MCID: RHM001
MIFTS: 54

Rheumatic Fever malady

Categories: Rare diseases, Cardiovascular diseases

Aliases & Classifications for Rheumatic Fever

Aliases & Descriptions for Rheumatic Fever:

Name: Rheumatic Fever 12 50 52 42 14 69
Acute Rheumatic Fever 12 50 52
Inflammatory Rheumatism 50
Rhf - Rheumatic Fever 12

Classifications:



Summaries for Rheumatic Fever

NIH Rare Diseases : 50 rheumatic fever is an inflammatory condition that may develop after infection with group a streptococcus bacteria, such as strep throat or scarlet fever. it is primarily diagnosed in children between the ages of 6 and 16 and can affect the heart, joints, nervous system and/or skin. early signs and symptoms include sore throat; swollen red tonsils; fever; headache; and/or muscle and joint aches. some affected people develop rheumatic heart disease, which can lead to serious inflammation and scarring of the heart valves. it is not clear why some people who are infected with group a streptococcus bacteria go on to develop rheumatic fever, while others do not; however, it appears that some families may have a genetic susceptibility to develop the condition. treatment usually includes antibiotics and/or anti-inflammatory medications. last updated: 1/11/2015

MalaCards based summary : Rheumatic Fever, also known as acute rheumatic fever, is related to choreatic disease and aseptic meningitis, and has symptoms including arthralgia, constipation and fatigue. An important gene associated with Rheumatic Fever is MYOM2 (Myomesin 2), and among its related pathways/superpathways are Innate Immune System and Allograft rejection. The drugs Liver Extracts and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and brain, and related phenotype is immune system.

Wikipedia : 71 Rheumatic fever (RF) is an inflammatory disease that can involve the heart, joints, skin, and brain. The... more...

Related Diseases for Rheumatic Fever

Diseases related to Rheumatic Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)
id Related Disease Score Top Affiliating Genes
1 choreatic disease 31.1 CD40LG HLA-DRB1 HP TNF
2 aseptic meningitis 29.6 HLA-DRB1 TLR2 TNF
3 dextrocardia 29.6 CD40LG MYOM2 TNF
4 tuberculosis 29.5 CD40LG IL2 TNF
5 rheumatoid arthritis 29.3 CD40LG HLA-DRB1 IL2 TLR2 TNF
6 rheumatic fever-related antigen rheumatic fever, acute, susceptibility to, included 12.3
7 sydenham chorea 11.6
8 rheumatic myocarditis 11.5
9 acute articular rheumatism 11.2
10 rheumatic encephalitis 11.0
11 aortic valve disease 2 10.9
12 heart disease 10.6
13 rheumatic heart disease 10.6
14 rheumatic disease 10.3
15 bilateral parasagittal parieto-occipital polymicrogyria 10.3 HLA-DRB1 TNF
16 mirizzi syndrome 10.3 HLA-DRB1 TNF
17 steatitis 10.3 IL2 TNF
18 autosomal dominant intermediate charcot-marie-tooth 10.3 HLA-DRB1 TNF
19 distal trisomy 14q 10.3 HLA-DRB1 TNF
20 arthritis 10.3
21 autosomal dominant deafness-onychodystrophy syndrome 10.3 IL2 TNF
22 meesmann corneal dystrophy 10.3 MASP2 MBL2
23 caplan's syndrome 10.3 HLA-DRB1 IL2
24 deafness, autosomal dominant 44 10.3 MASP2 MBL2
25 swine influenza 10.3 HLA-DRB1 TNF
26 tracheal calcification 10.3 MBL2 TNF
27 renal agenesis meningomyelocele mullerian defect 10.2 HLA-DRB1 IL2
28 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.2 IL2 TNF
29 warthin tumor 10.2 MBL2 TNF
30 jaw cancer 10.2 CD40LG MYOM2
31 acute allergic sanguinous otitis media 10.2 IL2 MYOM2
32 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 10.2 HLA-DRB1 TNF
33 pseudoainhum 10.2 MBL2 TLR2
34 indomethacin antenatal infection 10.2 CD40LG MBL2
35 submandibular gland disease 10.2 CD40LG TNF
36 cannabis dependence 10.2 CD40LG MYOM2
37 nerve compression syndrome 10.2 CD40LG MYOM2
38 clostridium difficile colitis 10.2 HLA-DRB1 IL2 TNF
39 thymic neuroendocrine carcinoma 10.2 IL2 MYOM2 TNF
40 hepatitis 10.2 HLA-DRB1 IL2 TNF
41 nystagmus, congenital motor, autosomal recessive 10.2 HLA-DRB1 TLR2 TNF
42 generalized atherosclerosis 10.2 CD40LG MYOM2
43 dermatitis herpetiformis 10.2 CD40LG TNF
44 endocarditis 10.2
45 human immunodeficiency virus infectious disease 10.2 CD40LG HLA-DRB1 TNF
46 blue toe syndrome 10.2 IL2 MYOM2 TNF
47 pancreatic signet ring cell adenocarcinoma 10.2 CD40LG HLA-DRB1 TNF
48 cryptococcosis 10.2 CD40LG HLA-DRB1 TNF
49 hereditary alpha tryptasemia syndrome 10.2 CD40LG HLA-DRB1 TNF
50 benign deep fibrous histiocytoma 10.2 CD40LG HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Rheumatic Fever:



Diseases related to Rheumatic Fever

Symptoms & Phenotypes for Rheumatic Fever

Human phenotypes related to Rheumatic Fever:

32 (show all 34)
id Description HPO Frequency HPO Source Accession
1 arthralgia 32 HP:0002829
2 constipation 32 HP:0002019
3 fatigue 32 HP:0012378
4 fever 32 HP:0001945
5 chest pain 32 HP:0100749
6 abdominal pain 32 HP:0002027
7 nausea and vomiting 32 HP:0002017
8 recurrent pharyngitis 32 HP:0100776
9 macule 32 HP:0012733
10 gait disturbance 32 HP:0001288
11 chorea 32 HP:0002072
12 respiratory insufficiency 32 HP:0002093
13 behavioral abnormality 32 HP:0000708
14 arthritis 32 HP:0001369
15 subcutaneous nodule 32 HP:0001482
16 arrhythmia 32 HP:0011675
17 pallor 32 HP:0000980
18 aplasia/hypoplasia of the abdominal wall musculature 32 HP:0010318
19 sinusitis 32 HP:0000246
20 abnormality of the aortic valve 32 HP:0001646
21 abnormality of the pleura 32 HP:0002103
22 nephrotic syndrome 32 HP:0000100
23 anorexia 32 HP:0002039
24 migraine 32 HP:0002076
25 erythema 32 HP:0010783
26 epistaxis 32 HP:0000421
27 abnormality of the mitral valve 32 HP:0001633
28 pericarditis 32 HP:0001701
29 fasciculations 32 HP:0002380
30 dyslexia 32 HP:0010522
31 dysgraphia 32 HP:0010526
32 myocarditis 32 HP:0012819
33 hemiballismus 32 HP:0100248
34 endocarditis 32 HP:0100584

MGI Mouse Phenotypes related to Rheumatic Fever:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CD40LG FCN1 HP IL2 MASP2 MBL2

Drugs & Therapeutics for Rheumatic Fever

Drugs for Rheumatic Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 114)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Liver Extracts Phase 4
2
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
3
Infliximab Approved Phase 3 170277-31-3
4
Etanercept Approved, Investigational Phase 3 185243-69-0
5
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
6
Rivaroxaban Approved Phase 3 366789-02-8
7
Warfarin Approved Phase 3 81-81-2 6691 54678486
8
Tofacitinib Approved, Investigational Phase 3 477600-75-2
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 3 58-05-9 54575, 6560146 143
11
Menadione Approved, Nutraceutical Phase 3 58-27-5 4055
12
Phytonadione Approved, Nutraceutical Phase 3 84-80-0 4812 5284607
13 Antimetabolites Phase 3
14 Antimetabolites, Antineoplastic Phase 3
15 Antirheumatic Agents Phase 3,Phase 2,Early Phase 1
16 Dermatologic Agents Phase 3
17 Folic Acid Antagonists Phase 3
18 Immunosuppressive Agents Phase 3
19 Nucleic Acid Synthesis Inhibitors Phase 3
20 Vitamin B Complex Phase 3
21 Gastrointestinal Agents Phase 3,Phase 2
22 Antibodies Phase 3,Phase 2,Phase 1
23 Antibodies, Monoclonal Phase 3,Phase 2,Phase 1
24 Immunoglobulins Phase 3,Phase 2,Phase 1
25 Analgesics Phase 3
26 Analgesics, Non-Narcotic Phase 3
27 Anti-Inflammatory Agents Phase 3,Phase 2
28 Anti-Inflammatory Agents, Non-Steroidal Phase 3
29 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
30 Natriuretic Peptide, Brain Phase 2, Phase 3
31 Interleukin 1 Receptor Antagonist Protein Phase 2, Phase 3
32 Pharmaceutical Solutions Phase 3,Phase 2,Phase 1
33 HIV Protease Inhibitors Phase 3,Phase 2
34
protease inhibitors Phase 3,Phase 2
35 Anticoagulants Phase 3
36 Antifibrinolytic Agents Phase 3
37 Antipyretics Phase 3
38 Antithrombin III Phase 3
39 Antithrombins Phase 3
40 Coagulants Phase 3
41 Cyclooxygenase Inhibitors Phase 3
42 Factor Xa Inhibitors Phase 3
43 Fibrinolytic Agents Phase 3
44 Hemostatics Phase 3
45 Micronutrients Phase 3
46 Platelet Aggregation Inhibitors Phase 3
47 Serine Proteinase Inhibitors Phase 3
48 Trace Elements Phase 3
49 Vitamins Phase 3
50 Protein Kinase Inhibitors Phase 3

Interventional clinical trials:

(show top 50) (show all 73)
id Name Status NCT ID Phase
1 A Study of Decreased Dose Frequency in Participants With Systemic Juvenile Arthritis Who Experience Laboratory Abnormalities During Treatment With RoActemra/Actemra (Tocilizumab) Recruiting NCT01734382 Phase 4
2 Erosive Osteoarthritis of the Hands: Treatment by Methotrexate Versus Placebo Unknown status NCT01068405 Phase 3
3 Infliximab Therapy in Patients With Refractory Polymyalgia Rheumatica Unknown status NCT01423591 Phase 3
4 Does Etanercept Influence Tweak Modulation of Inflammation During Inflammatory Rheumatisms (Psoriatic Arthritis and Rheumatoid Arthritis)? Completed NCT02164214 Phase 3
5 Mobile Health in Structural Heart Disease Completed NCT02881398 Phase 2, Phase 3
6 An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations Manifestations and Response Characterization Study in Canakinumab Treatment-naïve Patients With Active SJIA With and Wi Completed NCT00891046 Phase 3
7 A Study of RoActemra/Actemra (Tocilizumab) in Patients With Active Systemic Juvenile Idiopathic Arthritis (JIA) Completed NCT00642460 Phase 3
8 Study of the Safety and Efficacy of NC-503 in Secondary (AA) Amyloidosis Completed NCT00035334 Phase 2, Phase 3
9 Interleukin-1 Receptor Antagonist (IL-1RA) (ANAKINRA) IN SEVERE SYSTEMIC-ONSET JUVENILE IDIOPATHIC ARTHRITIS Completed NCT00339157 Phase 2, Phase 3
10 A Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis or Hereditary Periodic Fevers Who Participated in the CACZ885G2301E1, CACZ885G2306 or CACZ885N2301 Studies Recruiting NCT02334748 Phase 3
11 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Superiority Not yet recruiting NCT02832531 Phase 3
12 INVestIgation of rheumatiC AF Treatment Using Vitamin K Antagonists, Rivaroxaban or Aspirin Studies, Non-Inferiority Not yet recruiting NCT02832544 Phase 3
13 A Safety, Efficacy And Pharmacokinetics Study Of Tofacitinib In Pediatric Patients With sJIA Not yet recruiting NCT03000439 Phase 3
14 Safety and Efficacy Study of Etanercept (Enbrel®) In Children With Systemic Onset Juvenile Rheumatoid Arthritis Terminated NCT00078806 Phase 3
15 Efficacy of Physiotherapy on the Health and Quality of Life of the Rheumatic Patient Unknown status NCT02020668 Phase 2
16 Efficacy and Safety of Tocilizumab in Adult's Still Disease Unknown status NCT01002781 Phase 2
17 Preventive Measures for Childhood-Onset Obsessive-Compulsive Disorder and Tic Disorders (PANDAS Subgroup) Completed NCT00001359 Phase 2
18 N-acetylcysteine for Renal Protection in Patients With Rheumatic Heart Disease Undergoing Valve Replacement Completed NCT01704482 Phase 2
19 Validity Study of Glutamine to Improve Cardiac Function in Cardiac Surgery Completed NCT01794884 Phase 2
20 Mild Water-Filtered Near Infrared Whole-Body-Hyperthermia as an Adjunct in the Treatment of Fibromyalgia Completed NCT00324441 Phase 2
21 Safety and Effectiveness of Rilonacept for Treating Systemic Juvenile Idiopathic Arthritis in Children and Young Adults Completed NCT00534495 Phase 2
22 Interleukin-1 Trap to Treat Autoinflammatory Diseases Completed NCT00094900 Phase 2
23 Therapeutic Use of Tadekinig Alfa in Adult-onset Still's Disease Completed NCT02398435 Phase 2
24 Safety, Efficacy and Pharmacokinetics of Subcutaneous ACZ885 in Patients With Systemic Juvenile Idiopathic Arthritis (SJIA) Completed NCT00426218 Phase 1, Phase 2
25 TIV and High Dose TIV in Subjects With Rheumatoid Arthritis Completed NCT01436370 Phase 2
26 Clinical Trial of Gut Microbiota in the Management of Immune Thrombocytopenia Recruiting NCT03033199 Phase 2
27 A Repeated Dose-finding Study of Sarilumab in Children and Adolescents With Systemic Juvenile Idiopathic Arthritis (sJIA) Recruiting NCT02991469 Phase 2
28 Phase I Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetics of YHB1411-2 in Healthy Male Volunteers Completed NCT01525147 Phase 1
29 Dental Anesthesia in Pregnant Women With Rheumatic Heart Disease Completed NCT00482573 Phase 1
30 Efficacy of BLIS K12 as Preventive Measure for Rheumatic Children Unknown status NCT02407106
31 Development of Intervention Model for Osteoporosis and Fall Prevention in Taiwan Unknown status NCT01206491
32 Yellow Fever Vaccination Under Low Dose Methotrexate Therapy Unknown status NCT02383680
33 The Prevalence of Rheumatic Heart Disease in School Children in Fiji Unknown status NCT00779662
34 Rheumatic Heart Disease Prevalence in Leon, Nicaragua Unknown status NCT00307112
35 41.8 Degree Centigrade Whole Body Hyperthermia for the Treatment of Rheumatoid Diseases Unknown status NCT00000106
36 A Two-step Method Apparently Improved the Physicians' Level of Diagnosis Decision-making for Adult Patients With FUO Unknown status NCT02035670
37 Plasma Adiponectin Levels and Relations With Cytokines in Children With Acute Rheumatic Fever Completed NCT01886846
38 Hospital Based Incidence of Group A Streptococcal Disease in Fiji Completed NCT00264771
39 Evaluation of a Regional Healthy Skin Program in Remote Aboriginal Communities of Australia's Northern Territory Completed NCT00884728
40 Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren Completed NCT02353663
41 Impact of a Telenursing Service on Satisfaction and Health Outcomes of Children With Inflammatory Rheumatic Diseases Completed NCT01511341
42 Surveillance of Streptococcal Infections in Children in India Completed NCT00342199
43 Etude 3000 ARTHROSES Symptomatic Knee and Hip Osteoarthritis Prevalence Survey Completed NCT01400529
44 Study of the Influence of the Expression of the Calcium-sensitive Receptor (CaSR) by Monocytes in the Synovial Liquid on Structural Alterations in Patients Diagnosed With Rheumatoid Arthritis in the Previous Two Years Completed NCT02894047
45 C.O.R.P.U.S.: Observational Cohort of Adult and Child Inflammatory Arthritis in France Completed NCT02886689
46 Genetic Susceptibility to Rheumatic Heart Disease in the Pacific Region Completed NCT02188862
47 Effect of Simvastatin on Cardiac Function Completed NCT01178710
48 Effect of Rheumatic Heart Disease on Maternal and Fetal Outcomes Completed NCT03029117
49 Rheumatic Heart Disease Study in Lusaka Completed NCT02661763
50 DNA Typing of HLA-DR/DQ Alleles in Taiwan Chinese With Rheumatic Heart Disease Completed NCT00264524

Search NIH Clinical Center for Rheumatic Fever

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: rheumatic fever

Genetic Tests for Rheumatic Fever

Anatomical Context for Rheumatic Fever

MalaCards organs/tissues related to Rheumatic Fever:

39
Heart, Skin, Brain, Tonsil, T Cells, B Cells, Testes

Publications for Rheumatic Fever

Articles related to Rheumatic Fever:

(show top 50) (show all 649)
id Title Authors Year
1
Acute rheumatic fever and exposure to poor housing conditions in New Zealand: A descriptive study. ( 28052445 )
2017
2
Acute rheumatic fever outbreak in southern central European country. ( 27815733 )
2017
3
A retrospective study: Acute rheumatic fever and post-streptococcal reactive arthritis in Japan. ( 28442182 )
2017
4
Sharing success - understanding barriers and enablers to secondary prophylaxis delivery for rheumatic fever and rheumatic heart disease. ( 27581750 )
2016
5
Estimating the risk of acute rheumatic fever in New Zealand by age, ethnicity and deprivation. ( 27311633 )
2016
6
Nurse-led school-based clinics for rheumatic fever prevention and skin infection management: evaluation of Mana Kidz programme in Counties Manukau. ( 27348871 )
2016
7
Tracking isolated myocarditis in a young adult with acute rheumatic fever on cardiac magnetic resonance imaging. ( 27526359 )
2016
8
Rheumatic Fever: a neglected and underdiagnosed disease. New perspective on diagnosis and prevention. ( 27982273 )
2016
9
Rheumatic fever and rheumatic heart disease in Bangladesh: A review. ( 26896274 )
2016
10
Acute Rheumatic Fever: Global Persistence of a Preventable Disease. ( 27776916 )
2016
11
Acute Rheumatic Fever with Erythema Marginatum. ( 28002702 )
2016
12
2016 National Rheumatic Fever Week: The status of rheumatic heart disease in South Africa. ( 27499394 )
2016
13
Sugar, dental caries and the incidence of acute rheumatic fever: a cohort study of MA8ori and Pacific children. ( 27836917 )
2016
14
Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever. ( 27774884 )
2016
15
CHANGING CLINICAL PROFILE OF ACUTE RHEUMATIC FEVER AND RHEUMATIC RECURRENCE. ( 27323580 )
2016
16
Difficulties in the differential diagnosis between Takayasu arteritis and rheumatic fever: case report. ( 27267341 )
2016
17
Rheumatic Fever and Rheumatic Heart Disease a Historical Perspective. ( 27867464 )
2016
18
A Cost-Effectiveness Tool to Guide the Prioritization of Interventions for Rheumatic Fever and Rheumatic Heart Disease Control in African Nations. ( 27512994 )
2016
19
Post-Streptococcal Autoimmune Sequelae: Rheumatic Fever and Beyond ( 26866235 )
2016
20
A Review of Acute Rheumatic Fever and Rheumatic Heart Disease Research in Malaysia. ( 27801390 )
2016
21
Update on diagnosis of acute rheumatic fever: 2015 Jones criteria. ( 27103858 )
2016
22
Junctional tachycardia in a child with non-rheumatic fever streptococcal pharyngitis. ( 27989256 )
2016
23
Acute rheumatic fever and rheumatic heart disease. ( 27228242 )
2016
24
Advanced heart block in acute rheumatic fever. ( 27053901 )
2016
25
Acute rheumatic fever and rheumatic heart disease. ( 27188830 )
2016
26
Acute Rheumatic Fever: An Evidence-Based Approach To Diagnosis And Initial Management. ( 27462838 )
2016
27
Administering intramuscular penicillin injections to reduce rheumatic fever. ( 27281906 )
2016
28
Acute poststreptococcal glomerulonephritis and acute rheumatic fever: An uncommon coincidence. ( 27625530 )
2016
29
Cardiac Myosin Epitopes Recognized by Autoantibody in Acute and Convalescent Rheumatic Fever. ( 27273689 )
2016
30
Mitral valve enhancement in a patient with active Rheumatic Fever: An uncommon phenomenon on the MRI examination with possible clinical significance. ( 27878698 )
2016
31
An epidemiological study to assess the true incidence and prevalence of rheumatic heart disease and acute rheumatic fever in New Caledonian schoolchildren. ( 27203400 )
2016
32
Primary Prevention of Rheumatic Fever. ( 27351359 )
2016
33
Arterial stiffness during acute and recovery phases of children with rheumatic fever. ( 27130739 )
2016
34
Association between rheumatic fever and Takayasu's arteritis - Case report. ( 27267532 )
2016
35
Serological Evidence of Immune Priming by Group A Streptococci in Patients with Acute Rheumatic Fever. ( 27499748 )
2016
36
Long-Term Outcomes From Acute Rheumatic Fever and Rheumatic Heart Disease: A Data-Linkage and Survival Analysis Approach. ( 27407071 )
2016
37
WHAT IS ACUTE RHEUMATIC FEVER (ARF) AND RHEUMATIC HEART DISEASE (RHD)? ( 27132395 )
2016
38
Significance of silent carditis and investigation of follow-up signs in acute rheumatic fever. ( 27097234 )
2016
39
Interleukin-10: Role in increasing susceptibility and pathogenesis of rheumatic fever/rheumatic heart disease. ( 27918954 )
2016
40
Atypical arthritis revisited: Acute rheumatic fever. ( 27212853 )
2016
41
Preliminary consultation on preferred product characteristics of benzathine penicillin G for secondary prophylaxis of rheumatic fever. ( 27465618 )
2016
42
No Evidence of Human Leukocyte Antigen Gene Association With Rheumatic Fever Among Children in Samoa. ( 26407361 )
2015
43
An important investment to control Acute Rheumatic Fever needs to run its course. ( 26117670 )
2015
44
A 39-year-old man with recurrent rheumatic fever. ( 25487659 )
2015
45
National Advisory Committee for the Prevention and Control of Rheumatic Fever and Rheumatic Heart Disease in Namibia. ( 26659439 )
2015
46
Acute suppurative oligoarthritis and osteomyelitis: a differential diagnosis that overlaps with acute rheumatic fever. ( 25960155 )
2015
47
Heart lesion after the first attack of the rheumatic Fever 22 years experience in single centre. ( 25870479 )
2015
48
A Case of Acute Rheumatic Fever With Henoch Schonlein Purpura. ( 26635933 )
2015
49
Rheumatic fever: a forgotten but still existing cause of fever of unknown origin detected on FDG PET/CT. ( 25546214 )
2015
50
Childhood nutrition and prevention of rheumatic fever. ( 25754573 )
2015

Variations for Rheumatic Fever

Expression for Rheumatic Fever

Search GEO for disease gene expression data for Rheumatic Fever.

Pathways for Rheumatic Fever

Pathways related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 CD40LG FCN1 FCN2 FCN3 HLA-DRB1 HP
2
Show member pathways
12.64 CD40LG HLA-DRB1 IL2 TNF
3
Show member pathways
12.57 HLA-DRB1 IL2 TLR2 TNF
4
Show member pathways
12.48 CD40LG IL2 TLR2 TNF
5
Show member pathways
12.41 CD40LG HLA-DRB1 IL2 TNF
6
Show member pathways
12.38 HLA-DRB1 IL2 TLR2 TNF
7 12.31 CD40LG IL2 TLR2 TNF
8 12.02 HLA-DRB1 TLR2 TNF
9 11.93 HLA-DRB1 MBL2 TLR2
10
Show member pathways
11.89 CD40LG HLA-DRB1 TLR2 TNF
11
Show member pathways
11.73 IL2 TLR2 TNF
12
Show member pathways
11.68 FCN2 FCN3 MASP2 MBL2
13 11.63 HLA-DRB1 TLR2 TNF
14
Show member pathways
11.53 CD40LG IL2 TNF
15 11.48 CD40LG TLR2 TNF
16
Show member pathways
11.41 CD40LG IL2 TNF
17 11.33 HLA-DRB1 MASP2 MBL2
18 11.23 CD40LG TLR2 TNF
19
Show member pathways
11.18 FCN1 FCN2 FCN3 MASP2 MBL2
20 11.03 HLA-DRB1 IL2
21 11.01 CD40LG IL2 TNF
22 10.81 HLA-DRB1 IL2 TNF

GO Terms for Rheumatic Fever

Cellular components related to Rheumatic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 CD40LG HP IL2 MASP2 MBL2 TNF
2 extracellular region GO:0005576 9.61 CD40LG FCN1 FCN2 FCN3 HP IL2
3 cell surface GO:0009986 9.55 CD40LG HLA-DRB1 MBL2 TLR2 TNF
4 collagen trimer GO:0005581 8.92 FCN1 FCN2 FCN3 MBL2

Biological processes related to Rheumatic Fever according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.88 FCN1 FCN2 FCN3 HP MASP2 MBL2
2 immune response GO:0006955 9.85 CD40LG HLA-DRB1 IL2 TLR2 TNF
3 innate immune response GO:0045087 9.85 FCN1 FCN2 FCN3 MASP2 MBL2 TLR2
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.7 CD40LG TLR2 TNF
5 defense response to Gram-positive bacterium GO:0050830 9.62 FCN2 MBL2 TLR2 TNF
6 positive regulation of phagocytosis GO:0050766 9.58 MBL2 TNF
7 positive regulation of interleukin-8 production GO:0032757 9.58 TLR2 TNF
8 positive regulation of interleukin-12 production GO:0032735 9.57 CD40LG TLR2
9 positive regulation of interleukin-10 production GO:0032733 9.56 CD40LG TLR2
10 immune system process GO:0002376 9.56 FCN1 FCN2 FCN3 HLA-DRB1 IL2 MASP2
11 positive regulation of NF-kappaB import into nucleus GO:0042346 9.55 TLR2 TNF
12 complement activation GO:0006956 9.55 FCN1 FCN2 FCN3 MASP2 MBL2
13 negative regulation of viral entry into host cell GO:0046597 9.54 FCN1 FCN3
14 positive regulation of chemokine production GO:0032722 9.51 TLR2 TNF
15 negative regulation of growth of symbiont in host GO:0044130 9.49 MBL2 TNF
16 opsonization GO:0008228 9.48 FCN2 MBL2
17 regulation of immunoglobulin secretion GO:0051023 9.43 CD40LG TNF
18 recognition of apoptotic cell GO:0043654 9.43 FCN1 FCN2 FCN3
19 complement activation, lectin pathway GO:0001867 9.02 FCN1 FCN2 FCN3 MASP2 MBL2

Molecular functions related to Rheumatic Fever according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.35 FCN1 FCN2 FCN3 IL2 MBL2
2 calcium-dependent protein binding GO:0048306 9.33 FCN2 MASP2 MBL2
3 signaling pattern recognition receptor activity GO:0008329 9.26 FCN1 TLR2
4 serine-type endopeptidase activity GO:0004252 9.1 FCN1 FCN2 FCN3 HP MASP2 MBL2

Sources for Rheumatic Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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