show member pathways
8.7F5, PLAT, SERPINC1
8
Show member pathways
8.1F5, PLAT, SERPINC1, VEGFA

Compounds for genes affiliated with Retinal Vein Occlusion

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Compounds related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show top 50)    (show all 112)
idCompoundScoreTop Affiliating Genes
1inogatran449.8F5, SERPINC1
2hirugen449.7SERPINC1, F5
3verteporfin449.7SERPINF1, VEGFA
4fondaparinux449.7PLAT, F5
5ecarin449.7F5, SERPINC1
6nafamostat mesilate449.5F5, SERPINC1
7vitamin b12449.5F5, MTHFR, APOH
8uric acid44 2510.4MTHFR, APOH, F5
9dextran sulfate449.4SERPINC1, F5, APOH
10danaparoid449.4SERPINC1, F5
11integrilin449.4SERPINC1, PLAT
12reviparin449.4PLAT, SERPINC1
13efegatran449.3PLAT, SERPINC1
14batroxobin449.3F5, PLAT
15eaca449.1SERPINC1, PLAT
16pge1449.1PLAT, APOH, F5
17cyclophosphamide44 50 1211.1F5, MTHFR, APOH, VEGFA
18progestin449.1F5, SERPINC1, VEGFA
19spectrozyme449.1PLAT, F5, SERPINC1
20ancrod449.1F5, PLAT, SERPINC1
21bivalirudin44 1210.1F5, PLAT, SERPINC1
22argatroban44 1210.1SERPINC1, PLAT, F5
23gabexate mesilate449.1SERPINC1, PLAT, F5
24protamine sulfate449.1F5, SERPINC1, PLAT
25ristocetin449.1F5, SERPINC1, PLAT
26levonorgestrel44 60 29 1212.0PLAT, SERPINC1, F5
27desmopressin44 60 29 1212.0SERPINC1, PLAT, F5
28p-amino benzamidine449.0SERPINC1, PLAT
29hirudin449.0F5, SERPINC1, PLAT
30ticlopidine44 1210.0APOH, SERPINC1, PLAT
31protamine449.0F5, PLAT, SERPINC1
32folate449.0F5, APOH, SERPINC1, MTHFR
33dermatan sulfate449.0SERPINC1, PLAT, F5
34fluorescein44 129.9F5, VEGFA, SERPINF1, SERPINC1
35aprotinin44 129.9SERPINC1, PLAT, F5
36p002448.8F5, PLAT, MTHFR, APOH
37fibrinopeptide a448.7PLAT, SERPINC1
38kininogen448.7APOH, SERPINC1, PLAT, F5
39ascorbic acid44 259.6SERPINC1, PLAT, MTHFR, F5
40tamoxifen44 50 29 1211.5F5, PLAT, SERPINC1, VEGFA
41estrogen448.4VEGFA, SERPINC1, APOH, MTHFR, F5
42vegf448.4VEGFA, F5, SERPINC1, SERPINF1, APOH
43glutamate448.3F5, SERPINF1, APOH, PLAT, MTHFR
44warfarin44 50 25 1211.2F5, PLAT, MTHFR, SERPINC1, APOH
45homocysteine44 259.2SERPINC1, APOH, PLAT, F5, MTHFR
46aspirin44 50 29 2511.2MTHFR, PLAT, F5, SERPINC1, APOH
47fibrinogen448.2F5, PLAT, APOH, MTHFR, SERPINC1
48creatinine448.2APOH, SERPINC1, MTHFR, F5, PLAT
49prostacyclin448.2SERPINC1, F5, PLAT, APOH, VEGFA
50heparin44 29 25 1210.2F5, PLAT, MTHFR, SERPINC1, SERPINF1, APOH

GO Terms for genes affiliated with Retinal Vein Occlusion

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Cellular components related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.3F5, VEGFA
2secretory granuleGO:0301419.1PLAT, VEGFA
3extracellular matrixGO:0310128.7PLAT, SERPINF1, APOH
4cell surfaceGO:0099868.6VEGFA, APOH, PLAT
5extracellular regionGO:0055767.7VEGFA, SERPINF1, SERPINC1, PLAT, F5
6extracellular spaceGO:0056157.3F5, PLAT, SERPINC1, SERPINF1, APOH, VEGFA

Biological processes related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1blood circulationGO:0080159.8MTHFR, F5
2negative regulation of angiogenesisGO:0165259.7SERPINF1, APOH
3regulation of proteolysisGO:0301629.5SERPINF1, SERPINC1
4plasminogen activationGO:0316399.5PLAT, APOH
5platelet degranulationGO:0025769.5F5, VEGFA
6negative regulation of inflammatory responseGO:0507289.4SERPINC1, SERPINF1
7negative regulation of endopeptidase activityGO:0109519.3SERPINC1, SERPINF1
8kidney developmentGO:0018229.1SERPINF1, VEGFA
9response to glucocorticoidGO:0513849.1SERPINF1, PLAT
10response to hypoxiaGO:0016668.9PLAT, MTHFR, VEGFA
11blood coagulationGO:0075968.4VEGFA, SERPINC1, PLAT, F5

Molecular functions related to Retinal Vein Occlusion according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.3SERPINC1, SERPINF1
2heparin bindingGO:0082018.6SERPINC1, APOH, VEGFA

Products for genes affiliated with Retinal Vein Occlusion

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Sources for Retinal Vein Occlusion

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet