MCID: RHM001
MIFTS: 66

Rheumatic Fever malady

Rare diseases, Cardiovascular diseases, Bone diseases categories
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Summaries for Rheumatic Fever

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Wikipedia:65 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards based summary: Rheumatic Fever, also known as acute rheumatic fever, is related to rheumatic congestive heart failure and systemic lupus erythematosus, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, macules and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Complement and coagulation cascades and Phagocytosis of Microbes. The drugs aspirin and choline salicylate and the compounds zymosan and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin.

Description from OMIM:46 268240

Aliases & Classifications for Rheumatic Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Rheumatic Fever, Aliases & Descriptions:

Name: Rheumatic Fever 8 42 10 44 48 46 62
Acute Rheumatic Fever 8 42 44 48 62
Rheumatic Fever Without Mention of Heart Involvement 8 62
Rheumatic Fever Without Heart Involvement 8 62
Inflammatory Rheumatism 42 62
Active Rheumatic Fever 8 62
 
Rhf - Rheumatic Fever 8 62
Arthritis, Rheumatic, Acute 62
Acute Rheumatic Arthritis 8
Acute Rheumatic Fever Nos 8
Rheumatic Fever, Active 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


External Ids:

Disease Ontology8 DOID:1586
MeSH34 D012213
ICD9CM27 390-392.99
NCIt39 C34984
ICD10 via Orphanet26 I01.2, I01.8, I01.9 I00, I01.0, I01.1, more
UMLS via Orphanet63 C0035436
OMIM46 268240
MESH via Orphanet35 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatic congestive heart failure31.0MBL2
2systemic lupus erythematosus30.7FCGR3B
3meningitis30.4MBL2, TLR2
4vasculitis30.2MBL2, FCGR3B
5rheumatoid arthritis29.9MBL2, FCGR3B, TLR2
6rheumatic disease10.8
7arthritis10.7
8endocarditis10.7
9chorea10.6
10scarlet fever10.6
11glomerulonephritis10.6
12pharyngitis10.6
13reactive arthritis10.6
14rheumatic myocarditis10.6
15kawasaki disease10.5
16sydenham's chorea10.5
17subacute bacterial endocarditis10.4
18malaria10.4TLR2
19antiphospholipid syndrome10.4
20acute poststreptococcal glomerulonephritis10.4
21chorea minor10.4
22pulmonary edema10.4
23infective endocarditis10.4
24septic arthritis10.3
25atrioventricular block10.3
26collagen disease10.3
27lupus erythematosus10.3
28pericarditis10.3
29purpura10.3
30neisseria meningitidis infection10.3MBL2, TLR2
31aspergillosis10.3MBL2, TLR2
32bronchiectasis10.3MBL2, TLR2
33otitis media10.2MBL2, TLR2
34pulmonary tuberculosis10.2TLR2, MBL2
35hepatitis b10.2TLR2, MBL2
36chronic rheumatic pericarditis10.2
37tonsillitis10.2
38acute orbital inflammation10.2
39aortic valve stenosis10.2
40congenital heart disease10.2
41pyoderma10.2
42syncope10.2
43connective tissue disease10.2
44septic shock10.1TLR2, MBL2
45peritonitis10.1FCGR3B, TLR2
46allergic rhinitis10.1MBL2, TLR2
47neutropenia10.1FCGR3B, MBL2
48congenital heart block10.1
49diabetes mellitus10.1
50glycogen storage disease10.1

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Symptoms for Rheumatic Fever

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Symptoms by clinical synopsis from OMIM:

268240

Clinical features from OMIM:

268240

Symptoms:

48 (show all 36)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • acute abdominal pain/colic
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • pallor
  • absent/hypotonic/flaccid abdominal wall muscles
  • constipation
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding

HPO human phenotypes related to Rheumatic Fever:

(show all 31)
id Description Frequency HPO Source Accession
1 hypermelanotic macule hallmark (90%) HP:0001034
2 arthritis hallmark (90%) HP:0001369
3 nausea and vomiting hallmark (90%) HP:0002017
4 anorexia hallmark (90%) HP:0002039
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 recurrent pharyngitis hallmark (90%) HP:0100776
7 sinusitis typical (50%) HP:0000246
8 pallor typical (50%) HP:0000980
9 abnormality of the mitral valve typical (50%) HP:0001633
10 abnormality of the myocardium typical (50%) HP:0001637
11 abnormality of the aortic valve typical (50%) HP:0001646
12 abdominal pain typical (50%) HP:0002027
13 chorea typical (50%) HP:0002072
14 arthralgia typical (50%) HP:0002829
15 abnormality of the endocardium typical (50%) HP:0004306
16 arrhythmia typical (50%) HP:0011675
17 chest pain typical (50%) HP:0100749
18 nephrotic syndrome occasional (7.5%) HP:0000100
19 epistaxis occasional (7.5%) HP:0000421
20 behavioral abnormality occasional (7.5%) HP:0000708
21 gait disturbance occasional (7.5%) HP:0001288
22 abnormality of the pericardium occasional (7.5%) HP:0001697
23 constipation occasional (7.5%) HP:0002019
24 migraine occasional (7.5%) HP:0002076
25 respiratory insufficiency occasional (7.5%) HP:0002093
26 abnormality of the pleura occasional (7.5%) HP:0002103
27 neurological speech impairment occasional (7.5%) HP:0002167
28 aplasia/hypoplasia of the abdominal wall musculature occasional (7.5%) HP:0010318
29 hemiballismus occasional (7.5%) HP:0100248
30 fever HP:0001945
31 abnormality of the immune system HP:0002715

Drugs & Therapeutics for Rheumatic Fever

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Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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MalaCards organs/tissues related to Rheumatic Fever:

32
Heart, Brain, Skin, Bone, Lung, T cells, B cells, Testes, Tonsil, Neutrophil, Monocytes, Cardiac myocytes

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Articles related to Rheumatic Fever:

(show top 50)    (show all 557)
idTitleAuthorsYear
1
Primary prevention of rheumatic fever in children: key factors to consider. (24897809)
2014
2
Clinically manifested myocarditis in acute rheumatic fever. (24676379)
2014
3
Accelerated junctional rhythm in children with acute rheumatic fever: is it specific to the disease? (23694767)
2013
4
Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971). (23610223)
2013
5
Adult-onset acute rheumatic fever. (23037480)
2012
6
Rheumatic Fever Follow-Up Study (RhFFUS) protocol: a cohort study investigating the significance of minor echocardiographic abnormalities in Aboriginal Australian and Torres Strait Islander children. (23186515)
2012
7
Rheumatic fever recurrence prevention: a nurse-led programme of 28-day penicillin in an area of high endemnicity. (21470327)
2011
8
Complete heart block complicating Acute Rheumatic Fever. (22085189)
2011
9
Persistence of acute rheumatic fever in a tertiary children's hospital. (21199062)
2011
10
Health-related quality of life of school- age children with rheumatic Fever. (21244818)
2010
11
Clinical presentation of rheumatic fever in an endemic area. (19880393)
2010
12
Underdiagnosis of acute rheumatic fever in primary care settings in a developing country. (19735369)
2009
13
Surgical repositioning of a traumatically intruded permanent incisor in a patient with rheumatic fever: case report. (19208001)
2009
14
School-based prevention of acute rheumatic fever: a group randomized trial in New Zealand. (19710585)
2009
15
Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever. (18400635)
2008
16
Rheumatic fever in a 2-year-old child. (17952489)
2008
17
What is the true frequency of carditis in acute rheumatic fever? A prospective clinical and Doppler blind study of 56 children with up to 60 months of follow-up evaluation. (18825449)
2008
18
The willow as a Hottentot (Khoikhoi) remedy for rheumatic fever. (18515781)
2008
19
Rheumatic fever and social justice. (17547542)
2007
20
Management of patients with rheumatic fever and rheumatic heart disease in Nigeria--need for a national system of primary, secondary and tertiary prevention. (16607438)
2006
21
Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)
2006
22
Obsessive-compulsive symptoms in adults with rheumatic fever. (16774666)
2006
23
Activity of lipid peroxidation processes and the condition of antioxidative defense system in children with rheumatic fever]. (16308440)
2005
24
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)
2005
25
Inverse relationship between the ratio of ICAM-1 expressing lymphocytes and serum TGF-beta 1 concentrations in acute rheumatic fever. (16023325)
2005
26
Is it possible to prevent rheumatic fever? (15751529)
2004
27
Rheumatic fever. (15522676)
2004
28
Acute rheumatic fever in children: recognition and treatment. (15612837)
2004
29
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review. (12768947)
2003
30
Serum cardiac troponin I in acute rheumatic fever. (12450620)
2002
31
Current issues in the prevention of rheumatic fever. (12410170)
2002
32
The potential for vaccine development against rheumatic fever. (11999099)
2002
33
Can we eradicate rheumatic fever in the 21st century? (11428492)
2001
34
Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. (11380924)
2001
35
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
36
Prophylactic efficiency of 3-weekly benzathine penicillin G in rheumatic fever. (10838716)
2000
37
The psychiatric symptoms of rheumatic fever. (11097972)
2000
38
Urticarial eruption associated with rheumatic fever in a child. (10469414)
1999
39
T. Duckett Jones and his criteria for the diagnosis of acute rheumatic fever. (9926367)
1999
40
Rheumatic fever chemoprophylaxis in adults. (12152837)
1998
41
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
42
Advanced atrioventricular block in a 39-year-old man with acute rheumatic fever. (9826853)
1998
43
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
44
Search for linkage disequilibrium between alleles in the T cell receptor alpha and beta chain loci and susceptibility to rheumatic fever. (7493775)
1995
45
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
46
Release of oxygen free radicals by macrophages and neutrophils in patients with rheumatic fever. (1915447)
1991
47
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
48
Rheumatic fever as a collagen disease. (13339200)
1956
49
Rheumatic fever as a collagen disease. (13229241)
1954
50
Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. (14780325)
1950

Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

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Pathways for genes affiliated with Rheumatic Fever

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Compounds for genes affiliated with Rheumatic Fever

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Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1zymosan4410.0MBL2, TLR2
2polymyxin b449.9MBL2, TLR2
3lipoteichoic acid449.9MBL2, TLR2
4anti-fungal449.9TLR2, MBL2
5peptidoglycan44 2810.9MBL2, TLR2
6latex449.8MBL2, TLR2
7n-acetylglucosamine449.7FCN2, MBL2
8agarose449.7MBL2, TLR2
9leukotriene b444 61 2411.6FCGR3B, TLR2
10sialic acid449.5MBL2, FCN2
11prednisolone44 28 1111.5FCGR3B, MBL2
12carbohydrates449.3MBL2, MASP2
13superoxide44 2410.3TLR2, FCGR3B, MBL2
14fibrinogen448.9TLR2, FCN2, MASP2, MBL2
15mannose448.9MBL2, MASP2, FCGR3B, TLR2
16mannan448.5MBL2, MASP2, FCN3, FCN2, TLR2
17polysaccharide448.4TLR2, FCGR3B, FCN2, FCN3, MBL2
18calcium44 50 24 1111.3TLR2, FCGR3B, FCN2, MASP2, MBL2
19serine447.1TLR2, FCGR3B, FCN2, FCN3, MASP2, MBL2

GO Terms for genes affiliated with Rheumatic Fever

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Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5FCN3, FCN2
2collagenGO:0055819.0MBL2, FCN3, FCN2
3extracellular regionGO:0055767.7FCGR3B, FCN2, FCN3, MASP2, MBL2

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.6TLR2, MBL2
2opsonizationGO:0082289.6MBL2, FCN2
3complement activation, classical pathwayGO:0069589.6MBL2, MASP2
4defense response to Gram-positive bacteriumGO:0508309.4MBL2, TLR2
5complement activation, lectin pathwayGO:0018678.8MBL2, MASP2, FCN3, FCN2
6complement activationGO:0069568.7FCN2, FCN3, MASP2, MBL2
7innate immune responseGO:0450878.3TLR2, FCN2, FCN3, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.5FCN3, FCN2
2calcium-dependent protein bindingGO:0483068.8MBL2, MASP2, FCN2

Products for genes affiliated with Rheumatic Fever

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Sources for Rheumatic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet