MCID: RHS001
MIFTS: 30

Rh Isoimmunization

Categories: Blood diseases

Aliases & Classifications for Rh Isoimmunization

MalaCards integrated aliases for Rh Isoimmunization:

Name: Rh Isoimmunization 12 51 41 14 69
Rh Incompatibility Affecting Management of Mother 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4175
MeSH 41 D012203
NCIt 46 C113150
UMLS 69 C0035404

Summaries for Rh Isoimmunization

MalaCards based summary : Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to rh-null, regulator type and retinohepatoendocrinologic syndrome. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin). Affiliated tissues include placenta and heart.

Related Diseases for Rh Isoimmunization

Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 rh-null, regulator type 10.5 RHCE RHD
2 retinohepatoendocrinologic syndrome 10.5 RHCE RHD
3 pancreatic acinar cell adenocarcinoma 10.4 AFP BCL10
4 orofaciodigital syndrome viii 10.4 AFP BCL10
5 blood group incompatibility 10.4 CSH1 RHCE RHD
6 anemia, autoimmune hemolytic 10.4 RHCE RHD
7 tuberculous epididymitis 10.4 AFP POMC
8 sheehan syndrome 10.3 EPO POMC
9 central nervous system germ cell tumor 10.3 AFP POMC
10 testicular trophoblastic tumor 10.3 CSH1 CSH2
11 splenic disease 10.3 ALB EPO
12 hepatoid adenocarcinoma 10.3 AFP ALB
13 choriocarcinoma of ovary 10.3 CSH1 CSH2
14 glossopharyngeal neuralgia 10.3 NUMA1 POMC
15 pyuria 10.3 ALB NUMA1
16 esophageal varix 10.2 AFP ALB
17 gastric lymphoma 10.2 ALB BCL10
18 chorioangioma 10.2 AFP OXT
19 autoimmune disease of blood 10.2 RHCE RHD
20 pure red-cell aplasia 10.2 ALB EPO
21 euthyroid sick syndrome 10.2 ALB POMC
22 gestational trophoblastic neoplasm 10.2 CSH1 CSH2
23 testicular granulosa cell tumor 10.1 AFP CSH1 CSH2
24 juvenile type testicular granulosa cell tumor 10.1 AFP CSH1 CSH2
25 choriocarcinoma of the testis 10.1 AFP CSH1 CSH2
26 germ cell and embryonal cancer 10.1 AFP CSH1 CSH2
27 endodermal sinus tumor 10.1 AFP ALB
28 syndrome of inappropriate antidiuretic hormone 10.1 ALB POMC
29 hypersplenism 10.1 ALB EPO
30 dicrocoeliasis 10.1 ALB EPGN
31 urinary system disease 10.1 ALB EPO POMC
32 gastrointestinal system cancer 10.1 AFP ALB MSH6
33 non-gestational choriocarcinoma 10.0 CSH1 CSH2 MSH6
34 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.9
35 aging 9.9
36 thrombosis 9.9
37 pyelonephritis 9.9
38 hemosiderosis 9.9
39 eclampsia 9.9
40 hemangioma of intra-abdominal structure 9.8 AFP OXT
41 fetal erythroblastosis 9.8 ALB EPO POMC RHCE RHD
42 choriocarcinoma 9.7 CSH1 CSH2 TFPI2
43 female reproductive system disease 9.6 CSH1 CSH2 OXT POMC
44 uterine anomalies 9.3 AFP CSH1 CSH2 EPHA1 OXT PNLIP
45 placenta disease 9.3 AFP CSH1 CSH2 EPHA1 OXT PNLIP

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to Rh Isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

Drugs & Therapeutics for Rh Isoimmunization

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Doppler or Amniocentesis to Predict Fetal Anemia Completed NCT00295516 Phase 3
2 Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion Recruiting NCT03169907

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

Anatomical Context for Rh Isoimmunization

MalaCards organs/tissues related to Rh Isoimmunization:

38
Placenta, Heart

Publications for Rh Isoimmunization

Articles related to Rh Isoimmunization:

(show top 50) (show all 92)
# Title Authors Year
1
Discordant intrauterine transfusion in dichorionic twin pregnancy with Rh isoimmunization. ( 29153312 )
2017
2
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. ( 23173411 )
2012
3
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. ( 21875319 )
2011
4
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. ( 21735053 )
2011
5
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. ( 21270966 )
2010
6
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. ( 20628321 )
2010
7
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. ( 20216236 )
2010
8
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. ( 17906023 )
2007
9
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. ( 14607036 )
2003
10
Ontogeny of the fetal immune system: study on pregnancies with Rh-isoimmunization and nonimmune fetal hydrops. ( 9884359 )
1999
11
Rho (D) immune globulin i.v. for prevention of Rh isoimmunization and for treatment of ITP. ( 8544794 )
1996
12
Prevention of Rh isoimmunization after spontaneous, massive fetomaternal hemorrhage. ( 8790318 )
1996
13
Rh isoimmunization complicating a triplet gestation. A case report. ( 1906542 )
1991
14
A case of Rh isoimmunization: should threatened first-trimester abortion be an indication for Rh immune globulin prophylaxis? ( 2115737 )
1990
15
Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. ( 2119561 )
1990
16
Fetal heart rate responses to anemia in Rh isoimmunization. ( 2117061 )
1990
17
Intrauterine transfusion via umbilical vein in severe Rh isoimmunization. ( 2499936 )
1989
18
Acute Rh isoimmunization following abdominal trauma associated with late abruption placenta. ( 2517184 )
1989
19
Prevention of Rh isoimmunization and treatment of the compromised fetus. ( 3146812 )
1988
20
Severe Rh isoimmunization--current methods of in utero diagnosis and treatment. ( 3132854 )
1988
21
Intravascular fetal blood transfusion under ultrasonic guidance in a case of severe Rh isoimmunization. ( 3150641 )
1988
22
Umbilical cord hematoma secondary to in utero intravascular transfusion for Rh isoimmunization. ( 3142213 )
1987
23
Fetal blood velocities in Rh isoimmunization: relationship to gestational age and to fetal hematocrit. ( 2942811 )
1986
24
Compliance with postpartum Rh isoimmunization prophylaxis in Alberta. ( 2996738 )
1985
25
Rh isoimmunization following abdominal trauma: a case report. ( 6430091 )
1984
26
Clinical experience with the prevention of Rh-isoimmunization: a historical comparative analysis. ( 6202159 )
1984
27
Circulating placental proteins in pregnancies complicated by RH isoimmunization. ( 6429588 )
1984
28
Rh isoimmunization related to amniocentesis. ( 6419606 )
1983
29
Histopathological study of placenta in Rh isoimmunization. ( 6418646 )
1983
30
Pathophysiology of Rh isoimmunization. ( 6809383 )
1982
31
Rh isoimmunization following genetic amniocentesis. ( 6815628 )
1982
32
Plasmapheresis as an adjunct to management of Rh isoimmunization. ( 7192839 )
1981
33
Rh isoimmunization: a 24 year experience at Duke University Medical Center. ( 6791500 )
1981
34
Ultrasonographic diagnosis of intervillous thrombosis related to Rh isoimmunization. ( 119677 )
1979
35
RH isoimmunization prevention program in a community hospital. ( 106231 )
1979
36
RH isoimmunization. ( 106230 )
1979
37
The management of Rh-Isoimmunization. ( 98742 )
1978
38
Antenatal prophylaxis of Rh isoimmunization: 28-weeks'-gestation service program. ( 77715 )
1978
39
Promethazine hydrochloride: use in patients with Rh isoimmunization. ( 637081 )
1978
40
Suppression of Rh isoimmunization. A review. ( 101918 )
1978
41
Rh isoimmunization during pregnancy: antenatal prophylaxis. ( 77714 )
1978
42
Rh isoimmunization, Manitoba, 1963-75. ( 402178 )
1977
43
Clinical observation of the prevention of RH isoimmunization with immunoglobulin anti-D. ( 4219865 )
1974
44
Oestriol conjugates in amniotic fluid. Qualitative and quantitative aspects, including preliminary studies in Rh isoimmunization. ( 4353745 )
1973
45
Sex ratio in Rh incompatibility and Rh isoimmunization. ( 4125603 )
1973
46
The clinical value of amniotic fluid analysis in pregnancies complicated by Rh-isoimmunization or hepatosis. ( 4631936 )
1973
47
The detection of anti-Rh O antibody as part of the programme in the prevention of Rh isoimmunization in Rh-negative mothers in Australia. ( 4112704 )
1972
48
Rh isoimmunization in ruptured pregnancy. ( 5083898 )
1972
49
Total protein content in amniotic fluid from normal pregnancies and from pregnancies complicated by rh-isoimmunization. ( 4558916 )
1972
50
Prevention of Rh isoimmunization. ( 4110995 )
1972

Variations for Rh Isoimmunization

Expression for Rh Isoimmunization

Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for Rh Isoimmunization

GO Terms for Rh Isoimmunization

Cellular components related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 AFP ALB EPGN EPO OXT PNLIP
2 extracellular region GO:0005576 9.32 AFP ALB CSH1 CSH2 EPGN EPO

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to electrical stimulus GO:0051602 9.37 EPO OXT
2 regulation of receptor activity GO:0010469 9.35 CSH1 CSH2 EPO OXT POMC
3 response to food GO:0032094 9.32 BCL10 OXT
4 organic cation transport GO:0015695 9.26 RHCE RHD
5 ammonium transmembrane transport GO:0072488 9.16 RHCE RHD
6 ammonium transport GO:0015696 8.62 RHCE RHD

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 OXT POMC
2 hormone activity GO:0005179 9.02 CSH1 CSH2 EPO OXT POMC
3 ammonium transmembrane transporter activity GO:0008519 8.96 RHCE RHD

Sources for Rh Isoimmunization

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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