MCID: RHS001
MIFTS: 28

Rh Isoimmunization malady

Categories: Blood diseases

Aliases & Classifications for Rh Isoimmunization

Aliases & Descriptions for Rh Isoimmunization:

Name: Rh Isoimmunization 12 52 42 14 69
Rh Incompatibility Affecting Management of Mother 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4175
MeSH 42 D012203
NCIt 47 C113150
UMLS 69 C0035404

Summaries for Rh Isoimmunization

MalaCards based summary : Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to macular dystrophy, patterned, 1 and mental retardation, buenos aires type. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin). The drugs Darbepoetin alfa and Hematinics have been mentioned in the context of this disorder. Affiliated tissues include placenta and heart.

Related Diseases for Rh Isoimmunization

Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
id Related Disease Score Top Affiliating Genes
1 macular dystrophy, patterned, 1 10.3 RHCE RHD
2 mental retardation, buenos aires type 10.3 RHCE RHD
3 uterine corpus serous adenocarcinoma 10.2 AFP BCL10
4 bagassosis 10.2 AFP POMC
5 villonodular synovitis 10.2 EPO POMC
6 childhood kidney cell carcinoma 10.2 AFP POMC
7 agnosia 10.2 CSH1 CSH2
8 gastric teratoma 10.2 CSH1 CSH2
9 dacryoadenitis 10.1 EPO POMC
10 mutism 10.1 AFP CSH1 RHCE RHD
11 capillary leak syndrome 10.1 ALB NUMA1
12 lethal congenital contracture syndrome 10.1 AFP ALB
13 central nervous system endodermal sinus tumor 10.1 AFP CSH1 CSH2
14 flying phobia 10.1 AFP CSH1 CSH2
15 malignant teratoma 10.1 AFP CSH1 CSH2
16 renal artery disease 10.1 ALB RHCE
17 toxascariasis 10.1 AFP CSH1 CSH2
18 acantholytic acanthoma 10.0 CSH1 CSH2 MSH6
19 calcinosis 10.0 ALB EPO POMC
20 early-onset parkinson disease 10.0 BCL10 POMC
21 glucosephosphate dehydrogenase deficiency 10.0 ALB POMC
22 proctitis 10.0 AFP ALB MSH6
23 toxic encephalopathy 10.0 CSH1 CSH2 OXT
24 chronic tubotympanic suppurative otitis media 10.0 NUMA1 POMC
25 basal ganglia cerebrovascular disease 9.9 ALB EPO POMC RHCE RHD
26 thrombosis 9.9
27 pyelonephritis 9.9
28 eclampsia 9.9
29 ovarian mucinous cystadenocarcinoma 9.9 CSH1 CSH2 TFPI2
30 spinal multifocal clear cell meningioma 9.9 AFP CSH1 EPHA1 OXT PNLIP
31 spondylolysis 9.8 CSH1 CSH2 OXT POMC
32 blepharochalasis 9.7 AFP CSH1 CSH2 EPHA1 OXT PNLIP
33 echolalia 8.0 AFP ALB AMD1 BCL10 CSH1 CSH2

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to Rh Isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

Drugs & Therapeutics for Rh Isoimmunization

Drugs for Rh Isoimmunization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Darbepoetin alfa Approved, Investigational Phase 2, Phase 3 11096-26-7, 209810-58-2
2 Hematinics Phase 2, Phase 3

Interventional clinical trials:


id Name Status NCT ID Phase
1 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
2 EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine Transfusions Not yet recruiting NCT03104426 Phase 2, Phase 3
3 Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion Recruiting NCT03169907

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

Anatomical Context for Rh Isoimmunization

MalaCards organs/tissues related to Rh Isoimmunization:

39
Placenta, Heart

Publications for Rh Isoimmunization

Articles related to Rh Isoimmunization:

(show top 50) (show all 91)
id Title Authors Year
1
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. ( 23173411 )
2012
2
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. ( 21735053 )
2011
3
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. ( 21875319 )
2011
4
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. ( 21270966 )
2010
5
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. ( 20628321 )
2010
6
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. ( 20216236 )
2010
7
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. ( 17906023 )
2007
8
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. ( 14607036 )
2003
9
Ontogeny of the fetal immune system: study on pregnancies with Rh-isoimmunization and nonimmune fetal hydrops. ( 9884359 )
1999
10
Rho (D) immune globulin i.v. for prevention of Rh isoimmunization and for treatment of ITP. ( 8544794 )
1996
11
Prevention of Rh isoimmunization after spontaneous, massive fetomaternal hemorrhage. ( 8790318 )
1996
12
Rh isoimmunization complicating a triplet gestation. A case report. ( 1906542 )
1991
13
A case of Rh isoimmunization: should threatened first-trimester abortion be an indication for Rh immune globulin prophylaxis? ( 2115737 )
1990
14
Fetal heart rate responses to anemia in Rh isoimmunization. ( 2117061 )
1990
15
Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. ( 2119561 )
1990
16
Intrauterine transfusion via umbilical vein in severe Rh isoimmunization. ( 2499936 )
1989
17
Acute Rh isoimmunization following abdominal trauma associated with late abruption placenta. ( 2517184 )
1989
18
Prevention of Rh isoimmunization and treatment of the compromised fetus. ( 3146812 )
1988
19
Intravascular fetal blood transfusion under ultrasonic guidance in a case of severe Rh isoimmunization. ( 3150641 )
1988
20
Severe Rh isoimmunization--current methods of in utero diagnosis and treatment. ( 3132854 )
1988
21
Umbilical cord hematoma secondary to in utero intravascular transfusion for Rh isoimmunization. ( 3142213 )
1987
22
Fetal blood velocities in Rh isoimmunization: relationship to gestational age and to fetal hematocrit. ( 2942811 )
1986
23
Compliance with postpartum Rh isoimmunization prophylaxis in Alberta. ( 2996738 )
1985
24
Clinical experience with the prevention of Rh-isoimmunization: a historical comparative analysis. ( 6202159 )
1984
25
Circulating placental proteins in pregnancies complicated by RH isoimmunization. ( 6429588 )
1984
26
Rh isoimmunization following abdominal trauma: a case report. ( 6430091 )
1984
27
Histopathological study of placenta in Rh isoimmunization. ( 6418646 )
1983
28
Rh isoimmunization related to amniocentesis. ( 6419606 )
1983
29
Pathophysiology of Rh isoimmunization. ( 6809383 )
1982
30
Rh isoimmunization following genetic amniocentesis. ( 6815628 )
1982
31
Rh isoimmunization: a 24 year experience at Duke University Medical Center. ( 6791500 )
1981
32
Plasmapheresis as an adjunct to management of Rh isoimmunization. ( 7192839 )
1981
33
Ultrasonographic diagnosis of intervillous thrombosis related to Rh isoimmunization. ( 119677 )
1979
34
RH isoimmunization prevention program in a community hospital. ( 106231 )
1979
35
RH isoimmunization. ( 106230 )
1979
36
Rh isoimmunization during pregnancy: antenatal prophylaxis. ( 77714 )
1978
37
The management of Rh-Isoimmunization. ( 98742 )
1978
38
Suppression of Rh isoimmunization. A review. ( 101918 )
1978
39
Promethazine hydrochloride: use in patients with Rh isoimmunization. ( 637081 )
1978
40
Antenatal prophylaxis of Rh isoimmunization: 28-weeks'-gestation service program. ( 77715 )
1978
41
Rh isoimmunization, Manitoba, 1963-75. ( 402178 )
1977
42
Clinical observation of the prevention of RH isoimmunization with immunoglobulin anti-D. ( 4219865 )
1974
43
Sex ratio in Rh incompatibility and Rh isoimmunization. ( 4125603 )
1973
44
Oestriol conjugates in amniotic fluid. Qualitative and quantitative aspects, including preliminary studies in Rh isoimmunization. ( 4353745 )
1973
45
The clinical value of amniotic fluid analysis in pregnancies complicated by Rh-isoimmunization or hepatosis. ( 4631936 )
1973
46
The risk of Rh isoimmunization in ruptured tubal pregnancy. ( 4631183 )
1972
47
Ten-year experience with high titer anti-D plasma for the prevention of Rh isoimmunization. ( 4628388 )
1972
48
Plama estradiol, estriol, and progesterone in human pregnancy. II. Clinical applications in Rh-isoimmunization disease. ( 4628989 )
1972
49
The detection of anti-Rh O antibody as part of the programme in the prevention of Rh isoimmunization in Rh-negative mothers in Australia. ( 4112704 )
1972
50
Rh isoimmunization in ruptured pregnancy. ( 5083898 )
1972

Variations for Rh Isoimmunization

Expression for Rh Isoimmunization

Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for Rh Isoimmunization

GO Terms for Rh Isoimmunization

Cellular components related to Rh Isoimmunization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.32 AFP ALB CSH1 CSH2 EPGN EPO

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 response to electrical stimulus GO:0051602 9.32 EPO OXT
2 response to food GO:0032094 9.26 BCL10 OXT
3 organic cation transport GO:0015695 9.16 RHCE RHD
4 ammonium transmembrane transport GO:0072488 8.96 RHCE RHD
5 ammonium transport GO:0015696 8.62 RHCE RHD

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 CSH1 CSH2 EPO OXT POMC
2 ammonium transmembrane transporter activity GO:0008519 8.96 RHCE RHD

Sources for Rh Isoimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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