Rheumatic Fever malady

Wikipedia: Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,...⁴⁴ more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to reactive arthritis and rheumatoid arthritis. An important gene associated with Rheumatic Fever is MYOM2 (myomesin (M-protein) 2, 165kDa), and among its related pathways are Bacterial infections in CF airways and NFAT Signaling and Lymphocyte Interactions. The drugs aspirin and aspirin pwdr [va product] and the compounds hyaluronic acid and polyethylene glycol have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin, and related mouse phenotypes are hematopoietic system and integument.

Aliases & Descriptions:

rheumatic fever 6 30 8 32 43 acute rheumatic fever 6 30 32 rheumatic fever without heart involvement (disorder) 6 rheumatic fever without mention of heart involvement 6 rheumatic fever without heart involvement 6 acute rheumatic arthritis (disorder) 6 acute rheumatic fever nos (disorder) 6

active rheumatic fever (disorder) 6 rheumatic fever (disorder) 6 acute rheumatic fever nos 6 rheumatic fever (& ) 6 rheumatic fever, active 6 inflammatory rheumatism 30 rhf - rheumatic fever 6

Diseases related to rheumatic fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 870)

id	Related Disease	Score	Top Affiliating Genes
1	reactive arthritis	29.3	CD79A, HP, CRP
2	rheumatoid arthritis	29.2	MBL2, HLA-DRB1, CRP
3	psoriatic arthritis	28.2	IL1B, IL6, TNF
4	arthritis	27.4	IL1A, IL1B, IL6, IL8, TNF
5	diabetic ketoacidosis	26.7	INS, IL6, ICAM1, ALB, HLA-DQB1, HLA-DRB1
6	systemic lupus erythematosus	24.8	CD79A, CD40LG, FCGR2A, FCGR3B, IL2, IL2RA
7	vasculitis	21.2	CD79A, CD40LG, INS, FCGR2A, FCGR3B, IL1B
8	purpura	20.4	CD79A, CD40LG, FCGR2A, IL1A, IL1B, IL2
9	cholesterol	19.1	PAEP, CD79A, CDKN2A, CD40LG, INS, FCGR2A
10	tuberculosis	18.8	CD79A, CD40LG, INS, FCGR2A, FCGR3B, IL1A
11	lupus erythematosus	18.6	CD79A, CD40LG, INS, FCGR2A, FCGR3B, FCN3
12	neisseria meningitidis infection	13.7	FCGR2A, MBL2, TLR2
13	congenital toxoplasmosis	13.6	CD79A, CD40LG
14	celiac disease	13.6	HLA-DQA1, HLA-DQB1
15	glucosephosphate dehydrogenase deficiency	13.6	HP, G6PD, PGD
16	favism	13.6	CAT, HP, G6PD
17	paroxysmal nocturnal hemoglobinuria	13.5	FCGR3B, HP, G6PD
18	tubulointerstitial nephritis and uveitis	13.5	HLA-DQA1, HLA-DQB1, HLA-DRB1
19	impetigo	13.5	CD79A, CD40LG, SKA1, SKA2
20	cryptosporidiosis	13.5	CD40LG, IL1A, MBL2, CAT
21	cervical dystonia	13.5	HLA-DQA1, HLA-DQB1, HLA-DRB1
22	leprosy	13.5	HLA-DQA1, HLA-DQB1, HLA-DRB1, TLR2
23	bacteremia, protection against	13.4	MBL2, CAT, CRP
24	avascular necrosis of femoral head	13.4	CAT, HLA-DRB1, SOD1
25	diabetic cataract	13.4	CAT, G6PD, SOD1
26	berger disease	13.4	CD79A, CD40LG, MBL2, ACE
27	autoimmune thrombocytopenic purpura	13.4	CD79A, CD40LG, IL2RA
28	lipoid nephrosis	13.4	CD79A, ALB, ADM
29	hypertensive nephropathy	13.4	ALB, ACE
30	isolated growth hormone deficiency	13.4	CD79A, CD40LG, POMC
31	immunoglobulin alpha deficiency	13.4	CD79A, CD40LG, MBL2, HP, HLA-DQB1
32	cryofibrinogenemia	13.4	CD79A, CD40LG
33	methemoglobinemia	13.4	HP, G6PD, SOD1
34	mesangial proliferative glomerulonephritis	13.4	CD79A, IL6, MBL2
35	hematologic cancer	13.3	IL2, IL2RA, MBL2
36	ectopic pregnancy	13.3	PAEP, CD79A, CD40LG, IL2RA, TLR2
37	immune-complex glomerulonephritis	13.3	CD40LG, ICAM1, ALB
38	cardiac tamponade	13.3	CD79A, CD40LG, CRP
39	infective endocarditis	13.3	FCGR2A, MBL2, CRP
40	meningitis and encephalitis	13.3	CAT, CRP, SOD1
41	autoimmune hepatitis	13.3	CD40LG, HLA-DQB1, HLA-DRB1, KRT8
42	hyperphenylalaninemia	13.3	CAT, G6PD, SOD1
43	parotitis	13.3	CD79A, CRP, G6PD
44	bilirubin metabolic disorder	13.3	ALB, HP, G6PD
45	heparin-induced thrombocytopenia	13.3	CD79A, CD40LG, FCGR2A, ALB
46	agammaglobulinemia	13.3	CD79A, CD40LG, IL2
47	membranous glomerulonephritis	13.3	CD79A, ALB, HP
48	severe congenital neutropenia	13.3	FCGR2A, FCGR3B, CAT, HLA-DQB1, HLA-DRB1
49	multiple sclerosis	13.3	HLA-DQB1, HLA-DRB1
50	intrahepatic cholestasis of pregnancy	13.3	IL2RA, HLA-DQA1, HLA-DQB1, HLA-DRB1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 acetylsalicylate sodium, aspirin, aspirin pwdr [va product], choline salicylate, penicillin g benzathine

MalaCards organs/tissues related to rheumatic fever:

²²

MGI Mouse Phenotypes related to rheumatic fever:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.3	KRT8, HLA-DQB1, HLA-DQA1
2	integument phenotype	MP:0010771	9.8	ADCY1, POMC, TLR2, GNAS, MNT
3	renal/urinary system phenotype	MP:0005367	9.8	ADM, GNAS, INS
4	endocrine/exocrine gland phenotype	MP:0005379	9.7	CD40LG, MNT, IL2, GNAS, TLR2
5	digestive/alimentary phenotype	MP:0005381	9.0	TGFB1, TLR2, KRT8, INS, MNT, CDKN2A
6	liver/biliary system phenotype	MP:0005370	9.0	ADM, SOD1, TLR2, IL6, IL2, INS
7	skeleton phenotype	MP:0005390	8.7	GNAS, IL6, INS, MNT, CDKN2A
8	nervous system phenotype	MP:0003631	8.6	ADCY1, POMC, TGFB1, TLR2, G6PD, EGR3
9	immune system phenotype	MP:0005387	8.3	CD79A, ADM, POMC, KRT8, TNF, HLA-DQB1
10	adipose tissue phenotype	MP:0005375	8.1	TGFB1, TLR2, ACE, TNF, GNAS, IL6
11	mortality/aging	MP:0010768	7.5	HLA-DQB1, KRT8, EGR3, ACE, G6PD, TLR2
12	muscle phenotype	MP:0005369	7.4	ADM, SOD1, TGFB1, TLR2, EGR3, TNF
13	tumorigenesis	MP:0002006	6.7	HP, TNF, ACE, TLR2, TGFB1, POMC
14	behavior/neurological phenotype	MP:0005386	6.3	ACE, TLR2, TGFB1, SOD1, POMC, ADCY1
15	homeostasis/metabolism phenotype	MP:0005376	5.5	HP, HLA-DQB1, CRP, G6PD, TLR2, TGFB1
16	cellular phenotype	MP:0005384	5.3	HP, HLA-DQB1, TNF, ACE, G6PD, TLR2
17	cardiovascular system phenotype	MP:0005385	4.9	CRP, KRT8, ACE, G6PD, TLR2, TGFB1

Articles related to rheumatic fever:

(show all 29)

id	Title	Authors	Year	Affiliating Genes
1	Ficolin 2 (FCN2) functional polymorphisms and the ris k of rheumatic fever and rheumatic heart disease. (19664148)	Messias-Reason I.J.... Kun J.F.	2009	FCN2, FCN3, FCN1
2	High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever. (18602696)	Schafranski M.D.... de Messias-Reason I.J.	2008	MBL2
3	Functional MASP2 gene polymorphism in patients with history of rheumatic fever. (18295674)	Schafranski M.D.... de Messias-Reason I.J.	2008	MASP2
4	Glucocorticoid-induced diabetic ketoacidosis in acute rheumatic fever. (19087951)	CaA9daA9 D.N.... Cakal E.	2008	INS
5	Association of polymorphisms within the promoter region of the tumor necrosis factor-alpha with clinical outcomes of rheumatic fever. (17079017)	Ramasawmy R.... Guilherme L.	2007	TNF
6	Cardiac manifestations of Henoch-Schoenlein purpura: IgA mediated vasculitis or Rheumatic fever? (17047991)	Shin J.I.... Sul J.H.	2007	CD79A
7	Progress in M-protein-based subunit vaccines to prevent rheumatic fever and rheumatic heart disease. (17330399)	Olive C.	2007	MYOM2
8	HLA class II DR and DQ genotypes and haplotypes associated with rheumatic fever among a clinically homogeneous patient population of Latvian children. (17559688)	Stanevicha V.... Gardovska D.	2007	HLA-DQA1, HLA-DQB1, HLA-DRB1
9	Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States. (16421785)	Shulman S.T.... Tanz R.R.	2006	MYOM2
10	Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)	Berdeli A.... Aydin H.H.	2006	TNF
11	Inverse relationship between the ratio of ICAM-1 expressing lymphocytes and serum TGF-beta 1 concentrations in acute rheumatic fever. (16023325)	Aksu G.... Kutukculer N.	2005	ICAM1, TGFB1
12	DRB1, DQA1, DQB1 genes in Turkish children with rheumatic fever. (15789899)	Hallioglu O.... Ozer S.	2005	HLA-DQA1, HLA-DQB1, HLA-DRB1
13	Adrenomedullin and total nitrite levels in children with acute rheumatic fever. (15885231)	Balat A.... CoA9kun Y.	2005	ADM
14	TNF-alpha G-308A polymorphism is associated with rheumatic fever and correlates with increased TNF-alpha production. (16046099)	Sallakci N.... Yegin O.	2005	TNF
15	Activity of lipid peroxidation processes and the condition of antioxidative defense system in children with rheumatic fever (16308440)	Shanidze E.... Zhvania M.	2005	CAT
16	TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)	Berdeli A.... Aydin H.H.	2005	TLR2
17	Involvement of immunoglobulin FcgammaRIIA and FcgammaRIIIB gene polymorphisms in susceptibility to rheumatic fever. (15369725)	Berdeli A.... Aydin H.H.	2004	FCGR2A, FCGR3B
18	Lack of association between the HLA-DRB1 locus and post-streptococcal reactive arthritis and acute rheumatic fever in Italian children. (15505772)	Simonini G.... Falcini F.	2004	HLA-DRB1
19	Angiotensin-converting enzyme genotype predicts valve damage in acute rheumatic fever. (12578328)	Atalar E.... Tuncbilek E.	2003	ACE
20	Acute rheumatic fever with three major criteria: polyarthritis, carditis and chorea. A case report. (10028869)	GA1nal N.... Atasay B.	1998	CRP
21	Cytokines in acute rheumatic fever. (9007485)	YeA9in O.... ErtuA9 H.	1997	IL6, IL1B, IL8
22	Search for linkage disequilibrium between alleles in the T cell receptor alpha and beta chain loci and susceptibility to rheumatic fever. (7493775)	Abbott W.G.... Tan P.L.	1995	TRA@
23	Haptoglobin in rheumatic fever. (8935147)	Anil K.... Gupta P.K.	1995	HP
24	Serum-soluble receptors for tumor necrosis factor-alpha and interleukin-2, and neopterin in acute rheumatic fever. (7994924)	Samsonov M.Y.... Fuchs D.	1995	TNF, IL2RA, IL2
25	Identification of cardiac autoantigens in human heart cDNA libraries using acute rheumatic fever sera. (8037842)	Eichbaum Q.G.... Parker M.I.	1994	GNAS, KRT8, ADCY1
26	Action of oxygen free radical scavengers and inhibito rs on the chemiluminescence response of monocytes and neutrophils in rheumatic fever. (8400025)	Kumar V.... Ganguly N.K.	1993	SOD1, CAT
27	Serum cholesterol levels in patients with acute rheumatic fever. (8322742)	Panamonta M.... Chaikitpinyo A.	1993	ALB
28	Release of oxygen free radicals by macrophages and neutrophils in patients with rheumatic fever. (1915447)	Kumar V.... Wahi P.L.	1991	PGD, G6PD
29	Antibodies to N-acetylglucosamine and heparin in acut e and remission phases of rheumatic fever. (1668760)	Shastry P.... Kinare S.G.	1991	CD40LG

Genes related to rheumatic fever according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	MYOM2	myomesin (M-protein) 2, 165kDa	11.0	Publications
2	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
3	TLR2	toll-like receptor 2	11.0	Publications
4	AKAP17A	A kinase (PRKA) anchor protein 17A	11.0
5	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	11.0	Publications
6	FCN1	ficolin (collagen/fibrinogen domain containing) 1	11.0	Publications
7	OR13C4	olfactory receptor, family 13, subfamily C, member 4	11.0	Disorders
8	MNT	MAX binding protein	11.0
9	RAD23A	RAD23 homolog A (S. cerevisiae)	11.0	Publications
10	FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	11.0	Publications
11	EGR3	early growth response 3	11.0
12	SKA2	spindle and kinetochore associated complex subunit 2	11.0
13	SKA3	spindle and kinetochore associated complex subunit 3	11.0
14	SKA1	spindle and kinetochore associated complex subunit 1	11.0
15	MASP2	mannan-binding lectin serine peptidase 2	11.0	Publications
16	FCGR3B	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	11.0	Publications
17	PGD	phosphogluconate dehydrogenase	11.0	Publications
18	PAEP	progestagen-associated endometrial protein	11.0
19	KRT8	keratin 8	11.0	Publications
20	ADM	adrenomedullin	11.0	Publications
21	ADCY1	adenylate cyclase 1 (brain)	11.0	Publications
22	FCGR2A	Fc fragment of IgG, low affinity IIa, receptor (CD32)	11.0	Publications
23	HLA-DQA1	major histocompatibility complex, class II, DQ alpha 1	11.0	Publications
24	HP	haptoglobin	11.0	Publications
25	CAT	catalase	11.0	Publications
26	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
27	IL1A	interleukin 1, alpha	11.0	Publications
28	CD79A	CD79a molecule, immunoglobulin-associated alpha	11.0	Publications
29	HLA-DQB1	major histocompatibility complex, class II, DQ beta 1	11.0	Publications
30	GNAS	GNAS complex locus	11.0	Publications
31	G6PD	glucose-6-phosphate dehydrogenase	11.0	Publications
32	CD40LG	CD40 ligand	11.0	Publications
33	TRA@	T cell receptor alpha locus	11.0	Publications
34	SOD1	superoxide dismutase 1, soluble	11.0	Publications
35	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Publications
36	POMC	proopiomelanocortin	11.0
37	ICAM1	intercellular adhesion molecule 1	11.0	Publications
38	TGFB1	transforming growth factor, beta 1	11.0	Publications
39	ALB	albumin	11.0	Publications
40	TNF	tumor necrosis factor	11.0	Publications
41	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
42	IL2	interleukin 2	11.0	Publications
43	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
44	IL8	interleukin 8	11.0	Publications
45	INS	insulin	11.0	Publications
46	IL1B	interleukin 1, beta	11.0	Publications
47	CRP	C-reactive protein, pentraxin-related	11.0	Publications
48	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0

Pathways related to rheumatic fever according to GeneDecks:

(show top 50)    (show all 95)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.7	TLR2
2	NFAT Signaling and Lymphocyte Interactions36	10.2	IL2, IL1A
3	Graft-versus-host disease20	10.2	HLA-DQA1, IL2, IL1A
4	Immune System38	10.1	ICAM1, CD79A
5	Phagosome20	9.8	HLA-DRB1, HLA-DQB1, TLR2, FCGR2A, FCGR3B, MBL2
6	Asthma20	9.8	HLA-DRB1, TNF, CD40LG, HLA-DQA1, HLA-DQB1
7	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	IL2, IL2RA, TNF, TGFB1
8	Autoimmune thyroid disease20	9.7	HLA-DQA1, HLA-DQB1, IL2, HLA-DRB1, CD40LG
9	Staphylococcus aureus infection20	9.6	ICAM1, HLA-DRB1, HLA-DQB1, HLA-DQA1, MASP2, MBL2
10	Immune response IL-22 signaling pathway10	9.5	HLA-DQB1, IL2, IL2RA, HLA-DQA1, HLA-DRB1, TRA@
11	Viral myocarditis20	9.5	ICAM1, CD40LG, HLA-DRB1, HLA-DQB1, HLA-DQA1
12	Immune response_IL-22 signaling pathway41	9.5	HLA-DRB1, TRA@, HLA-DQB1, HLA-DQA1, IL2RA, IL2
13	Systemic lupus erythematosus20	9.5	CD40LG, TNF, HLA-DQA1, HLA-DRB1, FCGR3B, HLA-DQB1
14	THC Differentiation Pathway36	9.5	HLA-DQB1, HLA-DQA1, IL2RA, HLA-DRB1, TNF, IL2
15	Allograft rejection20	9.4	HLA-DQA1, TNF, CD40LG, IL2, HLA-DRB1, HLA-DQB1
16	Toxoplasmosis20	9.4	TGFB1, TLR2, TNF, HLA-DQB1, HLA-DQA1, CD40LG
17	PGC1Alpha Pathway36	9.2	IL1A, IL1B, IL2, IL8
18	NFAT in Immune Response36	9.2	CD79A, TGFB1, FCGR2A, FCGR3B, IL2, HLA-DQA1
19	Tec Kinases Signaling36	9.1	IL6, TGFB1, TLR2, IL8, IL2, IL2RA
20	Immune response_MIF-mediated glucocorticoid regulation41	9.1	IL8, ICAM1, IL6, IL2, TNF
21	Intestinal immune network for IgA production20	9.1	IL2, CD40LG, TGFB1, HLA-DRB1, HLA-DQB1, HLA-DQA1
22	Immune response MIF-mediated glucocorticoid regulation10	9.1	TNF, ICAM1, IL8, IL6, IL2
23	Osteoclast differentiation20	9.0	TGFB1, TNF, IL1B, IL1A, FCGR3B, FCGR2A
24	Hematopoietic cell lineage20	8.9	HLA-DRB1, TNF, IL1A, IL1B, IL2RA, IL6
25	Measles20	8.8	IL1B, IL2, IL2RA, IL6, IL1A, TLR2
26	Immune response IL-1 signaling pathway10	8.8	IL8, IL6, IL1B, IL1A, TNF
27	Immune response_IL-1 signaling pathway41	8.8	IL1A, TNF, IL8, IL6, IL1B
28	Chagas disease (American trypanosomiasis)20	8.7	GNAS, TGFB1, TLR2, ACE, TNF, IL6
29	Selected targets of GCR-alpha10	8.6	INS, TLR2, IL8, IL1B, IL6
30	Leishmaniasis20	8.6	IL1A, FCGR3B, HLA-DQA1, FCGR2A, HLA-DQB1, HLA-DRB1
31	NF-KappaB (p50-p65) Pathway36	8.5	TLR2, IL1A, TGFB1, TNF, IL6, IL1B
32	Cytokine Network36	8.5	IL1A, IL2, IL6, IL8, IL1B, TNF
33	NF-KappaB Family Pathway36	8.5	TNF, TLR2, TGFB1, IL6, IL2, IL1B
34	Pertussis20	8.5	IL1B, IL1A, IL6, IL8, TNF
35	MIF Mediated Glucocorticoid Regulation36	8.4	TNF, IL8, IL6, IL2, IL1B, IL1A
36	Amoebiasis20	8.4	TNF, GNAS, IL8, ADCY1, IL6, TLR2
37	MIF Regulation of Innate Immune Cells36	8.4	IL1B, IL1A, IL2, IL6, IL8, TNF
38	Type I diabetes mellitus20	8.3	TNF, HLA-DQA1, INS, IL1A, HLA-DRB1, IL2
39	Glucocorticoid Receptor Signaling36	8.3	IL8, IL6, IL2RA, IL1B, IL2, TGFB1
40	Malaria20	8.3	ICAM1, IL8, IL6, TNF, IL1B, TGFB1
41	Tuberculosis20	8.2	TNF, TGFB1, HLA-DQB1, TLR2, HLA-DRB1, HLA-DQA1
42	STAT3 Pathway36	8.2	IL1A, IL8, IL2RA, IL2, IL6, TNF
43	Influenza A20	8.1	IL6, TNF, HLA-DRB1, HLA-DQB1, HLA-DQA1, ICAM1
44	all-trans-Retinoic Acid Signaling in Brain36	8.0	IL2, TNF, IL8, IL6, IL1B, IL1A
45	PAK Pathway36	7.9	TNF, IL1A, IL1B, IL2, IL2RA, IL6
46	SOCS Pathway36	7.9	IL2, IL1A, IL6, IL1B, INS, IL8
47	Cytokine-cytokine receptor interaction20	7.9	CD40LG, IL1A, IL2, IL2RA, IL6, IL8
48	PEDF Induced Signaling36	7.8	IL8, IL1A, IL1B, TNF, IL2, IL6
49	MAPK Family Pathway36	7.8	IL1B, IL2, IL1A, TGFB1, IL2RA, TNF
50	Rheumatoid arthritis20	7.7	IL6, HLA-DRB1, IL1A, IL1B, ICAM1, IL8

Compounds related to rheumatic fever according to GeneDecks:

(show top 50)    (show all 268)

id	Compound	Score	Top Affiliating Genes
1	hyaluronic acid32 18	11.8	MYOM2
2	polyethylene glycol32	10.4	HP, G6PD
3	ivig32	10.1	CRP
4	n acetylcysteine32	10.0	IL2RA, CDKN2A, CD79A
5	mannan32	10.0	MASP2, FCN3, FCN2, CD40LG, MBL2, CD79A
6	pge232	9.9	IL1A, ADM, ADCY1, TLR2, HP, GNAS
7	ascorbic acid32 18	10.7	IL2RA, POMC, CD40LG, G6PD, IL1A, PGD
8	endotoxin32	9.7	CRP, ADM, HP
9	h2o232	9.3	CD79A, ADM, PGD, POMC, HP, ICAM1
10	epinephrine32 9 18 9	12.2	IL1A, FCGR2A, ADCY1, INS, HP, CD79A
11	polyinosinic-polycytidylic acid32	9.2	TLR2, IL6, IL2, IL8
12	daclizumab32 9 9	11.1	FCGR2A, IL2, FCGR3B, INS, CD40LG, IL2RA
13	testosterone32 9 18 9	12.0	CD40LG, CDKN2A, KRT8, PAEP, CD79A, IL1A
14	histamine32 18	9.9	CD40LG, CD79A, FCGR2A, ADM, ADCY1, TLR2
15	rituximab32 34 9 9	11.9	CRP, CD40LG, CD79A, IL2RA, FCGR3B, IL2
16	ulinastatin32	8.8	IL6, ICAM1, HP, TNF, IL8, SOD1
17	rantes32	8.7	IL1A, CD40LG, MBL2, IL2, IL2RA, IL6
18	polysaccharide32	8.7	CD79A, FCN2, CD40LG, IL2RA, FCN3, FCGR2A
19	bucillamine32	8.6	IL1B, IL6, CAT, CD79A, CRP
20	malondialdehyde32	8.5	HP, IL2RA, CAT, CRP, SOD1, G6PD
21	gold sodium thiomalate32	8.5	IL1A, IL1B, IL2RA, IL8, HLA-DRB1, TNF
22	polymyxin b32	8.5	TNF, IL6, ICAM1, MBL2, IL8, IL1A
23	cyclosporin a32 42	9.4	TGFB1, IL8, IL2RA, HP, EGR3, TLR2
24	sulfasalazine32 9 9	10.4	CD79A, CRP, TNF, IL2RA, IL1B, CD40LG
25	diphenyleneiodonium32	8.2	TNF, IL1B, IL8, ICAM1, SOD1, TGFB1
26	okt332	8.1	TNF, CD79A, IL2RA, CD40LG, IL2, ICAM1
27	il 1032	8.0	IL1B, IL2, IL2RA, IL6, IL8, TNF
28	gm-csf32	7.9	IL6, IL2, IL1B, IL1A, IL8, ICAM1
29	ramipril32 9 9	9.9	CD79A, INS, ALB, TGFB1, ACE, CRP
30	pentoxifylline32 9 9	9.9	ICAM1, IL6, IL2RA, IL2, TNF, IL1B
31	pdtc32	7.9	IL1A, IL1B, IL6, ICAM1, CAT, TGFB1
32	prednisolone32 9 9	9.7	TNF, ALB, IL6, IL2RA, CRP, POMC
33	vegf32	7.7	POMC, TGFB1, KRT8, CRP, HP, ICAM1
34	8-isoprostane32	7.6	CAT, HP, TNF, CRP, SOD1, IL6
35	prostacyclin32	7.4	ICAM1, IL1B, FCGR2A, TNF, ACE, SOD1
36	etanercept32 9 9	9.3	CRP, TNF, IL8, IL1B, FCGR3B, FCGR2A
37	hydrocortisone32 9 9	9.2	ADM, POMC, TNF, IL8, IL6, IL2
38	fibrinogen32	7.2	ICAM1, MBL2, IL6, FCN2, FCN1, INS
39	creatinine32	7.1	MBL2, CDKN2A, CD40LG, IL1A, IL2RA, HP
40	indomethacin32 9 9	9.1	CAT, TNF, TGFB1, SOD1, POMC, ADM
41	genistein32 9 18 9	9.8	CDKN2A, CD40LG, FCGR3B, IL1A, IL1B, IL2
42	methotrexate32 34 42 9 9	10.8	TNF, CD79A, IL6, IL2RA, CDKN2A, PGD
43	neopterin32	6.7	IL2RA, CD79A, CD40LG, IL1A, IL1B, IL2
44	nitric oxide32 9 18 9	9.4	IL8, MBL2, CAT, HP, TNF, ACE
45	actinomycin d32	6.3	ADM, IL1A, FCGR2A, CD40LG, CDKN2A, IL1B
46	serine32	6.1	IL2, KRT8, CD40LG, FCN1, CDKN2A, GNAS
47	lactate32	6.0	ADM, PGD, SOD1, TGFB1, G6PD, KRT8
48	alanine32	5.9	GNAS, HP, CRP, TLR2, TGFB1, HLA-DRB1
49	cycloheximide32	5.8	POMC, CDKN2A, TNF, ADM, TGFB1, TLR2
50	dexamethasone32 42 34 9 9	9.7	ICAM1, ADM, TGFB1, TLR2, TNF, HP

Cellular components related to rheumatic fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	condensed chromosome outer kinetochore	GO:000940	10.2	SKA1, SKA2, SKA3
2	clathrin-coated endocytic vesicle membrane	GO:030669	9.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
3	collagen	GO:005581	9.8	FCN1, FCN2, FCN3, MBL2
4	MHC class II protein complex	GO:042613	9.8	HLA-DRB1, HLA-DQB1, HLA-DQA1
5	trans-Golgi network membrane	GO:032588	9.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, GNAS
6	external side of plasma membrane	GO:009897	8.9	TLR2, ACE, TNF, HLA-DRB1, ICAM1, CD40LG
7	extracellular region	GO:005576	5.2	ALB, GNAS, HP, CRP, TGFB1, SOD1
8	extracellular space	GO:005615	4.4	CD40LG, ALB, HP, TNF, CRP, ACE

Biological processes related to rheumatic fever according to GeneDecks:

(show all 41)

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of microtubule polymerization or depolymerization	GO:031110	10.5	SKA1, SKA2, SKA3
2	complement activation, lectin pathway	GO:001867	10.5	MASP2, MBL2, FCN3, FCN2
3	pentose biosynthetic process	GO:019322	10.4	PGD, G6PD
4	cAMP biosynthetic process	GO:006171	10.4	GNAS, ADCY1, ADM
5	negative regulation of growth of symbiont in host	GO:044130	10.3	TLR2, TNF, MBL2
6	pentose-phosphate shunt, oxidative branch	GO:009051	10.2	PGD, G6PD
7	mononuclear cell proliferation	GO:032943	10.1	TGFB1, ACE
8	response to copper ion	GO:046688	10.1	SOD1, ICAM1, IL1A
9	positive regulation of chemokine production	GO:032722	10.0	TLR2, TNF, IL6
10	defense response to Gram-positive bacterium	GO:050830	10.0	TLR2, TNF, MBL2, IL6
11	interferon-gamma-mediated signaling pathway	GO:060333	9.9	ICAM1, HLA-DQA1, HLA-DQB1, HLA-DRB1
12	opsonization	GO:008228	9.8	CRP, MBL2, FCN2, FCN1
13	positive regulation of cytokine secretion	GO:050715	9.8	TLR2, TNF, IL1A, INS
14	chronic inflammatory response to antigenic stimulus	GO:002439	9.8	IL1B
15	positive regulation of NF-kappaB import into nucleus	GO:042346	9.7	TLR2, TNF, IL1B
16	positive regulation vascular endothelial growth factor production	GO:010575	9.7	IL1A, IL1B, TGFB1
17	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.6	TNF, IL1B
18	sequestering of triglyceride	GO:030730	9.6	TNF, IL1B
19	positive regulation of cell division	GO:051781	9.6	TGFB1, CAT, IL1B, IL1A
20	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	TGFB1, TLR2, TNF, IL1B
21	fever generation	GO:001660	9.4	IL1B, IL1A
22	negative regulation of lipid catabolic process	GO:050995	9.3	INS, IL1B, TNF
23	positive regulation of interferon-gamma production	GO:032729	9.3	CD40LG, IL1B, IL2, TNF
24	negative regulation of lipid storage	GO:010888	9.3	IL6, TNF, CRP
25	positive regulation of interleukin-6 production	GO:032755	9.3	TLR2, TNF, IL6, IL1B, IL1A
26	positive regulation of mitosis	GO:045840	9.2	TNF, IL1B, IL1A, INS
27	positive regulation of nitric oxide biosynthetic process	GO:045429	9.1	TLR2, TNF, ICAM1, IL1B, INS
28	regulation of insulin secretion	GO:050796	9.0	TNF, GNAS, IL1B, INS
29	acute-phase response	GO:006953	9.0	CRP, MBL2, IL6, INS
30	response to glucocorticoid stimulus	GO:051384	9.0	IL1B, IL6, TNF, ADM
31	MAPK cascade	GO:000165	9.0	TGFB1, TNF, IL1B, INS
32	immune response	GO:006955	8.9	TLR2, HLA-DRB1, HLA-DQB1, HLA-DQA1, IL8, IL2RA
33	anti-apoptosis	GO:006916	8.9	SOD1, TNF, IL2, IL1B, IL1A, CD40LG
34	negative regulation of apoptotic process	GO:043066	8.8	EGR3, TNF, CAT, ALB, IL6, INS
35	cytokine-mediated signaling pathway	GO:019221	8.8	HLA-DRB1, HLA-DQB1, HLA-DQA1, ICAM1, IL6, IL1B
36	signal transduction	GO:007165	8.6	ADM, ADCY1, POMC, TLR2, AKAP17A, IL8
37	response to hypoxia	GO:001666	8.4	ADM, TGFB1, CRP, TNF, CAT, IL1B
38	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.2	INS, TGFB1, TLR2, TNF, CAT, ICAM1
39	negative regulation of cell proliferation	GO:008285	7.9	ADM, TGFB1, TNF, IL8, IL6, IL1B
40	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.8	POMC, TGFB1, TLR2, TNF, IL6, IL2
41	inflammatory response	GO:006954	7.5	TGFB1, TLR2, CRP, TNF, IL8, IL6

Molecular functions related to rheumatic fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	MHC class II receptor activity	GO:032395	9.9	HLA-DQA1, HLA-DQB1, HLA-DRB1
2	receptor binding	GO:005102	9.3	ADM, POMC, CAT, MBL2, FCN3, FCN2
3	cytokine activity	GO:005125	8.3	CD40LG, IL1A, IL1B, IL2, IL6, TNF