RS
MCID: RYS001
MIFTS: 53

Reye Syndrome (RS) malady

Rare diseases, Neuronal diseases, Bone diseases, Liver diseases categories

Summaries for Reye Syndrome

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35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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NINDS:45 Reye's syndrome (RS) is primarily a children's disease, although it can occur at any age. It affects all organs of the body but is most harmful to the brain and the liver--causing an acute increase of pressure within the brain and, often, massive accumulations of fat in the liver and other organs. RS is defined as a two-phase illness because it generally occurs in conjunction with a previous viral infection, such as the flu or chicken pox. The disorder commonly occurs during recovery from a viral infection, although it can also develop 3 to 5 days after the onset of the viral illness. RS is often misdiagnosed as encephalitis, meningitis, diabetes, drug overdose, poisoning, sudden infant death syndrome, or psychiatric illness. Symptoms of RS include persistent or recurrent vomiting, listlessness, personality changes such as irritability or combativeness, disorientation or confusion, delirium, convulsions, and loss of consciousness. If these symptoms are present during or soon after a viral illness, medical attention should be sought immediately. The symptoms of RS in infants do not follow a typical pattern; for example, vomiting does not always occur. Epidemiologic evidence indicates that aspirin (salicylate) is the major preventable risk factor for Reye's syndrome. The mechanism by which aspirin and other salicylates trigger Reye's syndrome is not completely understood. A "Reye's-like" illness may occur in children with genetic metabolic disorders and other toxic disorders. A physician should be consulted before giving a child any aspirin or anti-nausea medicines during a viral illness, which can mask the symptoms of RS.

MalaCards: Reye Syndrome, also known as reye's syndrome, is related to hypoglycemia and myopathy. An important gene associated with Reye Syndrome is OTC (ornithine carbamoyltransferase), and among its related pathways are Valine, leucine and isoleucine degradation and glutamate degradation X. The drug perphenazine and the compounds sodium phenylbutyrate and sodium benzoate have been mentioned in the context of this disorder. Affiliated tissues include liver, brain and bone.

MedlinePlus:35 Reye syndrome is a rare illness that can affect the blood, liver, and brain of someone who has recently had a viral infection. it always follows another illness. although it mostly affects children and teens, anyone can get it. it can develop quickly and without warning. it is most common during flu season. symptoms include nausea and vomiting listlessness personality change - such as irritability, combativeness or confusion delirium convulsions loss of consciousness if these symptoms occur soon after a viral illness, seek medical attention immediately. reye syndrome can lead to a coma and brain death, so quick diagnosis and treatment are critical. treatment focuses on preventing brain damage. there is no cure. the cause of reye syndrome is unknown. studies have shown that taking aspirin increases the risk of getting it. because of that, health care professionals now recommend other pain relievers for young patients. nih: national institute of neurological disorders and stroke

Wikipedia:66 Reye syndrome or Reye\'s syndrome is a potentially fatal syndrome that has numerous detrimental effects... more...

Aliases & Classifications for Reye Syndrome

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 45NINDS, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 41NCIt, 36MeSH, 59SNOMED-CT, 28ICD9CM, 37MESH via Orphanet, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Bone diseases, Liver diseases


Aliases & Descriptions:

reye syndrome 9 44 11 46 35 63
reye's syndrome 9 44 45 50
fatty liver with encephalopathy 44
rs 44


External Ids:

Disease Ontology9 DOID:14525
NCIt41 C34983
MeSH36 D012202
ICD9CM28 331.81
MESH via Orphanet37 D012202
ICD10 via Orphanet27 G93.7
SNOMED-CT via Orphanet60 74351001
UMLS via Orphanet64 C0035400
ICD1026 G93.7

Related Diseases for Reye Syndrome

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18GeneCards, 19GeneDecks
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Diseases related to Reye Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1hypoglycemia30.0HMGCL, ACADM, PC
2myopathy30.0GOT2, GOT1, GLUL
3hepatocellular carcinoma29.8OTC, GLUL, GOT2, GOT1, ASS1
4influenza10.5
5hepatitis10.5
6cerebritis10.3
7chickenpox10.2
8kawasaki disease10.2
9connective tissue disease10.2
10argininosuccinic aciduria10.1OTC
11urea cycle disorder10.1ASS1
12methylmalonic acidemia10.1HMGCL
13alzheimer's disease10.1
14esophagitis10.1
15schizophrenia10.1
16hiv-110.1
17esophageal squamous cell carcinoma10.1
18ornithine carbamoyltransferase deficiency10.1HMGCL, OTC
19citrullinemia10.1ASS1, OTC
20maple syrup urine disease10.1OTC, HMGCL
21carbamoyl phosphate synthetase i deficiency disease10.1ASS1, OTC
22hyperargininemia10.1ASS1, OTC
23orotic aciduria10.1ASS1, OTC
24phenylketonuria10.1ACADM, OTC
25brain edema10.1GLUL, OTC
26lysinuric protein intolerance10.1ASS1, OTC
27homocystinuria10.1OTC, HMGCL
28hepatic encephalopathy10.1GLUL, ASS1
29organic acidemia10.1PC
30propionic acidemia10.1ASS1, HMGCL, OTC
31galactosemia10.0GLUL, ACADM
32hyperlysinemia10.0OTC, PC
33hepatitis a10.0GOT2, GOT1
34exanthem10.0GOT2, GOT1
35gallbladder disease10.0GOT1, GOT2
36chronic granulomatous disease10.0OTC, HBG2
37cholangitis10.0GOT1, GOT2
38acute intermittent porphyria10.0PC, GLUL
39acute pancreatitis10.0
40juvenile rheumatoid arthritis10.0
41systemic lupus erythematosus10.0
42sudden infant death syndrome10.0
43west syndrome10.0
443-methylcrotonyl-coa carboxylase deficiency10.0
45arthritis10.0
46gastroenteritis10.0
47herpes simplex10.0
48intellectual disability10.0
49liver disease10.0
50lupus erythematosus10.0

Graphical network of the top 20 diseases related to Reye Syndrome:



Diseases related to reye syndrome

Symptoms for Reye Syndrome

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Drugs & Therapeutics for Reye Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Reye Syndrome

Drug clinical trials:

Search ClinicalTrials for Reye Syndrome

Search NIH Clinical Center for Reye Syndrome

Search CenterWatch for Reye Syndrome

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Reye Syndrome

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Anatomical Context for Reye Syndrome

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34MalaCards
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MalaCards organs/tissues related to Reye Syndrome:

34
Liver, Brain, Bone, Kidney, Skin, Thalamus, Pons

Animal Models for Reye Syndrome or affiliated genes

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Publications for Reye Syndrome

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Sources:
53PubMed
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Articles related to Reye Syndrome:

(show top 50)    (show all 219)
idTitleAuthorsYear
1
Reye syndrome and liver transplantation. (21428204)
2010
2
Reye syndrome: a case report with review of literature. (18552890)
2008
3
Reye syndrome and reye-like syndrome. (18725066)
2008
4
A long-term follow-up of cognitive, emotional, and behavioural sequelae to Reye syndrome. (10479043)
1999
5
Frequency of 985A-to-G mutation in medium-chain acyl-CoA dehydrogenase gene among patients with sudden infant death syndrome, Reye syndrome, severe motor and intellectual disabilities and healthy newborns in Japan. (8840534)
1996
6
Medium-chain acylcoenzyme-A dehydrogenase deficiency. Not just another Reye syndrome. (8116590)
1993
7
Reye syndrome associated with subclinical varicella zoster virus and influenza A infection. (8388687)
1993
8
Role of influenza B virus in hepatic steatosis and mitochondrial abnormalities in a mouse model of Reye syndrome. (1846348)
1991
9
Argininosuccinate synthetase deficiency and reye syndrome-like presentation. (15815320)
1990
10
Isolated biotin-resistant 3-methylcrotonyl-CoA carboxylase deficiency presenting as a Reye syndrome-like illness. (2515383)
1989
11
Reye syndrome surveillance--United States, 1987 and 1988. (2496293)
1989
12
Progress in Reye syndrome: epidemiology, biochemical mechanisms and animal models. (2659225)
1989
13
Lipid storage myopathy associated with recurrent Reye syndrome-like attacks, but with a normal carnitine level. (3389475)
1988
14
Urinary evidence of disturbance of mitochondrial respiratory chain in Reye syndrome. (3598782)
1987
15
Reye syndrome: the Indian experience. (3440601)
1987
16
Reye syndrome surveillance--United States, 1986. (3116389)
1987
17
Reye syndrome in connective tissue disease. (3712152)
1986
18
Serum dicarboxylic acids in patients with Reye syndrome. (3746531)
1986
19
Reye syndrome and juvenile rheumatoid arthritis in Michigan. (4036917)
1985
20
Quantitative evaluation of the extent of hepatic enzyme changes in Reye syndrome compared with normal liver or with non-Reye liver disorders: objective criteria for animal models. (3969310)
1985
21
Reye syndrome associated with aspirin therapy for systemic lupus erythematosus. (4022693)
1985
22
Prognosis and diagnosis of Reye syndrome by discriminant analysis. (4043346)
1985
23
Metabolic and mitochondrial morphological changes that mimic Reye syndrome after endotoxin administration to rats. (3965406)
1985
24
The National Reye Syndrome Surveillance System, 1983. (6100127)
1984
25
National Reye syndrome surveillance--United States, 1982 and 1983. (6419053)
1984
26
Plasma fibronectin deficiency in Reye syndrome. (6470865)
1984
27
Leads from the MMWR. National Reye syndrome surveillance--United States. (6694302)
1984
28
Reye syndrome and salicylates. (7152783)
1982
29
Outcome in severe Reye syndrome with early pentobarbital coma and hypothermia. (7062223)
1982
30
Surgeon General's advisory on the use of salicylates and Reye syndrome. (6810083)
1982
31
Reye syndrome and aspirin use: the role of prodromal illness severity in the assessment of relative risk. (7079054)
1982
32
Reye syndrome: serum-induced alterations in brain mitochondrial function are blocked by fatty-acid-free albumin. (7193315)
1981
33
Epidemiology of Reye syndrome. (7030758)
1981
34
Monitoring and management of increased intracranial pressure in Reye syndrome: results in 29 children. (6773021)
1980
35
Treatment of Reye syndrome--importance of clinical staging. (7425578)
1980
36
Reye syndrome associated with vaccination with live virus vaccines. An exploration of possible etiologic relationships. (759059)
1979
37
Pb encephalopathy mimicking Reye syndrome. (469688)
1979
38
Reye syndrome outbreak in Michigan--preliminary report for early 1979. (431405)
1979
39
Recent developments in etiology and therapy of Reye syndrome. (568533)
1978
40
Short-chain fatty acids in Reye syndrome. (736536)
1978
41
Reye syndrome: light and electron microscopic studies of 7 cases. (754413)
1978
42
EEG correlations with biochemical abnormalities in Reye syndrome. (836179)
1977
43
Hepatic ATP concentrations and glycolytic enzyme activities in Reye syndrome. (185348)
1976
44
Letter: Post-transfusion viral infections in Reye syndrome. (178849)
1976
45
Letter: Reye syndrome. (937296)
1976
46
Intracranial pressure in Reye syndrome. Monitoring and control. (1172751)
1975
47
The treatment of Reye syndrome. (1185386)
1975
48
Reye syndrome with associated influenza A and B infection. (1174373)
1975
49
Letter: Clinical staging in Reye syndrome. (4440657)
1974
50
Reye syndrome. Light and electron microscopic studies. (4718229)
1973

Variations for Reye Syndrome

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Expression for genes affiliated with Reye Syndrome

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Reye Syndrome

Search GEO for disease gene expression data for Reye Syndrome.

Pathways for genes affiliated with Reye Syndrome

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Sources:
51PathCards, 31KEGG, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 61Thomson Reuters
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Pathways related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I39
valine degradation I39
pyruvate fermentation to lactate39
isoleucine degradation I39
9.9ACADM, HMGCL
2
Show member pathways
glutamate biosynthesis II39
arginine biosynthesis IV39
9.8ASS1, OTC
3
Show member pathways
aspartate biosynthesis39
9.4GOT2, GOT1
4
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.4GOT1, GOT2
5
Show member pathways
9.4GOT2, GOT1
68.7GLUL, GOT2, GOT1, ASS1
7
Show member pathways
8.6GOT1, GOT2, PC
8
Show member pathways
glycolysis39
gluconeogenesis39
Glycolysis and Gluconeogenesis39
8.6PC, GOT1, GOT2
9
Show member pathways
malate-aspartate shuttle39
glycogen biosynthesis II (from UDP-D-Glucose)39
8.6GOT1, GOT2, PC
10
Show member pathways
creatine-phosphate biosynthesis39
glycine degradation (creatine biosynthesis)39
putrescine biosynthesis III39
spermidine biosynthesis I39
tryptophan degradation via kynurenine39
spermine biosynthesis39
urea cycle39
S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I39
tyrosine degradation I39
L-carnitine biosynthesis39
methylthiopropionate biosynthesis39
2-oxoglutarate decarboxylation to succinyl-CoA39
S-methyl-5-thioadenosine degradation II39
8.4GOT2, ASS1, GLUL, OTC, GOT1
11
Show member pathways
citrulline-nitric oxide cycle39
arginine degradation I (arginase pathway)39
proline degradation39
glutamine degradation I39
proline biosynthesis I39
superpathway of citrulline metabolism39
proline biosynthesis II (from arginine)39
citrulline biosynthesis39
arginine degradation VI (arginase 2 pathway)39
Urea cycle and metabolism of amino groups39
asparagine biosynthesis I39
4-hydroxyproline degradation I39
citrulline degradation39
8.4OTC, GLUL, ASS1, GOT2, GOT1
128.2GOT1, GOT2, ASS1, PC
13
Show member pathways
L-serine degradation39
pentose phosphate pathway (oxidative branch)39
formaldehyde oxidation II (glutathione-dependent)39
7.3OTC, GLUL, PC, ACADM, ASS1, GOT2
14
Show member pathways
6.6OTC, GLUL, HMGCL, PC, ACADM, CES1

Compounds for genes affiliated with Reye Syndrome

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Sources:
52PharmGKB, 3BitterDB, 46Novoseek, 30IUPHAR, 12DrugBank, 25HMDB
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Compounds related to Reye Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 64)
idCompoundScoreTop Affiliating Genes
1sodium phenylbutyrate5210.2OTC, ASS1
2sodium benzoate52 311.2ASS1, OTC
3delta(1)pyrroline-5-carboxylate4610.2ASS1, OTC
4carbamate4610.1CES1, OTC
5acetyl-l-carnitine4610.1ACADM, OTC
6l-citrulline30 1211.1OTC, ASS1
7bamhi4610.0ACADM, OTC
8ammonium469.9GLUL, ASS1, OTC
93-Sulfinylpyruvic acid259.9GOT1, GOT2
103-Sulfopyruvic acid259.9GOT2, GOT1
11Cysteic acid259.8GOT1, GOT2
124-Hydroxyphenylpyruvic acid259.8GOT1, GOT2
13benzocaine46 25 1211.8HBG2, CES1
14Phenylpyruvic acid259.8GOT1, GOT2
153-Mercaptopyruvic acid259.8GOT1, GOT2
163-Sulfinoalanine25 1210.7GOT1, GOT2
17L-Tyrosine25 1210.7GOT1, GOT2
18L-Phenylalanine25 1210.6GOT1, GOT2
193-methylcrotonyl-coa46 2510.6ACADM, PC
20hydroxylamine469.5GLUL, HBG2
21L-Aspartic acid25 1210.5GOT1, GOT2, ASS1
22l-glutamic acid30 25 1211.5GOT1, GOT2, GLUL
23phenylacetic acid52 46 2511.4ASS1, PC, OTC
24L-Cysteine25 1210.4GOT2, GOT1
25riboflavin46 25 1211.4ACADM, HBG2
26malate469.4PC, OTC, GLUL
27citrulline46 2510.4ASS1, PC, OTC
28carnitine469.4PC, ACADM, OTC
29methylene469.2HBG2, ACADM
30creatinine469.1OTC, ASS1, HBG2, GLUL
31carbamoyl phosphate469.1ASS1, PC, GLUL, OTC
32acetyl-coa46 2510.1ACADM, PC, HMGCL
33phosphoenolpyruvate46 1210.1GLUL, PC, OTC, ASS1
34ornithine46 2510.1ASS1, PC, OTC, GLUL
35acyl-coa469.1OTC, PC, ACADM, CES1
36pyruvate469.1ASS1, PC, GLUL, OTC
37Oxalacetic acid259.1GOT1, GOT2, PC
38glucose 6-phosphate46 2510.0HBG2, PC, GLUL
39glutamine469.0OTC, ACADM, PC, GLUL
40fatty acid469.0OTC, CES1, ACADM, PC
41arginine468.9OTC, HBG2, ASS1, ACADM, GLUL
42aspartate468.9OTC, GLUL, PC, ASS1
43carbon468.8GLUL, PC, HBG2
44glycerol46 25 1210.8OTC, GLUL, HBG2, PC
45glutamate468.7PC, ASS1, OTC, ACADM, GLUL
46urea46 25 1210.7GLUL, PC, ASS1, OTC, CES1
47glucose468.6GLUL, PC, CES1, ACADM, OTC
48atp46 309.6OTC, PC, CES1, ASS1, GLUL
49lactate468.5HBG2, ACADM, PC, GLUL, OTC
50lipid468.1PC, CES1, GLUL, HBG2, OTC, ACADM

GO Terms for genes affiliated with Reye Syndrome

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17Gene Ontology
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Cellular components related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon terminusGO:0436799.6GLUL, GOT1
2mitochondrial inner membraneGO:0057438.2GOT2, PC, HMGCL, OTC
3mitochondrial matrixGO:0057598.2OTC, HMGCL, PC, ACADM, GOT2
4mitochondrionGO:0057397.3GOT2, DHTKD1, ACADM, PC, HMGCL, GLUL

Biological processes related to Reye Syndrome according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1arginine biosynthetic processGO:00652610.0ASS1, OTC
2urea cycleGO:0000509.9OTC, ASS1
3liver developmentGO:0018899.7OTC, HMGCL, ACADM
4glutamate catabolic process to aspartateGO:0195509.7GOT2, GOT1
5aspartate biosynthetic processGO:0065329.7GOT1, GOT2
6glutamate catabolic process to 2-oxoglutarateGO:0195519.7GOT2, GOT1
7aspartate catabolic processGO:0065339.6GOT1, GOT2
8aspartate metabolic processGO:0065319.6GOT2, GOT1
9response to starvationGO:0425949.6HMGCL, ACADM
10glutamate metabolic processGO:0065369.4GOT1, GOT2
11cellular amino acid biosynthetic processGO:0086529.4GOT2, GOT1, GLUL
122-oxoglutarate metabolic processGO:0061039.3GOT1, GOT2
13oxaloacetate metabolic processGO:0061078.9GOT1, PC, GOT2
14gluconeogenesisGO:0060948.8GOT1, PC, GOT2
15cellular nitrogen compound metabolic processGO:0346418.7OTC, GLUL, GOT2, GOT1, ASS1
16glucose metabolic processGO:0060068.7PC, GOT1, GOT2
17carbohydrate metabolic processGO:0059758.6GOT1, GOT2, PC
18small molecule metabolic processGO:0442817.3GOT1, OTC, HMGCL, GLUL, PC, ACADM

Molecular functions related to Reye Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carboxylic acid bindingGO:0314069.6GOT1, HMGCL
2manganese ion bindingGO:0301459.5GLUL, HMGCL
3L-aspartate:2-oxoglutarate aminotransferase activityGO:0040699.5GOT2, GOT1
4L-phenylalanine:2-oxoglutarate aminotransferase activityGO:0801309.4GOT2, GOT1
5pyridoxal phosphate bindingGO:0301709.4GOT2, GOT1

Products for genes affiliated with Reye Syndrome

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  • Antibodies
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Sources for Reye Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet