MCID: RHB017
MIFTS: 38

Rhabdoid Tumor malady

Cancer diseases category

Summaries for Rhabdoid Tumor

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63Wikipedia, 32MalaCards
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Wikipedia:63 Malignant rhabdoid tumour (MRT) is a very aggressive form of tumour originally described as a variant of... more...

MalaCards: Rhabdoid Tumor, also known as rhabdoid sarcoma, is related to atypical teratoid rhabdoid tumor and medulloblastoma. An important gene associated with Rhabdoid Tumor is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Striated Muscle Contraction and Cardiac Progenitor Differentiation. The compounds estrogen and butyrate have been mentioned in the context of this disorder. Affiliated tissues include kidney, and related mouse phenotypes are muscle and respiratory system.

Aliases & Classifications for Rhabdoid Tumor

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

rhabdoid tumor 42 44 60
rhabdoid sarcoma 42


Related Diseases for Rhabdoid Tumor

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17GeneCards, 18GeneDecks
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Diseases related to Rhabdoid Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1atypical teratoid rhabdoid tumor31.6CLDN6, SMARCB1
2medulloblastoma30.8AURKA, SMARCB1, ACTC1, RASSF1, IGF1R, IGF2
3sarcoma30.8ACTC1, MUC1, MYOD1, IGF1R, IGF2, DES
4epithelioid sarcoma30.7VIM, MUC1, SMARCB1
5hepatoblastoma30.3IGF1R, IGF2
6ganglioglioma30.3SYP
7rhabdomyosarcoma30.3ACTC1, MYOD1, IGF1R, IGF2, DES, STIM1
8neuroblastoma30.2SYP
9hemangioma30.2ACTC1
10choroid plexus carcinoma30.2SMARCB1
11fibrous histiocytoma30.2VIM, DES, ACTC1
12kidney rhabdoid cancer30.2SPP1, RASSF1, WT1
13adenocarcinoma30.2VIM, WT1, CTSD, SYP, IGF1R, MUC1
14rhabdoid cancer30.1SMARCB1, RTDR1
15chondrosarcoma30.0MUC1, DES, VIM
16beckwith-wiedemann syndrome30.0IGF1R, IGF2, WT1
17smooth muscle tumor30.0ACTC1, IGF2, DES, VIM
18pleomorphic adenoma30.0VIM, DES, IGF2, MUC1, ACTC1
19leukemia30.0SMARCA4, CTSD, WT1
20meningioma30.0VIM, CTSD, SYP, IGF2, MUC1, SMARCB1
21osteosarcoma30.0BMP1, IGF2, IGF1R, MYOD1, SPP1
22adenoma30.0CTSD, SYP, IGF2, IGF1R, MYOD1, MUC1
23lung adenocarcinoma30.0IGF1R, MUC1, RASSF1, SPP1
24papillary carcinoma30.0ACTC1, MUC1, SYP
25acute leukemia30.0SMARCB1, WT1
26rhabdoid tumors, somatic10.6
27primitive neuroectodermal tumor10.5
28cerebritis10.4
29cervicitis10.4
30rhabdoid tumor predisposition syndrome 210.3
31rhabdoid tumor predisposition syndrome 110.3
32choroiditis10.2
33thyroiditis10.2
34hypercalcemia10.1
35childhood medulloblastoma10.1
36histiocytoma10.1
37meningitis10.1
38brain sarcoma10.1
39cerebral primitive neuroectodermal tumor10.0
40neurofibromatosis10.0
41renal wilms' tumor10.0
42junctional epidermolysis bullosa10.0
43canavan disease10.0
44supratentorial primitive neuroectodermal tumor10.0
45ectomesenchymoma10.0
46mutism10.0
47differentiating neuroblastoma10.0
48nodular medulloblastoma10.0
49pleomorphic xanthoastrocytoma10.0
50hydranencephaly10.0

Graphical network of the top 20 diseases related to Rhabdoid Tumor:



Diseases related to rhabdoid tumor

Clinical Features for Rhabdoid Tumor

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Drugs & Therapeutics for Rhabdoid Tumor

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Rhabdoid Tumor

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Anatomical Context for Rhabdoid Tumor

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32MalaCards
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MalaCards organs/tissues related to Rhabdoid Tumor:

32
Kidney

Animal Models for Rhabdoid Tumor or affiliated genes

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36MGI
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Publications for Rhabdoid Tumor

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Genetic Variations for Rhabdoid Tumor

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Expression for genes affiliated with Rhabdoid Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdoid Tumor

Search GEO for disease gene expression data for Rhabdoid Tumor.

Pathways for genes affiliated with Rhabdoid Tumor

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Sources:
37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 51QIAGEN
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Compounds for genes affiliated with Rhabdoid Tumor

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44Novoseek, 24HMDB, 49PharmGKB, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR
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Compounds related to Rhabdoid Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9MYOD1
2butyrate4410.8MYOD1
3s 1004410.8VIM, ACTC1, MUC1, SYP, DES
4reticulin4410.8VIM, DES, MUC1, ACTC1, SYP
5mucicarmine4410.8ACTC1, MUC1, SYP, VIM, DES
6hematoxylin4410.7DES, SYP, MUC1, ACTC1, VIM
7b 7234410.7ACTC1, SYP, MUC1, WT1, DES, VIM
8orcein4410.7VIM, DES, ACTC1
9formaldehyde44 2411.7VIM, CTSD, DES, MUC1, ACTC1, SYP
10progestin4410.7MUC1, CTSD, DES, IGF1R, IGF2, VIM
11glucose4410.7MUC1, ACTC1, CTSD, SMARCA4, IGF2, IGF1R
12glycogen44 2411.7IGF2, VIM, SYP, DES, ACTC1, IGF1R
13azathioprine44 49 2 1113.7IGF2, RASSF1, MYOD1, DES, VIM
14hyaluronic acid44 2411.6WT1, IGF1R, SPP1, MUC1, VIM, CTSD
15steroid4410.6ACTC1, SYP, SMARCA4, MYOD1, WT1, CTSD
16agar4410.6IGF1R, MUC1, RASSF1, SPP1, SMARCA4, CTSD
17creatinine4410.6SPP1, ACTC1, IGF1R, IGF2, SYP, CTSD
18estradiol44 11 2412.6DES, CTSD, VIM, SYP, IGF2, IGF1R
19adriamycin4410.6CTSD, IGF1R, MUC1, DES, VIM
20actinomycin d4410.6MUC1, VIM, DES, IGF2, MYOD1, SPP1
21etoposide44 49 59 1113.6WT1, SYP, IGF2, IGF1R, VIM, CTSD
22ribonucleic acid4410.6IGF1R, WT1, IGF2, ACTC1, MUC1, SPP1
23gold4410.6IGF1R, SYP, DES, CTSD, MUC1
24dihydrotestosterone44 28 11 2413.6IGF1R, IGF2, DES, VIM, MUC1
25lysine4410.6WT1, CTSD, MYOD1, DES, SMARCA4, IGF1R
26cisplatin44 49 59 1113.6MUC1, SPP1, IGF1R, IGF2, CTSD, RASSF1
2712-o-tetradecanoylphorbol 13-acetate4410.6VIM, CTSD, MUC1, MYOD1, DES, WT1
282-methoxyethanol4410.6ACTC1, VIM, IGF2
29progesterone44 59 28 11 2414.6SPP1, ACTC1, MUC1, IGF2, SYP, DES
30arginine4410.6SMARCA4, VIM, IGF2, IGF1R, SPP1, BMP1
31oligonucleotide4410.6VIM, IGF2, SPP1, WT1, IGF1R, MYOD1
32paraffin4410.5SPP1, VIM, WT1, CTSD, SYP, IGF2
33imatinib44 49 1112.5ACTC1, IGF2, WT1, IGF1R, DES
34vegf4410.5SPP1, ACTC1, MUC1, MYOD1, IGF1R, IGF2
35testosterone44 59 11 2413.5MYOD1, MUC1, ACTC1, SPP1, CTSD, SMARCA4
36cysteine4410.5VIM, SPP1, MUC1, MYOD1, SMARCA4, IGF1R
37threonine4410.5SPP1, WT1, MUC1, RASSF1, MYOD1, IGF1R
38alanine4410.5RASSF1, MYOD1, VIM, IGF1R, IGF2, BMP1
39retinoic acid44 2411.5ACTC1, CTSD, MUC1, MYOD1, SPP1, IGF1R
40h2o24410.5VIM, SPP1, SYP, DES, CTSD, IGF2
41forskolin44 49 1112.4MUC1, WT1, SYP, IGF2, IGF1R, VIM
42serine4410.4IGF1R, VIM, AURKA, WT1, BMP1, DES
434-hydroxytamoxifen4410.4IGF2, IGF1R, CTSD, VIM
44calcitriol44 59 11 2413.4CTSD, IGF2, IGF1R, WT1, SPP1
45tyrosine4410.4SPP1, SMARCA4, WT1, DES, SYP, IGF2
46calcium44 49 11 2413.3CTSD, INA, MYOD1, STIM1, IGF1R, SPP1
47chloramphenicol44 2 1112.3WT1, VIM, IGF2, MUC1, MYOD1
48dexamethasone44 49 28 1113.3IGF2, IGF1R, SPP1
49glutamine4410.3CTSD, WT1, VIM, SYP, IGF2, IGF1R
50lactate4410.0SPP1, IGF1R, VIM, IGF2, DES, CTSD

GO Terms for genes affiliated with Rhabdoid Tumor

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16Gene Ontology
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Cellular components related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nBAF complexGO:07156510.4SMARCB1, SMARCA4
2npBAF complexGO:07156410.3SMARCB1, SMARCA4
3nuclear chromatinGO:00079010.1SMARCA4, MUC1, MYOD1

Biological processes related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:03004910.5ACTC1, DES, VIM
2blastocyst hatchingGO:00183510.4SMARCB1, SMARCA4
3extracellular matrix organizationGO:03019810.3SMARCA4, SPP1, BMP1, CTSD
4regulation of transcription from RNA polymerase II promoterGO:00635710.2WT1, MYOD1, SMARCA4, SMARCB1
5positive regulation by host of viral transcriptionGO:04392310.1SMARCB1, SMARCA4

Molecular functions related to Rhabdoid Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1p53 bindingGO:00203910.4MUC1, SMARCA4, SMARCB1
2structural constituent of cytoskeletonGO:00520010.4INA, DES, VIM
3Tat protein bindingGO:03095710.3SMARCB1, SMARCA4
4identical protein bindingGO:04280210.3RASSF1, CLDN6, IGF1R, SYP, DES, STIM1
5protein bindingGO:0055159.7VIM, AURKA, WT1, CTSD, STIM1, DES

Products for genes affiliated with Rhabdoid Tumor

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  • Antibodies
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Sources for Rhabdoid Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet