MCID: RHM027
MIFTS: 40

Rheumatic Disease malady

Cardiovascular diseases category

Summaries for Rheumatic Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Rheumatism or rheumatic disorder is a non-specific term for medical problems affecting the joints and... more...

MalaCards: Rheumatic Disease, also known as rheumatic diseases, is related to arthritis and rheumatoid arthritis. An important gene associated with Rheumatic Disease is APOH (apolipoprotein H (beta-2-glycoprotein I)), and among its related pathways are Osteoclast differentiation and Transcription Role of VDR in regulation of genes involved in osteoporosis. The compounds calcium and atp have been mentioned in the context of this disorder. Affiliated tissues include heart, and related mouse phenotypes are mortality/aging and cellular.

Aliases & Classifications for Rheumatic Disease

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10DISEASES, 44Novoseek, 25ICD10
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Related Diseases for Rheumatic Disease

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17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 183)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8COMP, CAST, TNFSF11, TNFRSF11B, MEFV, FLG
2rheumatoid arthritis30.7COMP, CAST, CALR, TNFSF11, TNFRSF11B, APOH
3lupus erythematosus30.7CALR, APOH, TRIM21
4systemic lupus erythematosus30.7FCGR2A
5hepatitis b30.5RNPC3, POLR3K
6vasculitis30.4APOH, PPBP, MEFV, TRIM21, TPMT
7connective tissue disease30.3CAST, CALR, APOH, RNPC3
8osteoarthritis30.3COMP, CAST, TNFSF11, TNFRSF11B, PPBP, IL1R1
9hepatitis c30.3IL1R1, RNPC3
10autoimmune hepatitis30.2HMGB1, HMGB2, TPMT
11atherosclerosis30.1COMP, TNFRSF11B, APOH, PPBP, IL1R1, HMGB1
12psoriatic arthritis30.0TNFRSF11B, TNFSF11, COMP
13vascular disease30.0PPBP, APOH, TNFRSF11B, TNFSF11
14hypertension30.0PPBP
15systemic scleroderma29.8COMP, CAST, LSM2, APOH, PPBP, POLR3K
16sjogren's syndrome29.8CAST, CALR, APOH, TRIM21, POLR3K, RNPC3
17synovitis29.8HMGB1, IL1R1, TNFRSF11B, TNFSF11, COMP
18mixed connective tissue disease29.8LSM2, APOH, RNPC3
19neutropenia29.8TPMT, IL11
20cystic fibrosis29.8IL1R1, TNFRSF11B
21inflammatory bowel disease29.8TPMT
22rubella29.8RNPC3, CALR
23hepatitis10.5
24tuberculosis10.4
25mitral valve disease10.3
26amyloidosis10.3
27progressive multifocal leukoencephalopathy10.3
28aortic disease10.2
29breast disease10.2
30rheumatic disease of mitral valve10.2
31skin disease10.2
32rheumatic pulmonary valve disease10.2
33dermatomyositis10.2
34influenza10.2
35klinefelter's syndrome10.1
36rheumatic tricuspid valve disease10.1
37osteoporosis10.1
38cartilage disease10.1
39collagen disease10.1
40coronary artery disease10.0
41bronchiectasis10.0
42septic arthritis10.0
43hepatitis a10.0
44eye disease10.0
45liver disease10.0
46panniculitis10.0
47pulmonary valve disease10.0
48retinal disease10.0
49retinitis10.0
50scleroderma10.0

Graphical network of the top 20 diseases related to Rheumatic Disease:



Diseases related to rheumatic disease

Clinical Features for Rheumatic Disease

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Drugs & Therapeutics for Rheumatic Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rheumatic Disease

Drug clinical trials:

Search ClinicalTrials for Rheumatic Disease

Search NIH Clinical Center for Rheumatic Disease

Search CenterWatch for Rheumatic Disease

Genetic Tests for Rheumatic Disease

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Anatomical Context for Rheumatic Disease

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32MalaCards
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MalaCards organs/tissues related to Rheumatic Disease:

32
Heart

Animal Models for Rheumatic Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Rheumatic Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001076811.0TPMT, CAST, CALR, TNFSF11, TNFRSF11B, APOH
2MP:000538410.9HMGB1, IL1R1, TRIM21, FLG, MEFV, TNFRSF11B
3MP:000537610.8HMGB1, IL1R1, TRIM21, FLG, MEFV, APOH
4MP:000539710.6TPMT, TNFSF11, TNFRSF11B, MEFV, FLG, TRIM21

Publications for Rheumatic Disease

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Genetic Variations for Rheumatic Disease

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Expression for genes affiliated with Rheumatic Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Disease

Search GEO for disease gene expression data for Rheumatic Disease.

Pathways for genes affiliated with Rheumatic Disease

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29KEGG, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Rheumatic Disease according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.7FCGR2A, IL1R1, TNFRSF11B, TNFSF11
2
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.6CALR, TNFSF11, TNFRSF11B
310.6TNFRSF11B, TNFSF11
410.6TNFRSF11B, TNFSF11

Compounds for genes affiliated with Rheumatic Disease

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Rheumatic Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1calcium44 49 11 2414.6APOH, TNFRSF11B, TNFSF11, CALR, CAST, COMP
2atp44 2812.5CAST, CALR, LSM2, TNFSF11, TNFRSF11B, APOH
3tyrosine4411.4PPBP, TNFRSF11B, TNFSF11, CALR, MEFV, FLG
4steroid4411.4TNFRSF11B, TNFSF11, CALR, COMP, APOH, FLG
5oligonucleotide4411.4POLR3K, TRIM21, CALR, COMP, RNPC3, IL11
6serine4411.4CAST, LSM2, TNFSF11, TNFRSF11B, FLG, POLR3K
7cysteine4411.4COMP, CAST, CALR, TNFSF11, TNFRSF11B, PPBP
8lipid4411.4COMP, CALR, TNFSF11, TNFRSF11B, APOH, PPBP
9creatinine4411.3COMP, CAST, TNFSF11, TNFRSF11B, APOH, PPBP
10heparin44 28 11 2414.3CALR, TNFSF11, TNFRSF11B, APOH, PPBP, IL11
11nitric oxide44 11 2413.3CALR, TNFSF11, TNFRSF11B, APOH, PPBP, FLG
12glucose4411.3COMP, CAST, CALR, TNFRSF11B, APOH, PPBP
13etanercept44 49 1113.3FCGR2A, COMP, TNFSF11, TNFRSF11B, APOH, IL11
14infliximab44 49 1113.3COMP, TNFSF11, TNFRSF11B, APOH, FLG, IL11
15zinc44 2412.2CALR, LSM2, TNFSF11, APOH, TRIM21, POLR3K
16fibrinogen4411.2TNFRSF11B, APOH, PPBP, FLG, IL11, IL1R1
17retinoic acid44 2412.2COMP, CAST, CALR, TNFRSF11B, FLG, IL11
18cyclosporin a44 28 5913.2TNFSF11, TNFRSF11B, RNPC3, IL11, IL1R1, HMGB1
19prednisolone44 28 1113.2COMP, TNFRSF11B, APOH, IL1R1, FCGR2A, TPMT
20methotrexate44 49 1113.2COMP, TNFSF11, TNFRSF11B, APOH, IL1R1, TPMT
21vitamin d4411.1COMP, CALR, TNFSF11, TNFRSF11B, IL11, IL1R1
22vegf4411.1CAST, TNFSF11, TNFRSF11B, APOH, PPBP, IL11
23arginine4411.1CALR, LSM2, APOH, FLG, RNPC3, IL1R1
24arachidonic acid44 28 11 2414.1TNFSF11, TNFRSF11B, PPBP, IL11, IL1R1, FCGR2A
25azathioprine44 49 2 1114.1TNFSF11, TNFRSF11B, APOH, IL11, TPMT
26phosphatidylinositol4411.1TNFSF11, TNFRSF11B, APOH, PPBP, IL11, IL1R1
27iron44 2412.1CALR, TNFRSF11B, APOH, RNPC3, IL11, IL1R1
28lactate4411.1COMP, CALR, APOH, PPBP, IL1R1, HMGB1
29agarose4411.1COMP, CAST, APOH, PPBP, POLR3K
30endotoxin4411.1APOH, MEFV, IL11, IL1R1, HMGB1
31deoxypyridinoline4411.1COMP, TNFSF11, TNFRSF11B, IL11
32dexamethasone44 49 28 1114.1CALR, TNFSF11, TNFRSF11B, PPBP, IL1R1
33leucine4411.0CALR, PPBP, MEFV, TRIM21, RNPC3, IL1R1
34oxygen44 2412.0CALR, TNFSF11, IL11, HMGB1
35p0034411.0PPBP, APOH, COMP
36histidine4410.9CALR, FLG, POLR3K, RNPC3, FCGR2A
37rantes4410.9IL1R1, IL11, PPBP
38gp 1304410.9TNFSF11, TNFRSF11B, IL11, IL1R1
39latex4410.9FLG, PPBP, APOH, TNFSF11
40adalimumab44 49 1112.9FCGR2A, IL1R1, COMP
41histamine44 28 2412.9TPMT, FCGR2A, IL11, PPBP, CALR
42silicone4410.8IL1R1, RNPC3, PPBP
43titanium4410.8TNFSF11, TNFRSF11B, IL11
44hcc-14410.8TNFRSF11B, TNFSF11
45urea44 11 2412.7CALR, TNFSF11, TNFRSF11B, FLG
46estrogen4410.7APOH, HMGB2
47tgf beta14410.7IL11, PPBP, TNFRSF11B, COMP
48magnesium44 11 2412.6CALR, TNFRSF11B, POLR3K, RNPC3, IL1R1, HMGB1
49leflunomide49 44 1112.6COMP, TNFSF11, IL1R1
50alendronate44 49 1112.3TNFSF11, TNFRSF11B, IL11

GO Terms for genes affiliated with Rheumatic Disease

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16Gene Ontology
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Cellular components related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.8COMP, CALR, TNFSF11, TNFRSF11B, PPBP, IL11
2extracellular spaceGO:00561510.6COMP, CALR, TNFSF11, TNFRSF11B, APOH, PPBP

Biological processes related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1innate immune responseGO:04508710.7HMGB1, POLR3K, TRIM21, MEFV, FCGR2A
2base-excision repair, DNA ligationGO:00628810.6HMGB2, HMGB1
3DNA ligation involved in DNA repairGO:05110310.6HMGB1, HMGB2
4V(D)J recombinationGO:03315110.5HMGB2, HMGB1
5DNA topological changeGO:00626510.3HMGB2, HMGB1

Molecular functions related to Rheumatic Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RAGE receptor bindingGO:05078610.6HMGB2, HMGB1
2cytokine activityGO:00512510.3HMGB1, IL11, TNFRSF11B, TNFSF11

Products for genes affiliated with Rheumatic Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet