MCID: RHM027
MIFTS: 50

Rheumatic Disease malady

Cardiovascular diseases category
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Summaries for Rheumatic Disease

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Wikipedia:65 Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and... more...

MalaCards based summary: Rheumatic Disease, also known as rheumatic diseases, is related to lupus erythematosus and connective tissue disease. An important gene associated with Rheumatic Disease is KIR3DS1 (killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1). The drugs cyclophosphamide and hydrocortisone and the compounds cardiolipin and poly u have been mentioned in the context of this disorder. Affiliated tissues include testes, bone and t cells.

Aliases & Classifications for Rheumatic Disease

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Sources:
10DISEASES, 44Novoseek, 62UMLS, 25ICD10
See all sources

Rheumatic Disease, Aliases & Descriptions:

Name: Rheumatic Disease 10
Rheumatic Diseases 44 62
 
Disease, Rheumatic 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

ICD1025 I06.9, I09.9

Related Diseases for Rheumatic Disease

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Diseases related to Rheumatic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 111)
idRelated DiseaseScoreTop Affiliating Genes
1lupus erythematosus30.8TRIM21
2connective tissue disease30.7TRIM21
3vasculitis30.6TRIM21, PTX3
4mixed connective tissue disease30.1RNPC3, LSM2
5rheumatoid arthritis30.0TNFRSF13C, PTX3, RNPC3, KLRC2, TRIM21, TRG
6systemic lupus erythematosus30.0TNFRSF13C, POLR3K, RNPC3, KLRC2, LSM2, TRIM21
7sjogren's syndrome29.9TRIM21, RNPC3, POLR3K
8arthritis10.6
9hepatitis10.4
10tuberculosis10.4
11hepatitis b10.3
12amyloidosis10.3
13progressive multifocal leukoencephalopathy10.3
14macrophage activation syndrome10.2
15fibromyalgia10.2
16osteoarthritis10.2
17dermatomyositis10.2
18influenza10.2
19hepatitis b virus infection10.2
20endotheliitis10.2
21spinal muscular atrophy10.2LSM2, RNPC3
22osteoporosis10.1
23klinefelter's syndrome10.1
24hepatitis c10.1
25hepatitis c virus10.1
26systemic scleroderma10.1LSM2, RNPC3, POLR3K
27myositis10.0TRIM21, RNPC3
28atherosclerosis10.0
29hypertension10.0
30neutropenia10.0
31septic arthritis10.0
32rheumatic pulmonary valve disease10.0
33bronchiectasis10.0
34psoriatic arthritis10.0
35mitral valve disease10.0
36panniculitis10.0
37retinitis10.0
38scleroderma10.0
39tricuspid valve disease10.0
40autonomic dysfunction10.0
41acute myocardial infarction9.9
42burns9.9
43cystic fibrosis9.9
44hematopoietic stem cell transplantation9.9
45myelodysplastic syndromes9.9
46myocardial infarction9.9
47non-hodgkin lymphoma9.9
48obesity9.9
49pulmonary hypertension9.9
50thromboangiitis obliterans9.9

Graphical network of the top 20 diseases related to Rheumatic Disease:



Diseases related to rheumatic disease

Symptoms for Rheumatic Disease

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Genetic Tests for Rheumatic Disease

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Anatomical Context for Rheumatic Disease

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MalaCards organs/tissues related to Rheumatic Disease:

32
Testes, Bone, T cells, Heart, Breast, Skin, B cells, Endothelial, Eye, Liver, Bone marrow, Brain, Thyroid, Monocytes, Neutrophil

Animal Models for Rheumatic Disease or affiliated genes

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Publications for Rheumatic Disease

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Articles related to Rheumatic Disease:

(show top 50)    (show all 742)
idTitleAuthorsYear
1
Comparison of cancer incidence among patients with rheumatic disease: a retrospective cohort study. (25163486)
2014
2
Changing incidence of orthopedic surgery in rheumatic disease: contributing factors. (23955065)
2013
3
Low prevalence of anti-DFS70/LEDGF antibodies in patients with dermatomyositis and other systemic autoimmune rheumatic diseases. (23280167)
2013
4
Bone research in 2012: the ups and downs of bone in health and rheumatic disease. (23296393)
2013
5
Systemic lupus erythematosus and other autoimmune rheumatic diseases: challenges to treatment. (23972423)
2013
6
Perioperative infection in the patient with rheumatic disease. (24150870)
2013
7
Impact of aspirin use in the incidence of thromboembolic events after bioprosthesis replacement in patients with rheumatic disease. (24343684)
2013
8
Pediatric rheumatic disease in the intensive care unit: lessons learned from 15 years of experience in a tertiary care pediatric hospital. (22561277)
2012
9
Paediatric rheumatic disease: Classification warfare. (22986458)
2012
10
Use of biological disease-modifying anti-rheumatic drugs in patients with concurrent rheumatic disease and hepatitis B. (21790927)
2012
11
Regenerative medicine in rheumatic disease-progress in tissue engineering. (22782007)
2012
12
Italian multicentre study for application of a diagnostic algorithm in autoantibody testing for autoimmune rheumatic disease: conclusive results. (21741498)
2011
13
Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases. (22046967)
2011
14
Value of serum and synovial fluid activin A and inhibin A in some rheumatic diseases. (20704626)
2010
15
Bcl-2 antagonist killer 1 (BAK1) polymorphisms influence the risk of developing autoimmune rheumatic diseases in women. (19282307)
2010
16
Ultrasound of enthesopathy in rheumatic diseases. (19002749)
2009
17
Use of the T-SPOT.TB assay to detect latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy. (19228655)
2009
18
SAPHO syndrome: is a range of pathogen-associated rheumatic diseases extended? (19895718)
2009
19
Anti-cytokine antibodies for rheumatic diseases. (19876788)
2009
20
Technology Insight: hematopoietic stem cell transplantation for systemic rheumatic disease. (18285764)
2008
21
A new approach to mitral valve repair for rheumatic disease: preliminary study. (19137791)
2008
22
Commentary - ordering lab tests for suspected rheumatic disease. (19014701)
2008
23
A case of recurrent rash and leg numbness mimicking systemic rheumatic disease: the occurrence of leprosy in a nonendemic area. (17551381)
2007
24
Prevention of rheumatic disease. (17787047)
2007
25
The clinical application of etanercept in Chinese patients with rheumatic diseases. (16906369)
2006
26
Serial radionuclide angiographic assessment of left ventricular ejection fraction and regional wall motion after mitral valve replacement in patients with rheumatic disease. (17161076)
2006
27
Value of contrast-enhanced ultrasound in rheumatic disease. (18637239)
2005
28
Rheumatic disease in an Australian Aboriginal community in North Queensland, Australia. A WHO-ILAR COPCORD survey. (15124258)
2004
29
Aspects of nailfold capillaroscopy in children and young people with rheumatic disease. (15529611)
2004
30
Rheumatic disease differentiation using immunoglobulin G sugar printing by high density electrophoresis. (14719191)
2003
31
Laboratory indicators of endothelial involvement in rheumatic diseases associated with vasculitis in children]. (14635427)
2003
32
Assessing the efficacy and safety of rheumatic disease treatments: obstacles and proposed solutions. (12847670)
2003
33
Treatment of peptic ulcer related to rheumatic diseases]. (12187755)
2002
34
Cutaneous palisaded allergic granuloma associated with rheumatic disease. (12031032)
2002
35
Sex ratio and rheumatic disease. (11791419)
2001
36
Neopterin: new immunological marker of autoimmune rheumatic disease]. (11019525)
2000
37
Assessment of quality of life in children with rheumatic disease. (10405925)
1999
38
Antimalarial ocular toxicity in rheumatic disease. (19078282)
1998
39
Cytogenetic abnormalities and therapy-related myelodysplastic syndromes in rheumatic disease. (9704650)
1998
40
Drug treatment of rheumatic diseases in the 1990s. Achievements and future developments. (9074838)
1997
41
Biological markers in inflammatory rheumatic diseases. (8747080)
1995
42
Antibodies to the extractable nuclear antigens (ENA) in Pakistani patients with systemic rheumatic disease. (7731078)
1995
43
Patient education in rheumatic disease. (7727240)
1995
44
Silicone breast implants and rheumatic disease. Clinical, immunologic, and epidemiologic studies. (8129771)
1994
45
Expression of a developmentally regulated epitope on fibronectins from the synovial fluid of patients with rheumatic disease. (7530772)
1994
46
Calreticulin synthetic peptide analogues: anti-peptide antibodies in autoimmune rheumatic diseases. (7680295)
1993
47
Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. (1347295)
1992
48
Rheumatic disease as initial symptom of HIV infection]. (1552970)
1992
49
Trimer and tetramer complexes containing C1 esterase inhibitor, C1r and C1s, in serum and synovial fluid of patients with rheumatic disease. (2338498)
1990
50
Epitope patterns of anti-RNP antibodies in rheumatic diseases. Evidence for an antigen-driven autoimmune response. (1694665)
1990

Variations for Rheumatic Disease

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Expression for genes affiliated with Rheumatic Disease

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Expression patterns in normal tissues for genes affiliated with Rheumatic Disease

Search GEO for disease gene expression data for Rheumatic Disease.

Pathways for genes affiliated with Rheumatic Disease

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Compounds for genes affiliated with Rheumatic Disease

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Sources:
44Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Rheumatic Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1cardiolipin44 1110.4TRIM21, RNPC3
2poly u449.3RNPC3, POLR3K
3rrna449.1RNPC3, POLR3K
4trna448.9RNPC3, POLR3K
5actinomycin d448.9LSM2, POLR3K, PTX3
6zinc44 249.3POLR3K, RNPC3, LSM2, TRIM21

GO Terms for genes affiliated with Rheumatic Disease

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Biological processes related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of type I interferon productionGO:0324819.7TRIM21, POLR3K
2innate immune responseGO:0450878.9TRIM21, KLRC2, KIR3DS1, POLR3K

Products for genes affiliated with Rheumatic Disease

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  • Antibodies
  • Proteins
  • Lysates

Sources for Rheumatic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet