MCID: RHM001
MIFTS: 58

Rheumatic Fever malady

Categories: Rare diseases, Cardiovascular diseases, Bone diseases

Aliases & Classifications for Rheumatic Fever

About this section
Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 29ICD9CM, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet, 28ICD10 via Orphanet, 37MESH via Orphanet
See all MalaCards sources

Aliases & Descriptions for Rheumatic Fever:

Name: Rheumatic Fever 10 45 47 12 51 36 65
Acute Rheumatic Fever 10 45 47 51
 
Inflammatory Rheumatism 45
Rhf - Rheumatic Fever 10

Characteristics:

Orphanet epidemiological data:

51
rheumatic fever:
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe),1-5/10000 (Canada),1-5/10000 (Spain),>1/1000 (Australia),1-5/10000 (India),>1/1000 (Mexico),1-9/100000 (Latin America),1-9/100000 (New Zealand); Age of onset: Childhood; Age of death: adult

Classifications:



External Ids:

Disease Ontology10 DOID:1586
ICD1027 I00, I00-I02
ICD9CM29 390, 390-392.99
MeSH36 D012213
NCIt42 C34984
Orphanet51 3099
UMLS via Orphanet66 C0035436
ICD10 via Orphanet28 I00, I01.0, I01.1 I01.2, I01.8, I01.9, more
MESH via Orphanet37 D012213
UMLS65 C0035436, C0264743

Summaries for Rheumatic Fever

About this section
NIH Rare Diseases:45 Rheumatic fever is an inflammatory condition that may develop after infection with group a streptococcus bacteria, such as strep throat or scarlet fever. it is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. it is not clear why some people who are infected with group a streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. treatment usually includes antibiotics and/or anti-inflammatory medications. last updated: 1/11/2015

MalaCards based summary: Rheumatic Fever, also known as acute rheumatic fever, is related to scleritis and dextrocardia, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, macules and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Rheumatic Fever is MBL2 (Mannose Binding Lectin 2), and among its related pathways are Inflammatory Response Pathway and Immune response_MIF-mediated glucocorticoid regulation. The drugs aspirin and choline salicylate have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related mouse phenotype immune system.

Wikipedia:68 Rheumatic fever, also known as acute rheumatic fever (ARF), is an inflammatory disease that can involve... more...

Related Diseases for Rheumatic Fever

About this section

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 194)
idRelated DiseaseScoreTop Affiliating Genes
1scleritis30.4CD40LG, MBL2
2dextrocardia29.6FCN2, MBL2, TLR2, TNF
3congenital heart block29.3CD40LG, IL2, MBL2, TNF
4rheumatoid arthritis29.0CD40LG, HLA-DQA1, IL2, TLR2, TNF
5systemic lupus erythematosus28.4CD40LG, FCN3, HLA-DQA1, IL2, MBL2, TNF
6rheumatic myocarditis11.6
7acute articular rheumatism11.4
8sydenham's chorea11.1
9hypophosphatasia10.8MBL2, TNF
10waardenburg syndrome type 410.7MBL2, TNF
11malignant sertoli-leydig cell tumor of ovary10.7MYOM2, TNF
12drug-induced mental disorder10.7HLA-DQA1, TNF
13hair defect with photosensitivity and mental retardation10.7TLR2, TNF
14protein r deficiency10.7MBL2, TLR2
15anti-hla hyperimmunization10.7TLR2, TNF
16tuberculous uveitis10.7TLR2, TNF
17heart disease10.7
18streptococcal meningitis10.7MBL2, TNF
19rheumatic heart disease10.7
20noonan-like/multiple giant cell lesion syndrome10.6TLR2, TNF
21cryptosporidiosis10.6HLA-DQA1, TNF
22acrofrontofacionasal dysostosis10.6MASP2, MBL2
23neonatal adrenoleukodystrophy10.6MBL2, TLR2
24occipital lobe neoplasm10.6TLR2, TNF
25erdheim-chester disease10.6CD40LG, TNF
26sjogren's syndrome10.6CD40LG, TNF
27immunotactoid glomerulopathy10.6CD40LG, MBL2
28congenital nasal pyriform aperture stenosis with holoprosencephaly10.6MBL2, TNF
29rhinoscleroma10.6CD40LG, TNF
30duodenum cancer10.6HLA-DQA1, TNF
31ureterocele10.5IL2, TNF
32refractory plasma cell neoplasm10.5CD40LG, TNF
33cauda equina syndrome10.5CD40LG, MBL2
34bartonellosis10.5CD40LG, TLR2
35membranous glomerulonephritis10.5CD40LG, TNF
36immunoglobulin beta deficiency10.5CD40LG, MBL2
37ileocolitis10.5TLR2, TNF
38rumination disorder10.5CD40LG, TLR2
39collagenous colitis10.5IL2, TNF
40hemorrhagic proctocolitis10.5CD40LG, TNF
41cogan-reese syndrome10.5CD40LG, TNF
42periodontal disease10.5MBL2, TLR2, TNF
43diffuse intraductal papillomatosis10.5CD40LG, TNF
44trachoma10.5MBL2, TLR2, TNF
45soft palate cancer10.4CD40LG, TNF
46argentine hemorrhagic fever10.4IL2, TNF
47temporal arteritis10.4CD40LG, TLR2
48keratinizing squamous cell carcinoma10.4MBL2, TLR2, TNF
49liver fibroma10.4HLA-DQA1, TLR2, TNF
50vulvovaginitis10.4IL2, MBL2

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Symptoms for Rheumatic Fever

About this section

Symptoms:

 51 (show all 36)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • acute abdominal pain/colic
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • pallor
  • absent/hypotonic/flaccid abdominal wall muscles
  • constipation
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding

UMLS symptoms related to Rheumatic Fever:


pathergy reaction, osler's node

Drugs & Therapeutics for Rheumatic Fever

About this section

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50)    (show all 66)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1Liver ExtractsPhase 43572
2
MethotrexateapprovedPhase 314441959-05-2, 59-05-2126941
Synonyms:
4-amino-10-methylfolic acid
4-amino-N(10)-Methylpteroylglutamic acid
Abitrexate
Amethopterin
Amethopterine
Antifolan
Arbitrexate
Emtexate
Folex
HDMTX
L-Amethopterin
Ledertrexate
MTX
Metatrexan
Methopterin
Methotextrate
 
Methotrate
Methotrexat
Methotrexate
Methotrexate Sodium
Methotrexatum
Methylaminopterin
Methylaminopterinum
Metoject
Metotrexato
Mexate
Méthotrexate
N-Bismethylpteroylglutamic Acid
N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid
Otrexup
Rasuvo
Rheumatrex
Rheumatrex Dose Pack
Trexall
3
Etanerceptapproved, investigationalPhase 3383185243-69-0
Synonyms:
185243-69-0
CD120b
D00742
Enbrel
Enbrel (TN)
Enbrel Sureclick
Etanercept
Etanercept (USAN/INN)
 
Etanercept (genetical recombination)
Etanercept (genetical recombination) (JAN)
TNF-R2
Tumor necrosis factor receptor 2
Tumor necrosis factor receptor superfamily member 1B precursor
Tumor necrosis factor receptor type II
etanercept
p75
p80 TNF-alpha receptor
4
InfliximabapprovedPhase 3349170277-31-3
Synonyms:
Ig gamma-1 chain C region
 
Inflectra
Remicade
Remsima
5
Folic Acidapproved, nutraceuticalPhase 3292459-30-36037
Synonyms:
(2S)-2-[[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
01769_FLUKA
2d0k
33609-88-0
36653-55-1 (mono-potassium salt)
59-30-3
6484-89-5 (mono-hydrochloride salt)
AC-11682
AC1L1LNX
AI3-26387
AKOS000503224
ARONIS014410
Acfol (Spain)
Acide folique
Acide folique [INN-French]
Acido folico
Acido folico [INN-Spanish]
Acidum folicum
Acidum folicum [INN-Latin]
Acifolic
Antianemia factor
Apo-Folic
BIDD:ER0563
BIDD:GT0641
BIF0608
BPBio1_000654
BSPBio_000594
BSPBio_002338
C00504
C20H20N6O6
CAS-59-30-3
CCRIS 666
CHEBI:27470
CHEMBL1622
CID6037
CPD000471860
Cytofol
D00070
DB00158
DivK1c_000494
Dosfolat B activ
EINECS 200-419-0
F0043
F7876_SIAL
F7876_SIGMA
F8758_SIGMA
F8798_SIAL
F8890_SIGMA
FOL
Facid
Factor U
Folacid
Folacin
Folaemin
Folaemin [Netherlands]
Folan
Folasic (Australia)
Folate
Folbal
Folcidin
Folcidin (VAN)
Folcysteine
Foldine
Foldine [France]
Folettes
Foliamin
Folic
Folic Acid
Folic acid
Folic acid (JP15/USP/INN)
Folic acid (TN)
Folic acid [BAN:INN:JAN]
Folic acid [INN:BAN:JAN]
Folic acid dihydrate
Folicet
Folicet (TN)
Folico
Folico (Italy)
Folina
Folina (Italy)
Folipac
 
Folsaeure
Folsan
Folsaure
Folsav
Folvite
Folvron
Glutamic acid, N-(p-(((2-amino-4-hydroxypyrimido(4,5-b)pyrazin-6-yl)methyl)amino)benzoyl)-, L
HMS1921D20
HMS2092N17
HMS501I16
HSDB 2002
IDI1_000494
InChI=1/C19H19N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,8,12,21H,5-7H2,(H,24,29)(H,27,28)(H,31,32)(H3,20,22,25,26,30)/t12-/m0/s
Incafolic
KBio1_000494
KBio2_001861
KBio2_004429
KBio2_006997
KBio3_001558
KBioGR_002222
KBioSS_001861
Kyselina listova
Kyselina listova [Czech]
LS-2157
Liver Lactobacillus casei factor
MLS001304016
MLS001335861
Millafol
Mission prenatal
Mittafol
MolPort-004-285-551
N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzo- yl)-L-glutamic acid
N-(4-((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-(4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
N-(p-(((2-Amino-4-hydroxy-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid
N-Pteroyl-L-glutamic acid
N-[(4-{[(2-Amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[(4-{[(2-amino-4-oxo-1,4-dihydropteridin-6-yl)methyl]amino}phenyl)carbonyl]-L-glutamic acid
N-[4-[[(2-Amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid
NCGC00016265-01
NCGC00142391-01
NINDS_000494
NSC 3073
Nifolin
Nifolin [Denmark]
Novofolacid
Novofolacid [Canada]
PGA
PGA (VAN)
Prestwick3_000627
Prestwick_230
PteGlu
Pteroyl-L-glutamate
Pteroyl-L-glutamic acid
Pteroyl-L-monoglutamate
Pteroyl-L-monoglutamic acid
Pteroylglutamate
Pteroylglutamic acid
Pteroylmonoglutamate
Pteroylmonoglutamic acid
SAM002264616
SDCCGMLS-0066738.P001
SMP2_000137
SMR000471860
SPBio_001357
SPECTRUM1502020
Serum Folate Level
Spectrum2_001459
Spectrum3_000749
Spectrum4_001751
Spectrum5_000602
Spectrum_001381
UNII-935E97BOY8
Usaf cb-13
Vitamin B11
Vitamin B9
Vitamin Bc
Vitamin Be
Vitamin M
bmse000299
folic acid
nchembio.108-comp10
6Antibodies, MonoclonalPhase 3, Phase 1, Phase 22413
7AntibodiesPhase 3, Phase 1, Phase 24477
8Interleukin 1 Receptor Antagonist ProteinPhase 2, Phase 335
9Peripheral Nervous System AgentsPhase 3, Phase 118510
10ImmunoglobulinsPhase 3, Phase 1, Phase 24477
11AntimetabolitesPhase 39454
12AnalgesicsPhase 39358
13Analgesics, Non-NarcoticPhase 35184
14Anti-Inflammatory AgentsPhase 38478
15Immunosuppressive AgentsPhase 310422
16Anti-Inflammatory Agents, Non-SteroidalPhase 33549
17Antirheumatic AgentsPhase 3, Phase 28496
18Gastrointestinal AgentsPhase 36401
19Immunologic FactorsPhase 3, Phase 218483
20Vitamin B ComplexPhase 32847
21Nucleic Acid Synthesis InhibitorsPhase 33836
22Folic Acid AntagonistsPhase 31643
23Antimetabolites, AntineoplasticPhase 35770
24Dermatologic AgentsPhase 34555
25Folinic AcidNutraceuticalPhase 32604
26Vitamin B9NutraceuticalPhase 32924
27FolateNutraceuticalPhase 32924
28
AcetylcysteineapprovedPhase 2293616-91-112035
Synonyms:
(2R)-2-acetylamino-3-Sulfanylpropanoic acid
(R)-2-acetylamino-3-Mercaptopropanoic acid
(R)-Mercapturic acid
2-Acetylamino-3-mercapto-propionate
2-Acetylamino-3-mercapto-propionic acid
ACC
Acetadote
Acetilcisteina
Acetylcysteine
Acetylcysteinum
Fluimicil Infantil
Fluimucetin
Fluimucil
Flumucetin
 
Fluprowit
L-Acetylcysteine
L-alpha-acetamido-beta-Mercaptopropionic acid
Lysox
Mercapturic acid
Mucolysin
Mucomyst
N-ACETYL-L-cysteine
N-Acety-L-Cysteine
N-Acetyl-3-mercaptoalanine
N-Acetyl-L-(+)-cysteine
N-Acetylcysteine
N-acetylcysteine
NAC
Parvolex
Sodium 2-acetamido-3-mercaptopropionate
29N-monoacetylcystinePhase 2293
30Protective AgentsPhase 25651
31VaccinesPhase 26085
32Pharmaceutical SolutionsPhase 2, Phase 17004
33Respiratory System AgentsPhase 2, Phase 13931
34ExpectorantsPhase 2337
35Antiviral AgentsPhase 28071
36penicillinsPhase 292
37Anti-Infective AgentsPhase 217220
38AntioxidantsPhase 22442
39glutamineNutraceuticalPhase 2144
40alanineNutraceuticalPhase 2106
41
EpinephrineapprovedPhase 183451-43-45816
Synonyms:
(-)-(R)-Epinephrine
(-)-3,4-Dihydroxy-a-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol
(-)-3,4-Dihydroxy-alpha-[2-(methylamino)ethyl]benzyl alcohol
(-)-3,4-dihydroxy-a-[(methylamino)methyl]-Benzyl alcohol
(-)-3,4-dihydroxy-alpha-[(methylamino)methyl]-Benzyl alcohol
(-)-Adrenalin
(-)-Adrenaline
(-)-Epinephrine
(-)-R-Epinephrine
(R)-(-)-Adnephrine
(R)-(-)-Adrenaline
(R)-(-)-Epinephrine
(R)-(-)-Epirenamine
(R)-(−)-adrenaline
(R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
(R)-4-[1-hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
(R)-Adrenaline
(R)-Epinephrine
(−)-adrenaline
02252_FLUKA
1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
1-Adrenalin
1-Epinephrine
4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol
4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-Benzenediol
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol
4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
51-43-4
51-43-4 (FREE BASE)
51028-73-0
A0173
AC-13188
AC1L1L7B
ADR ADRENALINE
ADROP
AI3-19015
Adnephrine
Adrenaclick
Adrenal
Adrenalin
Adrenalin (TN)
Adrenalin in Oil
Adrenalin-Medihaler
Adrenalina
Adrenalina [DCIT]
Adrenaline
Adrenaline (JP15)
Adrenaline/Epinephrine
Adrenalinum
Adrenamine
Adrenan
Adrenapax
Adrenasol
Adrenatrate
Adrenine
Adrenodis
Adrenohorma
Adrenosan
Adrenutol
Adrin
Adrine
Ana-Guard
Ana-Kit
Antiasthmatique
Asmatane Mist
Asthma meter mist
Asthma-nefrin
Asthmahaler Mist
Asthmanefrin
Astmahalin
Astminhal
Auvi-q
BIDD:GT0119
Balmadren
Bernarenin
Biorenine
Bosmin
Brevirenin
Bronkaid
Bronkaid Mist
Bronkaid Suspension Mist
Bupivacaine Hcl and Epinephrine
C00788
CCRIS 4812
CHEBI:28918
CHEMBL679
CID5816
Chelafrin
Citanest Forte
Corisol
D-Epifrin
D-Epinephrine
D00095
DB00668
Drenamist
Dylephrin
Dyspne-Inhal
E4250_SIGMA
EINECS 200-098-7
EPI E Z PEN JR
EPIPEN E Z PEN
EPIPEN JR
Epi EZ Pen Jr
Epifrin
Epiglaufrin
Epinefrin
Epinefrin [Czech]
Epinefrina
Epinefrina [INN-Spanish]
Epinephran
Epinephrin
Epinephrine
Epinephrine (USP)
Epinephrine (USP/INN)
Epinephrine [USAN:INN:JAN]
Epinephrine bitartrate
Epinephrine chloride
Epinephrine hydrochloride
Epinephrinum
Epinephrinum [INN-Latin]
Epipen
Epipen (TN)
Epipen Auto-Injector
Epipen EZ Pen
Epipen Jr
Epipen Jr.
Epipen Jr. Auto-Injector
Epipen jr
Epirenamine
Epirenan
Epirenin
Epitrate
Eppy
 
Esphygmogenina
Exadrin
Glaucon
Glaucosan
Glauposine
Glycirenan
HSCI1_000215
HSDB 4289
Haemostasin
Haemostatin
Hektalin
Hemisine
Hemostasin
Hemostatin
Hypernephrin
Hyporenin
IOP
Intranefrin
Iontocaine
Isoptoepinal
Kidoline
L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
L-Adrenaline
L-Adrenaline Base
L-Epinehphrine
L-Epinephrine
L-Epirenamine
L-Methylaminoethanolcatechol
L-epinephrine
LS-156
Levo-Methylaminoethanolcatechol
Levoadrenaline
Levoepinephrine
Levorenen
Levorenin
Levorenine
Levoreninum
Lopac-E-4642
Lyodrin
Lyophrin
Medihaler-Epi
Metanephrin
Methylaminoethanolcatechol
Methylarterenol
Micronefrin
Micronephrine
MolPort-002-051-368
Mucidrina
Myosthenine
Mytrate
NCGC00015417-01
NCGC00142615-01
NCGC00142615-03
NCGC00142615-04
NCGC00142615-05
NCGC00142615-06
NCGC00142615-07
NSC 62786
NSC62786
Nephridine
Nieraline
PDSP1_001120
PDSP2_001104
Paranephrin
Primatene
Primatene Mist
Primatene Mist Refill
Prime Asthma Relief
R-(-)-Epinephrine
R-Adrenaline
RCRA waste no. P042
Racemic Epinephrine
Racepinephrine
Rcra waste number P042
Renagladin
Renaglandin
Renaglandulin
Renaleptine
Renalina
Renoform
Renostypricin
Renostypticin
Renostyptin
SMP1_000227
ST069368
SUS-PHRINE SULFITE-FREE
Scurenaline
Septocaine
Simplene
Sindrenina
Soladren
Sphygmogenin
Stryptirenal
Styptirenal
Supracapsulin
Supradin
Supranefran
Supranephrane
Supranephrine
Supranol
Suprarenaline
Suprarenin
Suprel
Surenine
Surrenine
Sus-Phrine
Sus-phrine
Susphrine
Sympathin I
Takamina
Takamine
Tokamina
Tonogen
Twinject
Twinject 0.15
Twinject 0.3
Twinject 0.30
UNII-YKH834O4BH
Vaponefrin
Vasoconstrictine
Vasoconstrictor
Vasodrine
Vasoton
Vasotonin
adrenaline
bmse000316
d-Adrenaline
epinephrine
l-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol
l-Adrenalin
l-Adrenaline
l-Epinephine
l-Epinephrine (synthetic)
l-Epirenamine
l-Methylaminoethanolcatechol
levoepinephrine
nchembio747-comp9
42
LidocaineapprovedPhase 11103137-58-63676
Synonyms:
.alpha.-(Diethylamino)-2,6-acetoxylidide
.alpha.-Diethylamino-2,6-dimethylacetanilide
.alpha.-Diethylaminoaceto-2,6-xylidide
.omega.-Diethylamino-2,6-dimethylacetanilide
137-58-6
2-(Diethylamino)-2',6'-acetoxylidide
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
2-Diethylamino-N-(2,6-dimethyl-phenyl)-acetamide
2-Diethylamino-N-(2,6-dimethylphenyl)acetamide
4-12-00-02538 (Beilstein Handbook Reference)
6108-05-0 (MONOHYDROCHLORIDE MONOHYDRATE))
6108-05-0 (mono-hydrochloride, mono-hydrate)
73-78-9 (mono-hydrochloride)
AB00053581
AC-10282
AC1L1GGQ
AC1Q2Z7J
AKOS001026768
ARONIS23855
After Burn Double Strength Gel
After Burn Double Strength Spray
After Burn Gel
After Burn Spray
Afterburn
Akten
Alphacaine
Anestacon
Anestacon Jelly
BIDD:GT0342
BPBio1_000197
BRD-K52662033-001-02-6
BRD-K52662033-003-05-5
BRN 2215784
BSPBio_000179
BSPBio_001359
BSPBio_003004
Bikini Zone Medicated
Bikini Zone Medicated Creme
Bio-0767
Bio-scriptives Lidum
Bio-scriptives Lidum Hemorroidal (anorectal)
Bio-scriptives Lidum Topical Analgesic
Bio1_000379
Bio1_000868
Bio1_001357
Bio2_000079
Bio2_000559
Burn Relief Leader
C07073
C14H22N2O
CAS-73-78-9
CDS1_000283
CHEBI:6456
CHEMBL79
CID3676
CPD000058189
Cappicaine
Cito optadren
Comfortcaine
Cuivasil
Curacaine Transdermal Corporation
D00358
DB00281
Dalcaine
Dentipatch
Dentipatch (TN)
Derma Numb
DermaFlex
Desert Harvest Releveum
Diethylaminoaceto-2,6-xylidide
Dilocaine
DivK1c_000174
DivK1c_001323
Dr. Numb
Dr. Richs Numbing
Duncaine
EINECS 205-302-8
ELA-Max
EMBOLEX
Emla
Emla Cream
Esracaine
FT-0082378
Gigi Anesthetic Numbing
Gravocain
H-releve Hemorrhoidal
HMS1791D21
HMS1989D21
HMS2051C21
HMS2089E15
HMS548M19
HSDB 3350
Hawaiian Tropic
Hush Anesthetic
I01-2704
IDI1_000174
IDI1_033829
Isicaina
Isicaine
Jetocaine
KBio1_000174
KBio2_000079
KBio2_001598
KBio2_002647
KBio2_004166
KBio2_005215
KBio2_006734
KBio3_000157
KBio3_000158
KBio3_002224
KBioGR_000079
KBioGR_000599
KBioSS_000079
KBioSS_001598
L-Caine
L0156
L1026_SIGMA
L7757_SIGMA
LIDOCAINE (73-58-6 (MONOHYDROCHLORIDE)
LIDOPEN
LQZ
LS-805
Lanabiotic
 
Laryng-o-jet
Leostesin
Lida-Mantle
Lidall
Lidocaina
Lidocaina [INN-Spanish]
Lidocaine
Lidocaine (JP15/USP/INN)
Lidocaine (VAN)
Lidocaine 4% Cream
Lidocaine Carbonate
Lidocaine Hydrocarbonate
Lidocaine Hydrochloride
Lidocaine Monohydrochloride
Lidocaine [USAN:INN:JAN]
Lidocaine hydrochloride
Lidocainum
Lidocainum [INN-Latin]
Lidocare Mist
Lidocaton
Lidocream 4
Lidocream 5
Lidoderm
Lidoderm 5
Lidoject-1
Lidoject-2
Lifestyles Epic Male Genital Desensitizer
Lignocaine
Lignocainum
Lingocaine
Lmx4
Lmx5
Lopac-L-5647
Lopac0_000669
MLS000069724
MLS000758263
MLS001074177
Maricaine
Maybridge1_002571
MolPort-001-783-478
N-(2,6-dimethylphenyl)-N(2),N(2)-diethylglycinamide
N-(2,6-dimethylphenyl)-N~2~,N~2~-diethylglycinamide
NCGC00015611-01
NCGC00015611-02
NCGC00015611-03
NCGC00015611-04
NCGC00015611-14
NCGC00022176-05
NCGC00022176-06
NCGC00022176-07
NCGC00022176-08
NCGC00022176-09
NINDS_000174
NSC 40030
NSC40030
Norwood Sunburn Spray
Numb Master Topical Anesthetic
Numb Nuts
Ocean Potion Instant Burn Relief Ice
Octocaine
Octocaine-100
Octocaine-50
Plum Smooth Plumb Numb Gelee
Premjact Male Desensitizer Pound International
Prestwick0_000050
Prestwick1_000050
Prestwick2_000050
Prestwick3_000050
Recticare
Remicaine
Rocephin Kit
Rucaina
S1357_Selleck
SAM001247018
SMR000058189
SPBio_001525
SPBio_002100
STK552033
Simplicity Desensitizing
Simply Numb Endure
Solarcaine
Solarcaine aloe extra burn relief cream
Solcain
Sole Serum
Spectrum2_001343
Spectrum3_001392
Spectrum4_000070
Spectrum5_001549
Spectrum_001118
UNII-98PI200987
WLN: 2N2 & 1VMR B1 F1
Walgreens Aloe Vera Pain Relieving
Xilina
Xilocaina
Xilocaina [Italian]
Xllina
Xycaine
Xylestesin
Xylesthesin
Xylocain
Xylocaine
Xylocaine (TN)
Xylocaine 5% Spinal
Xylocaine CO2
Xylocaine Dental Ointment
Xylocaine Endotracheal
Xylocaine Test Dose
Xylocaine Viscous
Xylocaine-Mpf
Xylocaine-Mpf with Glucose
Xylocaine-mpf
Xylocard
Xylocitin
Xyloneural (free base)
Xylotox
Zcaine Fast Acting Anesthetic
Zilactin-L
Zingo
alfa-Dietilamino-2,6-dimetilacetanilide
alfa-Dietilamino-2,6-dimetilacetanilide [Italian]
alpha-Diethylamino-2,6-dimethylacetanilide
alpha-diethylamino-2,6-dimethylacetanilide
lidocaine
nchembio.65-comp16
α-diethylamino-2,6-dimethylacetanilide
43Epinephryl boratePhase 1834
44Diuretics, Potassium SparingPhase 11445
45Sodium Channel BlockersPhase 11180
46Vasoconstrictor AgentsPhase 11303
47RacepinephrinePhase 1834
48Neurotransmitter AgentsPhase 114795
49MydriaticsPhase 1525
50Central Nervous System DepressantsPhase 110016

Interventional clinical trials:

(show top 50)    (show all 53)
idNameStatusNCT IDPhase
1A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab)RecruitingNCT01734382Phase 4
2Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)?CompletedNCT02164214Phase 3
3An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and WiCompletedNCT00891046Phase 3
4Study of the Safety and Efficacy of NC-503 in Secondary (AA) AmyloidosisCompletedNCT00035334Phase 2, Phase 3
5A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA)CompletedNCT00642460Phase 3
6Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITISCompletedNCT00339157Phase 2, Phase 3
7Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus PlaceboRecruitingNCT01068405Phase 3
8Infliximab Therapy in Patients With Refractory Polymyalgia RheumaticaActive, not recruitingNCT01423591Phase 3
9Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid ArthritisTerminatedNCT00078806Phase 3
10Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup)CompletedNCT00001359Phase 2
11N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve ReplacementCompletedNCT01704482Phase 2
12Validity Study of Glutamine to Improve Cardiac Function in Cardiac SurgeryCompletedNCT01794884Phase 2
13Mild Water-Filtered Near Infrared Whole-Body-Hyperthermia as an Adjunct in the Treatment of FibromyalgiaCompletedNCT00324441Phase 2
14Interleukin-1 Trap to Treat Autoinflammatory DiseasesCompletedNCT00094900Phase 2
15Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young AdultsCompletedNCT00534495Phase 2
16TIV and High Dose TIV in Subjects With Rheumatoid ArthritisCompletedNCT01436370Phase 2
17Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA)CompletedNCT00426218Phase 1, Phase 2
18Therapeutic Use of Tadekinig Alfa in Adult-onset Still's DiseaseRecruitingNCT02398435Phase 2
19Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic PatientNot yet recruitingNCT02020668Phase 2
20Efficacy and Safety of Tocilizumab in Adult's Still DiseaseNot yet recruitingNCT01002781Phase 2
21Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male VolunteersCompletedNCT01525147Phase 1
22Dental Anesthesia in Pregnant Women With Rheumatic Heart DiseaseCompletedNCT00482573Phase 1
23Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic FeverCompletedNCT01886846
24Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among SchoolchildrenCompletedNCT02353663
25Hospital Based Incidence of Group A Streptococcal Disease in FijiCompletedNCT00264771
26Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern TerritoryCompletedNCT00884728
27Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic DiseasesCompletedNCT01511341
28Genetic Susceptibility to Rheumatic Heart Disease in the Pacific RegionCompletedNCT02188862
29Surveillance of Streptococcal Infections in Children in IndiaCompletedNCT00342199
30Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence SurveyCompletedNCT01400529
31DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart DiseaseCompletedNCT00264524
32Effect of Simvastatin on Cardiac FunctionCompletedNCT01178710
33Deep Versus Superficial Heating in Patients With Knee OsteoarthritisCompletedNCT01343147
34Risk of Coccidioidomycosis in Patients Receiving Anti-TNF and Other Biologic Agents for an Inflammatory ArthritisCompletedNCT00796809
35The Genetic Basis of Acquired Heart Disease in AfricaRecruitingNCT02124109
36Regulatory B Cells in Inflammatory Rheumatisms and Biomarkers of Response to Biologic TreatmentsRecruitingNCT01642706
37RhEumatiC Heart diseAse GeneticsRecruitingNCT02118818
38Rheumatic Heart Disease Study in LusakaRecruitingNCT02661763
39Rheumatic Heart Disease Prevalence in Leon, NicaraguaRecruitingNCT00307112
40Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium EnlargementRecruitingNCT02474108
41Yellow Fever Vaccination Under Low Dose Methotrexate TherapyRecruitingNCT02383680
42A Two-step Method Apparently Improved the Physicians' Level of Diagnosis Decision-making for Adult Patients With FUORecruitingNCT02035670
43American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Diagnostic and Classification Criteria for Primary Systemic VasculitisRecruitingNCT01066208
44Phenomics in Autoimmune and Inflammatory DiseasesRecruitingNCT02466217
45Rheumatic Heart Disease School ProjectActive, not recruitingNCT01550068
46Development of Intervention Model for Osteoporosis and Fall Prevention in TaiwanActive, not recruitingNCT01206491
47The Prevalence of Rheumatic Heart Disease in School Children in FijiActive, not recruitingNCT00779662
4841.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid DiseasesActive, not recruitingNCT00000106
49Juvenile Inflammatory Rheumatism (JIR) CohorteEnrolling by invitationNCT02377245
50Efficacy of BLIS K12 as Preventive Measure for Rheumatic ChildrenNot yet recruitingNCT02407106

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS65/NDF-RT43:


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

About this section

Anatomical Context for Rheumatic Fever

About this section

MalaCards organs/tissues related to Rheumatic Fever:

33
Heart, Skin, Brain, Tonsil, B cells, Bone, T cells

Animal Models for Rheumatic Fever or affiliated genes

About this section

MGI Mouse Phenotypes related to Rheumatic Fever:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053876.4CD40LG, FCN1, HLA-DQA1, HP, IL2, MASP2

Publications for Rheumatic Fever

About this section

Articles related to Rheumatic Fever:

(show top 50)    (show all 621)
idTitleAuthorsYear
1
Significance of silent carditis and investigation of follow-up signs in acute rheumatic fever. (27097234)
2016
2
A Case of Acute Rheumatic Fever With Henoch Schonlein Purpura. (26635933)
2015
3
Controlling acute rheumatic fever and rheumatic heart disease in developing countries: are we getting closer? (25490689)
2015
4
Primary prevention of rheumatic fever in children: key factors to consider. (24897809)
2014
5
Clinically manifested myocarditis in acute rheumatic fever. (24676379)
2014
6
Accelerated junctional rhythm in children with acute rheumatic fever: is it specific to the disease? (23694767)
2013
7
Rheumatic fever in Ireland: the role of Dr Monica Lea Wilson (1889-1971). (23610223)
2013
8
Adult-onset acute rheumatic fever. (23037480)
2012
9
Rheumatic fever recurrence prevention: a nurse-led programme of 28-day penicillin in an area of high endemnicity. (21470327)
2011
10
Complete heart block complicating Acute Rheumatic Fever. (22085189)
2011
11
Persistence of acute rheumatic fever in a tertiary children's hospital. (21199062)
2011
12
Health-related quality of life of school- age children with rheumatic Fever. (21244818)
2010
13
Clinical presentation of rheumatic fever in an endemic area. (19880393)
2010
14
Underdiagnosis of acute rheumatic fever in primary care settings in a developing country. (19735369)
2009
15
Surgical repositioning of a traumatically intruded permanent incisor in a patient with rheumatic fever: case report. (19208001)
2009
16
School-based prevention of acute rheumatic fever: a group randomized trial in New Zealand. (19710585)
2009
17
Human soluble tumor necrosis factor receptor I (sTNF-RI) and interleukin-I receptor antagonist (IL-I Ra) in different stages of acute rheumatic fever. (18400635)
2008
18
Rheumatic fever in a 2-year-old child. (17952489)
2008
19
Rheumatic fever and social justice. (17547542)
2007
20
Management of patients with rheumatic fever and rheumatic heart disease in Nigeria--need for a national system of primary, secondary and tertiary prevention. (16607438)
2006
21
Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)
2006
22
Obsessive-compulsive symptoms in adults with rheumatic fever. (16774666)
2006
23
Activity of lipid peroxidation processes and the condition of antioxidative defense system in children with rheumatic fever]. (16308440)
2005
24
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)
2005
25
Is it possible to prevent rheumatic fever? (15751529)
2004
26
Rheumatic fever. (15522676)
2004
27
Acute rheumatic fever in children: recognition and treatment. (15612837)
2004
28
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review. (12768947)
2003
29
Serum cardiac troponin I in acute rheumatic fever. (12450620)
2002
30
Current issues in the prevention of rheumatic fever. (12410170)
2002
31
The potential for vaccine development against rheumatic fever. (11999099)
2002
32
Can we eradicate rheumatic fever in the 21st century? (11428492)
2001
33
Evaluation of DNA damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever. (11380924)
2001
34
Pharyngeal carriage of group C and group G streptococci and acute rheumatic fever in an Aboriginal population. (11030302)
2000
35
Prophylactic efficiency of 3-weekly benzathine penicillin G in rheumatic fever. (10838716)
2000
36
The psychiatric symptoms of rheumatic fever. (11097972)
2000
37
Urticarial eruption associated with rheumatic fever in a child. (10469414)
1999
38
T. Duckett Jones and his criteria for the diagnosis of acute rheumatic fever. (9926367)
1999
39
Rheumatic fever chemoprophylaxis in adults. (12152837)
1998
40
PANDAS: the search for environmental triggers of pediatric neuropsychiatric disorders. Lessons from rheumatic fever. (9733286)
1998
41
Advanced atrioventricular block in a 39-year-old man with acute rheumatic fever. (9826853)
1998
42
Search for linkage disequilibrium between alleles in the T cell receptor alpha and beta chain loci and susceptibility to rheumatic fever. (7493775)
1995
43
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
44
Release of oxygen free radicals by macrophages and neutrophils in patients with rheumatic fever. (1915447)
1991
45
Poststreptococcal diseases: pathogenetic aspects of rheumatic fever and acute poststreptococcal glomerulonephritis. (364376)
1978
46
Rheumatic fever as a collagen disease. (13339200)
1956
47
Rheumatic fever as a collagen disease. (13229241)
1954
48
Chronic relapsing febrile nodular nonsuppurative panniculitis (Weber-Christian disease); relation to rheumatic fever and allied diseases. (14780325)
1950
49
50

Variations for Rheumatic Fever

About this section

Expression for genes affiliated with Rheumatic Fever

About this section
Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

About this section

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 21)
idSuper pathwaysScoreTop Affiliating Genes
19.6CD40LG, IL2
29.4IL2, TNF
39.4IL2, TNF
4
Show member pathways
9.4IL2, TNF
59.3CD40LG, TLR2, TNF
69.3CD40LG, TLR2, TNF
79.2IL2, MBL2, TNF
8
Show member pathways
9.1IL2, TLR2, TNF
9
Show member pathways
9.1CD40LG, IL2, TNF
109.1HLA-DQA1, MBL2, TLR2
119.1HLA-DQA1, MASP2, MBL2
12
Show member pathways
9.0FCN2, FCN3, MASP2, MBL2
138.8HLA-DQA1, TLR2, TNF
148.8HLA-DQA1, TLR2, TNF
15
Show member pathways
8.8CD40LG, IL2, TLR2, TNF
16
Show member pathways
8.6FCN1, FCN2, FCN3, MASP2, MBL2
17
Show member pathways
8.5CD40LG, HLA-DQA1, TLR2, TNF
18
Show member pathways
8.5CD40LG, HLA-DQA1, TLR2, TNF
19
Show member pathways
8.3HLA-DQA1, IL2, TLR2, TNF
20
Show member pathways
8.0CD40LG, HLA-DQA1, IL2, TLR2, TNF
21
Show member pathways
6.1CD40LG, FCN1, FCN2, FCN3, HLA-DQA1, IL2

GO Terms for genes affiliated with Rheumatic Fever

About this section

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine productionGO:003272210.3TLR2, TNF
2negative regulation of growth of symbiont in hostGO:004413010.3MBL2, TNF
3regulation of immunoglobulin secretionGO:005102310.2CD40LG, TNF
4positive regulation of interferon-gamma productionGO:00327299.9IL2, TNF
5complement activation, lectin pathwayGO:00018679.7FCN2, FCN3, MASP2, MBL2
6defense response to Gram-positive bacteriumGO:00508309.5FCN2, MBL2, TLR2, TNF
7complement activationGO:00069569.4FCN1, FCN3, MASP2, MBL2
8immune responseGO:00069559.0IL2, TLR2, TNF
9proteolysisGO:00065088.0FCN1, FCN2, FCN3, HP, MBL2
10innate immune responseGO:00450877.8FCN1, FCN2, FCN3, IL2, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase activityGO:00042528.9FCN1, FCN2, FCN3, MASP2

Sources for Rheumatic Fever

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet