ROP
MCID: RTN012
MIFTS: 62

Retinopathy of Prematurity (ROP) malady

Eye diseases category

Summaries for Retinopathy of Prematurity

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Retinopathy of prematurity (ROP) or Terry syndrome, previously known as retrolental fibroplasia (RLF),... more...

MalaCards: Retinopathy of Prematurity, also known as retrolental fibroplasia, is related to retinitis and retinal detachment. An important gene associated with Retinopathy of Prematurity is FZD4 (frizzled family receptor 4), and among its related pathways are HIF-2-alpha transcription factor network and Signaling by VEGF. The compounds verteporfin and azd 2171 have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related mouse phenotypes are vision/eye and skeleton.

Description from OMIM:46 133780

Aliases & Classifications for Retinopathy of Prematurity

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Aliases & Descriptions:

retinopathy of prematurity 8 42 46 10 60
retrolental fibroplasia 8 42
premature retinopathy 8
rop 42


External Ids:

Disease Ontology8 DOID:13025
ICD9CM27 362.21, 362.20
MeSH34 D012178
NCIt39 C34982
ICD1025 H35.1

Related Diseases for Retinopathy of Prematurity

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17GeneCards, 18GeneDecks
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Diseases in the Retinopathy of Prematurity family:

Ndp-Related Retinopathy of Prematurity

Diseases related to Retinopathy of Prematurity via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1retinitis31.3SAG
2retinal detachment30.7SERPINF1, VEGFA, FZD4, NDP
3exudative vitreoretinopathy30.6NDP, FZD4, TSPAN12
4vascular disease30.6KDR, ANGPT2, VEGFA
5retinoblastoma30.5SERPINF1, CDKN1C, SAG
6retinal disease30.5NDP, SAG, VEGFA, ANGPT2, IGF1, KDR
7retinal vascular disease30.3NDP, VEGFA, KDR, SERPINF1
8macular holes30.1SERPINF1, ANGPT2
9hemangioma30.1KDR, ANGPT2, VEGFA
10refractive error10.4
11skin hemangioma10.4
12choroiditis10.4
13bilateral retinoblastoma10.3
14ndp-related retinopathy of prematurity10.3
15cystoid macular edema10.2
16astigmatism10.2
17hyperglycemia10.2
18myopia10.2
19strabismus10.2
20hypertrophic scars10.1
21ischemic retinopathy10.1
22periventricular leukomalacia10.1
23paralytic ileus10.1
24familial retinoblastoma10.1
25cycloplegia10.1
26coloboma10.1
27digeorge syndrome10.1
28chorioamnionitis10.1
29funisitis10.1
30neuronitis10.1
31protein s deficiency10.1
32cortical blindness10.1
33tetralogy of fallot10.1
34vitreous detachment10.1
35patent ductus arteriosus10.1
36cataract10.1
37glaucoma10.1
38laryngitis10.1
39retinoschisis10.1
40thrombocytopenia10.1
41age related macular degeneration10.0VEGFA
42hypertension10.0IGF1
43malaria10.0KDR
44nephrotic syndrome10.0CCL11
45myocardial infarction10.0CCL11
46myeloid leukemia10.0IL9
47tetanus10.0IL9
48severe combined immunodeficiency10.0IL9
49leiomyoma10.0CCL11
50eales disease10.0SAG

Graphical network of the top 20 diseases related to Retinopathy of Prematurity:



Diseases related to retinopathy of prematurity

Clinical Features for Retinopathy of Prematurity

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46OMIM
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Clinical features from OMIM:

133780

Drugs & Therapeutics for Retinopathy of Prematurity

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Retinopathy of Prematurity

Drug clinical trials:

Search ClinicalTrials for Retinopathy of Prematurity

Search NIH Clinical Center for Retinopathy of Prematurity

Search CenterWatch for Retinopathy of Prematurity

Genetic Tests for Retinopathy of Prematurity

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Anatomical Context for Retinopathy of Prematurity

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32MalaCards
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MalaCards organs/tissues related to Retinopathy of Prematurity:

32
Eye, Endothelial, Retina, Brain, Colon, Lung, Breast, Placenta

Animal Models for Retinopathy of Prematurity or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Retinopathy of Prematurity:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539110.2NDP, SAG, FZD4, ANGPT2, EPAS1, SERPINF1
2MP:000539010.2HP1BP3, CDKN1C, IGF1, VEGFA, NDP
3MP:000538510.1TSPAN12, NDP, FZD4, ANGPT2, IGF1, CDKN1C
4MP:000363110.0NDP, SAG, EPAS1, SERPINF1
5MP:00053879.9IGF1, ANGPT2, VEGFA, CCL11, CDKN1C, EPAS1
6MP:00053979.9CCL11, VEGFA, IGF1, CDKN1C, EPO, EPAS1
7MP:00053769.8IGF1, ANGPT2, VEGFA, FZD4, CDKN1C, EPO

Publications for Retinopathy of Prematurity

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50PubMed
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Articles related to Retinopathy of Prematurity:

(show top 50)    (show all 579)
idTitleAuthorsYear
1
Fluorescein angiographic observations of peripheral retinal vessel growth in infants after intravitreal injection of bevacizumab as sole therapy for zone I and posterior zone II retinopathy of prematurity. (24403566)
2014
2
Associations of VEGF/VEGF-receptor and HGF/c-Met promoter polymorphisms with progression/regression of retinopathy of prematurity. (23094709)
2013
3
Structural and functional results of indirect diode laser treatment for retinopathy of prematurity from 1999 to 2003 in Kuwait. (23403936)
2013
4
Screening for retinopathy of prematurity in china: a neonatal units-based prospective study. (24204053)
2013
5
Telemedicine for retinopathy of prematurity. (23872819)
2013
6
Early fresh-frozen plasma transfusion decreases the risk of retinopathy of prematurity. (24117975)
2013
7
Poor postnatal weight gain predicts stage 3+ retinopathy of prematurity in very low birth weight infants. (24217077)
2013
8
Early retinopathy of prematurity findings identified with fluorescein angiography. (23546400)
2013
9
A lower oxygen-saturation target decreases retinopathy of prematurity but increases mortality in premature infants. (24160661)
2013
10
Current and future trends in treatment of severe retinopathy of prematurity. (23719311)
2013
11
EEG, brain maturation, and the development of retinopathy of prematurity. (22630132)
2012
12
The association between serum homocysteine levels and retinopathy of prematurity. (23206475)
2012
13
Evaluation of vascular disease progression in retinopathy of prematurity using static and dynamic retinal images. (22019222)
2012
14
Bevacizumab (avastin) for the treatment of retinopathy of prematurity. (22763251)
2012
15
Continuous mode large spot transpupillary thermotherapy for retinopathy of prematurity. (23202406)
2012
16
Improved clinical assessment of a mouse model of retinopathy of prematurity. (23044930)
2012
17
Retinopathy of prematurity in the Dominican Republic: challenges to screening and prevention. (22773287)
2012
18
Educational paper: Retinopathy of prematurity. (22052209)
2012
19
Neonatal intensive care unit-specific screening criteria for retinopathy of prematurity. (23140768)
2012
20
Retinopathy of prematurity: do we still have a problem?: the Charles L. Schepens lecture. (21825195)
2011
21
Understanding clinically undetected macular changes in early retinopathy of prematurity on spectral domain optical coherence tomography. (21551410)
2011
22
Mediators involved in retinopathy of prematurity and emerging therapeutic targets. (21700404)
2011
23
The utility of non-ophthalmologist examination of eyes at risk for serious retinopathy of prematurity. (22053835)
2011
24
Bevacizumab for retinopathy of prematurity. (21675899)
2011
25
Early experience with intravitreal bevacizumab combined with laser treatment for retinopathy of prematurity. (21731338)
2011
26
Infection, oxygen, and immaturity: interacting risk factors for retinopathy of prematurity. (20733333)
2011
27
The advantages of eye photography for retinopathy of prematurity. (21309990)
2011
28
Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. (21726282)
2011
29
Erythropoietin and retinopathy of prematurity. (21303729)
2011
30
Prevalence of retinopathy of prematurity in Latin America. (22174577)
2011
31
Analysis of risk factors for retinopathy of prematurity. (22553734)
2011
32
Retinopathy of prematurity in the time of bevacizumab: incorporating the BEAT-ROP results into clinical practice. (21724044)
2011
33
Serum fructosamine and retinopathy of prematurity. (21732016)
2011
34
Intraretinal calcium channels and retinal morbidity in experimental retinopathy of prematurity. (21976962)
2011
35
Bilateral retinoblastoma presenting at retinopathy of prematurity screening. (20576664)
2010
36
Computer-assisted measurement of retinal vascular width and tortuosity in retinopathy of prematurity. (20625044)
2010
37
Association between assisted reproductive technology and advanced retinopathy of prematurity. (21179223)
2010
38
Genetic screening of Wnt signaling factors in advanced retinopathy of prematurity. (21151595)
2010
39
Retinopathy of prematurity: Recommendations for screening. (22131866)
2010
40
Retinoschisis detected with handheld spectral-domain optical coherence tomography in neonates with advanced retinopathy of prematurity. (20065217)
2010
41
Endothelial nitric oxide synthase genotypes in the etiology of retinopathy of prematurity in premature infants. (20809776)
2010
42
Risk factors for recurrent fibrovascular proliferation in aggressive posterior retinopathy of prematurity after early vitreous surgery. (20609704)
2010
43
Severe zone III retinopathy of prematurity in an infant with a birth weight of more than 1,500 grams. (21214144)
2010
44
Simultaneous analyses of vitreous levels of 27 cytokines in eyes with retinopathy of prematurity. (19700197)
2009
45
Paradoxical myopic shift following cycloplegia in retinopathy of prematurity patients: a case series. (19918353)
2009
46
Retinopathy of prematurity. (17332988)
2007
47
Retinopathy of prematurity: molecular pathology and therapeutic strategies. (12930159)
2003
48
Retinopathy of prematurity: mutations in the Norrie disease gene and the risk of progression to advanced stages. (11285060)
2001
49
Does cryotherapy affect refractive error? Results from treated versus control eyes in the cryotherapy for retinopathy of prematurity trial. (11158812)
2001
50
Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity. (10875087)
1997

Genetic Variations for Retinopathy of Prematurity

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62UniProtKB/Swiss-Prot
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Genetic disease variations for Retinopathy of Prematurity:

62 (show all 20)
id Symbol AA change Variation ID SNP ID
1FZD4p.Met105ValVAR_038947
2FZD4p.Met157ValVAR_038948
3FZD4p.Pro33SerVAR_063920rs61735304
4FZD4p.Gly36AspVAR_063921
5FZD4p.Glu40GlnVAR_063922
6FZD4p.His69TyrVAR_063923rs80358282
7FZD4p.Met105ThrVAR_063924
8FZD4p.Ile114ThrVAR_063925
9FZD4p.Cys181ArgVAR_063927
10FZD4p.Cys204ArgVAR_063929
11FZD4p.Cys204TyrVAR_063930
12FZD4p.Met223LysVAR_063931
13FZD4p.Ile256ValVAR_063932
14FZD4p.Trp335CysVAR_063933
15FZD4p.Met342ValVAR_063934
16FZD4p.Arg417GlnVAR_063936
17FZD4p.Thr445ProVAR_063937
18FZD4p.Gly488AspVAR_063938
19FZD4p.Ser497PheVAR_063939
20FZD4p.Gly525ArgVAR_063940

Expression for genes affiliated with Retinopathy of Prematurity

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Retinopathy of Prematurity

Search GEO for disease gene expression data for Retinopathy of Prematurity.

Pathways for genes affiliated with Retinopathy of Prematurity

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37NCBI BioSystems Database, 53Reactome, 51QIAGEN, 29KEGG
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Pathways related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.4EPAS1
2
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10.4KDR, VEGFA
3
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10.3IL9, ANGPT2, CCL11
4
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10.3EPAS1, EPO, VEGFA
510.3KDR, IGF1, VEGFA
610.3VEGFA, IGF1, CDKN1C
7
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10.3KDR, EPAS1, VEGFA
810.3VEGFA, ANGPT2, IGF1, EPO
910.3FZD4, VEGFA, IGF1, KDR
10
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10.2SERPINF1, IL9, CXCL10, ANGPT2, CCL11
1110.2VEGFA, ANGPT2, IGF1, EPO, KDR
12
Hide members
10.2KDR, IL9, IGF1, FZD4, TUBGCP6
13
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10.2CCL11, ANGPT2, IGF1, CXCL10, IL9, KDR
14
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10.2IL9, CXCL10, IGF1, ANGPT2, CCL11, KDR
15
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10.1CCL11, FZD4, ANGPT2, IGF1, CXCL10, IL9
16
Hide members
10.1CCL11, SAG, FZD4, VEGFA, IGF1, CXCL10

Compounds for genes affiliated with Retinopathy of Prematurity

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44Novoseek, 28IUPHAR, 49PharmGKB, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 40)
idCompoundScoreTop Affiliating Genes
1verteporfin4410.8SERPINF1, VEGFA
2azd 21714410.7KDR, VEGFA
3triamcinolone acetonide44 2811.7SERPINF1, EPO, VEGFA
4su66684410.7VEGFA, KDR
5ptk7874410.7VEGFA, KDR
6erlotinib44 49 1112.7VEGFA, IGF1, KDR
7topotecan44 1111.7EPO, IGF1, VEGFA
8celecoxib44 59 28 49 11 2415.7VEGFA, ANGPT2, EPO, KDR
9infliximab44 49 1112.7CXCL10, ANGPT2, VEGFA
10progestin4410.7KDR, IGF1, ANGPT2, VEGFA
11pge24410.7CCL11, SAG, VEGFA
12suramin44 28 1112.7VEGFA, IGF1, CXCL10, KDR
13dexamethasone44 49 28 1113.6CCL11, VEGFA, ANGPT2, KDR, SERPINF1
14hydrocortisone44 2 59 1113.6KDR, CXCL10, EPO, IGF1
15tarc4410.6IL9, CXCL10, CCL11
16trastuzumab44 49 1112.6KDR, ANGPT2, VEGFA
17zd64744410.6KDR, VEGFA
18heparin44 28 11 2413.6SERPINF1, VEGFA, CCL11
19octreotide44 59 28 1113.6VEGFA, IGF1, EPO
20matrigel4410.6CCL11, VEGFA, ANGPT2, CXCL10, KDR, SERPINF1
21nandrolone decanoate44 1111.6IGF1, EPO
22allergens4410.6CCL11, CXCL10, IL9
23ly2940024410.6CCL11, VEGFA, ANGPT2, IGF1, EPO, KDR
24genistein44 28 59 2 11 2415.6CCL11, VEGFA, IGF1, CXCL10, IL9, KDR
25cyclosporin a44 28 5912.6CCL11, SAG, ANGPT2, EPO, KDR
26nitric oxide44 11 2412.5CCL11, FZD4, ANGPT2, CXCL10, IL9, KDR
27thymidine44 2411.5CCL11, ANGPT2, IGF1, EPO, CXCL10, IL9
28retinoic acid44 2411.5CCL11, ANGPT2, IGF1, CXCL10, IL9, KDR
29carboplatin44 49 1112.5VEGFA, EPO, KDR
30phosphatidylinositol4410.5CCL11, ANGPT2, IGF1, EPO, CXCL10, KDR
31nandrolone44 2411.5EPO, IGF1
32n acetylcysteine4410.5SERPINF1, KDR, VEGFA, CCL11
33axitinib44 59 1112.4KDR, VEGFA
34vegf4410.4CCL11, VEGFA, ANGPT2, IGF1, EPO, EPAS1
35su54164410.4KDR, VEGFA
36oxygen44 2411.3CCL11, SAG, ANGPT2, EPO, EPAS1, SERPINF1
37thalidomide44 49 59 1113.3VEGFA, EPO, KDR
38tyrosine4410.3SERPINF1, CCL11, SAG, FZD4, VEGFA, ANGPT2
39lenalidomide44 1111.3EPO, VEGFA
40rapamycin4410.0KDR, EPO, IGF1, VEGFA

GO Terms for genes affiliated with Retinopathy of Prematurity

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16Gene Ontology
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Cellular components related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.0DEFB127, VEGFA, ANGPT2, IGF1, EPO, CXCL10
2extracellular spaceGO:0056159.7SERPINF1, CCL11, NDP, VEGFA, ANGPT2, IGF1

Biological processes related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

(show all 22)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix-cell signalingGO:03542610.7FZD4, NDP
2surfactant homeostasisGO:04312910.7VEGFA, EPAS1, KDR
3regulation of transcription from RNA polymerase II promoter in response to hypoxiaGO:06141810.6VEGFA, EPO, EPAS1
4branching morphogenesis of an epithelial tubeGO:04875410.6KDR, IGF1, VEGFA
5retina vasculature morphogenesis in camera-type eyeGO:06129910.6FZD4, NDP
6positive regulation of angiogenesisGO:04576610.6CCL11, VEGFA, ANGPT2, KDR
7negative regulation of angiogenesisGO:01652510.6ANGPT2, CXCL10, SERPINF1
8cell maturationGO:04846910.6KDR, EPAS1, VEGFA
9positive regulation of endothelial cell proliferationGO:00193810.6KDR, VEGFA, CCL11
10positive regulation of positive chemotaxisGO:05092710.6KDR, VEGFA
11vasculogenesisGO:00157010.5FZD4, VEGFA, KDR
12positive regulation of cell proliferationGO:00828410.5KDR, IL9, CXCL10, EPO, IGF1, VEGFA
13positive regulation of focal adhesion assemblyGO:05189410.5VEGFA, KDR
14angiogenesisGO:00152510.5TSPAN12, KDR, NAA15, EPAS1, ANGPT2, VEGFA
15positive regulation of transcription, DNA-dependentGO:04589310.5NAA15, EPO, CDKN1C, IGF1, FZD4, NDP
16cellular response to hypoxiaGO:07145610.5EPAS1, EPO, VEGFA
17negative regulation of cell-substrate adhesionGO:01081210.5FZD4, ANGPT2
18signal transductionGO:00716510.4CCL11, NDP, ANGPT2, IGF1, EPO, EPAS1
19cell migration involved in sprouting angiogenesisGO:00204210.4KDR, VEGFA
20positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4EPO, IGF1
21regulation of cell shapeGO:00836010.2CCL11, VEGFA, KDR
22positive regulation of Ras protein signal transductionGO:04657910.1EPO, IGF1

Molecular functions related to Retinopathy of Prematurity according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00808310.3IL9, IGF1, VEGFA, NDP

Products for genes affiliated with Retinopathy of Prematurity

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Sources for Retinopathy of Prematurity

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet