MCID: RHS001
MIFTS: 28

Rh Isoimmunization malady

Category: Blood diseases

Aliases & Classifications for Rh Isoimmunization

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Aliases & Descriptions for Rh Isoimmunization:

Name: Rh Isoimmunization 11 50 39 13 68
 
Rh Incompatibility Affecting Management of Mother 11

Classifications:



External Ids:

Disease Ontology11 DOID:4175
MeSH39 D012203
NCIt45 C113150

Summaries for Rh Isoimmunization

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MalaCards based summary: Rh Isoimmunization, also known as rh incompatibility affecting management of mother, is related to macular dystrophy, patterned, 1 and mental retardation, buenos aires type. An important gene associated with Rh Isoimmunization is EPO (Erythropoietin). The drug rho(d) immune globulin, human has been mentioned in the context of this disorder. Affiliated tissues include placenta and heart.

Related Diseases for Rh Isoimmunization

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Diseases related to Rh Isoimmunization via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
idRelated DiseaseScoreTop Affiliating Genes
1macular dystrophy, patterned, 110.3RHCE, RHD
2mental retardation, buenos aires type10.3RHCE, RHD
3uterine corpus serous adenocarcinoma10.2AFP, BCL10
4bagassosis10.2AFP, POMC
5villonodular synovitis10.2EPO, POMC
6childhood kidney cell carcinoma10.2AFP, POMC
7agnosia10.2CSH1, CSH2
8gastric teratoma10.2CSH1, CSH2
9dacryoadenitis10.1EPO, POMC
10mutism10.1AFP, CSH1, RHCE, RHD
11capillary leak syndrome10.1ALB, NUMA1
12lethal congenital contracture syndrome10.1AFP, ALB
13central nervous system endodermal sinus tumor10.1AFP, CSH1, CSH2
14flying phobia10.1AFP, CSH1, CSH2
15malignant teratoma10.1AFP, CSH1, CSH2
16renal artery disease10.1ALB, RHCE
17toxascariasis10.1AFP, CSH1, CSH2
18acantholytic acanthoma10.0CSH1, CSH2, MSH6
19calcinosis10.0ALB, EPO, POMC
20early-onset parkinson disease10.0BCL10, POMC
21glucosephosphate dehydrogenase deficiency10.0ALB, POMC
22proctitis10.0AFP, ALB, MSH6
23toxic encephalopathy10.0CSH1, CSH2, OXT
24chronic tubotympanic suppurative otitis media10.0NUMA1, POMC
25basal ganglia cerebrovascular disease9.9ALB, EPO, POMC, RHCE, RHD
26thrombosis9.9
27pyelonephritis9.9
28eclampsia9.9
29ovarian mucinous cystadenocarcinoma9.9CSH1, CSH2, TFPI2
30spinal multifocal clear cell meningioma9.9AFP, CSH1, EPHA1, OXT, PNLIP
31spondylolysis9.8CSH1, CSH2, OXT, POMC
32blepharochalasis9.7AFP, CSH1, CSH2, EPHA1, OXT, PNLIP
33echolalia8.0AFP, ALB, AMD1, BCL10, CSH1, CSH2

Graphical network of the top 20 diseases related to Rh Isoimmunization:



Diseases related to rh isoimmunization

Symptoms & Phenotypes for Rh Isoimmunization

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Drugs & Therapeutics for Rh Isoimmunization

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Drugs for Rh Isoimmunization (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Darbepoetin alfaapproved, investigationalPhase 2, Phase 317711096-26-7, 209810-58-2
Synonyms:
 
Darbepoetin
Darbepoetin alfa,recombinant
2HematinicsPhase 2, Phase 31684

Interventional clinical trials:

idNameStatusNCT IDPhase
1Doppler or Amniocentesis to Predict Fetal AnemiaCompletedNCT00295516Phase 3
2EPO-4-Rhesus: Role of Darbepoetin Alfa in Reducing Late Anaemia in Neonates With Red Blood Cell Alloimmunization After Intrauterine TransfusionsNot yet recruitingNCT03104426Phase 2, Phase 3
3Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood TransfusionRecruitingNCT03169907

Search NIH Clinical Center for Rh Isoimmunization

Inferred drug relations via UMLS68/NDF-RT46:


Cochrane evidence based reviews: rh isoimmunization

Genetic Tests for Rh Isoimmunization

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Anatomical Context for Rh Isoimmunization

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MalaCards organs/tissues related to Rh Isoimmunization:

36
Placenta, Heart

Publications for Rh Isoimmunization

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Articles related to Rh Isoimmunization:

(show top 50)    (show all 91)
idTitleAuthorsYear
1
Comparison between two treatment protocols with recombinant human erythropoietin (rHuEpo) in the treatment of late anemia in neonates with Rh-isoimmunization. (23173411)
2012
2
Desferrioxamine treatment of iron overload secondary to RH isoimmunization and intrauterine transfusion in a newborn infant. (21735053)
2011
3
The effectiveness of recombinant human erythropoietin (EPO) treatment in a neonate with hyporegenerative anemia following Rh isoimmunization in spite of normal serum Epo level. (21875319)
2011
4
Rh isoimmunization in Sub-Saharan Africa indicates need for universal access to anti-RhD immunoglobulin and effective management of D-negative pregnancies. (21270966)
2010
5
Isolated early onset anemia after rh isoimmunization: a unique presentation in 3 neonates. (20628321)
2010
6
Recombinant human erythropoietin in the prevention of late anemia in intrauterine transfused neonates with Rh-isoimmunization. (20216236)
2010
7
Intraperitoneal transfusion in severe, early-onset Rh isoimmunization. (17906023)
2007
8
Noninvasive management of Rh partial null (D--) to supplement traditional management of Rh isoimmunization. (14607036)
2003
9
Ontogeny of the fetal immune system: study on pregnancies with Rh-isoimmunization and nonimmune fetal hydrops. (9884359)
1999
10
Rho (D) immune globulin i.v. for prevention of Rh isoimmunization and for treatment of ITP. (8544794)
1996
11
Prevention of Rh isoimmunization after spontaneous, massive fetomaternal hemorrhage. (8790318)
1996
12
Rh isoimmunization complicating a triplet gestation. A case report. (1906542)
1991
13
A case of Rh isoimmunization: should threatened first-trimester abortion be an indication for Rh immune globulin prophylaxis? (2115737)
1990
14
Fetal heart rate responses to anemia in Rh isoimmunization. (2117061)
1990
15
Placental transfer of cefazolin and piperacillin in pregnancies remote from term complicated by Rh isoimmunization. (2119561)
1990
16
Intrauterine transfusion via umbilical vein in severe Rh isoimmunization. (2499936)
1989
17
Acute Rh isoimmunization following abdominal trauma associated with late abruption placenta. (2517184)
1989
18
Prevention of Rh isoimmunization and treatment of the compromised fetus. (3146812)
1988
19
Intravascular fetal blood transfusion under ultrasonic guidance in a case of severe Rh isoimmunization. (3150641)
1988
20
Severe Rh isoimmunization--current methods of in utero diagnosis and treatment. (3132854)
1988
21
Umbilical cord hematoma secondary to in utero intravascular transfusion for Rh isoimmunization. (3142213)
1987
22
Fetal blood velocities in Rh isoimmunization: relationship to gestational age and to fetal hematocrit. (2942811)
1986
23
Compliance with postpartum Rh isoimmunization prophylaxis in Alberta. (2996738)
1985
24
Clinical experience with the prevention of Rh-isoimmunization: a historical comparative analysis. (6202159)
1984
25
Circulating placental proteins in pregnancies complicated by RH isoimmunization. (6429588)
1984
26
Rh isoimmunization following abdominal trauma: a case report. (6430091)
1984
27
Histopathological study of placenta in Rh isoimmunization. (6418646)
1983
28
Rh isoimmunization related to amniocentesis. (6419606)
1983
29
Pathophysiology of Rh isoimmunization. (6809383)
1982
30
Rh isoimmunization following genetic amniocentesis. (6815628)
1982
31
Rh isoimmunization: a 24 year experience at Duke University Medical Center. (6791500)
1981
32
Plasmapheresis as an adjunct to management of Rh isoimmunization. (7192839)
1981
33
Ultrasonographic diagnosis of intervillous thrombosis related to Rh isoimmunization. (119677)
1979
34
RH isoimmunization prevention program in a community hospital. (106231)
1979
35
RH isoimmunization. (106230)
1979
36
Rh isoimmunization during pregnancy: antenatal prophylaxis. (77714)
1978
37
The management of Rh-Isoimmunization. (98742)
1978
38
Suppression of Rh isoimmunization. A review. (101918)
1978
39
Promethazine hydrochloride: use in patients with Rh isoimmunization. (637081)
1978
40
Antenatal prophylaxis of Rh isoimmunization: 28-weeks'-gestation service program. (77715)
1978
41
Rh isoimmunization, Manitoba, 1963-75. (402178)
1977
42
Clinical observation of the prevention of RH isoimmunization with immunoglobulin anti-D. (4219865)
1974
43
Sex ratio in Rh incompatibility and Rh isoimmunization. (4125603)
1973
44
Oestriol conjugates in amniotic fluid. Qualitative and quantitative aspects, including preliminary studies in Rh isoimmunization. (4353745)
1973
45
The clinical value of amniotic fluid analysis in pregnancies complicated by Rh-isoimmunization or hepatosis. (4631936)
1973
46
The risk of Rh isoimmunization in ruptured tubal pregnancy. (4631183)
1972
47
Ten-year experience with high titer anti-D plasma for the prevention of Rh isoimmunization. (4628388)
1972
48
Plama estradiol, estriol, and progesterone in human pregnancy. II. Clinical applications in Rh-isoimmunization disease. (4628989)
1972
49
The detection of anti-Rh O antibody as part of the programme in the prevention of Rh isoimmunization in Rh-negative mothers in Australia. (4112704)
1972
50
Rh isoimmunization in ruptured pregnancy. (5083898)
1972

Variations for Rh Isoimmunization

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Expression for genes affiliated with Rh Isoimmunization

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Search GEO for disease gene expression data for Rh Isoimmunization.

Pathways for genes affiliated with Rh Isoimmunization

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GO Terms for genes affiliated with Rh Isoimmunization

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Cellular components related to Rh Isoimmunization according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055766.1AFP, ALB, CSH1, CSH2, EPGN, EPO

Biological processes related to Rh Isoimmunization according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ammonium transmembrane transportGO:007248810.5RHCE, RHD
2ammonium transportGO:001569610.5RHCE, RHD
3organic cation transportGO:001569510.5RHCE, RHD
4response to electrical stimulusGO:005160210.1EPO, OXT
5response to foodGO:00320949.7BCL10, OXT

Molecular functions related to Rh Isoimmunization according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ammonium transmembrane transporter activityGO:000851910.6RHCE, RHD
2hormone activityGO:00051798.6CSH1, CSH2, EPO, OXT, POMC

Sources for Rh Isoimmunization

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet