MCID: RTN023
MIFTS: 61

Retinitis malady

Summaries for Retinitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Retinitis is inflammation of the retina in the eye, which may lead to blindness. Retinitis may be caused... more...

MalaCards: Retinitis, also known as retinitis nos, is related to retinitis pigmentosa and retinal degeneration. An important gene associated with Retinitis is PRPH2 (peripherin 2 (retinal degeneration, slow)), and among its related pathways are Signaling by GPCR and Visual phototransduction. The compounds vitamin a and 11-cis-retinol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Retinitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

retinitis 8 10 44 60
retinitis nos 8


External Ids:

Disease Ontology8 DOID:3612
MeSH34 D012173

Related Diseases for Retinitis

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17GeneCards, 18GeneDecks
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Diseases related to Retinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1261)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis pigmentosa31.7RHO, RP1
2retinal degeneration31.6RP1, RPE65, RP2, RPGR, PITPNM1, RHO
3retinal disease31.6FSCN2, ROM1, ABCA4, NRL, PRPH2, RHO
4age related macular degeneration30.9RHO
5leber congenital amaurosis30.7PRPH2, RPE65, NRL, RPGR, RHO
6stargardt disease30.6ABCA4, RHO
7peripheral retinal degeneration30.4RPGR, ROM1
8eye disease30.4RHO, ABCA4
9rhyns syndrome30.4RP9, RP1, RPE65, RPGR, RHO, PRPH2
10fundus albipunctatus30.4RHO, PRPH2
11night blindness30.3ABCA4, RHO, RPGR, RPE65, RP2
12fundus dystrophy30.2ROM1, RPGR, RPE65, RHO, ABCA4
13vitelliform macular dystrophy30.1ROM1, PRPH2
14cone-rod dystrophy 230.1RHO, RPGR, RPE65, PRPH2, CERKL, ABCA4
15congenital stationary night blindness30.1RHO, RPE65
16retinitis pigmentosa 330.1RPGR
17retinitis pigmentosa 229.8RP2
18retinal detachment11.1
19retinal vein occlusion11.1
20retinal artery occlusion11.0
21central retinal vein occlusion11.0
22central retinal artery occlusion10.9
23macular retinal edema10.9
24retinal vasculitis10.9
25retinal ischemia10.8
26vasculitis10.8
27ischemia10.8
28branch retinal artery occlusion10.7
29glaucoma10.7
30choroiditis10.7
31diabetic retinopathy10.7
32retinal vascular occlusion10.7
33neuronitis10.7
34proliferative vitreoretinopathy10.7
35acute retinal necrosis syndrome10.6
36uveitis10.6
37macular holes10.6
38retinoschisis10.6
39hypertension10.6
40retinal vascular disease10.6
41vascular disease10.6
42vitreous detachment10.6
43cystoid macular edema10.6
44neuropathy10.5
45telangiectasis10.5
46proliferative diabetic retinopathy10.5
47coloboma10.5
48diabetic macular edema10.5
49ocular hypertension10.5
50hemangioma10.5

Graphical network of the top 20 diseases related to Retinitis:



Diseases related to retinitis

Clinical Features for Retinitis

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Drugs & Therapeutics for Retinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Retinitis

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Genetic Tests for Retinitis

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Anatomical Context for Retinitis

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32MalaCards
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MalaCards organs/tissues related to Retinitis:

32
Eye, Endothelial, Retina, Testes, T cells, Brain, Bone, Monocytes, Liver, Bone marrow, Cortex, Pineal, Kidney, Pituitary, Skin, B cells, Myeloid, Thyroid, Smooth muscle, Breast, Heart, Lung, Prostate, Ovary, Spleen, Placenta, Tongue, Nk cells, Pancreas, Colon, Small intestine, Lymph node, Pons

Animal Models for Retinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539113.7RP1, SLC24A2, RGR, FSCN2, ROM1, ABCA4
2MP:000363112.8SLC24A2, GUCY2F, PRPH2, RHO, ABCA4, RD3
3MP:000118611.4RHO, ABCA4, PRPH2, RPE65

Publications for Retinitis

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Sources:
50PubMed
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Articles related to Retinitis:

(show top 50)    (show all 9685)
idTitleAuthorsYear
1
Relationship between Visual Acuity and Spectral Domain Optical Coherence Tomography Retinal Parameters in Neovascular Age-Related Macular Degeneration. (24107542)
2014
2
Cytomegalovirus retinitis in a patient with proliferative diabetes retinopathy. (23480605)
2013
3
Glucose-6-phosphate dehydrogenase deficiency and diabetes mellitus with severe retinal complications in a sardinian population, Italy. (24324368)
2013
4
Synergistic protective effects of escin and lowa89dose glucocorticoids on blooda89retinal barrier breakdown in a rat model of retinal ischemia. (23525122)
2013
5
Structural recovery of the detached macula after retinal detachment repair as assessed by optical coherence tomography. (23730110)
2013
6
Stimulating retinal blood vessel protection with hypoxia-inducible factor stabilization: identification of novel small-molecule hydrazones to inhibit hypoxia-inducible factor prolyl hydroxylase (an american ophthalmological society thesis). (24385673)
2013
7
Systemic corticosteroids reduce the risk of cellophane membranes after retinal detachment surgery: a prospective randomized placebo-controlled double-blind clinical trial. (22270216)
2012
8
Bilateral Exudative Retinal Detachment in HELLP Syndrome. (22615699)
2012
9
Antiangiogenic isoforms of vascular endothelial growth factor predominate in subretinal fluid of patients with rhegmatogenous retinal detachment and proliferative vitreoretinopathy. (21836532)
2012
10
Ranibizumab: in macular oedema following retinal vein occlusion. (21395358)
2011
11
Anatomy and function of the macula in patients after retinectomy for retinal detachment complicated by proliferative vitreoretinopathy. (21140368)
2011
12
Radial optic neurotomy in central retinal vein occlusion does not influence ocular hemodynamics. (20693821)
2011
13
Effect of host genetics on the development of cytomegalovirus retinitis in patients with AIDS. (20617924)
2010
14
Visual improvement in established central retinal vein occlusion with long-standing macular edema following systemic eculizumab treatment. (20935688)
2010
15
An unusual retinal phenotype associated with a novel mutation in RHO. (20697005)
2010
16
Intravitreal l-Arginine injection reverses the retinal arteriolar vasoconstriction that occurs after experimental acute branch retinal vein occlusion. (20457153)
2010
17
Intravitreal pegaptanib sodium (Macugen) for refractory cystoid macular edema in pericentral retinitis pigmentosa. (18157710)
2009
18
Pupil campimetry in patients with retinitis pigmentosa and functional visual field loss. (19096865)
2009
19
Republished review. [corrected] Late-onset retinal macular degeneration: clinical insights into an inherited retinal degeneration. (19734518)
2009
20
Atherosclerotic and thrombophilic risk factors in patients with recurrent central retinal vein occlusion. (18320516)
2008
21
Serum differentially modifies the transcription and translation of NMDAR subunits in retinal neurons. (18270826)
2008
22
Changes of vascular endothelial growth factor after vitrectomy for macular edema secondary to retinal vein occlusion. (18988180)
2008
23
Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments. (17292886)
2007
24
Dominant retinitis pigmentosa phenotype associated with a new mutation in the splicing factor PRPF31. (17895420)
2007
25
Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ. (17562394)
2007
26
Inhibition of nNOS and COX-2 expression by lutein in acute retinal ischemia. (16631350)
2006
27
Treatment of acute retinal necrosis syndrome. (16969431)
2006
28
Ganciclovir implant in the treatment of cytomegalovirus retinitis. (16293081)
2005
29
Three families displaying the combination of Stargardt's disease with cone-rod dystrophy or retinitis pigmentosa. (15019334)
2004
30
Concurrent enhancement of transcriptional activity and specificity of a retinal pigment epithelial cell-preferential promoter. (15064682)
2004
31
Retinal detachment in focal dermal hypoplasia. (15134118)
2004
32
Integrin alphavbeta5 is not required for the phagocytosis of photoreceptor outer segments by cultured retinal pigment epithelial cells. (12907160)
2003
33
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. (12606527)
2003
34
Assessment of retinal structure and function in Ames waltzer mice. (12939319)
2003
35
Endogenous fungal retinitis in a patient with acute lymphocytic leukemia manifesting as uveitis and optic nerve lesion. (12470157)
2002
36
Transient retinal ischemia-reperfusion in rats. (11776107)
2000
37
The prothrombin gene G20210A mutation and the platelet glycoprotein IIIa polymorphism PlA2 in patients with central retinal vein occlusion. (10593436)
1999
38
Indocyanine green angiographic imaging of central retinal artery occlusion with cilioretinal sparing. (10696342)
1999
39
Intravitreal and plasma cidofovir concentrations after intravitreal and intravenous administration in AIDS patients with cytomegalovirus retinitis. (9572540)
1998
40
Production of platelet-derived growth factor by interleukin-1 beta and transforming growth factor-beta-stimulated retinal pigment epithelial cells leads to contraction of collagen gels. (9112977)
1997
41
Redistribution of GABA immunoreactivity following central retinal artery occlusion. (7552261)
1995
42
Autosomal dominant spinocerebellar atrophy with retinal degeneration. (7614091)
1995
43
Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase. (7493036)
1995
44
Mutations in the human retinal degeneration slow (RDS) gene can cause either retinitis pigmentosa or macular dystrophy. (8485576)
1993
45
Correlation of electroretinographic changes with visual prognosis in central retinal artery occlusion. (8278170)
1993
46
Optic disc coloboma associated with macular hole and retinal detachment. (8297073)
1993
47
Laser photocoagulation of retinal neovascularization in intermediate uveitis. (1730365)
1992
48
Retinal cyclic-GMP phosphodiesterase gamma-subunit: use of mutant synthetic peptides to define function. (1659809)
1991
49
A reduced incidence of cystoid macular edema following retinal detachment surgery using diathermy. (4047603)
1985
50
Bilateral exudative retinal detachment in eclampsia without hypertensive retinopathy. (7446666)
1980

Genetic Variations for Retinitis

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Expression for genes affiliated with Retinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinitis

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Pathways for genes affiliated with Retinitis

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Retinitis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Retinitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2413.6RPE65, RDH11, RHO, ABCA4, RGR
211-cis-retinol44 2412.4RGR, ABCA4, RHO, RPE65
3cgmp44 2812.1RHO, GUCY2F, RPGR
4retinoid4411.1RGR, ABCA4, RHO, RPE65
5gramicidin4410.8RHO, SLC24A1

GO Terms for genes affiliated with Retinitis

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16Gene Ontology
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Cellular components related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.7ABCA4, GUCY2F, RHO, ROM1, RGR, SLC24A1
2photoreceptor disc membraneGO:09738111.2GUCY2F, RHO, ABCA4
3photoreceptor outer segmentGO:00175011.1RHO, RPGR, RP1
4photoreceptor inner segmentGO:00191710.9RHO, RP1
5photoreceptor outer segment membraneGO:04262210.6ROM1, RHO

Biological processes related to Retinitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760114.3ABCA4, NRL, PRPH2, RHO, GUCY2F, RD3
2phototransduction, visible lightGO:00760312.3RP1, RPE65, RDH11, GUCY2F, RHO, ABCA4
3response to stimulusGO:05089611.6RAX2, RD3, RPGR, NRL
4retinoid metabolic processGO:00152311.6ABCA4, RDH11, RHO, RPE65
5rhodopsin mediated signaling pathwayGO:01605611.3GUCY2F, RHO, SLC24A1
6retina development in camera-type eyeGO:06004111.3RD3, PRPH2, RHO
7regulation of rhodopsin gene expressionGO:00746811.1RPE65, NRL
8retinal rod cell developmentGO:04654811.1RP1, NRL
9retinal metabolic processGO:04257411.0RPE65, RDH11
10protein-chromophore linkageGO:01829811.0RHO, RGR
11eye photoreceptor cell developmentGO:04246210.9RPGR, FSCN2
12regulation of rhodopsin mediated signaling pathwayGO:02240010.9GUCY2F, RHO
13phototransductionGO:00760210.8RGR, PITPNM1
14photoreceptor cell maintenanceGO:04549410.6RP1, ABCA4

Molecular functions related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:00988110.9RGR, RHO

Products for genes affiliated with Retinitis

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Sources for Retinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet