MCID: RHM027
MIFTS: 52

Rheumatic Disease malady

Cardiovascular category

Summaries for Rheumatic Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and... more...

MalaCards: Rheumatic Disease, also known as rheumatic diseases, is related to arthritis and systemic lupus erythematosus. An important gene associated with Rheumatic Disease is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Osteoclast differentiation and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Rheumatic Disease

Sources:
10DISEASES, 45Novoseek, 25ICD10
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Related Diseases for Rheumatic Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.9COMP, CAST, TNFSF11, TNFRSF11B, MEFV, FLG
2systemic lupus erythematosus30.7FCGR2A
3hepatitis c30.5IL1R1, RNPC3
4vasculitis30.5APOH, PPBP, MEFV, TRIM21, TPMT
5osteoarthritis30.3COMP, CAST, TNFSF11, TNFRSF11B, PPBP, IL1R1
6hepatitis b30.3RNPC3, POLR3K
7atherosclerosis30.1COMP, TNFRSF11B, APOH, PPBP, IL1R1, HMGB1
8psoriatic arthritis30.1TNFRSF11B, TNFSF11, COMP
9vascular disease30.1PPBP, APOH, TNFRSF11B, TNFSF11
10autoimmune hepatitis30.1HMGB1, HMGB2, TPMT
11systemic scleroderma29.9COMP, CAST, LSM2, APOH, PPBP, POLR3K
12sjogren's syndrome29.9CAST, CALR, APOH, TRIM21, POLR3K, RNPC3
13synovitis29.9HMGB1, IL1R1, TNFRSF11B, TNFSF11, COMP
14nephritis29.9FCGR2A, IL1R1, RNPC3, APOH
15mixed connective tissue disease29.9LSM2, APOH, RNPC3
16lupus nephritis29.9FCGR2A, APOH
17cystic fibrosis29.9IL1R1, TNFRSF11B
18rubella29.9RNPC3, CALR
19hepatitis d10.5
20tuberculosis10.4
21hepatitis a10.4
22amyloidosis10.4
23progressive multifocal leukoencephalopathy10.3
24aortic disease10.3
25chronic pain10.3
26fibromyalgia10.3
27rheumatic pulmonary valve disease10.2
28hepatitis c virus10.2
29aortic valve disease10.2
30klinefelter's syndrome10.2
31rheumatic tricuspid valve disease10.2
32osteoporosis10.2
33amyloidosis, secondary10.2
34hepatitis b virus infection10.2
35coronary artery disease,10.1
36bronchiectasis10.1
37raynaud disease10.1
38septic arthritis10.1
39al amyloidosis10.1
40rheumatoid vasculitis10.1
41autonomic dysfunction10.1
42amyloidosis, renal10.1
43lip disease10.1
44rheumatoid arthritis10.0COMP, CAST, CALR, TNFSF11, TNFRSF11B, APOH
45hypersensitivity reaction type ii disease10.0TRIM21, POLR3K, RNPC3, IL1R1, HMGB1, FCGR2A
46melanoma10.0CALR, TNFSF11, TNFRSF11B, PPBP, MEFV, HMGB1
47thrombocytopenia10.0APOH, PPBP, IL11, IL1R1, FCGR2A, TPMT
48leukemia10.0PPBP, POLR3K, IL11, IL1R1, HMGB1, TPMT
49ulcerative colitis10.0TPMT, HMGB2, HMGB1, IL1R1, IL11, TNFSF11
50primary hyperoxaluria10.0TNFSF11, TNFRSF11B, PPBP, MEFV, RNPC3, FCGR2A

Graphical network of the top 20 diseases related to Rheumatic Disease:



Diseases related to rheumatic disease

Clinical Features for Rheumatic Disease

Drugs & Therapeutics for Rheumatic Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rheumatic Disease

Drug clinical trials:

Search ClinicalTrials for Rheumatic Disease

Search NIH Clinical Center for Rheumatic Disease

Search CenterWatch for Rheumatic Disease

Genetic Tests for Rheumatic Disease

Anatomical Context for Rheumatic Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Rheumatic Disease:

33
Bone marrow, Whole blood, Brain, Heart, Small intestine, Kidney, Liver, Thyroid, Breast, Skin, Monocytes, T cells, B cells, Endothelial, Fetal brain, Cardiac myocytes, Fetal liver, Fetal thyroid, Pituitary

Animal Models for Rheumatic Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Rheumatic Disease

Sources:
51PubMed
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Articles related to Rheumatic Disease:

(show top 50)    (show all 1093)
idTitleAuthorsYear
1
Accelerated junctional rhythm in children with acute rheumatic fever: is it specific to the disease? (23694767)
2013
2
Rheumatic fever & rheumatic heart disease: the last 50 years. (23703332)
2013
3
Rheumatic disease in wartime: the American Revolution--1775. (23519184)
2013
4
Duloxetine and pregabalin for pain management in multiple rheumatic diseases associated with fibromyalgia. (23126475)
2013
5
Addison's disease masked by long-term exogenous steroid treatment for presumed polymyalgia rheumatica. (22372233)
2012
6
A proposal for management of rheumatic disease patients with hepatitisA B virus infection receiving immunosuppressive therapy. (23242627)
2012
7
Adhesion molecule expression and ventricular remodeling in chronic rheumatic heart disease: a cause or effect in the disease progression--a pilot study. (22001052)
2012
8
Serum COMP-C3b complexes in rheumatic diseases and relation to anti-TNF-I+ treatment. (22264230)
2012
9
Pediatric rheumatic disease: Treating lupus nephritis in children--is there a gold standard? (22370458)
2012
10
Critical care of the pediatric patient with rheumatic disease. (21467937)
2011
11
Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. (19282307)
2010
12
Interferon therapy in rheumatic diseases: state-of-the-art 2010. (20061957)
2010
13
Plasma urotensin II as a marker for severity of rheumatic valve disease. (19398874)
2009
14
Prevention of rheumatic fever and diagnosis and treatment of acute Streptococcal pharyngitis: a scientific statement from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee of the Council on Cardiovascular Disease in the Young, the Interdisciplinary Council on Functional Genomics and Translational Biology, and the Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. (19246689)
2009
15
Acute rheumatic fever and rheumatic heart disease in indigenous populations. (19962028)
2009
16
Relationship between atrial fibroblast proliferation/fibrosis and atrial fibrillation in patients with rheumatic heart disease]. (20128380)
2009
17
Jak inhibitor ; possibility and mechanism as a new disease modifying anti-rheumatic drug. (19404006)
2009
18
Surgical repair of rheumatic mitral valve disease with Gregori-Braile's ring. (18820797)
2008
19
The role of drug and disease registries in rheumatic disease epidemiology. (18349740)
2008
20
Overexpression of transforming growth factor-beta 1 in the valvular fibrosis of chronic rheumatic heart disease. (18303197)
2008
21
Human leukocyte antigen (HLA) class II association with rheumatic heart disease in Pakistan. (17578052)
2007
22
Imatinib mesylate as a novel therapeutic drug for systemic rheumatic diseases]. (17603257)
2007
23
Pulmonary alveolar microlithiasis in a patient with rheumatic valvular heart disease. (17700203)
2007
24
What is the role for interleukin-1 receptor antagonist in rheumatic disease? (17369070)
2007
25
Rheumatic fever and rheumatic heart disease: genetics and pathogenesis. (17635797)
2007
26
Translating outcomes measurement in experimental therapeutics of systemic rheumatic disease to patient care. (16504818)
2006
27
Factorial validity and norm data comparison of the Short Form 12 in patients with inflammatory-rheumatic disease. (16179999)
2006
28
Autoimmunity to protective molecules: is it the perpetuum mobile (vicious cycle) of autoimmune rheumatic diseases? (16951703)
2006
29
Mimicry in recognition of cardiac myosin peptides by heart-intralesional T cell clones from rheumatic heart disease. (16622036)
2006
30
Value of contrast-enhanced ultrasound in rheumatic disease. (18637239)
2005
31
Prevalence of rheumatic disease in HIV infected Thai patients. (16518973)
2005
32
Effectiveness of the maze procedure using cooled-tip radiofrequency ablation in patients with permanent atrial fibrillation and rheumatic mitral valve disease. (16159816)
2005
33
Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. (16084221)
2005
34
Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum. (15539410)
2005
35
Antiphospholipid antibodies in pediatric and adult patients with rheumatic disease are associated with parvovirus B19 infection. (12847688)
2003
36
Minimal difference in pain associated with change in quality of life in children with rheumatic disease. (12382298)
2002
37
The immune tolerance network and rheumatic disease: immune tolerance comes to the clinic. (11508422)
2001
38
Neopterin: new immunological marker of autoimmune rheumatic disease]. (11019525)
2000
39
Polymyalgia rheumatica--an underdiagnosed disease. (11379486)
2000
40
The pain puzzle: a visual and conceptual metaphor for understanding and treating pain in pediatric rheumatic disease. (10782853)
2000
41
Collagen in the treatment of rheumatic diseases--oral tolerance]. (10649854)
1999
42
Relationship Between Echocardiographic Determinants of Left Atrial Spontaneous Echo Contrast and Thrombus Formation in Patients with Rheumatic Mitral Valve Disease. (11175158)
1999
43
Prevention of infectious complications in rheumatic disease patients: immunization, Pneumocystis carinii prophylaxis, and screening for latent infections. (10328575)
1999
44
Why do women have rheumatic disease? (9759123)
1998
45
Tumour necrosis factor alpha gene polymorphisms and rheumatic diseases. (9783754)
1998
46
Epidemiology and prevention of rheumatic fever and current issues in the prevention of rheumatic heart disease. (16379844)
1998
47
Is atrial fibrillation resulting from rheumatic mitral valve disease a proper indication for the maze procedure? (9647059)
1998
48
Malignancy and Rheumatic Disease. (10763023)
1997
49
Psychotherapy in rheumatoid arthritis--a parallel-process study of psychic state and course of rheumatic disease. (8868148)
1996
50
Adenohypophyseal and sex hormones in pediatric rheumatic diseases. (8496873)
1993

Genetic Variations for Rheumatic Disease

Expression for genes affiliated with Rheumatic Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rheumatic Disease

Search GEO for disease gene expression data for Rheumatic Disease.

Pathways for genes affiliated with Rheumatic Disease

Sources:
30KEGG, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Rheumatic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7FCGR2A, IL1R1, TNFRSF11B, TNFSF11
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.6CALR, TNFSF11, TNFRSF11B
310.6TNFRSF11B, TNFSF11
410.6TNFRSF11B, TNFSF11

Compounds for genes affiliated with Rheumatic Disease

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Rheumatic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1calcium45 50 11 2414.6APOH, TNFRSF11B, TNFSF11, CALR, CAST, COMP
2atp45 2912.5CAST, CALR, LSM2, TNFSF11, TNFRSF11B, APOH
3tyrosine4511.4PPBP, TNFRSF11B, TNFSF11, CALR, MEFV, FLG
4steroid4511.4TNFRSF11B, TNFSF11, CALR, COMP, APOH, FLG
5oligonucleotide4511.4POLR3K, TRIM21, CALR, COMP, RNPC3, IL11
6serine4511.4CAST, LSM2, TNFSF11, TNFRSF11B, FLG, POLR3K
7cysteine4511.4COMP, CAST, CALR, TNFSF11, TNFRSF11B, PPBP
8lipid4511.4COMP, CALR, TNFSF11, TNFRSF11B, APOH, PPBP
9creatinine4511.3COMP, CAST, TNFSF11, TNFRSF11B, APOH, PPBP
10heparin45 29 11 2414.3CALR, TNFSF11, TNFRSF11B, APOH, PPBP, IL11
11nitric oxide45 11 2413.3CALR, TNFSF11, TNFRSF11B, APOH, PPBP, FLG
12glucose4511.3COMP, CAST, CALR, TNFRSF11B, APOH, PPBP
13etanercept45 50 1113.3FCGR2A, COMP, TNFSF11, TNFRSF11B, APOH, IL11
14infliximab45 50 1113.3COMP, TNFSF11, TNFRSF11B, APOH, FLG, IL11
15zinc45 2412.2CALR, LSM2, TNFSF11, APOH, TRIM21, POLR3K
16fibrinogen4511.2TNFRSF11B, APOH, PPBP, FLG, IL11, IL1R1
17retinoic acid45 2412.2COMP, CAST, CALR, TNFRSF11B, FLG, IL11
18cyclosporin a45 29 6013.2TNFSF11, TNFRSF11B, RNPC3, IL11, IL1R1, HMGB1
19prednisolone45 29 1113.2COMP, TNFRSF11B, APOH, IL1R1, FCGR2A, TPMT
20methotrexate45 50 1113.2COMP, TNFSF11, TNFRSF11B, APOH, IL1R1, TPMT
21vitamin d4511.1COMP, CALR, TNFSF11, TNFRSF11B, IL11, IL1R1
22vegf4511.1CAST, TNFSF11, TNFRSF11B, APOH, PPBP, IL11
23arginine4511.1CALR, LSM2, APOH, FLG, RNPC3, IL1R1
24arachidonic acid45 29 11 2414.1TNFSF11, TNFRSF11B, PPBP, IL11, IL1R1, FCGR2A
25azathioprine45 50 2 1114.1TNFSF11, TNFRSF11B, APOH, IL11, TPMT
26phosphatidylinositol4511.1TNFSF11, TNFRSF11B, APOH, PPBP, IL11, IL1R1
27iron45 2412.1CALR, TNFRSF11B, APOH, RNPC3, IL11, IL1R1
28lactate4511.1COMP, CALR, APOH, PPBP, IL1R1, HMGB1
29agarose4511.1COMP, CAST, APOH, PPBP, POLR3K
30endotoxin4511.1APOH, MEFV, IL11, IL1R1, HMGB1
31deoxypyridinoline4511.1COMP, TNFSF11, TNFRSF11B, IL11
32dexamethasone45 50 29 1114.1CALR, TNFSF11, TNFRSF11B, PPBP, IL1R1
33leucine4511.0CALR, PPBP, MEFV, TRIM21, RNPC3, IL1R1
34oxygen45 2412.0CALR, TNFSF11, IL11, HMGB1
35p0034511.0PPBP, APOH, COMP
36histidine4510.9CALR, FLG, POLR3K, RNPC3, FCGR2A
37rantes4510.9IL1R1, IL11, PPBP
38gp 1304510.9TNFSF11, TNFRSF11B, IL11, IL1R1
39latex4510.9FLG, PPBP, APOH, TNFSF11
40adalimumab45 50 1112.9FCGR2A, IL1R1, COMP
41histamine45 29 2412.9TPMT, FCGR2A, IL11, PPBP, CALR
42silicone4510.8IL1R1, RNPC3, PPBP
43titanium4510.8TNFSF11, TNFRSF11B, IL11
44hcc-14510.8TNFRSF11B, TNFSF11
45urea45 11 2412.7CALR, TNFSF11, TNFRSF11B, FLG
46estrogen4510.7APOH, HMGB2
47tgf beta14510.7IL11, PPBP, TNFRSF11B, COMP
48magnesium45 11 2412.6CALR, TNFRSF11B, POLR3K, RNPC3, IL1R1, HMGB1
49leflunomide50 45 1112.6COMP, TNFSF11, IL1R1
50alendronate45 50 1112.3TNFSF11, TNFRSF11B, IL11

GO Terms for genes affiliated with Rheumatic Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8CALR, TNFSF11, TNFRSF11B, PPBP, IL11, IL1R1
2extracellular spaceGO:00561510.6HMGB2, COMP, CALR, TNFSF11, TNFRSF11B, APOH

Biological processes related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.7FCGR2A, HMGB1, POLR3K, TRIM21, MEFV
2base-excision repair, DNA ligationGO:00628810.6HMGB2, HMGB1
3DNA ligation involved in DNA repairGO:05110310.6HMGB2, HMGB1
4V(D)J recombinationGO:03315110.5HMGB2, HMGB1
5DNA topological changeGO:00626510.3HMGB1, HMGB2

Molecular functions related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.6HMGB2, HMGB1
2cytokine activityGO:00512510.3HMGB1, IL11, TNFRSF11B, TNFSF11

Products for genes affiliated with Rheumatic Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet