MCID: RTN023
MIFTS: 61

Retinitis malady

Summaries for Retinitis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Retinitis is inflammation of the retina in the eye, which may lead to blindness. Retinitis may be caused... more...

MalaCards: Retinitis, also known as retinitis nos, is related to retinitis pigmentosa and retinal degeneration. An important gene associated with Retinitis is PRPH2 (peripherin 2 (retinal degeneration, slow)), and among its related pathways are Signaling by GPCR and Visual phototransduction. The compounds vitamin a and 11-cis-retinol have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related mouse phenotypes are vision/eye and nervous system.

Aliases & Classifications for Retinitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

retinitis 8 10 44 60
retinitis nos 8


External Ids:

Disease Ontology8 DOID:3612
MeSH34 D012173

Related Diseases for Retinitis

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17GeneCards, 18GeneDecks
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Diseases related to Retinitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1261)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis pigmentosa31.7RHO, RP1
2retinal degeneration31.6RP1, RPE65, RP2, RPGR, PITPNM1, RHO
3retinal disease31.6FSCN2, ROM1, ABCA4, NRL, PRPH2, RHO
4age related macular degeneration30.9RHO
5leber congenital amaurosis30.7PRPH2, RPE65, NRL, RPGR, RHO
6stargardt disease30.6ABCA4, RHO
7peripheral retinal degeneration30.4RPGR, ROM1
8eye disease30.4RHO, ABCA4
9rhyns syndrome30.4RP9, RP1, RPE65, RPGR, RHO, PRPH2
10fundus albipunctatus30.4RHO, PRPH2
11night blindness30.3ABCA4, RHO, RPGR, RPE65, RP2
12fundus dystrophy30.2ROM1, RPGR, RPE65, RHO, ABCA4
13vitelliform macular dystrophy30.1ROM1, PRPH2
14cone-rod dystrophy 230.1RHO, RPGR, RPE65, PRPH2, CERKL, ABCA4
15congenital stationary night blindness30.1RHO, RPE65
16retinitis pigmentosa 330.1RPGR
17retinitis pigmentosa 229.8RP2
18retinal detachment11.1
19retinal vein occlusion11.1
20retinal artery occlusion11.0
21central retinal vein occlusion11.0
22central retinal artery occlusion10.9
23macular retinal edema10.9
24retinal vasculitis10.9
25retinal ischemia10.8
26vasculitis10.8
27ischemia10.8
28branch retinal artery occlusion10.7
29glaucoma10.7
30choroiditis10.7
31diabetic retinopathy10.7
32retinal vascular occlusion10.7
33neuronitis10.7
34proliferative vitreoretinopathy10.7
35acute retinal necrosis syndrome10.6
36uveitis10.6
37macular holes10.6
38retinoschisis10.6
39hypertension10.6
40retinal vascular disease10.6
41vascular disease10.6
42vitreous detachment10.6
43cystoid macular edema10.6
44neuropathy10.5
45telangiectasis10.5
46proliferative diabetic retinopathy10.5
47coloboma10.5
48diabetic macular edema10.5
49ocular hypertension10.5
50hemangioma10.5

Graphical network of the top 20 diseases related to Retinitis:



Diseases related to retinitis

Clinical Features for Retinitis

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Drugs & Therapeutics for Retinitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Retinitis

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Genetic Tests for Retinitis

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Anatomical Context for Retinitis

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32MalaCards
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MalaCards organs/tissues related to Retinitis:

32
Eye, Endothelial, Retina, Testes, T cells, Brain, Bone, Monocytes, Liver, Bone marrow, Pineal, Cortex, Pituitary, Kidney, Skin, B cells, Myeloid, Thyroid, Smooth muscle, Lung, Heart, Breast, Prostate, Placenta, Ovary, Spleen, Small intestine, Lymph node, Tongue, Pons, Colon, Pancreas, Nk cells

Animal Models for Retinitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539113.7CERKL, RP1, RPE65, RPGR, RDH11, RD3
2MP:000363112.8RP1, RPE65, RPGR, RD3, GUCY2F, RHO
3MP:000118611.4ABCA4, PRPH2, RHO, RPE65

Publications for Retinitis

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50PubMed
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Articles related to Retinitis:

(show top 50)    (show all 9685)
idTitleAuthorsYear
1
Directional protein secretion by the retinal pigment epithelium: roles in retinal health and the development of age-related macular degeneration. (23663427)
2013
2
Oral fluoroquinolone use and retinal detachment: reconciling conflicting findings in observational research. (24281459)
2013
3
The influence of NaIO(3)-induced retinal degeneration on intra-retinal layer and the changes of expression profile/morphology of DA-ACs and mRGCS. (23143922)
2013
4
Stem cells set their sights on retinitis pigmentosa. (23991287)
2013
5
A Pre-Retinal Arterial Loop Causing a Branch Retinal Artery Occlusion. (24256988)
2013
6
Simple hybrid method for fine microaneurysm detection from non-dilated diabetic retinopathy retinal images. (23777979)
2013
7
Differential effect of long versus short wavelength light exposure on pupillary re-dilation in patients with outer retinal disease. (21883771)
2012
8
Unilateral optic neuritis, scleritis and exudative retinal detachment due to recurrent orbital pseudotumor. (23961032)
2012
9
Prospective study of a fluocinolone acetonide implant for chronic macular edema from central retinal vein occlusion: thirty-six-month results. (21924503)
2012
10
PET-CT aids in the diagnosis of a choroidal mass with retinal detachment in a patient with history of breast cancer and sarcoidosis. (22605712)
2012
11
Gene mapping and mutation screening in candidate genes in a Chinese family of autosomal dominant retinitis pigmentosa. (22567862)
2012
12
Test-retest, within-visit variability of Goldmann visual fields in retinitis pigmentosa. (21896857)
2011
13
Reappraisal of maximal paracentesis in central retinal artery occlusion. (19925525)
2011
14
Heavy versus standard silicone oil in the management of retinal detachment with macular hole in myopic eyes. (21124256)
2011
15
Atherosclerotic and thrombophilic risk factors in patients with ischemic central retinal vein occlusion. (21178660)
2011
16
Ocular Tuberculosis Initially Presenting as Central Retinal Vein Occlusion. (21116342)
2010
17
Altered expression of retinal molecular markers in the canine RPE65 model of Leber congenital amaurosis. (20671290)
2010
18
Combining coma with astigmatism can improve retinal image over astigmatism alone. (20659497)
2010
19
Minor surgery for the repair of retinal detachment emanating from retinoschisis. (18937819)
2009
20
Ophthalmic complications including retinal detachment in hyperimmunoglobulinemia E (Job's) syndrome: Case report and review of literature. (19700878)
2009
21
Differential gene expression in Ndph-knockout mice in retinal development. (18978344)
2009
22
Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells. (19071111)
2009
23
Central retinal vein occlusion after liver transplantation. (18547276)
2009
24
Tractional retinal detachment following intravitreal bevacizumab (Avastin) in patients with severe proliferative diabetic retinopathy. (17965108)
2008
25
Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice. (19050768)
2008
26
Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration. (17664227)
2007
27
Flicker assessment of rod and cone function in a model of retinal degeneration. (17674067)
2007
28
A population-based epidemiological and genetic study of X-linked retinitis pigmentosa. (17724181)
2007
29
Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation. (17122147)
2006
30
Branch retinal artery occlusion during coronary angiography. (16272234)
2005
31
Central retinal artery occlusion: visual outcome. (16138997)
2005
32
Unoprostone isopropyl rescues retinal progenitor cells from apoptosis in vitro. (15764090)
2004
33
Retinal arterial wall plaques in Susac syndrome. (12654364)
2003
34
Mutations of RPGR in X-linked retinitis pigmentosa (RP3). (11968081)
2002
35
Imaging of the optic disc and retinal nerve fiber layer: the effects of age, optic disc area, refractive error, and gender. (11778725)
2002
36
Nucleotide binding domain 1 of the human retinal ABC transporter functions as a general ribonucleotidase. (11444963)
2001
37
Successful erbium: YAG laser-induced chorioretinal venous anastomosis for the management of ischemic central retinal vein occlusion. A report of two cases. (11789869)
2001
38
The formation and involution of optociliary veins during the course of central retinal vein occlusion. (10913654)
2000
39
Dorsal retinal pigment epithelium differentiates as neural retina in the microphthalmia (mi/mi) mouse. (10711712)
2000
40
Vasoproliferative retinal tumors associated with peripheral chorioretinal scars in presumed congenital toxoplasmosis. (10654174)
1999
41
Expression of interferon-gamma in the lens exacerbates anterior uveitis and induces retinal degenerative changes in transgenic Lewis rats. (10227812)
1999
42
Branch retinal artery occlusion by diathermy of a persistent hyaloid artery. (9439377)
1997
43
Mapping the RP2 locus for X-linked retinitis pigmentosa on proximal Xp: a genetically defined 5-cM critical region and exclusion of candidate genes by physical mapping. (8938433)
1996
44
Intermediate uveitis and retinal vasculitis as manifestations of cat scratch disease. (8862061)
1996
45
Developmental appearance, species and tissue specificity of mouse 23-kDa, a retinal calcium-binding protein (recoverin). (8405185)
1993
46
Microcatheter urokinase infusion in central retinal artery occlusion. (1558118)
1992
47
Central retinal artery occlusion after local anesthesia for blepharoplasty. (1765303)
1991
48
Idiopathic juxtafoveolar retinal telangiectasis. (7082207)
1982
49
Delayed visual evoked cortical potentials in retinal disease. (7158314)
1982
50
Homocarnosinosis. 2. A familial metabolic disorder associated with spastic paraplegia, progressive mental deficiency, and retinal pigmentation. (1266573)
1976

Genetic Variations for Retinitis

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Expression for genes affiliated with Retinitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinitis

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Pathways for genes affiliated with Retinitis

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53Reactome, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 12EMD Millipore
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Compounds for genes affiliated with Retinitis

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44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR
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Compounds related to Retinitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1vitamin a44 11 2413.6RPE65, RDH11, RHO, ABCA4, RGR
211-cis-retinol44 2412.4RGR, ABCA4, RHO, RPE65
3cgmp44 2812.1RHO, GUCY2F, RPGR
4retinoid4411.1RGR, ABCA4, RHO, RPE65
5gramicidin4410.8RHO, SLC24A1

GO Terms for genes affiliated with Retinitis

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16Gene Ontology
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Cellular components related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.7GUCY2F, RHO, ABCA4, ROM1, RGR, SLC24A1
2photoreceptor disc membraneGO:09738111.2ABCA4, RHO, GUCY2F
3photoreceptor outer segmentGO:00175011.1RHO, RPGR, RP1
4photoreceptor inner segmentGO:00191710.9RHO, RP1
5photoreceptor outer segment membraneGO:04262210.6ROM1, RHO

Biological processes related to Retinitis according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1visual perceptionGO:00760114.3SLC24A2, RP1, RPE65, RP2, RPGR, RD3
2phototransduction, visible lightGO:00760312.3RP1, RPE65, RDH11, GUCY2F, RHO, ABCA4
3response to stimulusGO:05089611.6RPGR, RD3, NRL, RAX2
4retinoid metabolic processGO:00152311.6ABCA4, RHO, RDH11, RPE65
5rhodopsin mediated signaling pathwayGO:01605611.3SLC24A1, RHO, GUCY2F
6retina development in camera-type eyeGO:06004111.3PRPH2, RHO, RD3
7regulation of rhodopsin gene expressionGO:00746811.1RPE65, NRL
8retinal rod cell developmentGO:04654811.1RP1, NRL
9retinal metabolic processGO:04257411.0RDH11, RPE65
10protein-chromophore linkageGO:01829811.0RGR, RHO
11eye photoreceptor cell developmentGO:04246210.9RPGR, FSCN2
12regulation of rhodopsin mediated signaling pathwayGO:02240010.9RHO, GUCY2F
13phototransductionGO:00760210.8RGR, PITPNM1
14photoreceptor cell maintenanceGO:04549410.6ABCA4, RP1

Molecular functions related to Retinitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1photoreceptor activityGO:00988110.9RGR, RHO

Products for genes affiliated with Retinitis

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Sources for Retinitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet