MCID: RHM027
MIFTS: 41

Rheumatic Disease malady

Cardiovascular diseases category
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Summaries for Rheumatic Disease

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Sources:
65Wikipedia, 33MalaCards
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Wikipedia:65 Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and... more...

MalaCards: Rheumatic Disease, also known as rheumatic diseases, is related to lupus erythematosus and rheumatoid arthritis. An important gene associated with Rheumatic Disease is KIR3DS1 (killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1). The compounds cardiolipin and poly u have been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and bone.

Aliases & Classifications for Rheumatic Disease

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10DISEASES, 45Novoseek, 25ICD10
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Related Diseases for Rheumatic Disease

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17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 110)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.7TRIM21
2rheumatoid arthritis30.5TNFRSF13C, PTX3, RNPC3, KLRC2, TRIM21, TRG
3systemic lupus erythematosus30.5TNFRSF13C, POLR3K, RNPC3, KLRC2, LSM2, TRIM21
4connective tissue disease30.4TRIM21
5vasculitis30.4TRIM21, PTX3
6mixed connective tissue disease29.9RNPC3, LSM2
7sjogren's syndrome29.8TRIM21, RNPC3, POLR3K
8arthritis10.6
9hepatitis10.4
10tuberculosis10.4
11hepatitis b10.3
12amyloidosis10.3
13progressive multifocal leukoencephalopathy10.3
14fibromyalgia10.2
15osteoarthritis10.2
16influenza10.2
17macrophage activation syndrome10.2
18hepatitis b virus infection10.2
19endotheliitis10.2
20klinefelter's syndrome10.1
21hepatitis c10.1
22dermatomyositis10.1
23osteoporosis10.1
24hepatitis c virus10.1
25spinal muscular atrophy10.0LSM2, RNPC3
26bronchiectasis10.0
27septic arthritis10.0
28psoriatic arthritis10.0
29rheumatic pulmonary valve disease10.0
30atherosclerosis10.0
31hypertension10.0
32panniculitis10.0
33retinitis10.0
34scleroderma10.0
35autonomic dysfunction10.0
36systemic scleroderma10.0LSM2, RNPC3, POLR3K
37myositis10.0TRIM21, RNPC3
38hypersensitivity reaction type ii disease9.9TNFRSF13C, PTX3, POLR3K, RNPC3, LSM2, TRIM21
39burns9.9
40coronary artery disease9.9
41rubella9.9
42autoimmune thyroiditis9.9
43mononeuritis multiplex9.9
44cystic fibrosis9.9
45pseudogout9.9
46obstructive sleep apnea9.9
47thromboangiitis obliterans9.9
48gastric ulcer9.9
49agoraphobia9.9
50reactive arthritis9.9

Graphical network of the top 20 diseases related to Rheumatic Disease:



Diseases related to rheumatic disease

Symptoms for Rheumatic Disease

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Drugs & Therapeutics for Rheumatic Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rheumatic Disease

Search NIH Clinical Center for Rheumatic Disease

Genetic Tests for Rheumatic Disease

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Anatomical Context for Rheumatic Disease

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33MalaCards
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MalaCards organs/tissues related to Rheumatic Disease:

33
Testes, T cells, Bone, Heart, Breast, Skin, B cells, Endothelial, Eye, Liver, Bone marrow, Thyroid, Brain, Monocytes

Animal Models for Rheumatic Disease or affiliated genes

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Publications for Rheumatic Disease

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52PubMed
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Articles related to Rheumatic Disease:

(show top 50)    (show all 721)
idTitleAuthorsYear
1
Changing incidence of orthopedic surgery in rheumatic disease: contributing factors. (23955065)
2013
2
Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. (23280167)
2013
3
Bone research in 2012: the ups and downs of bone in health and rheumatic disease. (23296393)
2013
4
Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment. (23972423)
2013
5
Perioperative infection in the patient with rheumatic disease. (24150870)
2013
6
Impact of aspirin use in the incidence of thromboembolic events after bioprosthesis replacement in patients with rheumatic disease. (24343684)
2013
7
Pediatric rheumatic disease in the intensive care unit: lessons learned from 15 years of experience in a tertiary care pediatric hospital. (22561277)
2012
8
Paediatric rheumatic disease: Classification warfare. (22986458)
2012
9
Use of biological disease-modifying anti-rheumatic drugs in patients with concurrent rheumatic disease and hepatitis B. (21790927)
2012
10
Regenerative medicine in rheumatic disease-progress in tissue engineering. (22782007)
2012
11
Italian multicentre study for application of a diagnostic algorithm in autoantibody testing for autoimmune rheumatic disease: conclusive results. (21741498)
2011
12
Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases. (22046967)
2011
13
Value of serum and synovial fluid activin A and inhibin A in some rheumatic diseases. (20704626)
2010
14
Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. (19282307)
2010
15
Ultrasound of enthesopathy in rheumatic diseases. (19002749)
2009
16
Use of the T-SPOT.TB assay to detect latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy. (19228655)
2009
17
SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended? (19895718)
2009
18
Anti-cytokine antibodies for rheumatic diseases. (19876788)
2009
19
Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease. (18285764)
2008
20
A new approach to mitral valve repair for rheumatic disease: preliminary study. (19137791)
2008
21
Commentary - ordering lab tests for suspected rheumatic disease. (19014701)
2008
22
A case of recurrent rash and leg numbness mimicking systemic rheumatic disease: the occurrence of leprosy in a nonendemic area. (17551381)
2007
23
Prevention of rheumatic disease. (17787047)
2007
24
Recommendations from the Community Oriented Program for Control of Rheumatic Disease for data collection for the measurement and monitoring of health in developing countries. (17364136)
2007
25
The clinical application of etanercept in Chinese patients with rheumatic diseases. (16906369)
2006
26
Serial radionuclide angiographic assessment of left ventricular ejection fraction and regional wall motion after mitral valve replacement in patients with rheumatic disease. (17161076)
2006
27
Value of contrast-enhanced ultrasound in rheumatic disease. (18637239)
2005
28
Rheumatic disease in an Australian Aboriginal community in North Queensland, Australia. A WHO-ILAR COPCORD survey. (15124258)
2004
29
Aspects of nailfold capillaroscopy in children and young people with rheumatic disease. (15529611)
2004
30
Laboratory indicators of endothelial involvement in rheumatic diseases associated with vasculitis in children]. (14635427)
2003
31
Assessing the efficacy and safety of rheumatic disease treatments: obstacles and proposed solutions. (12847670)
2003
32
Treatment of peptic ulcer related to rheumatic diseases]. (12187755)
2002
33
Cutaneous palisaded allergic granuloma associated with rheumatic disease. (12031032)
2002
34
Sex ratio and rheumatic disease. (11791419)
2001
35
Neopterin: new immunological marker of autoimmune rheumatic disease]. (11019525)
2000
36
Assessment of quality of life in children with rheumatic disease. (10405925)
1999
37
Antimalarial ocular toxicity in rheumatic disease. (19078282)
1998
38
Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease. (9704650)
1998
39
Drug treatment of rheumatic diseases in the 1990s. Achievements and future developments. (9074838)
1997
40
Biological markers in inflammatory rheumatic diseases. (8747080)
1995
41
Antibodies to the extractable nuclear antigens (ENA) in Pakistani patients with systemic rheumatic disease. (7731078)
1995
42
Patient education in rheumatic disease. (7727240)
1995
43
Silicone breast implants and rheumatic disease. Clinical, immunologic, and epidemiologic studies. (8129771)
1994
44
Expression of a developmentally regulated epitope on fibronectins from the synovial fluid of patients with rheumatic disease. (7530772)
1994
45
Cutaneous infection with rapidly growing mycobacteria in patients with systemic rheumatic disease. (7842536)
1994
46
Calreticulin synthetic peptide analogues: anti-peptide antibodies in autoimmune rheumatic diseases. (7680295)
1993
47
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. (1347295)
1992
48
Rheumatic disease as initial symptom of HIV infection]. (1552970)
1992
49
Trimer and tetramer complexes containing C1 esterase inhibitor, C1r and C1s, in serum and synovial fluid of patients with rheumatic disease. (2338498)
1990
50
Epitope patterns of anti-RNP antibodies in rheumatic diseases. Evidence for an antigen-driven autoimmune response. (1694665)
1990

Variations for Rheumatic Disease

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Expression for genes affiliated with Rheumatic Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Disease

Search GEO for disease gene expression data for Rheumatic Disease.

Pathways for genes affiliated with Rheumatic Disease

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Compounds for genes affiliated with Rheumatic Disease

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45Novoseek, 11DrugBank, 24HMDB
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Compounds related to Rheumatic Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cardiolipin45 1110.4TRIM21, RNPC3
2poly u459.3RNPC3, POLR3K
3rrna459.1RNPC3, POLR3K
4trna458.9RNPC3, POLR3K
5actinomycin d458.9LSM2, POLR3K, PTX3
6zinc45 249.3POLR3K, RNPC3, LSM2, TRIM21

GO Terms for genes affiliated with Rheumatic Disease

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16Gene Ontology
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Biological processes related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of type I interferon productionGO:0324819.7TRIM21, POLR3K
2innate immune responseGO:0450878.9TRIM21, KLRC2, KIR3DS1, POLR3K

Products for genes affiliated with Rheumatic Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet