Rhabdomyosarcoma malady

Wikipedia: A rhabdomyosarcoma is a type of cancer, specifically a sarcoma (cancer of connective tissues), in which...⁴⁴ more...

MalaCards: Rhabdomyosarcoma, also known as rhabdomyosarcoma, no subtype (morphologic abnormality), is related to alveolar rhabdomyosarcoma and pleomorphic rhabdomyosarcoma. An important gene associated with Rhabdomyosarcoma is FOXO1 (forkhead box O1), and among its related pathways are Cell cycle and Antioxidant Action of Vitamin-C. The drugs cyclophosphamide and dacarbazine and the compounds imatinib and calcium have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, smooth muscle and skeletal muscle, and related mouse phenotypes are growth/size and immune system.

Disease Ontology: A myosarcoma that arise from skeletal muscle progenitors.⁶

OMIM: 268210

Aliases & Descriptions:

rhabdomyosarcoma 6 7 8 33 32 43 rhabdomyosarcoma, no subtype (morphologic abnormality) 6 rhabdomyosarcoma nos (morphologic abnormality) 6

rhabdomyosarcoma (disorder) 6 rhabdomyoblastoma 6

Diseases related to rhabdomyosarcoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 853)

id	Related Disease	Score	Top Affiliating Genes
1	alveolar rhabdomyosarcoma	39.3	RB1, MYCN, MYOG, MYOD1, PAX7, PAX3
2	pleomorphic rhabdomyosarcoma	35.5	MYOG, MYOD1, PAX7, MUC16, MME, MB
3	sarcoma	35.2	NCAM1, NCOA1, NCOA3, KIT, KITLG, PCNA
4	botryoid rhabdomyosarcoma	34.6	MYOG, MYOD1, PAX7, PAX3, FOXO1, WT1
5	carcinoma	34.2	PIM2, NCAM1, NCOA1, NCOA3, SGCA, CNR1
6	orbit embryonal rhabdomyosarcoma	34.0	NCAM1, MYCN, MYOG, MYOD1, PAX7, PAX3
7	orbit rhabdomyosarcoma	33.9	VIM, MDM2, MB, ENO2, TP53, ABCB1
8	prostate rhabdomyosarcoma	32.2	CKB, CKM, CKMT1A, CKMT1B, CKMT2
9	nephroblastoma	32.1	NCAM1, KIT, VIM, PAX3, MVP, JUP
10	medulloblastoma	30.7	NCAM1, KIT, KIR2DS4, PCNA, RB1, NBN
11	melanoma	30.7	NCAM1, NCOA3, KIT, KITLG, KIR2DS4, PCNA
12	wilms tumor	30.4	NCAM1, KIR2DS4, PCNA, BUB1B, VIM, NAP1L4
13	osteosarcoma	30.3	NCOA1, CNR1, KIT, PCNA, RB1, VIM
14	leiomyosarcoma	30.2	KIT, PCNA, RB1, VIM, VEGFA, VCL
15	hypercalcemia	29.9	VIM, BMP6, B2M, FGFR3, IL6, CCND1
16	rhabdoid tumors	29.9	VIM, MYOD1, IGF1R, IGF2, PTPRC, SPP1
17	adrenocortical carcinoma	29.7	UTS2, CDKN1C, INHA, IGF1R, IGF2, IGFBP2
18	neuroblastoma	29.7	NCAM1, NCOA1, CNR1, KIT, KITLG, KIR2DS4
19	adenocarcinoma	29.5	PIM2, NCAM1, NCOA1, NCOA3, CNR1, KIT
20	angiosarcoma	29.5	KIT, KITLG, VIM, VEGFA, MYC, MYOG
21	sertoli-leydig cell tumor	29.4	VIM, MYOG, MUC16, INHA, ENO2, ESR1
22	leydig cell tumor	29.3	KIT, VIM, MYOG, MUC16, INHA, INSR
23	embryonal sarcoma	29.1	KIT, VIM, MYOG, MYOD1, S100B, CDK4
24	leukemia	28.9	PIM2, NCAM1, NCOA1, NCOA3, CNR1, KIT
25	hemihypertrophy	28.7	CDKN1C, INSR, IGF2, WT1, TH, H19
26	chondrosarcoma	28.7	RB1, VIM, VEGFA, VCL, MYOG, MYOD1
27	synovial sarcoma	28.6	KIT, VIM, MYCN, RARA, BCL2, S100B
28	malignant peripheral nerve sheath tumor	28.5	NCAM1, KIT, VIM, MYOG, S100A1, S100B
29	nevus	28.5	KIT, PCNA, VIM, BMP6, BCL2, S100A1
30	noonan syndrome	28.4	CDKN3, FGFR3, MAP2K2, MAPK1, IGF1, HRAS
31	dna topoisomerase ii	28.3	PCNA, MYC, BCL2L1, YBX1, CDKN1A, ERBB2
32	costello syndrome	28.3	INS, MB, MAP2K2, IGF2, IGF1, HRAS
33	fibrosarcoma	28.2	KIT, KITLG, RB1, VIM, VEGFA, MYOD1
34	small cell carcinoma	28.0	NCAM1, KIT, PCNA, RB1, VIM, VEGFA
35	soft tissue sarcoma	27.5	KIT, KITLG, PCNA, RB1, VIM, VEGFA
36	clear cell adenocarcinoma	27.2	MUC16, PTHLH, SMAD4, KLK3, SLC2A4
37	myasthenia gravis	26.2	NCAM1, MYOZ2, MYF6, BCL2, CD55, MMP2
38	retinoblastoma	26.1	NCAM1, KIT, KITLG, PCNA, RB1, NBN
39	ataxia telangiectasia	24.8	PCNA, NBN, VIM, MYC, BCL2, BAX
40	ataxia	24.2	PIM2, PCNA, NBN, VIM, MYC, RARA
41	acute leukemia	24.0	NCAM1, KIT, KITLG, RB1, VEGFA, MYC
42	cutaneous malignant melanoma	23.8	KIT, KIR2DS4, PCNA, VEGFA, MYC, PAX7
43	sinusitis	23.7	PCNA, VIM, VEGFA, MYC, MYOG, BMP6
44	nasopharyngitis	23.4	NCOA3, KIT, KITLG, PCNA, RB1, NBN
45	prostatitis	15.7	PIM2, NCAM1, NCOA1, NCOA3, SGCA, CNR1
46	desmoplastic small round cell tumor	15.4	KIT, VIM, MYOG, MYF5, MYOD1, BMP4
47	beckwith-wiedemann syndrome	15.1	NAP1L4, MYOD1, CDKN1C, INS, GPC3, IGF1R
48	duchenne muscular dystrophy	15.1	SGCA, VCL, MYOZ2, MYOD1, CKM, MSTN
49	ganglioglioma	15.0	MYCN, BCL2L1, MVP, S100B, ENO2, TP53
50	hypertrophy of breast	14.9	VCL, MYOG, MYOZ2, MYF6, MYOD1, BMP4

Clinical features from OMIM: 268210

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cyclophosphamide, dacarbazine, dactinomycin, etoposide, etoposide phosphate, melphalan, melphalan hydrochloride, vincristine, vincristine sulfate

MalaCards organs/tissues related to rhabdomyosarcoma:

²²

MGI Mouse Phenotypes related to rhabdomyosarcoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size phenotype	MP:0005378	INF	PIM2, NCOA1, NCOA3, CNR1, , KITLG
2	immune system phenotype	MP:0005387	INF	PIM2, NCOA1, NCOA3, SGCA, ,
3	cellular phenotype	MP:0005384	INF	PIM2, NCAM1, NCOA3, CNR1, , KITLG
4	homeostasis/metabolism phenotype	MP:0005376	INF	NCOA1, NCOA3, SGCA, CNR1, , KITLG
5	integument phenotype	MP:0010771	INF	NCOA1, NCOA3, CNR1, , KITLG,
6	hematopoietic system phenotype	MP:0005397	INF	PIM2, , PCNA, , NBN, LMO4
7	skeleton phenotype	MP:0005390	INF	NCOA1, CNR1, , KITLG, , RB1
8	muscle phenotype	MP:0005369	INF	NCOA3, SGCA, , , RB1, VIM
9	adipose tissue phenotype	MP:0005375	INF	NCOA3, CNR1, , RB1, MYC, MYOG
10	craniofacial phenotype	MP:0005382	INF	NCOA3, , KITLG, NBN, BOC, LMO4
11	renal/urinary system phenotype	MP:0005367	INF	NCOA1, NCOA3, , MYCN, BMP4, RARA
12	liver/biliary system phenotype	MP:0005370	INF	NCOA3, , VEGFA, MYCN, BMP4, BID
13	tumorigenesis	MP:0002006	INF	NCOA3, , KITLG, , RB1, NBN
14	hearing/vestibular/ear phenotype	MP:0005377	INF	NCOA3, , KITLG, RB1, LMO4, MYC
15	no phenotypic analysis	MP:0003012	10.4	CNR1, PCNA, RB1, VEGFA, MYC, MYF5
16	other phenotype	MP:0005395	10.2	CNR1, MYF5, RARA, RARB, CLU, CDKN2A
17	embryogenesis phenotype	MP:0005380	INF	NCOA1, NCOA3, , , NBN, VIM
18	digestive/alimentary phenotype	MP:0005381	INF	NCOA3, , KITLG, RB1, VEGFA, VCL
19	reproductive system phenotype	MP:0005389	INF	NCOA1, NCOA3, , NBN, VEGFA, MYCN
20	respiratory system phenotype	MP:0005388	INF	BOC, MYCN, MYOG, MYF5, MYF6, MYOD1
21	mortality/aging	MP:0010768	INF	NCAM1, CNR1, KITLG, RB1, VEGFA, VCL
22	normal phenotype	MP:0002873	INF	VEGFA, BOC, MYC, MYOG, MYF5, MYF6
23	behavior/neurological phenotype	MP:0005386	INF	NCAM1, NCOA1, NCOA3, CNR1, , RB1
24	vision/eye phenotype	MP:0005391	INF	NCAM1, , KITLG, , RB1, VIM
25	limbs/digits/tail phenotype	MP:0005371	INF	, KITLG, RB1, VEGFA, VCL, BOC
26	nervous system phenotype	MP:0003631	INF	NCOA1, CNR1, , KITLG, RB1, NBN
27	cardiovascular system phenotype	MP:0005385	INF	SGCA, , KITLG, RB1, VIM, VEGFA
28	endocrine/exocrine gland phenotype	MP:0005379	INF	NCOA1, NBN, PAX7, PAX3, KDM1A, FUS
29	pigmentation phenotype	MP:0001186	INF	, KITLG, RB1, MYC, PAX3, BCL2

Articles related to rhabdomyosarcoma:

(show top 50)    (show all 424)

id	Title	Authors	Year	Affiliating Genes
1	IL-4R drives dedifferentiation, mitogenesis, and meta stasis in rhabdomyosarcoma. (21536546)	Hosoyama T.... Keller C.	2011	IL4R
2	PAX3-FOXO1 and FGFR4 in alveolar rhabdomyosarcoma. (21882254)	Marshall A.D.... Grosveld G.C.	2011	FGFR4
3	Pleomorphic rhabdomyosarcoma showing smooth-muscle an d fibrohistiocytic differentiation: a single case report. (20070153)	Eyden B.	2010	MYOD1, MYOG
4	Fusion gene-negative alveolar rhabdomyosarcoma is cli nically and molecularly indistinguishable from embryonal rhabdomyosarcoma. (20351326)	Williamson D.... Delattre O.	2010	PAX3, PAX7, FOXO1
5	The utility of FOXO1 fluorescence in situ hybridizati on (FISH) in formalin-fixed paraffin-embedded specimens in the diagnosis of alv eolar rhabdomyosarcoma. (19704258)	Downs-Kelly E.... Goldblum J.R.	2009	FOXO1
6	Small interfering RNA library screen of human kinases and phosphatases identifies polo-like kinase 1 as a promising new target for t he treatment of pediatric rhabdomyosarcomas. (19887553)	Hu K.... Dunn S.E.	2009	PLK1
7	Rhabdomyosarcoma in patients with constitutional mism atch-repair-deficiency syndrome. (19293170)	Kratz C.P.... Wimmer K.	2009	MSH2, MSH6, PMS2
8	E-cadherin, b-catenin and topoisomerase II expression in rhabdomyosarcomas. (19650189)	Gogou P.N.... Tsekeris P.G.	2009	CDH1, CTNNB1
9	Rhabdomyosarcoma of the urinary bladder in adults: predilection for alveolar morphology with anaplasia and significant morphologic overlap with small cell carcinoma. (18469707)	Paner G.P.... Amin M.B.	2008	MYOG
10	Clinicopathologic analysis of spindle cell rhabdomyosarcoma: report of 8 cases (18646700)	Zhang H.T.... Su Q.	2008	DES
11	Diffuse myogenin expression by immunohistochemistry is an independent marker of poor survival in pediatric rhabdomyosarcoma: a tissue microarray study of 71 primary tumors including correlation with molecular phenotype. (18708938)	Heerema-McKenney A.... Linn S.C.	2008	BCL2, CD44, MYOD1
12	Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype. (18386058)	Kohashi K.... Tsuneyoshi M.	2008	RB1
13	Polypoid angiomyofibroblastoma-like tumor of the oral cavity: a hitherto unreported soft tissue tumor mimicking embryonal rhabdomyosarcoma. (18656317)	Magro G.... Ninfo V.	2008	DES, MYOD1, MYOG
14	RAGE expression in rhabdomyosarcoma cells results in myogenic differentiation and reduced proliferation, migration, invasiveness, and tumor growth. (17640970)	Riuzzi F.... Donato R.	2007	AGER
15	FGFR1 over-expression in primary rhabdomyosarcoma tumors is associated with hypomethylation of a 5' CpG island and abnormal expression of the AKT1, NOG, and BMP4 genes. (17696196)	Goldstein M.... Orr-Urtreger A.	2007	FGFR1, AKT1, BMP4
16	Uniparental disomy at chromosome 11p15.5 followed by HRAS mutations in embryonal rhabdomyosarcoma: lessons from Costello syndrome. (17164262)	Kratz C.P.... Zenker M.	2007	HRAS
17	Sequential recruitment of PCAF and BRG1 contributes to myogenin activation in 12-O-tetradecanoylphorbol-13-acetate-induced early differentiation of rhabdomyosarcoma-derived cells. (17468105)	Li Z.Y.... Shen Y.F.	2007	MAPK14, SMARCA4, KAT2B
18	Defining the gene expression signature of rhabdomyosarcoma by meta-analysis. (17090319)	Romualdi C.... Lanfranchi G.	2006	SAGE1
19	p53 family members in myogenic differentiation and rhabdomyosarcoma development. (17045206)	Cam H.... Stiewe T.	2006	RB1, CDKN1C, TP73
20	Gene expression profiling identifies potential relevant genes in alveolar rhabdomyosarcoma pathogenesis and discriminates PAX3-FKHR positive and negative tumors. (16381018)	De Pitta C.... Rosolen A.	2006	CCND1, IGFBP2
21	An immunohistochemical algorithm to facilitate diagnosis and subtyping of rhabdomyosarcoma: the Children's Oncology Group experience. (16861966)	Morotti R.A.... Qualman S.J.	2006	MYOD1, MYOG
22	Upstream CpG island methylation of the PAX3 gene in human rhabdomyosarcomas. (15602708)	Kurmasheva R.T.... Cooney C.A.	2005	PAX3
23	Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells). (15997097)	Kobayashi M.... Iseki K.	2005	SLC16A1, SLC16A7, SLC16A4
24	Caveolin-3 is a sensitive and specific marker for rhabdomyosarcoma. (16082247)	Fine S.W.... Li M.	2005	MYOD1, CAV3, MYOG
25	Multimodal genetic diagnosis of solid variant alveolar rhabdomyosarcoma. (16337856)	Cerveira N.... Teixeira M.R.	2005	PAX7
26	Rhabdomyosarcoma: value of myogenin expression analysis and molecular testing in diagnosing the alveolar subtype: an analysis of 109 paraffin-embedded specimens. (15536621)	Hostein I.... Coindre J.M.	2004	MYOG
27	Fragile histidine triad expression in rhabdomyosarcoma (15071908)	Wang S.L.... Ye L.	2004	FHIT
28	Influence of casein kinase II in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human rhabdomyosarcoma cells. (15475455)	Izeradjene K.... Houghton J.A.	2004	TNFRSF10B, TNFSF10, CSNK2A2
29	Sclerosing rhabdomyosarcomas in children and adolescents: a clinicopathologic review of 13 cases from the Intergroup Rhabdomyosarcoma Study Group and Children's Oncology Group. (15630526)	Chiles M.C.... Meyer W.H.	2004	MYOD1, MYOG
30	Congenital primary cutaneous rhabdomyosarcoma in a neonate. (12869157)	Brecher A.R.... Chang M.W.	2003	MYOG
31	Overexpression of the immunoglobulin superfamily members CDO and BOC enhances differentiation of the human rhabdomyosarcoma cell line RD. (12720294)	Wegorzewska M.... Kang J.S.	2003	CDON, BOC
32	Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. (12783965)	Sebire N.J.... Malone M.	2003	MYOD1, MYOG
33	PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells. (12865925)	Tiffin N.... Pritchard-Jones K.	2003	PAX7
34	Sclerosing rhabdomyosarcoma in adults: report of four cases of a hyalinizing, matrix-rich variant of rhabdomyosarcoma that may be confused with osteosarcoma, chondrosarcoma, or angiosarcoma. (12218574)	Folpe A.L.... Weiss S.W.	2002	DES, MYOD1, MYOG
35	HER/erbB receptors as therapeutic targets of immunotoxins in human rhabdomyosarcoma cells. (12142554)	Ricci C.... Lollini P.L.	2002	ERBB3
36	Induction of terminal differentiation by the c-Jun dimerization protein JDP2 in C2 myoblasts and rhabdomyosarcoma cells. (12171923)	Ostrovsky O.... Aronheim A.	2002	JDP2
37	Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization and fluorescence in situ hybridization: an intergroup rhabdomyosarcoma study. (10719362)	Bridge J.A.... Suijkerbuijk R.	2000	PTCH1
38	Evaluation of new monoclonal anti-MyoD1 and anti-myogenin antibodies for the diagnosis of rhabdomyosarcoma. (10227726)	Cui S.... Ushigome S.	1999	MYOD1, MYOG
39	Detection of MDM 2 and p 53 genes in rhabdomyosarcoma by in situ hybridization (11244964)	Lai R.... Zhe X.	1998	MDM2
40	Effective schedules of exposure of medulloblastoma and rhabdomyosarcoma xenografts to topotecan correlate with in vitro assays. (9717830)	Pawlik C.A.... Danks M.K.	1998	TOP1
41	Recurrent rhabdomyosarcoma after 25 years: a possible association with estrogen and progestogen therapy. (9329475)	Zacharin M.... McKelvie P.	1997	PGR
42	Subtractive cloning and characterization of DRAL, a novel LIM-domain protein down-regulated in rhabdomyosarcoma. (9150430)	Genini M.... Schaefer B.W.	1997	FHL2
43	In vivo amplification of the PAX3-FKHR and PAX7-FKHR fusion genes in alveolar rhabdomyosarcoma. (8789435)	Barr F.G.... Biegel J.A.	1996	PAX7
44	Desmin expression in rhabdomyosarcoma: influence of the desmin clone and immunohistochemical method. (7665696)	Pollock L.... Malone M.	1995	DES
45	Transglutaminase-catalyzed cross-linking of fibrils of collagen V/XI in A204 rhabdomyosarcoma cells. (7577969)	Kleman J.P.... van der Rest M.	1995	LOX
46	The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3. (7862145)	Fredericks W.J.... Rauscher F.J.	1995	PAX3, FOXO1
47	The expression pattern of contractile and intermediate filament proteins in developing skeletal muscle and rhabdomyosarcoma of childhood: diagnostic and prognostic utility. (7884590)	Wijnaendts L.C.... Meijer C.J.	1994	VIM, DES, ACTC1
48	Rearrangement of the PAX3 paired box gene in the paediatric solid tumour alveolar rhabdomyosarcoma. (8098985)	Barr F.G.... Emanuel B.S.	1993	PAX3
49	Infantile rhabdomyofibrosarcoma: a high-grade sarcoma distinguishable from infantile fibrosarcoma and rhabdomyosarcoma. (8319957)	Lundgren L.... Kindblom L.G.	1993	VIM, DES, ACTC1
50	Immunohistochemical study of childhood rhabdomyosarcomas and related neoplasms. Results of an Intergroup Rhabdomyosarcoma study project. (1710539)	Parham D.M.... Maurer H.	1991	ENO2, DES, MB

Genes related to rhabdomyosarcoma according to GeneCards:

(show top 50)    (show all 344)

id	Symbol	Description	Score	GeneCards Section Context
1	FOXO1	forkhead box O1	11.1	Summaries, Publications, Aliases & Descriptions
2	FHL2	four and a half LIM domains 2	11.1	Summaries, Publications, Functions, Aliases & Descriptions
3	PAX3	paired box 3	11.1	Summaries, Publications, Functions
4	PAX7	paired box 7	11.1	Summaries, Publications
5	FOXO3	forkhead box O3	11.0	Aliases & Descriptions, Publications
6	IGF2	insulin-like growth factor 2 (somatomedin A)	11.0	Summaries, Publications
7	PPP2R3C	protein phosphatase 2, regulatory subunit B'', gamma	11.0	Aliases & Descriptions
8	SLC22A18	solute carrier family 22, member 18	11.0	Summaries
9	XAGE1C	X antigen family, member 1C	11.0	Summaries, Expressions
10	XAGE1D	X antigen family, member 1D	11.0	Expressions, Summaries
11	XAGE1E	X antigen family, member 1E	11.0	Summaries, Expressions
12	XAGE1A	X antigen family, member 1A	11.0	Summaries, Expressions
13	XAGE1B	X antigen family, member 1B	11.0	Expressions, Summaries
14	STIM1	stromal interaction molecule 1	11.0	Publications, Functions, Summaries
15	TTN	titin	11.0	Aliases & Descriptions, Publications
16	PMS1	PMS1 postmeiotic segregation increased 1 (S. cerevisiae)	11.0	Aliases & Descriptions
17	CARS	cysteinyl-tRNA synthetase	11.0	Summaries
18	FOXO1B	forkhead box O1B pseudogene	11.0	Aliases & Descriptions
19	FOXO3B	forkhead box O3B pseudogene	11.0	Aliases & Descriptions
20	RMST	rhabdomyosarcoma 2 associated transcript (non-protein coding)	11.0	Aliases & Descriptions, Publications, Transcripts
21	CCDC99	coiled-coil domain containing 99	11.0	Aliases & Descriptions
22	BRD9	bromodomain containing 9	11.0	Aliases & Descriptions
23	TCEA3	transcription elongation factor A (SII), 3	11.0	Aliases & Descriptions
24	RPS18	ribosomal protein S18	11.0	Aliases & Descriptions
25	MYH7	myosin, heavy chain 7, cardiac muscle, beta	11.0	Aliases & Descriptions
26	DES	desmin	11.0	Publications
27	MYOG	myogenin (myogenic factor 4)	11.0	Publications
28	MB	myoglobin	11.0	Publications
29	MYOD1	myogenic differentiation 1	11.0	Publications
30	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications
31	MYCN	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)	11.0	Publications
32	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1	11.0	Publications
33	WT1	Wilms tumor 1	11.0	Publications
34	VIM	vimentin	11.0	Publications
35	CDK4	cyclin-dependent kinase 4	11.0	Publications
36	IGF1R	insulin-like growth factor 1 receptor	11.0	Publications
37	XAGE2	X antigen family, member 2	11.0	Summaries
38	TSSC4	tumor suppressing subtransferable candidate 4	11.0	Summaries
39	PHLDA2	pleckstrin homology-like domain, family A, member 2	11.0	Summaries
40	TSPAN32	tetraspanin 32	11.0	Summaries
41	NAP1L4	nucleosome assembly protein 1-like 4	11.0	Summaries
42	RRM1	ribonucleotide reductase M1	11.0	Summaries
43	NUP98	nucleoporin 98kDa	11.0	Summaries
44	PTCH1	patched 1	11.0	Publications
45	TSSC1	tumor suppressing subtransferable candidate 1	11.0	Summaries
46	ACTC1	actin, alpha, cardiac muscle 1	11.0	Publications
47	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
48	RB1	retinoblastoma 1	11.0	Publications
49	NCAM1	neural cell adhesion molecule 1	11.0	Publications
50	TP53	tumor protein p53	11.0	Publications

Pathways related to rhabdomyosarcoma according to GeneDecks:

(show top 50)    (show all 366)

id	Pathway	Score	Top Affiliating Genes
1	Cell cycle20	INF	PCNA, , RB1, MYC, YWHAG, YWHAZ
2	Antioxidant Action of Vitamin-C36	INF	, KITLG, BMP4, BMP6, UTS2, BCL2
3	Pancreatic Adenocarcinoma36	INF	, KITLG, RB1, BMP4, BMP6, UTS2
4	Melanoma20	11.4	RB1, CDK6, CDKN1A, CDKN2A, CDK4, CDH1
5	Glioma20	11.4	RB1, MTOR, CDK6, CDKN1A, CDKN2A, CDK4
6	Breast Cancer Regulation by Stathmin136	11.3	BMP4, UTS2, FGFR3, FGFR4, MAP2K2, MAP2K4
7	Development_Ligand-independent activation of ESR1 and ESR241	11.3	NCOA1, NCOA3, IRS1, MAP2K2, MAPK3, CCND1
8	Development_Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis41	11.3	MYOG, MYF6, MYOD1, YWHAG, YWHAZ, MTOR
9	Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis10	11.1	MYOG, MYF6, MYOD1, YWHAG, YWHAZ, KAT2B
10	ErbB2-ErbB3 Heterodimers36	11.1	FOXO3, MAP2K2, MAP2K4, ERBB3, ERBB2, RPS6KB1
11	Signal transduction AKT signaling10	11.0	IRS1, PDPK1
12	Pancreatic cancer20	10.9	CDK6
13	Rac1 Pathway36	10.8	KITLG, BMP4, BMP6, UTS2, CFL1, ITGA2
14	Endometrial cancer20	10.6	MYC, CDH1, ILK, MAP2K2, MAPK3, MAPK1
15	Chronic myeloid leukemia20	10.6	RB1, MYC, BCL2L1, CDK6, CDKN1A, CDKN2A
16	Prostate cancer20	10.5	RB1, BCL2, MTOR, CDKN1A, FOXO1, INS
17	Transcription Receptor-mediated HIF regulation10	10.4	IRS1, INS, INSR, MAPK3, MAPK1, IGF1R
18	p53 Signaling36	10.4	BCL2, BAX, ATM, CDKN1A, CDK4, FOS
19	Rap1 Pathway36	10.4	KITLG, BMP4, BMP6, UTS2, ITGA2, ITGA3
20	Transcription P53 signaling pathway10	10.3	VEGFA, KAT2B, CDKN2A, FHL2, APEX1, MAPK8
21	Transcription_Receptor-mediated HIF regulation41	10.2	VEGFA, MTOR, IRS1, INS, INSR, MAP2K2
22	Bladder cancer20	9.8	RB1, VEGFA, MYC, CDKN1A, CDKN2A, CDK4
23	Transcription_P53 signaling pathway41	9.6	RB1, VEGFA, BCL2, ATM, KAT2B, CDKN1A
24	TGF-Beta Pathway36	9.5	KITLG, BMP4, BMP6, UTS2, BCL2, BAX
25	Glucocorticoid Receptor Signaling36	8.6	NCOA1, NCOA3, BMP4, BMP6, BCL2, BAX
26	Molecular Mechanisms of Cancer36	INF	KITLG, RB1, MYC, BMP4, BMP6, RARA
27	Akt Signaling36	INF	, BMP4, UTS2, ITGA2, FOXO1, IRS1
28	ILK Signaling36	INF	, KITLG, VIM, BMP4, UTS2, CFL1
29	PPAR Pathway36	INF	NCOA1, , KITLG, BMP4, UTS2, ITGA2
30	ERK Signaling36	INF	, KITLG, MYC, BMP4, BMP6, UTS2
31	Apoptosis Signaling Pathways37	INF	BID, BCL2, BCL2L1, YWHAG, YWHAZ, BAX
32	Signal transduction_AKT signaling41	INF	PCNA, MYC, BCL2L1, BAX, MTOR, CDKN1A
33	Intracellular Calcium Signaling36	INF	, KITLG, BMP4, BMP6, UTS2, INSR
34	Apoptotic Pathways in Synovial Fibroblasts36	INF	, KITLG, BMP4, BMP6, UTS2, FGFR1
35	Acute myeloid leukemia20	INF	PIM2, , MYC, RARA, MTOR, JUP
36	Cellular Apoptosis Pathway36	INF	, KITLG, BMP4, BMP6, UTS2, BID
37	Paxillin Interactions36	INF	, KITLG, VCL, BMP4, UTS2, ITGA2
38	Development_IGF-1 receptor signaling41	INF	MYC, BCL2L1, YWHAZ, MTOR, FOXO3, IRS1
39	Tec Kinases Signaling36	INF	KITLG, BMP4, BMP6, UTS2, BCL2, BAX
40	Focal adhesion20	INF	VCL, BCL2, ITGA2, ITGA3, MET, ILK
41	Estrogen Pathway36	INF	NCOA1, NCOA3, , KITLG, BMP4, BMP6
42	p53 signaling pathway20	INF	BID, BAX, ATM, CDK6, CDKN1A, CDKN2A
43	JAK-STAT Pathway36	INF	, KITLG, MYC, BMP4, BMP6, UTS2
44	ERK5 Signaling36	INF	, KITLG, MYC, BMP4, BMP6, UTS2
45	P2Y Receptor Signaling36	INF	, MYC, FOS, INSR, FGFR1, FGFR3
46	p53 Mediated Apoptosis36	INF	, KITLG, BMP4, BMP6, UTS2, BID
47	CDC42 Pathway36	INF	, CFL1, CDH1, ITGA2, ITGA3, FOS
48	Endothelin-1 Signaling Pathway36	INF	, MYC, BMP4, BMP6, INSR, FGFR3
49	Development IGF-RI signaling10	INF	MYC, BCL2L1, MTOR, FOXO3, IRS1, MAPK3
50	p70S6K Signaling36	INF	, KITLG, BMP4, BMP6, UTS2, YWHAG

Compounds related to rhabdomyosarcoma according to GeneDecks:

(show top 50)    (show all 398)

id	Compound	Score	Top Affiliating Genes
1	imatinib32 34 9 9	INF	, KITLG, VEGFA, MYC, BMP6, RARA
2	calcium32 9 18 9	INF	CNR1, , KITLG, RB1, VCL, MYL6
3	methotrexate32 34 42 9 9	INF	, KITLG, PCNA, RB1, VIM, BMP6
4	heparin32 9 18 9	15.2	NCAM1, KITLG, VIM, NAP1L4, VCL, BMP4
5	bromodeoxyuridine32	12.0	NCAM1, NCOA3, KITLG, PCNA, RB1, VIM
6	proline32	11.4	VIM, VCL, CLU, S100B, MSH2, CDK6
7	fatty acid32	11.4	NCOA1, MYOG, MYOD1, CLU, CDKN2A, CD55
8	gnrh32	11.2	NCAM1, KITLG, VIM, CHRM2, CGB7, MME
9	guanine32 9 18 9	14.1	CNR1, MYOD1, CHRM2, MGMT, FGFR3, IL4R
10	egcg32	10.9	BCL2L1, CDK6, MCL1, MAPK8, MAPK3, MAPK14
11	pge232	10.9	BMP4, CDH1, MME, MB, IGF1R, LOX
12	progestin32	10.7	VIM, VEGFA, CDK6, CDK4, CDH1, INSR
13	dmso32	10.6	KITLG, VIM, BMP6, INSR, MEF2A, APOB
14	ibmx32	10.5	RARB, CDKN3, MME, MMP2, IRS1, INS
15	crcs32	10.4	RB1, CEACAM5, MSH2, MSH6, CDKN2A, CDH1
16	cholesterol32 9 18 9	13.4	NCOA1, KITLG, RB1, UTS2, CLU, PAX5
17	carboplatin32 34 9 9	13.1	KITLG, RB1, VEGFA, BID, BCL2, MUC16
18	sulindac32 9 9	11.9	PCNA, BCL2, BCL2L1, BAX, CDKN1A, CDH1
19	taxane32	9.7	VEGFA, BCL2, MTOR, CDKN1A, ESR1, ERBB2
20	thymidylate32	9.2	PCNA, RB1, VIM, VEGFA, BCL2, BCL2L1
21	5-aza-2deoxycytidine32	9.0	KITLG, PCNA, VIM, MYC, MYOD1, BMP6
22	pdtc32	8.7	BCL2, BCL2L1, CDKN1A, MMP2, FOS, MET
23	herbimycin a32 42	9.7	KITLG, MYC, BMP6, CDK6, CDKN3, CDK4
24	calcitriol32 42 9 18 9	12.5	NCOA1, NCOA3, KITLG, RB1, MYC, BMP6
25	cysteine32	INF	KIR2DS4, PCNA, VCL, MYOG, BMP4, RARA
26	vitamin d32	INF	NCOA1, NCOA3, VIM, BMP6, RARA, RARB
27	nitric oxide32 9 18 9	INF	NCAM1, , KITLG, RB1, VCL, MYCN
28	17-(allylamino)-17-demethoxygeldanamycin32	INF	, CDK6, CDKN1A, CDK4, CDH1, CCND1
29	aspartate32	INF	CNR1, PCNA, VIM, BMP6, RARA,
30	hematoxylin32	INF	NCAM1, , PCNA, VIM, MUC16, S100A1
31	phosphotyrosine32	INF	, JUP, CDKN3, CDH1, MMP14, FOS
32	atp32	INF	NCAM1, , RB1, VCL, MYOD1, CLU
33	leucine32	INF	NCOA1, , RB1, VIM, MYC, MYCN
34	cyclic amp32 18	INF	NCOA1, CNR1, RB1, VCL, MYOD1, RARB
35	tamoxifen32 34 9 9	INF	NCOA1, NCOA3, PCNA, VIM, VEGFA, MYC
36	vincristine32 34 9 9	INF	NCAM1, , MYCN, MGMT, MAP2K4, MAPK3
37	resveratrol32 9 18 9	INF	PCNA, RB1, VEGFA, BID, BCL2, BCL2L1
38	12-o-tetradecanoylphorbol 13-acetate32	INF	NCAM1, RB1, VCL, MYC, MYOG, MYOD1
39	paclitaxel32 34 9 9	INF	, KITLG, PCNA, , RB1, VIM
40	okadaic acid32 42	INF	RB1, VIM, VCL, MYC, BMP6, BCL2
41	adpribose32	INF	PCNA, RB1, BID, BCL2L1, BAX, CDKN1A
42	p00232	INF	, RB1, MVP, CEACAM5, JUP, CD44
43	tgf beta132	INF	KITLG, VIM, MYOD1, BMP4, BMP6, RARA
44	cytarabine32 34 9 9	INF	, KITLG, PCNA, RB1, VIM, MYC
45	glucose32	INF	, VCL, MYOG, MYOD1, UTS2R, BID
46	thapsigargin32 42	INF	CNR1, PCNA, UTS2, BCL2, BCL2L1, CDKN3
47	2-methoxyestradiol32 18	INF	PCNA, BID, PAX5, BCL2, BCL2L1, BAX
48	flavopiridol32 9 9	INF	, RB1, VEGFA, BID, BCL2, BCL2L1
49	vinblastine32 9 9	INF	, VIM, BCL2, BCL2L1, MVP, BAX
50	gp 13032	INF	, MYOD1, BMP4, BMP6, BCL2L1, IL15

Cellular components related to rhabdomyosarcoma according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	TNFSF14, TERT, PTHLH, PTPN11, SUFU, DDX1
2	nucleus	GO:005634	INF	CALCA, APEX1, MDM2, IL15, MEF2A, FGFR4
3	plasma membrane	GO:005886	INF	TNF, TNFRSF10B, TNFSF13B, TNFSF14, PTCH1, PTPRC
4	nucleoplasm	GO:005654	11.2	PGR, TP53, ESR2, ESR1, AKT1, CARM1
5	protein complex	GO:043234	10.8	DMD, EIF4EBP1, ACTA2, TCF3, SYP, PRKCA
6	extracellular region	GO:005576	9.8	CYR61, SPP1, CTGF, PLAUR, NOG, PTHLH
7	cytosol	GO:005829	INF	PSMA2, CTGF, ODC1, DICER1, , DMD
8	cell surface	GO:009986	INF	RPS6KB1, PLAUR, DMD, TNF, ABCB1,
9	extracellular space	GO:005615	INF	PTHLH, PTH, TNFSF14, TNFSF13B, TNFSF10, TNF
10	cyclin-dependent protein kinase holoenzyme complex	GO:000307	INF	CCND1, , CCNE1, CDK4, CDKN1A, CDK6
11	integral to plasma membrane	GO:005887	INF	ABCC1, , AGER, TSPAN31, PDGFRB, PDGFRA

Biological processes related to rhabdomyosarcoma according to GeneDecks:

(show top 50)    (show all 91)

id	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:006915	INF	, NBN, VIM, BID, PAX3, BCL2
2	virus-host interaction	GO:019048	11.3	RB1, VIM, BAX, KAT2B, CD247, ITGA2
3	muscle filament sliding	GO:030049	11.2	VIM, TNNI1, DMD, ACTC1, TTN, DES
4	positive regulation of muscle cell differentiation	GO:051149	11.2	BOC, MYOG, MYF5, MYF6, MYOD1, CDON
5	muscle cell differentiation	GO:042692	11.1	BOC, MYOG, MYF5, MYF6, MYOD1, CDON
6	epidermal growth factor receptor signaling pathway	GO:007173	11.1	MTOR, FOXO1, FOXO3, MDM2, AP2B1, MAP2K2
7	axon guidance	GO:007411	11.0	NCAM1, BOC, CFL1, CDH4, ITGA2, FGFR1
8	nerve growth factor receptor signaling pathway	GO:048011	11.0	MTOR, FOXO1, FOXO3, IRS1, MEF2A, MDM2
9	blood coagulation	GO:007596	11.0	VEGFA, VCL, CLU, KDM1A, YWHAZ, CFL1
10	insulin receptor signaling pathway	GO:008286	10.9	MTOR, FOXO1, IRS1, INS, INSR, FGFR1
11	G1/S transition of mitotic cell cycle	GO:000082	10.9	PIM2, PCNA, RB1, BCL2, CDK6, CDKN1A
12	positive regulation of fibroblast proliferation	GO:048146	10.8	MYC, UTS2, UTS2R, CDK6, CDKN1A, CDK4
13	negative regulation of transcription from RNA polymerase II promoter	GO:000122	10.7	MYC, BMP4, RARB, PAX5, KDM1A, YBX1
14	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.7	BMP4, CD44, MIF, FGFR3, FGFR4, MAPK3
15	response to estradiol stimulus	GO:032355	10.6	NCOA1, BMP4, RARA, BID, INSR, ENO2
16	G1 phase of mitotic cell cycle	GO:000080	10.6	RB1, CDK6, CDKN1A, CDKN2C, CDKN2B, CDKN2A
17	germ cell development	GO:007281	10.6	BMP4, BCL2L1, BAX, MTOR, MSH2, AKT1
18	response to ethanol	GO:045471	10.5	CNR1, BCL2, MSTN, INSR, MGMT, IL4
19	response to virus	GO:009615	10.5	PIM2, CLU, CHRM2, CFL1, CDK6, GTF2F1
20	gene expression	GO:010467	10.5	MYC, RARA, RARB, YWHAZ, YBX1, KAT2B
21	positive regulation of DNA replication	GO:045740	10.4	KITLG, INS, INSR, MET, IGF1R, IGF1
22	positive regulation of cell migration	GO:030335	10.2	VEGFA, MMP14, FOXF1, IRS1, INS, INSR
23	cell cycle arrest	GO:007050	10.2	RB1, NBN, MYC, MSH2, ATM, KAT2B
24	positive regulation of apoptotic process	GO:043065	10.2	NCOA1, CNR1, BMP4, RARB, BID, CLU
25	activation of pro-apoptotic gene products	GO:008633	10.2	MYC, BID, BCL2, BAX, MAPK8, CASP8
26	release of cytochrome c from mitochondria	GO:001836	10.0	MYC, BID, CLU, BCL2, BCL2L1, BAX
27	platelet activation	GO:030168	10.0	VEGFA, VCL, CLU, YWHAZ, CFL1, IL6
28	positive regulation of glycogen biosynthetic process	GO:045725	10.0	IRS1, INS, INSR, IGF2, IGF1, AKT1
29	anti-apoptosis	GO:006916	10.0	PIM2, PAX7, BCL2, BCL2L1, YWHAZ, CFL1
30	positive regulation of MAP kinase activity	GO:043406	9.7	KITLG, VEGFA, FGFR1, ILK, ERBB2, TNF
31	response to drug	GO:042493	9.7	NBN, MYC, UTS2, UTS2R, BCL2, MVP
32	peptidyl-serine phosphorylation	GO:018105	9.6	BCL2, MTOR, ATM, ILK, MAPK8, MAPK14
33	MAPK cascade	GO:000165	9.4	MYC, INS, FGFR1, FGFR3, MEF2A, MAP2K2
34	negative regulation of apoptotic process	GO:043066	8.7	VEGFA, MYC, BMP4, CLU, KDM1A, BCL2
35	negative regulation of cell proliferation	GO:008285	INF	PIM2, BMP4, RARB, KAT2B, CDK6, CDKN1A
36	positive regulation of protein phosphorylation	GO:001934	INF	VEGFA, BMP4, MTOR, INSR, MAPK3,
37	protein phosphorylation	GO:006468	INF	PIM2, MYOD1, RARA, MTOR, CDK6, CDK9
38	phosphatidylinositol-mediated signaling	GO:048015	INF	PCNA, , MTOR, FOXO1, FOXO3, IRS1
39	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	NCOA1, NCOA3, RB1, VEGFA, LMO4, MYC
40	induction of apoptosis by intracellular signals	GO:008629	INF	MYC, BID, CLU, BCL2, BCL2L1, BAX
41	positive regulation of cell proliferation	GO:008284	INF	, NBN, VEGFA, MYC, RARA, BCL2L1
42	fibroblast growth factor receptor signaling pathway	GO:008543	INF	MTOR, , FOXO1, FOXO3, FGFR1, FGFR3
43	cell proliferation	GO:008283	INF	PIM2, KITLG, PCNA, , NBN, KDM1A
44	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	INF	NCOA3, , KDM1A, JUP, IL4, IL6
45	protein autophosphorylation	GO:046777	INF	, MTOR, ATM, INSR, FGFR1, FGFR3
46	positive regulation of gene expression	GO:010628	INF	NCOA3, , VEGFA, CD44, MET, MAPK8
47	positive regulation of transcription, DNA-dependent	GO:045893	INF	PIM2, NCOA1, NCOA3, RB1, MYC, BMP4
48	activation of MAPK activity	GO:000187	INF	, INSR, MET, MAP2K2, MAPK3, MAPK14
49	positive regulation of MAPK cascade	GO:043410	INF	, INS, INSR, FGFR1, FGFR3, IL6
50	signal transduction	GO:007165	INF	, KITLG, RARA, RARB, UTS2R, YWHAZ

Molecular functions related to rhabdomyosarcoma according to GeneDecks:

(show all 20)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	INF	PDGFRA, NOG, SMAD4, TERT, ERBB3, CARM1
2	protein binding	GO:005515	INF	EPHB1, PROM1, PSMC4, PSMA2, OS9, STAT5B
3	protein kinase binding	GO:019901	INF	, CCND1, HSPB1, TP53, TP73, PTPRC
4	protein serine/threonine kinase activity	GO:004674	INF	AKT1, PLK1, PDPK1, , TTN, DCLK1
5	identical protein binding	GO:042802	11.0	TP73, TP53, ERBB2, ESR1, AKT1, TNF
6	transcription coactivator activity	GO:003713	10.9	CARM1, ESR2, CTNNB1, SMARCA4, SMARCB1, COPS5
7	chromatin binding	GO:003682	10.8	DDX1, CTNNB1, SMAD4, SMARCA4, SKI, TOP1
8	insulin receptor binding	GO:005158	10.6	TLN1, PDPK1, PTPN11, IGF1, IGF2, IGF1R
9	receptor binding	GO:005102	10.5	TNFSF14, CRAT, PDGFRB, EDN3, CXADR, CXCL12
10	enzyme binding	GO:019899	10.3	CTNNB1, PLAUR, EGFR, TTN, THRB, TGFB1
11	cyclin-dependent protein kinase inhibitor activity	GO:004861	10.3	CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN1A, KAT2B
12	androgen receptor binding	GO:050681	10.2	SMARCA4, CTNNB1, CCNE1, FHL2, KDM1A, RB1
13	protein heterodimerization activity	GO:046982	10.2	ENO2, MCL1, APOB, IL12A, MET, ERBB3
14	transcription regulatory region DNA binding	GO:044212	10.2	CTNNB1, SMAD4, WT1, TFAP2A, TCF3, STAT3
15	insulin-like growth factor receptor binding	GO:005159	10.0	IGF1, IGF2, INSR, INS, IRS1, YWHAG
16	transcription factor binding	GO:008134	9.8	HMGA2, TP53, TP73, TPT1, SUFU, CTNNB1
17	growth factor activity	GO:008083	9.6	IGF2, IGF1, CTGF, NOV, TGFB1, CXCL12
18	cytokine activity	GO:005125	9.2	IL6, TNF, TNFSF10, TNFSF13B, TNFSF14, SPP1
19	protein tyrosine kinase activity	GO:004713	INF	IGF1R, ERBB3, ERBB2, PDGFRB, EGFR, TTN
20	ATP binding	GO:005524	INF	MYH7, , ABCG2, ABCC1, ABCB1, EGFR