MCID: RHB017
MIFTS: 49

Rhabdoid Tumor malady

Cancer category

Summaries for Rhabdoid Tumor

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Malignant rhabdoid tumour (MRT) is a very aggressive form of tumour originally described as a variant of... more...

MalaCards: Rhabdoid Tumor is related to atypical teratoid rhabdoid tumor and wilms tumor. An important gene associated with Rhabdoid Tumor is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include lymph node, brain and cerebellum, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Rhabdoid Tumor

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

rhabdoid tumor 43 45 61


Related Diseases for Rhabdoid Tumor

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rhabdoid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 189)
idRelated DiseaseScoreTop Affiliating Genes
1atypical teratoid rhabdoid tumor31.7CLDN6, SMARCB1
2wilms tumor30.6SMARCB1, ACTC1, RASSF1, MYOD1, IGF1R, IGF2
3ganglioglioma30.4SYP
4choroid plexus carcinoma30.2SMARCB1
5fibrous histiocytoma30.2VIM, DES, ACTC1
6kidney rhabdoid cancer30.2SPP1, RASSF1, WT1
7adenocarcinoma30.2VIM, WT1, CTSD, SYP, IGF1R, MUC1
8beckwith-wiedemann syndrome30.0IGF1R, IGF2, WT1
9smooth muscle tumor30.0ACTC1, IGF2, DES, VIM
10pleomorphic adenoma30.0VIM, DES, IGF2, MUC1, ACTC1
11adenoma30.0CTSD, SYP, IGF2, IGF1R, MYOD1, MUC1
12papillary carcinoma30.0ACTC1, MUC1, SYP
13acute leukemia30.0SMARCB1, WT1
14rhabdoid tumors, somatic10.6
15tumor predisposition syndrome10.4
16rhabdoid tumor predisposition syndrome 210.4
17rhabdoid tumor predisposition syndrome 110.3
18hypercalcemia10.2
19childhood medulloblastoma10.2
20kid syndrome10.2
21soft tissue sarcoma10.2
22cerebral primitive neuroectodermal tumor10.0
23neurofibromatosis10.0
24renal wilms' tumor10.0
25myofibroma10.0
26junctional epidermolysis bullosa10.0
27canavan disease10.0
28supratentorial primitive neuroectodermal tumor10.0
29atypical neurofibroma10.0
30ectomesenchymoma10.0
31mutism10.0
32nodular medulloblastoma10.0
33n syndrome10.0
34pleomorphic xanthoastrocytoma10.0
35hydranencephaly10.0
36micro syndrome10.0
37phelan-mcdermid syndrome10.0
38atypical mole syndrome10.0
39chromosome 22q deletion10.0
40chylous ascites10.0
41heart tumor10.0
42malignant mesenchymal tumor10.0
43tuberculous meningitis10.0
4422q11.2 distal deletion syndrome10.0
45cataract, congenital10.0
46endometriosis10.0ACTC1
47congenital mesoblastic nephroma10.0SMARCB1
48neuroblastoma10.0SYP
49thyroid cancer10.0RASSF1
50hemangioma10.0ACTC1

Graphical network of the top 20 diseases related to Rhabdoid Tumor:



Diseases related to rhabdoid tumor

Clinical Features for Rhabdoid Tumor

Drugs & Therapeutics for Rhabdoid Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rhabdoid Tumor

Drug clinical trials:

Search ClinicalTrials for Rhabdoid Tumor

Search NIH Clinical Center for Rhabdoid Tumor

Search CenterWatch for Rhabdoid Tumor

Genetic Tests for Rhabdoid Tumor

Anatomical Context for Rhabdoid Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Rhabdoid Tumor:

33
Lymph node, Brain, Cerebellum, Spinal cord, Heart, Smooth muscle, Small intestine, Colon, Adipocyte, Kidney, Liver, Lung, Thyroid, Adrenal gland, Breast, Skin, Ovary, Uterus, Prostate, T cells, Fetal brain, Occipital lobe, Thalamus, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Uterus corpus

Animal Models for Rhabdoid Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Rhabdoid Tumor

Sources:
51PubMed
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Articles related to Rhabdoid Tumor:

(show top 50)    (show all 511)
idTitleAuthorsYear
1
Primary rhabdoid tumor with low grade glioma component of the central nervous system in a young adult. (22765644)
2013
2
Synchronous perivesical and renal malignant rhabdoid tumor in a 9-year-old boy: a case report and review of literature. (23830079)
2013
3
A primary malignant rhabdoid tumor in adult liver. (24255639)
2013
4
Primary supratentorial atypical teratoid/rhabdoid tumor in children: a report of two cases. (22550091)
2013
5
Differential expression of miRNAs in rhabdomyosarcoma and malignant rhabdoid tumor. (23000453)
2012
6
Evaluation of cerebellar mutism by arterial spin-labeling perfusion magnetic resonance imaging in a patient with atypical teratoid/rhabdoid tumor (AT/RT): a case report. (22476660)
2012
7
In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model. (22458853)
2012
8
Conventional chondrosarcoma in a survivor of rhabdoid tumor: enlarging the spectrum of tumors associated with SMARCB1 germline mutations. (23154773)
2012
9
Absence of chromosome 19q13.41 amplification in a case of atypical teratoid/rhabdoid tumor with ependymoblastic differentiation. (21086133)
2011
10
Atypical teratoid rhabdoid tumor mimicking beta-catenin-positive nodular medulloblastoma. (21229255)
2011
11
Primary atypical teratoid/rhabdoid tumor of the spine in an infant. (21311641)
2010
12
Proximal-type epithelioid sarcoma of the vulva: relationship to malignant extrarenal rhabdoid tumor. (20881848)
2010
13
Malignant rhabdoid tumor of the kidney combined with multicystic dysplasia in a 5-year-old child. (20436719)
2010
14
Case report of extrarenal rhabdoid tumor of pelvic retroperitoneum molecular profile of angiogenesis and its implication in new treatment strategy. (19276648)
2009
15
A case of congenital orbital malignant rhabdoid tumor: systemic metastasis following exenteration. (19390226)
2009
16
Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidney. (19260106)
2009
17
Dependence on PI3K/Akt signaling for malignant rhabdoid tumor cell survival. (18641990)
2009
18
Genomic analysis using high-density single nucleotide polymorphism-based oligonucleotide arrays and multiplex ligation-dependent probe amplification provides a comprehensive analysis of INI1/SMARCB1 in malignant rhabdoid tumors. (19276269)
2009
19
SMARCB1/INI1 alterations and hepatoblastoma: another extrarenal rhabdoid tumor revealed? (19072985)
2009
20
Malignant rhabdoid tumor of the parapharyngeal space. (19291622)
2009
21
Atypical teratoid/rhabdoid tumor of the central nervous system associated with congenital cataract. (18723966)
2008
22
Identification of CD133-positive radioresistant cells in atypical teratoid/rhabdoid tumor. (18509505)
2008
23
An immunohistochemical and electron microscopic study of atypical teratoid/rhabdoid tumor. (18987833)
2008
24
Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report. (16772877)
2006
25
Treatment of unresectable malignant rhabdoid tumor of the orbit with tandem high-dose chemotherapy and gamma-knife radiosurgery. (16534791)
2006
26
Atypical teratoid/rhabdoid tumor of the brain: cytopathologic characteristics and differential diagnosis. (15690353)
2005
27
Primary malignant rhabdoid tumor of the central nervous system--a comprehensive review. (15980975)
2005
28
Pathology teach and tell: malignant rhabdoid tumor of kidney. (15768866)
2004
29
Rhabdoid tumor: an unusual pediatric brain tumor. (14768507)
2003
30
Importance of re-examination for medulloblastoma and atypical teratoid/rhabdoid tumor. (14520545)
2003
31
Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. (12429635)
2002
32
Long-term survival after spontaneous rupture of a malignant rhabdoid tumor of the liver. (12378463)
2002
33
Extraneural metastasis in a child with atypical teratoid rhabdoid tumor of the central nervous system. (11763423)
2001
34
A malignant rhabdoid tumor of the kidney occurring concurrently with a brain tumor: report of a case. (10752788)
2000
35
Congenital disseminated malignant rhabdoid tumor: a distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11. (10078913)
1999
36
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. (9892189)
1999
37
Malignant rhabdoid tumor of the duodenum. (9845720)
1998
38
Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood. (9206002)
1997
39
Rhabdoid tumor of the kidney in children: a comparative study of 21 cases. (9016225)
1997
40
Gene expression of malignant rhabdoid tumor cell lines by reverse transcriptase-polymerase chain reaction. (9559292)
1997
41
Primary malignant rhabdoid tumor of the central nervous system. (9206001)
1997
42
Pathological case of the month. Rhabdoid tumor of the kidney. (9193254)
1997
43
Malignant rhabdoid tumor of the brain and kidney in a child: clinical and pathologic features. (7575853)
1995
44
Rhabdoid tumor of the central nervous system. (1637409)
1992
45
Malignant rhabdoid tumor arising from soft parts of the right thigh with unusual neurologic manifestation: report of a case. (1363393)
1992
46
Primary CNS malignant rhabdoid tumor (MRT): report of two cases and review of literature. (2015720)
1991
47
Fine-needle aspiration biopsy diagnosis of malignant rhabdoid tumor of the kidney. (2026082)
1991
48
Monosomy 22 in rhabdoid or atypical tumors of the brain. (2213160)
1990
49
Primitive neuroectodermal tumor of the brain associated with malignant rhabdoid tumor of the liver: a histologic, immunohistochemical, and electron microscopic study. (2546137)
1989
50
Monosomy 22 in rhabdoid or atypical teratoid tumors of the brain. (2770830)
1989

Genetic Variations for Rhabdoid Tumor

Expression for genes affiliated with Rhabdoid Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdoid Tumor

Search GEO for disease gene expression data for Rhabdoid Tumor.

Pathways for genes affiliated with Rhabdoid Tumor

Sources:
38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 52QIAGEN
See all sources

Compounds for genes affiliated with Rhabdoid Tumor

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 2BitterDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR
See all sources

Compounds related to Rhabdoid Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9MYOD1
2butyrate4510.8MYOD1
3s 1004510.8VIM, ACTC1, MUC1, SYP, DES
4reticulin4510.8VIM, DES, MUC1, ACTC1, SYP
5mucicarmine4510.8ACTC1, MUC1, SYP, VIM, DES
6hematoxylin4510.7DES, SYP, MUC1, ACTC1, VIM
7b 7234510.7ACTC1, SYP, MUC1, WT1, DES, VIM
8orcein4510.7VIM, DES, ACTC1
9formaldehyde45 2411.7VIM, CTSD, DES, MUC1, ACTC1, SYP
10progestin4510.7MUC1, CTSD, DES, IGF1R, IGF2, VIM
11glucose4510.7MUC1, ACTC1, CTSD, SMARCA4, IGF2, IGF1R
12glycogen45 2411.7IGF2, VIM, SYP, DES, ACTC1, IGF1R
13azathioprine45 50 2 1113.7IGF2, RASSF1, MYOD1, DES, VIM
14hyaluronic acid45 2411.6WT1, IGF1R, SPP1, MUC1, VIM, CTSD
15steroid4510.6ACTC1, SYP, SMARCA4, MYOD1, WT1, CTSD
16agar4510.6IGF1R, MUC1, RASSF1, SPP1, SMARCA4, CTSD
17creatinine4510.6SPP1, ACTC1, IGF1R, IGF2, SYP, CTSD
18estradiol45 11 2412.6DES, CTSD, VIM, SYP, IGF2, IGF1R
19adriamycin4510.6CTSD, IGF1R, MUC1, DES, VIM
20actinomycin d4510.6MUC1, VIM, DES, IGF2, MYOD1, SPP1
21etoposide45 50 60 1113.6WT1, SYP, IGF2, IGF1R, VIM, CTSD
22ribonucleic acid4510.6IGF1R, WT1, IGF2, ACTC1, MUC1, SPP1
23gold4510.6IGF1R, SYP, DES, CTSD, MUC1
24dihydrotestosterone45 29 11 2413.6IGF1R, IGF2, DES, VIM, MUC1
25lysine4510.6WT1, CTSD, MYOD1, DES, SMARCA4, IGF1R
26cisplatin45 50 60 1113.6MUC1, SPP1, IGF1R, IGF2, CTSD, RASSF1
2712-o-tetradecanoylphorbol 13-acetate4510.6VIM, CTSD, MUC1, MYOD1, DES, WT1
282-methoxyethanol4510.6ACTC1, VIM, IGF2
29progesterone45 60 29 11 2414.6SPP1, ACTC1, MUC1, IGF2, SYP, DES
30arginine4510.6SMARCA4, VIM, IGF2, IGF1R, SPP1, BMP1
31oligonucleotide4510.6VIM, IGF2, SPP1, WT1, IGF1R, MYOD1
32paraffin4510.5SPP1, VIM, WT1, CTSD, SYP, IGF2
33imatinib45 50 1112.5ACTC1, IGF2, WT1, IGF1R, DES
34vegf4510.5SPP1, ACTC1, MUC1, MYOD1, IGF1R, IGF2
35testosterone45 60 11 2413.5MYOD1, MUC1, ACTC1, SPP1, CTSD, SMARCA4
36cysteine4510.5VIM, SPP1, MUC1, MYOD1, SMARCA4, IGF1R
37threonine4510.5SPP1, WT1, MUC1, RASSF1, MYOD1, IGF1R
38alanine4510.5RASSF1, MYOD1, VIM, IGF1R, IGF2, BMP1
39retinoic acid45 2411.5ACTC1, CTSD, MUC1, MYOD1, SPP1, IGF1R
40h2o24510.5VIM, SPP1, SYP, DES, CTSD, IGF2
41forskolin45 50 1112.4MUC1, WT1, SYP, IGF2, IGF1R, VIM
42serine4510.4IGF1R, VIM, AURKA, WT1, BMP1, DES
434-hydroxytamoxifen4510.4IGF2, IGF1R, CTSD, VIM
44calcitriol45 60 11 2413.4CTSD, IGF2, IGF1R, WT1, SPP1
45tyrosine4510.4SPP1, SMARCA4, WT1, DES, SYP, IGF2
46calcium45 50 11 2413.3CTSD, INA, MYOD1, STIM1, IGF1R, SPP1
47chloramphenicol45 2 1112.3WT1, VIM, IGF2, MUC1, MYOD1
48dexamethasone45 50 29 1113.3IGF2, IGF1R, SPP1
49glutamine4510.3CTSD, WT1, VIM, SYP, IGF2, IGF1R
50lactate4510.0SPP1, IGF1R, VIM, IGF2, DES, CTSD

GO Terms for genes affiliated with Rhabdoid Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nBAF complexGO:07156510.4SMARCB1, SMARCA4
2npBAF complexGO:07156410.3SMARCB1, SMARCA4
3nuclear chromatinGO:00079010.1SMARCA4, MUC1, MYOD1

Biological processes related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.5ACTC1, DES, VIM
2blastocyst hatchingGO:00183510.4SMARCB1, SMARCA4
3extracellular matrix organizationGO:03019810.3SMARCA4, SPP1, BMP1, CTSD
4regulation of transcription from RNA polymerase II promoterGO:00635710.2WT1, MYOD1, SMARCA4, SMARCB1
5positive regulation by host of viral transcriptionGO:04392310.1SMARCB1, SMARCA4

Molecular functions related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00203910.4MUC1, SMARCA4, SMARCB1
2structural constituent of cytoskeletonGO:00520010.4INA, DES, VIM
3Tat protein bindingGO:03095710.3SMARCB1, SMARCA4
4identical protein bindingGO:04280210.3RASSF1, CLDN6, IGF1R, SYP, DES, STIM1
5protein bindingGO:0055159.7VIM, AURKA, WT1, CTSD, STIM1, DES

Products for genes affiliated with Rhabdoid Tumor

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  • Proteins
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  • Antibodies

Sources for Rhabdoid Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet