ROP
MCID: RTN012
MIFTS: 40

Retinopathy of Prematurity (ROP) malady

Eye category

Summaries for Retinopathy of Prematurity

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64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Retinopathy of prematurity (ROP) or Terry syndrome, previously known as retrolental fibroplasia (RLF),... more...

MalaCards: Retinopathy of Prematurity, also known as retrolental fibroplasia, is related to norrie disease and blindness. An important gene associated with Retinopathy of Prematurity is FZD4 (frizzled family receptor 4), and among its related pathways are HIF-2-alpha transcription factor network and Signaling by VEGF. The compounds verteporfin and azd 2171 have been mentioned in the context of this disorder. Related mouse phenotypes are vision/eye and skeleton.

Description from OMIM:47 133780

Aliases & Classifications for Retinopathy of Prematurity

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Aliases & Descriptions:

retinopathy of prematurity 8 43 47 10 61
retrolental fibroplasia 8 43
premature retinopathy 8
rop 43


External Ids:

Disease Ontology8 DOID:13025
ICD9CM27 362.21, 362.20
MeSH35 D012178
NCIt40 C34982
ICD1025 H35.1

Related Diseases for Retinopathy of Prematurity

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Retinopathy of Prematurity:



Diseases related to retinopathy of prematurity

Clinical Features for Retinopathy of Prematurity

Sources:
47OMIM
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Clinical features from OMIM:

133780

Drugs & Therapeutics for Retinopathy of Prematurity

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Retinopathy of Prematurity

Anatomical Context for Retinopathy of Prematurity

Animal Models for Retinopathy of Prematurity or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Retinopathy of Prematurity

Genetic Variations for Retinopathy of Prematurity

Expression for genes affiliated with Retinopathy of Prematurity

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinopathy of Prematurity

Search GEO for disease gene expression data for Retinopathy of Prematurity.

Pathways for genes affiliated with Retinopathy of Prematurity

Sources:
38NCBI BioSystems Database, 54Reactome, 52QIAGEN, 30KEGG
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Pathways related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4EPAS1
2
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10.4KDR, VEGFA
3
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10.3IL9, ANGPT2, CCL11
4
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10.3EPAS1, EPO, VEGFA
510.3KDR, IGF1, VEGFA
610.3VEGFA, IGF1, CDKN1C
7
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10.3KDR, EPAS1, VEGFA
810.3VEGFA, ANGPT2, IGF1, EPO
910.3FZD4, VEGFA, IGF1, KDR
10
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10.2SERPINF1, IL9, CXCL10, ANGPT2, CCL11
1110.2VEGFA, ANGPT2, IGF1, EPO, KDR
12
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10.2KDR, IL9, IGF1, FZD4, TUBGCP6
13
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10.2CCL11, ANGPT2, IGF1, CXCL10, IL9, KDR
14
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10.2IL9, CXCL10, IGF1, ANGPT2, CCL11, KDR
15
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10.1CCL11, FZD4, ANGPT2, IGF1, CXCL10, IL9
16
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10.1CCL11, SAG, FZD4, VEGFA, IGF1, CXCL10

Compounds for genes affiliated with Retinopathy of Prematurity

Sources:
45Novoseek, 29IUPHAR, 50PharmGKB, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1verteporfin4510.8SERPINF1, VEGFA
2azd 21714510.7KDR, VEGFA
3triamcinolone acetonide45 2911.7SERPINF1, EPO, VEGFA
4su66684510.7VEGFA, KDR
5ptk7874510.7VEGFA, KDR
6erlotinib45 50 1112.7VEGFA, IGF1, KDR
7topotecan45 1111.7EPO, IGF1, VEGFA
8celecoxib45 60 29 50 11 2415.7VEGFA, ANGPT2, EPO, KDR
9infliximab45 50 1112.7CXCL10, ANGPT2, VEGFA
10progestin4510.7KDR, IGF1, ANGPT2, VEGFA
11pge24510.7CCL11, SAG, VEGFA
12suramin45 29 1112.7VEGFA, IGF1, CXCL10, KDR
13dexamethasone45 50 29 1113.6CCL11, VEGFA, ANGPT2, KDR, SERPINF1
14hydrocortisone45 2 60 1113.6KDR, CXCL10, EPO, IGF1
15tarc4510.6IL9, CXCL10, CCL11
16trastuzumab45 50 1112.6KDR, ANGPT2, VEGFA
17zd64744510.6KDR, VEGFA
18heparin45 29 11 2413.6SERPINF1, VEGFA, CCL11
19octreotide45 60 29 1113.6VEGFA, IGF1, EPO
20matrigel4510.6CCL11, VEGFA, ANGPT2, CXCL10, KDR, SERPINF1
21nandrolone decanoate45 1111.6IGF1, EPO
22allergens4510.6CCL11, CXCL10, IL9
23ly2940024510.6CCL11, VEGFA, ANGPT2, IGF1, EPO, KDR
24genistein45 29 60 2 11 2415.6CCL11, VEGFA, IGF1, CXCL10, IL9, KDR
25cyclosporin a45 29 6012.6CCL11, SAG, ANGPT2, EPO, KDR
26nitric oxide45 11 2412.5CCL11, FZD4, ANGPT2, CXCL10, IL9, KDR
27thymidine45 2411.5CCL11, ANGPT2, IGF1, EPO, CXCL10, IL9
28retinoic acid45 2411.5CCL11, ANGPT2, IGF1, CXCL10, IL9, KDR
29carboplatin45 50 1112.5VEGFA, EPO, KDR
30phosphatidylinositol4510.5CCL11, ANGPT2, IGF1, EPO, CXCL10, KDR
31nandrolone45 2411.5EPO, IGF1
32n acetylcysteine4510.5SERPINF1, KDR, VEGFA, CCL11
33axitinib45 60 1112.4KDR, VEGFA
34vegf4510.4CCL11, VEGFA, ANGPT2, IGF1, EPO, EPAS1
35su54164510.4KDR, VEGFA
36oxygen45 2411.3CCL11, SAG, ANGPT2, EPO, EPAS1, SERPINF1
37thalidomide45 50 60 1113.3VEGFA, EPO, KDR
38tyrosine4510.3SERPINF1, CCL11, SAG, FZD4, VEGFA, ANGPT2
39lenalidomide45 1111.3EPO, VEGFA
40rapamycin4510.0KDR, EPO, IGF1, VEGFA

GO Terms for genes affiliated with Retinopathy of Prematurity

Sources:
16Gene Ontology
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Cellular components related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0DEFB127, VEGFA, ANGPT2, IGF1, EPO, CXCL10
2extracellular spaceGO:0056159.7SERPINF1, CCL11, NDP, VEGFA, ANGPT2, IGF1

Biological processes related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix-cell signalingGO:03542610.7FZD4, NDP
2surfactant homeostasisGO:04312910.7VEGFA, EPAS1, KDR
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.6VEGFA, EPO, EPAS1
4branching morphogenesis of an epithelial tubeGO:04875410.6KDR, IGF1, VEGFA
5retina vasculature morphogenesis in camera-type eyeGO:06129910.6FZD4, NDP
6positive regulation of angiogenesisGO:04576610.6CCL11, VEGFA, ANGPT2, KDR
7negative regulation of angiogenesisGO:01652510.6ANGPT2, CXCL10, SERPINF1
8cell maturationGO:04846910.6KDR, EPAS1, VEGFA
9positive regulation of endothelial cell proliferationGO:00193810.6KDR, VEGFA, CCL11
10positive regulation of positive chemotaxisGO:05092710.6KDR, VEGFA
11vasculogenesisGO:00157010.5FZD4, VEGFA, KDR
12positive regulation of cell proliferationGO:00828410.5KDR, IL9, CXCL10, EPO, IGF1, VEGFA
13positive regulation of focal adhesion assemblyGO:05189410.5VEGFA, KDR
14angiogenesisGO:00152510.5TSPAN12, KDR, NAA15, EPAS1, ANGPT2, VEGFA
15positive regulation of transcription, DNA-dependentGO:04589310.5NAA15, EPO, CDKN1C, IGF1, FZD4, NDP
16cellular response to hypoxiaGO:07145610.5EPAS1, EPO, VEGFA
17negative regulation of cell-substrate adhesionGO:01081210.5FZD4, ANGPT2
18signal transductionGO:00716510.4CCL11, NDP, ANGPT2, IGF1, EPO, EPAS1
19cell migration involved in sprouting angiogenesisGO:00204210.4KDR, VEGFA
20positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4EPO, IGF1
21regulation of cell shapeGO:00836010.2CCL11, VEGFA, KDR
22positive regulation of Ras protein signal transductionGO:04657910.1EPO, IGF1

Molecular functions related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.3IL9, IGF1, VEGFA, NDP

Products for genes affiliated with Retinopathy of Prematurity

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Sources for Retinopathy of Prematurity

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet