MCID: RHM001
MIFTS: 59

Rheumatic Fever

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Rheumatic Fever

Summaries for Rheumatic Fever

NIH Rare Diseases : 49 Rheumatic fever is an inflammatory condition that may develop after infection with group A Streptococcus bacteria, such as strep throat or scarlet fever. It is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. Early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. Some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. It is not clear why some people who are infected with group A Streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. Treatment usually includes antibiotics and/or anti-inflammatory medications. Last updated: 1/11/2015

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to rheumatic disease and rheumatic heart disease, and has symptoms including nephrotic syndrome, sinusitis and epistaxis. An important gene associated with Rheumatic Fever is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Methotrexate and Etanercept have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotype is immune system.

Wikipedia : 72 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 rheumatic disease 30.9 CD40LG HLA-DRB1 TNF
2 rheumatic heart disease 30.3 HLA-DRB1 MASP2 MBL2 MYOM2 TLR2 TNF
3 berylliosis 30.1 HLA-DRB1 IL2
4 toxic shock syndrome 29.9 IL2 MYOM2 TNF
5 takayasu arteritis 29.8 CD40LG HLA-DRB1 TNF
6 mycobacterium tuberculosis 1 29.8 MBL2 TLR2 TNF
7 brucellosis 29.7 CD40LG IL2 TNF
8 meningitis 29.3 CD40LG MBL2 TLR2 TNF
9 rheumatoid arthritis 29.1 CD40LG HLA-DRB1 IL2 TLR2 TNF
10 autoimmune disease 29.1 CD40LG HLA-DRB1 IL2 MBL2 TNF
11 systemic lupus erythematosus 28.5 CD40LG FCN3 HLA-DRB1 IL2 MBL2 TNF
12 rheumatic fever-related antigen 12.5
13 sydenham chorea 11.9
14 rheumatic myocarditis 11.6
15 acute articular rheumatism 11.4
16 choreatic disease 11.3
17 aortic valve disease 2 11.3
18 rheumatic encephalitis 11.1
19 heart disease 10.7
20 beryllium disease 10.5 HLA-DRB1 TNF
21 microscopic polyangiitis 10.5 HLA-DRB1 TNF
22 chronic beryllium disease 10.5 HLA-DRB1 TNF
23 autoimmune pancreatitis 10.5 HLA-DRB1 TNF
24 lichen sclerosus 10.5 HLA-DRB1 TNF
25 oral tuberculosis 10.5 IL2 TNF
26 actinic prurigo 10.5 HLA-DRB1 TNF
27 vulvar vestibulitis syndrome 10.5 MBL2 TNF
28 adult dermatomyositis 10.5 MBL2 TNF
29 autoimmune myocarditis 10.5 IL2 TNF
30 sympathetic ophthalmia 10.5 HLA-DRB1 TNF
31 poems syndrome 10.5 MYOM2 TNF
32 recurrent respiratory papillomatosis 10.4 HLA-DRB1 IL2
33 farmer's lung 10.4 IL2 TNF
34 rheumatoid vasculitis 10.4 HLA-DRB1 TNF
35 clonorchiasis 10.4 IL2 TNF
36 prosthetic joint infection 10.4 MBL2 TLR2
37 crohn's colitis 10.4 IL2 TNF
38 haemophilus influenzae 10.4 TLR2 TNF
39 encephalitozoonosis 10.4 CD40LG TNF
40 rheumatoid lung disease 10.4 CD40LG TNF
41 miller fisher syndrome 10.4 CD40LG TNF
42 listeriosis 10.4 MBL2 TNF
43 penicilliosis 10.4 TLR2 TNF
44 burning mouth syndrome 10.4 IL2 TNF
45 mononeuritis of upper limb and mononeuritis multiplex 10.4 CD40LG MYOM2
46 immunoglobulin g deficiency 10.4 CD40LG MBL2
47 arthritis 10.4
48 polyclonal hypergammaglobulinemia 10.4 CD40LG MYOM2
49 chronic polyneuropathy 10.3 CD40LG MYOM2
50 mycobacterium abscessus 10.3 TLR2 TNF

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Human phenotypes related to Rheumatic Fever:

31 (show all 34)
# Description HPO Frequency HPO Source Accession
1 nephrotic syndrome 31 occasional (7.5%) HP:0000100
2 sinusitis 31 frequent (33%) HP:0000246
3 epistaxis 31 occasional (7.5%) HP:0000421
4 behavioral abnormality 31 occasional (7.5%) HP:0000708
5 pallor 31 frequent (33%) HP:0000980
6 gait disturbance 31 occasional (7.5%) HP:0001288
7 arthritis 31 hallmark (90%) HP:0001369
8 subcutaneous nodule 31 hallmark (90%) HP:0001482
9 abnormal mitral valve morphology 31 frequent (33%) HP:0001633
10 abnormal aortic valve morphology 31 frequent (33%) HP:0001646
11 pericarditis 31 occasional (7.5%) HP:0001701
12 fever 31 frequent (33%) HP:0001945
13 nausea and vomiting 31 hallmark (90%) HP:0002017
14 constipation 31 occasional (7.5%) HP:0002019
15 abdominal pain 31 frequent (33%) HP:0002027
16 anorexia 31 hallmark (90%) HP:0002039
17 chorea 31 frequent (33%) HP:0002072
18 migraine 31 occasional (7.5%) HP:0002076
19 respiratory insufficiency 31 occasional (7.5%) HP:0002093
20 abnormality of the pleura 31 occasional (7.5%) HP:0002103
21 fasciculations 31 occasional (7.5%) HP:0002380
22 arthralgia 31 frequent (33%) HP:0002829
23 aplasia/hypoplasia of the abdominal wall musculature 31 occasional (7.5%) HP:0010318
24 dyslexia 31 occasional (7.5%) HP:0010522
25 dysgraphia 31 occasional (7.5%) HP:0010526
26 erythema 31 occasional (7.5%) HP:0010783
27 arrhythmia 31 frequent (33%) HP:0011675
28 fatigue 31 frequent (33%) HP:0012378
29 macule 31 hallmark (90%) HP:0012733
30 myocarditis 31 frequent (33%) HP:0012819
31 hemiballismus 31 occasional (7.5%) HP:0100248
32 endocarditis 31 frequent (33%) HP:0100584
33 chest pain 31 frequent (33%) HP:0100749
34 recurrent pharyngitis 31 frequent (33%) HP:0100776

MGI Mouse Phenotypes related to Rheumatic Fever:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD40LG FCN1 HP IL2 MASP2 MBL2

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
2
Etanercept Approved, Investigational Phase 3 185243-69-0
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Rivaroxaban Approved Phase 3 366789-02-8
5
Warfarin Approved Phase 3 81-81-2 54678486 6691
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
7
leucovorin Approved, Nutraceutical Phase 3 58-05-9 143 6006
8
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
9
Phytonadione Approved, Investigational, Nutraceutical Phase 3 84-80-0 5284607 4812
10 Antimetabolites Phase 3
11 Antimetabolites, Antineoplastic Phase 3
12 Antirheumatic Agents Phase 3
13 Dermatologic Agents Phase 3
14 Folic Acid Antagonists Phase 3
15 Immunosuppressive Agents Phase 3
16 Nucleic Acid Synthesis Inhibitors Phase 3
17 Vitamin B Complex Phase 3
18 Analgesics Phase 3
19 Analgesics, Non-Narcotic Phase 3
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 Anti-Inflammatory Agents, Non-Steroidal Phase 3
22 Gastrointestinal Agents Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
24 Natriuretic Peptide, Brain Phase 2, Phase 3
25 HIV Protease Inhibitors Phase 3,Phase 2
26
protease inhibitors Phase 3,Phase 2
27 Anticoagulants Phase 3
28 Antifibrinolytic Agents Phase 3
29 Antipyretics Phase 3
30 Antithrombin III Phase 3
31 Antithrombins Phase 3
32 Coagulants Phase 3
33 Cyclooxygenase Inhibitors Phase 3
34 Factor Xa Inhibitors Phase 3
35 Fibrinolytic Agents Phase 3
36 Hemostatics Phase 3
37 Micronutrients Phase 3
38 Platelet Aggregation Inhibitors Phase 3
39 Serine Proteinase Inhibitors Phase 3
40 Trace Elements Phase 3
41 Vitamins Phase 3
42 Folate Nutraceutical Phase 3
43 Vitamin B9 Nutraceutical Phase 3
44 Menaquinone Nutraceutical Phase 3
45 naphthoquinone Nutraceutical Phase 3
46 serine Nutraceutical Phase 3
47 Vitamin K Nutraceutical Phase 3
48
Acetylcysteine Approved, Investigational Phase 2 616-91-1 12035
49
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
50
Penicillin G Approved, Vet_approved Phase 2 61-33-6 5904

Interventional clinical trials:

(show top 50) (show all 51)

# Name Status NCT ID Phase Drugs
1 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3 Methotrexate;Placebo
2 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3 etanercept Treatment
3 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
4 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3 Rivaroxaban (20 mg);Vitamin K antagonists (VKA)
5 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3 Rivaroxaban (15 mg);Aspirin
6 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
7 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2 Penicillin or Placebo
8 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2 Glutamine;Ringer's solution
9 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2 N-acetylcysteine;placebo
10 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2 Probiotic Agent;Dexamethasone
11 Determining the Impact of Penicillin in Latent RHD: The GOAL Trial Not yet recruiting NCT03346525 Phase 2 intramuscular benzathine penicillin G (BPG) prophylaxis
12 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
13 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
14 Controlled Human Infection for Vaccination Against Streptococcus Pyogenes Not yet recruiting NCT03361163 Phase 1
15 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106
16 Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic Treatments Unknown status NCT01642706
17 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
18 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
19 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
20 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
21 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
22 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
23 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
24 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341
25 Guided Self-Management Intervention Targeting Fatigue in Rheumatic Inflammatory Diseases Completed NCT03216616
26 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
27 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
28 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
29 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689 TNF-alpha antagonist and other biotherapy
30 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
31 Effect of Simvastatin on Cardiac Function Completed NCT01178710 Simvastatin
32 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
33 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
34 Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement Completed NCT02474108
35 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524
36 Cardiovascular Risk and Chronic Inflammatory Rheumatism Recruiting NCT03187444
37 Study Medication Adherence and Its Determinants in Chronic Disease Through the Example of Methotrexate in Chronic Inflammatory Rheumatism Recruiting NCT02926560
38 Prospective Follow-up of Patients With Chronic Inflammatory Rheumatism Recruiting NCT03076866
39 Rheumatic Heart Disease School Project Recruiting NCT01550068
40 The Genetic Basis of Acquired Heart Disease in Africa Recruiting NCT02124109
41 RhEumatiC Heart diseAse Genetics Recruiting NCT02118818
42 Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients Recruiting NCT03306784
43 Sarcopenia in Axial and Peripheral Spondyloarthropathies Recruiting NCT03319264
44 Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients Recruiting NCT03095937
45 Speckle Tracking for Timing of Surgical Operation in Severe Mitral Regurge Recruiting NCT03156972
46 Juvenile Inflammatory Rheumatism (JIR) Cohorte Enrolling by invitation NCT02377245
47 Prevalence of Secondary Cardiac Damage in Rheumatic Fever Patients and Penicillin Secondary Prophylaxis Not yet recruiting NCT03183180
48 Clinical Audit on the Managment in Assiut University Children Hospital Not yet recruiting NCT03281863
49 Fertility Study of Women With Chronic Inflammatory Rheumatism Not yet recruiting NCT03452735
50 Use of Remote Monitoring by Smartphone in the Care Management of Patients With Rheumatoid Arthritis Not yet recruiting NCT03005925

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

38
Heart, Skin, Brain, Tonsil, B Cells, Monocytes, Bone

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 680)
# Title Authors Year
1
Transition to adult care for Aboriginal children with rheumatic fever: a review informed by a focussed ethnography in northern Australia. ( 29310752 )
2018
2
Rheumatic fever: The rebound phenomenon returns. ( 29411467 )
2018
3
Acute rheumatic fever presenting as complete heart block: report of an adolescent case and review of literature. ( 29440244 )
2018
4
Estimating the likely true changes in rheumatic fever incidence using two data sources. ( 29208066 )
2018
5
Scabies is strongly associated with acute rheumatic fever in a cohort study of Auckland children. ( 29442387 )
2018
6
Aboriginal children and penicillin injections for rheumatic fever: how much of a problem is injection pain? ( 29168304 )
2018
7
The novel Group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute rheumatic fever. ( 29269013 )
2017
8
Erratum in: Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 28584595 )
2017
9
Enablers and barriers to secondary prophylaxis for rheumatic fever among MA8ori aged 14-21 in New Zealand: a framework method study. ( 29149897 )
2017
10
Is a rheumatic fever register the best surveillance tool to evaluate rheumatic fever control in the Auckland region? ( 28796771 )
2017
11
Rheumatic fever as an indicator of child health. ( 28796766 )
2017
12
Using preceding hospital admissions to identify children at risk of developing acute rheumatic fever. ( 29168244 )
2017
13
Prescribing for people with acute rheumatic fever. ( 28507400 )
2017
14
Can We Eliminate Rheumatic Fever and Premature Deaths From RHD? ( 28552220 )
2017
15
Clinical presentation and outcomes of patients with acute rheumatic fever and rheumatic heart disease seen at a tertiary hospital setting in Port Elizabeth, South Africa. ( 28430286 )
2017
16
Rheumatic Fever Presenting as Recurrent Pericarditis and Cardiac Tamponade. ( 28720034 )
2017
17
Acute rheumatic fever: clinical profile in children in western Ukraine. ( 28616087 )
2017
18
Acute rheumatic fever and isolated myocarditis. ( 28560960 )
2017
19
Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm Mimicking Acute Rheumatic Fever: Report of an Unusual Clinical Presentation and Review of Literature. ( 28859047 )
2017
20
Penicillin Dried Blood Spot Assay for Use in Patients Receiving Intramuscular Benzathine Penicillin G and Other Penicillin Preparations To Prevent Rheumatic Fever. ( 28559267 )
2017
21
Rheumatic fever: update on the Jones criteria according to the American Heart Association review - 2015. ( 28743364 )
2017
22
Ventricular dyssynchrony as a marker of latent carditis in children with acute rheumatic fever: A tissue Doppler imaging. ( 29067722 )
2017
23
Emm type distribution of group A streptococcus isolates from the throat swabs of children living in areas with a high (Northland and Gisborne) or low (Palmerston North) incidence of acute rheumatic fever. ( 28796768 )
2017
24
Eliminating acute rheumatic fever and rheumatic heart disease. ( 28721865 )
2017
25
Atypical Articular Presentations in Indian Children with Rheumatic Fever. ( 28528779 )
2017
26
Evaluation of vitamin D levels in patients with acute rheumatic fever. ( 28680013 )
2017
27
Association of rheumatic fever & rheumatic heart disease with plausible early & late-stage disease markers. ( 29067978 )
2017
28
Acute rheumatic fever outbreak in southern central European country. ( 27815733 )
2017
29
WhA8nau perceptions and experiences of acute rheumatic fever diagnosis for MA8ori in Northland, New Zealand. ( 29121626 )
2017
30
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
31
Clinical management and patient persistence with antibiotic course in suspected group A streptococcal pharyngitis for primary prevention of rheumatic fever: the perspective from a New Zealand emergency department. ( 28617790 )
2017
32
Atrial fibrillation 50 years after acute rheumatic fever as the first manifestation of rheumatic mitral stenosis. ( 28405095 )
2017
33
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
34
MBL2 and FCN2 gene polymorphisms in a cohort of Italian children with rheumatic fever: A case-control study. ( 28576308 )
2017
35
WHAT IS ACUTE RHEUMATIC FEVER (ARF) AND RHEUMATIC HEART DISEASE (RHD)? ( 27132395 )
2016
36
Arterial stiffness during acute and recovery phases of children with rheumatic fever. ( 27130739 )
2016
37
Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever. ( 27499748 )
2016
38
Administering intramuscular penicillin injections to reduce rheumatic fever. ( 27281906 )
2016
39
Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever. ( 27774884 )
2016
40
A Review of Acute Rheumatic Fever and Rheumatic Heart Disease Research in Malaysia. ( 27801390 )
2016
41
An epidemiological study to assess the true incidence and prevalence of rheumatic heart disease and acute rheumatic fever in New Caledonian schoolchildren. ( 27203400 )
2016
42
Advanced heart block in acute rheumatic fever. ( 27053901 )
2016
43
Primary Prevention of Rheumatic Fever. ( 27351359 )
2016
44
Acute Rheumatic Fever with Erythema Marginatum. ( 28002702 )
2016
45
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
46
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
47
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever. ( 27465618 )
2016
48
Post-Streptococcal Autoimmune Sequelae: Rheumatic Fever and Beyond ( 26866235 )
2016
49
Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease. ( 27918954 )
2016
50
Estimating the risk of acute rheumatic fever in New Zealand by age, ethnicity and deprivation. ( 27311633 )
2016

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CD40LG FCN1 FCN2 FCN3 HLA-DRB1 HP
2
Show member pathways
12.64 CD40LG HLA-DRB1 IL2 TNF
3
Show member pathways
12.57 HLA-DRB1 IL2 TLR2 TNF
4
Show member pathways
12.48 CD40LG IL2 TLR2 TNF
5
Show member pathways
12.41 CD40LG HLA-DRB1 IL2 TNF
6
Show member pathways
12.38 HLA-DRB1 IL2 TLR2 TNF
7 12.32 CD40LG IL2 TLR2 TNF
8 12.01 HLA-DRB1 TLR2 TNF
9 11.93 HLA-DRB1 MBL2 TLR2
10
Show member pathways
11.89 CD40LG HLA-DRB1 TLR2 TNF
11
Show member pathways
11.72 IL2 TLR2 TNF
12
Show member pathways
11.68 FCN2 FCN3 MASP2 MBL2
13 11.63 HLA-DRB1 TLR2 TNF
14
Show member pathways
11.53 CD40LG IL2 TNF
15 11.45 CD40LG TLR2 TNF
16
Show member pathways
11.41 CD40LG IL2 TNF
17 11.33 HLA-DRB1 MASP2 MBL2
18 11.23 CD40LG TLR2 TNF
19
Show member pathways
11.18 FCN1 FCN2 FCN3 MASP2 MBL2
20 11.04 HLA-DRB1 IL2
21 11.01 CD40LG IL2 TNF
22 10.81 HLA-DRB1 IL2 TNF

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CD40LG HP IL2 MASP2 MBL2 TNF
2 extracellular region GO:0005576 9.61 CD40LG FCN1 FCN2 FCN3 HP IL2
3 cell surface GO:0009986 9.55 CD40LG HLA-DRB1 MBL2 TLR2 TNF
4 collagen trimer GO:0005581 8.92 FCN1 FCN2 FCN3 MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 FCN1 FCN2 FCN3 HP MASP2 MBL2
2 immune response GO:0006955 9.83 CD40LG HLA-DRB1 IL2 TLR2 TNF
3 innate immune response GO:0045087 9.8 FCN1 FCN2 FCN3 MASP2 MBL2 TLR2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.71 CD40LG TLR2 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.67 FCN2 MBL2 TLR2 TNF
6 positive regulation of phagocytosis GO:0050766 9.59 MBL2 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.58 TLR2 TNF
8 positive regulation of interleukin-12 production GO:0032735 9.58 CD40LG TLR2
9 positive regulation of interleukin-10 production GO:0032733 9.57 CD40LG TLR2
10 positive regulation of NF-kappaB import into nucleus GO:0042346 9.56 TLR2 TNF
11 immune system process GO:0002376 9.56 FCN1 FCN2 FCN3 HLA-DRB1 IL2 MASP2
12 positive regulation of chemokine production GO:0032722 9.55 TLR2 TNF
13 complement activation GO:0006956 9.55 FCN1 FCN2 FCN3 MASP2 MBL2
14 negative regulation of viral entry into host cell GO:0046597 9.52 FCN1 FCN3
15 negative regulation of growth of symbiont in host GO:0044130 9.51 MBL2 TNF
16 positive regulation of interleukin-8 secretion GO:2000484 9.49 FCN1 TLR2
17 opsonization GO:0008228 9.48 FCN2 MBL2
18 regulation of immunoglobulin secretion GO:0051023 9.46 CD40LG TNF
19 recognition of apoptotic cell GO:0043654 9.43 FCN1 FCN2 FCN3
20 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP2 MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.35 FCN1 FCN2 FCN3 IL2 MBL2
2 calcium-dependent protein binding GO:0048306 9.33 FCN2 MASP2 MBL2
3 signaling pattern recognition receptor activity GO:0008329 9.26 FCN1 TLR2
4 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 HP MASP2 MBL2

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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