MCID: RHB003
MIFTS: 57

Rhabdomyosarcoma malady

Categories: Neuronal diseases, Rare diseases, Cancer diseases

Aliases & Classifications for Rhabdomyosarcoma

Aliases & Descriptions for Rhabdomyosarcoma:

Name: Rhabdomyosarcoma 12 56 29 52 42 14 69

Characteristics:

Orphanet epidemiological data:

56
rhabdomyosarcoma
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:3247
MeSH 42 D012208
NCIt 47 C3359
Orphanet 56 ORPHA780
UMLS via Orphanet 70 C0035412
ICD10 via Orphanet 34 C49.9
MESH via Orphanet 43 D012208
UMLS 69 C0035412

Summaries for Rhabdomyosarcoma

Disease Ontology : 12 A skeletal muscle cancer that arise from skeletal muscle progenitors.

MalaCards based summary : Rhabdomyosarcoma is related to spindle cell rhabdomyosarcoma and bile duct rhabdomyosarcoma. An important gene associated with Rhabdomyosarcoma is ALK (ALK Receptor Tyrosine Kinase), and among its related pathways/superpathways are Immune response Function of MEF2 in T lymphocytes and Glioblastoma Multiforme. The drugs Cyclophosphamide and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include bone, skeletal muscle and prostate, and related phenotypes are growth/size/body region and behavior/neurological

Wikipedia : 71 Rhabdomyosarcoma, or RMS, is an aggressive and highly malignant form of cancer that develops from... more...

Related Diseases for Rhabdomyosarcoma

Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
id Related Disease Score Top Affiliating Genes
1 spindle cell rhabdomyosarcoma 33.5 FOXO1 MB MYOD1 MYOG PAX3
2 bile duct rhabdomyosarcoma 33.3 MB MYOD1 PAX3 PAX7
3 rhabdomyosarcoma 2, alveolar 33.1 FAM193B FOXO1 MB MDM2 MYCN MYOD1
4 mixed type rhabdomyosarcoma 33.0 MB MYOD1 MYOG
5 prostate rhabdomyosarcoma 32.9 GLI1 IGF2 MB MYCN MYOD1 MYOG
6 breast rhabdomyosarcoma 32.8 MYF6 PAX3
7 mediastinum rhabdomyosarcoma 32.5 FOXO1 IGF2 MB MYF6 MYOD1 MYOG
8 embryonal extrahepatic bile duct rhabdomyosarcoma 30.1 ALK FAM193B FEM1A FHL2 FOXO1 FOXO3
9 adenosarcoma 29.6 IGF2 MB MDM2 MYOG
10 embryonal rhabdomyosarcoma 12.3
11 botryoid rhabdomyosarcoma 12.1
12 rhabdomyosarcoma, somatic 12.1
13 prostate embryonal rhabdomyosarcoma 12.1
14 liver rhabdomyosarcoma 12.1
15 rhabdomyosarcoma, embryonal, 2 12.0
16 parameningeal embryonal rhabdomyosarcoma 12.0
17 pleomorphic rhabdomyosarcoma 12.0
18 orbit rhabdomyosarcoma 11.9
19 anus rhabdomyosarcoma 11.9
20 orbit embryonal rhabdomyosarcoma 11.8
21 central nervous system rhabdomyosarcoma 11.8
22 orbit alveolar rhabdomyosarcoma 11.8
23 vulvovaginal rhabdomyosarcoma 11.7
24 rhabdomyosarcoma of the corpus uteri 11.7
25 childhood pleomorphic rhabdomyosarcoma 11.7
26 gallbladder rhabdomyosarcoma 11.7
27 childhood botryoid rhabdomyosarcoma 11.7
28 rectum rhabdomyosarcoma 11.7
29 childhood vagina botryoid rhabdomyosarcoma 11.7
30 rhabdomyosarcoma of the cervix uteri 11.7
31 vulvar childhood botryoid-type embryonal rhabdomyosarcoma 11.7
32 ovary rhabdomyosarcoma 11.7
33 testis rhabdomyosarcoma 11.7
34 vagina botryoid rhabdomyosarcoma 11.6
35 adult botryoid rhabdomyosarcoma 11.6
36 adult vagina botryoid rhabdomyosarcoma 11.6
37 li-fraumeni syndrome 11.3
38 ectomesenchymoma 11.1
39 malignant ectomesenchymoma 11.0
40 mosaic variegated aneuploidy syndrome 1 10.9
41 large cell carcinoma with rhabdoid phenotype 10.9
42 mismatch repair cancer syndrome 10.9
43 malignant triton tumor 10.8
44 mosaic variegated aneuploidy syndrome 10.7
45 mosaic variegated aneuploidy syndrome 2 10.7
46 urachal cancer 10.7
47 breast cancer 10.4
48 sarcoma 10.4
49 subacute leukemia 10.3 MB MYOG
50 verruciform xanthoma of skin 10.3 MB MYOD1

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to Rhabdomyosarcoma

Symptoms & Phenotypes for Rhabdomyosarcoma

MGI Mouse Phenotypes related to Rhabdomyosarcoma:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.36 PAX3 PAX7 STIM1 TTN ALK FOXO1
2 behavior/neurological MP:0005386 10.32 ALK FOXO1 FOXO3 GLI1 IGF2 MDM2
3 cardiovascular system MP:0005385 10.31 FHL2 FOXO1 FOXO3 IGF2 MB MDM2
4 homeostasis/metabolism MP:0005376 10.31 FOXO3 IGF2 MB MDM2 MYCN MYF6
5 mortality/aging MP:0010768 10.31 ALK FOXO1 FOXO3 GLI1 IGF2 MB
6 cellular MP:0005384 10.3 MYCN PAX3 PAX7 STIM1 TTN GLI1
7 embryo MP:0005380 10.26 FOXO1 GLI1 IGF2 MB MDM2 MYCN
8 craniofacial MP:0005382 10.15 FOXO1 GLI1 IGF2 MDM2 MYCN PAX3
9 digestive/alimentary MP:0005381 10.14 FOXO1 FOXO3 GLI1 IGF2 MDM2 MYCN
10 muscle MP:0005369 10.14 MYOD1 MYOG PAX3 PAX7 TTN FOXO1
11 integument MP:0010771 10.08 ALK FOXO1 FOXO3 IGF2 MDM2 MYOG
12 neoplasm MP:0002006 10.02 FOXO3 GLI1 MDM2 MYF6 MYOD1 PAX3
13 no phenotypic analysis MP:0003012 10.02 FOXO1 GLI1 IGF2 MDM2 MYCN MYF6
14 normal MP:0002873 10 FHL2 FOXO1 GLI1 MDM2 MYCN MYF6
15 limbs/digits/tail MP:0005371 9.93 FOXO1 GLI1 IGF2 MDM2 MYCN PAX3
16 respiratory system MP:0005388 9.93 GLI1 IGF2 MB MYCN MYF6 MYOD1
17 skeleton MP:0005390 9.77 ALK FHL2 FOXO1 IGF2 MDM2 MYCN
18 vision/eye MP:0005391 9.28 ALK FOXO3 IGF2 MYCN MYF6 PAX3

Drugs & Therapeutics for Rhabdomyosarcoma

Drugs for Rhabdomyosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 273)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-18-0, 6055-19-2 2907
2
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
3
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
4 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
5 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
6 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
7 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Immunosuppressive Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
11
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
12
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
13
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
14
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
15
Morphine Approved, Investigational Phase 3,Phase 1,Phase 2 57-27-2 5288826
16
Topotecan Approved, Investigational Phase 3,Phase 2,Phase 1 119413-54-6, 123948-87-8 60700
17
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
18
Vinorelbine Approved, Investigational Phase 3,Phase 2,Phase 1 71486-22-1 60780 44424639
19
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
21
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 97682-44-5, 100286-90-6 60838
22
Everolimus Approved Phase 3,Phase 2,Phase 1 159351-69-6 6442177
23
Sirolimus Approved, Investigational Phase 3,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
24
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
25
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
26
Palivizumab Approved, Investigational Phase 3 188039-54-5
27
Ribavirin Approved Phase 3 36791-04-5 37542
28
Captopril Approved Phase 3 62571-86-2 44093
29
Fluconazole Approved Phase 3 86386-73-4 3365
30
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
31
Mechlorethamine Approved Phase 3,Phase 2,Phase 1 51-75-2 4033
32
Mesna Approved Phase 3,Phase 2,Phase 1 3375-50-6 598
33
Idarubicin Approved Phase 3 58957-92-9 42890
34
Cyproheptadine Approved Phase 3 129-03-3 2913
35
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
36
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
37
Mycophenolic acid Approved Phase 3 24280-93-1 446541
38
Camptothecin Experimental Phase 3,Phase 2,Phase 1 7689-03-4
39 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
40 Antimitotic Agents Phase 3,Phase 2,Phase 1
41 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
42 Etoposide phosphate Phase 3,Phase 2,Phase 1
43 Isophosphamide mustard Phase 3,Phase 2,Phase 1
44 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1
45 topoisomerase I inhibitors Phase 3,Phase 2,Phase 1
46 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
47 Antifungal Agents Phase 3,Phase 2,Phase 1
48 Antimetabolites Phase 3,Phase 2,Phase 1
49 Hormone Antagonists Phase 3,Phase 2,Phase 1
50 Hormones Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 248)
id Name Status NCT ID Phase
1 EpSSG (European Soft Tissue Sarcoma Study Group) Protocol for Non-Metastatic Rhabdomyosarcoma in Children Unknown status NCT00339118 Phase 4
2 Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma Unknown status NCT00379457 Phase 3
3 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Completed NCT00002995 Phase 3
4 Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma Completed NCT00003958 Phase 3
5 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3
6 Glutamic Acid in Reducing Nerve Damage Caused by Vincristine in Young Patients With Cancer Completed NCT00369564 Phase 3
7 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3
9 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3
10 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
11 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3
12 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3
13 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3
14 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3
15 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3
16 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3
17 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3
18 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3
19 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3
20 Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma Active, not recruiting NCT00075582 Phase 3
21 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Active, not recruiting NCT00354744 Phase 3
22 Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma Active, not recruiting NCT00354835 Phase 3
23 Combination Chemotherapy With or Without Temsirolimus in Treating Patients With Intermediate Risk Rhabdomyosarcoma Suspended NCT02567435 Phase 3
24 Rhabdomyosarcoma and Malignant Soft Tissue Tumours of Childhood Terminated NCT00162695 Phase 3
25 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3
26 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3
27 Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory or Relapsed Rhabdomyosarcoma : International Randomized Trial Unknown status NCT01355445 Phase 2
28 Vincristine, Dactinomycin, and Cyclophosphamide in Treating Patients With Embryonal Rhabdomyosarcoma Unknown status NCT00245089 Phase 2
29 Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Embryonal Rhabdomyosarcoma Unknown status NCT00245141 Phase 2
30 Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Rhabdomyosarcoma and Other Soft Tissue Sarcomas Unknown status NCT01216839 Phase 2
31 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2
32 Umbilical Cord Blood for Stem Cell Transplantation in Treating Young Patients With Malignant or Nonmalignant Diseases Unknown status NCT00084695 Phase 2
33 Light-Emitting Diode Therapy in Preventing Mucositis in Children Receiving Chemotherapy With or Without Radiation Therapy Before Bone Marrow Transplantation Unknown status NCT00036712 Phase 2
34 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2
35 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2
36 Exatecan Mesylate in Treating Children With Relapsed or Refractory Rhabdomyosarcoma Completed NCT00055939 Phase 2
37 Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma Completed NCT00025363 Phase 2
38 New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma Completed NCT00001335 Phase 2
39 Sorafenib Tosylate in Treating Younger Patients With Relapsed or Refractory Rhabdomyosarcoma, Wilms Tumor, Liver Cancer, or Thyroid Cancer Completed NCT01502410 Phase 2
40 Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Completed NCT01222715 Phase 2
41 Temozolomide, Cixutumumab, and Combination Chemotherapy in Treating Patients With Metastatic Rhabdomyosarcoma Completed NCT01055314 Phase 2
42 Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Metastatic Rhabdomyosarcoma or Sarcoma Completed NCT00003955 Phase 2
43 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2
44 Holmium Ho 166 DOTMP Followed by Peripheral Stem Cell Transplantation in Treating Patients With Metastatic Ewing's Sarcoma or Rhabdomyosarcoma That Has Spread to the Bone Completed NCT00006234 Phase 1, Phase 2
45 A Study of R1507 in Participants With Recurrent or Refractory Sarcoma Completed NCT00642941 Phase 2
46 Trabectedin in Treating Young Patients With Recurrent or Refractory Soft Tissue Sarcoma or Ewing's Family of Tumors Completed NCT00070109 Phase 2
47 A Pilot Study of Autologous T-Cell Transplantation With Vaccine Driven Expansion of Anti-Tumor Effectors After Cytoreductive Therapy in Metastatic Pediatric Sarcomas Completed NCT00001566 Phase 2
48 A Pilot Study of Tumor-Specific Peptide Vaccination and IL-2 With or Without Autologous T Cell Transplantation in Recurrent Pediatric Sarcomas Completed NCT00001564 Phase 2
49 A Five-Tier, Open-Label Study of IMC-A12 in Advanced Sarcoma Completed NCT00668148 Phase 2
50 A Study of Pemetrexed in Children With Recurrent Cancer Completed NCT00520936 Phase 2

Search NIH Clinical Center for Rhabdomyosarcoma

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rhabdomyosarcoma

Genetic Tests for Rhabdomyosarcoma

Genetic tests related to Rhabdomyosarcoma:

id Genetic test Affiliating Genes
1 Rhabdomyosarcoma 29

Anatomical Context for Rhabdomyosarcoma

MalaCards organs/tissues related to Rhabdomyosarcoma:

39
Bone, Skeletal Muscle, Prostate, Bone Marrow, Lung, Cervix, Breast

Publications for Rhabdomyosarcoma

Articles related to Rhabdomyosarcoma:

(show top 50) (show all 1971)
id Title Authors Year
1
Molecular diagnostics in the management of rhabdomyosarcoma. ( 28058850 )
2017
2
Co-occurrence of rhabdomyosarcoma and Mowat-Wilson syndrome: is there a connection? ( 28230647 )
2017
3
Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma. ( 28080960 )
2017
4
Primary Pulmonary Rhabdomyosarcoma in a Child. ( 28082783 )
2017
5
Costello Syndrome and Umbilical Ligament Rhabdomyosarcoma in Two Pediatric Patients: Case Reports and Review of the Literature. ( 28203467 )
2017
6
Cytotoxicity of Zardaverine in Embryonal Rhabdomyosarcoma from a Costello Syndrome Patient. ( 28421158 )
2017
7
A pharmacokinetic study of lipegfilgrastim in children with Ewing family of tumors or rhabdomyosarcoma. ( 27986986 )
2017
8
Suicide gene therapy of rhabdomyosarcoma. ( 28035376 )
2017
9
Identification of somatic and germ-line DICER1 mutations in pleuropulmonary blastoma, cystic nephroma and rhabdomyosarcoma tumors within a DICER1 syndrome pedigree. ( 28222777 )
2017
10
Adherence to Treatment, Response and Patterns of Failure in Pediatric Parameningeal Rhabdomyosarcoma: Experience From a Tertiary Cancer Care Center From India. ( 28060113 )
2017
11
Pleomorphic rhabdomyosarcoma arising in the anterior mediastinum: A case report with cytological features of imprint and liquid-based cytology specimens. ( 28024111 )
2016
12
Zebrafish Rhabdomyosarcoma. ( 27165362 )
2016
13
Current standards of care in bladder and prostate rhabdomyosarcoma. ( 26776454 )
2016
14
Alveolar rhabdomyosarcoma of maxilla. ( 27194887 )
2016
15
Respiratory Distress Secondary to Rhabdomyosarcoma of the Tongue and Co-existent Choanal Atresia. ( 27408448 )
2016
16
Misdiagnosis of primary pleomorphic rhabdomyosarcoma of the right thigh in a young adult: A case report. ( 27588141 )
2016
17
Embryonal rhabdomyosarcoma of the epididymis presenting as epididymitis: A case report. ( 27073679 )
2016
18
Is Metastatic Rhabdomyosarcoma an Indication for Cardioverter Defibrillator Implantation? ( 27138802 )
2016
19
c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines. ( 27104757 )
2016
20
The proprotein convertase furin is required to maintain viability of alveolar rhabdomyosarcoma cells. ( 27572312 )
2016
21
Pleomorphic rhabdomyosarcoma of the left atrium mimicking myxoma. ( 27510683 )
2016
22
Rhabdomyosarcoma of the breast: Report of two cases with the review of literature. ( 27046981 )
2016
23
Significance of delayed primary excision in localized nonmetastatic adult head and neck rhabdomyosarcoma. ( 27565892 )
2016
24
Embryonal rhabdomyosarcoma: A rare oral tumor. ( 27721622 )
2016
25
Quality of life and functional outcome of male patients with bladder-prostate rhabdomyosarcoma treated with conservative surgery and brachytherapy during childhood. ( 26895712 )
2016
26
Small GTPase Arl6 controls RH30 rhabdomyosarcoma cell growth through ciliogenesis and Hedgehog signaling. ( 27999656 )
2016
27
Primary embryonal rhabdomyosarcoma of the liver. ( 28039349 )
2016
28
Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model. ( 27966453 )
2016
29
Embryonal rhabdomyosarcoma in a patient with a heterozygous frameshift variant in the DICER1 gene and additional manifestations of the DICER1 syndrome. ( 27896549 )
2016
30
A rare case of multifocal pseudomyogenic hemangioendothelioma, involving soft tissues and bone, misdiagnosed as a rhabdomyosarcoma: Diagnostic and treatment implications. ( 27510684 )
2016
31
Role of magnetic resonance imaging in the early diagnosis of paratesticular rhabdomyosarcoma. ( 27087341 )
2016
32
Myxoma virus therapy for human embryonal rhabdomyosarcoma in a nude mouse model. ( 27579297 )
2016
33
Primary Pleomorphic Rhabdomyosarcoma of Thyroid Gland in an Adult Patient: A Case Report. ( 27026769 )
2016
34
Improvements in the Treatment of Patients Suffering from Bladder-Prostate Rhabdomyosarcoma: A Report from the CWS-2002P Trial. ( 27387676 )
2016
35
Key role of MEK/ERK pathway in sustaining tumorigenicity and in vitro radioresistance of embryonal rhabdomyosarcoma stem-like cell population. ( 26897742 )
2016
36
Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: Lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies. ( 27459057 )
2016
37
Disruption of myoblast alignment by highly motile rhabdomyosarcoma cell in tissue structure. ( 27590346 )
2016
38
Pleomorphic rhabdomyosarcoma with an impressive response to chemotherapy: case report and review of the literature. ( 26952562 )
2016
39
Alveolar rhabdomyosarcoma of the sphenoid sinus mimicking optic neuritis presenting with intermittent visual loss in an adult. ( 27932889 )
2016
40
Embryonal rhabdomyosarcoma in a child exposed to chemotherapy in utero: a mere coincidence? ( 27802874 )
2016
41
Primary Renal Rhabdomyosarcoma: An Unusual Bone Metastasizing Tumor of Kidney. ( 27182845 )
2016
42
A Toddler with Rhabdomyosarcoma Presenting as Acute Otitis Media with Mastoid Abscess. ( 27174338 )
2016
43
Deep sequencing reveals a novel miR-22 regulatory network with therapeutic potential in rhabdomyosarcoma. ( 27569217 )
2016
44
Multiparametric MRI findings of sinonasal rhabdomyosarcoma in adults with comparison to carcinoma. ( 27648498 )
2016
45
Increased Nicotinamide Phosphoribosyltransferase in Rhabdomyosarcomas and Leiomyosarcomas Compared to Skeletal and Smooth Muscle Tissue. ( 26851003 )
2016
46
Erectile function after treatment for rhabdomyosarcoma of prostate and bladder. ( 27570092 )
2016
47
Treatment Outcome and Predictors of Survival in Thai Adult Rhabdomyosarcoma Cases. ( 27039788 )
2016
48
Paternal uniparental disomy with segmental loss of heterozygosity of chromosome 11 are hallmark characteristics of syndromic and sporadic embryonal rhabdomyosarcoma. ( 27589201 )
2016
49
Pleomorphic Rhabdomyosarcoma Arising from True Vocal Fold of Larynx: Report of a Rare Case and Literature Review. ( 27699075 )
2016
50
Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells. ( 27960157 )
2016

Variations for Rhabdomyosarcoma

ClinVar genetic disease variations for Rhabdomyosarcoma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 BRCA1 NM_007294.3(BRCA1): c.844_850dupTCATTAC (p.Gln284Leufs) duplication Pathogenic rs80357989 GRCh37 Chromosome 17, 41246698: 41246704
2 ALK NM_004304.4(ALK): c.3673G> A (p.Asp1225Asn) single nucleotide variant Pathogenic rs1057519696 GRCh37 Chromosome 2, 29436920: 29436920
3 FGFR4 NM_213647.2(FGFR4): c.1605C> A (p.Asn535Lys) single nucleotide variant Likely pathogenic rs1057519792 GRCh37 Chromosome 5, 176522416: 176522416
4 FGFR4 NM_213647.2(FGFR4): c.1605C> G (p.Asn535Lys) single nucleotide variant Likely pathogenic rs1057519792 GRCh37 Chromosome 5, 176522416: 176522416
5 FGFR4 NM_213647.2(FGFR4): c.1649T> A (p.Val550Glu) single nucleotide variant Likely pathogenic rs1057519793 GRCh37 Chromosome 5, 176522552: 176522552

Cosmic variations for Rhabdomyosarcoma:

9 (show top 50) (show all 57)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM11081 TP53 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.733G>T p.G245C 6
2 COSM45255 TP53 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.668C>G p.P223R 6
3 COSM45005 TP53 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.739A>G p.N247D 6
4 COSM13016 PTPN11 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 6
5 COSM13014 PTPN11 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.214G>A p.A72T 6
6 COSM14271 PTPN11 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.1508G>T p.G503V 6
7 COSM13013 PTPN11 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.205G>A p.E69K 6
8 COSM775 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.3140A>G p.H1047R 6
9 COSM763 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.1633G>A p.E545K 6
10 COSM760 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.1624G>A p.E542K 6
11 COSM585 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.183A>T p.Q61H 6
12 COSM584 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.182A>G p.Q61R 6
13 COSM564 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.35G>A p.G12D 6
14 COSM580 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.181C>A p.Q61K 6
15 COSM574 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.38G>T p.G13V 6
16 COSM569 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.37G>C p.G13R 6
17 COSM562 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.34G>T p.G12C 6
18 COSM563 NRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.34G>A p.G12S 6
19 COSM1745010 MYOD1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.365T>G p.L122R 6
20 COSM521 KRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.35G>A p.G12D 6
21 COSM516 KRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.34G>T p.G12C 6
22 COSM553 KRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.182A>T p.Q61L 6
23 COSM522 KRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.35G>C p.G12A 6
24 COSM483 HRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.35G>T p.G12V 6
25 COSM480 HRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.34G>A p.G12S 6
26 COSM496 HRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.181C>A p.Q61K 6
27 COSM486 HRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.37G>C p.G13R 6
28 COSM481 HRAS soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.34G>T p.G12C 6
29 COSM3744763 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5428G>T p.D1810Y 6
30 COSM959251 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5113G>A p.E1705K 6
31 COSM3738459 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5437G>A p.E1813K 6
32 COSM4169595 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5425G>A p.G1809R 6
33 COSM3738549 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5365-1G>T p.? 6
34 COSM3738451 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.5439G>T p.E1813D 6
35 COSM393242 DICER1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.2062C>T p.R688* 6
36 COSM5664 CTNNB1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.121A>G p.T41A 6
37 COSM5692 CTNNB1 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.134C>A p.S45Y 6
38 COSM1651691 ALK soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.3830T>C p.I1277T 6
39 COSM143842 ALK soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.3673G>A p.D1225N 6
40 COSM99938 soft tissue,striated muscle,rhabdomyosarcoma,embryonal c.37G>C p.G13R 6
41 COSM45256 TP53 soft tissue,striated muscle,rhabdomyosarcoma,NS c.871A>C p.K291Q 5
42 COSM10813 TP53 soft tissue,striated muscle,rhabdomyosarcoma,NS c.394A>G p.K132E 5
43 COSM44536 TP53 soft tissue,striated muscle,rhabdomyosarcoma,NS c.728T>C p.M243T 5
44 COSM45253 TP53 soft tissue,striated muscle,rhabdomyosarcoma,NS c.611A>G p.E204G 5
45 COSM10660 TP53 soft tissue,striated muscle,rhabdomyosarcoma,NS c.818G>A p.R273H 5
46 COSM766 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,NS c.1636C>A p.Q546K 5
47 COSM1235326 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,NS c.3023C>T p.S1008F 5
48 COSM762 PIK3CA soft tissue,striated muscle,rhabdomyosarcoma,NS c.1625A>T p.E542V 5
49 COSM586 NRAS soft tissue,striated muscle,rhabdomyosarcoma,NS c.183A>C p.Q61H 5
50 COSM532 KRAS soft tissue,striated muscle,rhabdomyosarcoma,NS c.38G>A p.G13D 5

Copy number variations for Rhabdomyosarcoma from CNVD:

7 (show all 19)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 32214 1 34600000 40100000 Amplification MYCL1 Rhabdomyosarcoma
2 48341 11 1 2800000 Loss HRAS Rhabdomyosarcoma
3 55467 11 532242 535550 Mutation HRAS Rhabdomyosarcoma
4 69397 12 54900000 58100000 Amplification or los s GLI Rhabdomyosarcoma
5 69949 12 56600000 58100000 Amplification CDK4 Rhabdomyosarcoma
6 69950 12 56600000 58100000 Amplification SAS Rhabdomyosarcoma
7 79876 13 79000000 101700000 Amplification C13orf25 Rhabdomyosarcoma
8 79877 13 79000000 101700000 Amplification GPC5 Rhabdomyosarcoma
9 106840 17 1 3300000 Loss HIC1 Rhabdomyosarcoma
10 106842 17 1 3300000 Loss Rhabdomyosarcoma
11 106969 17 10700000 22200000 Loss Rhabdomyosarcoma
12 110141 17 314735 515143 Loss Rhabdomyosarcoma
13 127361 19 32400000 43400000 Amplification AKT2 Rhabdomyosarcoma
14 185187 4 187100000 191154276 Loss Rhabdomyosarcoma
15 187611 4 52700000 59500000 Loss PDGFRA Rhabdomyosarcoma
16 187815 4 55095264 55146925 Amplificationlicatio n PDGFRA Rhabdomyosarcoma
17 187856 4 55524095 55606879 Amplificationlicatio n C-Kit Rhabdomyosarcoma
18 239020 8 36500000 45600000 Amplification FGFR1 Rhabdomyosarcoma
19 253524 9 43600000 47300000 Loss Rhabdomyosarcoma

Expression for Rhabdomyosarcoma

Search GEO for disease gene expression data for Rhabdomyosarcoma.

Pathways for Rhabdomyosarcoma

GO Terms for Rhabdomyosarcoma

Cellular components related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.32 FAM193B FHL2 FOXO1 FOXO3 GLI1 MDM2

Biological processes related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.97 FOXO1 FOXO3 GLI1 MYCN MYF6 MYOD1
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.95 FHL2 FOXO1 FOXO3 MYCN MYF6 MYOD1
3 skeletal muscle cell differentiation GO:0035914 9.72 MYF6 MYOD1 MYOG
4 positive regulation of muscle cell differentiation GO:0051149 9.69 MYF6 MYOD1 MYOG
5 positive regulation of myoblast differentiation GO:0045663 9.67 MYF6 MYOD1 MYOG
6 skeletal muscle tissue development GO:0007519 9.67 MYF6 MYOD1 MYOG PAX7
7 skeletal muscle tissue regeneration GO:0043403 9.65 MYF6 MYOG PAX7
8 positive regulation of myoblast fusion GO:1901741 9.63 MYF6 MYOD1 MYOG
9 myotube differentiation GO:0014902 9.61 MYOD1 MYOG STIM1
10 myoblast differentiation GO:0045445 9.6 MYOD1 MYOG
11 enamel mineralization GO:0070166 9.58 FOXO1 STIM1
12 regulation of neural precursor cell proliferation GO:2000177 9.58 FOXO1 FOXO3
13 muscle tissue morphogenesis GO:0060415 9.56 MYF6 PAX7
14 muscle organ development GO:0007517 9.55 MYF6 MYOD1 MYOG PAX3 PAX7
15 response to water-immersion restraint stress GO:1990785 9.54 FOXO3 MDM2
16 positive regulation of skeletal muscle fiber development GO:0048743 9.43 MYF6 MYOD1 MYOG
17 positive regulation of transcription, DNA-templated GO:0045893 9.28 FHL2 FOXO1 FOXO3 GLI1 MYCN MYF6
18 muscle cell fate commitment GO:0042693 9.13 MYF6 MYOD1 MYOG
19 regulation of transcription, DNA-templated GO:0006355 10.26 FHL2 FOXO1 FOXO3 GLI1 IGF2 MYCN
20 transcription, DNA-templated GO:0006351 10.24 FHL2 FOXO1 FOXO3 GLI1 MYCN MYOD1
21 multicellular organism development GO:0007275 10.11 GLI1 IGF2 MYF6 MYOD1 MYOG PAX3

Molecular functions related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.8 FOXO1 FOXO3 MYOD1 MYOG PAX3 PAX7
2 ubiquitin protein ligase binding GO:0031625 9.76 FOXO1 MDM2 MYOD1 SLC22A18
3 protein dimerization activity GO:0046983 9.73 MYCN MYF6 MYOD1 MYOG
4 core promoter binding GO:0001047 9.58 FOXO3 MYOD1 MYOG
5 transcription factor activity, sequence-specific DNA binding GO:0003700 9.56 FOXO1 FOXO3 MYCN MYF6 MYOD1 MYOG
6 chromatin DNA binding GO:0031490 9.54 FOXO3 MYOD1 MYOG
7 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 9.46 FOXO3 MYF6 MYOD1 MYOG
8 E-box binding GO:0070888 9.43 MYF6 MYOD1 MYOG
9 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 8.92 GLI1 MYF6 MYOD1 MYOG

Sources for Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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