MCID: RHM001
MIFTS: 65

Rheumatic Fever malady

Cardiovascular diseases, Bone diseases categories

Summaries for Rheumatic Fever

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Sources:
63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Rheumatic fever is an inflammatory disease that occurs following a Streptococcus pyogenes infection,... more...

MalaCards: Rheumatic Fever, also known as acute rheumatic fever, is related to arthritis and glomerulonephritis, and has symptoms including cardiac valvulopathy, pericardium anomalies/pericarditis/absence/cysts/pericardial effusion and nephrotic syndrome. An important gene associated with Rheumatic Fever is MBL2 (mannose-binding lectin (protein C) 2, soluble), and among its related pathways are Phagocytosis of Microbes and Immune response Lectin induced complement pathway. The drugs aspirin and choline salicylate and the compounds Palivizumab and Intravenous Immunoglobulin have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and skin.

Description from OMIM:46 268240

Aliases & Classifications for Rheumatic Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 56SNOMED-CT, 39NCIt, 27ICD9CM, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases, Bone diseases


Characteristics (Orphanet epidemiological data):

48
rheumatic fever:
Inheritance: Sporadic; Age of onset: Childhood; Age of death: Adult


Aliases & Descriptions:

rheumatic fever 8 42 10 44 48 46 60
acute rheumatic fever 8 42 44 48
rheumatic fever without mention of heart involvement 8
rheumatic fever without heart involvement 8
acute rheumatic arthritis 8
acute rheumatic fever nos 8
rheumatic fever, active 8
inflammatory rheumatism 42
active rheumatic fever 8
rhf - rheumatic fever 8


External Ids:

Disease Ontology8 DOID:1586
NCIt39 C34984
ICD9CM27 390-392.99
MeSH34 D012213
SNOMED-CT via Orphanet57 58718002
ICD10 via Orphanet26 I01.0, I00, I01.1 I01.2, I01.8, I01.9, more
UMLS via Orphanet61 C0035436
OMIM46 268240
MESH via Orphanet35 D012213
ICD1025 I00-I02

Related Diseases for Rheumatic Fever

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 122)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.0TLR2, FCGR3B, FCGR2A
2glomerulonephritis30.7MBL2, FCGR2A
3kawasaki disease30.7ADM, MBL2
4acute poststreptococcal glomerulonephritis30.6SKA3, SKA2, SKA1
5systemic lupus erythematosus30.3FCGR3B, FCGR2A
6rheumatoid arthritis30.2TLR2, MBL2, FCGR3B, FCGR2A
7leukemia30.0FCGR3B, MBL2, TLR2
8endocarditis10.6
9reactive arthritis10.5
10scarlet fever10.5
11pharyngitis10.5
12rheumatic myocarditis10.5
13subacute bacterial endocarditis10.4
14obsessive-compulsive disorder10.3
15chorea minor10.3
16atrioventricular block10.3
17antiphospholipid syndrome10.3
18pulmonary edema10.3
19infective endocarditis10.3
20collagen disease10.2
21lupus erythematosus10.2
22pericarditis10.2
23purpura10.2
24sydenham's chorea10.2
25chronic rheumatic pericarditis10.2
26septic arthritis10.2
27rheumatic congestive heart failure10.2
28acute orbital inflammation10.2
29aortic valve stenosis10.2
30pyoderma10.2
31coronary artery disease10.1
32connective tissue disease10.1
33branch retinal artery occlusion10.0
34cardiac tamponade10.0
35decubitus ulcer10.0
36mitral valve prolapse10.0
37congenital heart block10.0
38hemoglobin c disease10.0
39iritis10.0
40familial mediterranean fever10.0
41nodular nonsuppurative panniculitis10.0
42mitral valve stenosis10.0
43diabetic ketoacidosis10.0
44osteonecrosis10.0
45subacute leukemia10.0
46erysipelas10.0
47henoch-schoenlein purpura10.0
48noonan syndrome10.0
49aseptic meningitis10.0
50rapidly progressive glomerulonephritis10.0

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to rheumatic fever

Clinical Features for Rheumatic Fever

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Sources:
46OMIM, 48Orphanet
See all sources

Clinical features from OMIM:

268240

Clinical synopsis from OMIM:

268240

Symptoms:

48 (show all 36)
  • cardiac valvulopathy
  • pericardium anomalies/pericarditis/absence/cysts/pericardial effusion
  • nephrotic syndrome
  • facial pain/cephalalgia/migraine
  • abnormal gait
  • myoclonus/fasciculations
  • hemiballism/unilateral movement disorders
  • speech troubles/aphasia/dysphasia/echolalia/mutism/logorrhea/dysprosodia
  • alexia/agraphia/writing/reading troubles
  • psychic/behavioural troubles
  • epistaxis/nose bleeding
  • anorexia
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • abnormal pleura/hydrothorax/pleuresia/pleural effusion/chylothorax
  • acute abdominal pain/colic
  • nasal congestion/sinusitis/rhinitis/rhinorrhea
  • biological inflammatory syndrome/increased erythrocyte sedimentation rate/crp
  • fever/chilling
  • arthritis/synovitis/synovial proliferation
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • pharyngitis
  • subcutaneous nodules/lipomas/tumefaction/swelling
  • macules
  • thoracic/chest pain
  • mitral valve prolapse/incompetence/insufficiency/regurgitation/ring anomaly
  • aortic valve anomaly/incompetence/insufficiency/regurgitation/bicuspid
  • constipation
  • absent/hypotonic/flaccid abdominal wall muscles
  • pallor
  • asthenia/fatigue/weakness
  • articular/joint pain/arthralgia
  • chorea/athetosis/choreoathetosis/choreic syndrome
  • cardiac rhythm disorder/arrhythmia
  • endocardium anomalies/fibroelastosis/endocarditis
  • myocardium anomalies/myocarditis
  • erythema/erythematous lesions/erythroderma/polymorphous erythema

Drugs & Therapeutics for Rheumatic Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Rheumatic Fever

Drug clinical trials:

Search ClinicalTrials for Rheumatic Fever

Search NIH Clinical Center for Rheumatic Fever

Search CenterWatch for Rheumatic Fever

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Rheumatic Fever

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Anatomical Context for Rheumatic Fever

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Sources:
32MalaCards
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MalaCards organs/tissues related to Rheumatic Fever:

32
Heart, Brain, Skin, Bone, Lung, B cells, T cells, Testes, Tonsil, Cardiac myocytes, Monocytes

Animal Models for Rheumatic Fever or affiliated genes

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Publications for Rheumatic Fever

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Sources:
50PubMed
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Articles related to Rheumatic Fever:

(show top 50)    (show all 551)
idTitleAuthorsYear
1
A cost-effective strategy for primary prevention of acute rheumatic fever and rheumatic heart disease in children with pharyngitis. (24300622)
2013
2
Revisiting the pathogenesis of rheumatic fever and carditis. (23319102)
2013
3
Once weekly azithromycin in secondary prevention of rheumatic fever. (22572418)
2012
4
Acute rheumatic fever and rheumatic heart disease--priorities in prevention, diagnosis and management. A report of the CSANZ Indigenous Cardiovascular Health Conference, Alice Springs 2011. (22726405)
2012
5
Immune responsiveness during disease progression from acute rheumatic fever to chronic rheumatic heart disease. (22796386)
2012
6
Incidence of acute rheumatic fever in New Zealand children and youth. (22494483)
2012
7
Rheumatic fever in a patient receiving infliximab therapy for Crohn disease. (21150656)
2011
8
Post-streptococcal reactive arthritis in children: a distinct entity from acute rheumatic fever. (22013970)
2011
9
Fulminant valvulitis from acute rheumatic fever: successful use of extracorporeal support. (20921914)
2011
10
Acute disseminated encephalomyelitis associated with acute rheumatic fever. (21310343)
2011
11
Myocardial involvement in the hemodynamic abnormalities associated with acute rheumatic fever. (21264181)
2010
12
No demonstrable effect of benzathine penicillin on recurrence of rheumatic Fever in pacific island population. (20411251)
2010
13
Rheumatic fever in a 2-year-old child. (17952489)
2008
14
Subclinical valvulitis in children with acute rheumatic Fever. (18157644)
2008
15
Mothers' knowledge about acute rheumatic fever. (19006950)
2008
16
Guidelines on acute rheumatic fever. (19029580)
2008
17
Rheumatic fever diagnosis, management, and secondary prevention: a New Zealand guideline. (18392063)
2008
18
Epidemiology of acute rheumatic fever in New Zealand 1996-2005. (19012628)
2008
19
Prevention and control of rheumatic fever and rheumatic heart disease: the Cuban experience (1986-1996-2002). (18568172)
2008
20
Homocysteine levels and total antioxidant capacity in children with acute rheumatic fever. (17964295)
2008
21
Incidence of acute rheumatic fever in the world: a systematic review of population-based studies. (18669552)
2008
22
Acute rheumatic fever: adherence to secondary prophylaxis and follow up of Indigenous patients in the Katherine region of the Northern Territory. (17617086)
2007
23
T cell response in rheumatic fever: crossreactivity between streptococcal M protein peptides and heart tissue proteins. (17305559)
2007
24
Lack of association between TNFalpha gene polymorphism at position -308 and risk of acute rheumatic fever in Turkish patients. (16467041)
2006
25
Rheumatic fever-mimicking carditis as a first presentation of chronic active Epstein-Barr virus infection. (16825143)
2006
26
Rheumatic fever and rheumatic heart disease in Samoa. (18181388)
2006
27
Antecedent streptococcal infection in acute rheumatic fever. (16912940)
2006
28
The history of bacteriologic concepts of rheumatic fever and rheumatoid arthritis. (16884972)
2006
29
TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children. (15968536)
2005
30
Pathogenesis of acute rheumatic fever and rheumatic heart disease: evasive after half a century of clinical, epidemiological, and laboratory investigation. (15604318)
2005
31
Molecular pathogenesis of rheumatic fever and rheumatic heart disease. (16336741)
2005
32
Beta-haemolytic streptococci in school children 5-15 years of age with an emphasis on rheumatic fever, in the tri-island state of Grenada. (15892385)
2005
33
Induced subcutaneous nodules in the diagnosis of acute rheumatic fever. (16521656)
2005
34
Is it possible to prevent rheumatic fever? (15751529)
2004
35
D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorder. (15013984)
2004
36
Rheumatic fever: from sore throat to autoimmune heart lesions. (15103230)
2004
37
Intramuscular penicillin is more effective than oral penicillin in secondary prevention of rheumatic fever--a systematic review. (12768947)
2003
38
Patient views on the management of rheumatic fever and rheumatic heart disease in the Kimberley: a qualitative study. (14678407)
2003
39
Clinical profile of acute rheumatic fever in Pakistan. (12691285)
2003
40
Has the prevalence of rheumatic fever/rheumatic heart disease really changed? A hospital-based study. (12921330)
2003
41
Cardiac involvement in inflammatory disease: systemic lupus erythematosus, rheumatic fever, and Kawasaki disease. (11224023)
2001
42
Acute rheumatic fever in Noonan syndrome. (10985006)
2000
43
Further observations and characterization of monoclonal antibodies reacting with B cell alloantigens associated with rheumatic fever and rheumatic heart disease. (10711868)
2000
44
Vaccine strategies to prevent rheumatic fever. (10374697)
1999
45
Rheumatic fever in children. (10638124)
1999
46
Advanced atrioventricular block in a 39-year-old man with acute rheumatic fever. (9826853)
1998
47
Aspirin in acute rheumatic fever. (10216563)
1998
48
Acute rheumatic fever: diagnosis and treatment. (9622813)
1998
49
Prevalence of rheumatic fever and rheumatic heart disease in school children of Kathmandu city. (9505020)
1997
50
Serological investigations into sequelae of scarlet fever with particular reference to rheumatic fever. (13737136)
1961

Genetic Variations for Rheumatic Fever

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Expression for genes affiliated with Rheumatic Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for genes affiliated with Rheumatic Fever

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Sources:
51QIAGEN, 12EMD Millipore, 53Reactome, 29KEGG
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Compounds for genes affiliated with Rheumatic Fever

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Sources:
11DrugBank, 49PharmGKB, 44Novoseek, 24HMDB, 28IUPHAR
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Compounds related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1Palivizumab1110.6FCGR3B, FCGR2A
2Intravenous Immunoglobulin1110.6FCGR2A, FCGR3B
3Ibritumomab1110.6FCGR3B, FCGR2A
4bevacizumab49 1111.6FCGR3B, FCGR2A
5tositumomab49 1111.5FCGR3B, FCGR2A
6n-acetylglucosamine4410.5FCN1, FCN2, MBL2
7alefacept44 1111.5FCGR3B, FCGR2A
8efalizumab44 1111.5FCGR2A, FCGR3B
9nadph44 2411.5TLR2, PGD, FCGR2A, ADM
10mannan4410.5FCN2, FCN3, MASP2, MBL2, TLR2
11Muromonab1110.4FCGR2A, FCGR3B
12daclizumab44 1111.4FCGR3B, FCGR2A
13mannose4410.4TLR2, MBL2, MASP2, FCGR3B, FCGR2A
14serine4410.4FCGR2A, FCGR3B, MASP2, EGR3, TLR2
15superoxide44 2411.4ADM, FCGR3B, PGD, MBL2, TLR2
16basiliximab44 1111.4FCGR2A, FCGR3B
17polysaccharide4410.3TLR2, MBL2, FCN3, FCGR3B, FCGR2A, FCN2
18fibrinogen4410.3TLR2, MBL2, MASP2, MYOM2, FCN2, FCN1
19gemtuzumab ozogamicin44 1111.3FCGR3B, FCGR2A
20natalizumab44 1111.3FCGR2A, FCGR3B
21h2o24410.3ADM, FCGR2A, FCGR3B, PGD, TLR2
22prednisolone44 28 1112.1FCGR2A, FCGR3B, MBL2
23alemtuzumab44 1111.0FCGR2A, FCGR3B

GO Terms for genes affiliated with Rheumatic Fever

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16Gene Ontology
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Cellular components related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1condensed chromosome outer kinetochoreGO:00094010.1SKA1, SKA3, SKA2
2collagenGO:00558110.0FCN1, FCN2, FCN3, MBL2
3extracellular regionGO:0055769.9ADM, FCN1, FCN2, FCGR3B, FCN3, MASP2
4spindle microtubuleGO:0058769.8SKA2, SKA3, SKA1

Biological processes related to Rheumatic Fever according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.3MBL2, TLR2
2opsonizationGO:00822810.3FCN1, FCN2, MBL2
3complement activation, lectin pathwayGO:00186710.2FCN1, FCN2, FCN3, MASP2, MBL2
4complement activationGO:00695610.2MBL2, MASP2, FCN3, FCN2, FCN1
5regulation of microtubule polymerization or depolymerizationGO:03111010.1SKA2, SKA3, SKA1
6chromosome segregationGO:0070599.8SKA1, SKA3, SKA2
7innate immune responseGO:0450879.8TLR2, MBL2, MASP2, FCN3, FCGR2A, FCN2

Molecular functions related to Rheumatic Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1IgG bindingGO:01986410.3FCGR2A, FCGR3B
2calcium-dependent protein bindingGO:04830610.1FCN2, MASP2, MBL2
3protein bindingGO:0055158.9TLR2, MBL2, AKAP17A, MASP2, MYOM2, SKA2

Products for genes affiliated with Rheumatic Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Rheumatic Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet