Rhabdoid Tumors malady

Wikipedia: Malignant rhabdoid tumour (MRT) is a very aggressive form of tumour originally described as a variant of...⁴⁴ more...

MalaCards: Rhabdoid Tumors, also known as rhabdoid tumor, is related to atypical teratoid rhabdoid tumor and epithelioid sarcoma. An important gene associated with Rhabdoid Tumors is SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), and among its related pathways are Signal transduction_PTEN pathway and CDO in myogenesis. The compounds h2o2 and genistein have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and kidney, and related mouse phenotypes are growth/size and craniofacial.

rhabdoid tumors 7 33 rhabdoid tumor 30 32 43

Diseases related to rhabdoid tumors by text searches and GeneDecks gene sharing:

(show top 50)    (show all 722)

id	Related Disease	Score	Top Affiliating Genes
1	atypical teratoid rhabdoid tumor	36.1	VIM, RASSF1, CLDN6, MUC1, CDH2, INA
2	epithelioid sarcoma	31.8	VIM, MUC1, SMARCB1, KRT8, KRT1
3	choroid plexus carcinoma	31.2	TP53, SMARCA4, SMARCB1, SYP
4	rhabdoid cancer	29.9	VIM, RAB36, SMARCB1, DES, RTDR1
5	pleomorphic xanthoastrocytoma	29.5	CDKN2A, TP53, SMARCB1, GFAP, SYP
6	beckwith-wiedemann syndrome	29.4	MYOD1, CDKN1C, IGF1R, IGF2, TP53, CTNNB1
7	childhood medulloblastoma	29.3	MYC, MYCN, ERBB4
8	ganglioglioma	28.9	MYCN, CHGA, S100B, ENO2, TP53, SMARCB1
9	pleomorphic adenoma	28.5	VIM, MUC1, S100B, IGF2, ERBB2, ACTC1
10	choroiditis	27.6	NCAM1, VIM, MYC, RASSF1, PAX3, MUC1
11	neuroectodermal tumors	26.9	NCAM1, VIM, MYC, MYCN, MYOG, RASSF1
12	hypercalcemia	26.1	VIM, CHGA, IL2, IL3, CCND1, ALPP
13	medulloblastoma	22.5	PIK3CA, NCAM1, REST, VIM, MYC, MYCN
14	meningioma	21.5	NCAM1, VIM, MYC, MYCN, RASSF1, BCR
15	rhabdomyosarcoma	21.0	NCAM1, VIM, MYC, MYCN, MYOG, MYF5
16	adenoma	16.7	PIK3CA, NCAM1, VIM, MYC, MYOD1, RASSF1
17	sarcoma	16.7	PIK3CA, NCAM1, VIM, MYC, MYCN, MYOG
18	neuroblastoma	16.5	PIK3CA, NCAM1, REST, VIM, MYC, MYCN
19	carcinoma	14.8	PIK3CA, NCAM1, REST, VIM, MYC, MYCN
20	epithelioid leiomyosarcoma	14.0	VIM, ACTC1, DES
21	glomangiomyoma	14.0	VIM, ACTC1, DES
22	infantile myofibromatosis	14.0	VIM, ACTC1, DES
23	rectum sarcomatoid carcinoma	13.9	VIM, MUC1, ACTC1, DES
24	myofibroma	13.9	VIM, ACTC1, DES
25	mesenchymal chondrosarcoma	13.9	VIM, MUC1, DES
26	childhood mediastinal neurogenic tumor	13.9	IGF1R, WT1, DES
27	neurilemmoma	13.9	VIM, SMARCB1, GFAP, DES
28	desmoplastic small round cell tumor	13.9	MUC1, WT1, DES
29	metanephric adenoma	13.9	VIM, MUC1, WT1, DES
30	cerebrum cancer	13.9	TP53, SMARCB1, GFAP
31	congenital mesoblastic nephroma	13.9	VIM, IGF2, SMARCB1, WT1
32	osteoblastoma	13.9	VIM, MUC1, TP53
33	cystic nephroma	13.9	VIM, MUC1, WT1, ACTC1, DES
34	sarcomatoid mesothelioma	13.9	VIM, MUC1, WT1, ACTC1, DES
35	benign metastasizing leiomyoma	13.9	VIM, MIR221, ACTC1, DES
36	pilomyxoid astrocytoma	13.9	BCR, GFAP, SYP
37	spindle cell lipoma	13.9	VIM, ACTC1, DES
38	malignant mesenchymoma	13.9	MYOG, MYOD1, DES
39	endometrial stromal tumor	13.9	VIM, CCND1, CTNNB1, DES
40	mucinous cystadenocarcinoma	13.9	VIM, MUC1, PTPRC, ACTC1
41	adenomatoid tumor	13.9	VIM, MUC1, WT1, DES
42	serous cystadenoma	13.9	VIM, MUC1, TP53, ACTC1, SYP
43	binswanger's disease	13.9	ACTC1, GFAP, SYP
44	osteofibrous dysplasia	13.9	VIM, MUC1, SPP1, KRT1
45	pulmonary blastoma	13.9	VIM, TP53, CTNNB1, SYP
46	cerebellar liponeurocytoma	13.8	TP53, CTNNB1, GFAP, SYP
47	breast metaplastic carcinoma	13.8	VIM, TP53, CTNNB1, DES
48	ossifying fibroma	13.8	VIM, KRT1, ACTC1, DES
49	pseudosarcomatous fibromatosis	13.8	VIM, MYOG, CTNNB1, ACTC1, DES
50	malignant giant cell tumor of soft parts	13.8	S100B, ACTC1, DES

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to rhabdoid tumors:

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MGI Mouse Phenotypes related to rhabdoid tumors:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	IGF2, KRT8, EGF, ABL1, ACTC1, GFAP
2	craniofacial phenotype	MP:0005382	10.1	IGF1R, CDKN1C, PAX3, MYCN
3	respiratory system phenotype	MP:0005388	9.6	MYCN, MYOG, MYF5, MYF6, MYOD1, PAX3
4	endocrine/exocrine gland phenotype	MP:0005379	9.0	PAX3, CDKN1C, IL2, ERBB4, CASP8, WT1
5	liver/biliary system phenotype	MP:0005370	8.9	SMARCB1, SMARCA4, PTPRC, TP53, ID1, IL2
6	limbs/digits/tail phenotype	MP:0005371	8.9	SMARCA4, CTNNB1, PTHLH, ERBB2, IGF1R, CDKN1C
7	other phenotype	MP:0005395	8.6	COL18A1, SPP1, PTGS2, IL2, CDKN2A, MYF5
8	hematopoietic system phenotype	MP:0005397	8.6	MYCN, PAX3, CDKN1A, IL3, CCND1, IGF2
9	no phenotypic analysis	MP:0003012	8.5	CTNNB1, PTGS2, MUC1, TNFRSF10B, TP53, MYF6
10	adipose tissue phenotype	MP:0005375	7.8	MYC, MYOG, MYF5, PIK3CA, MYOD1, CDKN1A
11	integument phenotype	MP:0010771	6.6	MYC, MYOG, PAX3, MUC1, S100B, CDKN1A
12	vision/eye phenotype	MP:0005391	6.3	STIM1, CCND1, IGF2, ID1, AIFM1, TP53
13	skeleton phenotype	MP:0005390	6.0	MYC, MYCN, MYOG, PTGS2, PTHLH, PTPRC
14	tumorigenesis	MP:0002006	5.6	ERBB2, TP53, TNFRSF10B, TNFSF10, PTGS2, PTPRC
15	muscle phenotype	MP:0005369	4.6	PIK3CA, VIM, MYC, MYCN, MYOG, ERBB2
16	cardiovascular system phenotype	MP:0005385	3.1	ID1, EZH2, CASP8, CALCA, AKT1, AIFM1
17	mortality/aging	MP:0010768	INF	AKT1, AIFM1, ERBB4, TP53, TNFSF10, CTSD
18	normal phenotype	MP:0002873	INF	MYF5, MYOG, PTPRC, MYOD1, SYP, GFAP
19	renal/urinary system phenotype	MP:0005367	INF	WT1, CXCR4, MYH11, CDKN1C, ID1, PTPRC
20	cellular phenotype	MP:0005384	INF	TP53, CXCR4, STIM1, TNFRSF10B, TNFSF10, PTGS2
21	embryogenesis phenotype	MP:0005380	INF	CDH2, ID1, , EZH2, AIFM1, ERBB4
22	reproductive system phenotype	MP:0005389	INF	MYOD1, PAX3, CDKN1C, CCND1, , AKT1
23	immune system phenotype	MP:0005387	INF	CDKN1C, IL2, CCND1, IGF1R, HSP90AA1, EZH2
24	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, NCAM1, VIM, MYCN, SPP1, MYF5
25	digestive/alimentary phenotype	MP:0005381	INF	, MUC1, CDKN1A, CDKN2A, CDKN1C, IGF1R
26	nervous system phenotype	MP:0003631	INF	, CDKN1A, CDH2, CDKN1C, CCND1, IGF2
27	homeostasis/metabolism phenotype	MP:0005376	INF	MYF6, PTGS2, PTHLH, PTPRC, SPP1, CTSD

Articles related to rhabdoid tumors:

(show top 50)    (show all 111)

id	Title	Authors	Year	Affiliating Genes
1	Clinical and molecular features in patients with atyp ical teratoid rhabdoid tumor or malignant rhabdoid tumor. (19902524)	Kordes U.... Schneppenheim R.	2010	SMARCB1
2	Disabling c-Myc in childhood medulloblastoma and atyp ical teratoid/rhabdoid tumor cells by the potent G-quadruplex interactive agent S2T1-6OTD. (20053783)	Shalaby T.... Grotzer M.	2010	MYC
3	The tyrosine kinase c-Abl promotes proliferation and is expressed in atypical teratoid and malignant rhabdoid tumors. (20629032)	Koos B.... Hasselblatt M.	2010	ABL1
4	Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets. (20212451)	Gadd S.... Perlman E.J.	2010	COL18A1, SMARCB1
5	Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation. (18821579)	Watanabe M.... Nakahata T.	2009	HDAC9, AIFM1
6	Case report of extrarenal rhabdoid tumor of pelvic re troperitoneum molecular profile of angiogenesis and its implication in new trea tment strategy. (19276648)	Cai G.... Cai S.	2009	ERBB2
7	Rare intraparenchymal choroid plexus carcinoma resemb ling atypical teratoid/rhabdoid tumor diagnosed by immunostaining for INI1 prot ein. (19795969)	Stevens E.A.... Ellis T.L.	2009	SMARCB1
8	Establishment of atypical-teratoid/rhabdoid tumor (AT/RT) cell cultures from disseminated CSF cells: a model to elucidate biology and potential targeted therapeutics. (18651103)	Narendran A.... Strother D.	2008	ERBB4, HSP90AA1
9	Rhabdoid tumor growth is inhibited by flavopiridol. (18223228)	Smith M.E.... Kalpana G.V.	2008	CCND1, CDKN1A
10	The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors. (17922027)	Caramel J.... Delattre O.	2008	SMARCB1
11	Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma. (17431546)	Chacko G.... Perry A.	2007	SMARCB1
12	Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature. (17377740)	Zarovnaya E.L.... Rhodes C.H.	2007	SMARCB1
13	Mutation of the INI1 gene in composite rhabdoid tumor of the endometrium. (17376508)	Donner L.R.... Biegel J.A.	2007	SMARCB1
14	Epigenetic repression of RASSF1A but not CASP8 in supratentorial PNET (sPNET) and atypical teratoid/rhabdoid tumors (AT/RT) of childhood. (16186793)	Muhlisch J.... Fruhwald M.C.	2006	RASSF1
15	Atypical teratoid/rhabdoid tumor arising from the spinal cord--case report and review of the literature. (16550741)	Tanizaki Y.... Fujii K.	2006	ACTC1
16	Immunohistochemical analysis of INI1 protein in malignant pediatric CNS tumors: Lack of INI1 in atypical teratoid/rhabdoid tumors and in a fraction of primitive neuroectodermal tumors without rhabdoid phenotype. (17063089)	Haberler C.... Hainfellner J.A.	2006	SMARCB1
17	Non-linkage of familial rhabdoid tumors to SMARCB1 implies a second locus for the rhabdoid tumor predisposition syndrome. (16206192)	Fruhwald M.C.... Vormoor J.	2006	SMARCB1
18	Targeting cyclin D1, a downstream effector of INI1/hS NF5, in rhabdoid tumors. (16302003)	Alarcon-Vargas D.... Kalpana G.V.	2006	CCND1
19	Elevation of plasma and cerebrospinal fluid osteopontin levels in patients with atypical teratoid/rhabdoid tumor. (15842057)	Kao C.L.... Wong T.T.	2005	SPP1
20	INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma. (15892296)	Judkins A.R.... Biegel J.A.	2005	SMARCB1
21	Establishment of a cell line from a malignant rhabdoid tumor of the liver lacking the function of two tumor suppressor genes, hSNF5/INI1 and p16. (15796965)	Kuroda H.... Sugimoto T.	2005	MYH11
22	Increased expression of osteopontin gene in atypical teratoid/rhabdoid tumor of the central nervous system. (15776015)	Kao C.L.... Wong T.T.	2005	SPP1
23	Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss. (16099835)	Tsikitis M.... Kalpana G.V.	2005	SMARCB1
24	Immunohistochemical analysis of hSNF5/INI1 distinguishes renal and extra-renal malignant rhabdoid tumors from other pediatric soft tissue tumors. (15489652)	Hoot A.C.... Biegel J.A.	2004	SMARCB1
25	Malignant rhabdoid tumor arising from a pleomorphic adenoma. (15185263)	Fung K.M.... Luna M.A.	2004	VIM
26	P16INK4a is required for hSNF5 chromatin remodeler-induced cellular senescence in malignant rhabdoid tumor cells. (14604992)	Oruetxebarria I.... Verrijzer C.P.	2004	CDKN2A, SMARCB1
27	Double immunolabeling of central nervous system atypi cal teratoid/rhabdoid tumors. (15105808)	Bouffard J.P.... Rorke L.B.	2004	GFAP, ACTC1
28	Alpha-internexin expression in medulloblastomas and atypical teratoid-rhabdoid tumors. (14531545)	Kaya B.... Rushing E.J.	2003	SYP, INA
29	Expression of pericyte, mesangium and muscle markers in malignant rhabdoid tumor cell lines: differentiation-induction using 5-azacytidine. (14662021)	Kato H.... Sugita K.	2003	MYOD1, MYOG, MYF5
30	INI1 expression induces cell cycle arrest and markers of senescence in malignant rhabdoid tumor cells. (12548550)	Reincke B.S.... Wright C.F.	2003	SMARCB1
31	Atypical teratoid/rhabdoid tumors and choroid plexus tumors: when genetics 'surprise' pathology. (12946029)	Gessi M.... Pietsch T.	2003	SMARCB1
32	Malignant rhabdoid tumor shows a unique neural differentiation as distinct from neuroblastoma. (12708472)	Higashino K.... Takeuchi Y.	2003	CHGA, REST
33	Alterations of the hSNF5/INI1 gene in central nervous system atypical teratoid/rhabdoid tumors and renal and extrarenal rhabdoid tumors. (12429635)	Biegel J.A.... Rorke L.B.	2002	SMARCB1
34	Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid tumor: a possible association with intracytoplasmic inclusion body formation. (11850543)	Shiratsuchi H.... Tsuneyoshi M.	2002	KRT8
35	The role of INI1 and the SWI/SNF complex in the development of rhabdoid tumors: meeting summary from the workshop on childhood atypical teratoid/rhabdoid tumors. (11782395)	Biegel J.A.... Smith M.	2002	SMARCB1
36	Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors. (11921280)	Uno K.... Hayashi Y.	2002	SMARCB1
37	Subcellular distribution of cytokeratin and vimentin in malignant rhabdoid tumor: three-dimensional imaging with confocal laser scanning microscopy and double immunofluorescence. (11557780)	Itakura E.... Tsuneyoshi M.	2001	VIM
38	The autocrine loop of epidermal growth factor receptor-epidermal growth factor / transforming growth factor-alpha in malignant rhabdoid tumor cell lines: heterogeneity of autocrine mechanism in TTC549. (11267936)	Narita T.... Ohta S.	2001	EGF, TGFA
39	Haploinsufficiency of Snf5 (integrase interactor 1) predisposes to malignant rhabdoid tumors in mice. (11095756)	Roberts C.W.... Orkin S.H.	2000	SMARCB1
40	Isolation of genes from the rhabdoid tumor deletion region in chromosome band 22q11.2. (10607907)	Zhou J.-Y.... Biegel J.A.	2000	RAB36, RTDR1
41	Germline INI1 mutation in a patient with a central nervous system atypical teratoid tumor and renal rhabdoid tumor. (10738300)	Biegel J.A.... Rorke L.B.	2000	SMARCB1
42	Inv(11)(p13p15) and myf-3(MyoD1) in a malignant extrarenal rhabdoid tumor of a premature newborn. (11004236)	Staehelin F.... KA1hne T.	2000	PAX3, MYOD1
43	Malignant rhabdoid-tumor cell line showing neural and smooth-muscle-cell phenotypes. (10417765)	Sugimoto T.... Sawada T.	1999	MYH11
44	Malignant rhabdoid tumor of the orbit. (9488282)	GA1ndA1z K.... Klombers L.	1998	VIM
45	GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development. (9377559)	Sabbioni S.... Negrini M.	1997	STIM1
46	Gene expression of malignant rhabdoid tumor cell lines by reverse transcriptase-polymerase chain reaction. (9559292)	Suzuki A.... Shimada M.	1997	S100B, NCAM1, IL3
47	Immunohistochemistry of primary central nervous system malignant rhabdoid tumors: report of five cases and review of the literature. (8781656)	Behring B.... Kretzschmar H.A.	1996	VIM
48	Rhabdoid tumor of the kidney with humoral hypercalcemia and parathyroid hormone-related protein production. (7990762)	Papadakis V.... Levine L.	1995	CALCA, PTHLH
49	Malignant rhabdoid tumor. A study with two established cell lines. (8385567)	Ota S.... Shimada H.	1993	MYC, MYCN
50	Malignant rhabdoid tumor of the liver. A distinct clinicopathologic entity. (1700599)	Hunt S.J.... Anderson W.D.	1990	VIM

Genes related to rhabdoid tumors according to GeneCards:

(show top 50)    (show all 71)

id	Symbol	Description	Score	GeneCards Section Context
1	SMARCB1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	11.1	Summaries, Aliases & Descriptions, Publications, Functions
2	RTDR1	rhabdoid tumor deletion region gene 1	11.1	Orthologs, Summaries, Transcripts, Expressions (show all 6 sections) Publications, Aliases & Descriptions
3	SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	11.1	Publications, Summaries
4	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
5	DES	desmin	11.0	Publications
6	SYP	synaptophysin	11.0	Publications
7	MUC1	mucin 1, cell surface associated	11.0	Publications
8	VIM	vimentin	11.0	Publications
9	SPP1	secreted phosphoprotein 1	11.0	Publications
10	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
11	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Publications
12	CLDN6	claudin 6	11.0	Publications
13	INA	internexin neuronal intermediate filament protein, alpha	11.0	Publications
14	MYOD1	myogenic differentiation 1	11.0	Publications
15	RASSF1	Ras association (RalGDS/AF-6) domain family member 1	11.0	Publications
16	STIM1	stromal interaction molecule 1	11.0	Publications, Functions
17	CTSD	cathepsin D	11.0	Publications
18	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	11.0	Publications
19	GFAP	glial fibrillary acidic protein	11.0	Publications
20	PTPRC	protein tyrosine phosphatase, receptor type, C	11.0	Publications
21	HSP90AA1	heat shock protein 90kDa alpha (cytosolic), class A member 1	11.0	Publications
22	WT1	Wilms tumor 1	11.0	Publications
23	ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)	11.0	Publications
24	CTNNB1	catenin (cadherin-associated protein), beta 1, 88kDa	11.0	Publications
25	CCND1	cyclin D1	11.0	Publications
26	TP53	tumor protein p53	11.0	Publications
27	RAB36	RAB36, member RAS oncogene family	11.0	Publications, Functions
28	MIR221	microRNA 221	11.0	Publications
29	MIR222	microRNA 222	11.0	Publications
30	FXYD5	FXYD domain containing ion transport regulator 5	11.0	Publications
31	MYF5	myogenic factor 5	11.0	Publications
32	MYF6	myogenic factor 6 (herculin)	11.0	Publications
33	REST	RE1-silencing transcription factor	11.0	Publications
34	CDKN1C	cyclin-dependent kinase inhibitor 1C (p57, Kip2)	11.0	Publications
35	TNFRSF10C	tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain	11.0	Publications
36	SERPINB7	serpin peptidase inhibitor, clade B (ovalbumin), member 7	11.0	Publications
37	KRT1	keratin 1	11.0	Publications
38	ID1	inhibitor of DNA binding 1, dominant negative helix-loop-helix protein	11.0	Publications
39	MYOG	myogenin (myogenic factor 4)	11.0	Publications
40	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
41	AIFM1	apoptosis-inducing factor, mitochondrion-associated, 1	11.0	Publications
42	TNFRSF10A	tumor necrosis factor receptor superfamily, member 10a	11.0	Publications
43	TNFRSF10D	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	11.0	Publications
44	COL18A1	collagen, type XVIII, alpha 1	11.0	Publications
45	PAX3	paired box 3	11.0	Publications
46	EZH2	enhancer of zeste homolog 2 (Drosophila)	11.0	Publications
47	KRT8	keratin 8	11.0	Publications
48	S100B	S100 calcium binding protein B	11.0	Publications
49	MYH11	myosin, heavy chain 11, smooth muscle	11.0	Publications
50	CHGA	chromogranin A (parathyroid secretory protein 1)	11.0	Publications

Pathways related to rhabdoid tumors according to GeneDecks:

(show top 50)    (show all 116)

id	Pathway	Score	Top Affiliating Genes
1	Signal transduction_PTEN pathway41	10.7	IGF1R
2	CDO in myogenesis38	10.4	CTNNB1, MYOG, MYF5, MYF6, CDH2, MYOD1
3	Glioblastoma Multiforme36	10.2	TP53, AKT1, IGF1R, CDKN1A, IGF2
4	TRAIL Pathway36	9.5	TNFRSF10A, TNFSF10, CASP8, TNFRSF10B, TNFRSF10C, TNFRSF10D
5	Apoptosis through Death Receptors36	9.4	TNFRSF10C, TNFRSF10B, TNFSF10, CASP8, TP53, TNFRSF10A
6	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	9.4	HDAC9, AKT1, MYOD1, MYF6, MYOG, PIK3CA
7	Signal transduction_AKT signaling41	9.4	MYC, TP53, HSP90AA1, AKT1, IGF1R, CCND1
8	Signal transduction PTEN pathway10	9.3	EGF, CDKN1A, PIK3CA, IGF1R, AKT1
9	Apoptosis Signaling Pathways37	9.3	TNFRSF10B, HSP90AA1, TNFSF10, TNFRSF10A, TP53, AIFM1
10	14-3-3 Induced Intracellular Signaling36	9.3	IGF1R, IL3, ERBB4, ERBB2, AKT1
11	p53 Signaling36	9.2	AKT1, CASP8, ABL1, TNFRSF10B, TP53, CDKN1A
12	Development ERBB-family signaling10	9.2	ERBB2, TGFA, MYC, ERBB4, EGF
13	Development_ERBB-family signaling41	9.1	TGFA, EGF, ERBB4, ERBB2, PIK3CA
14	Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis41	9.0	IGF1R, HDAC9, CDKN1A, MYF6, MYOG, PIK3CA
15	Akt Signaling36	8.9	AKT1, HSP90AA1, IGF1R, CCND1, IL2, TNFRSF10A
16	Melanoma20	8.9	IGF1R, TP53, EGF, AKT1, CCND1, CDKN2A
17	Apoptosis and Autophagy3	8.8	AIFM1, CTSD, TNFSF10, TNFRSF10D, TNFRSF10C, TNFRSF10B
18	Glioma20	8.8	PIK3CA, CDKN1A, CDKN2A, AKT1, IGF1R, CCND1
19	Non-small cell lung cancer20	8.8	PIK3CA, RASSF1, CDKN2A, AKT1, TGFA, ERBB2
20	Bladder cancer20	8.7	CCND1, CDKN2A, CDKN1A, EGF, TP53, ERBB2
21	Apoptosis20	8.7	PIK3CA, TNFSF10, TNFRSF10D, TNFRSF10C, TNFRSF10B, TP53
22	Endometrial cancer20	8.7	AKT1, PIK3CA, CTNNB1, EGF, CCND1, TP53
23	Telomerase Components in Cell Signaling36	8.6	HSP90AA1, IL2, MYC, IL3, IGF2, AKT1
24	Measles20	8.5	IL2, AKT1, TNFRSF10D, TNFRSF10C, TNFRSF10B, TNFRSF10A
25	JNK Pathway36	8.5	IL3, IL2, TNFRSF10C, TNFSF10, EGF, TNFRSF10D
26	Prostate cancer20	8.4	IGF1R, PIK3CA, TGFA, EGF, CTNNB1, TP53
27	Rho Family GTPases36	8.3	VIM, GFAP, IL3, DES, TGFA, IGF1R
28	Apoptotic Pathways in Synovial Fibroblasts36	8.1	CASP8, IGF2, EGF, IL3, IL2, AKT1
29	ErbB signaling pathway20	8.1	PIK3CA, TGFA, CDKN1A, AKT1, ERBB2, ERBB4
30	ILK Signaling36	8.1	IGF2, ERBB4, AKT1, IGF1R, IL3, CDH2
31	Glucocorticoid Receptor Signaling36	8.0	TNFRSF10A, TNFSF10, IL2, IL3, TNFRSF10B, CDKN1A
32	TGF-Beta Pathway36	8.0	IL3, TGFA, EGF, TNFSF10, TNFRSF10D, IL2
33	Mitochondrial Apoptosis36	7.9	CDKN2A, IL3, IGF1R, IL2, AKT1, TP53
34	STAT3 Pathway36	7.9	MYC, CDKN1A, IL2, IL3, TNFRSF10A, TNFRSF10B
35	p53 Mediated Apoptosis36	7.9	TNFRSF10B, TNFSF10, EGF, TGFA, TP53, AKT1
36	GSK3 Signaling36	7.7	IL2, EGF, TGFA, CTNNB1, ERBB2, CDH2
37	Epithelial Adherens Junctions36	7.7	IL2, MYH11, CDH2, TGFA, EGF, CTNNB1
38	Cellular Apoptosis Pathway36	7.7	CDKN2A, IL2, IL3, IGF1R, IGF2, TGFA
39	Antioxidant Action of Vitamin-C36	7.7	TNFRSF10B, TNFRSF10A, IGF2, CXCR4, IGF1R, IL3
40	eNOS Signaling36	7.6	IGF1R, IL3, IL2, IGF2, HSP90AA1, CASP8
41	MAPK Signaling36	7.4	ERBB4, IGF2, IGF1R, IL3, IL2, MYC
42	Tec Kinases Signaling36	7.3	TGFA, IL2, IL3, IGF2, IGF1R, ERBB4
43	p38 Signaling36	7.3	EGF, TGFA, TNFSF10, TNFRSF10D, TNFRSF10C, TNFRSF10B
44	Estrogen Pathway36	7.2	IL2, HDAC9, IL3, TGFA, CCND1, IGF1R
45	ERK Signaling36	7.0	TGFA, EGF, SPP1, TNFSF10, COL18A1, ERBB2
46	Pancreatic Adenocarcinoma36	6.9	HSP90AA1, AKT1, ERBB4, ERBB2, PTGS2, IGF2
47	JAK-STAT Pathway36	6.8	TNFRSF10D, TNFSF10, IL2, TGFA, CXCR4, MYC
48	Molecular Mechanisms of Cancer36	6.3	TNFRSF10B, TNFRSF10A, CDKN1A, TP53, ERBB4, AKT1
49	Chronic myeloid leukemia20	INF	PIK3CA, MYC, , CDKN1A, CDKN2A, CCND1
50	Pathways in cancer20	INF	RASSF1, TP53, CTNNB1, EGF, ABL1, TGFA

Compounds related to rhabdoid tumors according to GeneDecks:

(show top 50)    (show all 295)

id	Compound	Score	Top Affiliating Genes
1	h2o232	INF	DES, SYP, PTPRC, TNFRSF10B, AIFM1,
2	genistein32 9 18 9	INF	CTSD, MYCN, MYC, VIM, PIK3CA,
3	serine32	INF	MYOG, MYCN, MYC, VIM, SERPINB7, NCAM1
4	thymidine32 18	INF	PIK3CA, TNFRSF10B, TP53, , IGF2, IGF1R
5	pd 98,05932	INF	HDAC9, CXCR4, TGFA, GFAP, EGF, CTNNB1
6	s 10032	10.1	MUC1, CHGA, VIM, S100B, ENO2, ACTC1
7	vincristine32 34 9 9	12.9	PTHLH, CALCA, MYCN, NCAM1
8	threonine32	9.8	KRT1, KRT8, WT1, CASP8, MYOD1
9	4-hydroxytamoxifen32	9.2	EGF, ERBB2, HSP90AA1, CDH2, S100B, MYC
10	hematoxylin32	9.0	ACTC1, KRT1, KRT8, PTPRC, ENO2, CDKN2A
11	formaldehyde32 18	9.5	VIM, CHGA, MUC1, S100B, HDAC9, DES
12	12-o-tetradecanoylphorbol 13-acetate32	8.3	TGFA, EGF, KRT1, CTSD, PTPRC, PTHLH
13	rapamycin32 42	9.1	EGF, AIFM1, AKT1, HSP90AA1, IGF2, IGF1R
14	n acetylcysteine32	8.1	HDAC9, CTNNB1, PTPRC, TNFSF10, TNFRSF10B, TP53
15	suberoylanilide hydroxamic acid32	7.9	HDAC9, TNFSF10, TNFRSF10B, TNFRSF10A, TP53, ERBB2
16	trastuzumab32 34 9 9	10.8	ERBB4, HSP90AA1, IGF1R, CCND1, IL2, MUC1
17	mg 13232 42	8.8	HSP90AA1, CCND1, CDKN2A, CDKN1A, MYOD1, MYCN
18	glycogen32 18	8.7	HDAC9, DES, SYP, GFAP, ACTC1, KRT8
19	glutamine32	7.5	PAX3, VIM, NCAM1, S100B, IL3, ENO2
20	bromodeoxyuridine32	7.1	DES, TGFA, GFAP, EGF, KRT1, KRT8
21	gefitinib32 34 9 9	10.1	ERBB4, AKT1, IGF2, IGF1R, CCND1, CDKN1A
22	curcumin32	7.0	HDAC9, WT1, CTNNB1, SPP1, PTGS2, TNFSF10
23	herbimycin a32 42	7.9	IL2, MYC, IL3, IGF1R, HSP90AA1, CXCR4
24	gemcitabine32 34 9 9	9.7	HDAC9, EGF, PTGS2, TNFSF10, TNFRSF10B, TNFRSF10A
25	doxorubicin32 34 9 9	9.6	DES, TGFA, EGF, KRT8, WT1, VIM
26	progesterone32 42 9 18 9	10.1	MYH11, HDAC9, DES, CDKN2A, CDH2, CDKN1A
27	steroid32	6.0	PTHLH, TNFSF10, TNFRSF10A, ERBB2, HSP90AA1, IGF2
28	etoposide32 42 9 9	8.5	ENO2, IL3, CDKN1A, S100B, CHGA, MYCN
29	paclitaxel32 34 9 9	8.3	CXCR4, TGFA, GFAP, EGF, KRT8, CTNNB1
30	actinomycin d32	4.7	TP53, PIK3CA, VIM, AIFM1, AKT1, CASP8
31	dmso32	INF	CTSD, , CHGA, VIM, ABL1, CXCR4
32	arginine32	INF	, IGF2, S100B, CHGA, MYOD1, REST
33	creatinine32	INF	, NCAM1, IGF2, IGF1R, ENO2, IL3
34	heparin32 9 18 9	INF	SPP1, PTHLH, ERBB2, ERBB4, , IGF2
35	cycloheximide32	INF	CXCR4, TGFA, GFAP, EGF, , IGF2
36	lactate32	INF	CXCR4, DES, TGFA, GFAP, KRT8, CTSD
37	oligonucleotide32	INF	HDAC9, CDH2, CDKN1A, CHGA, , PAX3
38	phosphatidylinositol32	INF	TNFSF10, PIK3CA, NCAM1, TNFRSF10C, TNFRSF10A, ERBB2
39	estrogen32	INF	EGF, KRT1, KRT8, WT1, SMARCA4, ERBB2
40	testosterone32 9 18 9	INF	CXCR4, DES, SYP, TGFA, GFAP, ACTC1
41	glutamate32	INF	CTSD, PIK3CA, NCAM1, VIM, SPP1, TNFSF10
42	cysteine32	INF	HDAC9, TGFA, GFAP, EGF, KRT8, SMARCA4
43	vegf32	INF	ACTC1, ABL1, KRT8, WT1, CTNNB1, CTSD
44	imatinib32 34 9 9	INF	S100B, , MYC, PIK3CA, CDKN1A, IL3
45	tamoxifen32 34 9 9	INF	HDAC9, TGFA, EGF, KRT8, CTNNB1, CTSD
46	b 72332	INF	DES, SYP, ACTC1, KRT8, WT1, PTPRC
47	tyrosine32	INF	KRT8, WT1, SMARCA4, CTNNB1, SPP1, PTPRC
48	ly29400232	INF	MYH11, HDAC9, SPP1, PTGS2, ERBB2, AIFM1
49	cytarabine32 34 9 9	INF	HDAC9, GFAP, ABL1, TNFSF10, TP53, HSP90AA1
50	alanine32	INF	IGF1R, IL3, CDKN2A, S100B, RASSF1, MYOD1

Cellular components related to rhabdoid tumors according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:005882	10.1	VIM, KRT8, KRT1, GFAP, DES
2	nucleoplasm	GO:005654	8.4	MYC, KRT8, WT1, SMARCB1, TP53, ERBB4
3	cytosol	GO:005829	INF	AIFM1, ERBB4, TP53, CTNNB1, ABL1, ACTC1

Biological processes related to rhabdoid tumors according to GeneDecks:

(show all 29)

id	Name	GO ID	Score	Top Affiliating Genes
1	muscle cell fate commitment	GO:042693	10.5	MYOG, MYF5, MYF6, MYOD1
2	skeletal muscle tissue development	GO:007519	10.3	MYOG, MYF5, MYF6, MYOD1
3	regulation of transcription from RNA polymerase II promoter	GO:006357	10.2	MYF6, MYCN, MYOD1, SMARCA4, SMARCB1, WT1
4	positive regulation of muscle cell differentiation	GO:051149	10.2	MYOG, MYF5, MYF6, MYOD1, CDH2, CTNNB1
5	muscle cell differentiation	GO:042692	10.1	ABL1, CTNNB1, CDH2, MYOD1, MYF6, MYF5
6	replicative senescence	GO:090399	10.0	CDKN2A, CDKN1A, TP53
7	regulation of angiogenesis	GO:045765	10.0	ID1, KRT1, CTNNB1, ERBB2
8	mammary gland alveolus development	GO:060749	9.9	TGFA, EGF, ERBB4, CCND1
9	positive regulation of anti-apoptosis	GO:045768	9.9	ERBB4, CDKN1A, CTNNB1, AKT1
10	G1 phase of mitotic cell cycle	GO:000080	9.8	CDKN1C, CDKN1A, CCND1, CDKN2A
11	positive regulation of protein phosphorylation	GO:001934	9.7	CCND1, ERBB2, IGF2, ERBB4, AKT1
12	cell cycle arrest	GO:007050	9.6	CDKN1A, TP53, CDKN1C, RASSF1, MYC, CDKN2A
13	positive regulation of apoptotic process	GO:043065	9.6	TNFSF10, PTPRC, CTNNB1, ABL1, TP53, REST
14	activation of pro-apoptotic gene products	GO:008633	9.5	CASP8, AKT1, TNFSF10, TNFRSF10B, MYC
15	induction of apoptosis by intracellular signals	GO:008629	9.4	MYC, TP53, CDKN1A, CASP8, AKT1
16	positive regulation of epithelial cell proliferation	GO:050679	9.4	ERBB4, MYC, TGFA, ERBB2
17	negative regulation of apoptotic process	GO:043066	9.3	MYC, ERBB4, CDKN1A, IGF1R, AKT1, WT1
18	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.3	ERBB4, IL3, IL2
19	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.2	TNFRSF10B, CDKN2A, CASP8, MYC, TNFSF10, AIFM1
20	response to drug	GO:042493	9.1	CTNNB1, PTGS2, MYC, CDKN1A, ERBB4, ACTC1
21	glucose metabolic process	GO:006006	9.1	IGF2, ENO2, MYC, PIK3CA, AKT1
22	positive regulation of transcription, DNA-dependent	GO:045893	9.0	TP53, WT1, EGF, SMARCA4, ERBB4, REST
23	negative regulation of cell proliferation	GO:008285	8.9	CDKN1A, CDKN2A, CDKN1C, ERBB4, TP53, REST
24	anti-apoptosis	GO:006916	8.9	IGF1R, TGFA, TNFRSF10D, AKT1, PIK3CA, IL2
25	heart development	GO:007507	8.9	HDAC9, ID1, WT1, ERBB4, ERBB2, CASP8
26	negative regulation of transcription, DNA-dependent	GO:045892	8.9	TP53, CTNNB1, REST, MYF6, EZH2, ID1
27	apoptotic process	GO:006915	8.5	ERBB4, TP53, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10
28	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.4	AKT1, TP53, CTNNB1, SMARCA4, SMARCB1, IL2
29	positive regulation of cell proliferation	GO:008284	8.3	EGF, MYC, IGF2, PTHLH, IL2, IL3

Molecular functions related to rhabdoid tumors according to GeneDecks:

(show all 10)

id	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:005200	10.2	KRT1, DES, GFAP, VIM, INA
2	p53 binding	GO:002039	10.1	MUC1, SMARCB1, SMARCA4, CDKN2A
3	TRAIL binding	GO:045569	10.1	TNFRSF10D, TNFRSF10C, TNFRSF10B, TNFRSF10A
4	E-box binding	GO:070888	10.0	MYC, MYOG, MYF5, MYF6, MYOD1
5	cyclin-dependent protein kinase inhibitor activity	GO:004861	9.7	CDKN1A, CDKN1C, CDKN2A
6	protein heterodimerization activity	GO:046982	9.1	MYOG, MYF5, MYF6, MYOD1, ENO2, ERBB2
7	transcription factor binding	GO:008134	9.0	CDKN2A, REST, MYC, MYOD1, HDAC9, CTNNB1
8	identical protein binding	GO:042802	8.9	VIM, CLDN6, RASSF1, IGF1R, STIM1, SYP
9	protein binding	GO:005515	INF	HDAC9, TP53, ERBB2, ERBB4, AIFM1, AKT1
10	protein tyrosine kinase activity	GO:004713	INF	, ERBB2, ERBB4, IGF1R, ABL1