MCID: RYS001
MIFTS: 50

Reye Syndrome

Categories: Rare diseases, Neuronal diseases, Gastrointestinal diseases, Liver diseases, Bone diseases

Aliases & Classifications for Reye Syndrome

MalaCards integrated aliases for Reye Syndrome:

Name: Reye Syndrome 12 49 55 51 40 41 14 69
Reye's Syndrome 12 72 49 50
Fatty Liver with Encephalopathy 49
Rs 49

Classifications:



External Ids:

Disease Ontology 12 DOID:14525
ICD10 32 G93.7 K76.0
ICD9CM 34 331.81
MeSH 41 D012202
NCIt 46 C34983
Orphanet 55 ORPHA3096
MESH via Orphanet 42 D012202
UMLS via Orphanet 70 C0035400
ICD10 via Orphanet 33 G93.7
UMLS 69 C0035400

Summaries for Reye Syndrome

NINDS : 50 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary : Reye Syndrome, also known as reye's syndrome, is related to citrullinemia, classic and severe combined immunodeficiency with sensitivity to ionizing radiation, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Reye Syndrome is HMGCL (3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase), and among its related pathways/superpathways are Metabolism and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). Affiliated tissues include liver, brain and skin, and related phenotypes are growth/size/body region and homeostasis/metabolism

Disease Ontology : 12 A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use.

MedlinePlus : 40 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. It always follows another illness. Although it mostly affects children and teens, anyone can get it. It can develop quickly and without warning. It is most common during flu season. Symptoms include Nausea and vomiting Listlessness Personality change - such as irritability, combativeness or confusion Delirium Convulsions Loss of consciousness If these symptoms occur soon after a viral illness, seek medical attention immediately. Reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. Treatment focuses on preventing brain damage. There is no cure. The cause of Reye syndrome is unknown. Studies have shown that taking aspirin increases the risk of getting it. Because of that, health care professionals now recommend other pain relievers for young patients. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 Reye syndrome is a rapidly progressive encephalopathy. Symptoms may include vomiting, personality... more...

Related Diseases for Reye Syndrome

Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 citrullinemia, classic 29.8 ASS1 OTC
2 severe combined immunodeficiency with sensitivity to ionizing radiation 11.8
3 lymphoma, hodgkin, classic 11.3
4 retinoschisis 1, x-linked, juvenile 11.3
5 chickenpox 11.2
6 myelodysplastic syndrome 11.2
7 roberts syndrome 10.9
8 lymphoma, hodgkin, x-linked pseudoautosomal 10.9
9 richter's syndrome 10.9
10 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.3 ACADM HADHA
11 acyl-coa dehydrogenase, medium-chain, deficiency of 10.3 ACADM HADHA
12 hyperlysinemia, type i 10.2 OTC PC
13 postpartum psychosis 10.2 ASS1 OTC
14 carbamoyl phosphate synthetase i deficiency, hyperammonemia due to 10.2 ASS1 OTC
15 carbonic anhydrase va deficiency, hyperammonemia due to 10.2 ASS1 OTC
16 multiple carboxylase deficiency 10.2 OTC PC
17 argininemia 10.2 ASS1 OTC
18 urea cycle disorder 10.2 ASS1 OTC
19 influenza 10.1
20 ornithine transcarbamylase deficiency, hyperammonemia due to 10.1 ASS1 OTC
21 organic acidemia 10.1 ACADM HMGCL
22 hepatitis 10.1
23 argininosuccinic aciduria 10.1 ASS1 OTC
24 acyl-coa dehydrogenase, very long-chain, deficiency of 10.1 HADHA HMGCL
25 encephalopathy 10.1
26 phenylketonuria 10.1 ACADM HADHA OTC
27 orotic aciduria 10.1 ASS1 OTC
28 hyperornithinemia-hyperammonemia-homocitrullinuria syndrome 10.1 OAT OTC
29 methylmalonic aciduria, cblb type 10.0 HMGCL OTC PC
30 propionic acidemia 10.0 ASS1 HMGCL OTC
31 3-hydroxyacyl-coa dehydrogenase deficiency 10.0 ACADM HADHA
32 mental retardation, x-linked, syndromic, snyder-robinson type 10.0
33 cerebritis 9.9
34 ring chromosome y syndrome 9.9
35 body mass index quantitative trait locus 11 9.8
36 body mass index quantitative trait locus 9 9.8
37 body mass index quantitative trait locus 8 9.8
38 body mass index quantitative trait locus 4 9.8
39 body mass index quantitative trait locus 10 9.8
40 body mass index quantitative trait locus 7 9.8
41 body mass index quantitative trait locus 12 9.8
42 body mass index quantitative trait locus 14 9.8
43 body mass index quantitative trait locus 18 9.8
44 kawasaki disease 9.8
45 connective tissue disease 9.8
46 holocarboxylase synthetase deficiency 9.8 HMGCL PC
47 alzheimer disease 9.8
48 colorectal cancer 9.8
49 ovarian cancer 9.8
50 systemic lupus erythematosus 9.7

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to Reye Syndrome

Symptoms & Phenotypes for Reye Syndrome

UMLS symptoms related to Reye Syndrome:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, headache, back pain

MGI Mouse Phenotypes related to Reye Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.86 PC SCD ASS1 HADHA HMGCL HMGCR
2 homeostasis/metabolism MP:0005376 9.81 ACADM SCD ASS1 CES1 HADHA HMGCL
3 liver/biliary system MP:0005370 9.5 ACADM SCD CES1 HADHA HMGCL HMGCR
4 mortality/aging MP:0010768 9.23 OTC PC ACADM ASS1 HADHA HMGCL

Drugs & Therapeutics for Reye Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intracranial Hypertension and Optic Nerve Sheath Diameter Completed NCT01796015

Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: reye syndrome

Genetic Tests for Reye Syndrome

Anatomical Context for Reye Syndrome

MalaCards organs/tissues related to Reye Syndrome:

38
Liver, Brain, Skin, Bone, Pons, Thalamus, Kidney

Publications for Reye Syndrome

Articles related to Reye Syndrome:

(show top 50) (show all 224)
# Title Authors Year
1
Co-Ingestion of Aspirin and Acetaminophen Promoting Fulminant Liver Failure: A Critical Review of Reye Syndrome in the Current Perspective at the Dawn of the 21(st) Century. ( 28945927 )
2017
2
Impact of fatty acid oxidation disorders in child neurology: from Reye syndrome to Pandora's box. ( 25761966 )
2015
3
Hyponatremic seizures and Reye syndrome. ( 23829993 )
2013
4
Did the patient have Reye syndrome? ( 21980824 )
2011
5
Magnetic resonance imaging findings in Reye syndrome: case report and review of the literature. ( 21633106 )
2011
6
Reye syndrome and liver transplantation. ( 21428204 )
2010
7
Acute encephalopathy of Bacillus cereus mimicking Reye syndrome. ( 19796886 )
2010
8
Reye syndrome and reye-like syndrome. ( 18725066 )
2008
9
Reye syndrome: a case report with review of literature. ( 18552890 )
2008
10
Aspirin and Reye syndrome. ( 17523701 )
2007
11
Aspirin and Reye syndrome: a review of the evidence. ( 17523700 )
2007
12
A case of Reye syndrome with rotavirus infection accompanied with high cytokines. ( 16226809 )
2006
13
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. ( 16254043 )
2006
14
The thalamus and midbrain in Reye syndrome. ( 16648004 )
2006
15
Aspirin, Reye syndrome, Kawasaki disease, and allergies; a reconsideration of the links. ( 15557065 )
2004
16
[Reye syndrome and drug induced encephalopathy]. ( 15152490 )
2003
17
Reye syndrome. ( 12865641 )
2003
18
Reassessing Reye syndrome. ( 14662583 )
2003
19
Rotavirus, hepatitis and Reye syndrome. ( 12354277 )
2002
20
A fatal case of Reye syndrome after varicella and ingestion of aspirin. ( 11436370 )
2001
21
Reye syndrome--insights on causation and prognosis. ( 11668090 )
2001
22
Rotavirus gastroenteritis possibly causing reye syndrome. ( 10852203 )
2000
23
Reye syndrome revisited: a descriptive term covering a group of heterogeneous disorders. ( 11014461 )
2000
24
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome. ( 10479043 )
1999
25
Reye's syndrome and salicylate use, by Karen M. Starko, MD, et al, Pediatrics, 1980;66:859-864; and National patterns of aspirin use and Reye syndrome reporting, United States, 1980 to 1985, by Janet B. Arrowsmith et al, Pediatrics, 1987;79:858-863. ( 9729163 )
1998
26
Single-photon emission CT and MR findings in KlA1ver-Bucy syndrome after Reye syndrome. ( 9090419 )
1997
27
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. ( 8840534 )
1996
28
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine. ( 7473134 )
1995
29
Fructose-1,6-diphosphatase deficiency misdiagnosed as Reye syndrome. ( 8591687 )
1995
30
Reye syndrome: an international perspective. ( 8882577 )
1995
31
Medium-chain acyl-CoA dehydrogenase deficiency is not a cause of previously diagnosed Reye syndrome. ( 7474911 )
1995
32
3-Methylglutaconic aciduria presenting as Reye syndrome in a Chinese boy. ( 8598651 )
1995
33
[A case of clinical Reye syndrome with symmetrical abnormal signal areas in the pons and thalami by MRI]. ( 8280450 )
1994
34
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. ( 8116590 )
1993
35
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. ( 8388687 )
1993
36
Symmetrical thalamic lesions on CT in influenza A virus infection presenting with or without Reye syndrome. ( 7687829 )
1993
37
Reye syndrome. ( 1537363 )
1992
38
Kawasaki disease with Reye syndrome: report of one case. ( 1626454 )
1992
39
Neuropathologic findings in Reye syndrome. ( 2002200 )
1991
40
Reye syndrome or side-effects of anti-emetics? ( 1655459 )
1991
41
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. ( 1846348 )
1991
42
Reye syndrome surveillance, 1989--United States. ( 1889094 )
1991
43
From the Centers for Disease Control. Reye syndrome surveillance--United States, 1989. ( 1992203 )
1991
44
Reye syndrome surveillance--United States, 1989. ( 1899129 )
1991
45
Interrelationships of liver and brain with special reference to Reye syndrome. ( 1749212 )
1991
46
Liver histopathology in clinical Reye syndrome. ( 1892227 )
1991
47
Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. ( 1847937 )
1991
48
A sibling-controlled study of intelligence and academic performance following Reye syndrome. ( 1936633 )
1991
49
Argininosuccinate synthetase deficiency and reye syndrome-like presentation. ( 15815320 )
1990
50
Reye syndrome. ( 2386709 )
1990

Variations for Reye Syndrome

Expression for Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for Reye Syndrome

Pathways related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.49 ACADM ASS1 CES1 HADHA HMGCL HMGCR
2
Show member pathways
12.49 ACADM HADHA HMGCL HMGCR SCD
3
Show member pathways
11.7 ACADM HADHA HMGCL
4
Show member pathways
11.68 ACADM ASS1 HADHA OTC PC
5
Show member pathways
11.51 ACADM HADHA SCD
6
Show member pathways
11.4 ACADM HADHA
7
Show member pathways
11.29 ACADM HADHA
8
Show member pathways
11.24 HADHA SCD
9
Show member pathways
11.13 HADHA HMGCL
10
Show member pathways
11.07 ACADM HADHA
11 11.06 ACADM ASS1 HMGCL OAT OTC PC
12 11.03 ACADM HADHA
13
Show member pathways
10.93 ASS1 OTC
14 10.84 PC SCD
15
Show member pathways
10.81 ASS1 OAT OTC
16 10.76 HMGCR SCD
17
Show member pathways
10.55 ASS1 PC
18
Show member pathways
10.4 ACADM HADHA

GO Terms for Reye Syndrome

Cellular components related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrion GO:0005739 9.5 ACADM ASS1 HADHA HMGCL OAT OTC
2 mitochondrial matrix GO:0005759 9.02 ACADM HMGCL OAT OTC PC

Biological processes related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.81 ACADM HADHA HMGCR SCD
2 metabolic process GO:0008152 9.71 ACADM CES1 HADHA PC
3 fatty acid metabolic process GO:0006631 9.54 ACADM HADHA SCD
4 fatty acid beta-oxidation GO:0006635 9.52 ACADM HADHA
5 cholesterol biosynthetic process GO:0006695 9.49 CES1 HMGCR
6 protein tetramerization GO:0051262 9.48 HMGCL HMGCR
7 response to starvation GO:0042594 9.46 ACADM HMGCL
8 regulation of cholesterol biosynthetic process GO:0045540 9.43 HMGCR SCD
9 urea cycle GO:0000050 9.32 ASS1 OTC
10 arginine biosynthetic process GO:0006526 9.26 ASS1 OTC
11 medium-chain fatty acid metabolic process GO:0051791 9.16 ACADM CES1
12 cellular amino acid biosynthetic process GO:0008652 9.13 ASS1 OAT OTC
13 lipid metabolic process GO:0006629 9.1 ACADM HADHA HMGCL HMGCR PC SCD

Molecular functions related to Reye Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.46 ACADM HADHA HMGCR SCD
2 catalytic activity GO:0003824 9.43 HADHA HMGCL PC
3 amino acid binding GO:0016597 8.96 ASS1 OTC
4 fatty-acyl-CoA binding GO:0000062 8.62 HADHA HMGCL

Sources for Reye Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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