MCID: RHB003
MIFTS: 54

Rhabdomyosarcoma malady

Summaries for Rhabdomyosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A rhabdomyosarcoma, commonly referred to as RMS, is a type of cancer, specifically a sarcoma (cancer of... more...

MalaCards: Rhabdomyosarcoma, also known as rhabdomyosarcoma, no subtype, is related to embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma. An important gene associated with Rhabdomyosarcoma is TTN (titin), and among its related pathways are Signaling events mediated by HDAC Class III and AKT phosphorylates targets in the nucleus. The drugs cyclophosphamide and etoposide and the compound glycogen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, prostate and cervix.

Disease Ontology:8 A myosarcoma that arise from skeletal muscle progenitors.

Aliases & Classifications for Rhabdomyosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

rhabdomyosarcoma 8 10 44 60
rhabdomyosarcoma, no subtype 8
rhabdomyosarcoma nos 8
rhabdomyoblastoma 8


External Ids:

Disease Ontology8 DOID:3247
NCIt39 C3359
MeSH34 D012208

Related Diseases for Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma31.6PAX3, PAX7, IGF2
2alveolar rhabdomyosarcoma31.6PAX7, PAX3, FOXO1
3sarcoma31.0FOXO1, IGF2, PAX3, PAX7
4beckwith-wiedemann syndrome30.2SLC22A18, IGF2, TSSC4
5rhabdomyosarcoma 2, alveolar30.1PAX3, PAX7
6adenocarcinoma30.1XAGE1D
7melanoma29.9PAX7, PAX3, FHL2, XAGE1D, PMS1
8breast cancer29.6SLC22A18, FOXO3, FOXO1, FHL2, PMS1, IGF2
9pleomorphic rhabdomyosarcoma10.7
10botryoid rhabdomyosarcoma10.7
11prostate rhabdomyosarcoma10.7
12orbit rhabdomyosarcoma10.6
13prostatitis10.6
14spindle cell rhabdomyosarcoma10.6
15prostate embryonal rhabdomyosarcoma10.5
16breast rhabdomyosarcoma10.5
17orbit embryonal rhabdomyosarcoma10.5
18adult pleomorphic rhabdomyosarcoma10.4
19orbit alveolar rhabdomyosarcoma10.3
20liver rhabdomyosarcoma10.3
21neuroblastoma10.3
22bile duct rhabdomyosarcoma10.3
23laryngitis10.3
24ovary rhabdomyosarcoma10.3
25leukemia10.3
26osteosarcoma10.3
27testis rhabdomyosarcoma10.2
28adult botryoid rhabdomyosarcoma10.2
29gallbladder rhabdomyosarcoma10.2
30mediastinum rhabdomyosarcoma10.2
31acute leukemia10.2
32cerebritis10.2
33costello syndrome10.2
34rectum rhabdomyosarcoma10.2
35vagina botryoid rhabdomyosarcoma10.2
36mixed type rhabdomyosarcoma10.2
37anus rhabdomyosarcoma10.2
38cervicitis10.2
39rhabdomyosarcoma, somatic10.2
40noonan syndrome10.1
41ectomesenchymoma10.1
42choledochal cyst10.1
43nasopharyngitis10.1
44hypercalcemia10.1
45leiomyosarcoma10.1
46mediastinitis10.1
47nephroblastoma10.1
48vaginitis10.1
49central nervous system rhabdomyosarcoma10.1
50childhood vagina botryoid rhabdomyosarcoma10.1

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to rhabdomyosarcoma

Clinical Features for Rhabdomyosarcoma

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Drugs & Therapeutics for Rhabdomyosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Rhabdomyosarcoma

Search NIH Clinical Center for Rhabdomyosarcoma

Search CenterWatch for Rhabdomyosarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Rhabdomyosarcoma

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Anatomical Context for Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Rhabdomyosarcoma:

32
Skeletal muscle, Prostate, Cervix, Bone, Breast, Bone marrow, Uterus, Liver, Lung, Brain, Ovary, Kidney, Tongue, Lymph node, Skin, Testes, Endothelial, Testis, T cells, Thyroid, Heart, Colon, Myeloid, Trachea, Pituitary, Pancreas, Smooth muscle, Spinal cord, Adrenal gland, Adipocyte, B cells, Eye, Salivary gland

Animal Models for Rhabdomyosarcoma or affiliated genes

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Publications for Rhabdomyosarcoma

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50PubMed
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Articles related to Rhabdomyosarcoma:

(show top 50)    (show all 1694)
idTitleAuthorsYear
1
Cross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcoma. (24009521)
2013
2
Sclerosing rhabdomyosarcoma presenting in the masseter muscle: a case report. (23379991)
2013
3
Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534). (24124571)
2013
4
Distinct effects of ligand-induced PDGFRI+ and PDGFRI^ signaling in the human rhabdomyosarcoma tumor cell and stroma cell compartments. (23338608)
2013
5
Renal rhabdomyosarcoma in a pancake kidney. (23639240)
2013
6
Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. (23002204)
2012
7
Complete genome sequence of two coxsackievirus A1 strains that were cytotoxic to human rhabdomyosarcoma cells. (22923792)
2012
8
Perianal embryonal rhabdomyosarcoma diagnosed by endoscopic ultrasound-guided fine needle aspiration. (23012012)
2012
9
Contribution of PET/CT to prediction of outcome in children and young adults with rhabdomyosarcoma. (21903740)
2011
10
Limits and chances in an unfortunate course of recurrent orbital rhabdomyosarcoma. (21876600)
2011
11
Primary embryonal rhabdomyosarcoma of the prostate in adults: report of a case and review of the literature. (21427103)
2011
12
Differentiation of human rhabdomyosarcoma RD cells is regulated by reciprocal, functional interactions between myostatin, p38 and extracellular regulated kinase signalling pathways. (21273059)
2011
13
Rhabdomyosarcoma of the oral cavity: a case report. (21769278)
2011
14
Embryonal rhabdomyosarcoma of the rectum: report of a case and possible treatment option. (19486088)
2010
15
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice. (19155313)
2009
16
RAS signaling dysregulation in human embryonal Rhabdomyosarcoma. (19681119)
2009
17
Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for the treatment of pediatric rhabdomyosarcomas. (19887553)
2009
18
PAX5 expression in rhabdomyosarcoma. (19641453)
2009
19
Alveolar rhabdomyosarcoma of the left hand with bilateral breast metastases in an adolescent female. (19114329)
2008
20
The estrogen receptor pathway in rhabdomyosarcoma: a role for estrogen receptor-beta in proliferation and response to the antiestrogen 4'OH-tamoxifen. (18451176)
2008
21
Primary pleomorphic rhabdomyosarcoma of the kidney in an adult. (18621001)
2008
22
Expression of cardiac ankyrin repeat protein, CARP, in malignant tumors: diagnostic use of CARP protein immunostaining in rhabdomyosarcoma. (18656235)
2008
23
Primary embryonal rhabdomyosarcoma of the breast. (17330703)
2007
24
Role for amplification and expression of glypican-5 in rhabdomyosarcoma. (17210683)
2007
25
Identification and epitope enhancement of a PAX-FKHR fusion protein breakpoint epitope in alveolar rhabdomyosarcoma cells created by a tumorigenic chromosomal translocation inducing CTL capable of lysing human tumors. (16452243)
2006
26
Alveolar rhabdomyosarcoma mimicking a lymphoma at presentation. (16921060)
2006
27
Hypercalcemia and local production of parathyroid hormone-related protein by a perisellar rhabdomyosarcoma after remote pituitary irradiation. (16239205)
2005
28
Alveolar rhabdomyosarcoma in infantile spinal muscular atrophy: coincidence or predisposition? (15639120)
2005
29
Expression of multidrug resistance-associated proteins in rhabdomyosarcomas before and after chemotherapy: the relationship between lung resistance-related protein (LRP) and differentiation. (12612883)
2003
30
Concerning "Five additional Costello syndrome patients with rhabdomyosarcoma: proposal for a tumor screening protocol". (12698963)
2003
31
HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells. (12142554)
2002
32
Pleomorphic rhabdomyosarcoma in an adult forearm: a case report. (11810631)
2002
33
Forkhead homologue in rhabdomyosarcoma functions as a bifunctional nuclear receptor-interacting protein with both coactivator and corepressor functions. (11353774)
2001
34
Primary ovarian rhabdomyosarcoma associated with clear cell carcinoma of the ovary: a case report and review of the literature. (10782415)
2000
35
Rapid growth of a retroperitoneal rhabdomyosarcoma following right hemicolectomy for ascending colon cancer: report of a case. (10795872)
2000
36
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells. (10029080)
1999
37
Evidence of genetic alterations in chromosome 11 in embryonal and alveolar rhabdomyosarcoma]. (10095436)
1998
38
Prostate rhabdomyosarcoma in a young adult: a case study. (9278381)
1997
39
Expression and parental imprinting of the H19 gene in human rhabdomyosarcoma. (9136994)
1997
40
Testicular embryonal rhabdomyosarcoma diagnosed by fine needle aspiration cytology. A report of two cases. (8042425)
1994
41
Actin, tropomyosin and alpha-actinin as markers of differentiation in human rhabdomyosarcoma cell lines induced with dimethyl sulfoxide. (8374504)
1993
42
The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells. (1315746)
1992
43
Variant translocations of chromosome 13 in alveolar rhabdomyosarcoma. (1777415)
1991
44
Embryonal rhabdomyosarcoma arising in a mature teratoma of the testis: a case report. (2188021)
1990
45
Embryonal rhabdomyosarcoma of the face. (6491323)
1984
46
Congenital orbital alveolar rhabdomyosarcoma. (6579973)
1983
47
Epidermal nevus and rhabdomyosarcoma. (962336)
1976
48
Alveolar rhabdomyosarcoma. (5040564)
1972
49
Embryonal rhabdomyosarcoma of the middle ear with long-term survival. (5538640)
1971
50
Embryonal rhabdomyosarcoma of the middle ear primary to so-called medullomyoblastoma of brain. (5446604)
1970

Genetic Variations for Rhabdomyosarcoma

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Expression for genes affiliated with Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdomyosarcoma

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Pathways for genes affiliated with Rhabdomyosarcoma

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FOXO3, FOXO1, FHL2
2
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10.7FOXO3, FOXO1

Compounds for genes affiliated with Rhabdomyosarcoma

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44Novoseek, 24HMDB
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Compounds related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glycogen44 2411.9TTN, IGF2, FOXO3, FOXO1

GO Terms for genes affiliated with Rhabdomyosarcoma

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16Gene Ontology
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Cellular components related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1M bandGO:03143010.7TTN, FHL2

Biological processes related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:00828610.8IGF2, FOXO3, FOXO1
2spinal cord association neuron differentiationGO:02152710.7PAX7, PAX3
3neuron fate commitmentGO:04866310.6PAX7, PAX3
4tissue developmentGO:00988810.4FOXO3, FOXO1

Products for genes affiliated with Rhabdomyosarcoma

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Sources for Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet