RS
MCID: RYS001
MIFTS: 50

Reye Syndrome (RS) malady

Neuronal, Bone, Liver categories

Summaries for Reye Syndrome

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
See all sources

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NINDS:44 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards: Reye Syndrome, also known as reye's syndrome, is related to hypoglycemia and sudden infant death syndrome. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are proline biosynthesis II (from arginine) and glutamine degradation I. The drug perphenazine and the compounds delta(1)pyrroline-5-carboxylate and flavin semiquinone have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and brain.

MedlinePlus:34 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:64 Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects to many organs,... more...

Aliases & Classifications for Reye Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 44NINDS, 49Orphanet, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal, Bone, Liver


Aliases & Descriptions:

reye syndrome 8 43 10 45 34 61
reye's syndrome 8 43 44 49
fatty liver with encephalopathy 43
rs 43


External Ids:

Disease Ontology8 DOID:14525
MeSH35 D012202
NCIt40 C34983
ICD9CM27 331.81
MESH via Orphanet36 D012202
ICD10 via Orphanet26 G93.7
SNOMED-CT via Orphanet58 74351001
UMLS via Orphanet62 C0035400
ICD1025 G93.7

Related Diseases for Reye Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 93)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.0HADHA, ETFDH, PC, HMGCL, ACADM
2sudden infant death syndrome30.0HADHA, SLC22A5, ACADM
3n syndrome10.6
4micro syndrome10.3
5chickenpox10.2
6kawasaki disease10.2
7conn's syndrome10.2
8alzheimer's disease10.1
9squamous cell carcinoma10.1
10schizophrenia 410.1
11esophageal squamous cell carcinoma10.1
12acute pancreatitis10.0
13systemic lupus erythematosus10.0
14west syndrome10.0
15biotin deficiency10.0
16juvenile rheumatoid arthritis10.0
17adult syndrome10.0
18arthritis10.0
19char syndrome10.0
20short syndrome10.0
21bod syndrome10.0
22kid syndrome10.0
23star syndrome10.0
24plasma fibronectin deficiency10.0
25pancreatitis, idiopathic10.0
26tuberculosis10.0GLUL
27lactic acidosis10.0PC
28crigler-najjar syndrome10.0OTC
29autoimmune hepatitis10.0GOT1
30hyperlysinemia10.0OTC, PC
31urea cycle disorder10.0ASS1
32orotic aciduria10.0ASS1, OTC
33citrullinemia10.0ASS1, OTC
34carbamoyl phosphate synthetase i deficiency disease10.0ASS1, OTC
35organic acidemia10.0PC
36argininosuccinic aciduria10.0ASS1, OTC
37ornithine carbamoyltransferase deficiency10.0OTC, ASS1
38multiple carboxylase deficiency10.0ACADM, OTC, PC
39medium-chain acyl-coenzyme a dehydrogenase deficiency10.0ACADM, HADHA
40propionic acidemia10.0ASS1, OTC, HMGCL
41euthyroid sick syndrome10.0GOT1L1
42acute intermittent porphyria10.0PC, GLUL
43hyperargininemia10.0ASS1, OTC
44rhyns syndrome10.0HADHA, OTC
45phenylketonuria10.0ACADM, OTC, HADHA
46maple syrup urine disease10.0HADHA, HMGCL, OTC
47homocystinuria10.0HADHA, HMGCL, OTC
48neutral lipid storage disease10.0ETFDH, SLC22A5
49systemic primary carnitine deficiency disease10.0ETFDH, SLC22A5
50hepatitis10.0OTC, GPT

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Clinical Features for Reye Syndrome

Drugs & Therapeutics for Reye Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Reye Syndrome

Drug clinical trials:

Search ClinicalTrials for Reye Syndrome

Search NIH Clinical Center for Reye Syndrome

Search CenterWatch for Reye Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Reye Syndrome

Anatomical Context for Reye Syndrome

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Reye Syndrome:

33
Skin, Liver, Brain, Kidney, Whole blood, B cells, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Reye Syndrome

Sources:
51PubMed
See all sources

Articles related to Reye Syndrome:

(show top 50)    (show all 260)
idTitleAuthorsYear
1
Did the patient have Reye syndrome? (21980824)
2011
2
Reyes's syndrome, encephalopathy, hyperammonemia and acetyl salicylic acid ingestion in a city hospital of Buenos Aires, Argentina. (19149521)
2009
3
Reye syndrome and reye-like syndrome. (18725066)
2008
4
The thalamus and midbrain in Reye syndrome. (16648004)
2006
5
A case of Reye syndrome with rotavirus infection accompanied with high cytokines. (16226809)
2006
6
3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. (9658458)
1998
7
Reye syndrome: an international perspective. (8882577)
1995
8
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. (1846348)
1991
9
Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. (1847937)
1991
10
Adult Reye's syndrome: a review with new evidence for a generalized defect in intramitochondrial enzyme processing. (1944914)
1991
11
A sibling-controlled study of intelligence and academic performance following Reye syndrome. (1936633)
1991
12
A case of ornithine transcarbamylase deficiency with acute and late onset simulating Reye's syndrome in an adult male. (2255172)
1990
13
Effects of drugs and fatty acids related to Reye syndrome on brain water content in rats. (2516690)
1989
14
Lipid storage myopathy associated with recurrent Reye syndrome-like attacks, but with a normal carnitine level. (3389475)
1988
15
Urinary evidence of disturbance of mitochondrial respiratory chain in Reye syndrome. (3598782)
1987
16
Pharmacology of Reye syndrome. (2846166)
1987
17
The differential diagnosis of Reye syndrome: muscle biopsy evaluation. (3445923)
1987
18
Changing epidemiology of Reye syndrome in the United States. (3960627)
1986
19
Reye syndrome and aspirin therapy. (3752019)
1986
20
CT findings in adult Reye syndrome. (3923806)
1985
21
National Reye syndrome surveillance--United States, 1982 and 1983. (6419053)
1984
22
Differentiation of chronic salicylism from Reye syndrome. (6504635)
1984
23
Reye syndrome and salicylates. (7152783)
1982
24
Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. (6961432)
1982
25
Decreased serum carnitine in valproate induced Reye syndrome. (6819143)
1982
26
Reye syndrome awareness program. (7166219)
1982
27
National surveillance for Reye syndrome: a five-year review. (7145544)
1982
28
A cluster of cases of Reye syndrome associated with chickenpox. (7145545)
1982
29
Reye syndrome in Bombay. (7327651)
1981
30
Reye syndrome: pathogenesis of encephalopathy in the initial stage not related to liver damage. (7300243)
1980
31
Reye syndrome outbreak in Michigan--preliminary report for early 1979. (431405)
1979
32
Reye syndrome with renal failure. (480055)
1979
33
Triglyceride and cholesterol concentrations in whole serum and in serum lipoproteins in Reye syndrome. (226924)
1979
34
Physostigmine in Reye syndrome. (426462)
1979
35
Short-chain fatty acids in Reye syndrome. (736536)
1978
36
Pyrrolizidine (Senecio) intoxication mimicking Reye syndrome. (722447)
1978
37
Severe coagulopathy complicating charcoal hemoperfusion in children with Reye syndrome. (722443)
1978
38
Organic acids in Reye's like syndrome: similarities with Jamaican vomiting sickness. (68256)
1977
39
Total blood washout and exchange. A valuable tool in acute hepatic coma and Reye's syndrome. (848687)
1977
40
Methyl bromide intoxication: neurologic features, including simulation of Reye syndrome. (561910)
1977
41
Letter: Post-transfusion viral infections in Reye syndrome. (178849)
1976
42
Letter: Reye syndrome protocol. (1130335)
1975
43
Influenza type B-related encephalopathy. The 1971 outbreak of Reye syndrome in Chicago. (1172750)
1975
44
Short-chain organic acidemia and Reye's syndrome. (1167641)
1975
45
Editorial: The diagnosis of Reye syndrome. (1185385)
1975
46
Reye syndrome. A correlated electron-microscopic, viral, and biochemical observation. (1173398)
1975
47
Clinical staging in Reye syndrome. (4834984)
1974
48
Idiopathic acute pancreatitis in children. Association with a clinical picture resembling Reye syndrome. (4413771)
1974
49
Reye syndrome. An association with type I vaccine-like poliovirus. (4361391)
1974
50
Reye syndrome. 3. The hypoglycemia. (4196605)
1973

Genetic Variations for Reye Syndrome

Expression for genes affiliated with Reye Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1OAT, OTC
2
Hide members
10.0OAT, ASS1
3
Hide members
10.0ACADM, HADHA
4
Hide members
9.9OTC, ASS1, OAT
5
Hide members
9.8ACADM, HMGCL, HADHA
6
Hide members
9.6GOT1, GOT2
7
Hide members
9.5HADHA, HMGCR, HMGCL, ACADM
8
Hide members
9.3PC, GOT2, GOT1
9
Hide members
9.3PC, GOT2, GOT1
109.2GOT1, GOT2, GPT
119.2GOT1, GOT1L1, GOT2
12
Hide members
9.2GOT1, GOT1L1, GOT2
138.8GLUL, GPT, GOT2, GOT1, OAT
148.8GLUL, GPT, ASS1, GOT2, GOT1
15
Hide members
8.8GLUL, OTC, ASS1, GOT2, GOT1, OAT
168.7GOT1, GOT2, ASS1, GPT, PC
178.4GLUL, GPT, OTC, ASS1, GOT2, GOT1
18
Hide members
8.4GLUL, PC, GPT, OTC, ASS1, GOT2
19
Hide members
7.7GPT, HMGCR, HMGCL, OTC, ACADM, ASS1

Compounds for genes affiliated with Reye Syndrome

Sources:
45Novoseek, 50PharmGKB, 24HMDB, 11DrugBank, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Reye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1delta(1)pyrroline-5-carboxylate4510.3OTC, ASS1, OAT
2flavin semiquinone4510.2ETFDH, ACADM
3acetyl-l-carnitine4510.2HADHA, OTC, ACADM
4phenylacetic acid50 45 2412.2ASS1, OTC, PC
5benzocaine45 11 2412.2HBG2, CES1
6ammonium4510.2GLUL, OTC, ASS1
73-methylcrotonyl-coa45 2411.2HADHA, PC, ACADM
8riboflavin45 11 2412.2ETFDH, HBG2, ACADM
9citrulline45 2411.2PC, OTC, ASS1
10putrescine45 29 11 2413.1SLC22A5, OTC, OAT
11sodium benzoate50 211.1OTC, ASS1
12aminooxyacetic acid45 2911.1GPT, GLUL
133-hydroxy-3-methylglutaryl-coa45 2411.1CES1, HMGCL, HMGCR
14policosanol4510.0HMGCR, GPT
15decanoic acid45 29 1112.0ACADM, HADHA
16beta sitosterol4510.0HMGCR, CES1
17ubiquinone4510.0HMGCR, ETFDH, HADHA
18malate459.9GLUL, PC, GPT, OTC
19ezetimibe45 1110.9GPT, HMGCR, CES1
20carbamoyl phosphate459.9GLUL, PC, OTC, ASS1, OAT
21valproate459.9OTC, SLC22A5, GPT
22phosphoenolpyruvate45 1110.9GLUL, PC, OTC, ASS1, OAT
23alpha-ketoglutarate459.9OAT, GPT, PC, GLUL
24glycerol45 11 2411.9GLUL, PC, HBG2, OTC
25ornithine45 2410.9GLUL, PC, OTC, ASS1, OAT
26acetyl-coa45 2410.8ACADM, HMGCL, PC, HADHA
27u18666a459.8CES1, HMGCR
28valproic acid45 50 11 2412.8ACADM, OTC, SLC22A5, GPT
29carnitine459.7HADHA, PC, SLC22A5, OTC, ACADM
30carbon459.7GLUL, PC, HBG2, HMGCR
31L-Aspartic Acid11 2410.7GOT1, GOT2, ASS1
32niacin45 1110.7CES1, SLC22A5, HMGCR, GPT
33acyl-coa459.6HADHA, ETFDH, PC, OTC, ACADM, CES1
34campesterol45 2410.6CES1, HMGCR
35fatty acid459.6HADHA, ETFDH, PC, OTC, ACADM, CES1
36nadh45 11 2411.5HADHA, PC, HBG2, HMGCR, ASS1
37aspartate459.4GLUL, PC, GPT, OTC, ASS1, OAT
38pyruvate459.4HADHA, GLUL, PC, GPT, OTC, ASS1
39Pyridoxal Phosphate119.4GPT, GOT2, GOT1, OAT
40famotidine45 2 11 2412.4OAT, GOT1, GOT2, GPT
41urea45 11 2411.3OAT, CES1, ASS1, OTC, GPT, PC
42glutamine459.3HADHA, GLUL, PC, GPT, OTC, ACADM
43l-glutamic acid29 11 2411.2GLUL, GPT, GOT2, GOT1, OAT
44glucose459.1HADHA, GLUL, PC, GPT, OTC, ACADM
45creatinine459.0HADHA, GLUL, HBG2, GPT, HMGCR, OTC
46alanine459.0HADHA, GLUL, PC, HBG2, GPT, ASS1
47glutamate459.0HADHA, GLUL, PC, GPT, OTC, ACADM
48lactate458.9HADHA, GLUL, PC, HBG2, GPT, HMGCR
49lipid458.7HADHA, GLUL, PC, HBG2, GPT, HMGCR
50arginine458.6GLUL, HBG2, GPT, HMGCR, SLC22A5, OTC

GO Terms for genes affiliated with Reye Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057439.0GOT2, OTC, HMGCL, PC, HADHA
2mitochondrial matrixGO:0057598.6OAT, ETFDH, PC, HMGCL, OTC, ACADM
3mitochondrionGO:0057397.8HADHA, GLUL, PC, DHTKD1, HMGCL, OTC

Biological processes related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:00652610.3OTC, ASS1
2fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.2ACADM, ETFDH
3liver developmentGO:00188910.0ACADM, OTC, HMGCL
4urea cycleGO:00005010.0OTC, ASS1
5aspartate biosynthetic processGO:0065329.8GOT1, GOT2
6glutamate catabolic process to aspartateGO:0195509.8GOT1, GOT2
7glutamate catabolic process to 2-oxoglutarateGO:0195519.8GOT1, GOT2
8aspartate catabolic processGO:0065339.7GOT2, GOT1
9aspartate metabolic processGO:0065319.7GOT2, GOT1
10cellular lipid metabolic processGO:0442559.7ACADM, HMGCL, HMGCR, HADHA
11oxaloacetate metabolic processGO:0061079.6PC, GOT2, GOT1
12glutamate metabolic processGO:0065369.6GOT2, GOT1
132-oxoglutarate metabolic processGO:0061039.6GOT1, GOT2
14gluconeogenesisGO:0060949.3GOT1, GOT2, GPT, PC
15cellular amino acid biosynthetic processGO:0086529.1GLUL, GPT, GOT2, GOT1, OAT
16glucose metabolic processGO:0060069.0GOT1, GOT2, PC
17cellular nitrogen compound metabolic processGO:0346418.7GLUL, GPT, OTC, ASS1, GOT2, GOT1
18small molecule metabolic processGO:0442817.3OAT, HADHA, ETFDH, GLUL, PC, GPT

Molecular functions related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fatty-acyl-CoA bindingGO:00006210.0HMGCL, HADHA
2carboxylic acid bindingGO:0314069.7GOT1, HMGCL
3transaminase activityGO:0084839.7GOT1, GOT1L1
4L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.6GOT1, GOT2
5L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.6GOT2, GOT1
6pyridoxal phosphate bindingGO:0301708.7OAT, GOT1, GOT1L1, GOT2, GPT

Products for genes affiliated with Reye Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Reye Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet