MCID: RHM001
MIFTS: 60

Rheumatic Fever malady

Cardiovascular, Bone categories

Summaries for Rheumatic Fever

Sources:
64Wikipedia, 47OMIM, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to arthritis and kawasaki disease, and has symptoms including erythema/erythematous lesions/erythroderma/polymorphous erythema, macules and subcutaneous nodules/lipomas/tumefaction/swelling. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Phagocytosis of Microbes and Immune response Lectin induced complement pathway. The drugs aspirin and choline salicylate and the compounds Palivizumab and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and skin.

Description from OMIM:47 268240

Aliases & Classifications for Rheumatic Fever

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 57SNOMED-CT, 40NCIt, 27ICD9CM, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular, Bone


Characteristics (Orphanet epidemiological data):

49
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


Aliases & Descriptions:

rheumatic fever 8 43 10 45 49 47 61
acute rheumatic fever 8 43 45 49
rheumatic fever without mention of heart involvement 8
rheumatic fever without heart involvement 8
acute rheumatic arthritis 8
acute rheumatic fever nos 8
rheumatic fever, active 8
inflammatory rheumatism 43
active rheumatic fever 8
rhf - rheumatic fever 8


External Ids:

Disease Ontology8 DOID:1586
NCIt40 C34984
ICD9CM27 390-392.99
MeSH35 D012213
ICD10 via Orphanet26 I01, I00
SNOMED-CT via Orphanet58 26424001, 58718002
UMLS via Orphanet62 C0035436
OMIM47 268240
MESH via Orphanet36 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 109)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0FCGR2A, FCGR3B, TLR2
2kawasaki disease30.7ADM, MBL2
3acute poststreptococcal glomerulonephritis30.6SKA2, SKA3, SKA1
4systemic lupus erythematosus30.4FCGR3B, FCGR2A
5nephritis30.0FCGR2A, FCGR3B
6rheumatic disease11.0
7q fever10.6
8chorea10.6
9reactive arthritis10.5
10scarlet fever10.5
11pharyngitis10.5
12subacute bacterial endocarditis10.4
13obsessive-compulsive disorder10.4
14sydenham's chorea10.4
15atrioventricular block10.3
16antiphospholipid syndrome10.3
17pulmonary edema10.3
18chronic rheumatic pericarditis10.2
19rheumatic myocarditis10.2
20septic arthritis10.2
21rheumatic congestive heart failure10.2
22n syndrome10.2
23aortic valve stenosis10.2
24chorea minor10.2
25syncope10.2
26coronary artery disease,10.2
27branch retinal artery occlusion10.0
28cardiac tamponade10.0
29decubitus ulcer10.0
30hemoglobin d disease10.0
31mitral valve prolapse10.0
32congenital heart block10.0
33hemoglobin c disease10.0
34iritis10.0
35familial mediterranean fever10.0
36nodular nonsuppurative panniculitis10.0
37mitral valve stenosis10.0
38diabetic ketoacidosis10.0
39osteonecrosis10.0
40subacute leukemia10.0
41erysipelas10.0
42henoch-schoenlein purpura10.0
43noonan syndrome10.0
44aseptic meningitis10.0
45rapidly progressive glomerulonephritis10.0
46tricuspid valve stenosis10.0
47kernicterus10.0
48dextrocardia10.0
49gastric ulcer10.0
50acute disseminated encephalomyelitis10.0

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Clinical Features for Rheumatic Fever

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

268240

Clinical synopsis from OMIM:

268240

Symptoms:

49 (show all 36)
  • erythema/erythematous lesions/erythroderma/polymorphous erythema
  • macules
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • pharyngitis
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • anorexia
  • arthritis/synovitis/synovial proliferation
  • fever/chilling
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • acute abdominal pain/colic
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • myocardium anomalies/myocarditis
  • endocardium anomalies/fibroelastosis/endocarditis
  • cardiac rhythm disorder/arrhythmia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • articular/joint pain/arthralgia
  • asthenia/fatigue/weakness
  • pallor
  • absent/hypotonic/flaccid abdominal wall muscles
  • constipation
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding

Drugs & Therapeutics for Rheumatic Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Rheumatic Fever

Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Search CenterWatch for Rheumatic Fever

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Rheumatic Fever:

33
Brain, Heart, Skin, Tonsil, Monocytes, T cells, B cells, Cardiac myocytes

Animal Models for Rheumatic Fever or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Rheumatic Fever

Sources:
51PubMed
See all sources

Articles related to Rheumatic Fever:

(show top 50)    (show all 552)
idTitleAuthorsYear
1
Susceptibility to acute rheumatic fever: differential expression of genes involved in cytotoxicity, chemotaxis and apoptosis. (24296338)
2013
2
Acute rheumatic fever with chorea. (23178398)
2013
3
Rheumatic fever & rheumatic heart disease: the last 50 years. (23703332)
2013
4
Use of Doppler echocardiography to support the decision to discontinue secondary prophylaxis for patients with rheumatic fever and normal cardiac auscultation. (23239309)
2013
5
Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever. (23659227)
2013
6
Adult-onset acute rheumatic fever. (23037480)
2012
7
Chorea in primary antiphospholipid syndrome is associated with rheumatic fever. (21881983)
2012
8
Role of cytokine gene (IFN-I^, TNF-I+, TGF-I^1, IL-6, and IL-10) polymorphisms in pathogenesis of acute rheumatic fever in Turkish children. (22350281)
2012
9
Rheumatic fever recurrence prevention: a nurse-led programme of 28-day penicillin in an area of high endemnicity. (21470327)
2011
10
Persistence of acute rheumatic fever in a tertiary children's hospital. (21199062)
2011
11
Mediterranean fever (MEFV) gene mutation frequency is not increased in adults with rheumatic heart disease. (20645115)
2011
12
Health-related quality of life of school- age children with rheumatic Fever. (21244818)
2010
13
I have a friend who was diagnosed with aortic valve stenosis, caused by calcium forming on the valve. I've heard that the condition can also be caused by rheumatic fever, which I had as a child almost 50 years ago. What exactly is aortic valve stenosis, and am I still at risk after all these years (I take medication for cholesterol and arthritis, but am otherwise pretty healthy)? (23043209)
2010
14
Perinatal risk factors and obsessive-compulsive spectrum disorders in patients with rheumatic fever. (19410109)
2009
15
Acute rheumatic fever in the Waikato District Health Board region of New Zealand: 1998-2004. (19079442)
2008
16
Consensus guidelines on pediatric acute rheumatic fever and rheumatic heart disease. (18695275)
2008
17
Erroneous diagnoses in children referred with acute rheumatic fever. (18174863)
2008
18
Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis, and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. (17446442)
2007
19
Jones criteria and underdiagnosis of rheumatic fever. (17337820)
2007
20
Evolution of valve damage in Sydenham's chorea during recurrence of rheumatic fever. (17049647)
2007
21
Obsessive-compulsive spectrum disorders and rheumatic fever: a family study. (16616727)
2007
22
B-cell antigen D8/17 is a marker of rheumatic fever susceptibility in Aboriginal Australians and can be tested in remote settings. (16719750)
2006
23
Changing epidemiology of acute rheumatic fever in the United States. (16421786)
2006
24
Hemichorea as a presentation of acute rheumatic fever. (17302227)
2006
25
Towards a vaccine against rheumatic fever. (17162355)
2006
26
Rheumatic fever--how relevant in India today? (16909716)
2006
27
Obsessive-compulsive symptoms in non-active rheumatic fever. (16810406)
2006
28
A new Toll-road from environment to genes for rheumatic fever? (15976915)
2005
29
Rheumatic fever reappraised. (15780203)
2005
30
Aseptic meningitis as initial presentation of rheumatic fever in an adult man: an extraordinary rare manifestation. (15854206)
2005
31
Role of serum cardiac troponin T in the diagnosis of acute rheumatic fever and rheumatic carditis. (15145883)
2004
32
Unusual rhythm problems in acute rheumatic fever: two patient reports. (15024446)
2004
33
Rheumatic fever in children under 5 years old. (15231963)
2004
34
Acute poststreptococcal glomerulonephritis and acute rheumatic fever in the same patient: a case report and review of the literature. (12967898)
2003
35
Evaluation of subclinical valvar disease in patients with rheumatic fever. (14982288)
2003
36
Acute rheumatic fever. (12240849)
2002
37
Declining trend of rheumatic fever observed in Bangladesh, 1991-1997. (11444344)
2001
38
Prophylactic efficiency of 3-weekly benzathine penicillin G in rheumatic fever. (10838716)
2000
39
Branch retinal artery occlusion: a case complicating acute rheumatic fever and dental abscess. (10953747)
2000
40
Association of HLA-DR7 with rheumatic fever in the Brazilian population. (10852281)
2000
41
Mortality due to acute rheumatic fever and rheumatic heart disease in the Northern Territory: a preventable cause of death in aboriginal people. (10330730)
1999
42
Hepatotoxicity of salicylate therapy in acute rheumatic fever. (10736599)
1999
43
Rheumatic fever and rheumatic heart disease: an overview. (10448231)
1999
44
The changing face of rheumatic fever in the 20th century. (9877185)
1998
45
Scleritis, uveitis, and glaucoma in a patient with rheumatic fever. (7573320)
1995
46
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: occurrence in the same patient. (2253249)
1990
47
Anti-streptopolysaccharide antibody in children with rheumatic fever and scarlet fever. (3327951)
1987
48
THE COEXISTENCE OF ACUTE RHEUMATIC FEVER AND SICKLE CELL-HEMOGLOBIN C DISEASE. (14247521)
1965
49
Coexistent rheumatic fever and subacute bacterial endocarditis treated with ACTH and antibiotics. (14902685)
1952
50
Reactions to intradermal administration of scarlet fever streptococcus toxin in rheumatic cardiac children. (21010702)
1945

Genetic Variations for Rheumatic Fever

Expression for genes affiliated with Rheumatic Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

Sources:
52QIAGEN, 12EMD Millipore, 54Reactome, 30KEGG
See all sources

Compounds for genes affiliated with Rheumatic Fever

Sources:
11DrugBank, 50PharmGKB, 45Novoseek, 24HMDB, 29IUPHAR
See all sources

Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1Palivizumab1110.6FCGR3B, FCGR2A
2Intravenous Immunoglobulin1110.6FCGR2A, FCGR3B
3Ibritumomab1110.6FCGR3B, FCGR2A
4bevacizumab50 1111.6FCGR3B, FCGR2A
5tositumomab50 1111.5FCGR3B, FCGR2A
6n-acetylglucosamine4510.5FCN1, FCN2, MBL2
7alefacept45 1111.5FCGR3B, FCGR2A
8efalizumab45 1111.5FCGR2A, FCGR3B
9nadph45 2411.5TLR2, PGD, FCGR2A, ADM
10mannan4510.5FCN2, FCN3, MASP2, MBL2, TLR2
11Muromonab1110.4FCGR2A, FCGR3B
12daclizumab45 1111.4FCGR3B, FCGR2A
13mannose4510.4TLR2, MBL2, MASP2, FCGR3B, FCGR2A
14serine4510.4FCGR2A, FCGR3B, MASP2, EGR3, TLR2
15superoxide45 2411.4ADM, FCGR3B, PGD, MBL2, TLR2
16basiliximab45 1111.4FCGR2A, FCGR3B
17polysaccharide4510.3TLR2, MBL2, FCN3, FCGR3B, FCGR2A, FCN2
18fibrinogen4510.3TLR2, MBL2, MASP2, MYOM2, FCN2, FCN1
19gemtuzumab ozogamicin45 1111.3FCGR3B, FCGR2A
20natalizumab45 1111.3FCGR2A, FCGR3B
21h2o24510.3ADM, FCGR2A, FCGR3B, PGD, TLR2
22prednisolone45 29 1112.1FCGR2A, FCGR3B, MBL2
23alemtuzumab45 1111.0FCGR2A, FCGR3B

GO Terms for genes affiliated with Rheumatic Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:00094010.1SKA1, SKA3, SKA2
2collagenGO:00558110.0MBL2, FCN3, FCN2, FCN1
3extracellular regionGO:0055769.9MBL2, FCN3, FCGR3B, FCN2, FCN1, ADM
4spindle microtubuleGO:0058769.8SKA3, SKA1, SKA2

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MBL2, TLR2
2opsonizationGO:00822810.3MBL2, FCN2, FCN1
3complement activation, lectin pathwayGO:00186710.2FCN1, FCN2, FCN3, MASP2, MBL2
4complement activationGO:00695610.2MBL2, MASP2, FCN3, FCN2, FCN1
5regulation of microtubule polymerization or depolymerizationGO:03111010.1SKA2, SKA1, SKA3
6chromosome segregationGO:0070599.8SKA2, SKA1, SKA3
7innate immune responseGO:0450879.8FCN1, FCGR2A, FCN3, TLR2, MASP2, MBL2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.3FCGR3B, FCGR2A
2calcium-dependent protein bindingGO:04830610.1MBL2, MASP2, FCN2
3protein bindingGO:0055158.9TLR2, MBL2, AKAP17A, MASP2, MYOM2, SKA2

Products for genes affiliated with Rheumatic Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet