RS
MCID: RYS001
MIFTS: 55

Reye Syndrome (RS) malady

Rare diseases, Neuronal diseases, Bone diseases, Liver diseases categories
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Summaries for Reye Syndrome

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NINDS:43 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards based summary: Reye Syndrome, also known as reye's syndrome, is related to hypoglycemia and myopathy. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are Valine, leucine and isoleucine degradation and glutamate degradation X. The drug perphenazine and the compounds sodium phenylbutyrate and sodium benzoate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone.

MedlinePlus:33 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:65 Reye syndrome or Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects... more...

Aliases & Classifications for Reye Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 43NINDS, 39NCIt, 57SNOMED-CT, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Reye Syndrome, Aliases & Descriptions:

Name: Reye Syndrome 8 42 10 44 48 33 62
Reye's Syndrome 8 42 43
 
Fatty Liver with Encephalopathy 42 62
Rs 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Bone diseases, Liver diseases


External Ids:

Disease Ontology8 DOID:14525
NCIt39 C34983
MeSH34 D012202
ICD9CM27 331.81
MESH via Orphanet35 D012202
ICD10 via Orphanet26 G93.7
UMLS via Orphanet63 C0035400
ICD1025 G93.7

Related Diseases for Reye Syndrome

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Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.0HMGCL, ACADM, PC
2myopathy30.0GOT2, GOT1, GLUL
3influenza10.5
4argininosuccinic aciduria10.5OTC
5hepatitis10.5
6urea cycle disorder10.5ASS1
7methylmalonic acidemia10.5HMGCL
8ornithine carbamoyltransferase deficiency10.4HMGCL, OTC
9citrullinemia10.4ASS1, OTC
10maple syrup urine disease10.4OTC, HMGCL
11carbamoyl phosphate synthetase i deficiency disease10.4ASS1, OTC
12hyperargininemia10.3ASS1, OTC
13orotic aciduria10.3ASS1, OTC
14phenylketonuria10.3ACADM, OTC
15brain edema10.3GLUL, OTC
16lysinuric protein intolerance10.3ASS1, OTC
17cerebritis10.3
18homocystinuria10.3OTC, HMGCL
19hepatic encephalopathy10.3GLUL, ASS1
20organic acidemia10.3PC
21propionic acidemia10.2ASS1, HMGCL, OTC
22galactosemia10.2GLUL, ACADM
23kawasaki disease10.2
24chickenpox10.2
25connective tissue disease10.2
26hyperlysinemia10.2OTC, PC
27hepatitis a10.2GOT2, GOT1
28exanthem10.2GOT2, GOT1
29gallbladder disease10.1GOT1, GOT2
30chronic granulomatous disease10.1OTC, HBG2
31cholangitis10.1GOT1, GOT2
32alzheimer's disease10.1
33hiv-110.1
34schizophrenia10.1
35esophagitis10.1
36esophageal squamous cell carcinoma10.1
37acute intermittent porphyria10.1PC, GLUL
38substance abuse10.1GOT1, GOT2
39bilirubin metabolic disorder10.1GOT2, GOT1
40west syndrome10.0
41arthritis10.0
42liver disease10.0
43rheumatoid arthritis10.0
44systemic lupus erythematosus10.0
45acute pancreatitis10.0
46juvenile rheumatoid arthritis10.0
47sudden infant death syndrome10.0
483-methylcrotonyl-coa carboxylase deficiency10.0
49gastroenteritis10.0
50herpes simplex10.0

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Symptoms for Reye Syndrome

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Drugs & Therapeutics for Reye Syndrome

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Drug clinical trials:

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Search NIH Clinical Center for Reye Syndrome

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Reye Syndrome

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Anatomical Context for Reye Syndrome

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MalaCards organs/tissues related to Reye Syndrome:

32
Liver, Brain, Bone, Kidney, Skin, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

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Publications for Reye Syndrome

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Articles related to Reye Syndrome:

(show top 50)    (show all 220)
idTitleAuthorsYear
1
Reye syndrome and liver transplantation. (21428204)
2010
2
Reye syndrome: a case report with review of literature. (18552890)
2008
3
Reye syndrome and reye-like syndrome. (18725066)
2008
4
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome. (10479043)
1999
5
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)
1996
6
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. (8116590)
1993
7
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. (8388687)
1993
8
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. (1846348)
1991
9
Argininosuccinate synthetase deficiency and reye syndrome-like presentation. (15815320)
1990
10
Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency presenting as a Reye syndrome-like illness. (2515383)
1989
11
Reye syndrome surveillance--United States, 1987 and 1988. (2496293)
1989
12
Progress in Reye syndrome: epidemiology, biochemical mechanisms and animal models. (2659225)
1989
13
Lipid storage myopathy associated with recurrent Reye syndrome-like attacks, but with a normal carnitine level. (3389475)
1988
14
Urinary evidence of disturbance of mitochondrial respiratory chain in Reye syndrome. (3598782)
1987
15
Reye syndrome: the Indian experience. (3440601)
1987
16
Reye syndrome surveillance--United States, 1986. (3116389)
1987
17
Reye syndrome in connective tissue disease. (3712152)
1986
18
Serum dicarboxylic acids in patients with Reye syndrome. (3746531)
1986
19
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
20
Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models. (3969310)
1985
21
Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. (4022693)
1985
22
Prognosis and diagnosis of Reye syndrome by discriminant analysis. (4043346)
1985
23
Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. (3965406)
1985
24
The National Reye Syndrome Surveillance System, 1983. (6100127)
1984
25
National Reye syndrome surveillance--United States, 1982 and 1983. (6419053)
1984
26
Plasma fibronectin deficiency in Reye syndrome. (6470865)
1984
27
Leads from the MMWR. National Reye syndrome surveillance--United States. (6694302)
1984
28
Reye syndrome and salicylates. (7152783)
1982
29
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia. (7062223)
1982
30
Surgeon General's advisory on the use of salicylates and Reye syndrome. (6810083)
1982
31
Reye syndrome and aspirin use: the role of prodromal illness severity in the assessment of relative risk. (7079054)
1982
32
Reye syndrome: serum-induced alterations in brain mitochondrial function are blocked by fatty-acid-free albumin. (7193315)
1981
33
Epidemiology of Reye syndrome. (7030758)
1981
34
Monitoring and management of increased intracranial pressure in Reye syndrome: results in 29 children. (6773021)
1980
35
Treatment of Reye syndrome--importance of clinical staging. (7425578)
1980
36
Reye syndrome associated with vaccination with live virus vaccines. An exploration of possible etiologic relationships. (759059)
1979
37
Pb encephalopathy mimicking Reye syndrome. (469688)
1979
38
Reye syndrome outbreak in Michigan--preliminary report for early 1979. (431405)
1979
39
Recent developments in etiology and therapy of Reye syndrome. (568533)
1978
40
Short-chain fatty acids in Reye syndrome. (736536)
1978
41
Reye syndrome: light and electron microscopic studies of 7 cases. (754413)
1978
42
EEG correlations with biochemical abnormalities in Reye syndrome. (836179)
1977
43
Hepatic ATP concentrations and glycolytic enzyme activities in Reye syndrome. (185348)
1976
44
Letter: Post-transfusion viral infections in Reye syndrome. (178849)
1976
45
Letter: Reye syndrome. (937296)
1976
46
Intracranial pressure in Reye syndrome. Monitoring and control. (1172751)
1975
47
The treatment of Reye syndrome. (1185386)
1975
48
Reye syndrome with associated influenza A and B infection. (1174373)
1975
49
Letter: Clinical staging in Reye syndrome. (4440657)
1974
50
Reye syndrome. Light and electron microscopic studies. (4718229)
1973

Variations for Reye Syndrome

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Expression for genes affiliated with Reye Syndrome

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Expression patterns in normal tissues for genes affiliated with Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

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Pathways related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I37
valine degradation I37
pyruvate fermentation to lactate37
isoleucine degradation I37
9.9HMGCL, ACADM
2
Show member pathways
glutamate biosynthesis II37
arginine biosynthesis IV37
9.8OTC, ASS1
3
Show member pathways
aspartate biosynthesis37
9.4GOT2, GOT1
4
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.4GOT1, GOT2
5
Show member pathways
9.4GOT1, GOT2
68.7GOT1, GOT2, ASS1, GLUL
7
Show member pathways
8.6PC, GOT2, GOT1
8
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
8.6GOT1, GOT2, PC
9
Show member pathways
malate-aspartate shuttle37
glycogen biosynthesis II (from UDP-D-Glucose)37
8.6PC, GOT2, GOT1
10
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
8.4GOT1, GOT2, ASS1, GLUL, OTC
11
Show member pathways
creatine-phosphate biosynthesis37
glycine degradation (creatine biosynthesis)37
putrescine biosynthesis III37
spermidine biosynthesis I37
tryptophan degradation via kynurenine37
spermine biosynthesis37
urea cycle37
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I37
tyrosine degradation I37
L-carnitine biosynthesis37
methylthiopropionate biosynthesis37
2-oxoglutarate decarboxylation to succinyl-CoA37
S-methyl-5-thioadenosine degradation II37
8.4GOT1, GOT2, ASS1, GLUL, OTC
128.2PC, ASS1, GOT2, GOT1
13
Show member pathways
L-serine degradation37
pentose phosphate pathway (oxidative branch)37
formaldehyde oxidation II (glutathione-dependent)37
7.3OTC, GOT1, GOT2, ASS1, ACADM, PC
14
Show member pathways
6.6GOT1, GOT2, ASS1, CES1, ACADM, PC

Compounds for genes affiliated with Reye Syndrome

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Sources:
50PharmGKB, 2BitterDB, 44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB
See all sources

Compounds related to Reye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1sodium phenylbutyrate5010.2OTC, ASS1
2sodium benzoate50 211.2ASS1, OTC
3delta(1)pyrroline-5-carboxylate4410.2ASS1, OTC
4carbamate4410.1CES1, OTC
5acetyl-l-carnitine4410.1ACADM, OTC
6l-citrulline28 1111.1OTC, ASS1
7bamhi4410.0ACADM, OTC
8ammonium449.9GLUL, ASS1, OTC
93-Sulfinylpyruvic acid249.9GOT1, GOT2
103-Sulfopyruvic acid249.9GOT2, GOT1
11Cysteic acid249.8GOT1, GOT2
124-Hydroxyphenylpyruvic acid249.8GOT1, GOT2
13benzocaine44 24 1111.8HBG2, CES1
14Phenylpyruvic acid249.8GOT1, GOT2
153-Mercaptopyruvic acid249.8GOT1, GOT2
163-Sulfinoalanine24 1110.7GOT1, GOT2
17L-Tyrosine24 1110.7GOT1, GOT2
18L-Phenylalanine24 1110.6GOT1, GOT2
193-methylcrotonyl-coa44 2410.6ACADM, PC
20hydroxylamine449.5GLUL, HBG2
21L-Aspartic acid24 1110.5GOT1, GOT2, ASS1
22l-glutamic acid28 24 1111.5GOT1, GOT2, GLUL
23phenylacetic acid50 44 2411.4ASS1, PC, OTC
24L-Cysteine24 1110.4GOT2, GOT1
25riboflavin44 24 1111.4ACADM, HBG2
26malate449.4PC, OTC, GLUL
27citrulline44 2410.4ASS1, PC, OTC
28carnitine449.4PC, ACADM, OTC
29methylene449.2HBG2, ACADM
30creatinine449.1OTC, ASS1, HBG2, GLUL
31carbamoyl phosphate449.1ASS1, PC, GLUL, OTC
32acetyl-coa44 2410.1ACADM, PC, HMGCL
33phosphoenolpyruvate44 1110.1GLUL, PC, OTC, ASS1
34ornithine44 2410.1ASS1, PC, OTC, GLUL
35acyl-coa449.1OTC, PC, ACADM, CES1
36pyruvate449.1ASS1, PC, GLUL, OTC
37Oxalacetic acid249.1GOT1, GOT2, PC
38glucose 6-phosphate44 2410.0HBG2, PC, GLUL
39glutamine449.0OTC, ACADM, PC, GLUL
40fatty acid449.0OTC, CES1, ACADM, PC
41arginine448.9OTC, HBG2, ASS1, ACADM, GLUL
42aspartate448.9OTC, GLUL, PC, ASS1
43carbon448.8GLUL, PC, HBG2
44glycerol44 24 1110.8OTC, GLUL, HBG2, PC
45glutamate448.7PC, ASS1, OTC, ACADM, GLUL
46urea44 24 1110.7GLUL, PC, ASS1, OTC, CES1
47glucose448.6GLUL, PC, CES1, ACADM, OTC
48atp44 289.6OTC, PC, CES1, ASS1, GLUL
49lactate448.5HBG2, ACADM, PC, GLUL, OTC
50lipid448.1PC, CES1, GLUL, HBG2, OTC, ACADM

GO Terms for genes affiliated with Reye Syndrome

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Cellular components related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon terminusGO:0436799.6GLUL, GOT1
2mitochondrial inner membraneGO:0057438.2OTC, HMGCL, PC, GOT2
3mitochondrial matrixGO:0057598.2OTC, HMGCL, PC, ACADM, GOT2
4mitochondrionGO:0057397.3GOT2, DHTKD1, ACADM, PC, HMGCL, GLUL

Biological processes related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:00652610.0OTC, ASS1
2urea cycleGO:0000509.9OTC, ASS1
3liver developmentGO:0018899.7OTC, HMGCL, ACADM
4glutamate catabolic process to 2-oxoglutarateGO:0195519.7GOT1, GOT2
5glutamate catabolic process to aspartateGO:0195509.7GOT1, GOT2
6aspartate biosynthetic processGO:0065329.7GOT1, GOT2
7aspartate catabolic processGO:0065339.6GOT2, GOT1
8aspartate metabolic processGO:0065319.6GOT1, GOT2
9response to starvationGO:0425949.6HMGCL, ACADM
10glutamate metabolic processGO:0065369.4GOT2, GOT1
11cellular amino acid biosynthetic processGO:0086529.4GLUL, GOT2, GOT1
122-oxoglutarate metabolic processGO:0061039.3GOT1, GOT2
13oxaloacetate metabolic processGO:0061078.9GOT1, GOT2, PC
14gluconeogenesisGO:0060948.8GOT1, GOT2, PC
15cellular nitrogen compound metabolic processGO:0346418.7OTC, GLUL, ASS1, GOT2, GOT1
16glucose metabolic processGO:0060068.7GOT1, GOT2, PC
17carbohydrate metabolic processGO:0059758.6PC, GOT2, GOT1
18small molecule metabolic processGO:0442817.3OTC, GOT1, GOT2, ASS1, ACADM, PC

Molecular functions related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carboxylic acid bindingGO:0314069.6GOT1, HMGCL
2manganese ion bindingGO:0301459.5GLUL, HMGCL
3L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.5GOT2, GOT1
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.4GOT2, GOT1
5pyridoxal phosphate bindingGO:0301709.4GOT2, GOT1

Products for genes affiliated with Reye Syndrome

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Sources for Reye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet