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RB
MCID: RTN024

Retinoblastoma malady
3 drugs, 568 genes, 30 tissues, 973 related diseases, 28 phenotypes, 1271 articles, clinical trials, genetic tests.

Summaries for Retinoblastoma

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6Disease Ontology, 30NIH Rare Diseases, 17Genetics Home Reference, 15GeneReviews, 22MalaCards
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NIH Rare Diseases: Retinoblastoma (RB) is a rare type of eye cancer in the retina that typically develops before the age of 5. It usually affects only one eye, but 1/3 of children with RB develop cancer in both eyes. The first sign is typically a visible whiteness in the pupil called "cat's eye reflex" or leukocoria, which is particularly noticeable in photographs taken with a flash. Other signs and symptoms include strabismus; persistent eye pain, redness or irritation; and blindness or poor vision in the affected eye(s). Retinoblastoma30

MalaCards: Retinoblastoma, also known as RB, is related to carcinoma and leukemia. An important gene associated with Retinoblastoma is RB1 (retinoblastoma 1), and among its related pathways are Pancreatic Adenocarcinoma and Cell cycle. The drugs carmustine and cyclophosphamide and the compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and retina, and related mouse phenotypes are growth/size and mortality/aging.

Disease Ontology: A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives from the tissues of the retina.6

Genetics Home Reference: Retinoblastoma is a rare type of eye cancer that usually develops in early childhood, typically before the age of 5. This form of cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.17

Wikipedia: Retinoblastoma (Rb) is a rapidly developing cancer that develops in the cells of retina, the...44 more...

GeneReviews summary for retinoblastoma

Aliases & Descriptions for Retinoblastoma

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6Disease Ontology, 7diseasecard, 44Wikipedia, 15GeneReviews, 30NIH Rare Diseases, 16GeneTests, 17Genetics Home Reference, 8DISEASES, 32Novoseek , 43UMLS, 33OMIM, 40SNOMED-CT, 27NCIt, 24MeSH
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Aliases & Descriptions:

retinoblastoma 6 7 44 15 30 17 8 32 43
rb 6 44 30 17
retinoblastoma (disorder) 6 16
glioma, retinal 44 17
retinoblastoma nos (morphologic abnormality) 6
retinoblastomas (morphologic abnormality) 6
retinoblastoma (morphologic abnormality) 6
eye cancer, retinoblastoma 30
neuroblastoma of retina 6
neuroblastoma, retinal 44
malignant tumor of eye 43
glioblastoma, retinal 44
central neuroblastoma 43
rb - retinoblastoma 6
retinal cancer 30
retinal tumor 30
glioblastoma 43
eye cancer 17
glioma 43

Related Diseases for Retinoblastoma

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13GeneCards, 14GeneDecks
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Diseases related to retinoblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 970)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma71.8PIK3CA, PIK3CG, NDC80, NDN, RFC1, NCAM1
2leukemia64.3ZNF22, PIK3CA, PIK3CG, RFC1, NCAM1, NCL
3prostatitis61.2PIK3CA, PIK3CG, NDN, RFC1, NCAM1, NCL
4neuronitis59.5PIK3CA, PIK3CG, NDN, NCAM1, NCL, PDE3B
5melanoma57.7PIK3CA, PIK3CG, NDN, NCAM1, NCL, PDE3B
6thyroiditis55.3PIK3CA, PIK3CG, NDN, RFC1, NCAM1, NCOA6
7adenocarcinoma54.2PIK3CA, PIK3CG, NDN, NCAM1, NCL, RECK
8breast carcinoma53.2PIK3CA, PIK3CG, NDC80, NCL, RECK, KIT
9hepatocellular carcinoma52.6PIK3CA, PIK3CG, NCAM1, NCL, RECK, RELN
10pancreatitis52.0PIK3CA, PIK3CG, NCAM1, NCL, PDE3B, RECK
11sarcoma51.1PIK3CA, PIK3CG, NCAM1, RECK, KIT, KITLG
12colorectal cancer51.1ZNF22, PIK3CA, PIK3CG, RFC1, NCAM1, NCOA6
13neuroblastoma50.6PIK3CA, PIK3CG, NDN, NCAM1, NCL, PDE3B
14lung carcinoma50.2PIK3CA, PIK3CG, NCAM1, RECK, RCVRN, PCNA
15cervicitis49.9PIK3CA, PIK3CG, RFC1, NCL, RECK, KIT
16hepatitis48.7PIK3CA, PIK3CG, NCAM1, NCL, NCOA6, PDE3B
17osteosarcoma47.7PIK3CA, PIK3CG, RFC1, PDE3B, RECK, KIT
18esophagitis46.9PIK3CA, PIK3CG, NCAM1, RECK, RELN, CNTN1
19myeloid leukemia46.7PIK3CA, PIK3CG, NCAM1, NCL, RECK, KIT
20retinitis46.5PIK3CA, PIK3CG, PDE3B, KIT, KITLG, VSX2
21ovarian carcinoma46.4PIK3CA, PIK3CG, NDN, RECK, KIT, RCVRN
22hypoxia46.3PIK3CA, PIK3CG, NDN, RECK, KIT, KITLG
23colon cancer46.1PIK3CA, PIK3CG, RFC1, NCAM1, RECK, PCNA
24gastric cancer45.5PIK3CA, PIK3CG, NDC80, RFC1, NCL, RECK
25astrocytoma43.3PIK3CA, PIK3CG, NCAM1, PDE3B, RECK, KIT
26myeloma43.3PIK3CA, PIK3CG, NCAM1, RECK, KIT, KITLG
27adenoma43.2PIK3CA, NCAM1, RECK, KIT, KITLG, SFRP2
28acute myeloid leukemia42.7PIK3CA, PIK3CG, NCAM1, NCL, RECK, KIT
29cervical cancer42.4PIK3CA, PIK3CG, RFC1, NCL, SFRP2, PCNA
30alzheimer's disease41.5PIK3CA, PIK3CG, RFC1, NCAM1, NCL, RECK
31epithelial ovarian cancer41.0PIK3CA, PIK3CG, RB1, RBBP8, NBN, SERPINB2
32oral squamous cell carcinoma40.7PIK3CA, RECK, SFRP2, PCNA, RB1, RBL2
33endometrial cancer40.4PIK3CA, PIK3CG, NDC80, KITLG, PCNA, RB1
34endometrial carcinoma40.4PIK3CA, PIK3CG, KIT, PCNA, RB1, SERPINB2
35multiple myeloma40.3PIK3CA, PIK3CG, NCAM1, RECK, KIT, KITLG
36cholesterol39.9PIK3CA, PIK3CG, NDN, NCOA6, PDE3B, RECK
37lymphocytic leukemia39.8PIK3CA, PIK3CG, NCAM1, NCL, PDE3B, RECK
38medulloblastoma39.1PIK3CA, PIK3CG, NCAM1, KIT, SFRP2, PCNA
39cervical carcinoma39.1PIK3CA, PIK3CG, RECK, KIT, KITLG, PCNA
40schizophrenia39.0PIK3CA, PIK3CG, NCAM1, RELN, KIF13A, PCNA
41lymphoblastic leukemia38.9PIK3CA, PIK3CG, RFC1, NCAM1, RECK, KIT
42meningioma38.9PIK3CG, RFC1, NCAM1, NCL, PCNA, RB1
43tuberculosis38.8PIK3CG, PDE3B, RB1, RBBP8, VIM, VEGFA
44cerebritis38.5PIK3CG, NCAM1, RELN, KITLG, PCNA, SERPINB2
45non-small cell lung carcinoma38.3NCAM1, RCVRN, PCNA, RB1, VEGFA, VEGFC
46acute leukemia38.2PIK3CA, NCAM1, NCL, KIT, KITLG, RB1
47esophageal cancer38.0PIK3CA, PIK3CG, CNTN1, KITLG, PCNA, RB1
48esophageal squamous cell carcinoma37.8PIK3CA, NCAM1, RECK, KIT, PCNA, RB1
49colon carcinoma37.8PIK3CA, PIK3CG, NCAM1, NCL, KIT, KITLG
50fibrosis37.6PIK3CA, PIK3CG, RECK, KIT, KITLG, PCNA

Graphical network of the top 20 diseases related to retinoblastoma:



Graphical network of diseases related to retinoblastoma

Clinical Features for Retinoblastoma

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Drugs & Therapeutics for Retinoblastoma

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for retinoblastoma

Drug clinical trials:

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Search CenterWatch for retinoblastoma

Inferred drug relations via UMLS/NDF-RT:

43 28 carmustine, cyclophosphamide, dactinomycin

Genetic Tests for Retinoblastoma

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16GeneTests
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Genetic tests related to retinoblastoma:

id Genetic test Affiliating Genes
1 Retinoblastoma
clinical/research 		RB1

Anatomical Context for Retinoblastoma

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22MalaCards
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MalaCards organs/tissues related to retinoblastoma:

22
Bone marrow, Brain, Retina, Spinal cord, Smooth muscle, Small intestine, Colon, Adipocyte, Liver, Lung, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Placenta, Prostate, Testis, Cervix, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Pancreatic islet, Pineal, Pituitary, Testis germ

Phenotypes for genes affiliated with Retinoblastoma

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25MGI
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MGI Mouse Phenotypes related to retinoblastoma:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1growth/size phenotypeMP:000537826.4PIK3CA, PIK3CG, NCOA6, PDE3B, RECK, RELN
2mortality/agingMP:001076826.3PIK3CA, NDN, NCAM1, NCOA6, RECK, RELN
3cellular phenotypeMP:000538426.0PIK3CA, PIK3CG, NDN, NCAM1, NCOA6, RELN
4nervous system phenotypeMP:000363123.2NDN, NCOA6, RECK, RELN, CNTN1, KIT
5homeostasis/metabolism phenotypeMP:000537623.0PIK3CA, PIK3CG, NDN, NCOA6, PDE3B, KIT
6cardiovascular system phenotypeMP:000538521.8PIK3CA, PIK3CG, NCOA6, RECK, KIT, KITLG
7embryogenesis phenotypeMP:000538020.7PIK3CA, NCOA6, RECK, KIT, SFRP2, RBBP7
8immune system phenotypeMP:000538720.0KIT, RB1CC1, RBL1, NBN, SERPINB2, VIM
9integument phenotypeMP:001077119.2PIK3CG, NDN, NCOA6, PDE3B, RECK, RELN
10tumorigenesisMP:000200618.6PIK3CA, KIT, KITLG, RB1, RBBP8, RBL2
11vision/eye phenotypeMP:000539118.4PIK3CA, NCAM1, NCOA6, RELN, CNTN1, KIT
12reproductive system phenotypeMP:000538918.3PIK3CA, NCOA6, VSX2, SFRP2, RBL2, RBL1
13normal phenotypeMP:000287317.8NDN, KIF4A, SFRP2, RBL2, RB1CC1, RBL1
14hematopoietic system phenotypeMP:000539717.8KIT, PCNA, RB1CC1, RBL1, NBN, SERPINB2
15muscle phenotypeMP:000536917.7PIK3CA, PIK3CG, NDN, NCOA6, RELN, CNTN1
16behavior/neurological phenotypeMP:000538617.3PIK3CA, NDN, NCAM1, RELN, CNTN1, KIT
17skeleton phenotypeMP:000539017.2PIK3CG, RECK, KIT, KITLG, RB1, RBL2
18digestive/alimentary phenotypeMP:000538116.8NCOA6, RELN, KIT, KITLG, RB1, RBL1
19renal/urinary system phenotypeMP:000536715.3KIT, BRCA1, VHL, LMNA, LMO2, MYCN
20no phenotypic analysisMP:000301215.2NDN, VSX2, SFRP2, PCNA, RB1, RBL2
21endocrine/exocrine gland phenotypeMP:000537914.7VSX2, SFRP2, RBL2, RBL1, NBN, BRCA1
22limbs/digits/tail phenotypeMP:000537114.5NCOA6, RECK, KIT, KITLG, SFRP2, RB1
23craniofacial phenotypeMP:000538214.4NCOA6, KIT, KITLG, RBL1, NBN, MYCN
24pigmentation phenotypeMP:000118614.0NCOA6, PDE3B, KIT, KITLG, VSX2, RB1
25adipose tissue phenotypeMP:000537513.8PIK3CA, PDE3B, RB1, RBL1, BRCA1, LMNA
26hearing/vestibular/ear phenotypeMP:000537713.7KIT, KITLG, RB1, VDR, LMNA, MYC
27respiratory system phenotypeMP:000538813.7NDN, BRCA1, MYCN, MYOD1, BID, PARK2
28liver/biliary system phenotypeMP:000537012.8NCOA6, RECK, KIT, RB1CC1, RBL1, VHL

Publications for genes affiliated with Retinoblastoma

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35PubMed
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Articles related to retinoblastoma:

(show top 50)    (show all 1271)
idTitleAuthorsYearAffiliating Genes
1The E2F-1 associated retinoblastoma-susceptibility ge ne product is modified by O-GlcNAc. (20680651)Wells L.... Hart G.W.2011RB1, E2F1
2RNAi mediated acute depletion of retinoblastoma prote in (pRb) promotes aneuploidy in human primary cells via micronuclei formation. (19883508)Amato A.... Di Leonardo A.2009RB1
3Discovery of retinoblastoma-associated binding protei n 46 as a novel prognostic marker for distant metastasis in nonsmall cell lung cancer by combined analysis of cancer cell secretome and pleural effusion prote ome. (19655816)Wang C.L.... Yu C.J.2009CEACAM5, RBBP7
4AMP-activated protein kinase is involved in neural stem cell growth suppression and cell cycle arrest by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside and glucose deprivation by down-regulating phospho-retinoblastoma protein and cyclin D. (19144636)Zang Y.... Li J.2009RB1, ADK, PRKAB1
5Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation. (18071317)Jiao W.... Rane S.G.2008RB1
6Abnormal expression of p16(INK4a), cyclin D1, cyclin-dependent kinase 4 and retinoblastoma protein in gastric carcinomas. (18484097)Kishimoto I.... Watanabe M.2008CDK4, CCND1, CDKN2A
7Folic acid transport via high affinity carrier-mediated system in human retinoblastoma cells. (18207340)Kansara V.... Mitra A.K.2008PTK2B
8Insights from mouse models into human retinoblastoma. (18489754)MacPherson D.2008RB1
9Neurotrophin receptor expression in human primary retinoblastomas and retinoblastoma cell lines. (17973327)Stephan H.... Eggert A.2008NTRK1, NTRK3, TNFRSF1B
10Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. (17456764)Agoston A.T.... Nelson W.G.2007DNMT1, MAD2L1, CDC20
11Retinoblastoma protein prevents staurosporine-induced cell death in a retinoblastoma-defective human glioma cell line. (17496430)Yamasaki F.... Kurisu K.2007CDKN1A, CDKN2A
12Retinoblastoma family proteins as key targets of the small DNA virus oncoproteins. (16936748)Felsani A.... Paggi M.G.2006RBL2, RBL1
13Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma. (15502804)Roesch A.... Vogt T.2005RB1
14Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. (15803180)Roesch A.... Vogt T.2005RB1, KDM5B, KDM5A
15The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. (15485814)Sdek P.... Xiao Z.X.2004MDM2, RB1, E2F1
16Detection of germline mutations in argentine retinoblastoma patients: low and full penetrance retinoblastoma caused by the same germline truncating mutation. (15469703)Dalamon V.... Szijan I.2004RB1
17Recruitment of thyroid hormone receptor/retinoblastoma-interacting protein 230 by the aryl hydrocarbon receptor nuclear translocator is required for the transcriptional response to both dioxin and hypoxia. (15485806)Beischlag T.V.... Hankinson O.2004ARNT, TRIP11
18NF-kappa B-dependent induction of cyclin D1 by retinoblastoma protein (pRB) family proteins and tumor-derived pRB mutants. (12594215)Takebayashi T.... Hatakeyama M.2003RB1, CCND1, NFKB1
19Prognostic significance of Fas expression in retinoblastoma. (14533029)Shanmugam M.P.... Krishnakumar S.2003FAS
20Adenoviral-mediated transfer of p53 or retinoblastoma protein blocks cell proliferation and induces apoptosis in culture-activated h epatic stellate cells. (12547405)Abriss B.... Weiskirchen R.2003TP53
21Loss of heterozygosity and mutations are the major mechanisms of RB1 gene inactivation in Chinese with sporadic retinoblastoma. (12402348)Choy K.W.... Lam D.S.2002RB1
22Retinoblastoma tumor suppressor and genome stability. (12374284)Zheng L.... Lee W.H.2002RB1
23Immunoglobulin superfamily expression in primary retinoblastoma and retinoblastoma cell lines. (12392158)Madigan M.C.... Conway R.M.2002ICAM1, NCAM1, THY1
24Binding of phosphatase-1 delta to the retinoblastoma protein pRb involves domains that include substrate recognition residues and a pRB binding motif. (11162467)Bianchi M.... Villa-Moruzzi E.2001RB1
25Expression of the retinoblastoma-related p107 and Rb2/p130 genes in human placenta: an immunohistochemical study. (11642725)Cavallotti I.... De Luca A.2001RBL2, RBL1
26Clinicopathologic study of retinoblastoma including M IB-1, p53, and CD99 immunohistochemistry. (11436168)Schwimer C.J.... Prayson R.A.2001TP53
27Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. (11408803)Azechi H.... Nakao K.2001RB1
28Endogenous CRX expression and IRBP promoter activity in retinoblastoma cells. (11597600)Boatright J.H.... Nickerson J.M.2001CRAT, CRX, RBP3
29Retinoblastoma protein activation of interleukin 8 expression inhibits tumor cell survival in nude mice. (11149598)Zhang H.... Blanck G.2000IL8
30Association of protein phosphatase-1delta with the retinoblastoma protein and reversible phosphatase activation in mitotic HeLa cells and in cells released from mitosis. (9207224)Puntoni F.... Villa-Moruzzi E.1997PPP1CB, CDKN3
31Formation of the early-region-2 transcription-factor-1-retinoblastoma-protein (E2F-1-RB) transrepressor and release of the retinoblastoma protein from nuclear complexes containing cyclin A is induced by interferon alpha in U937V cells but not in interferon-alpha-resistant U937VR cells. (9219533)Kirch H.C.... Kloke O.1997CCNA2
32Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma. (9309117)Ohtani-Fujita N.... Sakai T.1997RB1
33Early phosphorylation of the retinoblastoma gene product regulates protein binding to the c-fos retinoblastoma control element during T cell activation. (9364216)Felzien L.K.... Benedict S.H.1997FOS
34The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T-antigen in human mesotheliomas. (9256285)De Luca A.... Giordano A.1997RBL1, TAG
35The helix-loop-helix protein Id-1 and a retinoblastoma protein binding mutant of SV40 T antigen synergize to reactivate DNA synthesis in senescent human fibroblasts. (8934878)Hara E.... Campisi J.1996RBL2
36The spectrum of RB1 germ-line mutations in hereditary retinoblastoma. (8651278)Lohmann D.R.... Horsthemke B.1996RB1
37Alterations of retinoblastoma, p53, p16(CDKN2), and p15 genes in human astrocytomas. (8674005)Tsuzuki T.... Nakamura M.1996TP53
38Anomalous retinoblastoma protein expression in Sternberg-Reed cells in Hodgkin's disease: a comparative study with p53 and Ki67 expression. (8855974)Sanchez-Beato M.... Piris M.A.1996RB1
39Electrophoretic determination of aqueous and serum neuron-specific enolase (NSE) in the diagnosis of retinoblastoma (9590868)Wu Z.... Pan S.1996ENO2
40The retinoblastoma gene is involved in malignant progression of astrocytomas. (7979217)Henson J.W.... Louis D.N.1994RB1
41Deletions of chromosome 13q, mutations in Retinoblastoma 1, and retinoblastoma protein state in human hepatocellular carcinoma. (8033150)Zhang X.... Sekiya T.1994RB1
42Effect of sodium butyrate on the expression of retinoblastoma (RB1) and P53 gene and phosphorylation of retinoblastoma protein in human colon tumor cell line HT29. (8220069)Gope R.... Gope M.L.1993TP53
43Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. (8343202)Ewen M.E.... Livingston D.M.1993CCND2
44Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma. (8343223)Choi S.W.... Lee J.O.1993RB1, MYCN
45A TP53 mutation detected in cells established from an osteosarcoma, but not in the retinoblastoma of a patient with bilateral retinoblastoma and multiple primary osteosarcomas. (1336709)Hovig E.... rresen A.L.1992RB1, TP53
46Reintroduction of a normal retinoblastoma gene into retinoblastoma and osteosarcoma cells inhibits the replication associated function of SV40 large T antigen. (2064998)Uzvolgyi E.... Sumegi J.1991TAG
47Intraocular tumor suppression of retinoblastoma gene-reconstituted retinoblastoma cells. (1933901)Madreperla S.A.... Lee W.H.1991RB1
48Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene. (1901652)Kim S.J.... Roberts A.B.1991TGFB1
49Retinoblastoma in transgenic mice. (1689463)Windle J.J.... Mellon P.L.1990RB1
50Molecular mechanism of retinoblastoma gene inactivation in retinoblastoma cell line Y79. (3413073)Lee E.Y.-H.P.... Lee W.-H.1988RB1

Expression for genes affiliated with Retinoblastoma

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Retinoblastoma

Pathways for genes affiliated with Retinoblastoma

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36QIAGEN, 20KEGG, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters
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Pathways related to retinoblastoma according to GeneDecks:

(show top 50)    (show all 356)
idPathwayScoreTop Affiliating Genes
1Pancreatic Adenocarcinoma3614.7KIT, KITLG, RB1, BRCA2, VEGFC, BMP2
2Cell cycle2014.1PCNA, RB1, RBL2, RBL1, MYC, CHEK1
3Chronic myeloid leukemia2014.1PIK3CA, PIK3CG, RB1, MYC, RAF1, BCR
4TGF-beta Signaling Pathways3713.8PIK3CG, MYC, MYOD1, RAF1, RAC1, MTOR
5Estrogen Pathway3613.8KIT, KITLG, BRCA1, VEGFC, BMP2, BMP6
6Cell cycle Regulation of G1/S transition (part 2)1013.2RB1, RBL2, RBL1, JUN, CDK6, CDK2
7Cell cycle_Cell cycle (generic schema)4113.2RB1, RBL2, RBL1, CDK6, CDK2, CDC25B
8Apoptosis and survival_Role of CDK5 in neuronal death and survival4113.1PIK3CA, RAF1, BCL2, BAD, BAX, JUN
9Melanoma2013.0PIK3CA, PIK3CG, RB1, RAF1, BAD, CDK6
10Small cell lung cancer2013.0PIK3CA, PIK3CG, RB1, MYC, RARB, BCL2
11Glucocorticoid Receptor Signaling3613.0BMP2, BMP6, BCL2, UBE2I, BAX, CEBPB
12Non-small cell lung cancer2013.0PIK3CA, PIK3CG, RB1, RAF1, RASSF1, BAD
13GADD45 Pathway3613.0PCNA, BRCA1, CDK6, CDK3, CDKN1A, CDK9
14Development_Thrombopoietin-regulated cell processes4112.9PIK3CA, MYC, RAF1, RAC1, BIRC5, BAD
15Acute myeloid leukemia2012.7PIK3CA, PIK3CG, KIT, MYC, RARA, RAF1
16Signal transduction_AKT signaling4112.7PIK3CA, PCNA, MYC, BAD, BAX, MTOR
1714-3-3 Induced Intracellular Signaling3612.6KITLG, VEGFC, BMP2, RAF1, BAD, JUN
18Paxillin Interactions3612.4KIT, KITLG, VEGFC, BMP2, RAC1, CDC42
19TGF-Beta Pathway3612.4KITLG, VEGFC, BMP2, BMP6, BCL2, BAX
20Development_EGFR signaling pathway4112.4PIK3CA, MYC, RAF1, RAC1, JUN, MMP2
21eNOS Signaling3612.4KIT, KITLG, BMP2, BMP6, FLT4, AREG
22Translation_Non-genomic (rapid) action of Androgen Receptor4112.3PIK3CA, RAF1, MTOR, IRS1, AR, MDM2
23Development_IGF-1 receptor signaling4112.3PIK3CA, MYC, RAF1, BAD, MTOR, IRS1
24Development IGF-RI signaling1012.2PIK3CA, MYC, RAF1, BAD, MTOR, IRS1
25MNAR-PELP1 and Estrogen Receptor Interaction3612.2RB1, JUN, FOS, MAPK1, CCND1, HRAS
26ErbB2-ErbB3 Heterodimers3612.1RAF1, BAD, MAP2K1, ERBB2, RPS6KB1, PDPK1
27p70S6K Signaling3612.1KIT, KITLG, VEGFC, BMP2, BMP6, RAF1
28MAPK Family Pathway3612.0KITLG, VEGFC, BMP2, BMP6, RAF1, RAC1
29Mitochondrial Apoptosis3611.9KIT, KITLG, VEGFC, BMP2, BMP6, BID
30Bladder cancer2011.8RB1, VEGFA, VEGFC, MYC, RAF1, RASSF1
31Rho Family GTPases3611.6KIT, KITLG, VIM, VEGFC, BMP2, BMP6
32Apoptosis and survival_Anti-apoptotic action of membrane-bound ESR14111.6BAD, MAPK9, MAP3K5, MAP2K1, AKT1, CYCS
33Intracellular Calcium Signaling3611.6KIT, KITLG, VEGFC, BMP2, BMP6, FLT1
34Transcription_Receptor-mediated HIF regulation4111.6PIK3CA, VEGFA, RAF1, MTOR, IRS1, ARNT
35Apoptosis and survival Role of CDK5 in neuronal death and survival1011.5BCL2, BAD, CDK5, CDK5R1, CYCS, NTRK1
36ERK5 Signaling3611.4KIT, KITLG, VEGFC, MYC, BMP2, BMP6
37Immune response Oncostatin M signaling via MAPK in human cells1011.4RAF1, RAC1, CEBPB, ATF2, JUN, MMP1
38Activation of PKC through GPCR3611.4PDE3B, KIT, KITLG, VEGFC, BMP2, BMP6
39Signal transduction AKT signaling1011.2IRS1, TRAP1, PPP2CA, PDPK1
40Transcription Receptor-mediated HIF regulation1011.2RAF1, IRS1, ARNT, INS, INSR, MAPK1
41Cell cycle Regulation of G1/S transition (part 1)1011.2BRCA1, FZR1, CDK6, CDKN1A, CDK2, CDKN1B
42Activation of cAMP-Dependent PKA3611.2PDE3B, KITLG, VEGFC, BMP2, RAF1, BAD
43Apoptosis and survival Anti-apoptotic action of membrane-bound ESR11011.1MAPK9, MAP3K5
44PPAR Pathway3611.0KIT, KITLG, VEGFC, BMP2, RAF1, FLT1
45JAK-STAT Pathway3610.9KIT, KITLG, BRCA1, VEGFC, MYC, BMP2
46Apoptotic Pathways in Synovial Fibroblasts3610.8KIT, KITLG, VEGFC, BMP2, BMP6, FLT1
47Chagas disease (American trypanosomiasis)2010.5PIK3CA, PIK3CG, JUN, FOS, IL2, IL6
48Progesterone-mediated oocyte maturation2010.2PIK3CA, PIK3CG, PDE3B, RAF1, FZR1, CDK2
49Development TGF-beta receptor signaling1010.2RAF1, YY1, FZR1, CDKN1A, CDC16, CDC27
50Activation of PKA through GPCR369.7PDE3B, KIT, KITLG, VEGFC, BMP2, BMP6

Compounds for genes affiliated with Retinoblastoma

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Sources:
32Novoseek , 9DrugBank, 18HMDB, 34PharmGKB, 42Tocris Bioscience
See all sources

Compounds related to retinoblastoma according to GeneDecks:

(show top 50)    (show all 458)
idCompoundScoreTop Affiliating Genes
1calcium32 9 18 9 23.0NCL, PDE3B, RECK, RELN, KIT, KITLG
2atp32 19.9PIK3CA, RFC1, NCAM1, NCL, PDE3B, RECK
3paclitaxel32 34 9 9 21.2PIK3CA, PIK3CG, NCL, KIT, KITLG, PCNA
4leucine32 17.6PIK3CA, RECK, KIT, RB1, RBL1, RBP3
5cysteine32 16.5RECK, RCVRN, PCNA, SERPINF1, BRCA1, LPO
6adp32 18 17.4PIK3CA, PIK3CG, RFC1, RECK, KIT, RAF1
7nitric oxide32 9 18 9 18.8NCAM1, PDE3B, KIT, KITLG, RB1, RBP3
8tamoxifen32 34 9 9 18.8PIK3CA, PCNA, VIM, BRCA1, BRCA2, VEGFA
9forskolin32 42 9 9 18.8PDE3B, VIM, VIP, BMP2, BMP6, RARS
10Adenosine triphosphate9 18 9 17.6PIK3CA, PIK3CG, KIT, RARS, RAF1, LIMK2
11resveratrol32 9 18 9 18.5PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA1
12mg 13232 42 15.8PIK3CG, PCNA, BRCA1, VDR, MYC, MYCN
13imatinib32 34 9 9 17.7PIK3CA, PIK3CG, KIT, KITLG, VIP, VEGFA
14flavopiridol32 9 9 16.6PIK3CG, KIT, RB1, RBL1, VEGFA, BID
15bromodeoxyuridine32 14.4PIK3CA, NCAM1, KITLG, PCNA, RB1, VIM
16adpribose32 14.2PIK3CA, PIK3CG, PCNA, RB1, BRCA1, BRCA2
17n acetylcysteine32 13.9PCNA, RAF1, BIRC5, CHEK1, CEBPB, CDKN1A
18calcitriol32 42 9 18 9 17.9KITLG, RB1, VDR, MYC, BMP2, BMP6
19phosphotyrosine32 13.8PIK3CA, PIK3CG, RECK, KIT, BRCA1, RAF1
20nocodazole32 42 9 9 16.7NCL, VIM, BRCA1, RAF1, RAC1, BIRC5
21n-(4-hydroxyphenyl)retinamide32 13.3RB1, VIM, MYC, BMP6, RARG, RARA
22hydroxyurea32 9 9 15.2NCL, KIT, KITLG, PCNA, NBN, BRCA1
23tetracycline32 9 9 15.0RB1, MYCN, BMP2, RAC1, CDK2, CDKN2A
24olomoucine32 42 9 9 16.0PCNA, RB1, BCL2, BAX, CDKN1A, CDK5
25trastuzumab32 34 9 9 15.8PIK3CA, PIK3CG, KIT, VEGFC, RAF1, BIRC5
26polyacrylamide32 12.8NCL, RECK, RB1, BRCA1, BRCA2, BMP2
27dutp32 12.7PCNA, BIRC5, PARP1, BCL2, BAX, MKI67
28depsipeptide32 12.7KITLG, RB1, MYC, RAF1, BCL2, BAX
29hmba32 12.7RB1, MYC, MYCN, BMP6, RARA, CDKN1A
30dihydrotestosterone32 9 18 9 15.7VIM, VIP, VDR, BMP2, BMP6, CDK6
31sulforaphane32 12.6PIK3CG, RB1, PARP1, JUN, CDKN1A, MGMT
32cd 43732 12.6MYC, RARG, RARA, RARS, RARB, BID
33tgf beta132 12.4KITLG, RBL2, RBL1, MYOD1, BMP6, RARA
34isoproterenol32 9 9 14.3PDE3B, VIM, RAF1, KCNH2, CHGA, CDK7
35ribonucleic acid32 12.1KIT, KITLG, SERPINB2, VEGFC, MYC, BMP2
36aphidicolin32 12.0PCNA, RB1, BRCA1, MYC, CHEK1, CDKN1A
37egcg32 12.0PIK3CG, RAF1, CDK6, CDK2, IVL, MAPK8
38polysaccharide32 12.0NCAM1, RECK, KITLG, BMP2, BMP6, LGALS1
39hoechst 3334232 12.0NCL, KITLG, PCNA, BIRC5, PARP1, BCL2
40staurosporin32 11.8PIK3CA, PIK3CG, BCL2, JUN, CDKN3, IL8
41oxaliplatin32 34 9 9 14.8BRCA1, VEGFA, BIRC5, MTHFR, CEACAM5, CDKN1A
42radicicol32 42 9 9 14.7PIK3CG, VEGFA, RAF1, JUN, AR, MAPK10
43sodium arsenite32 11.6MYC, RAF1, JUN, FASLG, MAPK8, MAPK14
44sp 60012532 42 12.5PIK3CG, BID, CDKN1A, MMP1, CASP3, AKT1
45fludarabine32 9 9 13.3BID, BIRC5, PARP1, BCL2, BAG1, BAX
46sodium nitroprusside32 11.3PCNA, VIP, BMP6, S100B, IRS1, FASLG
47neomycin32 11.2KITLG, VIM, BMP2, CEACAM5, CDKN2A, IL2
48pdtc32 11.2PIK3CA, PIK3CG, RAF1, BIRC5, PARP1, BCL2
49ganciclovir32 9 9 13.0KITLG, VIM, BMP6, CDKN3, CD9, FGFR2
50bleomycin32 9 9 12.8BRCA1, BRCA2, MVP, CDKN3, FGF2, CCL2

GO Terms for genes affiliated with Retinoblastoma

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Sources:
12Gene Ontology
See all sources

Cellular components related to retinoblastoma according to GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00563431.4ZNF22, NDC80, NDN, NCL, NCOA6, KIT
2cytoplasmGO:00573722.6PIK3CG, RELN, KIT, KIF4A, KITLG, KIF14
3nucleoplasmGO:00565419.8ZNF473, RFC1, NCOA6, RCC1, PCNA, RB1
4cytosolGO:00582917.8PIK3CA, PIK3CG, NDC80, NDN, PDE3B, KIF4A
5nucleolusGO:00573017.3ZNF22, NCL, NCOA6, KIF4A, VSX2, RCC1
6transcription factor complexGO:00566713.6NCOA6, RBL2, LMO2, MYOD1, RARG, PARP1
7perinuclear region of cytoplasmGO:04847112.5LMNA, PARK2, BCL3, BAG1, S100B, CENPF
8chromatinGO:00078512.4RB1, RBL2, MYCN, CHEK1, L3MBTL1, CENPF
9protein complexGO:04323412.3BRCA1, BRCA2, MYC, BMP2, BCL3, LDB1
10nuclear chromatinGO:00079011.9RCC1, MYOD1, RARA, PAX6, KDM1A, KDM4C
11PML bodyGO:01660511.6RB1, UBE2I, MTOR, CDK9, TRIM27, TP53
12cyclin-dependent protein kinase holoenzyme complexGO:00030711.6CDK6, CDKN1A, CDK2, CDK4, CCNE1, CCND2
13cell surfaceGO:00998610.9NCAM1, VEGFA, BMP2, RARA, LGALS1, CDH1
14extracellular spaceGO:0056159.6RELN, KIT, KITLG, SFRP2, SERPINF1, SERPINB2

Biological processes related to retinoblastoma according to GeneDecks:

(show top 50)    (show all 97)
idNameGO IDScoreTop Affiliating Genes
1transcription, DNA-dependentGO:00635119.0ZNF22, NDN, RFC1, VSX2, RB1, RBBP5
2positive regulation of transcription from RNA polymerase II promoterGO:04594416.5NCOA6, VSX2, SFRP2, RB1, RBL1, BRCA1
3negative regulation of transcription, DNA-dependentGO:04589216.2SFRP2, RB1, RBAK, BRCA1, BRMS1, VDR
4negative regulation of transcription from RNA polymerase II promoterGO:00012214.9RBBP8, VHL, VDR, MYC, BMP2, RARG
5positive regulation of transcription, DNA-dependentGO:04589314.9NCOA6, RB1, BRCA1, BRCA2, VHL, MYC
6gene expressionGO:01046714.7ZNF473, RBL1, VDR, MYC, RARG, RARA
7transcription initiation from RNA polymerase II promoterGO:00636714.0NCOA6, RBL1, VDR, MYC, RARG, RARA
8negative regulation of cell proliferationGO:00828513.9NDN, VSX2, SFRP2, RBBP4, VHL, VDR
9signal transductionGO:00716513.8KIT, KITLG, RCVRN, VEGFC, VDR, RARA
10cell proliferationGO:00828313.8KITLG, PCNA, RBBP7, NBN, SERPINF1, RAF1
11mitotic cell cycleGO:00027813.7NDC80, RFC1, PCNA, RB1, RBL2, RBBP4
12G1/S transition of mitotic cell cycleGO:00008213.7RCC1, PCNA, RB1, BCL2, UBC, CDK6
13response to DNA damage stimulusGO:00697413.5NCOA6, RBBP5, BRCA1, MYC, RASSF1, BCL2
14negative regulation of apoptotic processGO:04306613.4PIK3CG, RB1CC1, VEGFA, MYC, RAF1, KDM1A
15apoptotic processGO:00691513.3NBN, VIM, BRCA1, BRMS1, LMNA, RAF1
16blood coagulationGO:00759613.2PIK3CA, PIK3CG, PDE3B, KIF4A, SERPINB2, BSG
17nerve growth factor receptor signaling pathwayGO:04801113.2PIK3CA, NDN, RAF1, RAC1, UBC, BAD
18transcription from RNA polymerase II promoterGO:00636613.0ZNF473, PAX5, PARP1, PAX3, PAX6, KDM5A
19G1 phase of mitotic cell cycleGO:00008013.0RB1, RBL2, RBL1, UBC, CDK6, CDKN1A
20virus-host interactionGO:01904812.9RB1, RBL1, VIM, KDM4A, UBE2I, UBR4
21transforming growth factor beta receptor signaling pathwayGO:00717912.7RBL1, MYC, PARP1, UBC, JUN, CDK9
22response to drugGO:04249312.7SFRP2, NBN, VEGFC, MYC, BCL2, LGALS1
23cell cycle arrestGO:00705012.7RB1, NBN, MYC, RASSF1, KAT2B, CDK6
24positive regulation of cell proliferationGO:00828412.6KIT, VSX2, SFRP2, NBN, VIP, VEGFA
25negative regulation of cell growthGO:03030812.5SFRP2, RB1, RBBP7, BCL2, CDKN1A, CDKN2C
26epidermal growth factor receptor signaling pathwayGO:00717312.5PIK3CA, RAF1, UBC, BAD, MTOR, CDKN1B
27positive regulation of gene expressionGO:01062812.5CNTN1, KIT, VEGFA, VDR, BMP2, PAX6
28Ras protein signal transductionGO:00726512.5RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
29phosphatidylinositol-mediated signalingGO:04801512.4PIK3CA, NDC80, PCNA, BAD, MTOR, CDKN1B
30positive regulation of protein phosphorylationGO:00193412.4RB1CC1, VEGFA, BMP2, MTOR, FLT4, INSR
31response to estradiol stimulusGO:03235512.3BRCA2, VDR, RARA, BID, MMP9, ASS1
32fibroblast growth factor receptor signaling pathwayGO:00854312.2PIK3CA, RAF1, UBC, BAD, MTOR, CDKN1B
33insulin receptor signaling pathwayGO:00828612.1PIK3CA, PDE3B, RAF1, MTOR, CDK1, IRS1
34positive regulation of apoptotic processGO:04306512.1SFRP2, BMP2, RARG, RARB, BID, BAD
35cell divisionGO:05130112.0NDC80, RCC1, RB1, RBBP8, BIRC5, UBE2I
36induction of apoptosis by intracellular signalsGO:00862911.8MYC, BID, BCL2, BAD, BAX, CDKN1A
37regulation of cyclin-dependent protein kinase activityGO:00007911.6CDKN1A, CDKN2C, CDKN1B, CDK7, CDK5R1, CDKN3
38platelet activationGO:03016811.5PIK3CA, PIK3CG, VEGFA, VEGFC, RAF1, RAC1
39agingGO:00756811.4SERPINF1, VDR, JUN, ASS1, APOD, FAS
40DNA repairGO:00628111.4RFC1, NCOA6, PCNA, RBBP8, NBN, BRCA1
41positive regulation of epithelial cell proliferationGO:05067911.4VEGFC, MYC, BMP6, BAD, FGF1, FGFR2
42positive regulation of cell divisionGO:05178111.3VEGFA, VEGFC, FIGF, FGF1, FGF2, FGF3
43cellular response to hypoxiaGO:07145611.2VHL, VEGFA, LMNA, UBC, BAD, MTOR
44S phase of mitotic cell cycleGO:00008411.1RFC1, PCNA, RB1, UBC, FZR1, CDKN1A
45angiogenesisGO:00152511.0PIK3CA, PIK3CG, NCL, PDE3B, VEGFA, VEGFC
46positive regulation of sequence-specific DNA binding transcription factor activityGO:05109111.0KIT, KDM1A, UBE2I, IL6, AKT1, ESR1
47positive regulation of MAPK cascadeGO:04341010.9KIT, CDH2, FLT1, FLT4, AR, INS
48cell cycle checkpointGO:00007510.7RB1, RBBP8, CHEK1, UBC, CDKN1A, CDK2
49positive regulation of MAP kinase activityGO:04340610.7PIK3CG, KITLG, VEGFA, FLT1, FGFR1, HTR2A
50anti-apoptosisGO:00691610.5PIK3CA, SERPINB2, VHL, BIRC5, BCL2, MUC1

Molecular functions related to retinoblastoma according to GeneDecks:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:00551530.8ZNF473, PIK3CA, PIK3CG, NDC80, RFC1, NCL
2DNA bindingGO:00367718.3ZNF22, ZNF473, NDN, KIF4A, RB1, RBL2
3sequence-specific DNA binding transcription factor activityGO:00370017.8VSX2, RB1, VDR, MYC, MYCN, MYBL2
4ATP bindingGO:00552417.7PIK3CA, PIK3CG, RFC1, KIT, KIF4A, KIF13A
5transcription factor bindingGO:00813415.7RB1, RBL1, NBN, VHL, MYC, MYOD1
6sequence-specific DNA bindingGO:04356514.7VSX2, VDR, MYC, RARG, RARA, RARB
7protein heterodimerization activityGO:04698214.0VEGFA, MYC, MYOD1, BMP2, BMP6, RARA
8protein kinase bindingGO:01990113.7RB1CC1, VIM, PARK2, PAX6, BAD, ATF2
9protein homodimerization activityGO:04280313.6NCOA6, KIT, VEGFA, BMP2, BIRC5, BCL2
10transcription regulatory region DNA bindingGO:04421212.8RBBP5, BRCA1, KDM1A, YY1, CEBPA, JUN
11transcription coactivator activityGO:00371312.7NCOA6, RB1, BRCA1, MYOD1, RARA, YY1
12chromatin bindingGO:00368212.7NCOA6, RCC1, LMO2, KDM1A, KDM5A, LDB1
13enzyme bindingGO:01989912.6NCOA6, BRCA1, VHL, RARA, RAC1, BIRC5
14protein kinase activityGO:00467212.1PIK3CG, RAF1, CDK9, CDK5, CDK2, CDK7
15transcription corepressor activityGO:00371412.1RARA, KDM5B, YY1, LDB1, SAP30, MECP2
16identical protein bindingGO:04280212.0PCNA, VIM, RAF1, RASSF1, BIRC5, BCL2
17protein C-terminus bindingGO:00802212.0NCL, VIM, UBE2I, CENPF, CDK7, CDC20
18steroid hormone receptor activityGO:00370711.6VDR, RARG, RARA, RARB, ESR1, ESR2
19p53 bindingGO:00203911.5KDM1A, MUC1, CDK5, CDKN2A, MDM2, TP53BP1
20protein tyrosine kinase activityGO:00471311.4KIT, BCR, INSR, FGFR1, FGFR2, FGFR3
21double-stranded DNA bindingGO:00369011.4MYC, JUN, MEN1, IFI16, HNRPDL, SP1
22protein phosphatase bindingGO:01990311.0BAD, CDH2, CDKN1B, CDC27, CDH1, FLT4
23growth factor activityGO:00808310.7KITLG, VEGFA, VEGFC, BMP2, BMP6, FIGF

Sources for Retinoblastoma

about this section
2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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