MCID: RTN023
MIFTS: 53

Retinitis malady

Eye diseases category
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Summaries for Retinitis

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Retinitis is inflammation of the retina in the eye, which may lead to blindness. Retinitis may be caused... more...

MalaCards: Retinitis, also known as retinitis nos, is related to retinitis pigmentosa and retinal degeneration. An important gene associated with Retinitis is RP1 (retinitis pigmentosa 1 (autosomal dominant)), and among its related pathways are The phototransduction cascade and Retinol metabolism. The compound 11-cis-retinol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related mouse phenotypes are pigmentation and vision/eye.

Aliases & Classifications for Retinitis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

retinitis 8 10 45 62
retinitis nos 8


External Ids:

Disease Ontology8 DOID:3612
MeSH35 D012173

Related Diseases for Retinitis

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17GeneCards, 18GeneDecks
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Diseases related to Retinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1362)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis pigmentosa31.9RP1, RHO
2retinal degeneration31.5IMPDH1, RHO, RPGRIP1, RPGR, RPE65, RP1
3blindness30.8RHO, RPGRIP1, RPGR, RPE65, RP1
4leber congenital amaurosis30.7IMPDH1, RHO, RPGRIP1, RPGR, RPE65, PRPH2
5peripheral retinal degeneration30.6RPGR
6fundus albipunctatus30.6RHO, PRPH2
7retinitis pigmentosa 230.5RP2
8nephronophthisis30.4RPGRIP1, RPGR
9retinitis pigmentosa 330.4RPGR
10night blindness30.4PRPF3, RP2, RPE65, RPGR, RHO
11congenital stationary night blindness30.3RPE65, RHO
12fundus dystrophy30.2RPE65, RPGR, RPGRIP1, RHO
13cone-rod dystrophy 230.1PRPH2, CERKL, RPE65, RPGR, RPGRIP1, RHO
14rhyns syndrome29.6IMPDH1, EYS, KLHL7, RHO, RPGRIP1, RPGR
15retinal vein occlusion11.2
16retinal detachment11.1
17retinal artery occlusion11.0
18central retinal vein occlusion11.0
19cytomegalovirus retinitis11.0
20central retinal artery occlusion10.9
21vasculitis10.9
22retinal vasculitis10.9
23ischemia10.9
24retinal ischemia10.9
25retinal disease10.9
26endotheliitis10.8
27glaucoma10.8
28choroiditis10.7
29branch retinal artery occlusion10.7
30diabetic retinopathy10.7
31neuronitis10.7
32proliferative vitreoretinopathy10.7
33uveitis10.7
34acute retinal necrosis syndrome10.7
35macular holes10.7
36retinoschisis10.6
37hypertension10.6
38age related macular degeneration10.6
39retinal vascular occlusion10.6
40cystoid macular edema10.6
41neuropathy10.6
42telangiectasis10.6
43retinal vascular disease10.6
44vascular disease10.6
45proliferative diabetic retinopathy10.5
46central serous chorioretinopathy10.5
47ocular hypertension10.5
48coloboma10.5
49hypoxia10.5
50diabetic macular edema10.5

Graphical network of the top 20 diseases related to Retinitis:



Diseases related to retinitis

Symptoms for Retinitis

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Drugs & Therapeutics for Retinitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Retinitis

Search NIH Clinical Center for Retinitis

Genetic Tests for Retinitis

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Anatomical Context for Retinitis

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33MalaCards
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MalaCards organs/tissues related to Retinitis:

33
Eye, Endothelial, Retina, Testes, T cells, Brain, Bone, Monocytes, Liver, Pineal, Bone marrow, Pituitary, Kidney, Cortex, Skin, Thyroid, B cells, Myeloid, Smooth muscle, Breast, Lung, Heart, Spleen, Prostate, Placenta, Ovary, Tongue, Pons, Lymph node, Pancreas, Nk cells, Small intestine, Colon

Animal Models for Retinitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Retinitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.2RHO, RPE65, PRPH2, PRPF3
2MP:00053917.9RHO, PRPF3, PRPH2, CERKL, RP1, RPE65

Publications for Retinitis

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Sources:
52PubMed
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Articles related to Retinitis:

(show top 50)    (show all 9588)
idTitleAuthorsYear
1
Surgical treatment for the proliferative retinal detachment associated with macular hole in the morning glory syndrome. (24404661)
2013
2
Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes. (23105016)
2013
3
Surgical repair of macular fold after vitrectomy for bullous rhegmatogenous retinal detachment. (23481455)
2013
4
The clinical characteristics of retinal vasculitis in HLA-B27-positive patients. (24102118)
2013
5
Comments on Letter to the Editor "Unilateral intravitreal dexamethazone implant for bilateral retinitis pigmentosa-related macular edema". (23996148)
2013
6
BBS1 mutations in a wide spectrum of phenotypes ranging from nonsyndromic retinitis pigmentosa to Bardet-Biedl syndrome. (23143442)
2012
7
Impending anterior ischemic optic neuropathy with elements of retinal vein occlusion in a patient on interferon for polycythemia vera. (23152654)
2012
8
Vitreoretinal traction in impending branch retinal vein occlusion: a pathogenetic role? (22688432)
2012
9
A developmental mechanism of spontaneous reattachment in rhegmatogenous retinal detachment. (22511841)
2012
10
Retinal thickening in HLA-B27-associated acute anterior uveitis: evolution with time and association with severity of inflammatory activity. (22879410)
2012
11
Calcium entry mediates hyperglycemia-induced apoptosis through Ca(2+)/calmodulin-dependent kinase II in retinal capillary endothelial cells. (23049237)
2012
12
Mutations in the I^-subunit of rod phosphodiesterase identified in consanguineous Pakistani families with autosomal recessive retinitis pigmentosa. (21655355)
2011
13
Pulmonary tuberculosis associated retinal vasculitis presenting as xanthopsia. (21428751)
2011
14
Animal models of retinal disease. (21377628)
2011
15
Heavy internal tamponade for cases with complicated retinal detachment. (21484628)
2011
16
Efficacy of wide-field digital retinal imaging for retinopathy of prematurity screening. (20796264)
2011
17
Lesions of the mitral valve as a cause of central retinal artery occlusion: presentation and discussion of two cases. (20070361)
2010
18
Analysis of autofluorescent retinal images and measurement of atrophic lesion growth in Stargardt disease. (20398653)
2010
19
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
20
A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors. (18367606)
2008
21
The zinc-binding domain of Nna1 is required to prevent retinal photoreceptor loss and cerebellar ataxia in Purkinje cell degeneration (pcd) mice. (18602413)
2008
22
MCP-1 deficiency delays regression of pathologic retinal neovascularization in a model of ischemic retinopathy. (18487365)
2008
23
Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10). (18385099)
2008
24
Beta-adrenergic receptor stimulation modulates iNOS protein levels through p38 and ERK1/2 signaling in human retinal endothelial cells. (18541234)
2008
25
EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa. (18836446)
2008
26
Central retinal vein occlusion as a possible presenting manifestation of Sneddon syndrome. (17895826)
2007
27
Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. (17159041)
2006
28
Fenretinide-induced neuronal differentiation of ARPE-19 human retinal pigment epithelial cells is associated with the differential expression of Hsp70, 14-3-3, pax-6, tubulin beta-III, NSE, and bag-1 proteins. (17110918)
2006
29
Occlusive retinal vasculitis in a patient with ankylosing spondylitis. (15999133)
2006
30
Central retinal vascular occlusion by orbital pseudotumor. (15187672)
2004
31
Central retinal vein occlusion associated with liquorice ingestion. (15180854)
2004
32
Caspase-14 is expressed in the epidermis, the choroid plexus, the retinal pigment epithelium and thymic Hassall's bodies. (12700654)
2003
33
Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium. (12506055)
2003
34
Submacular exudates with serous retinal detachment caused by cat scratch disease. (12778351)
2002
35
Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (12107411)
2002
36
Oxidative stress--induced single-strand breaks in chromosomal telomeres of human retinal pigment epithelial cells in vitro. (11481283)
2001
37
Signaling states of rhodopsin: absorption of light in active metarhodopsin II generates an all-trans-retinal bound inactive state. (11384968)
2001
38
Bilateral prepapillary loops with unilateral branch retinal artery occlusion following thrombus at the loop apex. (11217933)
2001
39
Retinal pigment epithelial tears associated with idiopathic central serous chorioretinopathy. (11340893)
2000
40
Endothelin-1-mediated retinal artery vasospasm and the rabbit electroretinogram. (10977135)
2000
41
A mutation in NRL is associated with autosomal dominant retinitis pigmentosa. (10192380)
1999
42
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
43
Activated protein C resistance in patients with central retinal vein occlusion. (9486021)
1997
44
Blood-retinal barrier breakdown following experimental retinal ischemia and reperfusion. (8654497)
1995
45
Prevalence of posterior vitreous detachment in retinitis pigmentosa. (7746622)
1995
46
The effects of naloxone on retinal ischemia in rats. (8083567)
1994
47
New ophthalmic lasers for the evaluation and treatment of retinal disease. (8260150)
1993
48
Herpesvirus antibody levels in the etiologic diagnosis of the acute retinal necrosis syndrome. (1311902)
1992
49
Retinal ischemia and cell proliferation in the rat: the role of soluble mitogens. (2338257)
1990
50
Retinal detachments occurring in cataract associated with neurodermatitis. (14932558)
1952

Variations for Retinitis

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Expression for genes affiliated with Retinitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinitis

Search GEO for disease gene expression data for Retinitis.

Pathways for genes affiliated with Retinitis

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 60Thomson Reuters
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Pathways related to Retinitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.9RHO, RPE65
2
Show member pathways
Retinol metabolism60
9.9RHO, RPE65
3
Show member pathways
9.9RHO, RPE65

Compounds for genes affiliated with Retinitis

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45Novoseek, 24HMDB
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Compounds related to Retinitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
111-cis-retinol45 2410.9RHO, RPE65

GO Terms for genes affiliated with Retinitis

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16Gene Ontology
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Cellular components related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonemeGO:00593010.0RP1, RPGRIP1
2photoreceptor inner segmentGO:0019179.7RP1, RHO
3photoreceptor outer segmentGO:0017509.7RP1, RPGR, RHO
4photoreceptor connecting ciliumGO:0323918.9TOPORS, FAM161A, RP1
5ciliary basal bodyGO:0360648.7TOPORS, FAM161A, RP2, RPGR

Biological processes related to Retinitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1retina development in camera-type eyeGO:0600419.9PRPH2, RPGRIP1, RHO
2photoreceptor cell outer segment organizationGO:0358459.9TOPORS, RP1
3retinoid metabolic processGO:0015239.9RPE65, RHO
4eye photoreceptor cell developmentGO:0424629.9RPGRIP1, RPGR
5retinal cone cell developmentGO:0465499.8RP1, TOPORS
6phototransduction, visible lightGO:0076039.8RP1, RHO, RPE65
7retinal rod cell developmentGO:0465489.7RP1, TOPORS
8response to stimulusGO:0508969.3RPGR, FAM161A, RPGRIP1
9RNA splicingGO:0083808.9PRPF3, SNRNP200, RP9
10visual perceptionGO:0076018.0RP1, FAM161A, RHO, RPGRIP1, RPGR, RPE65

Molecular functions related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:0055156.0RHO, TOPORS, FAM161A, PRPF3, SNRNP200, RP2

Products for genes affiliated with Retinitis

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Sources for Retinitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet