MCID: RHB017
MIFTS: 51

Rhabdoid Tumor malady

Rare diseases, Cancer diseases categories
Download this MalaCard

Summaries for Rhabdoid Tumor

About this section


Fully expand this MalaCard
Wikipedia:65 Malignant rhabdoid tumour (MRT) is a very aggressive form of tumour originally described as a variant of... more...

MalaCards based summary: Rhabdoid Tumor, also known as rhabdoid sarcoma, is related to ganglioglioma and choroid plexus carcinoma. An important gene associated with Rhabdoid Tumor is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are BRCA1 Pathway and Transcription Ligand dependent activation of the ESR1 SP pathway. The compounds eosin and orcein have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and liver, and related mouse phenotypes are digestive/alimentary and tumorigenesis.

Aliases & Classifications for Rhabdoid Tumor

About this section
Sources:
42NIH Rare Diseases, 62UMLS, 44Novoseek
See all sources

Rhabdoid Tumor, Aliases & Descriptions:

Name: Rhabdoid Tumor 42 44 62
 
Rhabdoid Sarcoma 42 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Related Diseases for Rhabdoid Tumor

About this section

Diseases related to Rhabdoid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 141)
idRelated DiseaseScoreTop Affiliating Genes
1ganglioglioma31.2SYP
2choroid plexus carcinoma31.0SMARCB1
3epithelioid sarcoma30.9SMARCB1, VIM, MUC1
4hemangioma30.7ACTC1
5medulloblastoma30.6SYP, ACTC1, SMARCB1, IGF2, DES
6fibrous histiocytoma30.4DES, VIM, ACTC1
7wilms tumor30.3DES, IGF2, SMARCB1, VIM, ACTC1
8sarcoma30.1DES, IGF2, SMARCB1, VIM, MUC1, ACTC1
9chondrosarcoma30.1MUC1, VIM, DES
10rhabdomyosarcoma30.0DES, IGF2, SMARCB1, VIM, ACTC1
11adenoma29.6SYP, ACTC1, MUC1, SMARCA4, IGF2
12pleomorphic adenoma29.5DES, IGF2, VIM, MUC1, ACTC1
13meningioma29.5IGF2, SMARCB1, VIM, MUC1, SYP
14adenocarcinoma29.3SPP1, SMARCA4, VIM, MUC1, ACTC1, SYP
15atypical teratoid rhabdoid tumor11.2
16rhabdoid tumors, somatic10.7
17neuroectodermal tumor10.6
18congenital mesoblastic nephroma10.5SMARCB1
19rhabdoid tumor predisposition syndrome 210.5
20retroperitoneal leiomyosarcoma10.5SMARCB1
21infantile myofibromatosis10.5DES
22neurilemmoma10.5SMARCB1
23fasciitis10.5ACTC1
24syringoma10.4MUC1
25melanotic neuroectodermal tumor10.4SYP
26cerebritis10.4
27cervicitis10.4
28fibrous meningioma10.4MUC1
29subependymal giant cell astrocytoma10.4SYP
30hidradenoma10.4MUC1
31tumor predisposition syndrome10.4
32adenomatoid tumor10.4VIM
33cystadenocarcinoma10.4MUC1
34rhabdoid tumor predisposition syndrome 110.4
35osteofibrous dysplasia10.3SPP1
36desmoid tumor10.3ACTC1, DES
37choroiditis10.3
38hepatoblastoma10.3
39thyroiditis10.3
40cutaneous fibrous histiocytoma10.3DES, ACTC1
41adenosarcoma10.3ACTC1, DES
42rhabdoid cancer10.3
43teratoma10.3ACTC1, SMARCB1
44desmoplastic small round cell tumor10.2DES, MUC1
45striated muscle rhabdoid tumor10.2
46hypercalcemia10.2
47pleomorphic xanthoastrocytoma10.2
48kidney rhabdoid cancer10.2
49histiocytoma10.2
50meningitis10.2

Graphical network of the top 20 diseases related to Rhabdoid Tumor:



Diseases related to rhabdoid tumor

Symptoms for Rhabdoid Tumor

About this section

Drugs & Therapeutics for Rhabdoid Tumor

About this section

Drug clinical trials:

Search ClinicalTrials for Rhabdoid Tumor

Search NIH Clinical Center for Rhabdoid Tumor

Genetic Tests for Rhabdoid Tumor

About this section

Anatomical Context for Rhabdoid Tumor

About this section

MalaCards organs/tissues related to Rhabdoid Tumor:

32
Kidney, Brain, Liver, Pineal, Lung, Cerebellum, Colon, Thyroid, Skin, Ovary, Uterus, Tongue, Lymph node, Spinal cord, Heart, Smooth muscle, Small intestine, Adipocyte, Adrenal gland, Breast, Prostate, Temporal lobe, Occipital lobe, Thalamus

Animal Models for Rhabdoid Tumor or affiliated genes

About this section

Publications for Rhabdoid Tumor

About this section

Articles related to Rhabdoid Tumor:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Large congenital melanocytic nevi with atypical teratoid/rhabdoid tumor. (23519929)
2013
2
CRX/OTX3: a useful marker in the differential diagnosis of tumors of the pineal region and indicator of photoreceptor differentiation in medulloblastomas and atypical teratoid rhabdoid tumors. (23235340)
2013
3
Primary rhabdoid tumor with low grade glioma component of the central nervous system in a young adult. (22765644)
2013
4
The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells. (23764045)
2013
5
Absence of oncogenic canonical pathway mutations in aggressive pediatric rhabdoid tumors. (22997201)
2012
6
Treatment-related morbidity in atypical teratoid/rhabdoid tumor: multifocal necrotizing leukoencephalopathy. (21613772)
2011
7
Supratentorial atypical teratoid rhabdoid tumor: An uncommon childhood tumor. (21977104)
2011
8
Nonsense mutation and inactivation of SMARCA4 (BRG1) in an atypical teratoid/rhabdoid tumor showing retained SMARCB1 (INI1) expression. (21566516)
2011
9
Systematic analysis of the antiproliferative effects of novel and standard anticancer agents in rhabdoid tumor cell lines. (20147838)
2010
10
Adult variant of atypical teratoid/rhabdoid tumor: immunohistochemical and ultrastructural confirmation of a rare tumor in the sella tursica. (20705400)
2010
11
Fetal and neonatal rhabdoid tumor. (20223330)
2010
12
Clinical and molecular features in patients with atypical teratoid rhabdoid tumor or malignant rhabdoid tumor. (19902524)
2010
13
Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors. (19221586)
2009
14
Atypical teratoid/rhabdoid tumor of the spine in a 4-year-old girl. (19073850)
2008
15
Atypical teratoid/rhabdoid tumor of the central nervous system associated with congenital cataract. (18723966)
2008
16
Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium. (17376508)
2007
17
Atypical teratoid/rhabdoid tumor of the spinal canal. (16411024)
2006
18
Absence of expression of SMARCB1/INI1 in malignant rhabdoid tumors of the central nervous system, kidneys and soft tissue: an immunohistochemical study with implications for diagnosis. (16528370)
2006
19
Treatment of stage IV malignant rhabdoid tumor of the kidney (MRTK) with ICE and VDCy: a case report. (16772877)
2006
20
Atypical teratoid rhabdoid tumor in a child with neurofibromatosis 1. (16086409)
2006
21
Cutaneous extrarenal rhabdoid tumor with myogenic differentiation. (16293182)
2005
22
Rhabdoid tumor of the thyroid gland: a variant of anaplastic carcinoma. (15737050)
2005
23
Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor. (15803379)
2005
24
E, N-cadherins and beta-catenin expression in medulloblastoma and atypical teratoid/rhabdoid tumor. (15508347)
2004
25
Cytologic profile of rhabdoid tumor of the kidney. A report of 3 cases. (14674079)
2003
26
The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. (11782395)
2002
27
Primary intracranial atypical teratoid/rhabdoid tumor in a child: a case report. (12378033)
2002
28
Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence. (11557780)
2001
29
Cytokeratin subunits of inclusion bodies in rhabdoid cells: immunohistochemical and clinicopathological study of malignant rhabdoid tumor and epithelioid sarcoma. (11469343)
2001
30
Atypical teratoid/rhabdoid tumor or medulloblastoma? (11344497)
2001
31
Abdominal rhabdoid tumor presenting as fetal hydrops: a case report. (11846311)
2001
32
CSF cytology of atypical teratoid/rhabdoid tumor of the brain in a two-year-old girl: a case report. (11074628)
2000
33
Malignant rhabdoid tumor: A phenotype? An entity?--A controversy revisited. (10809224)
2000
34
Congenital disseminated malignant rhabdoid tumor: a distinct clinicopathologic entity demonstrating abnormalities of chromosome 22q11. (10078913)
1999
35
Congenital malignant rhabdoid tumor of the orbit. (10532580)
1999
36
Rhabdoid tumor of the kidney arising in a newborn infant: description of a case with ultrastructural observations]. (10536466)
1999
37
Atypical teratoid/rhabdoid tumor--a stereogram unveiled. (10331072)
1999
38
Simultaneous presentation of atypical teratoid/rhabdoid tumor in siblings. (10448873)
1999
39
Pathologic quiz case. Extrarenal rhabdoid tumor. (10458840)
1999
40
Rhabdoid tumor of the kidney associated with a tumor of the posterior fossa. (9477277)
1998
41
Congenital malignant rhabdoid tumor presenting as a cutaneous nodule: report of 2 cases with review of the literature. (9870859)
1998
42
Central nervous system atypical teratoid/rhabdoid tumors of infancy and childhood. (9206002)
1997
43
Narrowing the critical region for a rhabdoid tumor locus in 22q11. (8818656)
1996
44
Carcinosarcoma (malignant mixed mA1llerian tumor) of the uterus with a rhabdoid tumor component. An immunohistochemical, ultrastructural, and immunoelectron microscopic case study. (7856569)
1995
45
Malignant rhabdoid tumor of the brain and kidney in a child: clinical and pathologic features. (7575853)
1995
46
Successful treatment of disseminated central nervous system malignant rhabdoid tumor. (7743242)
1995
47
Primary malignant rhabdoid tumor of the brain: clinical, imaging, and pathologic findings. (8427070)
1993
48
Clinical and imaging features of rhabdoid tumor of the kidney. (1897075)
1991
49
Poorly differentiated primary orbital sarcoma (presumed malignant rhabdoid tumor). Radiologic and histopathologic correlation. (1656924)
1991
50
Malignant rhabdoid tumor of the vulva: is distinction from epithelioid sarcoma possible? A pathologic and immunohistochemical study. (2476944)
1989

Variations for Rhabdoid Tumor

About this section

Expression for genes affiliated with Rhabdoid Tumor

About this section
Expression patterns in normal tissues for genes affiliated with Rhabdoid Tumor

Search GEO for disease gene expression data for Rhabdoid Tumor.

Pathways for genes affiliated with Rhabdoid Tumor

About this section

Pathways related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.8SMARCA4, SMARCB1
2
Show member pathways
Development Ligand dependent activation of the ESR1 AP 1 pathway60
9.8SMARCA4, SMARCB1
39.8SMARCB1, SMARCA4
49.6ACTC1, IGF2
5
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.4DES, VIM
69.1IGF2, SPP1
7
Show member pathways
9.1ACTC1, VIM, DES
89.1ACTC1, VIM, DES
9
Show member pathways
7.6SPP1, DES, IGF2, VIM, MUC1

Compounds for genes affiliated with Rhabdoid Tumor

About this section

Compounds related to Rhabdoid Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1eosin449.5MUC1, VIM
2orcein449.5ACTC1, VIM, DES
32-methoxyethanol449.3IGF2, VIM, ACTC1
4ganglioside449.3SYP, VIM, DES
5peg-10449.2IGF2, SPP1
6dbc-amp449.1SYP, VIM, IGF2
7azathioprine44 2 50 1112.1DES, IGF2, VIM
8biotin44 24 1110.9ACTC1, MUC1, VIM, DES
9polyethylene glycol448.8MUC1, IGF2, SPP1
10progestin448.8MUC1, VIM, IGF2, DES
11neomycin448.8SPP1, IGF2, VIM
12dihydrotestosterone44 28 24 1111.8DES, IGF2, VIM, MUC1
13hydrocortisone44 2 61 1111.7IGF2, VIM, MUC1
14steroid448.7SYP, ACTC1, SMARCA4, IGF2, DES
15procollagen448.6SPP1, DES, VIM, ACTC1
16adriamycin448.6DES, VIM, MUC1
17forskolin44 50 1110.6IGF2, VIM, MUC1, SYP
18ribonucleic acid448.6ACTC1, MUC1, IGF2, SPP1
19s 100448.5SYP, ACTC1, MUC1, VIM, DES
20reticulin448.5DES, VIM, MUC1, ACTC1, SYP
21mucicarmine448.5DES, VIM, MUC1, ACTC1, SYP
22b 723448.5DES, VIM, MUC1, ACTC1, SYP
23hematoxylin448.5DES, VIM, MUC1, ACTC1, SYP
24formaldehyde44 249.5DES, VIM, MUC1, ACTC1, SYP
25cyclic amp44 249.5DES, SMARCA4, VIM, MUC1, SYP
26matrigel448.5SPP1, VIM, MUC1, ACTC1
27hyaluronic acid44 249.5MUC1, VIM, DES, SPP1
28estradiol44 24 1110.3DES, IGF2, VIM, MUC1, SYP
29butyrate448.3SPP1, IGF2, VIM, MUC1
30lactate448.3VIM, IGF2, DES, SPP1
31cisplatin44 50 61 1111.3SPP1, IGF2, MUC1, SYP
32heparin44 28 24 1111.1SPP1, DES, IGF2, VIM
33arginine448.1SPP1, DES, IGF2, SMARCA4, VIM
34agar448.0SPP1, IGF2, SMARCA4, VIM, MUC1
35glycogen44 249.0DES, IGF2, VIM, MUC1, ACTC1, SYP
36h2o2448.0SPP1, DES, IGF2, VIM, SYP
37actinomycin d448.0MUC1, VIM, IGF2, DES, SPP1
38glucose447.8SPP1, DES, IGF2, SMARCA4, MUC1, ACTC1
39lipid447.7SYP, MUC1, VIM, SMARCA4, SPP1
40dexamethasone44 50 28 1110.6SPP1, IGF2, VIM, MUC1, ACTC1, SYP
41serine447.4SPP1, DES, IGF2, VIM, MUC1, SYP
42tyrosine447.4SPP1, DES, IGF2, SMARCA4, MUC1, ACTC1
43cysteine447.2SPP1, DES, IGF2, SMARCA4, VIM, MUC1
44paraffin447.2SPP1, DES, IGF2, VIM, MUC1, ACTC1
45creatinine447.2SPP1, DES, IGF2, VIM, MUC1, ACTC1
46vegf447.2SPP1, DES, IGF2, VIM, MUC1, ACTC1
47retinoic acid44 248.2SPP1, DES, IGF2, VIM, MUC1, ACTC1
48progesterone44 28 61 24 1110.8SPP1, DES, IGF2, SMARCA4, VIM, MUC1
49testosterone44 61 24 119.8SPP1, DES, IGF2, SMARCA4, VIM, MUC1
50estrogen446.8SPP1, DES, IGF2, SMARCA4, VIM, MUC1

GO Terms for genes affiliated with Rhabdoid Tumor

About this section

Cellular components related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1npBAF complexGO:0715649.9SMARCA4, SMARCB1
2nBAF complexGO:0715659.8SMARCA4, SMARCB1
3SWI/SNF complexGO:0165149.7SMARCA4, SMARCB1
4cell projectionGO:0429959.0VIM, SPP1
5extracellular spaceGO:0056158.1SPP1, IGF2, SMARCA4, ACTC1

Biological processes related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blastocyst hatchingGO:0018359.9SMARCA4, SMARCB1
2positive regulation by host of viral transcriptionGO:0439239.8SMARCB1, SMARCA4
3chromatin remodelingGO:0063389.8SMARCA4, SMARCB1
4nucleosome disassemblyGO:0063379.7SMARCA4, SMARCB1
5muscle filament slidingGO:0300499.2ACTC1, VIM, DES
6osteoblast differentiationGO:0016498.8IGF2, SPP1

Molecular functions related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Tat protein bindingGO:0309579.8SMARCA4, SMARCB1
2p53 bindingGO:0020399.0MUC1, SMARCA4, SMARCB1

Products for genes affiliated with Rhabdoid Tumor

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Rhabdoid Tumor

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet