MCID: RYS001
MIFTS: 47

Reye Syndrome malady

Rare diseases, Neuronal diseases, Bone diseases, Liver diseases categories

Summaries for Reye Syndrome

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NINDS:42 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary: Reye Syndrome, also known as reye's syndrome, is related to hypoglycemia and myopathy. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are Valine, leucine and isoleucine degradation and glutamate degradation X. The drug perphenazine and the compounds sodium phenylbutyrate and delta(1)pyrroline-5-carboxylate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and kidney.

MedlinePlus:32 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:63 Reye syndrome or Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects... more...

Aliases & Classifications for Reye Syndrome

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 42NINDS, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT, 27ICD9CM, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Reye Syndrome, Aliases & Descriptions:

Name: Reye Syndrome 9 41 11 43 47 32 60
Reye's Syndrome 9 41 42
 
Fatty Liver with Encephalopathy 41
Rs 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Bone diseases, Liver diseases


External Ids:

Disease Ontology9 DOID:14525
MeSH33 D012202
NCIt38 C34983
ICD9CM27 331.81
Orphanet47 3096
MESH via Orphanet34 D012202
ICD10 via Orphanet26 G93.7
UMLS via Orphanet61 C0035400
ICD1025 G93.7

Related Diseases for Reye Syndrome

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Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 92)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.0HMGCL, PC, ACADM
2myopathy30.0GOT1, GOT2, GLUL
3hepatocellular carcinoma29.6OTC, GLUL, ASS1, GOT2, GOT1
4argininosuccinic aciduria10.5OTC
5hepatitis10.5
6influenza10.5
7urea cycle disorder10.5ASS1
8methylmalonic acidemia10.4HMGCL
9ornithine transcarbamylase deficiency10.4OTC, HMGCL
10citrullinemia10.4OTC, ASS1
11carbamoylphosphate synthetase i deficiency10.4OTC, ASS1
12maple syrup urine disease, type ii10.4HMGCL, OTC
13argininemia10.3OTC, ASS1
14orotic aciduria10.3ASS1, OTC
15phenylketonuria10.3OTC, ACADM
16brain edema10.3GLUL, OTC
17lysinuric protein intolerance10.3OTC, ASS1
18cerebritis10.3
19homocystinuria10.3OTC, HMGCL
20hepatic encephalopathy10.3GLUL, ASS1
21organic acidemia10.3PC
22propionicacidemia10.2ASS1, HMGCL, OTC
23galactosemia10.2GLUL, ACADM
24kawasaki disease10.2
25chickenpox10.2
26connective tissue disease10.2
27hyperlysinemia10.2PC, OTC
28hepatitis a10.2GOT2, GOT1
29exanthem10.1GOT2, GOT1
30gallbladder disease10.1GOT2, GOT1
31schizophrenia10.1
32hiv-110.1
33esophagitis10.1
34chronic granulomatous disease10.1OTC, HBG2
35cholangitis10.1GOT2, GOT1
36porphyria, acute intermittent10.1GLUL, PC
37substance abuse10.1GOT2, GOT1
38bilirubin metabolic disorder10.1GOT1, GOT2
39rheumatoid arthritis10.0
40systemic lupus erythematosus10.0
41mitochondrial dna depletion syndrome 610.0
42plasma fibronectin deficiency10.0
43sudden infant death syndrome10.0
44west syndrome10.0
45arthritis10.0
46liver disease10.0
47acute pancreatitis10.0
48juvenile rheumatoid arthritis10.0
493-methylcrotonyl-coa carboxylase deficiency10.0
50gastroenteritis10.0

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Symptoms for Reye Syndrome

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Drugs & Therapeutics for Reye Syndrome

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Drug clinical trials:

Search ClinicalTrials for Reye Syndrome

Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Reye Syndrome

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Anatomical Context for Reye Syndrome

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MalaCards organs/tissues related to Reye Syndrome:

31
Liver, Brain, Kidney, Bone, Skin, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

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Publications for Reye Syndrome

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Articles related to Reye Syndrome:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Reye syndrome and liver transplantation. (21428204)
2010
2
Reye syndrome: a case report with review of literature. (18552890)
2008
3
Reye syndrome and reye-like syndrome. (18725066)
2008
4
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome. (10479043)
1999
5
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)
1996
6
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. (8116590)
1993
7
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. (8388687)
1993
8
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. (1846348)
1991
9
Argininosuccinate synthetase deficiency and reye syndrome-like presentation. (15815320)
1990
10
Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency presenting as a Reye syndrome-like illness. (2515383)
1989
11
Reye syndrome surveillance--United States, 1987 and 1988. (2496293)
1989
12
Progress in Reye syndrome: epidemiology, biochemical mechanisms and animal models. (2659225)
1989
13
Lipid storage myopathy associated with recurrent Reye syndrome-like attacks, but with a normal carnitine level. (3389475)
1988
14
Urinary evidence of disturbance of mitochondrial respiratory chain in Reye syndrome. (3598782)
1987
15
Reye syndrome: the Indian experience. (3440601)
1987
16
Reye syndrome surveillance--United States, 1986. (3116389)
1987
17
Reye syndrome in connective tissue disease. (3712152)
1986
18
Serum dicarboxylic acids in patients with Reye syndrome. (3746531)
1986
19
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
20
Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models. (3969310)
1985
21
Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. (4022693)
1985
22
Prognosis and diagnosis of Reye syndrome by discriminant analysis. (4043346)
1985
23
Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. (3965406)
1985
24
The National Reye Syndrome Surveillance System, 1983. (6100127)
1984
25
Plasma fibronectin deficiency in Reye syndrome. (6470865)
1984
26
Leads from the MMWR. National Reye syndrome surveillance--United States. (6694302)
1984
27
Reye syndrome and salicylates. (7152783)
1982
28
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia. (7062223)
1982
29
Surgeon General's advisory on the use of salicylates and Reye syndrome. (6810083)
1982
30
Reye syndrome and aspirin use: the role of prodromal illness severity in the assessment of relative risk. (7079054)
1982
31
Reye syndrome: serum-induced alterations in brain mitochondrial function are blocked by fatty-acid-free albumin. (7193315)
1981
32
Epidemiology of Reye syndrome. (7030758)
1981
33
Monitoring and management of increased intracranial pressure in Reye syndrome: results in 29 children. (6773021)
1980
34
Treatment of Reye syndrome--importance of clinical staging. (7425578)
1980
35
Reye syndrome associated with vaccination with live virus vaccines. An exploration of possible etiologic relationships. (759059)
1979
36
Pb encephalopathy mimicking Reye syndrome. (469688)
1979
37
Reye syndrome outbreak in Michigan--preliminary report for early 1979. (431405)
1979
38
Recent developments in etiology and therapy of Reye syndrome. (568533)
1978
39
Short-chain fatty acids in Reye syndrome. (736536)
1978
40
Reye syndrome: light and electron microscopic studies of 7 cases. (754413)
1978
41
EEG correlations with biochemical abnormalities in Reye syndrome. (836179)
1977
42
Reye syndrome and influenza. (66607)
1977
43
Hepatic ATP concentrations and glycolytic enzyme activities in Reye syndrome. (185348)
1976
44
Letter: Post-transfusion viral infections in Reye syndrome. (178849)
1976
45
Letter: Reye syndrome. (937296)
1976
46
Intracranial pressure in Reye syndrome. Monitoring and control. (1172751)
1975
47
The treatment of Reye syndrome. (1185386)
1975
48
Reye syndrome with associated influenza A and B infection. (1174373)
1975
49
Letter: Clinical staging in Reye syndrome. (4440657)
1974
50
Reye syndrome. Light and electron microscopic studies. (4718229)
1973

Variations for Reye Syndrome

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Expression for genes affiliated with Reye Syndrome

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Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

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Pathways related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I36
valine degradation I36
pyruvate fermentation to lactate36
isoleucine degradation I36
9.9HMGCL, ACADM
2
Show member pathways
glutamate biosynthesis II36
arginine biosynthesis IV36
9.8OTC, ASS1
3
Show member pathways
aspartate biosynthesis36
9.4GOT2, GOT1
4
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.4GOT1, GOT2
5
Show member pathways
9.4GOT1, GOT2
68.7GOT1, GOT2, ASS1, GLUL
7
Show member pathways
8.6PC, GOT2, GOT1
8
Show member pathways
glycolysis36
gluconeogenesis36
Glycolysis and Gluconeogenesis36
8.6GOT1, GOT2, PC
9
Show member pathways
malate-aspartate shuttle36
glycogen biosynthesis II (from UDP-D-Glucose)36
8.6PC, GOT2, GOT1
10
Show member pathways
citrulline-nitric oxide cycle36
arginine degradation I (arginase pathway)36
proline degradation36
glutamine degradation I36
proline biosynthesis I36
superpathway of citrulline metabolism36
proline biosynthesis II (from arginine)36
citrulline biosynthesis36
arginine degradation VI (arginase 2 pathway)36
Urea cycle and metabolism of amino groups36
asparagine biosynthesis I36
4-hydroxyproline degradation I36
citrulline degradation36
8.4GOT1, GOT2, ASS1, GLUL, OTC
11
Show member pathways
creatine-phosphate biosynthesis36
glycine degradation (creatine biosynthesis)36
putrescine biosynthesis III36
spermidine biosynthesis I36
tryptophan degradation via kynurenine36
spermine biosynthesis36
urea cycle36
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I36
tyrosine degradation I36
L-carnitine biosynthesis36
methylthiopropionate biosynthesis36
2-oxoglutarate decarboxylation to succinyl-CoA36
S-methyl-5-thioadenosine degradation II36
8.4GOT1, GOT2, ASS1, GLUL, OTC
128.2PC, ASS1, GOT2, GOT1
13
Show member pathways
L-serine degradation36
pentose phosphate pathway (oxidative branch)36
formaldehyde oxidation II (glutathione-dependent)36
7.3OTC, GOT1, GOT2, ASS1, ACADM, PC
14
Show member pathways
6.6GOT1, GOT2, ASS1, CES1, ACADM, PC

Compounds for genes affiliated with Reye Syndrome

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Sources:
49PharmGKB, 43Novoseek, 2BitterDB, 28IUPHAR, 12DrugBank, 24HMDB
See all sources

Compounds related to Reye Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1sodium phenylbutyrate4910.2OTC, ASS1
2delta(1)pyrroline-5-carboxylate4310.2ASS1, OTC
3sodium benzoate49 211.2ASS1, OTC
4carbamate4310.1OTC, CES1
5acetyl-l-carnitine4310.1ACADM, OTC
6l-citrulline28 1211.1OTC, ASS1
7bamhi4310.0OTC, ACADM
8ammonium439.9ASS1, GLUL, OTC
93-Sulfopyruvic acid249.9GOT1, GOT2
103-Sulfinylpyruvic acid249.9GOT1, GOT2
114-Hydroxyphenylpyruvic acid249.8GOT2, GOT1
12Cysteic acid249.8GOT2, GOT1
13benzocaine43 24 1211.8HBG2, CES1
14Phenylpyruvic acid249.8GOT1, GOT2
153-Mercaptopyruvic acid249.8GOT1, GOT2
163-Sulfinoalanine24 1210.7GOT2, GOT1
17L-Tyrosine24 1210.7GOT2, GOT1
18L-Phenylalanine24 1210.6GOT2, GOT1
193-methylcrotonyl-coa43 2410.6PC, ACADM
20hydroxylamine439.5GLUL, HBG2
21L-Aspartic acid24 1210.5GOT1, GOT2, ASS1
22l-glutamic acid28 24 1211.5GLUL, GOT2, GOT1
23phenylacetic acid49 43 2411.4ASS1, PC, OTC
24L-Cysteine24 1210.4GOT2, GOT1
25methylene439.4ACADM, HBG2
26malate439.4PC, GLUL, OTC
27citrulline43 2410.4OTC, PC, ASS1
28carnitine439.4ACADM, PC, OTC
29riboflavin43 24 1211.2ACADM, HBG2
30creatinine439.1HBG2, ASS1, GLUL, OTC
31carbamoyl phosphate439.1OTC, GLUL, PC, ASS1
32acetyl-coa43 2410.1ACADM, PC, HMGCL
33phosphoenolpyruvate43 1210.1ASS1, PC, GLUL, OTC
34ornithine43 2410.1ASS1, PC, GLUL, OTC
35acyl-coa439.1OTC, PC, ACADM, CES1
36pyruvate439.1OTC, GLUL, PC, ASS1
37Oxalacetic acid249.1PC, GOT2, GOT1
38glucose 6-phosphate43 2410.0GLUL, PC, HBG2
39glutamine439.0ACADM, PC, GLUL, OTC
40fatty acid439.0CES1, ACADM, PC, OTC
41arginine438.9HBG2, ASS1, ACADM, GLUL, OTC
42aspartate438.9ASS1, PC, GLUL, OTC
43carbon438.8GLUL, PC, HBG2
44glycerol43 24 1210.8HBG2, PC, GLUL, OTC
45glutamate438.7ASS1, ACADM, PC, GLUL, OTC
46urea43 24 1210.7ASS1, CES1, PC, GLUL, OTC
47glucose438.6OTC, GLUL, PC, ACADM, CES1
48atp43 289.6ASS1, CES1, PC, GLUL, OTC
49lactate438.5OTC, GLUL, PC, ACADM, HBG2
50lipid438.1HBG2, CES1, ACADM, PC, GLUL, OTC

GO Terms for genes affiliated with Reye Syndrome

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Cellular components related to Reye Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1axon terminusGO:00436799.6GLUL, GOT1
2mitochondrial inner membraneGO:00057438.2OTC, HMGCL, PC, GOT2
3mitochondrial matrixGO:00057598.2OTC, HMGCL, PC, ACADM, GOT2
4mitochondrionGO:00057397.3GOT2, DHTKD1, ACADM, PC, HMGCL, GLUL

Biological processes related to Reye Syndrome according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:000652610.0OTC, ASS1
2urea cycleGO:00000509.9OTC, ASS1
3liver developmentGO:00018899.7OTC, HMGCL, ACADM
4glutamate catabolic process to 2-oxoglutarateGO:00195519.7GOT1, GOT2
5glutamate catabolic process to aspartateGO:00195509.7GOT1, GOT2
6aspartate biosynthetic processGO:00065329.7GOT1, GOT2
7aspartate catabolic processGO:00065339.6GOT2, GOT1
8aspartate metabolic processGO:00065319.6GOT1, GOT2
9response to starvationGO:00425949.6HMGCL, ACADM
10glutamate metabolic processGO:00065369.4GOT2, GOT1
11cellular amino acid biosynthetic processGO:00086529.4GLUL, GOT2, GOT1
122-oxoglutarate metabolic processGO:00061039.3GOT1, GOT2
13oxaloacetate metabolic processGO:00061078.9GOT1, GOT2, PC
14gluconeogenesisGO:00060948.8GOT1, GOT2, PC
15cellular nitrogen compound metabolic processGO:00346418.7OTC, GLUL, ASS1, GOT2, GOT1
16glucose metabolic processGO:00060068.7GOT1, GOT2, PC
17carbohydrate metabolic processGO:00059758.6PC, GOT2, GOT1
18small molecule metabolic processGO:00442817.3OTC, GOT1, GOT2, ASS1, ACADM, PC

Molecular functions related to Reye Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1carboxylic acid bindingGO:00314069.6GOT1, HMGCL
2manganese ion bindingGO:00301459.5GLUL, HMGCL
3L-aspartate:2-oxoglutarate aminotransferase activityGO:00040699.5GOT2, GOT1
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:00801309.4GOT2, GOT1
5pyridoxal phosphate bindingGO:00301709.4GOT2, GOT1

Products for genes affiliated with Reye Syndrome

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Sources for Reye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet