RS
MCID: RYS001
MIFTS: 54

Reye Syndrome (RS) malady

Neuronal diseases, Bone diseases, Liver diseases categories

Summaries for Reye Syndrome

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards: Reye Syndrome, also known as reye's syndrome, is related to hepatitis and hepatitis a. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are proline biosynthesis II (from arginine) and glutamine degradation I. The drug perphenazine and the compounds delta(1)pyrroline-5-carboxylate and flavin semiquinone have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone.

MedlinePlus:33 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:63 Reye syndrome or Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects... more...

Aliases & Classifications for Reye Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 48Orphanet, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Bone diseases, Liver diseases


Aliases & Descriptions:

reye syndrome 8 42 10 44 33 60
reye's syndrome 8 42 43 48
fatty liver with encephalopathy 42
rs 42


External Ids:

Disease Ontology8 DOID:14525
MeSH34 D012202
NCIt39 C34983
ICD9CM27 331.81
MESH via Orphanet35 D012202
ICD10 via Orphanet26 G93.7
SNOMED-CT via Orphanet57 74351001
UMLS via Orphanet61 C0035400
ICD1025 G93.7

Related Diseases for Reye Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6OTC, GPT
2hepatitis a30.2GOT2, GOT1
3hypoglycemia29.9HADHA, ETFDH, PC, HMGCL, ACADM
4pancreatitis29.9GOT1, GOT2
5sudden infant death syndrome29.9HADHA, SLC22A5, ACADM
6myopathy29.9HADHA, ETFDH, GLUL, GPT, HMGCR, GOT2
7hepatitis c29.8GPT, HMGCR, GOT2, GOT1
8hepatocellular carcinoma29.8GLUL, GPT, OTC, ASS1, GOT2, GOT1
9influenza10.5
10cerebritis10.2
11chickenpox10.1
12kawasaki disease10.1
13connective tissue disease10.1
14alzheimer's disease10.1
15esophagitis10.1
16schizophrenia10.1
17squamous cell carcinoma10.1
18acute pancreatitis10.0
19systemic lupus erythematosus10.0
20west syndrome10.0
21biotin deficiency10.0
22juvenile rheumatoid arthritis10.0
23hepatitis b10.0
24adult syndrome10.0
253-methylcrotonyl-coa carboxylase deficiency10.0
26arthritis10.0
27gastroenteritis10.0
28herpes simplex10.0
29intellectual disability10.0
30liver disease10.0
31lupus erythematosus10.0
32rheumatoid arthritis10.0
33image syndrome10.0
34tuberculosis10.0GLUL
35lactic acidosis10.0PC
36crigler-najjar syndrome10.0OTC
37autoimmune hepatitis10.0GOT1
38hyperlysinemia10.0OTC, PC
39urea cycle disorder10.0ASS1
40orotic aciduria10.0ASS1, OTC
41citrullinemia10.0ASS1, OTC
42carbamoyl phosphate synthetase i deficiency disease10.0ASS1, OTC
43organic acidemia10.0PC
44argininosuccinic aciduria10.0ASS1, OTC
45ornithine carbamoyltransferase deficiency10.0OTC, ASS1
46multiple carboxylase deficiency10.0ACADM, OTC, PC
47medium-chain acyl-coenzyme a dehydrogenase deficiency10.0ACADM, HADHA
48propionic acidemia10.0ASS1, OTC, HMGCL
49euthyroid sick syndrome10.0GOT1L1
50acute intermittent porphyria10.0PC, GLUL

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Clinical Features for Reye Syndrome

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Drugs & Therapeutics for Reye Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Reye Syndrome

Drug clinical trials:

Search ClinicalTrials for Reye Syndrome

Search NIH Clinical Center for Reye Syndrome

Search CenterWatch for Reye Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Reye Syndrome

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Anatomical Context for Reye Syndrome

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32MalaCards
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MalaCards organs/tissues related to Reye Syndrome:

32
Liver, Brain, Bone, Kidney, Skin, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

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Publications for Reye Syndrome

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Sources:
50PubMed
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Articles related to Reye Syndrome:

(show top 50)    (show all 231)
idTitleAuthorsYear
1
Hyponatremic seizures and Reye syndrome. (23829993)
2013
2
Magnetic resonance imaging findings in Reye syndrome: case report and review of the literature. (21633106)
2011
3
Reye syndrome and liver transplantation. (21428204)
2010
4
Reye syndrome: a case report with review of literature. (18552890)
2008
5
Reye syndrome and reye-like syndrome. (18725066)
2008
6
A case of Reye syndrome with rotavirus infection accompanied with high cytokines. (16226809)
2006
7
Reye syndrome. (12865641)
2003
8
Neonatal presentation of ventricular tachycardia and a Reye-like syndrome episode associated with disturbed mitochondrial energy metabolism. (12507404)
2002
9
Reye syndrome--insights on causation and prognosis. (11668090)
2001
10
Rotavirus gastroenteritis possibly causing reye syndrome. (10852203)
2000
11
Medium-chain acyl-CoA dehydrogenase deficiency is not a cause of previously diagnosed Reye syndrome. (7474911)
1995
12
A case of clinical Reye syndrome with symmetrical abnormal signal areas in the pons and thalami by MRI]. (8280450)
1994
13
Interrelationships of liver and brain with special reference to Reye syndrome. (1749212)
1991
14
A sibling-controlled study of intelligence and academic performance following Reye syndrome. (1936633)
1991
15
Argininosuccinate synthetase deficiency and reye syndrome-like presentation. (15815320)
1990
16
Medium-chain acyl CoA dehydrogenase deficiency: electron microscopic differentiation from Reye syndrome. (2279505)
1990
17
Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency presenting as a Reye syndrome-like illness. (2515383)
1989
18
Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome. (3417871)
1988
19
Pharmacology of Reye syndrome. (2846166)
1987
20
Reye syndrome in connective tissue disease. (3712152)
1986
21
Kawasaki syndrome, Reye syndrome, and aspirin. (3960631)
1986
22
Reye syndrome--United States, 1985. (3080658)
1986
23
Serum and urinary carnitine and organic acids in Reye syndrome and Reye-like syndrome. (3766902)
1986
24
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
25
Prognosis and diagnosis of Reye syndrome by discriminant analysis. (4043346)
1985
26
Leads from the MMWR. Reye syndrome--United States, 1984. (3968806)
1985
27
Epidemiologic features of Reye syndrome seen in southwestern Pennsylvania 1970-80. (6881403)
1983
28
Influenza B-associated Reye syndrome: report of a case with isolation of a coxsackie A5 virus from CSF. (6315634)
1983
29
Reye syndrome surveillance, 1981-1982. (6427592)
1983
30
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia. (7062223)
1982
31
Reye syndrome complicated by a generalized herpes simplex type I infection. (7452408)
1981
32
Monitoring and management of increased intracranial pressure in Reye syndrome: results in 29 children. (6773021)
1980
33
Reye syndrome in children less than 1 year old: some epidemiologic observations. Ohio State Department of Health Reye Syndrome Investigation Group. (7360554)
1980
34
Treatment of Reye syndrome. (6987947)
1980
35
Reye syndrome: a predictably curable disease. (7413291)
1980
36
Reye syndrome associated with vaccination with live virus vaccines. An exploration of possible etiologic relationships. (759059)
1979
37
Reye syndrome and renal failure. (480054)
1979
38
Reye syndrome: monoamine metabolites in ventricular fluid. (571546)
1979
39
Physostigmine in Reye syndrome. (426462)
1979
40
Reye syndrome: a metabolic response to an acute mitochondrial insult? (563993)
1978
41
Treatment of elevated intracranial pressure in Reye syndrome. (718141)
1978
42
Severe coagulation abnormalities in Reye syndrome. (894409)
1977
43
Significance of positive spike burst in Reye syndrome. (871261)
1977
44
Reye syndrome: diagnostic and therapeutic considerations. (852261)
1977
45
Letter: Reye syndrome. (937296)
1976
46
Metabolic mechanisms in Reye syndrome. End of a Mystery? (769533)
1976
47
Letter: Reye syndrome protocol. (1130335)
1975
48
Reye syndrome cadaveric kidneys: their use in human transplantation. (4607459)
1974
49
Reye syndrome. An association with type I vaccine-like poliovirus. (4361391)
1974
50
Reye syndrome. 3. The hypoglycemia. (4196605)
1973

Genetic Variations for Reye Syndrome

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Expression for genes affiliated with Reye Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 49PharmGKB
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Pathways related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1OAT, OTC
2
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10.0OAT, ASS1
3
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10.0ACADM, HADHA
4
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9.9OTC, ASS1, OAT
5
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9.8ACADM, HMGCL, HADHA
6
Hide members
9.6GOT1, GOT2
7
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9.5HADHA, HMGCR, HMGCL, ACADM
8
Hide members
9.3PC, GOT2, GOT1
9
Hide members
9.3PC, GOT2, GOT1
109.2GOT1, GOT2, GPT
119.2GOT1, GOT1L1, GOT2
12
Hide members
9.2GOT1, GOT1L1, GOT2
138.8GLUL, GPT, GOT2, GOT1, OAT
148.8GLUL, GPT, ASS1, GOT2, GOT1
15
Hide members
8.8GLUL, OTC, ASS1, GOT2, GOT1, OAT
168.7GOT1, GOT2, ASS1, GPT, PC
178.4GLUL, GPT, OTC, ASS1, GOT2, GOT1
18
Hide members
8.4GLUL, PC, GPT, OTC, ASS1, GOT2
19
Hide members
7.7GPT, HMGCR, HMGCL, OTC, ACADM, ASS1

Compounds for genes affiliated with Reye Syndrome

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Sources:
44Novoseek, 49PharmGKB, 24HMDB, 11DrugBank, 28IUPHAR, 2BitterDB
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Compounds related to Reye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1delta(1)pyrroline-5-carboxylate4410.3OTC, ASS1, OAT
2flavin semiquinone4410.2ETFDH, ACADM
3acetyl-l-carnitine4410.2HADHA, OTC, ACADM
4phenylacetic acid49 44 2412.2ASS1, OTC, PC
5benzocaine44 11 2412.2HBG2, CES1
6ammonium4410.2GLUL, OTC, ASS1
73-methylcrotonyl-coa44 2411.2HADHA, PC, ACADM
8riboflavin44 11 2412.2ETFDH, HBG2, ACADM
9citrulline44 2411.2PC, OTC, ASS1
10putrescine44 28 11 2413.1SLC22A5, OTC, OAT
11sodium benzoate49 211.1OTC, ASS1
12aminooxyacetic acid44 2811.1GPT, GLUL
133-hydroxy-3-methylglutaryl-coa44 2411.1CES1, HMGCL, HMGCR
14policosanol4410.0HMGCR, GPT
15decanoic acid44 28 1112.0ACADM, HADHA
16beta sitosterol4410.0HMGCR, CES1
17ubiquinone4410.0HMGCR, ETFDH, HADHA
18malate449.9GLUL, PC, GPT, OTC
19ezetimibe44 1110.9GPT, HMGCR, CES1
20carbamoyl phosphate449.9GLUL, PC, OTC, ASS1, OAT
21valproate449.9OTC, SLC22A5, GPT
22phosphoenolpyruvate44 1110.9GLUL, PC, OTC, ASS1, OAT
23alpha-ketoglutarate449.9OAT, GPT, PC, GLUL
24glycerol44 11 2411.9GLUL, PC, HBG2, OTC
25ornithine44 2410.9GLUL, PC, OTC, ASS1, OAT
26acetyl-coa44 2410.8ACADM, HMGCL, PC, HADHA
27u18666a449.8CES1, HMGCR
28valproic acid44 49 11 2412.8ACADM, OTC, SLC22A5, GPT
29carnitine449.7HADHA, PC, SLC22A5, OTC, ACADM
30carbon449.7GLUL, PC, HBG2, HMGCR
31L-Aspartic Acid11 2410.7GOT1, GOT2, ASS1
32niacin44 1110.7CES1, SLC22A5, HMGCR, GPT
33acyl-coa449.6HADHA, ETFDH, PC, OTC, ACADM, CES1
34campesterol44 2410.6CES1, HMGCR
35fatty acid449.6HADHA, ETFDH, PC, OTC, ACADM, CES1
36nadh44 11 2411.5HADHA, PC, HBG2, HMGCR, ASS1
37aspartate449.4GLUL, PC, GPT, OTC, ASS1, OAT
38pyruvate449.4HADHA, GLUL, PC, GPT, OTC, ASS1
39Pyridoxal Phosphate119.4GPT, GOT2, GOT1, OAT
40famotidine44 2 11 2412.4OAT, GOT1, GOT2, GPT
41urea44 11 2411.3OAT, CES1, ASS1, OTC, GPT, PC
42glutamine449.3HADHA, GLUL, PC, GPT, OTC, ACADM
43l-glutamic acid28 11 2411.2GLUL, GPT, GOT2, GOT1, OAT
44glucose449.1HADHA, GLUL, PC, GPT, OTC, ACADM
45creatinine449.0HADHA, GLUL, HBG2, GPT, HMGCR, OTC
46alanine449.0HADHA, GLUL, PC, HBG2, GPT, ASS1
47glutamate449.0HADHA, GLUL, PC, GPT, OTC, ACADM
48lactate448.9HADHA, GLUL, PC, HBG2, GPT, HMGCR
49lipid448.7HADHA, GLUL, PC, HBG2, GPT, HMGCR
50arginine448.6GLUL, HBG2, GPT, HMGCR, SLC22A5, OTC

GO Terms for genes affiliated with Reye Syndrome

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16Gene Ontology
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Cellular components related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057439.0GOT2, OTC, HMGCL, PC, HADHA
2mitochondrial matrixGO:0057598.6OAT, ETFDH, PC, HMGCL, OTC, ACADM
3mitochondrionGO:0057397.8HADHA, GLUL, PC, DHTKD1, HMGCL, OTC

Biological processes related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:00652610.3OTC, ASS1
2fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.2ACADM, ETFDH
3liver developmentGO:00188910.0ACADM, OTC, HMGCL
4urea cycleGO:00005010.0OTC, ASS1
5aspartate biosynthetic processGO:0065329.8GOT1, GOT2
6glutamate catabolic process to aspartateGO:0195509.8GOT1, GOT2
7glutamate catabolic process to 2-oxoglutarateGO:0195519.8GOT1, GOT2
8aspartate catabolic processGO:0065339.7GOT2, GOT1
9aspartate metabolic processGO:0065319.7GOT2, GOT1
10cellular lipid metabolic processGO:0442559.7ACADM, HMGCL, HMGCR, HADHA
11oxaloacetate metabolic processGO:0061079.6PC, GOT2, GOT1
12glutamate metabolic processGO:0065369.6GOT2, GOT1
132-oxoglutarate metabolic processGO:0061039.6GOT1, GOT2
14gluconeogenesisGO:0060949.3GOT1, GOT2, GPT, PC
15cellular amino acid biosynthetic processGO:0086529.1GLUL, GPT, GOT2, GOT1, OAT
16glucose metabolic processGO:0060069.0GOT1, GOT2, PC
17cellular nitrogen compound metabolic processGO:0346418.7GLUL, GPT, OTC, ASS1, GOT2, GOT1
18small molecule metabolic processGO:0442817.3OAT, HADHA, ETFDH, GLUL, PC, GPT

Molecular functions related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fatty-acyl-CoA bindingGO:00006210.0HMGCL, HADHA
2carboxylic acid bindingGO:0314069.7GOT1, HMGCL
3transaminase activityGO:0084839.7GOT1, GOT1L1
4L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.6GOT1, GOT2
5L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.6GOT2, GOT1
6pyridoxal phosphate bindingGO:0301708.7OAT, GOT1, GOT1L1, GOT2, GPT

Products for genes affiliated with Reye Syndrome

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Sources for Reye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet