MCID: RHB003
MIFTS: 54

Rhabdomyosarcoma malady

Summaries for Rhabdomyosarcoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A rhabdomyosarcoma, commonly referred to as RMS, is a type of cancer, specifically a sarcoma (cancer of... more...

MalaCards: Rhabdomyosarcoma, also known as rhabdomyosarcoma, no subtype, is related to embryonal rhabdomyosarcoma and alveolar rhabdomyosarcoma. An important gene associated with Rhabdomyosarcoma is TTN (titin), and among its related pathways are Signaling events mediated by HDAC Class III and AKT phosphorylates targets in the nucleus. The drugs cyclophosphamide and etoposide and the compound glycogen have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, prostate and cervix.

Disease Ontology:8 A myosarcoma that arise from skeletal muscle progenitors.

Aliases & Classifications for Rhabdomyosarcoma

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

rhabdomyosarcoma 8 10 44 60
rhabdomyosarcoma, no subtype 8
rhabdomyosarcoma nos 8
rhabdomyoblastoma 8


External Ids:

Disease Ontology8 DOID:3247
NCIt39 C3359
MeSH34 D012208

Related Diseases for Rhabdomyosarcoma

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17GeneCards, 18GeneDecks
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Diseases related to Rhabdomyosarcoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 248)
idRelated DiseaseScoreTop Affiliating Genes
1embryonal rhabdomyosarcoma31.6PAX3, PAX7, IGF2
2alveolar rhabdomyosarcoma31.6PAX7, PAX3, FOXO1
3sarcoma31.0FOXO1, IGF2, PAX3, PAX7
4beckwith-wiedemann syndrome30.2SLC22A18, IGF2, TSSC4
5rhabdomyosarcoma 2, alveolar30.1PAX3, PAX7
6adenocarcinoma30.1XAGE1D
7melanoma29.9PAX7, PAX3, FHL2, XAGE1D, PMS1
8breast cancer29.6SLC22A18, FOXO3, FOXO1, FHL2, PMS1, IGF2
9pleomorphic rhabdomyosarcoma10.7
10botryoid rhabdomyosarcoma10.7
11prostate rhabdomyosarcoma10.7
12orbit rhabdomyosarcoma10.6
13prostatitis10.6
14spindle cell rhabdomyosarcoma10.6
15prostate embryonal rhabdomyosarcoma10.5
16breast rhabdomyosarcoma10.5
17orbit embryonal rhabdomyosarcoma10.5
18adult pleomorphic rhabdomyosarcoma10.4
19orbit alveolar rhabdomyosarcoma10.3
20liver rhabdomyosarcoma10.3
21neuroblastoma10.3
22bile duct rhabdomyosarcoma10.3
23laryngitis10.3
24ovary rhabdomyosarcoma10.3
25leukemia10.3
26osteosarcoma10.3
27testis rhabdomyosarcoma10.2
28adult botryoid rhabdomyosarcoma10.2
29gallbladder rhabdomyosarcoma10.2
30mediastinum rhabdomyosarcoma10.2
31acute leukemia10.2
32cerebritis10.2
33costello syndrome10.2
34rectum rhabdomyosarcoma10.2
35vagina botryoid rhabdomyosarcoma10.2
36mixed type rhabdomyosarcoma10.2
37anus rhabdomyosarcoma10.2
38cervicitis10.2
39rhabdomyosarcoma, somatic10.2
40noonan syndrome10.1
41ectomesenchymoma10.1
42choledochal cyst10.1
43nasopharyngitis10.1
44hypercalcemia10.1
45leiomyosarcoma10.1
46mediastinitis10.1
47nephroblastoma10.1
48vaginitis10.1
49central nervous system rhabdomyosarcoma10.1
50childhood vagina botryoid rhabdomyosarcoma10.1

Graphical network of the top 20 diseases related to Rhabdomyosarcoma:



Diseases related to rhabdomyosarcoma

Clinical Features for Rhabdomyosarcoma

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Drugs & Therapeutics for Rhabdomyosarcoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rhabdomyosarcoma

Drug clinical trials:

Search ClinicalTrials for Rhabdomyosarcoma

Search NIH Clinical Center for Rhabdomyosarcoma

Search CenterWatch for Rhabdomyosarcoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Rhabdomyosarcoma

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Anatomical Context for Rhabdomyosarcoma

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32MalaCards
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MalaCards organs/tissues related to Rhabdomyosarcoma:

32
Skeletal muscle, Prostate, Cervix, Bone, Breast, Bone marrow, Uterus, Liver, Brain, Lung, Ovary, Kidney, Tongue, Lymph node, Skin, Testis, Testes, Endothelial, T cells, Thyroid, Heart, Colon, Pancreas, Smooth muscle, Pituitary, Myeloid, Trachea, Spinal cord, B cells, Salivary gland, Adrenal gland, Eye, Adipocyte

Animal Models for Rhabdomyosarcoma or affiliated genes

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Publications for Rhabdomyosarcoma

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50PubMed
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Articles related to Rhabdomyosarcoma:

(show top 50)    (show all 1694)
idTitleAuthorsYear
1
Comprehensive Genomic Analysis of Rhabdomyosarcoma Reveals a Landscape of Alterations Affecting a Common Genetic Axis in Fusion-Positive and Fusion-Negative Tumors. (24436047)
2014
2
Genitourinary rhabdomyosarcoma: unusual diagnosis presenting within hours of delivery. (23510697)
2013
3
Spindle cell rhabdomyosarcoma of the neck with t(6;8) translocation: report of a case and literature review. (23113671)
2013
4
Embryonal rhabdomyosarcoma of the uterus in a 35-year-old woman: case report and review of the literature. (24020141)
2013
5
Composite uterine neoplasm with embryonal rhabdomyosarcoma and primitive neuroectodermal tumor components: rhabdomyosarcoma with divergent differentiation, variant of primitive neuroectodermal tumor, or unique entity? (23266445)
2013
6
Paranuclear dot-like immunostaining of CD99 in rhabdomyosarcoma. (23347163)
2013
7
Primary embryonal rhabdomyosarcoma of the anterior neck and thyroid: report of a new case with review of the literature. (23625578)
2013
8
Characterization of Wnt/I^-catenin signaling in rhabdomyosarcoma. (23999248)
2013
9
Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. (22653355)
2012
10
Massive diffuse intraperitoneal multicystic mass in an infant. Botryoid rhabdomyosarcoma (RMS). (22421724)
2012
11
PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma. (21882254)
2011
12
Primary adult intratesticular rhabdomyosarcoma: results of the treatment of six cases. (21272089)
2011
13
Solid alveolar rhabdomyosarcoma with spindle-shaped cells and epithelial differentiation of the mediastinum in a 68-year-old man: a case report and literature review. (22044824)
2011
14
Successful treatment of a very rare case: locally treated cervical rhabdomyosarcoma. (21748315)
2011
15
Exfoliative cytologic findings of maxillary sinus spindle cell rhabdomyosarcoma. (20518428)
2010
16
Touch preparation of primary uterine pleomorphic rhabdomyosarcoma: report of a case with clinical cytopathologic features. (21053592)
2010
17
Diagnosis of alveolar rhabdomyosarcoma in effusion cytology: a diagnostic pitfall. (19843149)
2010
18
Embryonal rhabdomyosarcoma: adjuvant and ex vivo assay-directed chemotherapy. (20442589)
2010
19
Aggressive spindle cell rhabdomyosarcoma in an 11-month-old boxer dog. (20460837)
2010
20
Immunohistochemical detection of EGFR, fibrillin-2, P-cadherin and AP2beta as biomarkers for rhabdomyosarcoma diagnostics. (19469909)
2009
21
Hedgehog-independent overexpression of transforming growth factor-beta1 in rhabdomyosarcoma of Patched1 mutant mice. (17611698)
2007
22
Alveolar rhabdomyosarcoma presenting as an acute orbital mass in the medial rectus muscle. (17413634)
2007
23
Alveolar rhabdomyosarcoma mimicking lymphoma with bone marrow involvement. (17008999)
2007
24
Blocking enhancive effect of vascular endothelial growth factor on proliferation of rhabdomyosarcoma cell line RH4 by avastin]. (16764767)
2006
25
Spindle cell rhabdomyosarcoma of the tongue in an infant: a case report with emphasis on differential diagnosis of childhood spindle cell lesions. (15462501)
2004
26
Pleomorphic rhabdomyosarcoma of the anterior abdominal wall following multimodality treatment for carcinoma of the rectum. (15173925)
2004
27
Embryonal rhabdomyosarcoma passed per urethra. (11956472)
2002
28
Incomplete Beckwith-Wiedemann syndrome in a child with orbital rhabdomyosarcoma. (11910143)
2002
29
Usefulness of immunohistochemical testing and electron microscopy in the diagnosis of embryonal rhabdomyosarcoma. (11782672)
2002
30
Solid variant of alveolar rhabdomyosarcoma with unbalanced t(2;13) and hypotetraploidy, without MYCN amplification. (11280599)
2001
31
Gastric carcinosarcoma, coexistence of adenosquamous carcinoma and rhabdomyosarcoma: a case report. (11737318)
2001
32
Alveolar rhabdomyosarcoma of the parotid gland. (11320838)
2001
33
Alveolar rhabdomyosarcoma of paranasal sinus with cervical metastasis-a case report. (23119659)
2000
34
Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma. (10884376)
2000
35
Costello syndrome and rhabdomyosarcoma. (10424828)
1999
36
Genes, chromosomes, and rhabdomyosarcoma. (10534762)
1999
37
Polymerase chain reaction-based diagnosis of rhabdomyosarcomas: comparison of fetal type acetylcholine receptor subunits and myogenin. (9836066)
1998
38
Spindle cell rhabdomyosarcoma (so-called) in adults: report of two cases with emphasis on differential diagnosis. (9537474)
1998
39
MYCN gene amplification in rhabdomyosarcoma. (8156531)
1994
40
Pleomorphic rhabdomyosarcoma arising in association with the right pulmonary artery. (7979918)
1994
41
Embryonal rhabdomyosarcoma in a 7-month-old Sprague-Dawley rat. (8203098)
1994
42
Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. (7508822)
1994
43
Cytogenetic analysis of an embryonal rhabdomyosarcoma cell line. (1322234)
1992
44
Chromosome translocation (2;13)(q37;q14) in a disseminated alveolar rhabdomyosarcoma. (3197735)
1988
45
Long-term follow-up and complications of infants with vulvovaginal embryonal rhabdomyosarcoma treated with surgery, radiation therapy, and chemotherapy. (3347430)
1988
46
Alveolar rhabdomyosarcoma of the larynx: case report and literature review. (3546986)
1987
47
Multidisciplinary treatment of advanced stages of embryonal rhabdomyosarcoma in children. (7029285)
1981
48
Embryonal rhabdomyosarcoma (sarcoma botryoides) of the common bile duct: a case report. (992649)
1976
49
Embryonal rhabdomyosarcoma (botryoid type) of the vagina. A clinicopathologic review. (4915719)
1970
50
Embryonal rhabdomyosarcoma of the limbs and limb-girdles. A clinicopathologic study of 61 cases. (5786321)
1969

Genetic Variations for Rhabdomyosarcoma

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Expression for genes affiliated with Rhabdomyosarcoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rhabdomyosarcoma

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Pathways for genes affiliated with Rhabdomyosarcoma

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37NCBI BioSystems Database, 53Reactome
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Pathways related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.8FOXO3, FOXO1, FHL2
2
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10.7FOXO3, FOXO1

Compounds for genes affiliated with Rhabdomyosarcoma

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44Novoseek, 24HMDB
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Compounds related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glycogen44 2411.9TTN, IGF2, FOXO3, FOXO1

GO Terms for genes affiliated with Rhabdomyosarcoma

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16Gene Ontology
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Cellular components related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1M bandGO:03143010.7TTN, FHL2

Biological processes related to Rhabdomyosarcoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin receptor signaling pathwayGO:00828610.8IGF2, FOXO3, FOXO1
2spinal cord association neuron differentiationGO:02152710.7PAX7, PAX3
3neuron fate commitmentGO:04866310.6PAX7, PAX3
4tissue developmentGO:00988810.4FOXO3, FOXO1

Products for genes affiliated with Rhabdomyosarcoma

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Sources for Rhabdomyosarcoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet