MCID: RHB003
MIFTS: 48

Rhabdomyosarcoma malady

Summaries for Rhabdomyosarcoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 A rhabdomyosarcoma, commonly referred to as RMS, is a type of cancer, specifically a sarcoma (cancer of... more...

MalaCards: Rhabdomyosarcoma, also known as rhabdomyosarcoma, no subtype, is related to alveolar rhabdomyosarcoma and beckwith-wiedemann syndrome. An important gene associated with Rhabdomyosarcoma is TTN (titin), and among its related pathways are Signaling events mediated by HDAC Class III and AKT phosphorylates targets in the nucleus. The drugs cyclophosphamide and etoposide and the compound glycogen have been mentioned in the context of this disorder.

Disease Ontology:8 A myosarcoma that arise from skeletal muscle progenitors.

Aliases & Classifications for Rhabdomyosarcoma

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

rhabdomyosarcoma 8 10 45 61
rhabdomyosarcoma, no subtype 8
rhabdomyosarcoma nos 8
rhabdomyoblastoma 8


External Ids:

Disease Ontology8 DOID:3247
NCIt40 C3359
MeSH35 D012208

Related Diseases for Rhabdomyosarcoma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1alveolar rhabdomyosarcoma31.6PAX7, PAX3, FOXO1
2beckwith-wiedemann syndrome30.2SLC22A18, IGF2, TSSC4
3rhabdomyosarcoma 2, alveolar30.2PAX3, PAX7
4wilms tumor30.1IGF2, SLC22A18
5rhabdoid tumor30.1IGF2, STIM1
6adenocarcinoma30.1XAGE1D
7botryoid rhabdomyosarcoma10.7
8spindle cell rhabdomyosarcoma10.6
9breast rhabdomyosarcoma10.5
10soft tissue sarcoma10.5
11orbit embryonal rhabdomyosarcoma10.5
12prostate embryonal rhabdomyosarcoma10.5
13embryonal sarcoma10.5
14adult pleomorphic rhabdomyosarcoma10.4
15orbit alveolar rhabdomyosarcoma10.4
16n syndrome10.4
17liver rhabdomyosarcoma10.4
18bile duct rhabdomyosarcoma10.3
19ovary rhabdomyosarcoma10.3
20testis rhabdomyosarcoma10.3
21adult botryoid rhabdomyosarcoma10.3
22gallbladder rhabdomyosarcoma10.3
23mediastinum rhabdomyosarcoma10.3
24acute leukemia10.3
25vagina botryoid rhabdomyosarcoma10.3
26costello syndrome10.2
27rectum rhabdomyosarcoma10.2
28rhabdomyosarcoma, somatic10.2
29teratoma10.2
30mixed type rhabdomyosarcoma10.2
31anus rhabdomyosarcoma10.2
32noonan syndrome10.2
33ectomesenchymoma10.2
34choledochal cyst10.2
35hypercalcemia10.2
36vulvovaginal rhabdomyosarcoma10.2
37neurofibromatosis10.1
38central nervous system rhabdomyosarcoma10.1
39childhood vagina botryoid rhabdomyosarcoma10.1
40vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.1
41bladder sarcoma10.1
42childhood pleomorphic rhabdomyosarcoma10.1
43small cell sarcoma10.1
44malignant mesenchymal tumor10.1
45epidermal nevus10.1
46testicular germ cell tumor10.1
47uterine inversion10.0
48embryonal extrahepatic bile duct rhabdomyosarcoma10.0
49childhood botryoid rhabdomyosarcoma10.0
50ganglioneuroma10.0

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to rhabdomyosarcoma

Clinical Features for Rhabdomyosarcoma

Drugs & Therapeutics for Rhabdomyosarcoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Rhabdomyosarcoma

Search NIH Clinical Center for Rhabdomyosarcoma

Search CenterWatch for Rhabdomyosarcoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Rhabdomyosarcoma

Anatomical Context for Rhabdomyosarcoma

Animal Models for Rhabdomyosarcoma or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Rhabdomyosarcoma

Sources:
51PubMed
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Articles related to Rhabdomyosarcoma:

(show top 50)    (show all 1728)
idTitleAuthorsYear
1
Sinonasal rhabdomyosarcoma: prognostic factors and treatment outcomes. (23424037)
2013
2
Delayed development of a rhabdomyosarcoma following radiation for a spinal cord glioma. (23296545)
2013
3
Renal rhabdomyosarcoma in a pancake kidney. (23639240)
2013
4
Prostate embryonal rhabdomyosarcoma in adults: Case report and review of literature. (24416569)
2013
5
Silibinin improves the cytotoxicity of methotrexate in chemo resistant human rhabdomyosarcoma cell lines. (24252892)
2013
6
Alveolar ethmoidal rhabdomyosarcoma in a young adult male. (23476011)
2013
7
Detection of PAX3/PAX7-FKHR fusion transcripts in rhabdomyosarcoma and other small round cell tumors by 1-step reverse transcriptase polymerase chain reaction: a novel tool for diagnosis and differentiation. (22197543)
2012
8
Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma. (22682622)
2012
9
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
10
Rhabdomyosarcoma of the skin resembling carcinosarcoma: report of a case and literature review. (22262364)
2012
11
Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma. (22577581)
2012
12
Susceptibility of rhabdomyosarcoma cells to macrophage-mediated cytotoxicity. (22737603)
2012
13
Emerging trends in the management of laryngeal rhabdomyosarcoma. (24436487)
2012
14
CIITA is silenced by epigenetic mechanisms that prevent the recruitment of transactivating factors in rhabdomyosarcoma cells. (21989738)
2012
15
RBPJ is a novel target for rhabdomyosarcoma therapy. (22792167)
2012
16
Prevalence of germline TP53 mutations and history of Li-Fraumeni syndrome in families with childhood adrenocortical tumors, choroid plexus tumors, and rhabdomyosarcoma: a population-based survey. (22653678)
2012
17
A case of tumor lysis syndrome following chemotherapy for a uterine epithelioid leiomyosarcoma with focal rhabdomyosarcomatous differentiation. (21410837)
2011
18
Limits and chances in an unfortunate course of recurrent orbital rhabdomyosarcoma. (21876600)
2011
19
Caveolins in rhabdomyosarcoma. (21707915)
2011
20
Pathology quiz case 1. Diagnosis: laryngeal rhabdomyosarcoma, embryonal subtype. (21690521)
2011
21
CD133 positive embryonal rhabdomyosarcoma stem-like cell population is enriched in rhabdospheres. (21602936)
2011
22
Establishment and characterization of canine rhabdomyosarcoma cell line CMS-C. (21519159)
2011
23
Embryonal rhabdomyosarcoma of the rectum: report of a case and possible treatment option. (19486088)
2010
24
A rare case of paratesticular pleomorphic rhabdomyosarcoma diagnosed by fine needle aspiration: a case report. (19790247)
2010
25
Noonan syndrome, the SOS1 gene and embryonal rhabdomyosarcoma. (20461756)
2010
26
Genetic and molecular alterations in rhabdomyosarcoma: mRNA overexpression of MCL1 and MAP2K4 genes. (19012245)
2009
27
Embryonal rhabdomyosarcoma in a young Maine coon cat. (19122064)
2009
28
Rhabdomyosarcoma in a patient with Noonan syndrome phenotype and review of the literature. (17483716)
2007
29
Palpebral pleomorphic rhabdomyosarcoma in a teenager. (16946759)
2007
30
Use of a novel FISH assay on paraffin-embedded tissues as an adjunct to diagnosis of alveolar rhabdomyosarcoma. (16607381)
2006
31
Adult sclerosing rhabdomyosarcoma: cytogenetic link with embryonal rhabdomyosarcoma. (15660283)
2005
32
Rhabdomyosarcoma development in Trp53/fos mutant mice: tumor suppressor functions of the Fos protooncogene]. (16892556)
2004
33
Embryonal rhabdomyosarcoma presenting in an adult: a case report and discussion of immunohistochemical staining. (12544100)
2003
34
Pilot trial of tumor-specific peptide vaccination and continuous infusion interleukin-2 in patients with recurrent Ewing sarcoma and alveolar rhabdomyosarcoma: an inter-institute NIH study. (11836714)
2002
35
PAX3-FKHR and PAX7-FKHR gene fusions are prognostic indicators in alveolar rhabdomyosarcoma: a report from the children's oncology group. (12039929)
2002
36
Lactoferrin inhibits enterovirus 71 infection of human embryonal rhabdomyosarcoma cells in vitro. (12355368)
2002
37
Usefulness of immunohistochemical testing and electron microscopy in the diagnosis of embryonal rhabdomyosarcoma. (11782672)
2002
38
Isochromosome (17)(q10) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. (11454423)
2001
39
Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports. (10955690)
2000
40
Alveolar rhabdomyosarcoma metastatic to the breast: long-term survivor. (10663335)
1999
41
Pathologic features of rhabdomyosarcoma before and after treatment: a clinicopathologic and immunohistochemical analysis. (9436961)
1997
42
Reduction of tumorigenicity by alpha 3 integrin in a rhabdomyosarcoma cell line. (8870972)
1996
43
Suramin inhibits the growth of human rhabdomyosarcoma by interrupting the insulin-like growth factor II autocrine growth loop. (1312901)
1992
44
Orbital rhabdomyosarcoma. Immunohistochemical studies of seven cases. (2119961)
1990
45
Fatal breast rhabdomyosarcoma in a 15 year old primigravida. (2379516)
1990
46
Malignant islet cell tumor with rhabdomyosarcomatous differentiation. (2540663)
1989
47
Prognostic importance of nucleolar organiser regions in embryonal rhabdomyosarcoma. (3366938)
1988
48
Embryonal rhabdomyosarcoma of the face. (6491323)
1984
49
Pelvic exenteration for vaginal embryonal rhabdomyosarcoma: a review. (1090863)
1975
50
Botryoid rhabdomyosarcoma of the urinary bladder and hypertrophic osteoarthropathy in a young dog. (4473190)
1974

Genetic Variations for Rhabdomyosarcoma

Expression for genes affiliated with Rhabdomyosarcoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdomyosarcoma

Search GEO for disease gene expression data for Rhabdomyosarcoma.

Pathways for genes affiliated with Rhabdomyosarcoma

Sources:
38NCBI BioSystems Database, 54Reactome
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Pathways related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FOXO3, FOXO1, FHL2
2
Hide members
10.7FOXO3, FOXO1

Compounds for genes affiliated with Rhabdomyosarcoma

Sources:
45Novoseek, 24HMDB
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Compounds related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glycogen45 2411.9TTN, IGF2, FOXO3, FOXO1

GO Terms for genes affiliated with Rhabdomyosarcoma

Sources:
16Gene Ontology
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Cellular components related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1M bandGO:03143010.7TTN, FHL2

Biological processes related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:00828610.8IGF2, FOXO3, FOXO1
2spinal cord association neuron differentiationGO:02152710.7PAX7, PAX3
3neuron fate commitmentGO:04866310.6PAX7, PAX3
4tissue developmentGO:00988810.4FOXO3, FOXO1

Products for genes affiliated with Rhabdomyosarcoma

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Sources for Rhabdomyosarcoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet