MCID: RHB003
MIFTS: 49

Rhabdomyosarcoma malady

Neuronal diseases, Cancer diseases, Rare diseases categories

Aliases & Classifications for Rhabdomyosarcoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet
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Rhabdomyosarcoma, Aliases & Descriptions:

Name: Rhabdomyosarcoma 9 11 43 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
rhabdomyosarcoma:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/1000000 (Europe); Age of onset: Childhood


External Ids:

Disease Ontology9 DOID:3247
NCIt38 C3359
MeSH33 D012208
Orphanet47 780
MESH via Orphanet34 D012208
ICD10 via Orphanet26 C49
UMLS via Orphanet61 C0035412

Summaries for Rhabdomyosarcoma

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Wikipedia:63 A rhabdomyosarcoma, commonly referred to as RMS, is a type of cancer, specifically a sarcoma (cancer of... more...

MalaCards based summary: Rhabdomyosarcoma is related to embryonal rhabdomyosarcoma and sarcoma. An important gene associated with Rhabdomyosarcoma is TTN (titin), and among its related pathways are Class I PI3K signaling events mediated by Akt and Transcriptional misregulation in cancer. The drugs cyclophosphamide and dacarbazine and the compounds testosterone and glycogen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, prostate and cervix, and related mouse phenotypes are digestive/alimentary and craniofacial.

Disease Ontology:9 A skeletal muscle cancer that arise from skeletal muscle progenitors.

Related Diseases for Rhabdomyosarcoma

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Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma32.0IGF2, PAX7, PAX3
2sarcoma31.2IGF2, PAX7, PAX3, FOXO1
3rhabdomyosarcoma 2, alveolar31.0FOXO1, PAX3, PAX7
4wilms tumor30.6SLC22A18, IGF2
5ewing sarcoma30.5XAGE1D, PAX3, PAX7, IGF2
6mismatch repair cancer syndrome30.3PAX7, PAX3, FOXO1
7beckwith-wiedemann syndrome30.2SLC22A18, TSSC4, IGF2
8rhabdoid tumor30.1IGF2, STIM1
9melanoma29.7FHL2, XAGE1D, PAX3, PAX7, PMS1
10breast cancer29.5IGF2, PMS1, FOXO3, FOXO1, FHL2, SLC22A18
11pleomorphic rhabdomyosarcoma10.8
12prostatitis10.7
13botryoid rhabdomyosarcoma10.6
14spindle cell rhabdomyosarcoma10.6
15prostate rhabdomyosarcoma10.6
16soft tissue sarcoma10.5
17orbit rhabdomyosarcoma10.5
18orbit embryonal rhabdomyosarcoma10.4
19neuroblastoma10.4
20prostate embryonal rhabdomyosarcoma10.4
21laryngitis10.4
22leukemia10.3
23costello syndrome10.3
24myoma10.3PAX3, FOXO1
25rhabdomyosarcoma, somatic10.3
26orbit alveolar rhabdomyosarcoma10.3
27cervicitis10.3
28liver rhabdomyosarcoma10.3
29breast rhabdomyosarcoma10.3
30cerebritis10.3
31sinusitis10.2
32central nervous system rhabdomyosarcoma10.2
33mediastinum rhabdomyosarcoma10.2
34ectomesenchymoma10.2
35anus rhabdomyosarcoma10.2
36mixed type rhabdomyosarcoma10.2
37choledochal cyst10.2
38vaginitis10.2
39teratoma10.2
40li-fraumeni syndrome10.2
41neuroectodermal tumor10.2
42ovary rhabdomyosarcoma10.2
43rectum rhabdomyosarcoma10.2
44gallbladder rhabdomyosarcoma10.2
45testis rhabdomyosarcoma10.2
46nasopharyngitis10.2
47childhood pleomorphic rhabdomyosarcoma10.2
48hypercalcemia10.2
49bile duct rhabdomyosarcoma10.2
50leiomyosarcoma10.2

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to rhabdomyosarcoma

Symptoms for Rhabdomyosarcoma

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Drugs & Therapeutics for Rhabdomyosarcoma

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Drug clinical trials:

Search ClinicalTrials for Rhabdomyosarcoma

Search NIH Clinical Center for Rhabdomyosarcoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Rhabdomyosarcoma

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Anatomical Context for Rhabdomyosarcoma

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MalaCards organs/tissues related to Rhabdomyosarcoma:

31
Skeletal muscle, Prostate, Cervix, Bone, Breast, Bone marrow, Uterus, Liver, Lymph node, Brain, Lung, Skin, Ovary, Tongue, Kidney, Testes, Thyroid, Testis, Endothelial, T cells, Heart, Colon, Trachea, Spinal cord, Smooth muscle, Pancreas, Myeloid, Pituitary, Eye, Adipocyte, Salivary gland, Adrenal gland, B cells, Temporal lobe, Pineal

Animal Models for Rhabdomyosarcoma or affiliated genes

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MGI Mouse Phenotypes related to Rhabdomyosarcoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.3FOXO1, FOXO3, PAX3, PAX7, IGF2
2MP:00053829.3IGF2, TTN, PAX7, PAX3, FOXO1
3MP:00020069.3PMS1, PAX7, PAX3, FOXO3, FOXO1
4MP:00053909.2FHL2, IGF2, TTN, PAX7, PAX3, STIM1
5MP:00053889.1IGF2, PAX7, PAX3, STIM1, FOXO3
6MP:00053859.0IGF2, TTN, PAX3, STIM1, FOXO3, FOXO1
7MP:00053878.8PPP2R3C, IGF2, TTN, PAX7, PAX3, STIM1

Publications for Rhabdomyosarcoma

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Articles related to Rhabdomyosarcoma:

(show top 50)    (show all 1781)
idTitleAuthorsYear
1
A mistaken identity: rhabdomyosarcoma of the middle ear cleft misdiagnosed as chronic suppurative otitis media with temporal lobe abscess. (25240007)
2014
2
Rare embryonal rhabdomyosarcoma of external acoustic canal: a case report and literature review. (25128187)
2014
3
Embryonal rhabdomyosarcoma of upper lid in 15-year-old patient. (24716058)
2014
4
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations. (24793135)
2014
5
Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. (23821038)
2013
6
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
7
Outcome of Rhabdomyosarcoma in First Year of Life: Children's Cancer Hospital 57357 Egypt. (23983569)
2013
8
Vulvar embryonal rhabdomyosarcoma: a case report. (23602842)
2013
9
Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model. (23665330)
2013
10
Molecular targeted therapies for rhabdomyosarcoma: focus on hedgehog and apoptosis signaling. (23625685)
2013
11
Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array. (23578105)
2013
12
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. (23230269)
2013
13
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. (24009521)
2013
14
Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: a systems biology approach. (22322884)
2012
15
Long-term results in childhood rhabdomyosarcoma: a report from the Italian Cooperative Study RMS 79. (22028198)
2012
16
The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. (22983009)
2012
17
Embryonal rhabdomyosarcoma of the auricle in a child. (23279030)
2012
18
Detection of PAX3/PAX7-FKHR fusion transcripts in rhabdomyosarcoma and other small round cell tumors by 1-step reverse transcriptase polymerase chain reaction: a novel tool for diagnosis and differentiation. (22197543)
2012
19
Breast metastasis from rhabdomyosarcoma of the nasal septum in a pregnant adult woman. (21631632)
2011
20
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)
2010
21
Cross-talk between MAP kinase pathways is involved in IGF-independent, IGFBP-6-induced Rh30 rhabdomyosarcoma cell migration. (20432455)
2010
22
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. (21278891)
2010
23
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
24
Pathology quiz case 2. Alveolar rhabdomyosarcoma. (18936365)
2008
25
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. (17611698)
2007
26
Embryonal rhabdomyosarcoma of the uterus in a postmenopausal woman. Case report and review of the literature. (16684558)
2006
27
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report. (17177904)
2006
28
Adult sclerosing rhabdomyosarcoma: cytogenetic link with embryonal rhabdomyosarcoma. (15660283)
2005
29
Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma. (16082247)
2005
30
Sclerosing rhabdomyosarcoma in childhood: case report and review of the literature. (15383934)
2004
31
Re: Does bladder preservation (as a surgical principle) lead to retaining bladder function in bladder/prostate rhabdomyosarcoma? Results from Intergroup Rhabdomyosarcoma Study IV. (15540797)
2004
32
Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. (11688574)
2001
33
Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. (10674913)
2000
34
PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma. (10439042)
1999
35
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. (10029080)
1999
36
Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD. (9581851)
1998
37
Solid alveolar rhabdomyosarcoma of the thorax in a child. (9543674)
1998
38
Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (9150430)
1997
39
Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. (8917562)
1996
40
In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2. (7923191)
1994
41
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
42
Suramin inhibits the growth of human rhabdomyosarcoma by interrupting the insulin-like growth factor II autocrine growth loop. (1312901)
1992
43
Monosialoganglioside biosynthesis by subcellular membranes of rhabdomyosarcoma cell lines differing in metastatic potential. (2335400)
1990
44
Alveolar rhabdomyosarcoma--a case report. (3223793)
1988
45
Embryonal rhabdomyosarcoma. (3135349)
1988
46
Left atrial rhabdomyosarcoma mimicking mitral valve stenosis. (15227049)
1985
47
Ossification in a soft tissue embryonal rhabdomyosarcoma. (6795580)
1981
48
Multidisciplinary treatment of advanced stages of embryonal rhabdomyosarcoma in children. (7029285)
1981
49
Combined radical surgery, radiation therapy and chemotherapy in infants with vulvovaginal embryonal rhabdomyosarcoma. (4742656)
1973
50
Alveolar rhabdomyosarcoma. (5040564)
1972

Variations for Rhabdomyosarcoma

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Expression for genes affiliated with Rhabdomyosarcoma

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Search GEO for disease gene expression data for Rhabdomyosarcoma.

Pathways for genes affiliated with Rhabdomyosarcoma

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Pathways related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0FOXO1, FOXO3
29.8PAX7, PAX3, FOXO1
39.8FHL2, FOXO1, FOXO3
4
Show member pathways
9.7FOXO1, FOXO3, STIM1

Compounds for genes affiliated with Rhabdomyosarcoma

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Sources:
43Novoseek, 59Tocris Bioscience, 24HMDB, 12DrugBank
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Compounds related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1testosterone43 59 24 1212.6FHL2, FOXO1, FOXO3, IGF2
2glycogen43 2410.3FOXO1, FOXO3, TTN, IGF2

GO Terms for genes affiliated with Rhabdomyosarcoma

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Cellular components related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1M bandGO:003143010.1FHL2, TTN

Biological processes related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1spinal cord association neuron differentiationGO:002152710.1PAX7, PAX3
2neuron fate commitmentGO:004866310.1PAX3, PAX7
3tissue developmentGO:00098889.7FOXO1, FOXO3
4insulin receptor signaling pathwayGO:00082869.6IGF2, FOXO3, FOXO1
5positive regulation of transcription, DNA-templatedGO:00458939.6FHL2, FOXO1, FOXO3, PAX3
6positive regulation of transcription from RNA polymerase II promoterGO:00459449.5FOXO1, FOXO3, PAX3, PAX7, IGF2

Molecular functions related to Rhabdomyosarcoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:00435659.6FOXO1, FOXO3, PAX3, PAX7

Products for genes affiliated with Rhabdomyosarcoma

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Sources for Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet