RS
MCID: RYS001
MIFTS: 54

Reye Syndrome (RS) malady

Neuronal diseases, Bone diseases, Liver diseases categories

Summaries for Reye Syndrome

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33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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NINDS:43 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards: Reye Syndrome, also known as reye's syndrome, is related to hepatitis and hepatitis a. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are proline biosynthesis II (from arginine) and glutamine degradation I. The drug perphenazine and the compounds delta(1)pyrroline-5-carboxylate and flavin semiquinone have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone.

MedlinePlus:33 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:63 Reye syndrome or Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects... more...

Aliases & Classifications for Reye Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 48Orphanet, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases, Bone diseases, Liver diseases


Aliases & Descriptions:

reye syndrome 8 42 10 44 33 60
reye's syndrome 8 42 43 48
fatty liver with encephalopathy 42
rs 42


External Ids:

Disease Ontology8 DOID:14525
MeSH34 D012202
NCIt39 C34983
ICD9CM27 331.81
MESH via Orphanet35 D012202
ICD10 via Orphanet26 G93.7
SNOMED-CT via Orphanet57 74351001
UMLS via Orphanet61 C0035400
ICD1025 G93.7

Related Diseases for Reye Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis30.6OTC, GPT
2hepatitis a30.2GOT2, GOT1
3hypoglycemia29.9HADHA, ETFDH, PC, HMGCL, ACADM
4pancreatitis29.9GOT1, GOT2
5sudden infant death syndrome29.9HADHA, SLC22A5, ACADM
6myopathy29.9HADHA, ETFDH, GLUL, GPT, HMGCR, GOT2
7hepatitis c29.8GPT, HMGCR, GOT2, GOT1
8hepatocellular carcinoma29.8GLUL, GPT, OTC, ASS1, GOT2, GOT1
9influenza10.5
10cerebritis10.2
11chickenpox10.1
12kawasaki disease10.1
13connective tissue disease10.1
14alzheimer's disease10.1
15esophagitis10.1
16schizophrenia10.1
17squamous cell carcinoma10.1
18acute pancreatitis10.0
19systemic lupus erythematosus10.0
20west syndrome10.0
21biotin deficiency10.0
22juvenile rheumatoid arthritis10.0
23hepatitis b10.0
24adult syndrome10.0
253-methylcrotonyl-coa carboxylase deficiency10.0
26arthritis10.0
27gastroenteritis10.0
28herpes simplex10.0
29intellectual disability10.0
30liver disease10.0
31lupus erythematosus10.0
32rheumatoid arthritis10.0
33image syndrome10.0
34tuberculosis10.0GLUL
35lactic acidosis10.0PC
36crigler-najjar syndrome10.0OTC
37autoimmune hepatitis10.0GOT1
38hyperlysinemia10.0OTC, PC
39urea cycle disorder10.0ASS1
40orotic aciduria10.0ASS1, OTC
41citrullinemia10.0ASS1, OTC
42carbamoyl phosphate synthetase i deficiency disease10.0ASS1, OTC
43organic acidemia10.0PC
44argininosuccinic aciduria10.0ASS1, OTC
45ornithine carbamoyltransferase deficiency10.0OTC, ASS1
46multiple carboxylase deficiency10.0ACADM, OTC, PC
47medium-chain acyl-coenzyme a dehydrogenase deficiency10.0ACADM, HADHA
48propionic acidemia10.0ASS1, OTC, HMGCL
49euthyroid sick syndrome10.0GOT1L1
50acute intermittent porphyria10.0PC, GLUL

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Clinical Features for Reye Syndrome

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Drugs & Therapeutics for Reye Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Reye Syndrome

Drug clinical trials:

Search ClinicalTrials for Reye Syndrome

Search NIH Clinical Center for Reye Syndrome

Search CenterWatch for Reye Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Reye Syndrome

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Anatomical Context for Reye Syndrome

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32MalaCards
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MalaCards organs/tissues related to Reye Syndrome:

32
Liver, Brain, Bone, Kidney, Skin, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

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Publications for Reye Syndrome

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Sources:
50PubMed
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Articles related to Reye Syndrome:

(show top 50)    (show all 231)
idTitleAuthorsYear
1
Acute encephalopathy of Bacillus cereus mimicking Reye syndrome. (19796886)
2010
2
Aspirin and Reye syndrome. (17523701)
2007
3
The thalamus and midbrain in Reye syndrome. (16648004)
2006
4
Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. (16254043)
2006
5
Primary systemic carnitine deficiency presenting as recurrent Reye-like syndrome and dilated cardiomyopathy. (12635840)
2002
6
3-hydroxy-3-methylglutaric aciduria and recurrent Reye-like syndrome]. (9658458)
1998
7
Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine. (7473134)
1995
8
Fructose-1,6-diphosphatase deficiency misdiagnosed as Reye syndrome. (8591687)
1995
9
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. (8116590)
1993
10
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. (8388687)
1993
11
Symmetrical thalamic lesions on CT in influenza A virus infection presenting with or without Reye syndrome. (7687829)
1993
12
Neuropathologic findings in Reye syndrome. (2002200)
1991
13
Reye syndrome or side-effects of anti-emetics? (1655459)
1991
14
Reye syndrome: rate of oxidation of fatty acids in leukocytes and serum levels of lipid peroxides. (2769452)
1989
15
Reye syndrome: the Indian experience. (3440601)
1987
16
Reye syndrome surveillance--United States, 1986. (3116389)
1987
17
The differential diagnosis of Reye syndrome: muscle biopsy evaluation. (3445923)
1987
18
Familial Reye-like syndrome: a presentation of medium-chain acyl-coenzyme A dehydrogenase deficiency. (3822638)
1987
19
Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. (4022693)
1985
20
Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. (3965406)
1985
21
CT findings in adult Reye syndrome. (3923806)
1985
22
National Reye syndrome surveillance, 1982. (3969325)
1985
23
Aspirin and Reye syndrome: a saga unfolds. (3001540)
1985
24
Update: Reye syndrome pilot study--United States, 1984. (3918255)
1985
25
Absence of diffusible inhibitor of glutamate dehydrogenase in the hepatocytes of Reye syndrome patients. (3969301)
1985
26
The National Reye Syndrome Surveillance System, 1983. (6100127)
1984
27
Leads from the MMWR. National Reye syndrome surveillance--United States. (6694302)
1984
28
Development of encephalopathic features similar to Reye syndrome in rabbits. (6592608)
1984
29
Somatic evoked potential evaluation of cerebral status in Reye syndrome. (6187531)
1983
30
Reye syndrome and salicylates. (7152783)
1982
31
Reye syndrome and aspirin use: the role of prodromal illness severity in the assessment of relative risk. (7079054)
1982
32
Interactions of aspirin and other potential etiologic factors in an animal model of Reye syndrome. (6961432)
1982
33
Decreased serum carnitine in valproate induced Reye syndrome. (6819143)
1982
34
Reye syndrome awareness program. (7166219)
1982
35
Neuropathology, pathogenesis, and neuropsychiatric sequelae of Reye syndrome. (7057216)
1982
36
The prognostic significance of peak ammonia levels in Reye syndrome. (7145558)
1982
37
Amino acid pattern in Reye syndrome: comparison with clinically similar entities. (7229762)
1981
38
Reye syndrome: pathogenesis of encephalopathy in the initial stage not related to liver damage. (7300243)
1980
39
An epidemic of Reye syndrome associated with influenza A (H1N1) in Colorado. (7420216)
1980
40
Unsuccessful physostigmine therapy in Reye syndrome. (496413)
1979
41
Acute renal failure in Reye syndrome. (758427)
1979
42
Reye syndrome: computed tomographic documentation of disordered intracerebral structure. (311793)
1979
43
Recent developments in etiology and therapy of Reye syndrome. (568533)
1978
44
Metabolic response to hypertonic glucose administration in Reye syndrome. (666261)
1978
45
Severe coagulopathy complicating charcoal hemoperfusion in children with Reye syndrome. (722443)
1978
46
Intracranial pressure in Reye syndrome. Monitoring and control. (1172751)
1975
47
Reye syndrome with associated influenza A and B infection. (1174373)
1975
48
Editorial: The diagnosis of Reye syndrome. (1185385)
1975
49
Epidemiologic investigation of Reye syndrome. (168340)
1975
50
Acute liver disease and encephalopathy mimicking Reye syndrome. A report of three cases. (1185387)
1975

Genetic Variations for Reye Syndrome

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Expression for genes affiliated with Reye Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 12EMD Millipore, 49PharmGKB
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Pathways related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 19)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1OAT, OTC
2
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10.0OAT, ASS1
3
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10.0ACADM, HADHA
4
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9.9OTC, ASS1, OAT
5
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9.8ACADM, HMGCL, HADHA
6
Hide members
9.6GOT1, GOT2
7
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9.5HADHA, HMGCR, HMGCL, ACADM
8
Hide members
9.3PC, GOT2, GOT1
9
Hide members
9.3PC, GOT2, GOT1
109.2GOT1, GOT2, GPT
119.2GOT1, GOT1L1, GOT2
12
Hide members
9.2GOT1, GOT1L1, GOT2
138.8GLUL, GPT, GOT2, GOT1, OAT
148.8GLUL, GPT, ASS1, GOT2, GOT1
15
Hide members
8.8GLUL, OTC, ASS1, GOT2, GOT1, OAT
168.7GOT1, GOT2, ASS1, GPT, PC
178.4GLUL, GPT, OTC, ASS1, GOT2, GOT1
18
Hide members
8.4GLUL, PC, GPT, OTC, ASS1, GOT2
19
Hide members
7.7GPT, HMGCR, HMGCL, OTC, ACADM, ASS1

Compounds for genes affiliated with Reye Syndrome

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44Novoseek, 49PharmGKB, 24HMDB, 11DrugBank, 2BitterDB, 28IUPHAR
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Compounds related to Reye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1delta(1)pyrroline-5-carboxylate4410.3OTC, OAT, ASS1
2flavin semiquinone4410.3ETFDH, ACADM
3acetyl-l-carnitine4410.2ACADM, OTC, HADHA
4phenylacetic acid49 44 2412.2ASS1, OTC, PC
5ammonium4410.2GLUL, OTC, ASS1
6benzocaine44 11 2412.2HBG2, CES1
73-methylcrotonyl-coa44 2411.2HADHA, ACADM, PC
8riboflavin44 11 2412.2HBG2, ETFDH, ACADM
9citrulline44 2411.2OTC, ASS1, PC
10sodium benzoate49 211.1OTC, ASS1
11putrescine44 28 11 2413.1OAT, SLC22A5, OTC
12aminooxyacetic acid44 2811.1GLUL, GPT
133-hydroxy-3-methylglutaryl-coa44 2411.1CES1, HMGCL, HMGCR
14policosanol4410.0GPT, HMGCR
15ubiquinone4410.0HADHA, ETFDH, HMGCR
16decanoic acid44 28 1111.9ACADM, HADHA
17beta sitosterol449.9HMGCR, CES1
18campesterol44 2410.9HMGCR, CES1
19malate449.9GPT, GLUL, PC, OTC
20ezetimibe44 1110.9CES1, HMGCR, GPT
21carbamoyl phosphate449.9OAT, OTC, PC, GLUL, ASS1
22valproate449.9SLC22A5, GPT, OTC
23phosphoenolpyruvate44 1110.9OAT, ASS1, OTC, PC, GLUL
24alpha-ketoglutarate449.9GLUL, PC, OAT, GPT
25glycerol44 11 2411.9HBG2, OTC, PC, GLUL
26ornithine44 2410.9OAT, ASS1, OTC, GLUL, PC
27acetyl-coa44 2410.8HMGCL, ACADM, HADHA, PC
28valproic acid44 49 11 2412.8GPT, SLC22A5, OTC, ACADM
29carnitine449.7ACADM, PC, OTC, SLC22A5, HADHA
30carbon449.7PC, HBG2, HMGCR, GLUL
31L-Aspartic Acid11 2410.7GOT1, GOT2, ASS1
32niacin44 1110.7HMGCR, CES1, GPT, SLC22A5
33acyl-coa449.6HADHA, ETFDH, PC, CES1, ACADM, OTC
34u18666a449.6CES1, HMGCR
35fatty acid449.6ACADM, CES1, HADHA, ETFDH, OTC, PC
36nadh44 11 2411.5HMGCR, HADHA, PC, HBG2, ASS1
37aspartate449.4OTC, OAT, ASS1, GPT, PC, GLUL
38pyruvate449.4PC, OTC, HADHA, GLUL, GPT, ASS1
39Pyridoxal Phosphate119.4GOT2, GOT1, OAT, GPT
40famotidine44 2 11 2412.4GOT1, GOT2, OAT, GPT
41urea44 11 2411.3GPT, OTC, CES1, PC, GLUL, OAT
42glutamine449.3HADHA, GLUL, PC, GPT, OTC, OAT
43l-glutamic acid28 11 2411.2OAT, GLUL, GPT, GOT2, GOT1
44glucose449.1PC, CES1, OTC, GPT, ACADM, GLUL
45creatinine449.0HBG2, ASS1, OTC, HMGCR, HADHA, GLUL
46alanine449.0PC, HBG2, HADHA, GPT, ASS1, GLUL
47glutamate449.0GLUL, PC, GPT, OTC, ACADM, ASS1
48lactate448.9HMGCR, OTC, ACADM, HBG2, HADHA, PC
49lipid448.7CES1, GPT, ACADM, OTC, HMGCR, HBG2
50arginine448.6ASS1, GLUL, HBG2, GPT, HMGCR, SLC22A5

GO Terms for genes affiliated with Reye Syndrome

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16Gene Ontology
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Cellular components related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial inner membraneGO:0057439.0GOT2, OTC, HMGCL, PC, HADHA
2mitochondrial matrixGO:0057598.6OAT, ETFDH, PC, HMGCL, OTC, ACADM
3mitochondrionGO:0057397.8HADHA, GLUL, PC, DHTKD1, HMGCL, OTC

Biological processes related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:00652610.3OTC, ASS1
2fatty acid beta-oxidation using acyl-CoA dehydrogenaseGO:03353910.2ACADM, ETFDH
3liver developmentGO:00188910.0ACADM, OTC, HMGCL
4urea cycleGO:00005010.0OTC, ASS1
5aspartate biosynthetic processGO:0065329.8GOT1, GOT2
6glutamate catabolic process to aspartateGO:0195509.8GOT1, GOT2
7glutamate catabolic process to 2-oxoglutarateGO:0195519.8GOT1, GOT2
8aspartate catabolic processGO:0065339.7GOT2, GOT1
9aspartate metabolic processGO:0065319.7GOT2, GOT1
10cellular lipid metabolic processGO:0442559.7ACADM, HMGCL, HMGCR, HADHA
11oxaloacetate metabolic processGO:0061079.6PC, GOT2, GOT1
12glutamate metabolic processGO:0065369.6GOT2, GOT1
132-oxoglutarate metabolic processGO:0061039.6GOT1, GOT2
14gluconeogenesisGO:0060949.3GOT1, GOT2, GPT, PC
15cellular amino acid biosynthetic processGO:0086529.1GLUL, GPT, GOT2, GOT1, OAT
16glucose metabolic processGO:0060069.0GOT1, GOT2, PC
17cellular nitrogen compound metabolic processGO:0346418.7GLUL, GPT, OTC, ASS1, GOT2, GOT1
18small molecule metabolic processGO:0442817.3OAT, HADHA, ETFDH, GLUL, PC, GPT

Molecular functions related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fatty-acyl-CoA bindingGO:00006210.0HMGCL, HADHA
2carboxylic acid bindingGO:0314069.7GOT1, HMGCL
3transaminase activityGO:0084839.7GOT1, GOT1L1
4L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.6GOT1, GOT2
5L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.6GOT2, GOT1
6pyridoxal phosphate bindingGO:0301708.7OAT, GOT1, GOT1L1, GOT2, GPT

Products for genes affiliated with Reye Syndrome

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Sources for Reye Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet