MCID: RHM001
MIFTS: 65

Rheumatic Fever malady

Cardiovascular diseases, Bone diseases categories

Summaries for Rheumatic Fever

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to arthritis and glomerulonephritis, and has symptoms including pallor, facial pain/cephalalgia/migraine and anorexia. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Phagocytosis of Microbes and Immune response Lectin induced complement pathway. The drugs aspirin and choline salicylate and the compounds Palivizumab and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin.

Description from OMIM:46 268240

Aliases & Classifications for Rheumatic Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


Aliases & Descriptions:

rheumatic fever 8 42 10 44 48 46 60
acute rheumatic fever 8 42 44 48
rheumatic fever without mention of heart involvement 8
rheumatic fever without heart involvement 8
acute rheumatic arthritis 8
acute rheumatic fever nos 8
rheumatic fever, active 8
inflammatory rheumatism 42
active rheumatic fever 8
rhf - rheumatic fever 8


External Ids:

Disease Ontology8 DOID:1586
NCIt39 C34984
ICD9CM27 390-392.99
MeSH34 D012213
SNOMED-CT via Orphanet57 58718002
ICD10 via Orphanet26 I01.0, I00, I01.1 I01.2, I01.8, I01.9, more
UMLS via Orphanet61 C0035436
OMIM46 268240
MESH via Orphanet35 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TLR2, FCGR3B, FCGR2A
2glomerulonephritis30.7MBL2, FCGR2A
3kawasaki disease30.7ADM, MBL2
4acute poststreptococcal glomerulonephritis30.6SKA3, SKA2, SKA1
5systemic lupus erythematosus30.3FCGR3B, FCGR2A
6rheumatoid arthritis30.2TLR2, MBL2, FCGR3B, FCGR2A
7leukemia30.0FCGR3B, MBL2, TLR2
8endocarditis10.6
9reactive arthritis10.5
10scarlet fever10.5
11pharyngitis10.5
12rheumatic myocarditis10.5
13subacute bacterial endocarditis10.4
14obsessive-compulsive disorder10.3
15chorea minor10.3
16atrioventricular block10.3
17antiphospholipid syndrome10.3
18pulmonary edema10.3
19infective endocarditis10.3
20collagen disease10.2
21lupus erythematosus10.2
22pericarditis10.2
23purpura10.2
24sydenham's chorea10.2
25chronic rheumatic pericarditis10.2
26septic arthritis10.2
27rheumatic congestive heart failure10.2
28acute orbital inflammation10.2
29aortic valve stenosis10.2
30pyoderma10.2
31coronary artery disease10.1
32connective tissue disease10.1
33branch retinal artery occlusion10.0
34cardiac tamponade10.0
35decubitus ulcer10.0
36mitral valve prolapse10.0
37congenital heart block10.0
38hemoglobin c disease10.0
39iritis10.0
40familial mediterranean fever10.0
41nodular nonsuppurative panniculitis10.0
42mitral valve stenosis10.0
43diabetic ketoacidosis10.0
44osteonecrosis10.0
45subacute leukemia10.0
46erysipelas10.0
47henoch-schoenlein purpura10.0
48noonan syndrome10.0
49aseptic meningitis10.0
50rapidly progressive glomerulonephritis10.0

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Clinical Features for Rheumatic Fever

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

268240

Clinical synopsis from OMIM:

268240

Symptoms:

48 (show all 36)
  • pallor
  • facial pain/cephalalgia/migraine
  • anorexia
  • nephrotic syndrome
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • endocardium anomalies/fibroelastosis/endocarditis
  • pharyngitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • hemiballism/unilateral movement disorders
  • alexia/agraphia/writing/reading troubles
  • epistaxis/nose bleeding
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myocardium anomalies/myocarditis
  • asthenia/fatigue/weakness
  • absent/hypotonic/flaccid abdominal wall muscles
  • arthritis/synovitis/synovial proliferation
  • psychic/behavioural troubles
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • abnormal gait
  • constipation
  • myoclonus/fasciculations
  • fever/chilling
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • thoracic/chest pain
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • cardiac valvulopathy
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • macules
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Rheumatic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rheumatic Fever

Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Search CenterWatch for Rheumatic Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rheumatic Fever:

32
Heart, Brain, Skin, Bone, B cells, T cells, Lung, Testes, Tonsil, Cardiac myocytes, Monocytes

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Sources:
50PubMed
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Articles related to Rheumatic Fever:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
Poststreptococcal glomerulonephritis and rheumatic fever: two faces of the same coin. (23661531)
2013
2
Determinants of poor adherence to secondary antibiotic prophylaxis for rheumatic fever recurrence on Lifou, New Caledonia: a retrospective cohort study. (23402561)
2013
3
Acute rheumatic fever in the Central Anatolia Region of Turkey: a 30-year experience in a single center. (21866339)
2012
4
Rheumatic fever presentation and outcome: a case-series report. (22460413)
2012
5
Trends in rheumatic fever: clinical aspects and perspectives in prophylactic treatments. (22724579)
2012
6
Global research priorities in rheumatic fever and rheumatic heart disease. (21677798)
2011
7
The role of viral agents in aetiopathogenesis of acute rheumatic fever. (20401762)
2011
8
A dramatic decline in university hospital admissions of acute rheumatic fever in the eastern region of Saudi Arabia. (23960643)
2011
9
Incidence and clinical manifestations of rheumatic fever: a 6 year community-based survey. (20550029)
2010
10
Surgical repositioning of a traumatically intruded permanent incisor in a patient with rheumatic fever: case report. (19208001)
2009
11
Acute rheumatic fever and rheumatic heart disease in Fiji: prospective surveillance, 2005-2007. (19203310)
2009
12
Acute rheumatic fever and rheumatic heart disease in indigenous populations. (19962028)
2009
13
Crucial role of the CB3-region of collagen IV in PARF-induced acute rheumatic fever. (19252743)
2009
14
The role of echocardiography in diagnosing carditis in the setting of acute rheumatic fever. (19493365)
2009
15
Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever. (18400635)
2008
16
Comprehensive analysis of antibody responses to streptococcal and tissue antigens in patients with acute rheumatic fever. (18245783)
2008
17
Fulminant mitral regurgitation due to ruptured chordae tendinae in acute rheumatic fever. (17854408)
2008
18
Molecular typing of Streptococcus pyogenes from remote Aboriginal communities where rheumatic fever is common and pyoderma is the predominant streptococcal infection. (17306049)
2007
19
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. (17545263)
2007
20
Rheumatic fever and rheumatic heart disease: primary prevention is the cost effective option. (17595500)
2007
21
Management of patients with rheumatic fever and rheumatic heart disease in Nigeria--need for a national system of primary, secondary and tertiary prevention. (16607438)
2006
22
Acute rheumatic fever mimicking an acute coronary syndrome. (16858082)
2006
23
The challenge of acute rheumatic fever diagnosis in a high-incidence population: a prospective study and proposed guidelines for diagnosis in Australia's Northern Territory. (16574535)
2006
24
DRB1, DQA1, DQB1 genes in Turkish children with rheumatic fever. (15789899)
2005
25
Infective endocarditis: diagnosis, antimicrobial therapy, and management of complications: a statement for healthcare professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, and the Councils on Clinical Cardiology, Stroke, and Cardiovascular Surgery and Anesthesia, American Heart Association: endorsed by the Infectious Diseases Society of America. (15956145)
2005
26
The role of echocardiography in diagnosing carditis in the setting of acute rheumatic fever. (16297251)
2005
27
Acute rheumatic fever in children: recognition and treatment. (15612837)
2004
28
Temporal association of the appearance of mucoid strains of Streptococcus pyogenes with a continuing high incidence of rheumatic fever in Utah. (14993572)
2004
29
Obsessive-compulsive spectrum disorders in rheumatic fever with and without Sydenham's chorea. (15291690)
2004
30
Acute rheumatic fever and Henoch-Schnlein purpura. (12801126)
2003
31
Effects of IgM from rheumatic fever patients on intracellular calcium levels of neonatal rat cardiac myocytes. (12899933)
2003
32
The potential for vaccine development against rheumatic fever. (11999099)
2002
33
Presence of the d8/17 B-cell marker in children with rheumatic fever in Israel. (12030895)
2002
34
Could Tourette syndrome be a neurologic manifestation of rheumatic fever? (11530437)
2001
35
Rheumatic fever in a high incidence population: the importance of monoarthritis and low grade fever. (11517105)
2001
36
Rheumatic fever--is it still a problem? (10759358)
2000
37
Diagnosis of rheumatic fever: current status of Jones Criteria and role of echocardiography. (11129913)
2000
38
Culturing the throat to protect the heart: Dr. Milton Markowitz and the prevention of rheumatic fever. (11100629)
2000
39
Post-streptococcal reactive arthritis: a clinical and serological description, revealing its distinction from acute rheumatic fever. (10205588)
1999
40
Rheumatic fever: a multicenter study in the state of SALo Paulo. Pediatric Committee--SALo Paulo Pediatric Rheumatology Society. (10668278)
1999
41
Rheumatic fever. (10386692)
1999
42
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
43
Ethnic differences in expression of susceptibility marker(s) in rheumatic fever/rheumatic heart disease patients. (9579811)
1998
44
Rheumatic fever. The relationships between host, microbe, and genetics. (9606757)
1998
45
Doppler echocardiography distinguishes between physiologic and pathologic "silent" mitral regurgitation in patients with rheumatic fever. (9383585)
1997
46
Cytokines in acute rheumatic fever. (9007485)
1997
47
Simultaneous occurrence of acute poststreptococcal glomerulonephritis and acute rheumatic fever. (3706418)
1986
48
Rheumatic heart disease in scarlet-fever patients treated with penicillin; a follow-up study after seven years. (14383982)
1955
49
Prophylaxis of rheumatic fever and subacute bacterial endocarditis. (18109922)
1949
50
CASE of RHEUMATIC FEVER COMPLICATED by CHOREA, IRITIS, and ENDOCARDITIS: RECOVERY. (20760748)
1903

Genetic Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Sources:
51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Rheumatic Fever

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Sources:
11DrugBank, 49PharmGKB, 44Novoseek, 24HMDB, 28IUPHAR
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Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1Palivizumab1110.6FCGR2A, FCGR3B
2Intravenous Immunoglobulin1110.6FCGR3B, FCGR2A
3Ibritumomab1110.6FCGR3B, FCGR2A
4bevacizumab49 1111.6FCGR3B, FCGR2A
5tositumomab49 1111.5FCGR3B, FCGR2A
6n-acetylglucosamine4410.5FCN1, MBL2, FCN2
7alefacept44 1111.5FCGR3B, FCGR2A
8Muromonab1110.5FCGR2A, FCGR3B
9nadph44 2411.5FCGR2A, TLR2, ADM, PGD
10mannan4410.5MASP2, MBL2, FCN3, FCN2, TLR2
11efalizumab44 1111.4FCGR2A, FCGR3B
12daclizumab44 1111.4FCGR2A, FCGR3B
13mannose4410.4FCGR3B, MASP2, MBL2, TLR2, FCGR2A
14serine4410.4FCGR2A, FCGR3B, MASP2, EGR3, TLR2
15superoxide44 2411.4TLR2, MBL2, PGD, ADM, FCGR3B
16basiliximab44 1111.4FCGR3B, FCGR2A
17polysaccharide4410.3FCN2, TLR2, MBL2, FCN3, FCGR3B, FCGR2A
18fibrinogen4410.3MYOM2, FCN2, FCN1, TLR2, MASP2, MBL2
19gemtuzumab ozogamicin44 1111.3FCGR3B, FCGR2A
20alemtuzumab44 1111.3FCGR2A, FCGR3B
21h2o24410.3TLR2, FCGR2A, FCGR3B, ADM, PGD
22prednisolone44 28 1112.1MBL2, FCGR2A, FCGR3B
23natalizumab44 1111.0FCGR3B, FCGR2A

GO Terms for genes affiliated with Rheumatic Fever

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16Gene Ontology
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Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:00094010.1SKA1, SKA3, SKA2
2collagenGO:00558110.0MBL2, FCN3, FCN2, FCN1
3extracellular regionGO:0055769.9MBL2, FCN3, FCGR3B, FCN2, FCN1, ADM
4spindle microtubuleGO:0058769.8SKA3, SKA1, SKA2

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MBL2, TLR2
2opsonizationGO:00822810.3MBL2, FCN2, FCN1
3complement activation, lectin pathwayGO:00186710.2FCN1, FCN2, FCN3, MASP2, MBL2
4complement activationGO:00695610.2MBL2, MASP2, FCN3, FCN2, FCN1
5regulation of microtubule polymerization or depolymerizationGO:03111010.1SKA2, SKA1, SKA3
6chromosome segregationGO:0070599.8SKA2, SKA1, SKA3
7innate immune responseGO:0450879.8FCN1, FCGR2A, FCN3, TLR2, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.3FCGR3B, FCGR2A
2calcium-dependent protein bindingGO:04830610.1MBL2, MASP2, FCN2
3protein bindingGO:0055158.9TLR2, MBL2, AKAP17A, MASP2, MYOM2, SKA2

Products for genes affiliated with Rheumatic Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet