MCID: RHB003
MIFTS: 57

Rhabdomyosarcoma malady

Cancer diseases category
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Summaries for Rhabdomyosarcoma

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8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 A rhabdomyosarcoma, commonly referred to as RMS, is a type of cancer, specifically a sarcoma (cancer of... more...

MalaCards: Rhabdomyosarcoma, also known as rhabdomyosarcoma, no subtype, is related to embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma. An important gene associated with Rhabdomyosarcoma is TTN (titin), and among its related pathways are Class I PI3K signaling events mediated by Akt and Transcriptional misregulation in cancer. The drugs cyclophosphamide and dacarbazine and the compounds testosterone and glycogen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, prostate and cervix, and related mouse phenotypes are digestive/alimentary and craniofacial.

Disease Ontology:8 A skeletal muscle cancer that arise from skeletal muscle progenitors.

Aliases & Classifications for Rhabdomyosarcoma

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

rhabdomyosarcoma 8 10 45 62
rhabdomyosarcoma, no subtype 8
rhabdomyosarcoma nos 8
rhabdomyoblastoma 8


External Ids:

Disease Ontology8 DOID:3247
NCIt40 C3359
MeSH35 D012208

Related Diseases for Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma31.8IGF2, PAX7, PAX3
2alveolar rhabdomyosarcoma31.7FOXO1, PAX3, PAX7
3sarcoma31.1IGF2, PAX7, PAX3, FOXO1
4wilms tumor30.3SLC22A18, IGF2
5beckwith-wiedemann syndrome30.2SLC22A18, TSSC4, IGF2
6rhabdoid tumor30.1IGF2, STIM1
7melanoma29.9FHL2, XAGE1D, PAX3, PAX7, PMS1
8breast cancer29.7IGF2, PMS1, FOXO3, FOXO1, FHL2, SLC22A18
9pleomorphic rhabdomyosarcoma10.8
10prostatitis10.7
11botryoid rhabdomyosarcoma10.6
12spindle cell rhabdomyosarcoma10.5
13prostate rhabdomyosarcoma10.5
14soft tissue sarcoma10.5
15orbit rhabdomyosarcoma10.5
16neuroblastoma10.4
17orbit embryonal rhabdomyosarcoma10.4
18prostate embryonal rhabdomyosarcoma10.3
19laryngitis10.3
20leukemia10.3
21osteosarcoma10.3
22cerebritis10.2
23costello syndrome10.2
24germ cell tumors10.2
25liver rhabdomyosarcoma10.2
26breast rhabdomyosarcoma10.2
27orbit alveolar rhabdomyosarcoma10.2
28cervicitis10.2
29rhabdomyosarcoma, somatic10.2
30teratoma10.2
31mediastinum rhabdomyosarcoma10.2
32ectomesenchymoma10.2
33mixed type rhabdomyosarcoma10.2
34choledochal cyst10.2
35nasopharyngitis10.2
36hypercalcemia10.2
37noonan syndrome10.2
38bile duct rhabdomyosarcoma10.2
39leiomyosarcoma10.2
40mediastinitis10.2
41nephroblastoma10.2
42vaginitis10.2
43sinusitis10.2
44vulvar childhood botryoid-type embryonal rhabdomyosarcoma10.1
45childhood vagina botryoid rhabdomyosarcoma10.1
46central nervous system rhabdomyosarcoma10.1
47gallbladder rhabdomyosarcoma10.1
48ovary rhabdomyosarcoma10.1
49rectum rhabdomyosarcoma10.1
50testis rhabdomyosarcoma10.1

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to rhabdomyosarcoma

Symptoms for Rhabdomyosarcoma

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Drugs & Therapeutics for Rhabdomyosarcoma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rhabdomyosarcoma

Search NIH Clinical Center for Rhabdomyosarcoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Rhabdomyosarcoma

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Anatomical Context for Rhabdomyosarcoma

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33MalaCards
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MalaCards organs/tissues related to Rhabdomyosarcoma:

33
Skeletal muscle, Prostate, Cervix, Bone, Breast, Bone marrow, Uterus, Liver, Lung, Brain, Ovary, Kidney, Tongue, Lymph node, Skin, Testes, Endothelial, Testis, T cells, Thyroid, Heart, Colon, Myeloid, Trachea, Pituitary, Pancreas, Smooth muscle, Spinal cord, Adrenal gland, Adipocyte, B cells, Eye, Salivary gland

Animal Models for Rhabdomyosarcoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Rhabdomyosarcoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.3PAX7, IGF2, FOXO1, PAX3, FOXO3
2MP:00053829.3PAX3, PAX7, TTN, IGF2, FOXO1
3MP:00020069.3PMS1, FOXO1, FOXO3, PAX3, PAX7
4MP:00053909.2FHL2, IGF2, TTN, PAX7, PAX3, STIM1
5MP:00053889.1PAX7, PAX3, IGF2, FOXO3, STIM1
6MP:00053859.0FOXO1, IGF2, TTN, PAX3, STIM1, FHL2
7MP:00053878.8FOXO1, FOXO3, STIM1, PAX3, PAX7, TTN

Publications for Rhabdomyosarcoma

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52PubMed
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Articles related to Rhabdomyosarcoma:

(show top 50)    (show all 1679)
idTitleAuthorsYear
1
Zebrafish rhabdomyosarcoma reflects the developmental stage of oncogene expression during myogenesis. (23821038)
2013
2
Embryonal rhabdomyosarcoma arising from a mediastinal teratoma: an unusual case report. (23487585)
2013
3
Outcome of Rhabdomyosarcoma in First Year of Life: Children's Cancer Hospital 57357 Egypt. (23983569)
2013
4
Vulvar embryonal rhabdomyosarcoma: a case report. (23602842)
2013
5
Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model. (23665330)
2013
6
Molecular targeted therapies for rhabdomyosarcoma: focus on hedgehog and apoptosis signaling. (23625685)
2013
7
Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array. (23578105)
2013
8
Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors. (23230269)
2013
9
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. (24009521)
2013
10
Sinonasal rhabdomyosarcoma: prognostic factors and treatment outcomes. (23424037)
2013
11
Pathway simulations in common oncogenic drivers of leukemic and rhabdomyosarcoma cells: a systems biology approach. (22322884)
2012
12
The ablation of EZH2 uncovers its crucial role in rhabdomyosarcoma formation. (22983009)
2012
13
Embryonal rhabdomyosarcoma of the auricle in a child. (23279030)
2012
14
Detection of PAX3/PAX7-FKHR fusion transcripts in rhabdomyosarcoma and other small round cell tumors by 1-step reverse transcriptase polymerase chain reaction: a novel tool for diagnosis and differentiation. (22197543)
2012
15
Breast metastasis from rhabdomyosarcoma of the nasal septum in a pregnant adult woman. (21631632)
2011
16
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)
2010
17
Cross-talk between MAP kinase pathways is involved in IGF-independent, IGFBP-6-induced Rh30 rhabdomyosarcoma cell migration. (20432455)
2010
18
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. (21278891)
2010
19
Cytogenetic and real-time quantitative reverse-transcriptase polymerase chain reaction analyses in pleomorphic rhabdomyosarcoma. (19480930)
2009
20
Pathology quiz case 2. Alveolar rhabdomyosarcoma. (18936365)
2008
21
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. (17611698)
2007
22
Embryonal rhabdomyosarcoma of the uterus in a postmenopausal woman. Case report and review of the literature. (16684558)
2006
23
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report. (17177904)
2006
24
Validation of met as a therapeutic target in alveolar and embryonal rhabdomyosarcoma. (16651427)
2006
25
Adult sclerosing rhabdomyosarcoma: cytogenetic link with embryonal rhabdomyosarcoma. (15660283)
2005
26
Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma. (16082247)
2005
27
Sclerosing rhabdomyosarcoma in childhood: case report and review of the literature. (15383934)
2004
28
Re: Does bladder preservation (as a surgical principle) lead to retaining bladder function in bladder/prostate rhabdomyosarcoma? Results from Intergroup Rhabdomyosarcoma Study IV. (15540797)
2004
29
Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. (11688574)
2001
30
Temporary remission of an alveolar rhabdomyosarcoma diagnosed and treated as acute leukemia. (10674913)
2000
31
PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabdomyosarcoma. (10439042)
1999
32
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. (10029080)
1999
33
High creatine kinase MB concentration and activity in patients with rhabdomyosarcoma]. (10590688)
1999
34
Elevated cyclins and cyclin-dependent kinase activity in the rhabdomyosarcoma cell line RD. (9581851)
1998
35
Solid alveolar rhabdomyosarcoma of the thorax in a child. (9543674)
1998
36
Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (9150430)
1997
37
Induction of apoptosis in rhabdomyosarcoma cells through down-regulation of PAX proteins. (8917562)
1996
38
In vivo treatment with antibody against IGF-1 receptor suppresses growth of human rhabdomyosarcoma and down-regulates p34cdc2. (7923191)
1994
39
Pleomorphic rhabdomyosarcoma in adulthood. Analysis of 11 cases with definition of diagnostic criteria. (8333559)
1993
40
Suramin inhibits the growth of human rhabdomyosarcoma by interrupting the insulin-like growth factor II autocrine growth loop. (1312901)
1992
41
Abdominal embryonal rhabdomyosarcoma. A case report. (1515977)
1992
42
Monosialoganglioside biosynthesis by subcellular membranes of rhabdomyosarcoma cell lines differing in metastatic potential. (2335400)
1990
43
Characterization of an embryonal rhabdomyosarcoma cell line showing amplification and over-expression of the N-myc oncogene. (2323848)
1990
44
Alveolar rhabdomyosarcoma--a case report. (3223793)
1988
45
Embryonal rhabdomyosarcoma. (3135349)
1988
46
Left atrial rhabdomyosarcoma mimicking mitral valve stenosis. (15227049)
1985
47
Ossification in a soft tissue embryonal rhabdomyosarcoma. (6795580)
1981
48
Multidisciplinary treatment of advanced stages of embryonal rhabdomyosarcoma in children. (7029285)
1981
49
Combined radical surgery, radiation therapy and chemotherapy in infants with vulvovaginal embryonal rhabdomyosarcoma. (4742656)
1973
50
Alveolar rhabdomyosarcoma. (5040564)
1972

Variations for Rhabdomyosarcoma

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Expression for genes affiliated with Rhabdomyosarcoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdomyosarcoma

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Pathways for genes affiliated with Rhabdomyosarcoma

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50PathCards, 38NCBI BioSystems Database, 30KEGG, 55Reactome
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Compounds for genes affiliated with Rhabdomyosarcoma

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45Novoseek, 61Tocris Bioscience, 24HMDB, 11DrugBank
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Compounds related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1testosterone45 61 24 1112.6FHL2, FOXO1, FOXO3, IGF2
2glycogen45 2410.3FOXO1, FOXO3, TTN, IGF2

GO Terms for genes affiliated with Rhabdomyosarcoma

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16Gene Ontology
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Cellular components related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1M bandGO:03143010.1FHL2, TTN

Biological processes related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1spinal cord association neuron differentiationGO:02152710.1PAX3, PAX7
2neuron fate commitmentGO:04866310.1PAX7, PAX3
3tissue developmentGO:0098889.7FOXO3, FOXO1
4insulin receptor signaling pathwayGO:0082869.6FOXO1, IGF2, FOXO3
5positive regulation of transcription, DNA-templatedGO:0458939.6PAX3, FOXO1, FHL2, FOXO3
6positive regulation of transcription from RNA polymerase II promoterGO:0459449.5IGF2, PAX7, PAX3, FOXO3, FOXO1

Molecular functions related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sequence-specific DNA bindingGO:0435659.6FOXO1, FOXO3, PAX3, PAX7

Products for genes affiliated with Rhabdomyosarcoma

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Sources for Rhabdomyosarcoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet