MCID: RHM001
MIFTS: 65

Rheumatic Fever malady

Cardiovascular diseases, Bone diseases categories

Summaries for Rheumatic Fever

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to arthritis and glomerulonephritis, and has symptoms including cardiac valvulopathy, pericardium anomalies/pericarditis/absence/cysts/pericardial effusion and nephrotic syndrome. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Phagocytosis of Microbes and Immune response Lectin induced complement pathway. The drugs aspirin and choline salicylate and the compounds Palivizumab and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin.

Description from OMIM:46 268240

Aliases & Classifications for Rheumatic Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


Aliases & Descriptions:

rheumatic fever 8 42 10 44 48 46 60
acute rheumatic fever 8 42 44 48
rheumatic fever without mention of heart involvement 8
rheumatic fever without heart involvement 8
acute rheumatic arthritis 8
acute rheumatic fever nos 8
rheumatic fever, active 8
inflammatory rheumatism 42
active rheumatic fever 8
rhf - rheumatic fever 8


External Ids:

Disease Ontology8 DOID:1586
NCIt39 C34984
ICD9CM27 390-392.99
MeSH34 D012213
SNOMED-CT via Orphanet57 58718002
ICD10 via Orphanet26 I01.0, I00, I01.1 I01.2, I01.8, I01.9, more
UMLS via Orphanet61 C0035436
OMIM46 268240
MESH via Orphanet35 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TLR2, FCGR3B, FCGR2A
2glomerulonephritis30.7MBL2, FCGR2A
3kawasaki disease30.7ADM, MBL2
4acute poststreptococcal glomerulonephritis30.6SKA3, SKA2, SKA1
5systemic lupus erythematosus30.3FCGR3B, FCGR2A
6rheumatoid arthritis30.2TLR2, MBL2, FCGR3B, FCGR2A
7leukemia30.0FCGR3B, MBL2, TLR2
8endocarditis10.6
9reactive arthritis10.5
10scarlet fever10.5
11pharyngitis10.5
12rheumatic myocarditis10.5
13subacute bacterial endocarditis10.4
14obsessive-compulsive disorder10.3
15chorea minor10.3
16atrioventricular block10.3
17antiphospholipid syndrome10.3
18pulmonary edema10.3
19infective endocarditis10.3
20collagen disease10.2
21lupus erythematosus10.2
22pericarditis10.2
23purpura10.2
24sydenham's chorea10.2
25chronic rheumatic pericarditis10.2
26septic arthritis10.2
27rheumatic congestive heart failure10.2
28acute orbital inflammation10.2
29aortic valve stenosis10.2
30pyoderma10.2
31coronary artery disease10.1
32connective tissue disease10.1
33branch retinal artery occlusion10.0
34cardiac tamponade10.0
35decubitus ulcer10.0
36mitral valve prolapse10.0
37congenital heart block10.0
38hemoglobin c disease10.0
39iritis10.0
40familial mediterranean fever10.0
41nodular nonsuppurative panniculitis10.0
42mitral valve stenosis10.0
43diabetic ketoacidosis10.0
44osteonecrosis10.0
45subacute leukemia10.0
46erysipelas10.0
47henoch-schoenlein purpura10.0
48noonan syndrome10.0
49aseptic meningitis10.0
50rapidly progressive glomerulonephritis10.0

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Clinical Features for Rheumatic Fever

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

268240

Clinical synopsis from OMIM:

268240

Symptoms:

48 (show all 36)
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding
  • anorexia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • acute abdominal pain/colic
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • fever/chilling
  • arthritis/synovitis/synovial proliferation
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • pharyngitis
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • macules
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • constipation
  • absent/hypotonic/flaccid abdominal wall muscles
  • pallor
  • asthenia/fatigue/weakness
  • articular/joint pain/arthralgia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • cardiac rhythm disorder/arrhythmia
  • endocardium anomalies/fibroelastosis/endocarditis
  • myocardium anomalies/myocarditis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema

Drugs & Therapeutics for Rheumatic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rheumatic Fever

Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Search CenterWatch for Rheumatic Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rheumatic Fever:

32
Heart, Brain, Skin, Bone, Lung, B cells, T cells, Testes, Tonsil, Cardiac myocytes, Monocytes

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Sources:
50PubMed
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Articles related to Rheumatic Fever:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971). (23610223)
2013
2
Variability in disease burden and management of rheumatic fever and rheumatic heart disease in two regions of tropical Australia. (22646671)
2013
3
Acute rheumatic fever: case report and review for emergency physicians. (23910164)
2013
4
Mortality and hospitalisation costs of rheumatic fever and rheumatic heart disease in New Zealand. (22494452)
2012
5
The future of acute rheumatic fever and rheumatic heart disease in Australia. (22860775)
2012
6
Rheumatic Fever and postgroup-a streptococcal arthritis. (21490490)
2011
7
Clinical presentation of rheumatic fever in an endemic area. (19880393)
2010
8
Similar erythrocyte sedimentation rate and C-reactive protein sensitivities at the onset of septic arthritis, osteomyelitis, acute rheumatic fever. (21589835)
2010
9
The Irish contribution to the eradication of rheumatic fever. (20666061)
2010
10
Neurological burden of acute rheumatic fever and rheumatic heart disease: the case for action. (20398851)
2010
11
Rheumatic fever in Kosoava--long-term study. (20088183)
2009
12
Streptococcal emm types in Hawaii: a region with high incidence of acute rheumatic fever. (19057463)
2009
13
Determination of group a streptococcal anti-M type-specific antibody in sera of rheumatic fever patients after 45 years. (19761409)
2009
14
High incidence of rheumatic fever and rheumatic heart disease in the republics of Central Asia. (20374323)
2009
15
Preventing rheumatic fever--new guidelines. (19530261)
2009
16
Rheumatic fever: neglected again. (19342571)
2009
17
Autoantigens identified by screening a human heart cDNA library with acute rheumatic fever sera. (19758136)
2009
18
The willow as a Hottentot (Khoikhoi) remedy for rheumatic fever. (18515781)
2008
19
An unusual case of acute rheumatic fever presenting with unilateral pulmonary edema. (19227426)
2008
20
Group A streptococcal isolates temporally associated with acute rheumatic fever in Hawaii: differences from the continental United States. (17599299)
2007
21
Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. (17079017)
2007
22
The Drakensberg declaration on the control of rheumatic fever and rheumatic heart disease in Africa. (16610104)
2006
23
Percutaneous transvenous mitral commissurotomy in patients with severe mitral stenosis and acute rheumatic fever. (16598628)
2006
24
Chronic post-rheumatic fever (Jaccoud's) arthropathy involving carpometacarpal joints. (16908697)
2006
25
Antibody responses to group A streptococcal infections in acute rheumatic fever. (16940843)
2006
26
Acute rheumatic fever: an unusual cause of fever in a returned traveler. (16343390)
2005
27
Adult-onset acute rheumatic fever: possible resurgence in southern Taiwan. (16357733)
2005
28
Acute rheumatic fever. (16005340)
2005
29
Rheumatic fever in the 21st century. (15680061)
2004
30
Molecular characterization of Streptococcus pyogenes isolates collected during periods of increased acute rheumatic fever activity in Utah. (14743048)
2004
31
Syncope in a middle aged male due to acute rheumatic fever. (15751526)
2004
32
Treating acute rheumatic fever. (14500407)
2003
33
Nitric oxide metabolities in acute rheumatic fever. (12703657)
2003
34
Serum cardiac troponin I in acute rheumatic fever. (12450620)
2002
35
Acute rheumatic fever: whither steroids? (12462662)
2002
36
Association of pyrogenic exotoxin genes with pharyngitis and rheumatic fever/rheumatic heart disease among Indian isolates of Streptococcus pyogenes. (12180948)
2002
37
Time to take soundings in acute rheumatic fever. (11438128)
2001
38
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
39
High pharyngeal carriage rates of Streptococcus pyogenes in Dunedin school children with a low incidence of rheumatic fever. (11198543)
2000
40
Osteonecrosis of the femoral head after acute rheumatic Fever. (19078493)
2000
41
Urticarial eruption associated with rheumatic fever in a child. (10469414)
1999
42
Pioneers and modern ideas. Rheumatic fever--a half-century perspective. (9719793)
1998
43
Acute rheumatic fever (ARF) in non-aboriginal patients in the Northern Territory. (9544393)
1998
44
Obsessive-compulsive and related symptoms in children and adolescents with rheumatic fever with and without chorea: a prospective 6-month study. (9699708)
1998
45
Acute rheumatic fever with three major criteria: polyarthritis, carditis and chorea. A case report. (10028869)
1998
46
Rapidly progressive glomerulonephritis complicating acute rheumatic fever. (7479469)
1995
47
Lymphocyte subsets and plasma IL-1 alpha, IL-2, and TNF-alpha concentrations in acute rheumatic fever and chronic rheumatic heart disease. (7586724)
1995
48
Haptoglobin in rheumatic fever. (8935147)
1995
49
Antibodies reactive with streptococcal peptidoglycan-polysaccharide complexes in rheumatic fever, subacute bacterial endocarditis and tuberculosis. (3280503)
1988
50
Scarlet fever (convalescent); acute rheumatic fever. (20293758)
1947

Genetic Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Sources:
51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Rheumatic Fever

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Sources:
11DrugBank, 49PharmGKB, 44Novoseek, 24HMDB, 28IUPHAR
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Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1Palivizumab1110.6FCGR3B, FCGR2A
2Intravenous Immunoglobulin1110.6FCGR2A, FCGR3B
3Ibritumomab1110.6FCGR3B, FCGR2A
4bevacizumab49 1111.6FCGR3B, FCGR2A
5tositumomab49 1111.5FCGR3B, FCGR2A
6n-acetylglucosamine4410.5FCN1, FCN2, MBL2
7alefacept44 1111.5FCGR3B, FCGR2A
8efalizumab44 1111.5FCGR2A, FCGR3B
9nadph44 2411.5TLR2, PGD, FCGR2A, ADM
10mannan4410.5FCN2, FCN3, MASP2, MBL2, TLR2
11Muromonab1110.4FCGR2A, FCGR3B
12daclizumab44 1111.4FCGR3B, FCGR2A
13mannose4410.4TLR2, MBL2, MASP2, FCGR3B, FCGR2A
14serine4410.4FCGR2A, FCGR3B, MASP2, EGR3, TLR2
15superoxide44 2411.4ADM, FCGR3B, PGD, MBL2, TLR2
16basiliximab44 1111.4FCGR2A, FCGR3B
17polysaccharide4410.3TLR2, MBL2, FCN3, FCGR3B, FCGR2A, FCN2
18fibrinogen4410.3TLR2, MBL2, MASP2, MYOM2, FCN2, FCN1
19gemtuzumab ozogamicin44 1111.3FCGR3B, FCGR2A
20natalizumab44 1111.3FCGR2A, FCGR3B
21h2o24410.3ADM, FCGR2A, FCGR3B, PGD, TLR2
22prednisolone44 28 1112.1FCGR2A, FCGR3B, MBL2
23alemtuzumab44 1111.0FCGR2A, FCGR3B

GO Terms for genes affiliated with Rheumatic Fever

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16Gene Ontology
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Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:00094010.1SKA1, SKA3, SKA2
2collagenGO:00558110.0FCN1, FCN2, FCN3, MBL2
3extracellular regionGO:0055769.9ADM, FCN1, FCN2, FCGR3B, FCN3, MASP2
4spindle microtubuleGO:0058769.8SKA2, SKA3, SKA1

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MBL2, TLR2
2opsonizationGO:00822810.3FCN1, FCN2, MBL2
3complement activation, lectin pathwayGO:00186710.2FCN1, FCN2, FCN3, MASP2, MBL2
4complement activationGO:00695610.2MBL2, MASP2, FCN3, FCN2, FCN1
5regulation of microtubule polymerization or depolymerizationGO:03111010.1SKA2, SKA3, SKA1
6chromosome segregationGO:0070599.8SKA1, SKA3, SKA2
7innate immune responseGO:0450879.8TLR2, MBL2, MASP2, FCN3, FCGR2A, FCN2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.3FCGR2A, FCGR3B
2calcium-dependent protein bindingGO:04830610.1FCN2, MASP2, MBL2
3protein bindingGO:0055158.9TLR2, MBL2, AKAP17A, MASP2, MYOM2, SKA2

Products for genes affiliated with Rheumatic Fever

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Rheumatic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet