MCID: RHM001
MIFTS: 55

Rheumatic Fever malady

Rare diseases, Cardiovascular diseases, Bone diseases categories

Aliases & Classifications for Rheumatic Fever

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Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 26ICD10 via Orphanet, 61UMLS via Orphanet, 34MESH via Orphanet, 25ICD10
See all sources

Rheumatic Fever, Aliases & Descriptions:

Name: Rheumatic Fever 9 41 11 43 47 60
Acute Rheumatic Fever 9 41 43 47
 
Inflammatory Rheumatism 41
Rhf - Rheumatic Fever 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

47
rheumatic fever:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult


External Ids:

Disease Ontology9 DOID:1586
ICD9CM27 390-392.99
MeSH33 D012213
NCIt38 C34984
Orphanet47 3099
ICD10 via Orphanet26 I01.2, I01.8, I01.9 I00, I01.0, I01.1, more
UMLS via Orphanet61 C0035436
MESH via Orphanet34 D012213
ICD1025 I00-I02

Summaries for Rheumatic Fever

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NIH Rare Diseases:41 Rheumatic fever is an inflammatory condition that may develop after infection with group a streptococcus bacteria, such as strep throat or scarlet fever. it is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. it is not clear why some people who are infected with group a streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. treatment usually includes antibiotics and/or anti-inflammatory medications. last updated: 1/11/2015

MalaCards based summary: Rheumatic Fever, also known as acute rheumatic fever, is related to rheumatic heart disease and systemic lupus erythematosus, and has symptoms including hypermelanotic macule, arthritis and nausea and vomiting. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Complement and coagulation cascades and Phagocytosis of Microbes. The drugs aspirin and choline salicylate and the compounds zymosan and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain.

Wikipedia:63 Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve... more...

Related Diseases for Rheumatic Fever

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Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Symptoms for Rheumatic Fever

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Symptoms:

 47 (show all 36)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • acute abdominal pain/colic
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • pallor
  • absent/hypotonic/flaccid abdominal wall muscles
  • constipation
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding

HPO human phenotypes related to Rheumatic Fever:

(show all 29)
id Description Frequency HPO Source Accession
1 hypermelanotic macule hallmark (90%) HP:0001034
2 arthritis hallmark (90%) HP:0001369
3 nausea and vomiting hallmark (90%) HP:0002017
4 anorexia hallmark (90%) HP:0002039
5 abnormality of temperature regulation hallmark (90%) HP:0004370
6 recurrent pharyngitis hallmark (90%) HP:0100776
7 sinusitis typical (50%) HP:0000246
8 pallor typical (50%) HP:0000980
9 abnormality of the mitral valve typical (50%) HP:0001633
10 abnormality of the myocardium typical (50%) HP:0001637
11 abnormality of the aortic valve typical (50%) HP:0001646
12 abdominal pain typical (50%) HP:0002027
13 chorea typical (50%) HP:0002072
14 arthralgia typical (50%) HP:0002829
15 abnormality of the endocardium typical (50%) HP:0004306
16 arrhythmia typical (50%) HP:0011675
17 chest pain typical (50%) HP:0100749
18 nephrotic syndrome occasional (7.5%) HP:0000100
19 epistaxis occasional (7.5%) HP:0000421
20 behavioral abnormality occasional (7.5%) HP:0000708
21 gait disturbance occasional (7.5%) HP:0001288
22 abnormality of the pericardium occasional (7.5%) HP:0001697
23 constipation occasional (7.5%) HP:0002019
24 migraine occasional (7.5%) HP:0002076
25 respiratory insufficiency occasional (7.5%) HP:0002093
26 abnormality of the pleura occasional (7.5%) HP:0002103
27 neurological speech impairment occasional (7.5%) HP:0002167
28 aplasia/hypoplasia of the abdominal wall musculature occasional (7.5%) HP:0010318
29 hemiballismus occasional (7.5%) HP:0100248

Drugs & Therapeutics for Rheumatic Fever

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Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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MalaCards organs/tissues related to Rheumatic Fever:

31
Heart, Skin, Brain, Tonsil, Bone, Lung, T cells, B cells, Testes, Neutrophil, Monocytes, Cardiac myocytes

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Articles related to Rheumatic Fever:

(show top 50)    (show all 582)
idTitleAuthorsYear
1
Controlling acute rheumatic fever and rheumatic heart disease in developing countries: are we getting closer? (25490689)
2015
2
Geoepidemiological hints about Streptococcus pyogenes strains in relationship with acute rheumatic fever. (25772310)
2015
3
Primary prevention of rheumatic fever in children: key factors to consider. (24897809)
2014
4
Clinically manifested myocarditis in acute rheumatic fever. (24676379)
2014
5
Accelerated junctional rhythm in children with acute rheumatic fever: is it specific to the disease? (23694767)
2013
6
Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971). (23610223)
2013
7
Adult-onset acute rheumatic fever. (23037480)
2012
8
Rheumatic Fever Follow-Up Study (RhFFUS) protocol: a cohort study investigating the significance of minor echocardiographic abnormalities in Aboriginal Australian and Torres Strait Islander children. (23186515)
2012
9
Rheumatic fever recurrence prevention: a nurse-led programme of 28-day penicillin in an area of high endemnicity. (21470327)
2011
10
Complete heart block complicating Acute Rheumatic Fever. (22085189)
2011
11
Persistence of acute rheumatic fever in a tertiary children's hospital. (21199062)
2011
12
Health-related quality of life of school- age children with rheumatic Fever. (21244818)
2010
13
Clinical presentation of rheumatic fever in an endemic area. (19880393)
2010
14
Underdiagnosis of acute rheumatic fever in primary care settings in a developing country. (19735369)
2009
15
Surgical repositioning of a traumatically intruded permanent incisor in a patient with rheumatic fever: case report. (19208001)
2009
16
School-based prevention of acute rheumatic fever: a group randomized trial in New Zealand. (19710585)
2009
17
Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever. (18400635)
2008
18
Rheumatic fever in a 2-year-old child. (17952489)
2008
19
What is the true frequency of carditis in acute rheumatic fever? A prospective clinical and Doppler blind study of 56 children with up to 60 months of follow-up evaluation. (18825449)
2008
20
Rheumatic fever and social justice. (17547542)
2007
21
Management of patients with rheumatic fever and rheumatic heart disease in Nigeria--need for a national system of primary, secondary and tertiary prevention. (16607438)
2006
22
Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)
2006
23
Obsessive-compulsive symptoms in adults with rheumatic fever. (16774666)
2006
24
Activity of lipid peroxidation processes and the condition of antioxidative defense system in children with rheumatic fever]. (16308440)
2005
25
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)
2005
26
Inverse relationship between the ratio of ICAM-1 expressing lymphocytes and serum TGF-beta 1 concentrations in acute rheumatic fever. (16023325)
2005
27
Is it possible to prevent rheumatic fever? (15751529)
2004
28
Rheumatic fever. (15522676)
2004
29
Acute rheumatic fever in children: recognition and treatment. (15612837)
2004
30
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review. (12768947)
2003
31
Serum cardiac troponin I in acute rheumatic fever. (12450620)
2002
32
Current issues in the prevention of rheumatic fever. (12410170)
2002
33
The potential for vaccine development against rheumatic fever. (11999099)
2002
34
Can we eradicate rheumatic fever in the 21st century? (11428492)
2001
35
Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. (11380924)
2001
36
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
37
Prophylactic efficiency of 3-weekly benzathine penicillin G in rheumatic fever. (10838716)
2000
38
The psychiatric symptoms of rheumatic fever. (11097972)
2000
39
Urticarial eruption associated with rheumatic fever in a child. (10469414)
1999
40
T. Duckett Jones and his criteria for the diagnosis of acute rheumatic fever. (9926367)
1999
41
Rheumatic fever chemoprophylaxis in adults. (12152837)
1998
42
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
43
Advanced atrioventricular block in a 39-year-old man with acute rheumatic fever. (9826853)
1998
44
Search for linkage disequilibrium between alleles in the T cell receptor alpha and beta chain loci and susceptibility to rheumatic fever. (7493775)
1995
45
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
46
Release of oxygen free radicals by macrophages and neutrophils in patients with rheumatic fever. (1915447)
1991
47
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
48
Rheumatic fever as a collagen disease. (13339200)
1956
49
Rheumatic fever as a collagen disease. (13229241)
1954
50
Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. (14780325)
1950

Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Compounds for genes affiliated with Rheumatic Fever

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Compounds related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 19)
idCompoundScoreTop Affiliating Genes
1zymosan4310.0MBL2, TLR2
2polymyxin b439.9MBL2, TLR2
3lipoteichoic acid439.9MBL2, TLR2
4anti-fungal439.9TLR2, MBL2
5peptidoglycan43 2810.9MBL2, TLR2
6latex439.8MBL2, TLR2
7n-acetylglucosamine439.7FCN2, MBL2
8agarose439.7MBL2, TLR2
9leukotriene b443 59 2411.6FCGR3B, TLR2
10sialic acid439.5MBL2, FCN2
11prednisolone43 28 1211.5FCGR3B, MBL2
12carbohydrates439.3MBL2, MASP2
13superoxide43 2410.3TLR2, FCGR3B, MBL2
14fibrinogen438.9TLR2, FCN2, MASP2, MBL2
15mannose438.9MBL2, MASP2, FCGR3B, TLR2
16mannan438.5MBL2, MASP2, FCN3, FCN2, TLR2
17polysaccharide438.4TLR2, FCGR3B, FCN2, FCN3, MBL2
18calcium43 49 24 1211.3TLR2, FCGR3B, FCN2, MASP2, MBL2
19serine437.1TLR2, FCGR3B, FCN2, FCN3, MASP2, MBL2

GO Terms for genes affiliated with Rheumatic Fever

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Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725629.5FCN3, FCN2
2collagenGO:00055819.0MBL2, FCN3, FCN2
3extracellular regionGO:00055767.7FCGR3B, FCN2, FCN3, MASP2, MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:00441309.6TLR2, MBL2
2opsonizationGO:00082289.6MBL2, FCN2
3complement activation, classical pathwayGO:00069589.6MBL2, MASP2
4defense response to Gram-positive bacteriumGO:00508309.4MBL2, TLR2
5complement activation, lectin pathwayGO:00018678.8MBL2, MASP2, FCN3, FCN2
6complement activationGO:00069568.7FCN2, FCN3, MASP2, MBL2
7innate immune responseGO:00450878.3TLR2, FCN2, FCN3, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:00302469.5FCN3, FCN2
2calcium-dependent protein bindingGO:00483068.8MBL2, MASP2, FCN2

Products for genes affiliated with Rheumatic Fever

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Sources for Rheumatic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet