MCID: RHM001
MIFTS: 62

Rheumatic Fever malady

Rare diseases, Cardiovascular diseases, Bone diseases categories
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Summaries for Rheumatic Fever

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Sources:
65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to systemic lupus erythematosus and rheumatic congestive heart failure, and has symptoms including pallor, facial pain/cephalalgia/migraine and anorexia. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Complement and coagulation cascades and Phagocytosis of Microbes. The drugs aspirin and choline salicylate and the compounds zymosan and polymyxin b have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin.

Description from OMIM:47 268240

Aliases & Classifications for Rheumatic Fever

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Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 59SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

49
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


Aliases & Descriptions:

rheumatic fever 8 43 10 45 49 47 62
acute rheumatic fever 8 43 45 49
rheumatic fever without mention of heart involvement 8
rheumatic fever without heart involvement 8
acute rheumatic fever nos 8
acute rheumatic arthritis 8
rheumatic fever, active 8
inflammatory rheumatism 43
active rheumatic fever 8
rhf - rheumatic fever 8


External Ids:

Disease Ontology8 DOID:1586
ICD9CM27 390-392.99
NCIt40 C34984
MeSH35 D012213
SNOMED-CT via Orphanet59 58718002
ICD10 via Orphanet26 I01.0, I00, I01.1 I01.2, I01.8, I01.9, more
UMLS via Orphanet63 C0035436
OMIM47 268240
MESH via Orphanet36 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 117)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.5FCGR3B
2rheumatic congestive heart failure30.4MBL2
3rheumatoid arthritis30.2TLR2, FCGR3B, MBL2
4meningitis30.1MBL2, TLR2
5vasculitis30.1FCGR3B, MBL2
6rheumatic heart disease10.9
7rheumatic disease10.8
8arthritis10.7
9endocarditis10.6
10chorea10.6
11scarlet fever10.6
12pharyngitis10.5
13reactive arthritis10.5
14kawasaki disease10.5
15glomerulonephritis10.5
16rheumatic myocarditis10.5
17sydenham's chorea10.5
18subacute bacterial endocarditis10.4
19chorea minor10.4
20antiphospholipid syndrome10.3
21pulmonary edema10.3
22acute poststreptococcal glomerulonephritis10.3
23infective endocarditis10.3
24atrioventricular block10.3
25collagen disease10.3
26lupus erythematosus10.3
27pericarditis10.3
28purpura10.3
29chronic rheumatic pericarditis10.2
30septic arthritis10.2
31acute orbital inflammation10.2
32aortic valve stenosis10.2
33congenital heart disease10.2
34pyoderma10.2
35syncope10.2
36connective tissue disease10.2
37malaria10.1TLR2
38neisseria meningitidis infection10.1MBL2, TLR2
39aspergillosis10.1MBL2, TLR2
40bronchiectasis10.1TLR2, MBL2
41otitis media10.1MBL2, TLR2
42pulmonary tuberculosis10.1MBL2, TLR2
43hepatitis b10.1TLR2, MBL2
44decubitus ulcer10.0
45cardiac tamponade10.0
46diabetic ketoacidosis10.0
47nodular nonsuppurative panniculitis10.0
48familial mediterranean fever10.0
49iritis10.0
50hemoglobin c disease10.0

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Symptoms for Rheumatic Fever

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Sources:
47OMIM, 49Orphanet
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Symptoms by clinical synopsis from OMIM:

268240

Clinical features from OMIM:

268240

Symptoms:

49 (show all 36)
  • pallor
  • facial pain/cephalalgia/migraine
  • anorexia
  • nephrotic syndrome
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • endocardium anomalies/fibroelastosis/endocarditis
  • pharyngitis
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • hemiballism/unilateral movement disorders
  • alexia/agraphia/writing/reading troubles
  • epistaxis/nose bleeding
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • myocardium anomalies/myocarditis
  • asthenia/fatigue/weakness
  • absent/hypotonic/flaccid abdominal wall muscles
  • arthritis/synovitis/synovial proliferation
  • psychic/behavioural troubles
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • abnormal gait
  • constipation
  • myoclonus/fasciculations
  • fever/chilling
  • articular/joint pain/arthralgia
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • acute abdominal pain/colic
  • thoracic/chest pain
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • cardiac valvulopathy
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • macules
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Rheumatic Fever

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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33MalaCards
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MalaCards organs/tissues related to Rheumatic Fever:

33
Heart, Brain, Skin, Bone, Lung, B cells, T cells, Testes, Cardiac myocytes, Monocytes, Tonsil

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Sources:
52PubMed
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Articles related to Rheumatic Fever:

(show top 50)    (show all 539)
idTitleAuthorsYear
1
Accelerated junctional rhythm in children with acute rheumatic fever: is it specific to the disease? (23694767)
2013
2
Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971). (23610223)
2013
3
Adult-onset acute rheumatic fever. (23037480)
2012
4
Rheumatic Fever Follow-Up Study (RhFFUS) protocol: a cohort study investigating the significance of minor echocardiographic abnormalities in Aboriginal Australian and Torres Strait Islander children. (23186515)
2012
5
Rheumatic fever recurrence prevention: a nurse-led programme of 28-day penicillin in an area of high endemnicity. (21470327)
2011
6
Complete heart block complicating Acute Rheumatic Fever. (22085189)
2011
7
Persistence of acute rheumatic fever in a tertiary children's hospital. (21199062)
2011
8
Health-related quality of life of school- age children with rheumatic Fever. (21244818)
2010
9
Clinical presentation of rheumatic fever in an endemic area. (19880393)
2010
10
Underdiagnosis of acute rheumatic fever in primary care settings in a developing country. (19735369)
2009
11
Surgical repositioning of a traumatically intruded permanent incisor in a patient with rheumatic fever: case report. (19208001)
2009
12
School-based prevention of acute rheumatic fever: a group randomized trial in New Zealand. (19710585)
2009
13
Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever. (18400635)
2008
14
Rheumatic fever in a 2-year-old child. (17952489)
2008
15
What is the true frequency of carditis in acute rheumatic fever? A prospective clinical and Doppler blind study of 56 children with up to 60 months of follow-up evaluation. (18825449)
2008
16
The willow as a Hottentot (Khoikhoi) remedy for rheumatic fever. (18515781)
2008
17
Rheumatic fever and social justice. (17547542)
2007
18
Management of patients with rheumatic fever and rheumatic heart disease in Nigeria--need for a national system of primary, secondary and tertiary prevention. (16607438)
2006
19
Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)
2006
20
Obsessive-compulsive symptoms in adults with rheumatic fever. (16774666)
2006
21
B-cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settings. (16719750)
2006
22
Changing epidemiology of acute rheumatic fever in the United States. (16421786)
2006
23
Activity of lipid peroxidation processes and the condition of antioxidative defense system in children with rheumatic fever]. (16308440)
2005
24
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)
2005
25
Inverse relationship between the ratio of ICAM-1 expressing lymphocytes and serum TGF-beta 1 concentrations in acute rheumatic fever. (16023325)
2005
26
Is it possible to prevent rheumatic fever? (15751529)
2004
27
Acute rheumatic fever in children: recognition and treatment. (15612837)
2004
28
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review. (12768947)
2003
29
Serum cardiac troponin I in acute rheumatic fever. (12450620)
2002
30
Current issues in the prevention of rheumatic fever. (12410170)
2002
31
The potential for vaccine development against rheumatic fever. (11999099)
2002
32
Can we eradicate rheumatic fever in the 21st century? (11428492)
2001
33
Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. (11380924)
2001
34
Rheumatic fever recurrence: a possible cause of restenosis after percutaneous mitral valvuloplasty. (11770870)
2001
35
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
36
Prophylactic efficiency of 3-weekly benzathine penicillin G in rheumatic fever. (10838716)
2000
37
The psychiatric symptoms of rheumatic fever. (11097972)
2000
38
Urticarial eruption associated with rheumatic fever in a child. (10469414)
1999
39
T. Duckett Jones and his criteria for the diagnosis of acute rheumatic fever. (9926367)
1999
40
Rheumatic fever chemoprophylaxis in adults. (12152837)
1998
41
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
42
Advanced atrioventricular block in a 39-year-old man with acute rheumatic fever. (9826853)
1998
43
Chronic meningococcemia mimicking acute rheumatic fever. (9753830)
1998
44
Search for linkage disequilibrium between alleles in the T cell receptor alpha and beta chain loci and susceptibility to rheumatic fever. (7493775)
1995
45
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
46
Release of oxygen free radicals by macrophages and neutrophils in patients with rheumatic fever. (1915447)
1991
47
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
48
Rheumatic fever as a collagen disease. (13339200)
1956
49
Rheumatic fever as a collagen disease. (13229241)
1954
50
Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. (14780325)
1950

Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Sources:
50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 55Reactome, 60Thomson Reuters, 57SinoBiological
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Compounds for genes affiliated with Rheumatic Fever

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Sources:
45Novoseek, 29IUPHAR, 61Tocris Bioscience, 24HMDB, 11DrugBank, 51PharmGKB
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Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 19)
idCompoundScoreTop Affiliating Genes
1zymosan4510.0MBL2, TLR2
2polymyxin b459.9MBL2, TLR2
3lipoteichoic acid459.9MBL2, TLR2
4anti-fungal459.9TLR2, MBL2
5peptidoglycan45 2910.9MBL2, TLR2
6latex459.8MBL2, TLR2
7n-acetylglucosamine459.7FCN2, MBL2
8agarose459.7MBL2, TLR2
9leukotriene b445 61 2411.6FCGR3B, TLR2
10sialic acid459.5MBL2, FCN2
11prednisolone45 29 1111.5FCGR3B, MBL2
12carbohydrates459.3MBL2, MASP2
13superoxide45 2410.3TLR2, FCGR3B, MBL2
14fibrinogen458.9TLR2, FCN2, MASP2, MBL2
15mannose458.9MBL2, MASP2, FCGR3B, TLR2
16mannan458.5MBL2, MASP2, FCN3, FCN2, TLR2
17polysaccharide458.4TLR2, FCGR3B, FCN2, FCN3, MBL2
18calcium45 51 24 1111.3TLR2, FCGR3B, FCN2, MASP2, MBL2
19serine457.1TLR2, FCGR3B, FCN2, FCN3, MASP2, MBL2

GO Terms for genes affiliated with Rheumatic Fever

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16Gene Ontology
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Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725629.5FCN3, FCN2
2collagenGO:0055819.0MBL2, FCN3, FCN2
3extracellular regionGO:0055767.7FCGR3B, FCN2, FCN3, MASP2, MBL2

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:0441309.6TLR2, MBL2
2opsonizationGO:0082289.6MBL2, FCN2
3complement activation, classical pathwayGO:0069589.6MBL2, MASP2
4defense response to Gram-positive bacteriumGO:0508309.4MBL2, TLR2
5complement activation, lectin pathwayGO:0018678.8MBL2, MASP2, FCN3, FCN2
6complement activationGO:0069568.7FCN2, FCN3, MASP2, MBL2
7innate immune responseGO:0450878.3TLR2, FCN2, FCN3, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1carbohydrate bindingGO:0302469.5FCN3, FCN2
2calcium-dependent protein bindingGO:0483068.8MBL2, MASP2, FCN2

Products for genes affiliated with Rheumatic Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Fever

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet