MCID: RHM001
MIFTS: 53

Rheumatic Fever malady

Categories: Rare diseases, Cardiovascular diseases, Bone diseases

Aliases & Classifications for Rheumatic Fever

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Rheumatic Fever:

Name: Rheumatic Fever 10 45 47 12 51 36 65
Acute Rheumatic Fever 10 45 47 51
 
Inflammatory Rheumatism 45
Rhf - Rheumatic Fever 10

Characteristics:

Orphanet epidemiological data:

51
rheumatic fever:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult

Classifications:



External Ids:

Disease Ontology10 DOID:1586
ICD1027 I00, I00-I02
ICD9CM29 390, 390-392.99
MeSH36 D012213
NCIt42 C34984
Orphanet51 3099
UMLS via Orphanet66 C0035436
ICD10 via Orphanet28 I00, I01.0, I01.1 I01.2, I01.8, I01.9, more
MESH via Orphanet37 D012213
UMLS65 C0035436, C0264743

Summaries for Rheumatic Fever

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NIH Rare Diseases:45 Rheumatic fever is an inflammatory condition that may develop after infection with group a streptococcus bacteria, such as strep throat or scarlet fever. it is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. it is not clear why some people who are infected with group a streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. treatment usually includes antibiotics and/or anti-inflammatory medications. last updated: 1/11/2015

MalaCards based summary: Rheumatic Fever, also known as acute rheumatic fever, is related to lateral sclerosis and scleritis, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, macules and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Rheumatic Fever is MBL2 (Mannose Binding Lectin 2), and among its related pathways are Inflammatory Response Pathway and Immune response_MIF-mediated glucocorticoid regulation. The drugs aspirin and choline salicylate have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related mouse phenotype immune system.

Wikipedia:68 Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve... more...

Related Diseases for Rheumatic Fever

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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 490)
idRelated DiseaseScoreTop Affiliating Genes
1lateral sclerosis30.4CD40LG, TLR2, TNF
2scleritis30.3CD40LG, MBL2
3membranous glomerulonephritis30.3CD40LG, TNF
4ileocolitis30.3TLR2, TNF
5basilar artery occlusion29.8IL2, TNF
6rheumatoid arthritis29.5CD40LG, HLA-DQA1, IL2, TLR2, TNF
7malaria29.0CD40LG, HP, IL2, TLR2, TNF
8systemic lupus erythematosus28.8CD40LG, FCN3, HLA-DQA1, IL2, MBL2, TNF
9rheumatic myocarditis12.0
10acute articular rheumatism11.4
11sydenham's chorea11.2
12chorea minor10.7
13hypophosphatasia10.5MBL2, TNF
14waardenburg syndrome type 410.5MBL2, TNF
15malignant sertoli-leydig cell tumor of ovary10.5MYOM2, TNF
16drug-induced mental disorder10.5HLA-DQA1, TNF
17hair defect with photosensitivity and mental retardation10.4TLR2, TNF
18protein r deficiency10.4MBL2, TLR2
19anti-hla hyperimmunization10.4TLR2, TNF
20tuberculous uveitis10.4TLR2, TNF
21streptococcal meningitis10.4MBL2, TNF
22noonan-like/multiple giant cell lesion syndrome10.4TLR2, TNF
23cryptosporidiosis10.4HLA-DQA1, TNF
24acrofrontofacionasal dysostosis10.4MASP2, MBL2
25neonatal adrenoleukodystrophy10.4MBL2, TLR2
26occipital lobe neoplasm10.4TLR2, TNF
27erdheim-chester disease10.4CD40LG, TNF
28sjogren's syndrome10.4CD40LG, TNF
29immunotactoid glomerulopathy10.4CD40LG, MBL2
30congenital nasal pyriform aperture stenosis with holoprosencephaly10.4MBL2, TNF
31rhinoscleroma10.4CD40LG, TNF
32duodenum cancer10.4HLA-DQA1, TNF
33aortic valve disease 210.4
34choreatic disease10.4
35rheumatic encephalitis10.4
36saint vitus dance10.4
37ureterocele10.4IL2, TNF
38breast cancer10.3
39refractory plasma cell neoplasm10.3CD40LG, TNF
40cauda equina syndrome10.3CD40LG, MBL2
41bartonellosis10.3CD40LG, TLR2
42immunoglobulin beta deficiency10.3CD40LG, MBL2
43rumination disorder10.3CD40LG, TLR2
44lymphoma10.3
45collagenous colitis10.3IL2, TNF
46hemorrhagic proctocolitis10.3CD40LG, TNF
47cogan-reese syndrome10.3CD40LG, TNF
48periodontal disease10.3MBL2, TLR2, TNF
49diffuse intraductal papillomatosis10.3CD40LG, TNF
50trachoma10.3MBL2, TLR2, TNF

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Symptoms for Rheumatic Fever

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Symptoms:

 51 (show all 36)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • acute abdominal pain/colic
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • pallor
  • absent/hypotonic/flaccid abdominal wall muscles
  • constipation
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding

Drugs & Therapeutics for Rheumatic Fever

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Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 66)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver ExtractsPhase 43572
2
MethotrexateapprovedPhase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
3
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
InfliximabapprovedPhase 3349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
5
Folic Acidapproved, nutraceuticalPhase 3292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6Antibodies, MonoclonalPhase 3, Phase 1, Phase 22413
7AntibodiesPhase 3, Phase 1, Phase 24477
8Interleukin 1 Receptor Antagonist ProteinPhase 2, Phase 335
9Peripheral Nervous System AgentsPhase 3, Phase 118510
10ImmunoglobulinsPhase 3, Phase 1, Phase 24477
11AntimetabolitesPhase 39454
12AnalgesicsPhase 39358
13Analgesics, Non-NarcoticPhase 35184
14Anti-Inflammatory AgentsPhase 38478
15Immunosuppressive AgentsPhase 310422
16Anti-Inflammatory Agents, Non-SteroidalPhase 33549
17Antirheumatic AgentsPhase 3, Phase 28496
18Gastrointestinal AgentsPhase 36401
19Immunologic FactorsPhase 3, Phase 218483
20Vitamin B ComplexPhase 32847
21Nucleic Acid Synthesis InhibitorsPhase 33836
22Folic Acid AntagonistsPhase 31643
23Antimetabolites, AntineoplasticPhase 35770
24Dermatologic AgentsPhase 34555
25Folinic AcidNutraceuticalPhase 32604
26Vitamin B9NutraceuticalPhase 32924
27FolateNutraceuticalPhase 32924
28
AcetylcysteineapprovedPhase 2293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
29N-monoacetylcystinePhase 2293
30Protective AgentsPhase 25651
31VaccinesPhase 26085
32Pharmaceutical SolutionsPhase 2, Phase 17004
33Respiratory System AgentsPhase 2, Phase 13931
34ExpectorantsPhase 2337
35Antiviral AgentsPhase 28071
36penicillinsPhase 292
37Anti-Infective AgentsPhase 217220
38AntioxidantsPhase 22442
39glutamineNutraceuticalPhase 2144
40alanineNutraceuticalPhase 2106
41
EpinephrineapprovedPhase 183451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
42
LidocaineapprovedPhase 11103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
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α-diethylamino-2,6-dimethylacetanilide
43Epinephryl boratePhase 1834
44Diuretics, Potassium SparingPhase 11445
45Sodium Channel BlockersPhase 11180
46Vasoconstrictor AgentsPhase 11303
47RacepinephrinePhase 1834
48Neurotransmitter AgentsPhase 114795
49MydriaticsPhase 1525
50Central Nervous System DepressantsPhase 110016

Interventional clinical trials:

(show top 50)    (show all 53)
idNameStatusNCT IDPhase
1A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)RecruitingNCT01734382Phase 4
2Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?CompletedNCT02164214Phase 3
3An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and WiCompletedNCT00891046Phase 3
4Study of the Safety and Efficacy of NC-503 in Secondary (AA) AmyloidosisCompletedNCT00035334Phase 2, Phase 3
5A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA)CompletedNCT00642460Phase 3
6Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITISCompletedNCT00339157Phase 2, Phase 3
7Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus PlaceboRecruitingNCT01068405Phase 3
8Infliximab Therapy in Patients With Refractory Polymyalgia RheumaticaActive, not recruitingNCT01423591Phase 3
9Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
10Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)CompletedNCT00001359Phase 2
11N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve ReplacementCompletedNCT01704482Phase 2
12Validity Study of Glutamine to Improve Cardiac Function in Cardiac SurgeryCompletedNCT01794884Phase 2
13Mild Water-Filtered Near Infrared Whole-Body-Hyperthermia as an Adjunct in the Treatment of FibromyalgiaCompletedNCT00324441Phase 2
14Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
15Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young AdultsCompletedNCT00534495Phase 2
16TIV and High Dose TIV in Subjects With Rheumatoid ArthritisCompletedNCT01436370Phase 2
17Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00426218Phase 1, Phase 2
18Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseRecruitingNCT02398435Phase 2
19Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic PatientNot yet recruitingNCT02020668Phase 2
20Efficacy and Safety of Tocilizumab in Adult's Still DiseaseNot yet recruitingNCT01002781Phase 2
21Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male VolunteersCompletedNCT01525147Phase 1
22Dental Anesthesia in Pregnant Women With Rheumatic Heart DiseaseCompletedNCT00482573Phase 1
23Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic FeverCompletedNCT01886846
24Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among SchoolchildrenCompletedNCT02353663
25Hospital Based Incidence of Group A Streptococcal Disease in FijiCompletedNCT00264771
26Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern TerritoryCompletedNCT00884728
27Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic DiseasesCompletedNCT01511341
28Genetic Susceptibility to Rheumatic Heart Disease in the Pacific RegionCompletedNCT02188862
29Surveillance of Streptococcal Infections in Children in IndiaCompletedNCT00342199
30Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence SurveyCompletedNCT01400529
31DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart DiseaseCompletedNCT00264524
32Effect of Simvastatin on Cardiac FunctionCompletedNCT01178710
33Deep Versus Superficial Heating in Patients With Knee OsteoarthritisCompletedNCT01343147
34Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory ArthritisCompletedNCT00796809
35The Genetic Basis of Acquired Heart Disease in AfricaRecruitingNCT02124109
36Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic TreatmentsRecruitingNCT01642706
37RhEumatiC Heart diseAse GeneticsRecruitingNCT02118818
38Rheumatic Heart Disease Study in LusakaRecruitingNCT02661763
39Rheumatic Heart Disease Prevalence in Leon, NicaraguaRecruitingNCT00307112
40Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium EnlargementRecruitingNCT02474108
41Yellow Fever Vaccination Under Low Dose Methotrexate TherapyRecruitingNCT02383680
42A Two-step Method Apparently Improved the Physicians' Level of Diagnosis Decision-making for Adult Patients With FUORecruitingNCT02035670
43American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
44Phenomics in Autoimmune and Inflammatory DiseasesRecruitingNCT02466217
45Rheumatic Heart Disease School ProjectActive, not recruitingNCT01550068
46Development of Intervention Model for Osteoporosis and Fall Prevention in TaiwanActive, not recruitingNCT01206491
47The Prevalence of Rheumatic Heart Disease in School Children in FijiActive, not recruitingNCT00779662
4841.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid DiseasesActive, not recruitingNCT00000106
49Juvenile Inflammatory Rheumatism (JIR) CohorteEnrolling by invitationNCT02377245
50Efficacy of BLIS K12 as Preventive Measure for Rheumatic ChildrenNot yet recruitingNCT02407106

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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MalaCards organs/tissues related to Rheumatic Fever:

33
Heart, Skin, Brain, Tonsil, Breast, Lung, Bone

Animal Models for Rheumatic Fever or affiliated genes

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MGI Mouse Phenotypes related to Rheumatic Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.4CD40LG, FCN1, HLA-DQA1, HP, IL2, MASP2

Publications for Rheumatic Fever

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Articles related to Rheumatic Fever:

(show top 50)    (show all 601)
idTitleAuthorsYear
1
A Clinico-Mycological Study on Suspected Cases of Chromoblastomycosis: Challenges in Diagnosis and Management. (26816977)
2015
2
Impact of monitoring longitudinal systolic strain changes during serial echocardiography on outcome in patients with AL amyloidosis. (26179863)
2015
3
Palpable purpura with foot drop: Common presentations in an uncommon disease. (25821734)
2015
4
Cortical Activation During Levitation and Tentacular Movements of Corticobasal Syndrome. (26559277)
2015
5
Common variant on MDM2 contributes to endometrial cancer susceptibility: evidence based on 7 studies. (24792886)
2014
6
EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia. (24989451)
2014
7
Ghanaian youth and festive transvestism. (23181350)
2013
8
Association between fluorescein leakage and optical coherence tomographic characteristics of microaneurysms in diabetic retinopathy. (23190917)
2013
9
Physiotherapy in cystic fibrosis: optimising techniques to improve outcomes. (24209461)
2013
10
Unanticipated intra-operative finding of pulmonary artery tumour thromboembolism during radical nephrectomy and caval thrombectomy: Case report and management. (23766846)
2013
11
Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review. (22157133)
2012
12
Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. (22739692)
2012
13
Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex. (21609714)
2011
14
Virus-specific CD8+ T-cell responses better define HIV disease progression than HLA genotype. (20147397)
2010
15
Construction of [Ag2X2]-based complexes from reactions of Ag(I) salts with N-diphenylphosphanylmethyl-4-aminopyridine: isolation, structures, and luminescent properties. (20390186)
2010
16
Diffusion-weighted MR imaging in postoperative follow-up: reliability for detection of recurrent cholesteatoma. (19231123)
2010
17
Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. (19429708)
2009
18
Epidermal growth factor receptor-dependent PI3K-activation promotes restitution of wounded human gastric epithelial monolayers. (17708540)
2008
19
Deoxyribonuclease activity and circulating DNA concentration in blood plasma of patients with prostate tumors. (18837950)
2008
20
Locally advanced prostate cancer: biochemical results from a prospective phase II study of intermittent androgen suppression for men with evidence of prostate-specific antigen recurrence after radiotherapy. (17559131)
2007
21
C/EBPalpha binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment. (17671233)
2007
22
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor. (17711846)
2007
23
The dichloromethane fraction of Stemona tuberosa Lour inhibits tumor cell growth and induces apoptosis of human medullary thyroid carcinoma cells. (19707315)
2007
24
Eosinophil chemoattractants and related factors in nasal polyps]. (17165591)
2006
25
Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. (16754660)
2006
26
Sheehan syndrome presented with acute renal failure associated with rhabdomyolysis and hyponatraemia. (16263736)
2006
27
Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. (15691849)
2005
28
Increased toll-like receptor 4 expression in thymus of myasthenic patients with thymitis and thymic involution. (15972959)
2005
29
A mechanism for death receptor discrimination by death adaptors. (16006552)
2005
30
The association between acute fatty liver of pregnancy and fatty acid oxidation disorders. (15673650)
2005
31
Cat-scratch disease presenting as a breast mass. (15307578)
2004
32
Extracellular matrix proteins protect pancreatic cancer cells from death via mitochondrial and nonmitochondrial pathways. (14517801)
2003
33
Bupropion treatment for cocaine abuse and adult attention-deficit/hyperactivity disorder. (11916368)
2002
34
Scabies presenting as a blistering eruption. (11710447)
2001
35
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. (11446442)
2001
36
The use of betamethasone and hyaluronidase injections in the treatment of Peyronie's disease. (11195899)
2000
37
Inhibition by parthenolide of phorbol ester-induced transcriptional activation of inducible nitric oxide synthase gene in a human monocyte cell line THP-1. (10874135)
2000
38
Training of junior rowers before world championships. Effects on performance, mood state and selected hormonal and metabolic responses. (11297003)
2000
39
Gene structure and function of the 2'-5'-oligoadenylate synthetase family. (11092454)
2000
40
Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells. (10623585)
2000
41
Acute hemorrhagic leukoencephalitis during treatment for disseminated tuberculosis in a patient with AIDS. (9487459)
1997
42
Molecular cloning of a cDNA encoding human ribosomal protein L39. (8764829)
1996
43
Wortmannin inhibits carcinogen-stimulated phosphorylation of ethanolamine and choline. (7843409)
1995
44
Chondrocalcin is identical with the C-propeptide of type II procollagen. (3800925)
1986
45
Morphologic significance of bifid uvula. (3975126)
1985
46
Collagenous colitis: the clinical and morphological features. (7122380)
1982
47
Lymphomatoid papulosis and other pseudomalignancies of the skin. (576506)
1977
48
Reactivity of human immunoglobulins in echinococcosis and trichinosis. (4170136)
1968
49
50

Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.6CD40LG, IL2
29.4IL2, TNF
39.4IL2, TNF
4
Show member pathways
9.4IL2, TNF
59.3CD40LG, TLR2, TNF
69.3CD40LG, TLR2, TNF
79.2IL2, MBL2, TNF
8
Show member pathways
9.1IL2, TLR2, TNF
9
Show member pathways
9.1CD40LG, IL2, TNF
109.1HLA-DQA1, MBL2, TLR2
119.1HLA-DQA1, MASP2, MBL2
12
Show member pathways
9.0FCN2, FCN3, MASP2, MBL2
138.8HLA-DQA1, TLR2, TNF
148.8HLA-DQA1, TLR2, TNF
15
Show member pathways
8.8CD40LG, IL2, TLR2, TNF
16
Show member pathways
8.6FCN1, FCN2, FCN3, MASP2, MBL2
17
Show member pathways
8.5CD40LG, HLA-DQA1, TLR2, TNF
18
Show member pathways
8.5CD40LG, HLA-DQA1, TLR2, TNF
19
Show member pathways
8.3HLA-DQA1, IL2, TLR2, TNF
20
Show member pathways
8.0CD40LG, HLA-DQA1, IL2, TLR2, TNF
21
Show member pathways
6.1CD40LG, FCN1, FCN2, FCN3, HLA-DQA1, IL2

GO Terms for genes affiliated with Rheumatic Fever

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Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.3TLR2, TNF
2negative regulation of growth of symbiont in hostGO:004413010.3MBL2, TNF
3regulation of immunoglobulin secretionGO:005102310.2CD40LG, TNF
4positive regulation of interferon-gamma productionGO:00327299.9IL2, TNF
5complement activation, lectin pathwayGO:00018679.7FCN2, FCN3, MASP2, MBL2
6defense response to Gram-positive bacteriumGO:00508309.5FCN2, MBL2, TLR2, TNF
7complement activationGO:00069569.4FCN1, FCN3, MASP2, MBL2
8immune responseGO:00069559.0IL2, TLR2, TNF
9proteolysisGO:00065088.0FCN1, FCN2, FCN3, HP, MBL2
10innate immune responseGO:00450877.8FCN1, FCN2, FCN3, IL2, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042528.9FCN1, FCN2, FCN3, MASP2

Sources for Rheumatic Fever

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet